@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : KSR2_HUMAN: (2020-09-13 )
MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
Atome Classification :
(138 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.-..-....800........810.......820.......830.......840.......850.......860.......870..-.-.-...880...-....-890-....--..------..900.........910.......920.......----930.......940.......950
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDEENMTKSEEQQ
P
L
S
L
Q
K
A
L
Q
Q
C
E
L
V
Q
N
M
I
D
L
SIS
N
L
E
G
L
R
T
KCATSND
L
T
Q
K
E
I
R
T
L
E
S
K
L
V
K
Y
F
S
R
Q
LSC
K
K
K
V
A
L
Q
ERNAELDG
F
P
Q
L
R
H
W
F
R
I
V
D
V
R
K
E
V
L
E
EISPGQL
S
L
E
D
L
L
E
M
T
D
E
Q
V
C
E
T
V
E
K
YGA
N
R
E
E
C
A
R
L
N
A
S
L
S
C
L
R
N
V
HMSGGNLSKQ
D
W
T
I
QWPTTETGKENNPVCPPEP
T
P
W
I
R
T
HLSQSPRV
P
S
K
C
V
Q
H
Y
CHTSPTPGAP
V
Y
T
H
V
D
R
L
T
VDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTP
N
I
V
T
TVTPPGTPPMRKKNKLKPPGTPPPSS
R
K
L
I
H
LIP
G
F
T
A
L
HRSKSHEFQLGHRVDEAHTPKAKKKSK
P
L
N
L
K
I
HSSVGSCENI
P
S
Q
Q
RSP
L
L
S
E
R
S
L
R
S
F
F
VGHAPFLPSTPPVHTEANFSANTLSVPRWSPQI
P
R
R
D
L
G
N
S
I
K
H
R
F
ST
K
Y
W
M
S
Q
T
C
T
VCGKG
M
L
F
G
L
K
CKN
C
K
L
K
CHNKCTKEAPP
C
H
L
L
I
I
HRGDP
A
R
L
V
RTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSP
Q
C
T
R
QQKNFNL
P
A
S
H
Y
Y
K
Y
K
Q
Q
FIFPDVVPVPETPTRA
P
Q
V
I
L
H
PVTSNPILEGN
P
L
L
Q
I
E
VEPTSEN
E
E
VHDEAEESE
D
D
F
E
E
M
N
L
S
L
L
SARSFPRKASQ
T
S
I
F
L
QEWDI
P
F
E
Q
L
E
I
G
E
L
IGKGRFGQVY
H
G
R
W
H
G
E
V
A
I
R
L
I
D
IERD
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
TRHE
N
V
V
L
F
MGACMSP
P
H
L
A
I
I
T
S
L
CKG
R
T
L
Y
S
V
VRD
A
K
I
V
L
DV
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
AK
G
I
L
H
K
DLKSK
N
V
F
-YD-N
G
K
V
V
-
I
T
DF
G
L
F
S
I
S
G
V
L
Q
AGRRE
D
K
L
R
IQNG
W
L
C
H
L
A
P
E
I
I
R
Q
LSPDTEEDKLPFSKHSD
V
F
A
L
G
T
I
W
Y
E
LHAREWPF-K-T-QPA
E
A
I
I
W
Q-MGTG-M-K-P
N
L
S
--QI------GMG--
K
E
I
S
D
I
L
L
F
C
WAFEQEER
P
T
F
T
K
L
M
D
M
L
E
----
K
L
P
K
RNRRLSHPGHFWKSAEL
1
PsiBlast_PDB
95.37
100%
-140
- C5 -
-
5KKR
1
B:
[19-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Q
T
S
I
F
L
Q
E
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
---
F
G
Q
V
Y
H
G
R
W
H
G
E
V
A
I
R
L
I
D
I
E
R
D
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
R
H
E
N
V
V
L
F
M
G
A
C
M
S
P
P
H
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
R
D
A
K
I
V
L
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
K
G
I
L
H
K
D
L
K
S
K
N
V
F
-
Y
D
-
N
G
K
V
V
-
I
T
D
F
G
L
F
S
I
S
G
V
L
Q
-----
D
K
L
R
I
Q
N
G
W
L
C
H
L
A
P
E
I
I
R
Q
L
S
P
D
---
D
K
L
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
R
E
W
P
F
-
K
-
T
-
Q
P
A
E
A
I
I
W
Q
-
M
G
T
G
-
M
-
K
-
P
N
L
S
--
Q
I
------
G
M
G
--
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
----
K
L
P
------------------
188
HHSearch
95.02
100%
-136
- C5 -
-
2Y4I
1
B:
[22-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
F
L
Q
E
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
K
G
R
F
G
Q
V
Y
H
G
R
W
H
G
E
V
A
I
R
L
I
D
I
E
R
D
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
R
H
E
N
V
V
L
F
M
G
A
C
M
S
P
P
H
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
R
D
A
K
I
V
L
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
K
G
I
L
H
K
D
L
K
S
K
N
V
F
-
Y
D
---
K
V
V
-
I
T
D
F
G
L
F
S
----------
E
D
K
L
R
I
Q
N
G
W
L
C
H
L
A
P
E
I
I
R
Q
L
S
P
D
--
E
D
K
L
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
R
E
W
P
F
-
K
-
T
-
Q
P
A
E
A
I
I
W
Q
-
M
G
T
G
-
M
-
K
-
P
N
L
S
--
Q
I
------
G
M
G
--
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
----
K
L
-------------------
2
PsiBlast_PDB
95.02
100%
-136
- C5 -
-
2Y4I
1
B:
[22-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
I
F
L
Q
E
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
K
G
R
F
G
Q
V
Y
H
G
R
W
H
G
E
V
A
I
R
L
I
D
I
E
R
D
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
R
H
E
N
V
V
L
F
M
G
A
C
M
S
P
P
H
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
R
D
A
K
I
V
L
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
K
G
I
L
H
K
D
L
K
S
K
N
V
F
-
Y
D
---
K
V
V
-
I
T
D
F
G
L
F
S
----------
E
D
K
L
R
I
Q
N
G
W
L
C
H
L
A
P
E
I
I
R
Q
L
S
P
D
--
E
D
K
L
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
R
E
W
P
F
-
K
-
T
-
Q
P
A
E
A
I
I
W
Q
-
M
G
T
G
-
M
-
K
-
P
N
L
S
--
Q
I
------
G
M
G
--
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
----
K
L
-------------------
189
HHSearch
94.72
100%
-142
- C5 -
-
5KKR
1
B:
[21-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
S
I
F
L
Q
E
W
D
I
P
F
E
Q
L
E
I
G
E
L
I
G
---
F
G
Q
V
Y
H
G
R
W
H
G
E
V
A
I
R
L
I
D
I
E
R
D
N
E
D
Q
L
K
A
F
K
R
E
V
M
A
Y
R
Q
T
R
H
E
N
V
V
L
F
M
G
A
C
M
S
P
P
H
L
A
I
I
T
S
L
C
K
G
R
T
L
Y
S
V
V
R
D
A
K
I
V
L
D
V
N
K
T
R
Q
I
A
Q
E
I
V
K
G
M
G
Y
L
H
A
K
G
I
L
H
K
D
L
K
S
K
N
V
F
-
Y
D
-
N
G
K
V
V
-
I
T
D
F
G
L
F
S
I
S
G
V
L
Q
-----
D
K
L
R
I
Q
N
G
W
L
C
H
L
A
P
E
I
I
R
Q
L
S
P
D
---
D
K
L
P
F
S
K
H
S
D
V
F
A
L
G
T
I
W
Y
E
L
H
A
R
E
W
P
F
-
K
-
T
-
Q
P
A
E
A
I
I
W
Q
-
M
G
T
G
-
M
-
K
-
P
N
L
S
--
Q
I
------
G
M
G
--
K
E
I
S
D
I
L
L
F
C
W
A
F
E
Q
E
E
R
P
T
F
T
K
L
M
D
M
L
E
----
K
L
P
------------------
63
Blastp_CBE
71.96
36%
-62
- C5 -
-
2FB8
1
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
21
Blastp_CBE
71.72
37%
-59
- C5 -
-
4YHT
3
B:
[1-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
T
N
E
T
K
F
E
M
T
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
---------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
--
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
T
F
P
Q
I
L
A
S
I
E
----
T
L
A
R
-----------------
84
Blastp_CBE
71.71
36%
-63
- C5 -
-
6N0P
1
B:
[1-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
--------
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
102
Blastp_CBE
71.42
36%
-55
- C5 -
-
4E26
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
--------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
92
Blastp_CBE
71.36
36%
-54
- C5 -
-
6PP9
1
?
A:
[9-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
64
Blastp_CBE
71.00
36%
-66
- C5 -
-
2FB8
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
44
Blastp_CBE
70.89
36%
-51
- C5 -
-
5JSM
6
BRAF_HUMAN
A:
[4-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
E
K
---------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
43
Blastp_CBE
70.75
36%
-64
- C5 -
-
5JSM
5
BRAF_HUMAN
B:
[4-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
E
K
S
R
---------------
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
74
Blastp_CBE
70.66
36%
-63
- C5 -
-
4KSP
1
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
--------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
105
Blastp_CBE
70.61
36%
-64
- C5 -
-
3TV6
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-----------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
110
Blastp_CBE
70.56
36%
-54
- C5 -
-
3Q4C
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
---------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
20
PsiBlast_PDB
70.55
35%
-57
- C5 -
-
4RZV
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
85
Blastp_CBE
70.54
36%
-54
- C5 -
-
6N0P
1
BRAF_HUMAN
A:
[1-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-----
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
111
Blastp_CBE
70.50
36%
-60
- C5 -
-
3PSD
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
130
Blastp_CBE
70.48
36%
-57
- C5 -
-
3IDP
1
B:
[22-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
----------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
54
Blastp_CBE
70.42
36%
-60
- C5 -
-
6N0Q
1
?
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
--------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
--------
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
98
Blastp_CBE
70.29
36%
-53
- C5 -
-
4EHE
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
80
Blastp_CBE
70.24
37%
-68
- C5 -
-
4MNF
1
B:
[42-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
------------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
LLAR
S
--------------------
19
PsiBlast_PDB
70.23
36%
-60
- C5 -
-
4MNF
1
BRAF_HUMAN
A:
[42-313]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
------------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
LLAR
S
--------------------
76
Blastp_CBE
70.17
36%
-61
- C5 -
-
4FC0
1
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
-------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
38
Blastp_CBE
70.16
36%
-81
- C5 -
-
5JT2
2
BRAF_HUMAN
C:
[4-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
E
K
S
R
---------------
S
I
L
W
M
A
P
E
V
I
R
-----------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
--I
N
N
---
I
I
E
M
-
V
G
R
G
---
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
100
Blastp_CBE
70.14
36%
-59
- C5 -
-
4E4X
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
79
Blastp_CBE
70.14
36%
-57
- C5 -
-
4DBN
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
--------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
8
PsiBlast_PDB
70.11
36%
-59
- C5 -
-
4YHT
2
BRAF_HUMAN
A:
[1-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
T
N
E
T
K
F
E
M
T
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
--
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
T
F
P
Q
I
L
A
S
I
E
----
T
L
A
R
-----------------
97
Blastp_CBE
70.10
36%
-63
- C5 -
-
4G9C
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
-----------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
94
Blastp_CBE
70.05
36%
-56
- C5 -
-
4PP7
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
10
PsiBlast_PDB
70.05
35%
-49
- C5 -
-
3C4C
1
BRAF_HUMAN
A:
[6-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
--------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
88
Blastp_CBE
69.97
36%
-60
- C5 -
-
4MBJ
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
78
Blastp_CBE
69.97
36%
-54
- C5 -
-
4DBN
1
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
-------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
114
Blastp_CBE
69.91
36%
-57
- C5 -
-
3PSB
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
62
Blastp_CBE
69.89
36%
-59
- C5 -
-
5CT7
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
112
Blastp_CBE
69.77
36%
-58
- C5 -
-
3PSD
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
121
Blastp_CBE
69.76
36%
-62
- C5 -
-
3PPJ
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
72
Blastp_CBE
69.73
36%
-64
- C5 -
-
4KSQ
1
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
--------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
91
Blastp_CBE
69.71
36%
-60
- C5 -
-
5FD2
1
BRAF_HUMAN
A:
[23-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
138
Blastp_CBE
69.64
36%
-68
- C5 -
-
5HIE
1
D:
[30-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
----------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
104
Blastp_CBE
69.62
36%
-59
- C5 -
-
3TV6
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
59
Blastp_CBE
69.60
36%
-63
- C5 -
-
5VAL
1
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
--------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
99
Blastp_CBE
69.53
36%
-65
- C5 -
-
4EHE
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
118
Blastp_CBE
69.47
36%
-62
- C5 -
-
3PRF
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
60
Blastp_CBE
69.43
36%
-62
- C5 -
-
5VAL
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
--------
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
42
Blastp_CBE
69.43
36%
-58
- C5 -
-
5JSM
4
BRAF_HUMAN
C:
[4-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
E
------------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
-
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
140
Blastp_CBE
69.38
36%
-69
- C5 -
-
5HIE
1
BRAF_HUMAN
B:
[30-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
129
Blastp_CBE
69.35
36%
-50
- C5 -
-
1UWJ
1
BRAF_HUMAN
A:
[2-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
K
---------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
119
Blastp_CBE
69.31
36%
-60
- C5 -
-
3PPK
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
22
Blastp_CBE
69.29
36%
-43
- C5 -
-
6U2H
1
D:
[4-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
---
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
18
PsiBlast_PDB
69.27
35%
-56
- C5 -
-
4WO5
1
BRAF_HUMAN
A:
[26-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
-
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
----
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
135
Blastp_CBE
69.26
36%
-55
- C5 -
-
4G9R
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
K
---------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
46
Blastp_CBE
69.25
36%
-57
- C5 -
-
5JRQ
3
BRAF_HUMAN
A:
[4-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
E
K
S
R
---------------
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
69
Blastp_CBE
69.19
36%
-56
- C5 -
-
4XV2
1
B:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
--
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
----------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
34
Blastp_CBE
69.18
36%
-48
- C5 -
-
4RZV
1
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
---
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
56
Blastp_CBE
69.17
36%
-66
- C5 -
-
6B8U
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
139
Blastp_CBE
69.16
36%
-64
- C5 -
-
5HIE
1
BRAF_HUMAN
C:
[30-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
----------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
58
Blastp_CBE
69.09
36%
-49
- C5 -
-
5VAM
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
----
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
49
Blastp_CBE
69.07
36%
-55
- C5 -
-
4R5Y
1
BRAF_HUMAN
A:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
51
Blastp_CBE
69.03
36%
-59
- C5 -
-
1UWH
1
B:
[2-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
109
Blastp_CBE
69.02
36%
-61
- C5 -
-
3SKC
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
----------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
107
Blastp_CBE
68.99
36%
-61
- C5 -
-
3TV4
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
--
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
13
PsiBlast_PDB
68.97
35%
-61
- C5 -
-
5ITA
1
BRAF_HUMAN
A:
[22-292]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
---------------------
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
------------------
53
Blastp_CBE
68.95
36%
-65
- C5 -
-
6N0Q
1
?
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
--------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
50
Blastp_CBE
68.94
36%
-55
- C5 -
-
4FK3
1
BRAF_HUMAN
A:
[18-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
--------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
------------------
133
Blastp_CBE
68.93
36%
-61
- C5 -
-
5C9C
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
-------------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
126
Blastp_CBE
68.93
36%
-50
- C5 -
-
5HID
3
BRAF_HUMAN
A:
[14-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
------------
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
122
Blastp_CBE
68.87
36%
-61
- C5 -
-
3PPJ
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
108
Blastp_CBE
68.86
36%
-57
- C5 -
-
3SKC
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
52
Blastp_CBE
68.85
36%
-58
- C5 -
-
1UWH
1
BRAF_HUMAN
A:
[2-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
96
Blastp_CBE
68.74
36%
-63
- C5 -
-
4G9C
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
113
Blastp_CBE
68.70
36%
-61
- C5 -
-
3PSB
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
70
Blastp_CBE
68.67
36%
-54
- C5 -
-
4XV2
1
BRAF_HUMAN
A:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
-----------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
123
Blastp_CBE
68.66
36%
-59
- C5 -
-
3D4Q
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
29
Blastp_CBE
68.65
36%
-49
- C5 -
-
4JVG
1
BRAF_HUMAN
A:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
----------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
24
Blastp_CBE
68.64
36%
-58
- C5 -
-
5CSW
1
B:
[8-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
---------------------
S
I
L
W
M
A
P
E
V
I
R
-----------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
11
PsiBlast_PDB
68.63
35%
-58
- C5 -
-
5CSW
1
BRAF_HUMAN
A:
[8-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
39
Blastp_CBE
68.60
36%
-58
- C5 -
-
5JT2
2
BRAF_HUMAN
B:
[4-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
-------------------
S
I
L
W
M
A
P
E
V
I
R
M
--------
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
77
Blastp_CBE
68.57
36%
-63
- C5 -
-
4FC0
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
134
Blastp_CBE
68.53
36%
-50
- C5 -
-
4G9R
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
K
----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
47
Blastp_CBE
68.52
36%
-53
- C5 -
-
3OG7
1
BRAF_HUMAN
A:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
A
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
---
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
----------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
124
Blastp_CBE
68.49
36%
-58
- C5 -
-
3D4Q
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
14
PsiBlast_PDB
68.44
35%
-52
- C5 -
-
4XV9
1
A:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
--------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
9
PsiBlast_PDB
68.44
35%
-53
- C5 -
-
6U2H
1
BRAF_HUMAN
C:
[4-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
--------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
73
Blastp_CBE
68.39
36%
-56
- C5 -
-
4KSQ
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
--------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
131
Blastp_CBE
68.38
36%
-59
- C5 -
-
3IDP
1
BRAF_HUMAN
A:
[22-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
--
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
6
PsiBlast_PDB
68.38
36%
-44
- C5 -
-
6NYB
1
?
A:
[476-758]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
LLAR
S
L
P
K
I
H
R
S
A
S
E
P
---------
132
Blastp_CBE
68.32
36%
-64
- C5 -
-
5C9C
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
---------------------
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
71
Blastp_CBE
68.31
36%
-57
- C5 -
-
4XV1
1
BRAF_HUMAN
A:
[18-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
-
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
--
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
--------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
----------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
--------
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
--------------------
136
Blastp_CBE
68.27
36%
-57
- C5 -
-
4EHG
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
----------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
101
Blastp_CBE
68.27
36%
-66
- C5 -
-
4E4X
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
55
Blastp_CBE
68.24
36%
-59
- C5 -
-
6B8U
1
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
----
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
61
Blastp_CBE
68.20
36%
-61
- C5 -
-
5CT7
1
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
31
Blastp_CBE
68.18
36%
-52
- C5 -
-
4WO5
1
B:
[27-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
120
Blastp_CBE
68.13
36%
-59
- C5 -
-
3PPK
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
40
Blastp_CBE
68.11
36%
-59
- C5 -
-
5JT2
2
BRAF_HUMAN
A:
[4-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
E
K
S
R
W
--------------
S
I
L
W
M
A
P
E
V
I
------------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
--
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
117
Blastp_CBE
68.05
36%
-56
- C5 -
-
3PRF
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
106
Blastp_CBE
68.05
36%
-55
- C5 -
-
3TV4
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
15
PsiBlast_PDB
68.05
35%
-53
- C5 -
-
4JVG
1
BRAF_HUMAN
B:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
-------------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
37
Blastp_CBE
68.00
36%
-91
- C5 -
-
5JT2
2
D:
[4-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
E
------------------
S
I
L
W
M
A
P
E
V
I
R
----------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
--------------------
S
-
P
D
L
S
--
K
V
------
R
-
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
------------------
48
Blastp_CBE
67.88
36%
-52
- C5 -
-
4R5Y
1
B:
[18-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
-----------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
----------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
67
Blastp_CBE
67.86
36%
-64
- C5 -
-
3Q96
1
BRAF_HUMAN
A:
[4-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
---------------------
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
17
PsiBlast_PDB
67.84
35%
-46
- C5 -
-
6NSQ
1
B:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
-----------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
30
Blastp_CBE
67.82
36%
-52
- C5 -
-
5ITA
1
B:
[22-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
---------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
-
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
41
Blastp_CBE
67.80
36%
-59
- C5 -
-
5JSM
4
D:
[4-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
E
K
S
--------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I---
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
75
Blastp_CBE
67.73
36%
-61
- C5 -
-
4KSP
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
141
Blastp_CBE
67.72
36%
-70
- C5 -
-
5HIE
1
BRAF_HUMAN
A:
[30-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
--------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
66
Blastp_CBE
67.67
36%
-57
- C5 -
-
3Q96
1
B:
[4-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
-------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
86
Blastp_CBE
67.61
36%
-59
- C5 -
-
3II5
1
B:
[29-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
-------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
93
Blastp_CBE
67.59
36%
-51
- C5 -
-
6U2G
1
MP2K1_HUMAN
B:
[32-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
--------
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
143
Blastp_CBE
67.56
34%
-78
- C5 -
-
3OMV
1
RAF1_HUMAN
A:
[29-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
---
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
M
T
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
Q
E
T
K
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
H
R
D
M
K
S
N
N
I
F
-
L
H
-
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
---------------
P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
------
Q
D
N
N
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
Y
-
S
H
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
-
Y
A
S
-
P
D
L
S
--
K
L
YKNCPK
A
M
K
--
R
L
V
A
D
----
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
LLQH
S
L
P
K
-----------------
23
Blastp_CBE
67.54
36%
-50
- C5 -
-
3C4C
1
B:
[6-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
---------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
57
Blastp_CBE
67.53
36%
-63
- C5 -
-
5VAM
1
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
----
R
W
------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
28
Blastp_CBE
67.49
36%
-49
- C5 -
-
4JVG
1
BRAF_HUMAN
C:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
--------------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
45
Blastp_CBE
67.47
36%
-80
- C5 -
-
5JRQ
2
B:
[4-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
--
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
E
-------------------
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
--------
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
95
Blastp_CBE
67.40
36%
-62
- C5 -
-
4PP7
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
137
Blastp_CBE
67.33
36%
-63
- C5 -
-
4EHG
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
-----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
185
HHSearch
67.30
37%
-61
- C5 -
-
6NYB
1
?
A:
[396-748]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
T
-
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
-
L
H
E
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
---
S
H
Q
F
E
Q
L
S
G
S
I
L
W
M
A
P
E
V
I
R
M
Q
D
------
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
-
I
N
N
R
D
Q
I
I
F
M
V
G
R
G
-
Y
-
L
S
P
D
L
S
KV
R
S
------
N
C
P
--
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
S
L
---------------
125
Blastp_CBE
67.15
36%
-47
- C5 -
-
5HID
3
B:
[14-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
G
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
115
Blastp_CBE
67.12
36%
-54
- C5 -
-
3PRI
1
B:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
87
Blastp_CBE
67.05
36%
-55
- C5 -
-
3II5
1
BRAF_HUMAN
A:
[29-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
-----------
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
36
Blastp_CBE
67.04
36%
-48
- C5 -
-
4CQE
1
BRAF_HUMAN
A:
[4-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
--
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
--
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
89
Blastp_CBE
67.00
36%
-65
- C5 -
-
4MBJ
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
27
Blastp_CBE
66.97
36%
-48
- C5 -
-
4JVG
1
D:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
----------------
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
68
Blastp_CBE
66.96
36%
-56
- C5 -
-
4XV3
1
BRAF_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
--
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
--------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
----------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
-------------------
25
Blastp_CBE
66.93
36%
-36
- C5 -
-
6NSQ
1
BRAF_HUMAN
A:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
W
S
-
S
H
Q
F
E
Q
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
S
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
33
Blastp_CBE
66.75
36%
-55
- C5 -
-
4RZW
1
BRAF_HUMAN
A:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
----------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
12
PsiBlast_PDB
66.65
35%
-50
- C5 -
-
5CSX
2
A:
[8-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
A
T
V
K
S
R
-------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
--
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
26
Blastp_CBE
66.54
36%
-52
- C5 -
-
6CAD
1
B:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
--
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
-
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
---------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
----------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
127
Blastp_CBE
66.30
36%
-58
- C5 -
-
5HI2
1
A:
[14-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
L
---------------------
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
142
Blastp_CBE
66.28
34%
-78
- C5 -
-
3OMV
1
B:
[29-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Y
---
W
E
I
E
A
S
E
V
M
L
S
T
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
I
L
K
V
V
D
P
T
P
E
Q
F
Q
A
F
R
N
E
V
A
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
-
Y
M
T
K
D
N
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
K
H
L
H
V
Q
E
T
K
F
Q
M
F
Q
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
N
I
I
H
R
D
M
K
S
N
N
I
F
-
L
H
-
E
G
L
T
V
K
I
G
D
F
G
L
A
T
V
---------------
P
T
G
S
V
L
W
M
A
P
E
V
I
R
M
------
Q
D
N
N
P
F
S
F
Q
S
D
V
Y
S
Y
G
I
V
L
Y
E
L
M
T
G
E
L
P
Y
-
S
H
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
-
Y
A
S
-
P
D
L
S
--
K
L
YKNCPK
A
M
K
--
R
L
V
A
D
----
C
V
K
K
V
K
E
E
R
P
L
F
P
Q
I
L
S
S
I
E
LLQH
S
L
P
K
-----------------
128
Blastp_CBE
66.23
36%
-51
- C5 -
-
1UWJ
1
B:
[2-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
E
K
----------------
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
116
Blastp_CBE
66.14
36%
-55
- C5 -
-
3PRI
1
BRAF_HUMAN
A:
[30-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
L
A
T
V
------------
L
---
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
35
Blastp_CBE
65.71
36%
-57
- C5 -
-
4CQE
1
B:
[4-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
---
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
---------------------
G
S
I
L
W
M
A
P
E
V
I
R
----------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
16
PsiBlast_PDB
65.33
35%
-50
- C5 -
-
6CAD
1
BRAF_HUMAN
A:
[10-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
-
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
--
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
G
--------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
----------
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I-
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
32
Blastp_CBE
65.23
36%
-54
- C5 -
-
4RZW
1
B:
[7-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
V
G
Q
R
I
G
S
G
S
F
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
N
V
T
A
P
T
P
Q
Q
L
Q
A
F
K
N
E
V
G
V
L
R
K
T
H
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
A
S
E
T
K
F
E
M
K
K
L
I
D
I
A
R
Q
T
A
R
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
N
T
V
K
-
I
G
D
F
----------------------
G
S
I
L
W
M
A
P
E
V
I
R
M
---------
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
-
S
-
N
I
N
N
R
D
Q
I
I
E
M
-
V
G
R
G
S
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
R
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
S
F
P
R
I
L
A
E
I
E
----
E
L
A
R
-----------------
90
Blastp_CBE
63.10
36%
-65
- C5 -
-
5FD2
1
B:
[23-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
E
I
P
D
G
Q
I
T
----------
G
T
V
Y
K
G
K
W
H
G
D
V
A
V
K
M
L
-----------
A
F
K
N
E
V
G
V
L
R
K
T
R
H
V
N
I
L
L
F
M
G
Y
S
-
T
K
P
Q
L
A
I
V
T
Q
W
C
E
G
S
S
L
Y
H
H
L
H
I
I
E
T
K
F
E
M
I
K
L
I
D
I
A
R
Q
T
A
Q
G
M
D
Y
L
H
A
K
S
I
I
H
R
D
L
K
S
N
N
I
F
L
H
E
-
D
L
T
V
K
-
I
G
D
F
G
--------------------
S
G
S
I
L
W
M
A
P
E
V
I
R
M
------
Q
D
K
N
P
Y
S
F
Q
S
D
V
Y
A
F
G
I
V
L
Y
E
L
M
T
G
Q
L
P
Y
S
N
-
I
-
N
N
R
D
Q
I
I
F
M
-
V
G
R
G
Y
L
-
S
-
P
D
L
S
--
K
V
------
R
S
N
CP
K
A
M
K
R
L
M
A
E
C
L
K
K
K
R
D
E
R
P
L
F
P
Q
I
L
A
S
I
E
----
L
L
A
R
-----------------
-
* C *
-
-
:
-------------------------