@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KPCG_HUMAN: (2020-09-12 )
MAGLGPGVGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTADEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPRNLTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELLKAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFDGEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPDGEPTIRAHGFFRWIDWERLERLEIPPPFRPRPCGRSGENFDKFFTRAAPALTPPDRLVLASIDQADFQGFTYVNPDFVHPDARSPTSPVPVPVM
Atome Classification :
(435 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.........300.......310.......320.......330.......340.......350.......360.......---370-.-..-.--.....380.......390........400-.......410.......420......-.430.......440.......-450---........460.......470..-.....480.......-490.......500.......510.--..-.-...520......---.530---.-----........540.......550....-----....560--.---.......--.-----570...---.---...580.......590.......-600-.-.-......610......---.620......-.630..-...-.-.640.--.......650.......660......-..---670.......680.......690.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAGLGPGVGDSEGGPRP
L
F
CRKG
A
L
R
Q
K
V
V
H
E
V
K
S
H
K
F
T
A
R
F
FKQP
T
F
C
S
H
C
T
D
F
I
W
G
I
GKQG
L
Q
C
Q
V
C
S
F
V
V
H
R
R
C
H
E
F
V
T
F
ECPGAGKGPQTDDPRN
K
H
K
F
R
L
HSYSSP
T
F
C
D
H
C
G
S
L
L
Y
G
L
V
HQGMKC
S
C
C
E
M
N
V
H
R
R
C
V
R
S
V
P
S
L
CGVDHTERR
G
R
L
Q
L
E
I
RAPTA
D
E
I
H
V
T
VGEARNLIPMDPNGLSDP
Y
V
K
L
K
LIPDPR
N
L
T
K
Q
KT
R
T
V
K
A
T
LNPVWNE
T
F
V
F
NLKPG
D
V
E
R
R
L
S
V
E
V
W
DWDRTSR
N
D
F
M
G
A
M
S
F
G
V
S
E
L
L
KAP
V
D
G
W
Y
K
L
LNQEEG
E
Y
YNVPV--ADAD
N
C
S
L
L
Q
K
F
E
ACNY
P
L
E
L
Y
E
R
VRMGPSSSPIPSPSPSPT
D
P
K
R
C
FFGASPG
R
L
H
ISD
F
S
F
L
M
V
LGKGSFG
K
V
M
L
A
E---R---R-GS-D--
E
L
Y
A
I
K
I
L
KK
D
V
I
V
QD-DDV
D
C
T
L
V
E
K
R
V
-
L
ALGGRGPGGR
P
H
F
L
T
Q
L
H
S
T
FQTP
D
-
R
L
Y
F
V
M
E
YVTG
G
D
L
M
Y
H
I
Q
Q
L
-GK----FKEP
H
A
A
F
Y
A
A
E
I
A
I
G
L
F
F
L
HNQ-
G
I
I
Y
R
D
L
K
L
D
N
V
M
LD-AEG
H
I
K
I
T
DFGMCKENVFPGTTTR--TF-C-GTPDYIAP
E
I
I
A
---YQ-----P-----YGKSV
D
W
W
S
F
G
V
L
L
Y
E
M
LAG-QPPF-----DGE
D
E
----
E
---
E
L
F
Q
A
I
M
--
E
-----
Q
TVTY
P
---
K
---
S
L
S
R
E
A
V
A
I
C
K
G
F
L
TKHPGKRLG-S-G-P-D-GE
P
T
I
R
AH
G
F
F
R
WI
D
---
W
E
R
L
E
RLEIP-PPFRPR-PCG-R-SG-E
N
--
F
D
K
F
F
T
RAAPALTPPD
R
L
-
V
L
A
SIDQ-AD---FQ
G
F
T
YVNPDFVHPDARSPTSPVPVPVM
551
HHSearch
96.22
71%
-102
- C2 -
-
3PFQ
1
KPCB_RAT
A:
[102-669]
---------------------------------------------------------------------------------------------------
K
H
K
F
K
I
H
T
Y
S
S
P
T
F
C
D
H
C
G
S
L
L
Y
G
L
I
H
Q
G
M
K
C
D
T
C
M
M
N
V
H
K
R
C
V
M
N
V
P
S
L
C
G
T
D
H
T
E
R
R
G
R
I
Y
I
Q
A
H
I
-
D
R
E
V
L
I
V
V
V
R
D
A
K
N
L
V
P
M
D
P
N
G
L
S
D
P
Y
V
K
L
K
L
I
P
D
P
K
S
E
S
K
Q
K
T
K
T
I
K
S
S
L
N
P
E
W
N
E
T
F
R
F
Q
L
K
E
S
D
K
D
R
R
L
S
V
E
I
W
D
W
D
L
T
S
R
N
D
F
M
G
S
L
S
F
G
I
S
E
L
Q
K
A
G
V
D
G
W
F
K
L
L
S
Q
E
E
G
E
Y
F
N
V
P
V
--
P
P
-------------------------------------------------------
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
---
R
---
K
-
G
T
-
D
--
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
A
L
P
G
-----
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
R
----
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
V
T
T
K
--
T
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
I
A
---
Y
Q
-----
P
-----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
-
Q
A
P
F
-----
E
G
E
D
E
----
D
---
E
L
F
Q
S
I
M
--
E
-----
H
N
V
A
Y
P
---
K
---
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
-
C
-
G
-
P
-
E
-
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
-
P
P
Y
K
P
K
-
A
S
G
-
R
-
N
A
-
E
N
--
F
D
R
F
F
T
R
H
P
P
V
L
T
P
P
D
Q
E
-
V
I
R
N
I
D
Q
-
S
E
---
F
E
G
F
S
F
V
N
S
E
F
L
K
---------------
1
PsiBlast_PDB
86.18
68%
-15
- C2 -
-
3PFQ
1
KPCB_RAT
A:
[102-670]
---------------------------------------------------------------------------------------------------
K
H
K
F
K
I
H
T
Y
S
S
P
T
F
C
D
H
C
G
S
L
L
Y
G
L
I
H
Q
G
M
K
C
D
T
C
M
M
N
V
H
K
R
C
V
M
N
V
P
S
L
C
G
T
D
H
T
E
R
R
G
R
I
Y
I
Q
A
H
I
-
D
R
E
V
L
I
V
V
V
R
D
A
K
N
L
V
P
M
D
P
N
G
L
S
D
P
Y
V
K
L
K
L
I
P
D
P
K
S
E
S
K
Q
K
T
K
T
I
K
S
S
L
N
P
E
W
N
E
T
F
R
F
Q
L
K
E
S
D
K
D
R
R
L
S
V
E
I
W
D
W
D
L
T
S
R
N
D
F
M
G
S
L
S
F
G
I
S
E
L
Q
K
A
G
V
D
G
W
F
K
L
L
S
Q
E
E
G
E
Y
F
N
V
P
V
PP---------------------------------------------------------
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
---
R
---
K
-
G
T
-
D
--
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
A
L
P
G
K
P
P
-----
F
L
T
Q
L
H
S
C
F
Q
T
M
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
R
----
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
V
T
T
K
--
T
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
I
A
---
Y
Q
-----
P
-----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
-
Q
A
P
F
-----
E
G
E
D
E
----
D
---
E
L
F
Q
S
I
M
--
E
-----
H
N
V
A
Y
P
---
K
---
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
-
C
-
G
-
P
-
E
-
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
-
P
P
Y
K
P
K
-
A
S
G
-
R
-
N
A
-
E
N
--
F
D
R
F
F
T
R
H
P
P
V
L
T
P
P
D
Q
E
-
V
I
R
N
I
D
Q
-
S
E
---
F
E
G
F
S
F
V
N
S
E
F
L
K
P
--------------
555
HHSearch
73.38
76%
-114
- C2 -
-
2I0E
-
KPCB_HUMAN
A:
[19-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
---
R
---
K
-
G
T
-
D
--
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
A
L
P
G
-----
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
R
----
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
V
T
T
K
--
T
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
I
A
---
Y
Q
-----
P
-----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
-
Q
A
P
F
-----
E
G
E
D
E
----
D
---
E
L
F
Q
S
I
M
--
E
-----
H
N
V
A
Y
P
---
K
---
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
-
C
-
G
-
P
-
E
-
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
-
P
P
Y
K
P
K
-
A
C
G
-
R
----
E
N
--
F
D
R
F
F
T
R
H
P
P
V
L
T
P
P
D
Q
E
-
V
I
R
N
I
D
Q
-
S
E
---
F
E
G
F
S
F
V
N
S
E
F
L
K
P
--------------
4
PsiBlast_PDB
72.53
74%
-113
- C2 -
-
2I0E
-
KPCB_HUMAN
A:
[19-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
---
R
---
K
-
G
T
-
D
--
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
A
L
P
G
K
P
P
-----
F
L
T
Q
L
H
S
C
F
Q
T
M
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
R
----
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
V
T
T
K
--
T
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
I
A
---
Y
Q
-----
P
-----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
-
Q
A
P
F
-----
E
G
E
D
E
----
D
---
E
L
F
Q
S
I
M
--
E
-----
H
N
V
A
Y
P
---
K
---
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
-
C
-
G
-
P
-
E
-
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
-
P
P
Y
K
P
K
-
A
C
G
-
R
----
E
N
--
F
D
R
F
F
T
R
H
P
P
V
L
T
P
P
D
Q
E
-
V
I
R
N
I
D
Q
-
S
E
---
F
E
G
F
S
F
V
N
S
E
F
L
K
P
--------------
558
HHSearch
72.28
77%
-118
- C2 -
-
4RA4
1
KPCA_HUMAN
A:
[15-349]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
K
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
A
D
---
R
---
K
-
G
T
-
E
--
E
L
Y
A
I
K
I
L
K
K
D
V
V
I
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
A
L
L
D
-----
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
K
----
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
H
M
M
D
G
V
T
T
R
--
T
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
I
A
---
Y
Q
-----
P
-----
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
-
Q
P
P
F
-----
D
G
E
D
E
----
D
---
E
L
F
Q
S
I
M
--
E
-----
H
N
V
S
Y
P
---
K
---
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
R
L
G
-
C
-
G
-
P
-
E
-
G
E
R
D
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
-
P
P
F
K
P
K
---------------------
G
Q
P
V
L
T
P
P
D
Q
L
-
V
I
A
N
I
D
Q
-
S
D
---
F
E
G
F
S
Y
V
N
P
Q
F
V
H
P
--------------
3
PsiBlast_PDB
71.39
75%
-118
- C2 -
-
4RA4
1
KPCA_HUMAN
A:
[16-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
K
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
A
D
---
R
---
K
-
G
T
-
E
--
E
L
Y
A
I
K
I
L
K
K
D
V
V
I
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
A
L
L
D
K
P
P
-----
F
L
T
Q
L
H
S
C
F
Q
T
V
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
K
----
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
H
M
M
D
G
V
T
T
R
--
T
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
I
A
---
Y
Q
-----
P
-----
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
-
Q
P
P
F
-----
D
G
E
D
E
----
D
---
E
L
F
Q
S
I
M
--
E
-----
H
N
V
S
Y
P
---
K
---
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
R
L
G
-
C
-
G
-
P
-
E
-
G
E
R
D
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
-
P
P
F
K
P
K
---------------------
G
Q
P
V
L
T
P
P
D
Q
L
-
V
I
A
N
I
D
Q
-
S
D
---
F
E
G
F
S
Y
V
N
P
Q
F
V
H
P
--------------
2
PsiBlast_PDB
71.03
75%
-111
- C2 -
-
3IW4
-
KPCA_HUMAN
A:
[15-351]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
K
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
A
D
---
R
---
K
-
G
T
-
E
--
E
L
Y
A
I
K
I
L
K
K
D
V
V
I
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
A
L
L
D
K
P
P
-----
F
L
T
Q
L
H
S
C
F
Q
T
V
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
K
----
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
H
M
M
D
G
V
T
T
R
--
E
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
I
A
---
Y
Q
-----
P
-----
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
-
Q
P
P
F
-----
D
G
E
D
E
----
D
---
E
L
F
Q
S
I
M
--
E
-----
H
N
V
S
Y
P
---
K
---
S
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
R
L
G
-
C
-
G
-
P
-
E
-
G
E
R
D
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
-
P
P
F
K
P
K
-
V
------------
F
D
K
F
F
T
R
G
Q
P
V
L
T
P
P
D
Q
L
-
V
I
A
N
I
D
Q
-
S
D
---
F
E
G
F
S
Y
V
N
P
Q
F
V
H
P
I
L
Q
-----------
554
HHSearch
69.73
75%
-121
- C2 -
-
2I0E
-
KPCB_HUMAN
B:
[19-349]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
D
F
N
F
L
M
V
L
G
K
G
S
F
G
K
V
M
L
S
E
---
R
---
K
-
G
T
-
D
--
E
L
Y
A
V
K
I
L
K
K
D
V
V
I
Q
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
A
L
P
G
-----
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
V
-
G
R
----
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
-
S
E
G
H
I
K
I
A
D
F
G
M
C
K
E
N
I
W
D
G
V
T
T
K
--
T
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
I
A
---
Y
Q
-----
P
-----
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
-
Q
A
P
F
-----
E
G
E
D
E
----
D
---
E
L
F
Q
S
I
M
--
E
-----
H
N
V
A
Y
P
---
K
---
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
R
L
G
-
C
-
G
-
P
-
E
-
G
E
R
D
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
-
P
P
Y
K
P
K
-
A
-----------------------------------
I
D
Q
-
S
E
---
F
E
G
F
S
F
V
N
S
E
F
L
K
P
--------------
556
HHSearch
66.97
56%
-100
- C2 -
-
4RA5
3
KPCT_HUMAN
A:
[2-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
-
K
T
-
N
--
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
-----
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
---
G
Q
-----
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
G
Q
D
E
----
E
---
E
L
F
H
S
I
R
--
M
-----
D
N
P
F
Y
P
---
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
-
V
-
R
-------
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
-
P
P
F
R
P
K
-
V
K
S
-
P
F
D
C
-
S
N
--
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
-
L
I
N
S
M
D
Q
-
N
M
---
F
R
N
F
S
F
M
N
P
G
M
E
----------------
10
PsiBlast_PDB
66.91
55%
-100
- C2 -
-
4RA5
3
KPCT_HUMAN
A:
[1-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
-
K
T
-
N
--
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
E
H
P
-----
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
---
G
Q
-----
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
G
Q
D
E
----
E
---
E
L
F
H
S
I
R
--
M
-----
D
N
P
F
Y
P
---
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
-
V
-
R
-
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
-
P
P
F
R
P
K
-
V
K
S
P
F
-
D
C
-
S
N
--
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
-
L
I
N
S
M
D
Q
-
N
M
---
F
R
N
F
S
F
M
N
P
-------------------
6
PsiBlast_PDB
66.52
55%
-94
- C2 -
-
5F9E
1
KPCT_HUMAN
A:
[15-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
-
K
T
-
N
--
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
E
H
P
-----
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
---
G
Q
-----
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
G
Q
D
E
----
E
---
E
L
F
H
S
I
R
--
M
-----
D
N
P
F
Y
P
---
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
-
V
-
R
-
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
-
P
P
F
R
P
K
V
K
S
P
-
F
-
D
C
-
S
N
--
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
-
L
I
N
S
M
D
Q
-
N
M
---
F
R
N
F
S
F
M
N
P
-------------------
24
Blastp_CBE
66.47
56%
-108
- C2 -
-
4RA5
1
B:
[2-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
-
K
T
-
N
--
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
E
H
P
-----
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
---
G
Q
-----
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
G
Q
D
E
----
E
---
E
L
F
H
S
I
R
--
M
-----
D
N
P
F
Y
P
---
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
-
V
-
R
-
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
-
P
P
F
R
P
K
-
V
K
S
P
F
-
D
---------------
P
R
L
---
D
R
A
-
L
I
N
S
M
D
Q
-
N
M
---
F
R
N
F
-
F
M
N
P
-------------------
9
PsiBlast_PDB
66.34
55%
-97
- C2 -
-
4Q9Z
1
KPCT_HUMAN
A:
[2-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
-
K
T
-
N
--
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
E
H
P
-----
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
---
G
Q
-----
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
G
Q
D
E
----
E
---
E
L
F
H
S
I
R
--
M
-----
D
N
P
F
Y
P
---
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
-
V
-
R
-
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
-
P
P
F
R
P
K
-
V
K
S
P
F
-
D
C
-
S
N
--
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
-
L
I
N
S
M
D
Q
-
N
M
---
F
R
N
F
S
F
M
N
P
-------------------
26
Blastp_CBE
66.05
56%
-121
- C2 -
-
5F9E
1
B:
[16-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
-
K
T
-
N
--
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
E
H
P
-----
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
---
G
Q
-----
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
G
Q
D
E
----
E
---
E
L
F
H
S
I
R
--
M
-----
D
N
P
F
Y
P
---
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
-
V
-
R
-
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
-
P
P
F
R
P
K
V
K
---------------------------------------
N
M
---
F
R
N
F
-
F
M
N
P
-------------------
25
Blastp_CBE
65.43
56%
-110
- C2 -
-
4Q9Z
1
B:
[1-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
-
K
T
-
N
--
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
E
H
P
-----
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
---
G
Q
-----
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
G
Q
D
E
----
E
---
E
L
F
H
S
I
R
--
M
-----
D
N
P
F
Y
P
---
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
-
V
-
R
-
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
-
P
P
F
R
P
K
-
V
K
S
P
F
-
D
C
-
S
N
--
F
D
K
------------------------
N
M
---
F
R
N
F
-
F
M
N
P
-------------------
8
PsiBlast_PDB
65.16
55%
-91
- C2 -
-
2JED
-
KPCT_HUMAN
A:
[15-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
I
E
D
F
E
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
-
K
T
-
N
--
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
E
H
P
-----
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
E
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
---
G
Q
-----
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
G
Q
D
E
----
E
---
E
L
F
H
S
I
R
--
M
-----
D
N
P
F
Y
P
---
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
-
V
-
R
-
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
-
P
P
F
R
P
K
V
K
S
P
-
F
-
D
C
-
S
N
--
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
-
L
I
N
S
M
D
Q
-
N
M
---
F
R
N
F
S
F
M
N
P
-------------------
7
PsiBlast_PDB
64.53
55%
-129
- C2 -
-
1XJD
1
A:
[16-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
-
K
T
-
N
--
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
E
H
P
-----
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
T
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
---
G
Q
-----
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
G
Q
D
E
----
E
---
E
L
F
H
S
I
R
--
M
-----
D
N
P
F
Y
P
---
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
-
V
-
R
-
G
-
D
-----
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
-
P
--------------------------------------------
Q
-
N
M
---
F
R
N
F
S
F
----------------------
559
HHSearch
64.48
57%
-130
- C2 -
-
1XJD
1
A:
[16-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
S
F
G
K
V
F
L
A
E
---
F
---
K
-
K
T
-
N
--
Q
F
F
A
I
K
A
L
K
K
D
V
V
L
M
D
-
D
D
V
E
C
T
M
V
E
K
R
V
-
L
S
L
A
W
-----
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
C
-
H
K
----
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
K
-
G
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
-
K
D
G
H
I
K
I
A
D
F
G
M
C
K
E
N
M
L
G
D
A
K
T
N
--
T
F
-
C
-
G
T
P
D
Y
I
A
P
E
I
L
L
---
G
Q
-----
K
-----
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
-
Q
S
P
F
-----
H
G
Q
D
E
----
E
---
E
L
F
H
S
I
R
--
M
-----
D
N
P
F
Y
P
---
R
---
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
R
L
G
-
V
-
R
-------
G
D
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
-
P
--------------------------------------------
Q
-
N
M
---
F
R
N
F
S
F
----------------------
560
HHSearch
64.11
45%
-106
- C2 -
-
2JDO
2
AKT2_HUMAN
A:
[7-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
N
T
------
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
A
Q
S
I
T
-----------------
M
---
F
E
D
F
D
Y
I
A
D
-------------------
72
Blastp_CBE
63.96
44%
-104
- C2 -
-
3D0E
1
AKT2_HUMAN
A:
[1-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
-
A
Q
S
I
T
I
P
P
D
--------
D
Q
R
T
H
---
F
P
Q
F
D
Y
----------------------
14
PsiBlast_PDB
63.92
48%
-81
- C2 -
-
5LI9
13
KPCI_HUMAN
A:
[3-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
-
K
T
-
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
--------
T
E
----
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
-
F
G
L
D
N
--
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
71
Blastp_CBE
63.79
44%
-102
- C2 -
-
3D0E
1
AKT2_HUMAN
B:
[1-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
-
A
Q
S
I
T
I
P
P
D
--------
D
Q
R
T
H
---
F
P
Q
F
D
Y
----------------------
69
Blastp_CBE
63.73
44%
-104
- C2 -
-
3E87
1
AKT2_HUMAN
B:
[1-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
-
A
Q
S
I
T
I
P
P
---------
D
Q
R
T
H
---
F
P
Q
F
D
Y
----------------------
70
Blastp_CBE
63.61
44%
-104
- C2 -
-
3E87
1
AKT2_HUMAN
A:
[1-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
-
A
Q
S
I
T
I
P
P
---------
D
Q
R
T
H
---
F
P
Q
F
D
Y
----------------------
44
Blastp_CBE
63.56
44%
-106
- C2 -
-
1O6K
1
AKT2_HUMAN
A:
[1-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
A
Q
S
I
T
--------------
Q
R
T
H
---
F
P
Q
F
D
Y
----------------------
65
Blastp_CBE
63.18
44%
-105
- C2 -
-
3E8D
1
AKT2_HUMAN
B:
[1-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
-
A
Q
S
I
--------------
Q
R
T
H
---
F
P
Q
F
D
Y
----------------------
67
Blastp_CBE
63.16
44%
-105
- C2 -
-
3E88
1
AKT2_HUMAN
B:
[1-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
-
A
Q
S
I
T
I
-----------
D
Q
R
T
H
---
F
P
Q
F
D
Y
----------------------
42
Blastp_CBE
63.14
43%
-104
- C2 -
-
2JDO
2
AKT2_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
A
Q
S
I
T
------------------M--
F
E
D
F
D
Y
I
---------------------
68
Blastp_CBE
63.12
44%
-105
- C2 -
-
3E88
1
AKT2_HUMAN
A:
[1-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
-
A
Q
S
I
T
I
-----------
D
Q
R
T
H
---
F
P
Q
F
D
Y
----------------------
557
HHSearch
63.08
58%
-85
- C2 -
-
3TXO
1
KPCL_HUMAN
A:
[23-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
---
V
---
K
-
E
T
-
G
--
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
-
D
D
V
E
C
T
M
T
E
K
R
I
-
L
S
L
A
R
-----
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
-
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
-
R
R
----
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
------------
C
-
G
T
P
D
Y
I
A
P
E
I
L
Q
---
E
M
-----
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
-----
E
A
E
N
E
----
D
---
D
L
F
E
A
I
L
--
N
-----
D
E
V
V
Y
P
---
T
---
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
-
S
-
L
T
Q
-
G
-
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
-
P
P
F
R
P
R
-
I
K
S
-
R
E
D
V
-
S
N
--
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
-
H
L
P
M
I
N
Q
-
D
E
---
F
R
N
F
E
Y
V
S
P
-------------------
41
Blastp_CBE
63.04
43%
-108
- C2 -
-
2JDR
1
AKT2_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
A
Q
S
I
T
------------------QEM
F
E
D
F
D
Y
I
---------------------
38
Blastp_CBE
62.91
43%
-110
- C2 -
-
2XH5
1
AKT2_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
A
Q
S
I
T
------------------QEM
F
E
D
F
D
Y
I
---------------------
66
Blastp_CBE
62.88
44%
-105
- C2 -
-
3E8D
1
AKT2_HUMAN
A:
[1-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
-
A
Q
S
I
----------------
T
H
---
F
P
Q
F
D
Y
----------------------
39
Blastp_CBE
62.83
43%
-107
- C2 -
-
2X39
1
AKT2_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
A
Q
S
I
T
------------------QEM
F
E
D
F
D
Y
I
---------------------
16
PsiBlast_PDB
62.68
48%
-84
- C2 -
-
3A8W
1
KPCI_HUMAN
A:
[6-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
-
K
T
-
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
D-------
T
E
----
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
-
F
G
L
D
N
--
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
40
Blastp_CBE
62.56
43%
-106
- C2 -
-
2UW9
1
AKT2_HUMAN
A:
[6-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
A
Q
S
I
T
------------------QEM
F
E
D
F
D
Y
I
---------------------
43
Blastp_CBE
62.55
44%
-107
- C2 -
-
1O6L
1
AKT2_HUMAN
A:
[1-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
A
K
-
D
E
V
A
H
T
V
T
E
S
R
V
-
L
Q
------
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
-
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
S
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
R
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
D
E
F
T
A
Q
S
I
T
------------------QEM
F
E
D
F
D
Y
I
---------------------
561
HHSearch
62.51
50%
-69
- C2 -
-
5LI9
13
KPCI_HUMAN
A:
[4-343]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
-
K
T
-
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
-----
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
---------------TED
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
Q
T
-
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
F
G
L
-
D
N
--
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
L
-----------------
5
PsiBlast_PDB
62.24
56%
-82
- C2 -
-
3TXO
1
KPCL_HUMAN
A:
[23-349]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
S
F
G
K
V
M
L
A
R
---
V
---
K
-
E
T
-
G
--
D
L
Y
A
V
K
V
L
K
K
D
V
I
L
Q
D
-
D
D
V
E
C
T
M
T
E
K
R
I
-
L
S
L
A
R
N
H
P
-----
F
L
T
Q
L
F
C
C
F
Q
T
P
D
-
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
S
-
R
R
----
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
K
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
H
E
G
H
C
K
L
A
D
F
G
M
C
K
E
G
I
------------
C
-
G
T
P
D
Y
I
A
P
E
I
L
Q
---
E
M
-----
L
-----
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
-
H
A
P
F
-----
E
A
E
N
E
----
D
---
D
L
F
E
A
I
L
--
N
-----
D
E
V
V
Y
P
---
T
---
W
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
R
L
G
-
S
L
T
-
Q
-
G
-
G
E
H
A
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
-
P
P
F
R
P
R
-
I
K
S
-
R
-
E
D
V
S
N
--
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
-
H
L
P
M
I
N
Q
-
D
E
---
F
R
N
F
E
Y
V
S
P
-------------------
11
PsiBlast_PDB
62.04
48%
-69
- C2 -
-
4DC2
1
KPCI_MOUSE
A:
[49-387]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
-
K
T
-
D
--
R
I
Y
A
M
R
V
V
K
K
E
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVGS--
N
T
E
----
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
-
F
G
L
D
N
--
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
565
HHSearch
61.80
50%
-119
- C2 -
-
4OTH
1
A:
[8-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
---
F
---
R
-
P
S
-
G
--
E
L
F
A
I
K
A
L
K
K
G
D
I
V
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
-
L
A
A
V
T
---
S
A
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
V
----
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
----------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
G
D
D
E
----
E
---
E
V
F
D
S
I
V
--
N
-----
D
E
V
R
Y
P
---
R
---
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
-
S
-
S
-
E
-
R
-
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
-
P
P
F
V
P
T
-
L
S
G
-
R
T
D
V
-
S
N
--
F
D
E
E
F
T
G
E
A
P
T
L
S
P
P
R
D
A
R
P
L
T
A
A
E
Q
-
A
A
---
F
L
D
F
D
F
V
A
--------------------
562
HHSearch
61.50
50%
-67
- C2 -
-
5LI1
2
KPCI_HUMAN
A:
[7-347]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
-
K
T
-
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
-----
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
-----
D
I
--------TED
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
Q
T
-
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
F
G
L
-
D
N
--
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
L
L
-----------------
74
Blastp_CBE
60.83
49%
-120
- C2 -
-
4OTH
1
A:
[9-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
---
F
---
R
-
P
S
-
G
--
E
L
F
A
I
K
A
L
K
K
G
D
I
V
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
-
L
A
--
A
V
T
S
A
G
H
P
-
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
V
----
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
----------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
G
D
D
E
----
E
---
E
V
F
D
S
I
V
--
N
-----
D
E
V
R
Y
P
---
R
---
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
-
S
-
S
-
E
-
R
-
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
-
P
P
F
V
P
T
-
L
S
G
-
R
-
T
D
V
S
N
--
F
D
E
E
F
T
G
E
A
P
T
L
P
P
R
D
A
R
-
P
L
T
A
A
E
Q
-
A
A
---
F
L
D
F
D
F
V
---------------------
19
PsiBlast_PDB
60.53
48%
-60
- C2 -
-
5LI1
2
KPCI_HUMAN
A:
[7-345]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
-
K
T
-
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI------
T
E
----
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
-
F
G
L
D
N
--
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
133
Blastp_CBE
60.50
39%
-104
- C2 -
-
2UZW
1
KAPCA_BOVIN
E:
[25-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
148
Blastp_CBE
60.37
39%
-103
- C2 -
-
2OJF
1
KAPCA_BOVIN
E:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
15
PsiBlast_PDB
60.18
48%
-64
- C2 -
-
5LIH
3
KPCI_HUMAN
A:
[2-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
-
K
T
-
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
--------
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI----
Q
N
T
E
----
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
-
F
G
L
D
N
--
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
136
Blastp_CBE
60.17
39%
-107
- C2 -
-
2UZT
1
KAPCA_BOVIN
A:
[25-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
152
Blastp_CBE
60.01
39%
-102
- C2 -
-
2F7E
1
KAPCA_BOVIN
E:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
78
Blastp_CBE
59.99
41%
-137
- C2 -
-
2R5T
1
SGK1_HUMAN
A:
[24-320]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
N
L
G
P
S
S
N
P
H
A
K
P
S
---------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
-
A
E
-
E
--
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
-
L
L
K
N
V
K
H
P
-----
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
C
----
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
H
---
K
Q
-----
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
S
R
N
T
----
A
---
E
M
Y
D
N
I
L
--
N
-----
K
P
L
Q
L
K
---
P
---
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
-
A
-
K
-
D
-
D
-
F
M
-
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
-
P
P
F
N
P
N
-
V
S
G
----------------------------------------------------------------------
150
Blastp_CBE
59.98
39%
-110
- C2 -
-
2F7Z
1
KAPCA_BOVIN
E:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
135
Blastp_CBE
59.92
39%
-104
- C2 -
-
2UZU
1
KAPCA_BOVIN
E:
[25-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
151
Blastp_CBE
59.65
39%
-98
- C2 -
-
2F7X
1
KAPCA_BOVIN
E:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
149
Blastp_CBE
59.38
39%
-103
- C2 -
-
2OH0
1
KAPCA_BOVIN
E:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
77
Blastp_CBE
59.30
41%
-126
- C2 -
-
3HDM
1
SGK1_HUMAN
A:
[23-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
I
N
L
G
P
S
S
N
P
H
A
K
P
S
---------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
-
A
E
-
E
--
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
-
L
L
K
N
V
K
H
P
-----
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
C
----
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
H
---
K
Q
-----
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
S
R
N
T
----
A
---
E
M
Y
D
N
I
L
--
N
-----
K
P
L
Q
L
K
---
P
---
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
-
A
-
K
-
D
-
D
-
F
M
-
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
-
P
P
F
N
P
N
-
V
S
G
----------------------------------------------------------------------
134
Blastp_CBE
59.26
39%
-99
- C2 -
-
2UZV
1
KAPCA_BOVIN
A:
[25-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
---
V
K
G
R
T
W
--
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
73
Blastp_CBE
59.25
49%
-124
- C2 -
-
4OTI
1
A:
[9-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
---
F
---
R
-
P
S
-
G
--
E
L
F
A
I
K
A
L
K
K
G
D
I
V
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
-
L
A
--
A
V
T
S
A
G
H
P
-
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
V
----
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
G
D
D
E
----
E
---
E
V
F
D
S
I
V
--
N
-----
D
E
V
R
Y
P
---
R
---
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
-
S
-
S
-
E
-
R
-
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
-
P
P
F
V
P
T
-
L
S
G
-
R
-
T
D
V
S
N
--
F
D
E
E
F
T
G
E
A
P
T
L
P
P
R
D
A
R
-
P
L
T
A
A
E
Q
-
A
A
---
F
L
D
F
D
F
V
---------------------
13
PsiBlast_PDB
59.17
48%
-63
- C2 -
-
3ZH8
4
KPCI_HUMAN
A:
[2-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
-
K
T
-
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV----
N
T
E
----
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
------------------
Q
L
T
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
76
Blastp_CBE
59.08
41%
-135
- C2 -
-
3HDN
1
SGK1_HUMAN
A:
[24-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
N
L
G
P
S
S
N
P
H
A
K
P
S
---------------------
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
-
A
E
-
E
--
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
-
L
L
K
N
V
K
H
P
-----
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
C
----
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
H
---
K
Q
-----
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
S
R
N
T
----
A
---
E
M
Y
D
N
I
L
--
N
-----
K
P
L
Q
L
K
---
P
---
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
-
A
-
K
-
D
-
D
-
F
M
-
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
-
P
P
F
N
P
---------------------------------------------------------------------------
18
PsiBlast_PDB
57.33
48%
-59
- C2 -
-
6ILZ
1
KPCI_HUMAN
A:
[11-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
--------
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
S
--
T
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI-------
E
----
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
-
F
G
L
D
N
--
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
60
Blastp_CBE
56.82
45%
-41
- C2 -
-
4GV1
5
AKT1_HUMAN
A:
[3-319]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
54
Blastp_CBE
56.38
45%
-43
- C2 -
-
3QKK
1
AKT1_HUMAN
A:
[5-339]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
47
Blastp_CBE
56.14
45%
-37
- C2 -
-
3CQW
1
AKT1_HUMAN
A:
[6-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
53
Blastp_CBE
55.91
45%
-35
- C2 -
-
3QKL
1
AKT1_HUMAN
A:
[5-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
55
Blastp_CBE
55.76
45%
-37
- C2 -
-
3OW4
1
AKT1_HUMAN
B:
[5-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
45
Blastp_CBE
55.70
45%
-34
- C2 -
-
3MVH
1
AKT1_HUMAN
A:
[7-336]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
59
Blastp_CBE
55.62
45%
-37
- C2 -
-
6CCY
1
AKT1_HUMAN
A:
[4-331]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
S
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
P
-
S
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
V
D
T
-
R
Y
--
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
52
Blastp_CBE
55.62
45%
-41
- C2 -
-
3QKM
1
AKT1_HUMAN
A:
[5-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
49
Blastp_CBE
55.57
45%
-37
- C2 -
-
4EKL
1
AKT1_HUMAN
A:
[5-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
57
Blastp_CBE
55.53
45%
-36
- C2 -
-
3OCB
1
AKT1_HUMAN
B:
[5-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
50
Blastp_CBE
55.38
45%
-40
- C2 -
-
4EKK
1
AKT1_HUMAN
B:
[5-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
75
Blastp_CBE
55.34
49%
-87
- C2 -
-
4OTG
1
A:
[9-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
L
E
D
F
K
F
L
A
V
L
G
R
G
H
F
G
K
V
L
L
S
E
---
F
---
R
-
P
S
-
G
--
E
L
F
A
I
K
A
L
K
K
G
D
I
V
A
R
-
D
E
V
E
S
L
M
C
E
K
R
I
-
L
A
--
A
V
T
S
A
G
H
P
-
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
V
----
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
Y
V
K
I
A
D
F
G
L
C
K
E
G
M
G
Y
G
D
R
T
---
S
F
-
C
-
G
T
P
E
F
L
A
P
E
V
L
T
---
D
T
-----
S
-----
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
-
E
S
P
F
-----
P
G
D
D
E
----
E
---
E
V
F
D
S
I
V
--
N
-----
D
E
V
R
Y
P
---
R
---
F
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
-
S
-
S
-
E
-
R
-
D
A
E
D
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
-
P
P
F
V
P
T
-
L
S
----------------
T
G
E
A
P
T
L
P
P
R
D
A
R
-
P
L
T
A
A
E
Q
-
A
A
---
F
L
D
F
D
F
V
---------------------
48
Blastp_CBE
55.21
45%
-35
- C2 -
-
3CQU
1
AKT1_HUMAN
A:
[6-340]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
46
Blastp_CBE
55.12
45%
-37
- C2 -
-
3MV5
1
AKT1_HUMAN
A:
[6-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
508
Blastp_CBE
54.89
36%
-104
- C2 -
-
2R7B
2
PDPK1_HUMAN
A:
[34-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
-----------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
56
Blastp_CBE
54.88
45%
-34
- C2 -
-
3OW4
1
AKT1_HUMAN
A:
[5-332]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
51
Blastp_CBE
54.68
45%
-30
- C2 -
-
4EKK
1
AKT1_HUMAN
A:
[5-330]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
58
Blastp_CBE
54.62
45%
-33
- C2 -
-
3OCB
1
AKT1_HUMAN
A:
[5-334]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
P
D
Q
-------------------------------------------
82
Blastp_CBE
54.07
46%
-52
- C2 -
-
6HHJ
1
AKT1_HUMAN
A:
[144-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
D
G
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
------------------------------------------------------
81
Blastp_CBE
53.81
46%
-56
- C2 -
-
6S9W
1
?
A:
[144-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
K
-
D
E
V
A
H
T
L
T
E
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
--
A
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
------------------------------------------------------
503
Blastp_CBE
53.60
36%
-100
- C2 -
-
3QCX
6
PDPK1_HUMAN
A:
[34-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
35
Blastp_CBE
53.48
49%
-70
- C2 -
-
3A8W
1
KPCI_HUMAN
B:
[6-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
-
K
T
-
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
---
G
D
T
T
---
S
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI-------
E
----
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
-
F
G
L
D
N
--
F
D
S
Q
F
T
N
-
E
P
V
Q
L
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
516
Blastp_CBE
53.38
36%
-99
- C2 -
-
3RWP
5
PDPK1_HUMAN
A:
[33-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
511
Blastp_CBE
53.32
36%
-105
- C2 -
-
1UU3
9
PDPK1_HUMAN
A:
[31-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
498
Blastp_CBE
53.29
33%
-49
- C2 -
-
4AW2
3
MRCKA_RAT
A:
[70-405]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
H
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
---
L
---
K
-
N
A
-
D
--
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
-
L
V
------
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
-
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
----
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
-
H
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
-
M
N
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
D
G
T
V
Q
S
--
S
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
---
A
M
-----
E
GGKGR
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
A
E
S
L
----
V
---
E
T
Y
G
K
I
M
--
N
HKERF
Q
F
P
T
Q
V
---
T
---
D
V
S
E
N
A
K
D
L
I
R
R
L
I
C
S
R
E
-
H
R
L
G
-
Q
-----
N
-
G
I
E
D
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
R
N
C
E
A
P
Y
I
P
E
V
S
S
-
P
T
D
-
T
-
S
N
-
F
D
--
V
D
-------------------
S
G
-
H
H
-
L
P
---
F
V
G
F
T
Y
T
S
--------------------
526
Blastp_CBE
53.27
33%
-40
- C2 -
-
5OTF
3
MRCKB_HUMAN
A:
[72-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
---
M
---
K
-
N
T
-
E
--
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
-
L
V
------
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
----
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
---
A
M
EDGMG
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
A
E
S
L
----
V
---
E
T
Y
G
K
I
M
NH
E
-----
E
R
F
Q
F
P
---
S
HVT
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
-
R
R
L
G
-
Q
-----
N
-
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
-
P
S
D
-
T
-
S
N
-
F
D
--
V
--------
E
I
L
P
P
G
S
H
T
-
G
F
S
G
L
-
H
-
L
P
---
F
I
G
F
T
F
T
T
--------------------
538
Blastp_CBE
53.26
35%
-102
- C2 -
-
5LVP
1
PDPK1_HUMAN
C:
[33-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
G
---
L
I
F
A
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
536
Blastp_CBE
53.24
33%
-44
- C2 -
-
3TKU
3
MRCKB_HUMAN
A:
[86-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
---
M
---
K
-
N
T
-
E
--
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
-
L
V
------
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
----
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
---
A
M
EDGMG
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
A
E
S
L
----
V
---
E
T
Y
G
K
I
M
NH
E
-----
E
R
F
Q
F
P
---
S
HVT
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
-
R
R
L
G
-
Q
-----
N
-
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
-
P
S
D
-
T
-
S
N
-
F
D
--
V
--------------------
S
G
L
-
H
-
L
P
---
F
I
G
F
T
F
T
---------------------
494
Blastp_CBE
53.16
36%
-98
- C2 -
-
2PE0
4
PDPK1_HUMAN
A:
[7-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
487
Blastp_CBE
53.15
35%
-94
- C2 -
-
1UU9
8
PDPK1_HUMAN
A:
[2-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
492
Blastp_CBE
53.12
36%
-98
- C2 -
-
2PE2
9
PDPK1_HUMAN
A:
[7-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
566
HHSearch
53.09
43%
-73
- C2 -
-
3HDM
1
SGK1_HUMAN
A:
[34-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
-
A
E
-
E
--
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
N
------
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
C
----
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
H
---
K
Q
-----
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
S
R
N
T
----
A
---
E
M
Y
D
N
I
L
--
N
-----
K
P
L
Q
L
K
---
P
---
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
-
A
-
K
---
D
-
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
-
P
P
F
N
P
N
-
V
S
G
----------------------------------------------------------------------
518
Blastp_CBE
53.01
36%
-95
- C2 -
-
3QC4
1
PDPK1_HUMAN
A:
[36-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
-------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
A
---
A
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
506
Blastp_CBE
52.97
36%
-102
- C2 -
-
3IOP
1
PDPK1_HUMAN
A:
[34-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
83
Blastp_CBE
52.90
46%
-50
- C2 -
-
6HHI
1
AKT1_HUMAN
A:
[144-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
------------------
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
---
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
------------------------------------------------------
567
HHSearch
52.70
43%
-73
- C2 -
-
2R5T
1
SGK1_HUMAN
A:
[34-320]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
A
K
P
S
D
F
H
F
L
K
V
I
G
K
G
S
F
G
K
V
L
L
A
R
---
H
---
K
-
A
E
-
E
--
V
F
Y
A
V
K
V
L
Q
K
K
A
I
L
--------------
V
L
L
K
N
------
V
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
E
-
R
C
----
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
L
-
N
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
S
Q
G
H
I
V
L
T
D
F
G
L
C
K
E
N
I
E
H
N
S
T
T
S
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
H
---
K
Q
-----
P
-----
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
-
L
P
P
F
-----
Y
S
R
N
T
----
A
---
E
M
Y
D
N
I
L
--
N
-----
K
P
L
Q
L
K
---
P
---
N
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
R
L
G
-
A
-
K
---
D
-
D
F
M
E
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
-
P
P
F
N
P
N
-
V
S
G
----------------------------------------------------------------------
504
Blastp_CBE
52.56
36%
-101
- C2 -
-
3QCS
5
PDPK1_HUMAN
A:
[34-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
517
Blastp_CBE
52.45
36%
-99
- C2 -
-
3QC4
1
PDPK1_HUMAN
B:
[36-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
---------
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
-------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
A
---
A
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
535
Blastp_CBE
52.41
33%
-42
- C2 -
-
3TKU
3
MRCKB_HUMAN
B:
[86-420]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
---
M
---
K
-
N
T
-
E
--
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
-
L
V
------
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
----
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
---
A
M
EDGMG
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
A
E
S
L
----
V
---
E
T
Y
G
K
I
M
NH
E
-----
E
R
F
Q
F
P
---
S
HVT
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
-
R
R
L
G
-
Q
-----
N
-
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
-
P
S
D
-
T
-
S
N
-
F
D
----------------------
F
S
G
L
-
H
-
L
P
---
F
I
G
F
T
F
T
---------------------
497
Blastp_CBE
52.36
36%
-98
- C2 -
-
3NUN
5
PDPK1_HUMAN
A:
[15-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
87
Blastp_CBE
52.34
46%
-53
- C2 -
-
4EJN
3
AKT1_HUMAN
A:
[144-438]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
--------------
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
-----
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
-----------------------------------------------------------
501
Blastp_CBE
52.28
36%
-98
- C2 -
-
3QD0
6
PDPK1_HUMAN
A:
[34-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
--------------
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
493
Blastp_CBE
52.26
36%
-98
- C2 -
-
2PE1
5
PDPK1_HUMAN
A:
[7-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
533
Blastp_CBE
52.25
33%
-41
- C2 -
-
3QFV
2
MRCKB_HUMAN
A:
[70-405]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
---
M
---
K
-
N
T
-
E
--
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
-
L
V
------
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
----
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
---
A
M
EDGMG
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
A
E
S
L
----
V
---
E
T
Y
G
K
I
M
NH
E
-----
E
R
F
Q
F
P
---
S
HVT
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
-
R
R
L
G
-
Q
-----
N
-
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
-
P
S
D
-
T
-
S
N
-
F
D
--
V
--------------------
S
G
L
-
H
-
L
P
---
F
I
G
F
T
F
T
T
--------------------
449
Blastp_CBE
52.10
37%
-108
- C2 -
-
5LOH
2
GWL_HUMAN
A:
[33-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
I
E
E
F
S
I
V
K
P
I
S
----
G
K
V
Y
L
G
Q
---
K
---
G
-
G
-----
K
L
Y
A
V
K
V
V
K
K
A
D
M
-----------------
L
A
L
S
------
K
S
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
-
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
Y
-
G
Y
----
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
R
H
-
G
I
I
H
R
D
L
K
P
D
N
M
L
I
S
-
N
E
G
H
I
K
L
T
D
F
G
L
S
K
-------------
F
-
C
-
G
T
P
D
Y
L
A
P
E
L
L
L
---
G
R
-----
A
-----
H
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
-
I
P
P
F
-----
N
D
E
T
P
----
Q
---
Q
V
F
Q
N
I
L
--
K
-----
R
D
I
P
W
P
EGE
E
---
K
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
R
A
G
-
M
---------
K
E
L
K
R
H
P
L
F
S
D
V
D
---
W
E
N
L
Q
H
Q
T
M
---
P
F
I
P
Q
-
P
------------------------------------------------------------------------
495
Blastp_CBE
52.08
36%
-96
- C2 -
-
1Z5M
4
PDPK1_HUMAN
A:
[7-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
505
Blastp_CBE
52.06
36%
-100
- C2 -
-
3QCQ
5
PDPK1_HUMAN
A:
[34-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
573
Fugue
52.04
36%
-51
- C2 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
E
R
P
A
P
L
N
N
F
S
V
--
A
---
Q
C
Q
L
M
K
T
----
E
R
P
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
T
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
V
L
-------------------------
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
--------------------
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
--
Y
F
----------------------------------------------------------
507
Blastp_CBE
51.98
36%
-103
- C2 -
-
3ION
1
PDPK1_HUMAN
A:
[34-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
------------
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
529
Blastp_CBE
51.91
33%
-40
- C2 -
-
4UAK
2
MRCKB_HUMAN
A:
[72-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
---
M
---
K
-
N
T
-
E
--
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
-
L
V
------
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
----
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
---
A
M
EDGMG
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
A
E
S
L
----
V
---
E
T
Y
G
K
I
M
NH
E
-----
E
R
F
Q
F
P
---
S
HVT
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
-
R
R
L
G
-
Q
-----
N
-
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
-
P
S
D
-
T
-
S
N
-
F
D
-----------------
S
H
T
-
G
F
S
G
L
-
H
-
L
P
---
F
I
G
F
T
F
T
T
--------------------
33
Blastp_CBE
51.71
49%
-59
- C2 -
-
6ILZ
1
KPCI_HUMAN
C:
[11-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
--------
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
---
S
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI------------
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
-
F
G
L
D
N
--
F
D
S
Q
F
---
E
P
V
Q
L
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
85
Blastp_CBE
51.70
46%
-45
- C2 -
-
6HHG
1
AKT1_HUMAN
A:
[144-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
--------------------------
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
---
T
M
K
--
T
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
------------------------------------------------------
528
Blastp_CBE
51.69
33%
-37
- C2 -
-
4UAL
2
MRCKB_HUMAN
A:
[72-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
---
M
---
K
-
N
T
-
E
--
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
-
L
V
------
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
----
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
-----
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
---
A
M
EDG--
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
A
E
S
L
----
V
---
E
T
Y
G
K
I
M
NH
E
-----
E
R
F
Q
F
P
---
S
HVT
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
-
R
R
L
G
-
Q
-----
N
-
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
-
P
S
D
-
T
-
S
N
-
F
D
--
V
---------
I
L
P
P
--
H
T
-
G
F
S
G
L
-
H
-
L
P
---
F
I
G
F
T
F
T
T
--------------------
91
Blastp_CBE
51.58
40%
-6
- C2 -
-
4L43
1
KS6B1_HUMAN
A:
[12-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
------
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
---------------
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
-
L
Q
S
-
E
-
E
D
V
S
Q
--
F
D
S
K
F
T
R
Q
T
P
V
-----------
S
A
N
Q
-
V
----
F
L
G
F
A
Y
V
A
P
-------------------
448
Blastp_CBE
51.57
37%
-104
- C2 -
-
5LOH
3
GWL_HUMAN
B:
[33-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
I
E
E
F
S
I
V
K
P
I
S
R
G
A
F
G
K
V
Y
L
G
Q
---
K
---
G
-
G
-----
K
L
Y
A
V
K
V
V
K
K
A
D
M
I
N
K
---------------
A
L
S
------
K
S
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
-
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
Y
-
G
Y
----
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
R
H
-
G
I
I
H
R
D
L
K
P
D
N
M
L
I
S
-
N
E
G
H
I
K
L
T
D
F
G
L
-------------------
G
T
P
D
Y
L
A
P
E
L
L
L
---
G
R
-----
A
-----
H
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
-
I
P
P
F
-----
N
D
E
T
P
----
Q
---
Q
V
F
Q
N
I
L
--
K
-----
R
D
I
P
W
P
EGE
E
---
K
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
R
A
G
-
M
---------
K
E
L
K
R
H
P
L
F
S
D
V
D
---
W
E
N
L
Q
H
Q
T
M
---
P
F
I
P
Q
-
P
------------------------------------------------------------------------
80
Blastp_CBE
51.52
46%
-48
- C2 -
-
6S9X
1
?
A:
[144-443]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
------------------
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
I
K
---------
F
-
C
-
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
E
E
F
T
------------------------------------------------------
532
Blastp_CBE
51.47
33%
-42
- C2 -
-
3QFV
3
MRCKB_HUMAN
B:
[70-405]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
---
M
---
K
-
N
T
-
E
--
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
-
L
V
------
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
----
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
---
A
M
EDGMG
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
A
E
S
L
----
V
---
E
T
Y
G
K
I
M
NH
E
-----
E
R
F
Q
F
P
---
S
HVT
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
-
R
R
L
G
-
Q
-----
N
-
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
-
P
S
D
-
T
-
S
N
-
F
D
---------------------
G
F
S
G
L
-
H
-
L
P
---
F
I
G
F
T
F
T
T
--------------------
499
Blastp_CBE
51.46
36%
-98
- C2 -
-
3QD4
1
PDPK1_HUMAN
A:
[34-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
--------------
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
530
Blastp_CBE
51.41
36%
-76
- C2 -
-
3NAY
1
PDPK1_HUMAN
B:
[30-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------A-
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
31
Blastp_CBE
51.30
49%
-71
- C2 -
-
6ILZ
1
KPCI_HUMAN
G:
[11-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
--------
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
---
S
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIV-----------
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
-----
G
L
D
N
--
F
D
S
Q
F
T
---
P
V
Q
L
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
524
Blastp_CBE
51.29
36%
-100
- C2 -
-
3NAX
1
PDPK1_HUMAN
A:
[30-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
K
Q
A
R
---------
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
527
Blastp_CBE
51.25
33%
-30
- C2 -
-
5OTE
2
MRCKB_HUMAN
A:
[72-407]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
H
R
E
D
F
E
I
I
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
---
M
---
K
-
N
T
-
E
--
R
I
Y
A
M
K
I
L
N
K
W
E
M
L
K
R
-
A
E
T
A
C
F
R
E
E
R
D
V
-
L
V
------
N
G
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
----
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
L
-
H
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
-
V
N
G
H
I
R
L
A
D
F
G
S
C
L
K
M
N
D
D
G
T
V
Q
S
--
S
V
-
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
---
A
M
EDG--
K
-----
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
-
E
T
P
F
-----
Y
A
E
S
L
----
V
---
E
T
Y
G
K
I
M
NH
E
-----
E
R
F
Q
F
P
---
S
HVT
D
V
S
E
E
A
K
D
L
I
Q
R
L
I
C
S
R
E
-
R
R
L
G
-
Q
-----
N
-
G
I
E
D
F
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
R
N
L
E
A
P
Y
I
P
D
V
S
S
-
P
S
D
-
T
-
S
N
-
F
D
------------
I
L
P
P
G
S
H
T
-
G
F
S
G
L
-
H
-
L
P
---
F
I
G
F
T
F
T
T
--------------------
29
Blastp_CBE
51.20
49%
-64
- C2 -
-
3ZH8
5
KPCI_HUMAN
B:
[2-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
-
K
T
-
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
---
S
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DIVG----
T
E
----
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
-
F
----------
F
T
N
-------
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
93
Blastp_CBE
50.96
40%
-8
- C2 -
-
4L46
1
KS6B1_HUMAN
A:
[12-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
------
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
----
H
--
T
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
-----
E
-
E
D
V
S
Q
--
F
D
S
K
F
T
R
Q
T
P
V
--------------
Q
-
V
----
F
L
G
F
-
Y
V
A
P
-------------------
92
Blastp_CBE
50.87
40%
-2
- C2 -
-
4L45
1
KS6B1_HUMAN
A:
[12-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
------
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
---------------
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
-
L
Q
S
-
E
-
E
D
V
S
Q
--
F
D
S
K
F
T
R
Q
T
P
V
----------
E
S
A
N
Q
-
V
----
F
L
G
F
E
Y
V
A
P
-------------------
523
Blastp_CBE
50.64
36%
-70
- C2 -
-
2XCH
7
PDPK1_HUMAN
A:
[31-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------A-
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
531
Blastp_CBE
50.58
36%
-78
- C2 -
-
3NAY
1
PDPK1_HUMAN
A:
[30-305]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------A-
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
79
Blastp_CBE
50.64
46%
-59
- C2 -
-
3O96
1
AKT1_HUMAN
A:
[116-432]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
A
-----------
N
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
------------------
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
------------------------------------------------------------------------
509
Blastp_CBE
50.61
36%
-77
- C2 -
-
1UU8
7
PDPK1_HUMAN
A:
[31-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------A-
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
90
Blastp_CBE
50.60
40%
-2
- C2 -
-
4L44
1
KS6B1_HUMAN
A:
[12-345]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
------
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
-----
H
--
T
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
-
L
Q
S
-
E
-
E
D
V
S
Q
---
D
S
K
F
T
R
Q
T
-----------
S
E
S
A
N
Q
-
V
----
F
L
G
F
A
Y
V
A
P
-------------------
30
Blastp_CBE
50.59
49%
-66
- C2 -
-
5LIH
3
KPCI_HUMAN
B:
[2-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
L
Q
D
F
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
---
K
-
K
T
-
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
----------
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
---
S
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI-------
E
----
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
-
F
G
L
D
N
--
F
D
S
Q
F
T
N
-
E
P
V
Q
L
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
84
Blastp_CBE
50.58
46%
-45
- C2 -
-
6HHH
1
AKT1_HUMAN
A:
[144-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
---------------
R
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
E
G
---------------
G
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
----------------------------------------------------------
88
Blastp_CBE
50.52
46%
-54
- C2 -
-
5KCV
1
AKT1_HUMAN
A:
[158-452]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
------------------
V
-
L
Q
------
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
--------------------
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
-----------------------------------------------------------
534
Blastp_CBE
50.40
35%
-70
- C2 -
-
2XCK
5
PDPK1_HUMAN
A:
[31-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
T
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------A-
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
86
Blastp_CBE
50.13
46%
-49
- C2 -
-
6HHF
1
AKT1_HUMAN
A:
[113-439]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
---
E
---
K
-
A
T
-
G
--
R
Y
Y
A
M
K
I
L
K
K
E
V
I
--------------------------
S
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
-
R
V
----
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
-
K
D
G
H
I
K
I
T
D
F
G
L
C
K
------------------
T
P
E
Y
L
A
P
E
V
L
E
---
D
N
-----
D
-----
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
-
R
L
P
F
-----
Y
N
Q
D
H
----
E
---
K
L
F
E
L
I
L
--
M
-----
E
E
I
R
F
P
---
R
---
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
G
-
G
-
G
-
S
-
E
-
D
A
K
E
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
-
P
P
F
K
P
Q
-
V
T
S
-
E
-
T
D
-
T
R
Y-
F
D
----------------------------------------------------------
514
Blastp_CBE
49.79
36%
-73
- C2 -
-
3SC1
3
PDPK1_HUMAN
A:
[33-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
-------A-
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
32
Blastp_CBE
49.64
49%
-61
- C2 -
-
6ILZ
1
KPCI_HUMAN
E:
[12-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
V
I
G
R
G
S
Y
A
K
V
L
L
V
R
---
L
--------
D
--
R
I
Y
A
M
K
V
V
K
K
E
L
V
N
D
D
-
E
D
I
D
W
V
Q
T
E
K
H
V
-
F
E
Q
A
S
N
H
P
-----
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
Q
-
R
K
----
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
R
-
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
-
S
E
G
H
I
K
L
T
D
Y
G
M
C
K
E
G
L
R
P
G
D
T
T
---
S
F
-
C
-
G
T
P
N
Y
I
A
P
E
I
L
R
---
G
E
-----
D
-----
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
-
R
S
P
F
DI------------
D
---
Y
L
F
Q
V
I
L
--
E
-----
K
Q
I
R
I
P
---
R
---
S
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
L
G
-
C
-
H
-
P
-
Q
T
G
F
A
D
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
-
P
P
F
K
P
N
-
I
S
G
-
E
-
F
G
L
D
N
--
F
D
S
Q
F
T
---
P
V
Q
L
P
D
D
D
D
-
I
V
R
K
I
D
Q
-
S
E
---
F
E
G
F
E
Y
I
N
P
-------------------
154
Blastp_CBE
49.56
39%
-62
- C2 -
-
1YDS
1
KAPCA_BOVIN
E:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
219
Blastp_CBE
49.54
38%
-64
- C2 -
-
4NTT
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
297
Blastp_CBE
49.44
38%
-58
- C2 -
-
5MHI
4
KAPCA_CRIGR
A:
[35-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
549
Blastp_CBE
49.26
35%
-99
- C2 -
-
4AW1
4
PDPK1_HUMAN
A:
[33-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
------
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
G
---
L
I
F
A
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
293
Blastp_CBE
49.16
38%
-60
- C2 -
-
5N32
3
KAPCA_CRIGR
A:
[35-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
-
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
204
Blastp_CBE
49.17
39%
-58
- C2 -
-
6C0U
4
KAPCA_HUMAN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
142
Blastp_CBE
49.16
39%
-56
- C2 -
-
4AXA
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
365
Blastp_CBE
49.15
38%
-61
- C2 -
-
2JDS
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
525
Blastp_CBE
49.13
36%
-55
- C2 -
-
2BIY
8
PDPK1_HUMAN
A:
[31-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
K
Q
A
R
AN
A
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
177
Blastp_CBE
49.08
39%
-57
- C2 -
-
3DND
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
286
Blastp_CBE
49.05
39%
-57
- C2 -
-
2UW5
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
295
Blastp_CBE
49.01
38%
-56
- C2 -
-
5N1E
4
KAPCA_CRIGR
A:
[34-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
432
Blastp_CBE
49.02
38%
-58
- C2 -
-
5N39
5
KAPCA_CRIGR
A:
[35-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
267
Blastp_CBE
49.00
38%
-62
- C2 -
-
2C1B
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
435
Blastp_CBE
48.92
38%
-55
- C2 -
-
5N33
3
KAPCA_CRIGR
A:
[35-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
257
Blastp_CBE
49.01
38%
-59
- C2 -
-
1Q8U
3
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
153
Blastp_CBE
49.00
39%
-59
- C2 -
-
1YDT
1
KAPCA_BOVIN
E:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
198
Blastp_CBE
48.99
38%
-63
- C2 -
-
5BX7
4
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
188
Blastp_CBE
48.97
38%
-61
- C2 -
-
4UJ1
2
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
439
Blastp_CBE
48.87
38%
-56
- C2 -
-
5N1L
4
KAPCA_CRIGR
A:
[35-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
372
Blastp_CBE
48.95
38%
-62
- C2 -
-
4C38
4
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
107
Blastp_CBE
48.93
44%
7
- C2 -
-
4NUS
1
KS6A3_HUMAN
A:
[30-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
I--
S
-
G
S
-
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
-
D
R
V
R
-
T
K
M
E
R
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
--
S
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
A
-
G
-
P
-
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
-
P
P
F
K
P
--
A
T
G
-
R
-
P
E
-
D
---------------------------------------------------------------
385
Blastp_CBE
48.92
38%
-58
- C2 -
-
6I2H
1
?
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
376
Blastp_CBE
48.91
38%
-59
- C2 -
-
4C35
2
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
226
Blastp_CBE
48.87
39%
-59
- C2 -
-
4Z84
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
430
Blastp_CBE
48.78
38%
-57
- C2 -
-
5N3B
2
KAPCA_CRIGR
A:
[36-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
288
Blastp_CBE
48.85
39%
-55
- C2 -
-
2UW0
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
221
Blastp_CBE
48.84
39%
-54
- C2 -
-
4Z83
2
KAPCA_BOVIN
E:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
471
Blastp_CBE
48.70
39%
-35
- C2 -
-
3T8O
2
GRK1_BOVIN
A:
[192-481]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
---
M
---
K
-
A
T
-
G
--
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
------
K
V
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
-
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
-
D
E
DNPG
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
--
G
Y
-
A
-
G
T
P
G
F
M
A
P
E
L
L
L
---
G
E
-----
E
-----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
-
R
G
P
F
-----
R
A
R
G
E
KVEN
K
---
E
L
K
Q
R
V
L
--
E
-----
Q
A
V
T
Y
P
---
D
---
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
-
F
-
R
-
D
-
G
-
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
R
Q
L
E
A
G
M
L
T
-
P
P
F
V
P
---------------------------------------------------------------------------
281
Blastp_CBE
48.79
39%
-58
- C2 -
-
2VO3
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
360
Blastp_CBE
48.78
38%
-55
- C2 -
-
4DG3
1
KAPCA_MOUSE
E:
[55-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
436
Blastp_CBE
48.76
38%
-64
- C2 -
-
5N1O
2
KAPCA_CRIGR
A:
[33-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
-
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
309
Blastp_CBE
48.71
38%
-55
- C2 -
-
5LCQ
3
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
273
Blastp_CBE
48.75
38%
-54
- C2 -
-
2GNI
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
364
Blastp_CBE
48.68
38%
-60
- C2 -
-
3ZO1
7
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
363
Blastp_CBE
48.74
38%
-56
- C2 -
-
3ZO3
9
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
144
Blastp_CBE
48.73
39%
-55
- C2 -
-
2UW4
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
-
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
119
Blastp_CBE
48.71
42%
-6
- C2 -
-
4L3J
1
KS6B1_HUMAN
A:
[20-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
------
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
---------------------------------------------------------------------------
201
Blastp_CBE
48.70
38%
-58
- C2 -
-
3VQH
2
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
193
Blastp_CBE
48.68
38%
-56
- C2 -
-
3OVV
2
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
236
Blastp_CBE
48.67
38%
-60
- C2 -
-
1XH6
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
304
Blastp_CBE
48.62
38%
-57
- C2 -
-
5M0C
3
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
301
Blastp_CBE
48.62
38%
-55
- C2 -
-
5M6V
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
254
Blastp_CBE
48.65
38%
-61
- C2 -
-
1SVG
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
373
Blastp_CBE
48.58
38%
-58
- C2 -
-
4C37
2
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
209
Blastp_CBE
48.64
38%
-58
- C2 -
-
3IDC
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
428
Blastp_CBE
48.55
38%
-55
- C2 -
-
5N3D
2
KAPCA_CRIGR
A:
[35-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
438
Blastp_CBE
48.63
38%
-59
- C2 -
-
5N1M
3
KAPCA_CRIGR
A:
[35-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
277
Blastp_CBE
48.62
38%
-56
- C2 -
-
2GNJ
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
218
Blastp_CBE
48.61
38%
-64
- C2 -
-
4NTT
1
KAPCA_MOUSE
B:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
117
Blastp_CBE
48.60
41%
-9
- C2 -
-
3WE4
1
KS6B1_HUMAN
A:
[21-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
E
------
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
--
V
T
H
---
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
-
L
Q
-----------------------------------------------------------------------
233
Blastp_CBE
48.58
38%
-59
- C2 -
-
4IJ9
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
174
Blastp_CBE
48.58
39%
-60
- C2 -
-
4YXS
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
343
Blastp_CBE
48.57
38%
-56
- C2 -
-
4IB1
1
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
253
Blastp_CBE
48.56
38%
-58
- C2 -
-
1VEB
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
407
Blastp_CBE
48.55
38%
-57
- C2 -
-
5OT3
3
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
537
Blastp_CBE
48.42
35%
-85
- C2 -
-
5LVP
1
PDPK1_HUMAN
D:
[33-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
G
---
L
I
F
A
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
268
Blastp_CBE
48.52
38%
-60
- C2 -
-
2C1A
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
266
Blastp_CBE
48.49
38%
-64
- C2 -
-
2VO7
2
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
434
Blastp_CBE
48.41
38%
-57
- C2 -
-
5N36
2
KAPCA_CRIGR
A:
[35-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
377
Blastp_CBE
48.50
38%
-60
- C2 -
-
4C34
3
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
--
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
228
Blastp_CBE
48.49
38%
-57
- C2 -
-
2GU8
1
KAPCA_HUMAN
A:
[21-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
E
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
366
Blastp_CBE
48.48
38%
-59
- C2 -
-
1XH7
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
328
Blastp_CBE
48.47
38%
-56
- C2 -
-
4DH3
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
391
Blastp_CBE
48.44
38%
-61
- C2 -
-
6ERW
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
---
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
431
Blastp_CBE
48.34
38%
-58
- C2 -
-
5N3A
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
180
Blastp_CBE
48.42
38%
-58
- C2 -
-
5UZK
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
291
Blastp_CBE
48.41
38%
-57
- C2 -
-
5N7U
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
310
Blastp_CBE
48.36
38%
-58
- C2 -
-
5LCP
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
346
Blastp_CBE
48.33
38%
-59
- C2 -
-
4IAY
1
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
282
Blastp_CBE
48.36
39%
-57
- C2 -
-
2VNY
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
306
Blastp_CBE
48.38
38%
-61
- C2 -
-
5LCU
5
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
238
Blastp_CBE
48.36
38%
-58
- C2 -
-
1SVH
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
393
Blastp_CBE
48.37
38%
-58
- C2 -
-
6ERT
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
114
Blastp_CBE
48.36
41%
-10
- C2 -
-
3WF7
2
KS6B1_HUMAN
A:
[21-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
E
------
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
--
V
T
H
---
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
-
L
Q
-----------------------------------------------------------------------
276
Blastp_CBE
48.33
38%
-59
- C2 -
-
2GNL
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
345
Blastp_CBE
48.35
38%
-60
- C2 -
-
4IAZ
1
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
368
Blastp_CBE
48.28
38%
-62
- C2 -
-
3BWJ
2
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
239
Blastp_CBE
48.33
38%
-56
- C2 -
-
5VIB
1
KAPCA_BOVIN
A:
[40-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
-----
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
146
Blastp_CBE
48.34
39%
-60
- C2 -
-
2JDV
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
200
Blastp_CBE
48.33
38%
-58
- C2 -
-
4UJB
3
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
465
Blastp_CBE
48.23
39%
-21
- C2 -
-
4YHJ
1
GRK4_HUMAN
A:
[187-470]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
H
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
---
V
---
R
-
A
T
-
G
--
K
M
Y
A
C
K
K
L
Q
K
K
R
I
K
K
R
-
K
G
E
A
M
A
L
N
E
K
R
I
-
L
E
------
K
V
Q
S
R
F
V
V
S
L
A
Y
A
Y
E
T
K
D
-
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
L
-
G
N
PG--
F
D
E
Q
R
A
V
F
Y
A
A
E
L
C
C
G
L
E
D
L
Q
R
E
-
R
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
R
G
H
I
R
I
S
D
L
G
L
A
T
E
-
I
P
E
G
Q
R
V
R
--
G
R
-
V
-
G
T
V
G
Y
M
A
P
E
V
V
N
---
N
E
-----
K
-----
Y
T
F
S
P
D
W
W
G
L
G
C
L
I
Y
E
M
I
Q
G
-
H
S
P
F
-----
K
K
Y
K
E
KVKW
E
---
E
V
D
Q
R
I
K
--
N
-----
D
T
E
E
Y
S
---
E
---
K
F
S
E
D
A
K
S
I
C
R
M
L
L
T
K
N
P
S
K
R
L
G
-
C
-
R
-
G
-
E
-
G
A
A
G
V
K
Q
H
P
V
F
K
D
I
N
---
F
R
R
L
E
A
N
M
L
E
-
P
P
F
C
P
D
-
P
------------------------------------------------------------------------
340
Blastp_CBE
48.26
38%
-58
- C2 -
-
4XW5
1
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
290
Blastp_CBE
48.28
39%
-54
- C2 -
-
2UVY
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
369
Blastp_CBE
48.24
38%
-59
- C2 -
-
1XH4
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
333
Blastp_CBE
48.25
38%
-59
- C2 -
-
3TNQ
1
KAPCA_MOUSE
B:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
356
Blastp_CBE
48.30
38%
-58
- C2 -
-
3X2U
1
KAPCA_MOUSE
A:
[41-337]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
347
Blastp_CBE
48.29
38%
-62
- C2 -
-
4IAK
1
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
375
Blastp_CBE
48.22
38%
-58
- C2 -
-
4C36
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
Y
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
167
Blastp_CBE
48.28
38%
-60
- C2 -
-
6MM8
6
KAPCA_MOUSE
C:
[23-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
349
Blastp_CBE
48.22
38%
-57
- C2 -
-
4IAF
1
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
540
Blastp_CBE
48.17
35%
-88
- C2 -
-
5LVP
1
PDPK1_HUMAN
A:
[33-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
G
---
L
I
F
A
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
426
Blastp_CBE
48.18
38%
-59
- C2 -
-
5N3F
3
KAPCA_CRIGR
A:
[34-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
--
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
--
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
94
Blastp_CBE
48.26
40%
-1
- C2 -
-
4L42
1
KS6B1_HUMAN
A:
[13-343]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
------
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
-------------------------------------------
E
M
---
F
R
D
F
E
Y
I
---------------------
296
Blastp_CBE
48.22
38%
-59
- C2 -
-
5N1D
3
KAPCA_CRIGR
A:
[35-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
140
Blastp_CBE
48.25
39%
-55
- C2 -
-
2VO0
4
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
176
Blastp_CBE
48.24
39%
-56
- C2 -
-
3DNE
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
313
Blastp_CBE
48.23
38%
-59
- C2 -
-
1RDQ
3
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
A
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
353
Blastp_CBE
48.16
38%
-58
- C2 -
-
4O21
1
KAPCA_MOUSE
A:
[26-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
262
Blastp_CBE
48.22
38%
-62
- C2 -
-
6E99
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
292
Blastp_CBE
48.15
38%
-57
- C2 -
-
5N7P
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
298
Blastp_CBE
48.17
38%
-60
- C2 -
-
5M75
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
367
Blastp_CBE
48.14
38%
-58
- C2 -
-
3KKV
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
185
Blastp_CBE
48.19
38%
-60
- C2 -
-
4UJA
2
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
170
Blastp_CBE
48.19
38%
-56
- C2 -
-
6MM6
1
KAPCA_MOUSE
E:
[23-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
271
Blastp_CBE
48.17
38%
-58
- C2 -
-
2GNF
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
217
Blastp_CBE
48.18
38%
-54
- C2 -
-
1ATP
1
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
147
Blastp_CBE
48.17
39%
-54
- C2 -
-
2JDT
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
320
Blastp_CBE
48.12
38%
-57
- C2 -
-
4DFX
5
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
105
Blastp_CBE
48.16
44%
10
- C2 -
-
4NW6
1
KS6A3_HUMAN
A:
[30-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
I--
S
-
G
S
-
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
-
D
R
V
R
-
T
K
M
E
R
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
--
S
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
A
-
G
-
P
-
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
-
P
P
F
K
P
------------
T
--
F
-----------------------------------------------------------
179
Blastp_CBE
48.15
38%
-60
- C2 -
-
1SMH
6
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
E
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
263
Blastp_CBE
48.14
38%
-61
- C2 -
-
4IE9
2
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
361
Blastp_CBE
48.13
38%
-59
- C2 -
-
3ZO2
4
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
396
Blastp_CBE
48.05
38%
-62
- C2 -
-
6EMB
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
519
Blastp_CBE
48.02
36%
-82
- C2 -
-
5HO8
1
PDPK1_HUMAN
A:
[31-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
156
Blastp_CBE
48.12
39%
-60
- C2 -
-
3L9N
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
----P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
294
Blastp_CBE
48.10
38%
-55
- C2 -
-
5N1K
3
KAPCA_CRIGR
A:
[35-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
--
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
579
Fugue
47.99
33%
0
- C2 -
-
1CDK
2
KAPCA_PIG
A:
[8-350]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
------
H
--
L
D
Q
--------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
----------------------------------------
G
--
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
G---
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
A
V
---
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
----S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-I
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q-
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
-
K
--
G
--
R
TW
T
L
-
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
SKG
Y
-------------
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y-
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
S------
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
---TTD
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
-
P
-
G
D
-
T
S
--
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
-------
N
E
K
C
G
-
K
E
---
F
S
E
F
------------------------
422
Blastp_CBE
48.01
38%
-55
- C2 -
-
5N3J
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
165
Blastp_CBE
48.09
38%
-62
- C2 -
-
1CDK
2
KAPCA_PIG
B:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
483
Blastp_CBE
47.98
39%
-30
- C2 -
-
3C4W
1
GRK1_BOVIN
B:
[192-479]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
---
M
---
K
-
A
T
-
G
--
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
------
K
V
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
-
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
-
D
E
DNPG
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
--
G
Y
-
A
-
G
T
P
G
F
M
A
P
E
L
L
L
---
G
E
-----
E
-----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
-
R
G
P
F
-----
R
A
R
G
E
KVEN
K
---
E
L
K
Q
R
V
L
--
E
-----
Q
A
V
T
Y
P
---
D
---
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
-
F
-
R
-
D
-
G
-
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
R
Q
L
E
A
G
M
L
T
-
P
P
F
V
P
---------------------------------------------------------------------------
264
Blastp_CBE
48.08
38%
-58
- C2 -
-
3ZO4
4
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
113
Blastp_CBE
48.07
41%
-3
- C2 -
-
3WF8
2
KS6B1_HUMAN
A:
[21-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
E
------
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
--------------------------------------------------------------------------
258
Blastp_CBE
48.05
38%
-57
- C2 -
-
1Q8T
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
197
Blastp_CBE
48.06
38%
-57
- C2 -
-
3AGM
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
214
Blastp_CBE
48.05
38%
-55
- C2 -
-
1RE8
2
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
429
Blastp_CBE
47.96
38%
-54
- C2 -
-
5N3C
2
KAPCA_CRIGR
A:
[36-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
260
Blastp_CBE
48.04
38%
-57
- C2 -
-
1Q24
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
322
Blastp_CBE
47.99
38%
-57
- C2 -
-
5JR7
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
397
Blastp_CBE
48.02
38%
-58
- C2 -
-
6EMA
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
289
Blastp_CBE
47.99
39%
-57
- C2 -
-
2UVZ
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
280
Blastp_CBE
47.99
39%
-54
- C2 -
-
2VO6
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
279
Blastp_CBE
47.99
38%
-58
- C2 -
-
3QAL
1
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
A
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
384
Blastp_CBE
47.94
38%
-59
- C2 -
-
5NW8
2
KAPCA_CRIGR
A:
[35-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
479
Blastp_CBE
47.90
39%
-28
- C2 -
-
3C50
1
GRK1_BOVIN
A:
[192-476]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
---
M
---
K
-
A
T
-
G
--
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
------
K
V
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
-
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
-
D
E
DNPG
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
--
G
Y
-
A
-
G
T
P
G
F
M
A
P
E
L
L
L
---
G
E
-----
E
-----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
-
R
G
P
F
-----
R
A
R
G
E
KVEN
K
---
E
L
K
Q
R
V
L
--
E
-----
Q
A
V
T
Y
P
---
D
---
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
-
F
-
R
-
D
-
G
-
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
R
Q
L
E
A
G
M
L
T
-
P
P
F
V
P
---------------------------------------------------------------------------
326
Blastp_CBE
48.00
38%
-56
- C2 -
-
4DH7
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
190
Blastp_CBE
47.99
38%
-58
- C2 -
-
3P0M
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
106
Blastp_CBE
47.99
44%
9
- C2 -
-
4NW5
1
KS6A3_HUMAN
A:
[30-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
I--
S
-
G
S
-
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
-
D
R
V
R
-
T
K
M
E
R
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
D
H
E
K
K
A
Y
--
S
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
A
-
G
-
P
-
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
-
P
P
F
K
P
------------
T
--
F
-----------------------------------------------------------
139
Blastp_CBE
47.98
39%
-60
- C2 -
-
1XH9
4
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
E
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
L
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
255
Blastp_CBE
47.96
38%
-57
- C2 -
-
1SVE
2
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
141
Blastp_CBE
47.97
39%
-62
- C2 -
-
2QUR
1
KAPCA_MOUSE
A:
[34-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
P
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
----------------------------------------------------------------------
237
Blastp_CBE
47.96
38%
-58
- C2 -
-
1XH5
3
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
210
Blastp_CBE
47.94
38%
-57
- C2 -
-
3IDB
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
112
Blastp_CBE
47.94
41%
-6
- C2 -
-
3WF9
2
KS6B1_HUMAN
A:
[21-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
E
------
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
--------------------------------------------------------------------------
307
Blastp_CBE
47.93
38%
-58
- C2 -
-
5LCT
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
284
Blastp_CBE
47.90
39%
-57
- C2 -
-
2UW8
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
522
Blastp_CBE
47.82
36%
-83
- C2 -
-
5HKM
1
PDPK1_HUMAN
A:
[31-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
----------
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
389
Blastp_CBE
47.92
38%
-62
- C2 -
-
6I2A
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
327
Blastp_CBE
47.91
38%
-56
- C2 -
-
4DH5
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
187
Blastp_CBE
47.90
38%
-59
- C2 -
-
4UJ2
2
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
199
Blastp_CBE
47.89
38%
-58
- C2 -
-
5BX6
4
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
442
Blastp_CBE
47.87
38%
-56
- C2 -
-
5N1F
3
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
408
Blastp_CBE
47.85
38%
-53
- C2 -
-
5OL3
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
332
Blastp_CBE
47.84
38%
-58
- C2 -
-
2QCS
5
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
398
Blastp_CBE
47.76
38%
-59
- C2 -
-
6EM6
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
463
Blastp_CBE
47.73
39%
-33
- C2 -
-
4L9I
1
GRK1_BOVIN
A:
[163-442]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
---
M
---
K
-
A
T
-
G
--
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
------
K
V
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
-
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
-
D
E
DNPG
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
--
G
Y
-
A
-
G
T
P
G
F
M
A
P
E
L
L
L
---
G
E
-----
E
-----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
-
R
G
P
F
-----
R
A
R
G
E
KVEN
K
---
E
L
K
Q
R
V
L
--
E
-----
Q
A
V
T
Y
P
---
D
---
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
-
F
-
R
-
D
-
G
-
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
R
Q
L
E
A
G
M
L
T
-
P
P
F
V
P
---------------------------------------------------------------------------
335
Blastp_CBE
47.82
38%
-54
- C2 -
-
3PVB
1
KAPCA_MOUSE
A:
[29-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
216
Blastp_CBE
47.81
38%
-57
- C2 -
-
1FMO
1
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
331
Blastp_CBE
47.80
38%
-57
- C2 -
-
4DG0
2
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
329
Blastp_CBE
47.74
38%
-58
- C2 -
-
4DH1
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
458
Blastp_CBE
47.69
39%
-23
- C2 -
-
4TND
1
GRK5_HUMAN
A:
[186-469]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
---
V
---
R
-
A
T
-
G
--
K
M
Y
A
C
K
R
L
E
K
K
R
I
K
K
R
-
K
G
E
S
M
A
L
N
E
K
Q
I
-
L
E
------
K
V
N
S
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
-
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
-
G
N
PG--
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
-
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
-
I
P
E
G
D
L
I
R
--
G
R
-
V
-
G
T
V
G
Y
M
A
P
E
V
L
N
---
N
Q
-----
R
-----
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
-
Q
S
P
F
-----
R
G
R
K
E
KVKR
E
---
E
V
D
R
R
V
L
--
E
-----
T
E
E
V
Y
S
---
H
---
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
-
C
-
Q
-
E
-
E
-
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
---
F
K
R
L
E
A
G
M
L
D
-
P
P
F
V
P
D
-
P
------------------------------------------------------------------------
318
Blastp_CBE
47.69
38%
-56
- C2 -
-
4X6R
5
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
274
Blastp_CBE
47.76
38%
-58
- C2 -
-
2GNH
2
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
324
Blastp_CBE
47.73
38%
-59
- C2 -
-
4HPU
2
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
427
Blastp_CBE
47.60
38%
-59
- C2 -
-
5N3E
3
KAPCA_CRIGR
A:
[36-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
225
Blastp_CBE
47.76
38%
-55
- C2 -
-
2ERZ
1
KAPCA_MOUSE
E:
[35-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
406
Blastp_CBE
47.68
38%
-61
- C2 -
-
5OTG
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
441
Blastp_CBE
47.75
38%
-53
- C2 -
-
5N1G
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
300
Blastp_CBE
47.71
38%
-55
- C2 -
-
5M6Y
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
287
Blastp_CBE
47.74
39%
-55
- C2 -
-
2UW3
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
283
Blastp_CBE
47.71
39%
-56
- C2 -
-
2VNW
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
308
Blastp_CBE
47.73
38%
-56
- C2 -
-
5LCR
6
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
155
Blastp_CBE
47.72
39%
-59
- C2 -
-
1YDR
1
KAPCA_BOVIN
E:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
206
Blastp_CBE
47.71
38%
-55
- C2 -
-
4DIN
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
256
Blastp_CBE
47.70
38%
-63
- C2 -
-
1STC
1
KAPCA_BOVIN
E:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
143
Blastp_CBE
47.69
39%
-55
- C2 -
-
2UW7
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
341
Blastp_CBE
47.63
38%
-55
- C2 -
-
4XW4
1
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
317
Blastp_CBE
47.68
38%
-59
- C2 -
-
4WB5
1
KAPCA_HUMAN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
314
Blastp_CBE
47.63
38%
-58
- C2 -
-
4WB8
2
KAPCA_HUMAN
A:
[26-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
164
Blastp_CBE
47.67
38%
-53
- C2 -
-
1JBP
2
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
E
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
394
Blastp_CBE
47.58
38%
-54
- C2 -
-
6ERS
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
--
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
480
Blastp_CBE
47.65
39%
-32
- C2 -
-
3C4Z
1
GRK1_BOVIN
A:
[192-478]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
G
R
G
G
F
G
E
V
F
A
C
Q
---
M
---
K
-
A
T
-
G
--
K
L
Y
A
C
K
K
L
N
K
K
R
L
K
K
R
-
K
G
Y
Q
G
A
M
V
E
K
K
I
-
L
A
------
K
V
H
S
R
F
I
V
S
L
A
Y
A
F
E
T
K
T
-
D
L
C
L
V
M
T
I
M
N
G
G
D
I
R
Y
H
I
Y
N
V
-
D
E
DNPG
F
Q
E
P
R
A
I
F
Y
T
A
Q
I
V
S
G
L
E
H
L
H
Q
R
-
N
I
I
Y
R
D
L
K
P
E
N
V
L
L
D
-
D
D
G
N
V
R
I
S
D
L
G
L
A
V
E
L
K
A
G
Q
T
K
T
K
--
G
Y
-
A
-
G
T
P
G
F
M
A
P
E
L
L
L
---
G
E
-----
E
-----
Y
D
F
S
V
D
Y
F
A
L
G
V
T
L
Y
E
M
I
A
A
-
R
G
P
F
-----
R
A
R
G
E
KVEN
K
---
E
L
K
Q
R
V
L
--
E
-----
Q
A
V
T
Y
P
---
D
---
K
F
S
P
A
S
K
D
F
C
E
A
L
L
Q
K
D
P
E
K
R
L
G
-
F
-
R
-
D
-
G
-
S
C
D
G
L
R
T
H
P
L
F
R
D
I
S
---
W
R
Q
L
E
A
G
M
L
T
-
P
P
F
V
P
---------------------------------------------------------------------------
404
Blastp_CBE
47.57
38%
-61
- C2 -
-
5OUC
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
145
Blastp_CBE
47.64
39%
-57
- C2 -
-
2UVX
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
192
Blastp_CBE
47.63
38%
-53
- C2 -
-
3OWP
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
158
Blastp_CBE
47.63
39%
-56
- C2 -
-
3L9M
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
344
Blastp_CBE
47.57
38%
-55
- C2 -
-
4IB0
1
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
213
Blastp_CBE
47.62
38%
-56
- C2 -
-
1REJ
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
212
Blastp_CBE
47.62
38%
-55
- C2 -
-
1REK
2
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
299
Blastp_CBE
47.61
38%
-59
- C2 -
-
5M71
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
400
Blastp_CBE
47.60
38%
-61
- C2 -
-
6EH3
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
386
Blastp_CBE
47.52
38%
-51
- C2 -
-
6I2D
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
417
Blastp_CBE
47.59
38%
-55
- C2 -
-
5N3P
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
205
Blastp_CBE
47.58
38%
-56
- C2 -
-
4HPT
1
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
272
Blastp_CBE
47.56
38%
-56
- C2 -
-
3QAM
1
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
A
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
433
Blastp_CBE
47.48
38%
-58
- C2 -
-
5N37
6
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
338
Blastp_CBE
47.57
38%
-54
- C2 -
-
6E21
1
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
175
Blastp_CBE
47.56
39%
-56
- C2 -
-
4YXR
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
285
Blastp_CBE
47.50
39%
-58
- C2 -
-
2UW6
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
350
Blastp_CBE
47.46
38%
-58
- C2 -
-
4IAD
1
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
387
Blastp_CBE
47.43
38%
-54
- C2 -
-
6I2C
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
--
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
118
Blastp_CBE
47.50
42%
-6
- C2 -
-
4L3L
1
KS6B1_HUMAN
A:
[20-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
-
L
------
E
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
---------------------------------------------------------------------------
440
Blastp_CBE
47.40
38%
-55
- C2 -
-
5N1H
3
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
409
Blastp_CBE
47.41
38%
-59
- C2 -
-
5OK3
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
261
Blastp_CBE
47.48
38%
-55
- C2 -
-
6E9L
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
381
Blastp_CBE
47.41
39%
-55
- C2 -
-
4WB7
1
DNJB1_HUMAN (first)
A:
[94-385]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
191
Blastp_CBE
47.46
38%
-58
- C2 -
-
3OXT
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
355
Blastp_CBE
47.45
38%
-56
- C2 -
-
3X2V
1
KAPCA_MOUSE
A:
[41-337]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
348
Blastp_CBE
47.43
38%
-56
- C2 -
-
4IAI
2
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
418
Blastp_CBE
47.34
38%
-53
- C2 -
-
5N3O
6
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
168
Blastp_CBE
47.42
38%
-52
- C2 -
-
6MM7
9
KAPCA_MOUSE
D:
[23-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
116
Blastp_CBE
47.41
41%
-5
- C2 -
-
3WF5
1
KS6B1_HUMAN
A:
[21-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
R
N
I
-
L
E
------
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
-
L
Q
-----------------------------------------------------------------------
425
Blastp_CBE
47.40
38%
-54
- C2 -
-
5N3G
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
178
Blastp_CBE
47.39
38%
-55
- C2 -
-
1XHA
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
E
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
L
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
278
Blastp_CBE
47.38
38%
-61
- C2 -
-
6F14
2
KAPCA_CRIGR
A:
[35-331]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
----
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
224
Blastp_CBE
47.37
38%
-57
- C2 -
-
1BKX
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
166
Blastp_CBE
47.37
38%
-59
- C2 -
-
1CDK
2
KAPCA_PIG
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
F
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
D
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
539
Blastp_CBE
47.25
35%
-78
- C2 -
-
5LVP
1
PDPK1_HUMAN
B:
[33-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
---------
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
G
---
L
I
F
A
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
157
Blastp_CBE
47.35
39%
-56
- C2 -
-
3L9M
1
KAPCA_HUMAN
B:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
-
Q
Q
G
Y
I
K
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
334
Blastp_CBE
47.29
38%
-58
- C2 -
-
1L3R
3
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
195
Blastp_CBE
47.34
38%
-55
- C2 -
-
3L9L
1
KAPCA_HUMAN
B:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
303
Blastp_CBE
47.29
38%
-53
- C2 -
-
5M0L
3
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
302
Blastp_CBE
47.29
38%
-58
- C2 -
-
5M0U
10
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
----
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
354
Blastp_CBE
47.26
38%
-56
- C2 -
-
3X2W
1
KAPCA_MOUSE
A:
[41-337]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
342
Blastp_CBE
47.26
38%
-55
- C2 -
-
4IB3
1
KAPCA_MOUSE
A:
[40-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
211
Blastp_CBE
47.31
38%
-57
- C2 -
-
3FJQ
1
KAPCA_MOUSE
E:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
196
Blastp_CBE
47.29
38%
-52
- C2 -
-
3L9L
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
395
Blastp_CBE
47.20
38%
-50
- C2 -
-
6EMD
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
223
Blastp_CBE
47.26
38%
-57
- C2 -
-
1BX6
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
194
Blastp_CBE
47.26
38%
-57
- C2 -
-
3OOG
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
189
Blastp_CBE
47.25
38%
-51
- C2 -
-
3POO
2
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
-----
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
399
Blastp_CBE
47.23
38%
-57
- C2 -
-
6EM2
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
416
Blastp_CBE
47.22
38%
-55
- C2 -
-
5N3Q
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
424
Blastp_CBE
47.21
38%
-54
- C2 -
-
5N3H
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
227
Blastp_CBE
47.20
38%
-56
- C2 -
-
3O7L
2
KAPCA_MOUSE
B:
[34-334]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
---
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
I
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
I
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
115
Blastp_CBE
47.20
41%
-5
- C2 -
-
3WF6
1
KS6B1_HUMAN
A:
[21-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
------------
T
K
A
E
R
N
I
-
L
E
------
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
H
D
G
T
V
T
H
--
T
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
-
L
Q
-----------------------------------------------------------------------
414
Blastp_CBE
47.13
38%
-54
- C2 -
-
5N3S
5
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
202
Blastp_CBE
47.11
38%
-52
- C2 -
-
3AGL
1
KAPCA_HUMAN
B:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
410
Blastp_CBE
47.09
38%
-49
- C2 -
-
5O5M
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
---
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
411
Blastp_CBE
47.08
38%
-58
- C2 -
-
5O0E
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
443
Blastp_CBE
47.06
38%
-55
* C2 *
-
6FRX
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
------
Q
Q
A
V
N
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
-------
N
--
F
D
D
Y
--------------------------------------------------------
420
Blastp_CBE
46.97
38%
-54
- C2 -
-
5N3L
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
312
Blastp_CBE
47.05
38%
-56
- C2 -
-
3FHI
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
A
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
388
Blastp_CBE
46.95
38%
-46
- C2 -
-
6I2B
2
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
---
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
104
Blastp_CBE
47.01
44%
4
- C2 -
-
5D9L
2
KS6A3_HUMAN
A:
[30-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
I--
S
-
G
S
-
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
-
D
R
V
R
-
T
K
M
E
R
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
A
-
G
-
P
-
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
-
P
P
F
K
P
--
A
T
G
-
R
-
P
E
-
D
T
--
F
-----------------------------------------------------------
325
Blastp_CBE
47.00
38%
-57
- C2 -
-
4DH8
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
370
Blastp_CBE
46.97
38%
-58
- C2 -
-
1Q8W
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
323
Blastp_CBE
46.96
38%
-55
- C2 -
-
4WBB
1
KAPCA_MOUSE
B:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
383
Blastp_CBE
46.95
38%
-53
- C2 -
-
6EM7
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
110
Blastp_CBE
46.94
44%
-15
- C2 -
-
3UBD
1
KS6A3_MOUSE
A:
[24-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
I--
S
-
G
S
-
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
-
D
R
V
-------
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-----
E
K
K
A
Y
--
S
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
A
-
G
-
P
-
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
-
P
P
F
K
P
---------------------------------------------------------------------------
207
Blastp_CBE
46.91
38%
-58
- C2 -
-
3OW3
1
KAPCA_MOUSE
A:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
235
Blastp_CBE
46.87
38%
-56
- C2 -
-
1XH8
1
KAPCA_BOVIN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
103
Blastp_CBE
46.86
44%
-4
- C2 -
-
5D9K
2
KS6A3_HUMAN
A:
[30-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
I--
S
-
G
S
-
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
-
D
R
V
R
-
T
K
M
E
R
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
---------------
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
A
-
G
-
P
-
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
-
P
P
F
K
P
--
A
---------
T
FY
F
D
P
---------------------------------------------------------
358
Blastp_CBE
46.85
38%
-54
- C2 -
-
3AMB
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
------
Q
Q
A
V
N
F
P
-
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
K
V
A
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
-------
N
--
F
D
D
Y
--------------------------------------------------------
390
Blastp_CBE
46.84
38%
-53
- C2 -
-
6ESA
4
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
203
Blastp_CBE
46.83
38%
-57
- C2 -
-
3AGL
1
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
357
Blastp_CBE
46.77
38%
-58
- C2 -
-
3NX8
3
KAPCA_HUMAN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
N
L
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
270
Blastp_CBE
46.72
38%
-57
- C2 -
-
4WB6
1
KAPCA_HUMAN
B:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
R
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
362
Blastp_CBE
46.71
38%
-53
- C2 -
-
5VHB
1
KAPCA_BOVIN
A:
[40-331]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
------
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
371
Blastp_CBE
46.70
38%
-57
- C2 -
-
4WB6
1
KAPCA_HUMAN
A:
[39-330]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
R
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
402
Blastp_CBE
46.67
38%
-52
- C2 -
-
6EGW
1
KAPCA_CRIGR
A:
[37-333]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
------
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P--
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
459
Blastp_CBE
46.65
39%
-20
- C2 -
-
4TNB
1
GRK5_HUMAN
A:
[186-469]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
R
Q
Y
R
V
L
G
K
G
G
F
G
E
V
C
A
C
Q
---
V
---
R
-
A
T
-
G
--
K
M
Y
A
C
K
R
L
E
K
K
R
I
K
K
R
-
K
G
E
S
M
A
L
N
E
K
Q
I
-
L
E
------
K
V
N
S
Q
F
V
V
N
L
A
Y
A
Y
E
T
K
D
-
A
L
C
L
V
L
T
I
M
N
G
G
D
L
K
F
H
I
Y
N
M
-
G
N
PG--
F
E
E
E
R
A
L
F
Y
A
A
E
I
L
C
G
L
E
D
L
H
H
E
-
N
T
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
D
Y
G
H
I
R
I
S
D
L
G
L
A
V
K
-
I
P
E
G
D
L
I
R
--
G
R
-
V
-
G
T
V
G
Y
M
A
P
E
V
L
N
---
N
Q
-----
R
-----
Y
G
L
S
P
D
Y
W
G
L
G
C
L
I
Y
E
M
I
E
G
-
Q
S
P
F
-----
R
G
R
K
E
KVKR
E
---
E
V
D
R
R
V
L
--
E
-----
T
E
E
V
Y
S
---
H
---
K
F
S
E
E
A
K
S
I
C
K
M
L
L
T
K
D
A
K
Q
R
L
G
-
C
-
Q
-
E
-
E
-
E
A
A
E
V
K
R
H
P
F
F
R
N
M
N
---
F
K
R
L
E
A
G
M
L
D
-
P
P
F
V
P
D
-
P
------------------------------------------------------------------------
109
Blastp_CBE
46.50
44%
-7
- C2 -
-
4EL9
1
KS6A3_MOUSE
A:
[25-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
I--
S
-
G
S
-
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
-
D
R
V
------
R
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
---
E
K
K
A
Y
--
S
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
A
-
G
-
P
-
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
-
P
P
F
K
P
---------------------------------------------------------------------------
111
Blastp_CBE
46.41
40%
-14
- C2 -
-
3A62
1
KS6B1_HUMAN
A:
[13-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
--------------
K
A
E
R
N
I
-
L
E
------
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
------------
F
-
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
--------------------------------------------------------------------------
321
Blastp_CBE
46.33
38%
-55
- C2 -
-
5JR7
1
KAPCA_MOUSE
C:
[34-330]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
S
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
------
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
265
Blastp_CBE
46.31
38%
-51
- C2 -
-
3AG9
1
KAPCA_BOVIN
B:
[40-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
230
Blastp_CBE
46.26
38%
-50
- C2 -
-
3MVJ
1
KAPCA_HUMAN
E:
[60-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
108
Blastp_CBE
46.26
44%
-13
- C2 -
-
4GUE
1
KS6A3_MOUSE
A:
[25-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
I--
S
-
G
S
-
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
-
D
R
V
----------
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
-----
E
K
K
A
Y
--
S
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
A
-
G
-
P
-
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
-
P
P
F
K
P
---------------------------------------------------------------------------
380
Blastp_CBE
46.19
39%
-52
- C2 -
-
4WB7
1
KAPCA_HUMAN
B:
[94-385]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
-
A
V
N
F
P
-----
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
102
Blastp_CBE
46.12
44%
5
- C2 -
-
5D9K
2
KS6A3_HUMAN
B:
[30-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
I--
S
-
G
S
-
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
R
-
D
R
V
R
-
T
K
M
E
R
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
--------------
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
A
-
G
-
P
-
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
-
P
P
F
K
P
------------
T
FY
F
D
P
---------------------------------------------------------
89
Blastp_CBE
45.91
45%
-44
- C2 -
-
4CRS
1
A:
[8-337]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
F
N
L
Q
D
F
R
C
C
A
V
L
L
R
G
H
F
G
K
V
L
L
A
E
---
Y
---
K
-
N
T
-
N
--
E
M
F
A
I
K
A
L
K
K
G
D
I
V
A
R
-
D
E
V
D
S
L
M
C
E
K
R
I
-
F
E
T
V
N
---
S
V
R
H
P
F
L
V
N
L
F
A
C
F
Q
T
K
E
-
H
V
C
F
V
M
E
Y
A
A
G
G
D
L
M
M
H
I
H
T
---
D
----
V
F
E
P
R
A
V
F
Y
A
A
C
V
V
L
G
L
Q
Y
L
H
E
H
-
K
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
-
T
E
G
F
V
K
I
A
D
F
G
L
C
K
E
G
M
G
Y
G
D
R
T
---
S
F
-
C
-
G
T
P
E
F
L
A
P
E
V
L
T
---
E
T
-----
S
-----
Y
T
R
A
V
D
W
W
G
L
G
V
L
I
Y
E
M
L
V
G
-
E
S
P
F
-----
P
G
D
D
E
----
E
---
E
V
F
D
S
I
V
--
N
-----
D
E
V
R
Y
P
---
R
---
F
L
S
T
E
A
I
S
I
M
R
R
L
L
R
R
N
P
E
R
R
L
G
-
A
-
S
-
E
-
K
-
D
A
E
D
V
K
K
H
P
F
F
R
L
I
D
---
W
S
A
L
M
D
K
K
V
K
-
P
P
F
I
P
T
-
I
R
G
-
R
-
E
D
V
S
N
--
F
D
D
E
F
T
S
E
A
P
I
L
P
P
R
E
P
R
-
I
L
S
-----------
R
D
F
D
Y
I
---------------------
456
Blastp_CBE
45.87
35%
-28
- C2 -
-
6BDL
1
KGP1_HUMAN
A:
[29-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
L
K
L
S
D
F
N
I
I
D
T
L
G
V
G
G
F
G
R
V
E
L
V
Q
---
L
---
K
-
S
E
-
E
S-
K
T
F
A
M
K
I
L
K
K
R
H
I
V
D
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
-
M
Q
------
G
A
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
-
G
S
----
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
K
-
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
K
I
G
F
G
K
K
T
----
W
F
-
C
-
G
T
P
E
Y
V
A
P
E
I
I
L
---
N
K
-----
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
G
P
D
P
----
M
---
K
T
Y
N
I
I
L
--
R
GI---
D
M
I
E
F
P
---
K
---
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
R
L
G
-
N
-
L
-
K
-
N
-
G
V
K
D
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
-
P
P
I
I
P
S
-
V
A
S
P
T
-
D
T
-
S
N
--
F
D
S
F
--------------------------------------------------------
401
Blastp_CBE
45.77
38%
-57
- C2 -
-
6EH2
2
KAPCA_CRIGR
A:
[37-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
N
T
A
Q
L
D
H
F
D
R
I
K
T
L
---
S
F
G
R
V
M
L
V
K
---
H
---
K
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
---
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
455
Blastp_CBE
45.61
35%
-27
- C2 -
-
6BDL
1
KGP1_HUMAN
B:
[29-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
L
K
L
S
D
F
N
I
I
D
T
L
G
V
G
G
F
G
R
V
E
L
V
Q
---
L
---
K
-
S
E
-
E
S-
K
T
F
A
M
K
I
L
K
K
R
H
I
V
D
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
-
M
Q
------
G
A
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
-
G
S
----
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
K
-
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
K
I
G
F
G
K
K
T
----
W
F
-
C
-
G
T
P
E
Y
V
A
P
E
I
I
L
---
N
K
-----
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
G
P
D
P
----
M
---
K
T
Y
N
I
I
L
--
R
GI---
D
M
I
E
F
P
---
K
---
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
R
L
G
-
N
-
L
-
K
-
N
-
G
V
K
D
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
-
P
P
I
I
P
S
-
V
A
S
P
T
-
D
T
-
S
N
--
F
D
S
F
--------------------------------------------------------
450
Blastp_CBE
45.52
35%
-22
- C2 -
-
6C0T
3
KGP1_HUMAN
A:
[29-328]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
N
L
K
L
S
D
F
N
I
I
D
T
L
G
V
G
G
F
G
R
V
E
L
V
Q
---
L
---
K
-
S
E
-
E
S-
K
T
F
A
M
K
I
L
K
K
R
H
I
V
D
T
-
R
Q
Q
E
H
I
R
S
E
K
Q
I
-
M
Q
------
G
A
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
R
-
G
S
----
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
K
-
G
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
-
H
R
G
Y
A
K
L
V
D
F
G
F
A
K
K
I
G
F
G
K
K
T
----
W
F
-
C
-
G
T
P
E
Y
V
A
P
E
I
I
L
---
N
K
-----
G
-----
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
-
S
P
P
F
-----
S
G
P
D
P
----
M
---
K
T
Y
N
I
I
L
--
R
GI---
D
M
I
E
F
P
---
K
---
K
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
R
L
G
-
N
-
L
-
K
-
N
-
G
V
K
D
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
-
P
P
I
I
P
S
-
V
A
S
P
T
-
D
T
-
S
N
--
F
D
S
F
--------------------------------------------------------
485
Blastp_CBE
45.11
35%
-51
- C2 -
-
1UVR
8
PDPK1_HUMAN
A:
[3-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----
A
R
A-
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
101
Blastp_CBE
45.02
44%
-9
- C2 -
-
3G51
1
KS6A3_MOUSE
A:
[24-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
K
---
K
I--
S
-
G
S
-
D
AR
Q
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-----------
R
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
S
I
---------------
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
A
-
G
-
P
-
D
-
G
V
E
E
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
-
P
P
F
K
P
---------------------------------------------------------------------------
100
Blastp_CBE
44.85
45%
-11
- C2 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[28-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
KVT
R
---
P
-
D
S
-
G
--
H
L
Y
A
M
K
V
L
--------------------
I
-
L
A
-----
D
V
N
H
P
-
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
Q
-----
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
L
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
-
S
-
G
-
P
-
D
-
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
-
P
P
F
K
P
---------------------------------------------------------------------------
550
Blastp_CBE
44.80
35%
-54
- C2 -
-
4A06
3
PDPK1_HUMAN
A:
[33-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
E
S
K
Q
A
R
A-
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
G
---
L
I
F
A
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
98
Blastp_CBE
44.68
45%
-9
- C2 -
-
2Z7S
1
KS6A1_HUMAN
A:
[28-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
KVT
R
---
P
-
D
S
-
G
--
H
L
Y
A
M
K
V
L
K
-------------------
I
-
L
A
-----
D
V
N
H
P
-
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
Q
-----
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
L
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
-
S
-
G
-
P
-
D
-
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
-
P
P
F
K
P
---------------------------------------------------------------------------
132
Blastp_CBE
44.58
41%
-10
- C2 -
-
6G78
1
KS6A6_HUMAN
A:
[29-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
---
K
---
K
T
G
P
-
D
AG
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
V
R
-
D
---------
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
D
Q
------------
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
N
---
E
T
M
N
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
S
-----
E
-
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
-
P
P
F
K
P
---------------------------------------------------------------------------
130
Blastp_CBE
44.49
41%
-5
- C2 -
-
6G77
2
KS6A6_HUMAN
A:
[29-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
---
K
---
K
T
G
P
-
D
AG
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
V
R
-
D
---------
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
D
Q
E
K
K
A
Y
--
S
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
N
---
E
T
M
N
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
S
-----
E
-
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
-
P
P
F
K
P
---------------------------------------------------------------------------
129
Blastp_CBE
44.36
41%
1
- C2 -
-
6G77
2
KS6A6_HUMAN
B:
[29-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
---
K
---
K
T
G
P
-
D
AG
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
V
R
-
D
---------
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
D
Q
E
K
K
A
Y
--
S
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
N
---
E
T
M
N
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
S
-----
E
-
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
-
P
P
F
K
P
---------------------------------------------------------------------------
515
Blastp_CBE
44.34
36%
-52
- C2 -
-
3RWQ
4
PDPK1_HUMAN
A:
[33-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----
A
R
A-
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
486
Blastp_CBE
44.33
35%
-48
- C2 -
-
1H1W
9
PDPK1_HUMAN
A:
[3-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
P
R
K
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
S
F
S
T
V
V
L
A
R
---
E
---
L
-
A
T
-
S
--
R
E
Y
A
I
K
I
L
E
K
R
H
I
I
K
E
-
N
K
V
P
Y
V
T
R
E
R
D
V
-
M
S
R
L
D
H
P
------
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
I
-
G
S
----
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
K
-
G
I
I
H
R
D
L
K
P
E
N
I
L
L
N
-
E
D
M
H
I
Q
I
T
D
F
G
T
A
K
V
L
S
P
----
A
R
A-
N
F
-
V
-
G
T
A
Q
Y
V
S
P
E
L
L
T
---
E
K
-----
S
-----
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
-
L
P
P
F
-----
R
A
G
N
E
----
Y
---
L
I
F
Q
K
I
I
--
K
-----
L
E
Y
D
F
P
---
E
---
K
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
L
G
C
E
-
E
-
M
-
E
-
G
Y
G
P
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
-
Q
T
P
-
P
-------------------------------------------------------------------------------
131
Blastp_CBE
43.95
41%
-10
- C2 -
-
6G78
1
KS6A6_HUMAN
B:
[29-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
---
K
---
K
T
G
P
-
D
AG
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
V
R
-
D
---------
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
--------------
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
N
---
E
T
M
N
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
S
-----
E
-
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
-
P
P
F
K
P
---------------------------------------------------------------------------
99
Blastp_CBE
43.51
45%
1
- C2 -
-
2Z7R
1
KS6A1_HUMAN
A:
[28-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
KVT
R
---
P
-
D
S
-
G
--
H
L
Y
A
M
K
V
L
K
K
A
T
L
K
V
-------------
I
-
L
A
-----
D
V
N
H
P
-
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
-
V
M
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
E
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
Q
-----
G
-----
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
S
L
P
F
-----
Q
G
K
D
R
----
K
---
E
T
M
T
L
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
L
G
-
S
-
G
-
P
-
D
-
G
A
E
E
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
-
P
P
F
K
P
---------------------------------------------------------------------------
95
Blastp_CBE
42.97
40%
-8
- C2 -
-
3A61
1
KS6B1_HUMAN
A:
[15-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
---------------
K
A
E
R
N
I
-
L
E
------
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
--------------------
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
---------------------------------------------------------------------------
96
Blastp_CBE
41.51
40%
1
- C2 -
-
3A60
1
KS6B1_HUMAN
B:
[13-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
------------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
-------------
C
-
G
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
L
--------------------------------------------------------------------------
97
Blastp_CBE
41.47
40%
-8
- C2 -
-
3A60
1
KS6B1_HUMAN
A:
[13-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
P
E
C
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
A
M
-----------
K
A
E
R
N
I
-
L
E
------
E
V
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
-----------------
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
---------------------------------------------------------------------------
162
Blastp_CBE
41.17
41%
-14
- C2 -
-
6G76
1
KS6A6_HUMAN
B:
[29-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
---
K
---
K
T
G
P
-
D
AG
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
V
-----------
R
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
---
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
-
D
--------------
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
N
---
E
T
---------------
L
G
M
P
---
Q
---
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
S
-----
E
-
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
-
P
P
F
K
P
---------------------------------------------------------------------------
163
Blastp_CBE
41.07
41%
-24
- C2 -
-
6G76
2
KS6A6_HUMAN
A:
[29-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
L
V
R
---
K
---
K
T
G
P
-
D
AG
Q
L
Y
A
M
K
V
L
K
K
A
S
L
K
V
R
-
D
---------
D
I
-
L
V
-----
E
V
N
H
P
-
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
-
V
L
----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
L
-
G
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
-
E
I
G
H
I
K
L
T
D
F
G
L
S
K
E
S
V
-
D
Q
E
K
K
A
--
Y
F
-
C
-
G
T
V
E
Y
M
A
P
E
V
V
N
---
R
R
-----
G
-----
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
-
T
L
P
F
-----
Q
G
K
D
R
----
N
---
E
T
M
N
M
I
L
--
K
-----
A
K
L
G
M
P
---
Q
---
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
-
S
-----
E
-
G
V
E
E
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
-
P
P
F
K
P
---------------------------------------------------------------------------
121
Blastp_CBE
39.63
42%
4
- C2 -
-
4RLO
4
KS6B1_HUMAN
B:
[7-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
L
L
R
V
L
G
K
G
G
Y
G
K
V
F
Q
V
R
---
K
VTG
A
-
N
T
-
G
--
K
I
F
A
M
K
V
L
K
K
------------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
E
-
G
I
----
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
K
-
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
-
H
Q
G
H
V
K
L
T
D
F
G
L
C
K
E
S
I
---------------
T
I
E
Y
M
A
P
E
I
L
M
---
R
S
-----
G
-----
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
-
A
P
P
F
-----
T
G
E
N
R
----
K
---
K
T
I
D
K
I
L
--
K
-----
C
K
L
N
L
P
---
P
---
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
L
G
-
A
-
G
-
P
-
G
-
D
A
G
E
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
-
P
P
F
K
P
---------------------------------------------------------------------------
240
Blastp_CBE
28.14
38%
13
- C2 -
-
5VI9
1
KAPCA_BOVIN
A:
[15-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
---
H
---
M
-
E
T
-
G
--
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
K
L
-
K
Q
I
E
H
T
L
N
E
K
R
I
-
L
Q
------
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
-
G
R
----
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
-
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
-
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-----
V
K
G
R
--
T
W
L
C
-
G
T
P
E
Y
L
A
P
E
I
I
L
---
S
K
-----
G
-----
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-
Y
P
P
F
-----
F
A
D
Q
P
----
I
---
Q
I
Y
E
K
I
V
--
S
-----
G
K
V
R
F
P
---
S
---
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
-
N
-
L
-
K
-
N
-
G
V
N
D
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
-
A
P
F
I
P
K
-
F
K
G
P
G
-
D
T
-
S
N
--
F
D
D
Y
--------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------