@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : LMTK2_HUMAN: (2020-09-13 )
MPGPPALRRRLLLLLLVLLIAGSAGAAPLPQTGAGEAPPAAEVSSSFVILCVCSLIILIVLIANCVSCCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSVQSPAEVFTLSVPNISLPAPSQFQPSVEGLKSQVARHSLNYIQEIGNGWFGKVLLGEIYTGTSVARVIVKELKASANPKEQDTFLKNGEPYYILQHPNILQCVGQCVEAIPYLLVFEFCDLGDLKAYLRSEQEHMRGDSQTMLLQRMACEVAAGLAAMHKLHFLHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDDKKVFPLRWTAPELVTSFQDRLLTADQTKYSNIWSLGVTLWELFDNAAQPYSNLSNLDVLNQVIRERDTKLPKPQLEQPYSDRWYEVLQFCWLSPEKRPAAEDVHRLLTYLRLQSQRDSEVDFEQQWNALKPNTNSRDSSNNAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAKHDHFDERSRGHLDEGLSYTSIFYPVEVFESSLSDPGPGKQDDSGQDVPLRVPGVVPVFDAHNLSVGSDYYIQLEEKSGSNLELDYPPALLTTDMDNPERTGPELSQLTALRSVELEESSTDEDFFQSSTDPKDSSLPGDLHVTSGPESPFNNIFNDVDKSEDLPSHQKIFDLMELNGVQADFKPATLSSSLDNPKESVITGHFEKEKPRKIFDSEPLCLSDNLMHQDNFDPLNVQELSENFLFLQEKNLLKGSLSSKEHINDLQTELKNAGFTEAMLETSCRNSLDTELQFAENKPGLSLLQENVSTKGDDTDVMLTGDTLSTSLQSSPEVQVPPTSFETEETPRRVPPDSLPTQGETQPTCLDVIVPEDCLHQDISPDAVTVPVEILSTDARTHSLDNRSQDSPGESEETLRLTESDSVLADDILASRVSVGSSLPELGQELHNKPFSEDHHSHRRLEKNLEAVETLNQLNSKDAAKEAGLVSALSSDSTSQDSLLEDSLSAPFPASEPSLETPDSLESVDVHEALLDSLGSHTPQKLVPPDKPADSGYETENLESPEWTLHPAPEGTADSEPATTGDGGHSGLPPNPVIVISDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEPEKRSEEVPGTSPSALVLVQEQPLPEPVLPEQSPAAQDSCLEARKSQPDESCLSALHNSSDLELRATPEPAQTGVPQQVHPTEDEASSPWSVLNAELSSGDDFETQDDRPCTLASTGTNTNELLAYTNSALDKSLSSHSEGPKLKEPDIEGKYLGKLGVSGMLDLSEDGMDADEEDENSDDSDEDLRAFNLHSLSSESEDETEHPVPIILSNEDGRHLRSLLKPTAANAPDPLPEDWKKEKKAVTFFDDVTVYLFDQETPTKELGPCGGEACGPDLSGPAPASGSPYLSRCINSESSTDEEGGGFEWDDDFSPDPFMSKTTSNLLSSKPSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPANIASFSLTHLTDSDIEQGGSSEDGEKD
Atome Classification :
(92 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140-------........150..---...---.---.160.......170.......180.......190.......200...--.----.-..210........220....---..-----.----------230-.----......240-..----......250.......260.......270...---....280.......290.........---300-........310.......320.......330.......340.......350.......360.......370---......-.380.........390.-.-......-400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPG
P
P
A
L
R
R
R
L
L
L
L
L
L
V
L
L
IAGSAGAAPLPQTGAGEAPP
A
A
EVSS
S
F
V
I
L
C
V
C
S
L
I
I
L
I
V
L
I
A
N
C
V
S
C
CKDPEI
D
F
K
E
FEDNFDDEIDFTPPAEDTPSVQSP
A
E
V
F
T
L
SVPNISLPAPSQFQ
P
S
V
E
G
L
K
S
Q
V
A
R
H
S
L
N
Y
I
Q
--------
E
IGNGW
F
G
K
V
L
L
G
---EIY---T---
G
T
S
V
A
R
V
I
V
K
E
L
K
ASANP
K
E
Q
DTFLKNG
E
P
Y
Y
I
LQHP
N
I
L
Q
C
V
G
Q
C
V
--
E
----
A
-
I
P
Y
-
L
L
V
F
E
FC
D
L
G
D
L
K
A
Y
L
---
R
S
-----
E
----------
Q
E
H-M----RG
D
S
Q
T
M
L
--
L
Q
----
R
M
A
C
E
V
A
A
G
L
A
A
M
H
K
L
H
F
L
H
S
D
L
A
L
R
N
C
FLTS---DL
N
V
K
VGDYGI
G
F
S
R
--
Y
K
E
D
YIETD---D
K
--
K
V
F
P
L
RWT
A
P
E
L
V
T
S
F
Q
D
R
LLTADQTKYS
N
I
W
S
L
G
V
T
L
W
E
L
F
D
N
AAQPYSNLS
N
L
D
V
L
N
Q
V
I
R
E
RDTKLPK---PQLEQP-Y
S
--
D
R
W
Y
E
V
L
Q
F
C
W-L-S-PEKR
P
A
-
A
E
D
V
H
R
L
L
T
Y
L
R
L
QSQRDSEV
D
F
E
Q
QWNALKPNTNSRDSSNNAA
F
P
I
L
D
H
F
A
R
D
R
L
G
R
E
M
E
E
V
L
T
V
TETSQG
L
S
F
E
Y
V
W
E
A
AKHDHF
D
E
RSRGHLDEGLSY
T
S
I
F
Y
P
V
E
V
F
E
S
SLSDPGPGKQDDSGQDV
P
L
RVP
G
V
V
P
VFDAHNLSVG
S
D
Y
Y
I
Q
L
EEKSGSN
L
E
LDYPPALLTTDMDNPERTGP
E
L
S
Q
L
T
A
L
R
S
V
E
LEESST
D
E
D
F
FQSSTDPKDSSLPG
D
L
H
VTSGPES
P
F
N
N
I
F
NDVDKSEDLP
S
H
Q
K
I
F
D
L
M
E
LNGVQADFKPATLSSSLDNP
K
E
S
V
I
TGHFEKEK
P
R
KIFDSEPLCLSDNLMHQDNFDPL
N
V
Q
E
L
S
E
N
F
L
F
L
QEKNLLKGSLS
S
K
E
H
I
N
D
L
Q
T
E
L
KNAG
F
T
E
A
M
L
E
T
S
CRNSLDT
E
L
Q
FAENKP
G
L
S
L
L
Q
E
N
VSTKGDDT
D
V
M
L
TGDTL
S
T
S
LQSSPEVQVPPTSFETEETPRRVPPDSLPTQGETQP
T
C
L
D
V
IV
P
E
D
C
L
HQDISPD
A
V
T
V
P
V
E
I
LSTDARTHSLDNRSQDSPGESE
E
T
L
R
LTESDS
V
L
A
D
D
I
L
A
S
R
V
SVGSS
L
P
E
L
G
Q
E
L
HNKPFS
E
D
H
H
S
H
R
R
L
E
K
N
L
E
A
V
E
T
L
N
Q
LNS
K
D
A
A
K
E
A
G
L
V
S
ALSSDSTS
Q
D
S
L
L
E
D
SLSAPFPASEPSLETPDSLES
V
D
V
H
E
A
L
L
D
S
L
GSHTPQKLVPPDKPADSGYETENLESPE
W
T
LHPAPEGTADSEPATTGDGGHSGLPPN
P
V
I
V
I
SDAGDGHRGTEVTPETFTAGSQGSYRDSAYFSDNDSEP
E
K
R
SEEVPGTSP
S
A
L
V
L
V
QEQPLPEPVLPEQSPAA
Q
D
S
C
L
E
A
RKSQP
D
E
S
C
L
S
A
LHNSSD
L
E
L
R
ATPEPAQTGVPQQVHPTEDEASSP
W
S
V
L
N
A
ELSSGDDFETQDDRP
C
T
L
ASTGTN
T
N
E
L
L
A
Y
T
N
S
A
L
D
K
S
L
S
SHSEGPKLKEPDIE
G
K
Y
L
G
KLGVSGMLDLSEDGMDADEEDENSDDS
D
E
D
L
R
A
F
N
LHSLSSESEDETEHP
V
P
I
I
L
SNED
G
R
H
L
R
S
L
LKPTAANAPDPL
P
E
D
W
K
K
EK
K
A
V
T
F
FD
D
V
T
V
Y
L
FDQETP
T
K
ELGPCGGEACGPDLSGPAPASG
S
P
Y
L
S
R
C
INSESSTDEEGGGFEWDDDFSPDPF
M
S
K
T
T
S
N
L
LSSKPSLQTSKYFSPPPPARSTEQSWPHSAPYSRFSISPAN
I
A
S
F
S
L
T
HL
T
D
S
D
I
EQGGSSEDGEKD
157
Blastp_CBE
87.40
31%
-113
- C1 -
-
3SXS
1
A:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
--------
E
L
G
S
G
Q
F
G
V
V
K
L
G
---
K
W
K
---
G
---
Q
Y
D
V
A
V
K
M
I
K
E
G
S
M
S
-----
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
--
K
----
E
-
Y
P
I
-
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
---
R
S
------------------
H
-
G
----
K
G
L
E
P
S
Q
L
--
L
E
-----
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
---
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
--
L
D
D
Q
Y
V
S
S
V
---
G
T
--
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
-------
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
--
S
Q
G
H
R
L
Y
R
---
P
H
L
A
----
S
--
D
T
I
Y
Q
I
M
Y
S
C
W
-
H
-
E
L
P
E
K
R
P
T
-
F
Q
Q
L
L
S
S
I
E
P
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
84.86
33%
-117
- C1 -
-
4CSV
1
?
A:
[5-266]
--------------------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
S
E
I
T
L
E
R
--------
K
L
G
S
G
Q
F
G
E
V
Y
E
G
---
K
-
W
---
R
---
N
Y
N
I
-
E
V
A
V
K
T
L
K
E
G
T
M
S
V
E
E
--
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
--
K
----
E
-
P
P
I
-
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
---
R
D
-----
C
-------------------
V
-
N
A
Q
A
L
L
--------
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
N
V
V
K
V
A
D
F
G
-------------------------
F
P
I
K
W
T
A
P
E
A
I
S
--
Y
N
R
F
-----
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
--
E
R
G
Y
R
M
P
R
---
P
---
Q
G
-
C
P
--
E
E
I
Y
E
L
M
L
Q
C
W
N
K
-
S
-
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
84.67
31%
-115
- C1 -
-
3SXR
1
B:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
--------
E
L
------
V
V
K
L
G
---
K
W
K
---
G
---
Q
Y
D
V
A
V
K
M
I
K
E
G
S
M
S
-----
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
--
K
----
E
-
Y
P
I
-
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
---
R
S
------------------
H
-
G
----
K
G
L
E
P
S
Q
L
--
L
E
-----
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
---
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
--
L
D
D
Q
Y
V
S
S
V
---
G
T
--
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
-------
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
--
S
Q
G
H
R
L
Y
R
---
P
H
L
A
----
S
--
D
T
I
Y
Q
I
M
Y
S
C
W
-
H
-
E
L
P
E
K
R
P
T
-
F
Q
Q
L
L
S
S
I
E
P
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
84.52
33%
-111
- C1 -
-
4UEU
1
?
A:
[5-266]
--------------------------------------------------------------------------------------------------------------------------------
K
W
E
I
P
R
S
E
I
T
L
E
R
--------
K
L
G
S
G
Q
F
G
E
V
Y
E
G
---
K
-
W
---
R
---
N
Y
N
I
-
E
V
A
V
K
T
L
K
E
G
T
M
S
V
E
E
--
F
L
Q
E
A
Q
I
M
K
K
L
K
H
P
N
L
V
Q
L
Y
G
V
C
T
--
K
----
E
-
P
P
I
-
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
---
R
D
-----
C
----------
E
G
H
-
T
----
V
-
N
A
Q
A
L
L
--------
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
---------------
A
--
K
-
F
P
I
K
W
T
A
P
E
A
I
S
--
Y
N
R
F
-----
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
--
E
R
G
Y
R
M
P
R
---
P
---
Q
G
-
C
P
--
E
E
I
Y
E
L
M
L
Q
C
W
N
K
-
S
-
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
84.40
31%
-114
- C1 -
-
3SXR
1
BMX_HUMAN
A:
[4-263]
----------------------------------------------------------------------------------------------------------------------------------
E
L
K
R
E
E
I
T
L
L
K
--------
E
L
G
S
----
V
V
K
L
G
---
K
W
K
---
G
---
Q
Y
D
V
A
V
K
M
I
K
E
G
S
M
S
-----
E
D
E
F
F
Q
E
A
Q
T
M
M
K
L
S
H
P
K
L
V
K
F
Y
G
V
C
S
--
K
----
E
-
Y
P
I
-
Y
I
V
T
E
Y
I
S
N
G
C
L
L
N
Y
L
---
R
S
------------------
H
-
G
----
K
G
L
E
P
S
Q
L
--
L
E
-----
M
C
Y
D
V
C
E
G
M
A
F
L
E
S
H
Q
F
I
H
R
D
L
A
A
R
N
C
L
V
D
R
---
D
L
C
V
K
V
S
D
F
G
M
T
R
Y
V
--
L
D
D
Q
Y
V
S
S
V
---
G
T
--
K
-
F
P
V
K
W
S
A
P
E
V
F
H
Y
F
K
-------
Y
S
S
K
S
D
V
W
A
F
G
I
L
M
W
E
V
F
S
L
G
K
M
P
Y
D
L
Y
T
N
S
E
V
V
L
K
V
--
S
Q
G
H
R
L
Y
R
---
P
H
L
A
----
S
--
D
T
I
Y
Q
I
M
Y
S
C
W
-
H
-
E
L
P
E
K
R
P
T
-
F
Q
Q
L
L
S
S
I
E
P
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
84.23
34%
-112
- C1 -
-
4M14
2
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
--
L
D
D
Q
Y
T
S
S
T
---
G
T
--
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
83.90
34%
-113
- C1 -
-
3MJ2
1
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
--
L
D
D
Q
Y
T
S
S
T
---
G
T
--
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
83.85
34%
-114
- C1 -
-
4M0Z
2
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
--
L
D
D
Q
Y
T
S
S
T
---
G
T
--
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
83.82
34%
-128
- C1 -
-
3QGW
1
B:
[29-279]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
I
K
T
I
K
E
G
S
M
S
-----
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
---------------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
83.70
34%
-113
- C1 -
-
4M0Y
2
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
--
L
D
D
Q
Y
T
S
S
T
---
G
T
--
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
83.58
34%
-112
- C1 -
-
4M13
1
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
--
L
D
D
Q
Y
T
S
S
T
---
G
T
--
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
83.28
34%
-109
- C1 -
-
4M12
1
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
--
L
D
D
Q
Y
T
S
S
T
---
G
T
--
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
83.02
34%
-115
- C1 -
-
4M15
2
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
--
L
D
D
Q
Y
T
S
S
T
---
G
T
--
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
82.68
33%
-116
- C1 -
-
3T9T
3
A:
[10-260]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
T
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
--
L
D
D
Q
Y
T
S
S
T
---
G
T
--
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
82.52
34%
-113
- C1 -
-
4HCV
1
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
--
L
D
D
Q
Y
T
S
S
T
---
G
T
--
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
82.51
34%
-117
- C1 -
-
3QGY
1
B:
[29-279]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
I
K
T
I
K
E
G
S
M
S
-----
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
82.21
34%
-115
- C1 -
-
4HCT
1
A:
[12-262]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
--
L
D
D
Q
Y
T
S
S
T
---
G
T
--
K
-
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
R
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
82.18
34%
-127
- C1 -
-
3QGY
1
ITK_HUMAN
A:
[29-279]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
I
K
T
I
K
E
G
S
M
S
-----
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
82.09
34%
-127
- C1 -
-
3QGW
1
ITK_HUMAN
A:
[29-279]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
I
K
T
I
K
E
G
S
M
S
-----
E
D
D
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
-------------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
82.07
31%
-119
- C1 -
-
6HVE
1
?
A:
[14-269]
----------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
E
S
L
R
L
E
V
--------
K
L
G
Q
G
C
F
G
E
V
W
M
G
----
T
W
---
N
---
G
T
T
--
R
V
A
I
K
T
L
K
P
G
T
M
S
P
E
--
A
F
L
Q
E
A
Q
V
M
K
K
L
R
H
E
K
L
V
Q
L
Y
A
V
V
S
--
E
----
E
--
P
I
-
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
---
K
G
-----
E
----------
M
G
K
-
Y
----
L
R
L
P
Q
-----
L
V
----
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
---
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--
E
-----------------
F
P
I
K
W
T
A
P
E
A
A
-------
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
R
V
P
Y
P
G
M
V
N
R
E
V
L
D
Q
V
--
E
R
G
Y
R
M
P
C
---
P
P
-
E
C
P
-
E
S
----
L
H
D
L
M
C
Q
C
W
-
R
-
K
D
P
E
E
R
P
T
-
F
E
Y
L
Q
A
F
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
81.86
34%
-124
- C1 -
-
4PP9
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
-------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
81.69
34%
-117
- C1 -
-
4L7S
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
--
T
----------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
81.57
34%
-118
- C1 -
-
4L7S
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
--
T
----------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
81.53
34%
-127
- C1 -
-
3V8W
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
-
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
81.37
34%
-134
- C1 -
-
3V5J
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
----
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
---------------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
81.34
34%
-123
- C1 -
-
3V8T
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
---
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
81.20
34%
-122
- C1 -
-
1SM2
1
ITK_HUMAN
A:
[7-257]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
80.97
34%
-131
- C1 -
-
3V5J
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
-
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
--
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
--
S
T
G
-
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
80.92
34%
-122
- C1 -
-
3V5L
1
ITK_HUMAN
C:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
---
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
80.91
34%
-124
- C1 -
-
4KIO
3
D:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
-----
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
-------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
80.88
34%
-126
- C1 -
-
3V8W
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
---
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
80.88
34%
-122
- C1 -
-
4PP9
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
80.64
34%
-121
- C1 -
-
4KIO
3
ITK_HUMAN
C:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
--
T
---------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
80.53
34%
-120
- C1 -
-
1SNU
1
ITK_HUMAN
A:
[7-257]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
80.49
34%
-122
- C1 -
-
3V5L
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
----
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
80.37
34%
-129
- C1 -
-
4RFM
1
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
----------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
80.23
34%
-126
- C1 -
-
1SNU
1
B:
[7-257]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
---------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
80.12
33%
-54
- C1 -
-
5H3Q
3
A:
[32-312]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
------
K
M
L
V
A
V
K
A
L
K
E
----
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPDAKLLAGG
E
D
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
--
Y
S
T
D
Y
Y
R
V
G
---
G
R
--
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
79.95
34%
-132
- C1 -
-
4KIO
2
ITK_HUMAN
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
---
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
-------
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
--
T
----------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
79.89
34%
-128
- C1 -
-
4KIO
2
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
---
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
------
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
--
T
----------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
79.82
34%
-128
- C1 -
-
3V5L
1
D:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
-
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
--
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
------------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
79.55
34%
-127
- C1 -
-
3MIY
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
-----
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
---------------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
79.50
34%
-128
- C1 -
-
3MIY
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
-----
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
79.40
34%
-129
- C1 -
-
1SM2
1
B:
[7-257]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
---------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
79.07
34%
-126
- C1 -
-
3V5L
1
ITK_HUMAN
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
----
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
----
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
79.00
34%
-117
- C1 -
-
4PQN
2
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
-------------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
78.84
34%
-120
- C1 -
-
4MF1
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
---
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
-------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
78.63
33%
-21
- C1 -
-
5KML
1
A:
[32-312]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP--
D
K
M
L
V
A
V
K
A
L
K
E
-
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPDAG-----
E
D
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
--
Y
S
T
D
Y
Y
R
V
G
---
G
R
--
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
78.05
34%
-116
- C1 -
-
4MF1
1
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
---
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
T
R
----------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
78.04
34%
-122
- C1 -
-
3V8T
1
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
---
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
R
E
G
A
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
-------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
------
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
77.70
34%
-131
- C1 -
-
3MJ1
1
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
-------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
S
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
---------------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
-
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
77.25
32%
-30
- C1 -
-
5KVT
2
A:
[4-278]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
L----
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPDAKLLAGG
E
D
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
--
Y
S
T
D
Y
Y
R
V
G
---
G
R
--
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
77.04
33%
-18
- C1 -
-
5KMO
1
A:
[31-311]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP
E
Q
D
K
M
L
V
A
V
K
A
L
K
---
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPDAKLGG--
E
D
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
--
R
D
I
--
Y
S
T
D
Y
Y
R
V
G
---
G
R
--
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
76.92
33%
-51
- C1 -
-
4AOJ
1
C:
[37-317]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP-
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPD-----------------
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
M
-----------------------
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
76.78
34%
-24
- C1 -
-
4AT3
1
A:
[9-287]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
H
N
I
V
L
K
R
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
Y
---
N
LC----
K
I
L
V
A
V
K
T
L
--
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
Q
H
E
H
I
V
K
F
Y
G
V
C
V
--
E
----
G
-
D
P
L
-
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
---
R
A
-----
H
----------
G
P
D
-
A
VLMA--
N
P
P
T
E
L
--
T
Q
SQML
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
---
N
L
L
V
K
I
G
D
F
G
M
S
R
----
Y
S
T
D
Y
Y
R
V
G
---
G
H
--
T
M
L
P
I
R
W
M
P
P
E
---
S
I
M
Y
R
K
F
T
T
E
----
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
E
C
I
T
Q
G
R
V
L
Q
R
P
R
TC-
P
Q
----------
E
V
Y
E
L
M
L
G
C
W
Q
R
-
E
-
P
H
M
R
K
N
-
I
K
G
I
H
T
L
L
Q
N
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
76.66
31%
-51
- C1 -
-
3L9P
4
A:
[61-331]
---------------------------------------------------------------------------------------------------------------------------
S
I
S
D
L
K
-
E
V
P
R
K
N
I
T
L
I
R
--------
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
----
S
---
G
-
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
----
S
-
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
---
R
E
-----
T
----------
R
P
R
P
S
----
Q
P
S
S
L
A
M
L
D-
L
L
----
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--
Y
R
A
G
Y
Y
R
K
G
---
G
C
--
A
M
L
P
V
K
W
M
P
P
E
---
A
F
M
E
G
I
F
T
S
K
----
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
----
N
C
P
G
P
-
V
------
Y
R
I
M
T
Q
C
W
-
Q
H
Q
-
P
E
D
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
76.66
33%
-32
- C1 -
-
6DKB
1
A:
[28-308]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
G------------------
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
--------
S
T
D
Y
Y
R
----------
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
-
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
76.63
33%
-34
- C1 -
-
6DKG
2
A:
[28-308]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPD-----------------
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
-------
Y
S
T
D
Y
Y
-------
R
--
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
-
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
76.61
33%
-47
- C1 -
-
4AOJ
1
NTRK1_HUMAN
A:
[37-317]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP---
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPD----------------
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
-----------------------
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.93
32%
-35
- C1 -
-
6J5L
1
A:
[11-291]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
L----
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPDAKLLAGG
E
D
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
----
I
--
Y
S
T
D
Y
Y
R
V
--------
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
75.83
33%
-13
- C1 -
-
6PL2
1
A:
[20-300]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPDAKLLAGG
E
D
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
--
Y
T
-
D
Y
Y
R
V
G
---
G
R
--
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
-
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
75.80
32%
-11
- C1 -
-
4PMP
1
A:
[4-284]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LL----
K
M
L
V
A
V
K
A
L
K
----
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPDAKLLAGG
E
D
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
-
I
--
Y
S
T
D
Y
Y
R
V
G
-------
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
75.71
34%
-119
- C1 -
-
4QD6
2
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
-----
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
--
T
----------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.63
32%
-11
- C1 -
-
4PMM
2
A:
[4-284]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LL---
D
K
M
L
V
A
V
K
A
L
K
---
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPDAKLLAGG
E
D
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
--
Y
S
T
D
Y
Y
R
V
G
---
G
R
--
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
75.37
34%
-25
- C1 -
-
3EKK
1
A:
[14-287]
----------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
--------
E
L
G
Q
G
S
F
G
M
V
Y
E
G
NAR
D
I
I
---
K
---
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
----
G
-
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
---
R
S
LRP--
E
----------
A
E
N
-
N
----
P
G
R
P
P
P
T
L
QE
M
I
----
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
---
D
F
T
V
K
I
G
D
F
-------------------------
L
L
P
V
R
W
M
A
P
E
---
S
L
K
D
G
V
F
T
T
S
----
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-------
M
D
G
---
G
Y
L
D
Q
P
-
D
N
CP
E
R
V
T
D
L
M
R
M
C
W
Q
F
-
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
74.70
33%
-45
- C1 -
-
4AOJ
1
NTRK1_HUMAN
B:
[37-317]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP---
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPD-----------------
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
--------------------------
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
74.46
34%
-133
- C1 -
-
4PPC
2
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
---------------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
HHSearch
74.27
30%
-33
- C1 -
-
3BKB
7
A:
[111-374]
-----------------------------------------------------------------------------------------------------------------------------------
L
N
H
E
D
L
V
L
G
E
--------
Q
I
G
R
G
N
F
G
E
V
F
S
G
---
R
L
R
A--
D
---
N
T
L
V
A
---
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
H
P
N
I
V
R
L
I
G
V
C
T
--
Q
----
K
-
Q
P
I
-
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
---
R
T
-----
E
----------
G
A
---------
R
L
R
V
K
T
--
L
L
----
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
---
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
--
A
D
G
V
Y
A
A
S
G
---
G
L
--
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
-------
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
-
E
K
G
-
G
R
L
P
------
C
P
E
L
-
C
P
--
D
A
V
F
R
L
M
E
Q
C
W
A
Y
-
E
-
P
G
Q
R
P
S
-
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
73.69
31%
-52
- C1 -
-
3AOX
5
A:
[37-307]
---------------------------------------------------------------------------------------------------------------------------
S
I
S
D
L
K
-
E
V
P
R
K
N
I
T
L
I
R
--------
G
L
G
----
G
E
V
Y
E
G
---
Q
V
----------
S
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
F
L
M
E
A
L
I
I
S
K
F
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
----
S
-
L
P
R
-
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
---
R
E
-----
T
----------
R
P
R
P
S
----
Q
P
S
S
L
A
M
L
D-
L
L
----
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
PGP
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--
Y
R
A
----------
C
--
A
M
L
P
V
K
W
M
P
P
E
---
A
F
M
E
G
I
F
T
S
K
----
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
G
G
R
M
D
P
P
K
----
N
C
P
G
P
-
V
------
Y
R
I
M
T
Q
C
W
-
Q
H
Q
-
P
E
D
R
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
73.61
34%
-122
- C1 -
-
4QD6
2
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
------
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
M
--
T
----------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.32
32%
-6
- C1 -
-
4PMS
1
A:
[4-284]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LL---
D
K
M
L
V
A
V
K
A
L
K
---
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPDAKLLAGG
E
D
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
--
Y
S
T
D
Y
Y
R
V
-----
R
--
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
73.16
34%
-131
- C1 -
-
4PPA
2
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
-------
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
72.40
34%
-130
- C1 -
-
4PPB
2
ITK_HUMAN
A:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
-------
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
72.20
32%
-58
- C1 -
-
5I8A
1
A:
[7-281]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
---
G
K
V
F
L
A
---
E
C
H
---
N
------
K
M
L
V
A
V
K
A
L
K
--------
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPDAKLLAGG
E
D
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
-
S
R
D
I
---
S
T
D
Y
Y
R
V
--------
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
-
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
72.16
34%
-126
- C1 -
-
4PPA
2
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
-------
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Fugue
72.09
30%
22
- C1 -
-
1IR3
1
A:
[4-306]
----------------------------------------------------------------------------------------------------------------------
S
S
V
F
V
P
---
D
E
W
E
V
S
R
E
K
I
T
L
L
R
--------
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
R
DII
K
---
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
-----G
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
---
R
S
LRPEA
E
----------
N
N
P
-
G
----
R
P
P
P
T
L
Q
E
--
M
I
----
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
--
R
DI
E
T
D
R
K
G
G
K
G
--------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
-------
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
-
E
Q
V
L
K
F
V
M
D
-
G
G
Y
L
D
Q
---
P
D
---
N
-
C
P
--
E
R
V
T
D
L
M
R
M
C
W
Q
F
-
N
-
P
K
M
R
P
T
-
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
72.02
34%
-127
- C1 -
-
4MF0
2
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
---
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
----
M
S
E
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
---------------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
71.86
32%
-22
- C1 -
-
5JFS
1
A:
[9-296]
-----------------------------------------------------------------------------------------------------------------------------------
V
P
R
G
S
V
H
H
I
K
RRDIVLKW
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GP----------
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
-------------------------
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
-
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
71.75
32%
-20
- C1 -
-
5JFV
1
A:
[9-296]
-----------------------------------------------------------------------------------------------------------------------------------
V
P
R
G
S
V
H
H
I
K
RRDIVLKW
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GP----------
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
-------------------------
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
-
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.73
32%
-26
- C1 -
-
4YNE
2
A:
[11-291]
----------------------------------------------------------------------------------------------------------------------------------
H
I
K
R
R
D
I
V
L
K
W
--------
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP--
D
K
M
L
V
A
V
K
A
L
K
E
-----
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GPDAKLLAGG
E
D
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
M
-------
S
T
D
Y
Y
-------
R
--
T
M
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
Q
R
-
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
71.19
34%
-119
- C1 -
-
4PPB
2
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
Q
F
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
-------
E
D
--
F
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
--
E
----
Q
-
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
F
G
--------------------------
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
70.82
32%
-15
- C1 -
-
5JFW
1
A:
[9-296]
-----------------------------------------------------------------------------------------------------------------------------------
V
P
R
G
S
V
H
H
I
K
RRDIVLKW
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GP----------
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
-------------------------
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
-
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
70.76
34%
-125
- C1 -
-
4PPC
2
B:
[9-259]
----------------------------------------------------------------------------------------------------------------------------------------
L
T
F
V
Q
--------
E
I
G
S
G
--
G
L
V
H
L
G
---
Y
W
L
---
N
---
K
D
K
V
A
---
I
K
T
I
------------
I
E
E
A
E
V
M
M
K
L
S
H
P
K
L
V
Q
L
Y
G
V
C
L
---------
A
P
I
-
C
L
V
F
E
F
M
E
H
G
C
L
S
D
Y
L
---
R
T
-----
Q
-------------------
R
G
L
F
A
A
E
T
--
L
L
----
G
M
C
L
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
---
N
Q
V
I
K
V
S
D
---------------------------
F
P
V
K
W
A
S
P
E
-
V
F
S
F
------
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
--
S
T
G
F
R
L
Y
K
---
P
R
L
A
S
T
-
H
V
-----
Y
Q
I
M
N
H
C
W
-
K
E
R
-
P
E
D
R
P
A
-
F
S
R
L
L
R
Q
L
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
70.30
32%
-14
- C1 -
-
5JFX
1
A:
[9-296]
-----------------------------------------------------------------------------------------------------------------------------------
V
P
R
G
S
V
H
H
I
K
RRDIVLKW
E
L
G
E
G
A
F
G
K
V
F
L
A
---
E
C
H
---
N
LLP
E
Q
D
K
M
L
V
A
V
K
A
L
K
E
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
Q
H
Q
H
I
V
R
F
F
G
V
C
T
--
E
----
G
-
R
P
L
-
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
---
R
S
-----
H
GP----------
V
-
A
----
P
G
P
L
G
L
G
Q
--
L
L
----
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
---
G
L
V
V
K
I
G
D
F
G
-------------------------
L
P
I
R
W
M
P
P
E
-------
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
ACP
P
E
V
-----------
Y
A
I
M
R
G
C
W
-
Q
R
E
-
P
Q
Q
R
H
S
-
I
K
D
V
H
A
R
L
Q
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
68.68
34%
-0
- C1 -
-
1IR3
1
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
--------
E
L
G
Q
G
S
F
G
M
V
Y
E
G
NAR
D
I
I
---
K
---
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
----
G
-
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
---
R
S
LRP--
E
----------
A
E
N
-
N
----
P
G
R
P
P
P
T
L
QE
M
I
----
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
--------
I
E
T
D
RKG
G
K
--
G
L
L
P
V
R
W
M
A
P
E
---
S
L
K
D
G
V
F
T
T
S
----
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-------
M
D
G
---
G
Y
L
D
Q
P
-
D
N
CP
E
R
V
T
D
L
M
R
M
C
W
Q
F
-
N
-
P
K
M
R
P
T
-
F
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
67.75
34%
-3
- C1 -
-
1RQQ
1
INSR_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
--------
E
L
G
Q
G
S
F
G
M
V
Y
E
G
NAR
D
I
I
---
K
---
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
----
G
-
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
---
R
S
LRP--
E
----------
A
E
N
-
N
----
P
G
R
P
P
P
T
L
QE
M
I
----
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
--------
I
E
T
D
RKG
G
K
--
G
L
L
P
V
R
W
M
A
P
E
---
S
L
K
D
G
V
F
T
T
S
----
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-------
M
D
G
---
G
Y
L
D
Q
P
-
D
N
CP
E
R
V
T
D
L
M
R
M
C
W
Q
F
-
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
67.75
34%
1
- C1 -
-
1RQQ
1
B:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
--------
E
L
G
Q
G
S
F
G
M
V
Y
E
G
NAR
D
I
I
---
K
---
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
----
G
-
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
---
R
S
LRP--
E
----------
A
E
N
-
N
----
P
G
R
P
P
P
T
L
QE
M
I
----
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
--------
I
E
T
D
RKG
G
K
--
G
L
L
P
V
R
W
M
A
P
E
---
S
L
K
D
G
V
F
T
T
S
----
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-------
M
D
G
---
G
Y
L
D
Q
P
-
D
N
CP
E
R
V
T
D
L
M
R
M
C
W
Q
F
-
N
-
P
N
M
R
P
T
-
F
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
67.60
31%
-57
- C1 -
-
3F66
3
B:
[27-286]
----------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
--------
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
L
--------
K
K
I
-
H
C
A
V
K
S
L
N
------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
R--------
S
P
--
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
-----
E
----------
T
H
---------
N
P
T
V
K
D
--
L
I
----
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
---
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
--
Y
D
K
E
Y
Y
S
---------
A
K
L
P
V
K
W
M
A
L
E
-------
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
----------
R
L
L
Q
P
E
Y
C
P-
D
P
L
Y
E
V
M
L
K
C
W
-
H
P
K
-
A
E
M
R
P
S
F
S
E
L
V
S
R
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
67.28
34%
-2
- C1 -
-
1GAG
1
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
--------
E
L
G
Q
G
S
F
G
M
V
Y
E
G
NAR
D
I
I
---
K
---
G
E
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
----
G
-
Q
P
T
-
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
---
R
S
LRP--
E
----------
A
E
N
-
N
----
P
G
R
P
P
P
T
L
QE
M
I
----
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
---
D
F
T
V
K
I
G
D
F
G
M
T
R
D
--------
I
E
T
D
RKG
G
K
--
G
L
L
P
V
R
W
M
A
P
E
---
S
L
K
D
G
V
F
T
T
S
----
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
-------
M
D
G
---
G
Y
L
D
Q
P
-
D
N
CP
E
R
V
T
D
L
M
R
M
C
W
Q
F
-
N
-
P
K
M
R
P
T
-
F
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
66.41
31%
-29
- C1 -
-
3F66
4
MET_HUMAN
A:
[27-286]
----------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
--------
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
L
---------
K
I
-
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
RS
E
----
G
-
S
P
--
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
-----
E
----------
T
H
---------
N
P
T
V
K
D
--
L
I
----
G
F
G
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
---
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
--
Y
D
K
E
Y
Y
S
V
--------
A
K
L
P
V
K
W
M
A
L
E
-------
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
----------
R
L
L
Q
P
E
Y
C
P-
D
P
L
Y
E
V
M
L
K
C
W
-
H
P
K
-
A
E
M
R
P
S
F
S
E
L
V
S
R
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
64.78
31%
-15
- C1 -
-
3DKC
1
A:
[33-292]
----------------------------------------------------------------------------------------------------------------------------------------
V
H
F
N
E
--------
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
L
---
D
ND-
G
K
K
I
-
H
C
A
V
K
S
L
N
R
I
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
H
P
N
V
L
S
L
L
G
I
C
L
RS
E
----
G
-
S
P
--
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
---
R
N
-----
E
----------
T
H
---------
N
P
T
V
K
D
--
L
I
----
G
F
G
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
---
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
--
Y
D
K
E
F
D
S
V
H
---
N
K
TG
A
K
L
P
V
K
W
M
A
L
E
-------
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
----------
R
L
L
Q
P
E
Y
C
P-
D
P
L
Y
E
V
M
L
K
C
W
-
H
P
K
-
A
E
M
R
P
S
F
S
E
L
V
S
R
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
47.88
31%
-23
- C1 -
-
5U6C
1
B:
[40-307]
------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
E
F
G
-
V
M
E
G
---
N
L
K
---
Q
ED-
G
T
S
L
-
K
V
A
V
K
T
M
K
L
--------
E
F
L
S
E
A
A
C
M
K
D
F
S
H
P
N
V
M
R
L
L
G
V
C
I
--
E
MSSQ
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
LYS
R
L
-----
E
----------
T
G
P
-
K
----
H
I
P
L
Q
T
L
L
--------
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
---
D
M
T
V
C
V
A
D
F
G
L
--------------------------
V
K
W
I
A
I
E
---
S
L
A
D
R
V
Y
T
S
K
----
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
---
D
C
L
--------
D
E
L
Y
E
I
M
Y
S
C
W
-
R
-
T
D
P
L
D
R
P
T
--------
F
S
V
L
R
L
Q
L
E
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------