@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MARK3_HUMAN: (2020-09-15 )
MSTRTPLPTVNERDTENHTSHGDGRQEVTSRTSRSGARCRNSIASCADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLIMEYASGGEVFDYLVAHGRMKEKEARSKFRQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGGKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKRFLVLNPIKRGTLEQIMKDRWINAGHEEDELKPFVEPELDISDQKRIDIMVGMGYSQEEIQESLSKMKYDEITATYLLLGRKSSELDASDSSSSSNLSLAKVRPSSDLNNSTGQSPHHKVQRSVFSSQKQRRYSDHAGPAIPSVVAYPKRSQTSTADSDLKEDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRRNTYVCSERTTADRHSVIQNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATPLSQTRSRGSTNLFSKLTSKLTRRNMSFRFIKRLPTEYERNGRYEGSSRNVSAEQKDENKEAKPRSLRFTWSMKTTSSMDPGDMMREIRKVLDANNCDYEQRERFLLFCVHGDGHAENLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
Atome Classification :
(426 SA)
.........10........20......-..30........40........50.----.......60........70.....-...80........90--.-.--.-....-.-.100--.......-..110.......120-.......130.......140......--.150--........160.......170.......180...---.---..---.---190--........200-.....-...---.210--........220.......230---.........240......-.250..--.....260......-.270.--.--..----.------....280.......290...-....300..----...----.-----.---310.......320.------......330.......340.......350....--...360.......370.......380.......390.......400-.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSTRTPLPTVNERDTENHTSHGD
G
R
Q
E
-
V
T
S
RTSRS
G
A
R
C
R
N
S
I
A
S
C
ADEQPH----IG
N
Y
R
L
L
K
T
IGKGNF
A
K
V
K
L
A
R
H
I
-LTG
R
E
V
A
I
K
I
I
DKT---Q-L--
N
-
P
T
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
I
LNHP
N
I
V
K
L
F
E
V
I
-ETE
K
T
L
Y
L
I
M
E
YASG
G
E
V
F
D
Y
L
V
AHG--RM
K
---
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
DLKAE
N
L
L
---L---DA---D---M
N
---
I
K
I
A
DFGFS---N
E
F
TV-GGK---LDT---FCGSPPYAA
P
E
LFQGKKYD-----GPEV
D
V
W
S
L
G
V
I
L
Y
T
L
VS-GSLPFD--
G
Q
N
L
K
E
L
R
E
R
V
LRG-K
Y
--
R
--
I
--
P
F
----
Y
------MST
D
C
E
N
L
L
K
R
F
L
V
LNPIK
R
-
G
T
L
E
Q
I
M
K
D
----RWI----N-----A---GH
E
E
D
ELKPFVEPE------LDISDQ
K
R
I
D
I
M
V
GMGY
S
Q
E
E
I
Q
E
S
L
S
KM
K
Y
D
E
--
I
T
A
T
Y
L
L
LGRKSSELDASDSSSSSN
L
S
L
A
K
VRPSSDLNNSTGQS
P
H
-
H
K
V
Q
R
S
V
F
S
S
Q
K
Q
R
RYSDHAGPAIP
S
V
VAYPKRSQTSTAD
S
D
L
K
EDGISSRKSSGSAVGGKGIAPASPMLGNASNPNKADIPERKKSSTVPSSNTASGGMTRR
N
T
Y
V
CSERTT
A
D
R
H
S
V
I
QNGKENSTIPDQRTPVASTHSISSAATPDRIRFPRGTASRSTFHGQPRERRTATYNGPPASPSLSHEATP
L
S
Q
TRSRGS
T
N
L
F
S
K
L
T
S
K
L
T
RRN
M
S
F
R
F
I
K
RL
P
T
E
Y
ERNGRYEGSSRNVSAEQKDENKEAKP
R
S
L
R
F
T
W
SMKTTSSM
D
P
G
D
M
M
R
E
I
R
K
V
LDANNC
D
Y
E
Q
R
E
R
F
L
L
F
C
VHGDG
H
A
E
N
L
V
Q
W
E
M
E
V
CKLPRLSLN
G
V
R
F
K
RISGT
S
I
A
F
K
N
I
A
S
K
I
A
N
ELKL
1
PsiBlast_PDB
92.08
99%
-109
- C- -
-
3FE3
-
MARK3_HUMAN
A:
[50-366]
--------------------------------------------------
Q
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
R
E
V
A
I
K
I
I
D
K
T
---
Q
-
L
--
N
-
P
T
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
T
V
-
G
G
K
---
L
D
A
---
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
I
----
N
-----
A
---
G
H
E
E
D
E
L
K
P
F
V
E
P
E
------
L
D
I
S
D
Q
K
R
I
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
--
I
T
A
T
Y
L
L
L
G
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
91.69
86%
-110
- C2 -
-
6C9D
-
MARK1_HUMAN
A:
[16-445]
-------------------------------------------------
E
Q
P
H
----
I
G
N
Y
R
L
Q
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
V
-
L
T
G
R
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
P
T
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
Y
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
G
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
T
V
-
G
N
K
---
L
D
E
---
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
L
L
V
L
N
P
I
K
R
-
G
S
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
E
E
E
L
K
P
Y
T
E
P
D
------
P
D
F
N
D
T
K
R
I
D
I
M
V
T
M
G
F
A
R
D
E
I
N
D
A
L
I
N
Q
K
Y
D
E
--
V
M
A
T
Y
I
L
L
G
R
K
P
P
E
F
E
G
G
E
S
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
561
HHSearch
91.68
100%
-108
- C2 -
-
2QNJ
-
MARK3_HUMAN
B:
[50-367]
--------------------------------------------------
Q
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
R
E
V
A
I
K
I
I
D
K
T
---
Q
-
L
--
N
-
P
T
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
T
----
K
---
L
D
T
---
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
I
----
N
-----
A
---
G
H
E
E
D
E
L
K
P
F
V
E
P
E
------
L
D
I
S
D
Q
K
R
I
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
--
I
T
A
T
Y
L
L
L
G
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
91.14
99%
-104
- C2 -
-
2QNJ
-
MARK3_HUMAN
A:
[44-366]
--------------------------------------------
A
M
G
S
-
E
Q
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
R
E
V
A
I
K
I
I
D
K
T
---
Q
-
L
--
N
-
P
T
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
T
---------
D
T
---
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
I
----
N
-----
A
---
G
H
E
E
D
E
L
K
P
F
V
E
P
E
------
L
D
I
S
D
Q
K
R
I
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
--
I
T
A
T
Y
L
L
L
G
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
560
HHSearch
89.89
99%
-109
- C- -
-
3FE3
-
MARK3_HUMAN
B:
[50-366]
--------------------------------------------------
Q
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
R
E
V
A
I
K
I
I
D
K
T
---
Q
-
L
--
N
-
P
T
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
T
V
-
G
G
K
---
L
D
A
---
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
I
----
N
-----
A
---
G
H
E
E
D
E
L
K
P
F
V
E
P
E
------
L
D
I
S
D
Q
K
R
I
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
--
I
T
A
T
Y
L
L
L
G
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
85.80
87%
-118
- C2 -
-
3IEC
-
MARK2_HUMAN
A:
[5-318]
----------------------------------------------------
H
----
I
G
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
W
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
T
F
-
G
N
K
---
L
D
T
---
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
85.41
88%
-97
- C2 -
-
2HAK
-
MARK1_HUMAN
A:
[48-364]
---------------------------------------------------
P
H
----
I
G
N
Y
R
L
Q
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
V
-
L
T
G
R
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
P
T
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
Y
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
G
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
T
V
---------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
L
L
V
L
N
P
I
K
R
-
G
S
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
E
E
E
L
K
P
Y
T
E
P
D
------
P
D
F
N
D
T
K
R
I
D
I
M
V
T
M
G
F
A
R
D
E
I
N
D
A
L
I
N
Q
K
Y
D
E
--
V
M
A
T
Y
I
L
L
G
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
85.28
88%
-115
- C2 -
-
5EAK
1
MARK2_HUMAN
B:
[15-327]
----------------------------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
-----------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
84.35
86%
-120
- C2 -
-
5ES1
1
MARK4_HUMAN
A:
[12-328]
---------------------------------------------------
P
H
----
V
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
R
E
V
A
I
K
I
I
D
K
T
---
Q
-
L
--
N
-
P
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
G
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
E
---
A
N
---
I
K
I
A
D
F
G
F
S
---
N
--------------------
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
H
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
V
--
P
F
----
Y
------
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
-
C
T
L
E
Q
I
M
K
D
----
K
W
I
----
N
-----
I
---
G
Y
E
G
E
E
L
K
P
Y
T
E
P
E
------
E
D
F
G
D
T
K
R
I
E
V
M
V
G
M
G
Y
T
R
E
E
I
K
E
S
L
T
S
Q
K
Y
N
E
--
V
T
A
T
Y
L
L
L
G
R
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
84.24
87%
-118
- C2 -
-
5KZ8
1
MARK2_HUMAN
A:
[30-345]
---------------------------------------------------
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
------------------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
83.80
88%
-118
- C2 -
-
5KZ8
1
MARK2_HUMAN
B:
[30-345]
---------------------------------------------------
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
--------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
83.13
87%
-119
- C- -
-
2R0I
-
MARK2_RAT
A:
[48-363]
---------------------------------------------------
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
--------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
A
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
83.04
87%
-122
- C2 -
-
1ZMW
-
MARK2_RAT
A:
[49-363]
----------------------------------------------------
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
--------------------
L
D
A
---
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
82.52
87%
-105
- C2 -
-
5EAK
1
MARK2_HUMAN
A:
[11-326]
--------------------------------------------------
Q
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
82.30
84%
-117
- C2 -
-
1Y8G
-
MARK2_RAT
A:
[49-363]
----------------------------------------------------
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
--------------------
L
D
A
---
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
81.82
87%
-125
- C2 -
-
1ZMV
-
MARK2_RAT
A:
[51-363]
----------------------------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
R
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
----------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.51
87%
-125
- C2 -
-
5KZ7
1
MARK2_HUMAN
A:
[30-345]
---------------------------------------------------
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
--------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
----
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.99
87%
-116
- C2 -
-
1ZMU
-
MARK2_RAT
A:
[51-363]
----------------------------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
----------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
80.71
88%
-122
- C2 -
-
5KZ7
1
MARK2_HUMAN
B:
[30-345]
---------------------------------------------------
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
S
S
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
--------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
----
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-
G
T
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
D
D
E
L
K
P
Y
V
E
P
L
------
P
D
Y
K
D
P
R
R
T
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
--
V
M
A
T
Y
L
L
L
G
Y
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
559
HHSearch
79.04
94%
-116
- C2 -
-
6C9D
-
MARK1_HUMAN
A:
[16-299]
-------------------------------------------------
E
Q
P
H
----
I
G
N
Y
R
L
Q
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
V
-
L
T
G
R
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
-
P
T
S
L
-
Q
-
K
L
----
F
R
E
V
R
I
M
-
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
Y
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
G
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
T
V
-
G
N
K
---
L
D
E
---
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
--
I
--
P
F
----
Y
------
M
S
T
D
C
E
N
L
L
K
K
L
L
V
L
N
P
I
K
R
-
G
S
L
E
Q
I
M
K
D
----
R
W
M
----
N
-----
V
---
G
H
E
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
564
HHSearch
71.33
41%
-118
- C2 -
-
5TVT
1
MELK_HUMAN
A:
[7-327]
---------------------------------------------------
E
L
----
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
----
G
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
----
M
-----
Q
---
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
------
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
--
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
562
HHSearch
69.15
41%
-116
- C2 -
-
5K00
1
MELK_HUMAN
A:
[6-326]
----------------------------------------------------
L
----
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
----
G
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
P
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
----
M
-----
Q
---
D
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
------
I
H
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
--
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
65.68
42%
-125
- C2 -
-
4UMT
2
MELK_HUMAN
A:
[31-332]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
-----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
T
A
A
A
L
V
A
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
65.59
42%
-115
- C2 -
-
5TWL
1
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
-----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
64.92
41%
-127
- C2 -
-
4UMR
1
MELK_HUMAN
A:
[31-332]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
-----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
T
A
A
A
L
V
A
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
64.64
39%
-37
- C2 -
-
6C9H
3
AAPK1_HUMAN
A:
[13-472]
---------------------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
T
---
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
--------------
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------
F
Y
L
A
T
S
P
----------
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
A
R
H
T
L
D
E
L
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
64.61
42%
-110
- C2 -
-
5TVT
1
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
64.56
42%
-121
- C2 -
-
4UMU
1
MELK_HUMAN
A:
[31-332]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
-----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
T
A
A
A
L
V
A
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
64.51
41%
-103
- C2 -
-
6GVX
3
MELK_HUMAN
A:
[2-316]
-------------------------------------------
L
G
S
M
K
D
Y
D
E
L
----
L
K
Y
Y
E
L
H
E
T
I
G
T
--
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
--------
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-
P
K
-
G
N
K
----------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
-------
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
63.97
41%
-124
- C2 -
-
4UMQ
1
MELK_HUMAN
A:
[31-332]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
-----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
T
A
A
A
L
V
A
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
63.90
42%
-118
- C2 -
-
4BKY
1
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
------
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
63.73
42%
-116
- C2 -
-
5M5A
1
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
63.46
42%
-115
- C2 -
-
5MAH
2
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
63.38
42%
-112
- C2 -
-
5IH9
1
MELK_HUMAN
A:
[10-311]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
---------
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
63.17
45%
-138
- C2 -
-
4BFM
1
MELK_MOUSE
A:
[11-263]
------------------------------------------------------------
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
A
-
L
--
G
--
S
D
L
-
P
-
R
V
----
K
T
E
I
D
A
L
-
K
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
N
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-----------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
----------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
E
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
R
N
L
L
N
H
----
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
63.01
42%
-123
- C2 -
-
5IHC
1
MELK_HUMAN
A:
[10-311]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
--------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
62.96
42%
-125
- C2 -
-
5TWZ
1
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
-------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
62.95
42%
-114
- C2 -
-
5MAG
3
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
------
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
62.73
42%
-114
- C2 -
-
5IH8
1
MELK_HUMAN
A:
[10-311]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
--------
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
62.56
41%
-100
- C2 -
-
6GVX
3
MELK_HUMAN
B:
[2-316]
-------------------------------------------
L
G
S
M
K
D
Y
D
E
L
----
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-------
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-
P
----------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
---------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
62.55
45%
-137
- C2 -
-
4CQG
1
MELK_MOUSE
A:
[11-263]
------------------------------------------------------------
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
A
-
L
--
G
--
S
D
L
-
P
-
R
V
----
K
T
E
I
D
A
L
-
K
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
N
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-----------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
----------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
E
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
R
N
L
L
N
H
----
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
62.44
42%
-121
- C2 -
-
5TWY
1
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
--------
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
-----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
62.42
42%
-109
- C2 -
-
5K00
1
MELK_HUMAN
A:
[10-311]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-
P
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
62.42
42%
-119
- C2 -
-
4BKZ
1
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
-------
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
--------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
---------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
62.39
42%
-120
- C2 -
-
5MAI
2
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
--
S
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
---------------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
--
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
62.34
42%
-116
- C2 -
-
4BL1
1
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
-------
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
62.24
42%
-110
- C2 -
-
5MAF
2
MELK_HUMAN
A:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
------
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
61.91
42%
-118
- C2 -
-
5IHA
1
MELK_HUMAN
A:
[10-311]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
----
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
-----------
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
60.73
42%
-125
- C2 -
-
5TX3
2
MELK_HUMAN
A:
[15-316]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
------------------
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
59.90
39%
-77
- C2 -
-
6AYW
2
KCC2D_HUMAN
B:
[15-273]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-
I
T
A
S
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
59.74
39%
-88
- C2 -
-
3BHH
1
KCC2B_HUMAN
B:
[6-264]
------------------------------------------------------------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
-
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
---
C
K
GAA
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
-----
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
-
I
T
A
H
E
A
L
K
H
----
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
59.72
42%
-120
- C2 -
-
5TX3
2
MELK_HUMAN
B:
[15-316]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
-----
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
------------------------
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
---------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
---
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
59.65
39%
-79
- C2 -
-
5VLO
2
KCC2D_HUMAN
A:
[15-273]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
---
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-
I
T
A
S
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
59.28
39%
-87
- C2 -
-
3BHH
1
KCC2B_HUMAN
A:
[6-264]
------------------------------------------------------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
-
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
---
C
K
GAA
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
-----
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
-
I
T
A
H
E
A
L
K
H
----
P
W
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
58.81
39%
-73
- C2 -
-
5VLO
2
KCC2D_HUMAN
B:
[15-273]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-
I
T
A
S
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
58.76
39%
-74
- C2 -
-
2VN9
2
KCC2D_HUMAN
A:
[6-264]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-
I
T
A
S
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
58.63
42%
-118
- C2 -
-
5TWY
1
MELK_HUMAN
B:
[12-313]
------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
------------
D
L
-
P
-
R
I
----
K
T
E
I
E
A
L
-
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
L
S
---
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
-------------------------
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
--
V
--
P
K
----
W
------
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-
I
S
M
K
N
L
L
N
H
----
P
W
I
MQDY
N
-----
Y
---
P
V
E
W
Q
S
K
N
P
F
I
H
----------
L
D
D
D
C
V
T
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
58.36
39%
-73
- C2 -
-
2VN9
1
KCC2D_HUMAN
B:
[6-264]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-
I
T
A
S
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
58.35
39%
-77
- C2 -
-
6AYW
2
KCC2D_HUMAN
A:
[15-273]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-
I
T
A
S
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
58.10
39%
-67
- C2 -
-
5FG8
3
KCC2A_DROME
A:
[15-274]
-----------------------------------------------------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
-
S
T
G
F
E
F
A
A
K
I
I
N
T
K
---
K
-
L
--
T
-
A
R
D
F
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
K
L
H
H
P
N
I
V
R
L
H
D
S
I
-
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
F
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
---
A
K
GAA
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
H
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
------
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
S
Q
I
K
A
G
-
A
Y
--
D
--
Y
--
P
S
PEWD
T
------
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
-
I
T
A
A
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
57.98
39%
-77
- C2 -
-
2WEL
7
KCC2D_HUMAN
A:
[6-268]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-
I
T
A
S
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
57.90
38%
-76
- C2 -
-
3SOA
1
KCC2A_HUMAN
A:
[13-272]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
-
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
---
A
S
---
K
---
L
K
GAA
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
E
G
E
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
-
I
T
A
A
E
A
L
K
H
----
P
W
I
----
S
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
57.89
39%
-73
- C2 -
-
6BAB
2
KCC2D_MOUSE
B:
[15-273]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
----
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-
I
T
A
S
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
57.79
39%
-71
- C2 -
-
6BAB
1
KCC2D_MOUSE
D:
[15-273]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-
I
T
A
S
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
57.78
39%
-74
- C2 -
-
6BAB
2
KCC2D_MOUSE
A:
[15-273]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-
I
T
A
S
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
57.66
38%
-66
- C2 -
-
5HU3
1
KCC2A_DROME
A:
[15-274]
-----------------------------------------------------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
-
S
T
G
F
E
F
A
A
K
I
I
N
T
K
---
K
-
L
--
T
-
A
R
D
F
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
K
L
H
H
P
N
I
V
R
L
H
D
S
I
-
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
F
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
---
A
S
---
K
---
A
K
GAA
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
H
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
------
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
S
Q
I
K
A
G
-
A
Y
--
D
--
Y
--
P
S
PEWD
T
------
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
-
I
T
A
A
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
57.11
39%
-70
- C2 -
-
6BAB
2
KCC2D_MOUSE
C:
[15-273]
------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
-----
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
-
A
R
D
H
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
Q
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
--
F
--
P
S
PEWD
T
------
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-
I
T
A
S
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
56.99
39%
-66
- C2 -
-
5H9B
2
KCC2A_DROME
A:
[15-274]
-----------------------------------------------------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
-
S
T
G
F
E
F
A
A
K
I
I
N
T
K
---
K
-
L
--
T
-
A
R
D
F
-
Q
-
K
L
----
E
R
E
A
R
I
C
-
R
K
L
H
H
P
N
I
V
R
L
H
D
S
I
-
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
F
Y
S
---
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
---
A
K
GAA
V
K
L
A
D
F
G
L
A
---
I
E
--
V
-
Q
G
D
---
H
Q
A
WFG
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
------
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
S
Q
I
K
A
G
-
A
Y
--
D
--
Y
--
P
S
PEWD
T
------
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
-
I
T
A
A
E
A
L
K
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
56.47
46%
-49
- C2 -
-
3AQV
1
AAPK2_HUMAN
A:
[5-276]
------------------------------------------------
D
G
R
V
K
----
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
K
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
--
R
V
E
---
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
---------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
E
H
V
P
T
L
F
K
K
I
R
G
G
-
V
F
--
Y
--
I
--
P
E
----
Y
------
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
S
Y
L
F
P
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
56.40
34%
-132
- C2 -
-
3W18
1
AURKA_HUMAN
B:
[2-260]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
-------------------
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
56.04
34%
-134
- C2 -
-
3W18
1
AURKA_HUMAN
A:
[2-260]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
--
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
------------
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
55.36
37%
-37
- C2 -
-
2UZT
1
KAPCA_BOVIN
A:
[20-276]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
---
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
55.11
39%
-68
- C2 -
-
3IGO
8
?
A:
[24-295]
------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
-
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
-
A
--
K
-
N
K
-
T
-
S
-
T
I
----
L
R
E
V
E
L
L
-
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
-
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
--
R
F
S
---
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
-
N
T
-------------
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
-
K
Y
--
A
FD
L
--
P
Q
----
W
RT----
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-
I
T
A
T
Q
C
L
E
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
54.68
38%
-85
- C2 -
-
6T6F
1
?
B:
[16-287]
------------------------------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
-
A
T
G
K
L
F
A
V
K
C
I
P
K
K
---
A
-
L
--
K
-
G
K
E
--
S
-
S
I
----
E
N
E
I
A
V
L
-
R
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
-
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
---
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
E
---
E
---
S
K
---
I
M
I
S
D
F
G
---------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-
G
Y
P
P
F
Y
--
D
E
N
D
S
K
L
F
E
Q
I
L
K
A
-
E
Y
--
E
--
F
DS
P
Y
----
W
DD----
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
-
Y
T
C
E
Q
A
A
R
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
54.59
34%
-21
- C2 -
-
2OJF
1
KAPCA_BOVIN
E:
[35-342]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
---
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
---
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
54.58
34%
-15
- C2 -
-
2F7X
1
KAPCA_BOVIN
E:
[35-342]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
---
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
---
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
54.56
40%
-63
- C2 -
-
4IEB
1
?
A:
[51-310]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
-----
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
-----
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
54.46
37%
-69
- C2 -
-
2CGW
1
CHK1_HUMAN
A:
[6-266]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
------
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
54.46
39%
-68
- C2 -
-
3MWU
1
?
A:
[24-300]
------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
-
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
-
A
--
K
-
N
K
D
T
-
S
-
T
I
----
L
R
E
V
E
L
L
-
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
-
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
--
R
F
S
---
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
-
N
-------
D
---
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
-
K
Y
--
A
FD
L
--
P
Q
----
W
RT----
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-
I
T
A
T
Q
C
L
E
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
54.31
37%
-66
- C2 -
-
2CGV
1
CHK1_HUMAN
A:
[6-266]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
54.30
34%
-16
- C2 -
-
2OH0
1
KAPCA_BOVIN
E:
[35-342]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
---
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
---
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
54.28
37%
-67
- C2 -
-
4HYI
4
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
------
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
54.18
37%
-65
- C2 -
-
1ZLT
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
54.17
34%
-44
- C2 -
-
4DHF
1
AURKA_HUMAN
B:
[8-265]
---------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
54.12
37%
-68
- C2 -
-
2BRG
1
CHK1_HUMAN
A:
[7-266]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-----------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
54.08
37%
-70
- C2 -
-
2CGU
1
CHK1_HUMAN
A:
[6-266]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
54.05
34%
-19
- C2 -
-
2F7Z
1
KAPCA_BOVIN
E:
[35-342]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
---
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
---
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
54.03
39%
-70
- C2 -
-
3NCG
1
?
A:
[24-317]
------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
-
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
-
A
--
K
-
N
K
D
T
-
S
-
T
I
----
L
R
E
V
E
L
L
-
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
-
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
--
R
F
S
---
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
-
N
T
-----------
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
-
K
Y
--
A
FD
L
--
P
Q
----
W
RT----
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-
I
T
A
T
Q
C
L
E
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
53.98
37%
-68
- C2 -
-
2BR1
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
53.95
34%
-51
- C2 -
-
2W1E
1
AURKA_HUMAN
A:
[7-265]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
53.94
37%
-72
- C2 -
-
4FSR
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
53.88
34%
-36
- C2 -
-
3H10
1
AURKA_HUMAN
A:
[1-262]
-----------------------------------------------
A
K
R
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
A
A
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
53.87
37%
-74
- C2 -
-
3OT3
1
CHK1_HUMAN
A:
[4-265]
----------------------------------------------------
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
------------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
53.86
37%
-66
- C2 -
-
4QYG
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
53.85
34%
-17
- C2 -
-
2F7E
1
KAPCA_BOVIN
E:
[35-342]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
---
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
---
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
K
G
P
G
D
T
S
N
F
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
53.71
35%
-46
- C2 -
-
2WTW
1
AURKA_HUMAN
A:
[10-267]
---------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
53.63
34%
-36
- C2 -
-
3H10
1
AURKA_HUMAN
B:
[2-262]
------------------------------------------------
K
R
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
A
A
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
53.66
37%
-69
- C2 -
-
2HY0
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
53.65
37%
-67
- C2 -
-
3NLB
1
CHK1_HUMAN
A:
[6-266]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
53.61
37%
-66
- C2 -
-
2C3K
1
CHK1_HUMAN
A:
[6-266]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
53.63
34%
-44
- C2 -
-
4JBQ
1
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
53.62
37%
-71
- C2 -
-
4RVM
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
53.58
39%
-70
- C2 -
-
4FG8
1
KCC1A_HUMAN
B:
[20-276]
------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
-
R
T
Q
K
L
V
A
I
K
C
I
A
K
-------------------------
N
E
I
A
V
L
-
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
-
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
---
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
---
S
K
---
I
M
I
S
D
F
G
-----------
G
S
V
---
L
S
T
---
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
-
E
Y
--
E
--
F
DS
P
Y
----
W
DD----
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
-
F
T
C
E
Q
A
L
Q
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
53.61
34%
-46
- C2 -
-
3FDN
1
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
A
----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
53.58
35%
-49
- C2 -
-
3D15
1
AURKA_MOUSE
A:
[8-266]
--------------------------------------------------
Q
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
-------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-
L
T
L
A
E
V
L
E
H
----
P
W
I
----
K
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
53.56
37%
-69
- C2 -
-
4QYG
1
CHK1_HUMAN
B:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
53.51
34%
-55
- C2 -
-
2W1D
1
AURKA_HUMAN
A:
[7-265]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
53.51
39%
-64
- C2 -
-
4Y5Q
1
?
A:
[24-300]
------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
-
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
-
A
--
K
-
N
K
D
T
-
S
-
T
I
----
L
R
E
V
E
L
L
-
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
-
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
--
R
F
S
---
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
-
N
T
------
D
---
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
-
K
Y
--
A
FD
L
--
P
Q
----
W
RT----
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-
I
T
A
T
Q
C
L
E
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
53.49
37%
-71
- C2 -
-
3TKI
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
53.50
35%
-49
- C2 -
-
3D14
1
AURKA_MOUSE
A:
[8-266]
--------------------------------------------------
Q
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-
L
T
L
A
E
V
L
E
H
----
P
W
I
----
K
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
53.49
34%
-43
- C2 -
-
6CPF
1
AURKA_HUMAN
A:
[10-267]
---------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
53.43
37%
-70
- C2 -
-
4RVK
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
53.42
37%
-67
- C2 -
-
2BRM
1
CHK1_HUMAN
A:
[7-266]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
53.44
35%
-51
- C2 -
-
3DJ7
1
AURKA_MOUSE
A:
[8-266]
--------------------------------------------------
Q
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-
L
T
L
A
E
V
L
E
H
----
P
W
I
----
K
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
53.43
37%
-69
- C2 -
-
4HYH
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
53.42
35%
-46
- C2 -
-
4DEA
4
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
53.40
34%
-42
- C2 -
-
4DHF
1
AURKA_HUMAN
A:
[8-265]
---------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
53.39
37%
-66
- C2 -
-
2HXL
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
53.36
37%
-67
- C2 -
-
2BRB
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
53.36
37%
-71
- C2 -
-
2BRO
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
53.31
37%
-29
- C2 -
-
2UZV
1
KAPCA_BOVIN
A:
[20-276]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
---
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
53.27
37%
-71
- C2 -
-
4FTI
3
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
------------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
53.30
35%
-46
- C2 -
-
3UO5
1
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
53.27
37%
-69
- C2 -
-
4QYH
1
CHK1_HUMAN
B:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
53.26
35%
-41
- C2 -
-
3UO6
3
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
53.25
37%
-70
- C2 -
-
4QYE
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
53.22
37%
-71
- C2 -
-
4QYH
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
53.21
37%
-69
- C2 -
-
2BRN
1
CHK1_HUMAN
A:
[6-266]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
53.20
37%
-71
- C2 -
-
1NVQ
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
53.18
37%
-69
- C2 -
-
2R0U
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
53.13
37%
-68
- C2 -
-
2C3J
1
CHK1_HUMAN
A:
[6-266]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
53.10
37%
-68
- C2 -
-
2XEY
1
CHK1_HUMAN
A:
[6-266]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
-------------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
53.10
35%
-42
- C2 -
-
3UP2
3
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
53.06
37%
-70
- C2 -
-
4FT0
2
CHK1_HUMAN
A:
[3-269]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
-------------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
53.09
37%
-71
- C2 -
-
2HOG
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
53.07
37%
-35
- C2 -
-
2UZW
1
KAPCA_BOVIN
E:
[20-276]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
---
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
53.06
34%
-43
- C2 -
-
4JBO
1
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
-
S
R
R
---
T
D
----
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
53.04
46%
-64
- C2 -
-
6BX6
1
AAPK2_HUMAN
A:
[10-274]
---------------------------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
K
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
--
R
V
E
---
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
--------------------------
N
Y
A
A
P
E
------
Y
A
-----
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
E
H
V
P
T
L
F
K
K
I
R
G
G
-
V
F
--
Y
--
I
--
P
E
----
Y
------
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
S
Y
L
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
53.03
34%
-44
- C2 -
-
5DNR
1
AURKA_HUMAN
A:
[8-266]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
-
S
R
R
---
T
-
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
52.96
37%
-74
- C2 -
-
5F4N
8
CHK1_HUMAN
A:
[5-266]
----------------------------------------------------
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
53.00
34%
-50
- C2 -
-
2XNG
1
AURKA_HUMAN
A:
[7-265]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
-----------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
52.99
39%
-85
- C2 -
-
4FG7
1
KCC1A_HUMAN
A:
[20-276]
------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
-
R
T
Q
K
L
V
A
I
K
C
I
A
-------------------
S
M
----
E
N
E
I
A
V
L
-
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
-
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
---
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
---
S
K
---
I
M
I
S
D
F
G
L
S
---
K
M
E
D
P
---------------
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
-
E
Y
--
E
--
F
DS
P
Y
----
W
DD----
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
-
F
T
C
E
Q
A
L
Q
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
52.98
37%
-64
- C2 -
-
2GDO
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
52.96
34%
-49
- C2 -
-
4BYI
1
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
52.93
35%
-45
- C2 -
-
3UOD
3
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
52.91
37%
-71
- C2 -
-
2C3L
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
---------
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
52.88
37%
-71
- C2 -
-
4FT7
4
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
52.87
38%
-45
- C2 -
-
2WEI
1
?
A:
[24-286]
------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
-
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
-
A
--
K
-
N
K
D
T
-
S
-
T
I
----
L
R
E
V
E
L
L
-
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
-
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
--
R
F
S
---
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
Q
Q
-
N
T
K
---
M
K
D
---
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
-
K
Y
--
A
FD
L
--
P
Q
----
W
RT----
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
-
I
T
A
T
Q
C
L
E
H
----
P
W
I
----
Q
-----
K
---
Y
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
52.85
37%
-73
- C2 -
-
3PA3
1
CHK1_HUMAN
A:
[4-265]
----------------------------------------------------
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
52.83
34%
-37
- C2 -
-
5G15
1
AURKA_HUMAN
A:
[6-264]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
52.82
34%
-55
- C2 -
-
4C3P
1
AURKA_HUMAN
A:
[6-264]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
52.81
42%
-20
- C2 -
-
4CZT
4
CIPKN_ARATH
D:
[10-277]
---------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
-
N
K
M
I
-
A
-
Q
I
----
K
R
E
I
S
T
M
-
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
G
L
---
L
H
T
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
--
C
--
P
P
----
W
------
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
---
G
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
52.79
37%
-64
- C2 -
-
2HXQ
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
52.78
37%
-73
- C2 -
-
4JIK
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
----------------
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
52.76
37%
-72
- C2 -
-
4FT9
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
------------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
52.75
34%
-50
- C2 -
-
5DR9
2
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
--------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
52.69
37%
-76
- C2 -
-
4FTU
4
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
52.65
37%
-71
- C2 -
-
1NVR
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
52.61
34%
-43
- C2 -
-
5OBJ
2
AURKA_HUMAN
A:
[8-266]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
52.59
37%
-77
- C2 -
-
3TKH
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
52.54
34%
-50
- C2 -
-
3NRM
1
AURKA_HUMAN
A:
[7-265]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
A
A
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
52.53
35%
-51
- C2 -
-
3D2I
1
AURKA_MOUSE
A:
[8-266]
--------------------------------------------------
Q
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
--------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-
L
T
L
A
E
V
L
E
H
----
P
W
I
----
K
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
52.46
42%
-21
- C2 -
-
4CZU
3
CIPKN_ARATH
D:
[10-277]
---------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
-
N
K
M
I
-
A
-
Q
I
----
K
R
E
I
S
T
M
-
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
G
L
---
L
H
D
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
--
C
--
P
P
----
W
------
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
---
G
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
52.42
32%
-39
- C2 -
-
2J4Z
2
AURKA_HUMAN
B:
[29-288]
----------------------------------------
R
---------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
52.36
37%
-63
- C2 -
-
2YDK
6
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
52.39
42%
-23
- C2 -
-
4CZU
3
CIPKN_ARATH
C:
[10-278]
---------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
-
N
K
M
I
-
A
-
Q
I
----
K
R
E
I
S
T
M
-
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
G
L
---
L
H
D
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
--
C
--
P
P
----
W
------
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
---
G
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
52.39
42%
-22
- C2 -
-
4CZT
3
CIPKN_ARATH
A:
[10-275]
---------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
-
N
K
M
I
-
A
-
Q
I
----
K
R
E
I
S
T
M
-
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
G
L
---
L
H
T
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
--
C
--
P
P
----
W
------
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
---
G
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
52.38
37%
-67
- C2 -
-
4QYF
1
CHK1_HUMAN
A:
[4-268]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
52.37
35%
-43
- C2 -
-
4DEB
3
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
52.36
37%
-69
- C2 -
-
1NVS
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
52.35
34%
-46
- C2 -
-
5DOS
2
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
52.33
37%
-65
- C2 -
-
2CGX
1
CHK1_HUMAN
A:
[6-266]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
52.24
34%
-51
- C2 -
-
2XRU
1
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
52.30
37%
-74
- C2 -
-
2YM6
6
CHK1_HUMAN
A:
[7-266]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
52.29
42%
-26
- C2 -
-
4CZU
3
CIPKN_ARATH
A:
[10-278]
---------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
-
N
K
M
I
-
A
-
Q
I
----
K
R
E
I
S
T
M
-
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
G
L
---
L
H
D
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
--
C
--
P
P
----
W
------
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
---
G
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
52.26
37%
-70
- C2 -
-
4FSN
2
CHK1_HUMAN
A:
[2-264]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
------------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
52.24
40%
-61
- C2 -
-
3HX4
3
?
A:
[52-310]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
-------------
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
52.21
37%
-69
- C2 -
-
2QHN
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
52.18
37%
-72
- C2 -
-
2BRH
1
CHK1_HUMAN
A:
[6-266]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
52.20
34%
-43
- C2 -
-
3R22
1
AURKA_HUMAN
A:
[7-265]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
52.14
34%
-43
- C2 -
-
5DN3
2
AURKA_HUMAN
A:
[8-266]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
-
S
R
R
---
T
-
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
52.18
37%
-70
- C2 -
-
2QHM
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
52.18
42%
-27
- C2 -
-
4CZT
3
CIPKN_ARATH
C:
[10-273]
---------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
-
N
K
M
I
-
A
-
Q
I
----
K
R
E
I
S
T
M
-
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
L
K
---
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
R
E
-
D
G
L
---
L
H
T
---
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
--
C
--
P
P
----
W
------
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
-
I
T
F
A
E
V
I
E
N
----
E
W
F
----
K
-----
K
---
G
Y
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
52.15
35%
-37
- C2 -
-
3UNZ
3
AURKA_HUMAN
B:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
52.14
37%
-66
- C2 -
-
2X8I
2
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
------------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
52.13
35%
-40
- C2 -
-
3UO6
3
AURKA_HUMAN
B:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
52.12
32%
-33
- C2 -
-
2J4Z
4
AURKA_HUMAN
A:
[29-288]
----------------------------------------
R
---------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
52.10
38%
-10
- C2 -
-
6C9J
2
AAPK1_HUMAN
A:
[13-494]
---------------------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------
F
Y
L
A
T
S
P
P
D
S
F
L
D
D
H
H
L
T
R
P
H
P
E
R
V
P
F
-----------
L
D
E
L
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
52.08
35%
-38
- C2 -
-
3UO4
4
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
52.08
35%
-39
- C2 -
-
3UOJ
1
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
52.07
35%
-42
- C2 -
-
4DEE
1
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
52.01
38%
-84
- C2 -
-
6T6F
1
?
A:
[16-287]
------------------------------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
-
A
T
G
K
L
F
A
V
K
C
I
P
K
K
---
A
-
L
--
K
-
G
K
E
--
S
-
S
I
----
E
N
E
I
A
V
L
-
R
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
-
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
---
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
E
---
E
---
S
K
---
I
M
I
S
D
F
G
L
S
-------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-
G
Y
P
P
F
Y
--
D
E
N
D
S
K
L
F
E
Q
I
L
K
A
-
E
Y
--
E
--
F
DS
P
Y
----
W
DD----
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
-
Y
T
C
E
Q
A
A
R
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
52.00
37%
-73
- C2 -
-
4FTJ
3
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
----------------
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
51.98
34%
-43
- C2 -
-
5DR2
2
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
A
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
51.94
34%
-44
- C2 -
-
4UZD
1
AURKA_HUMAN
B:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
------------
R
---
R
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
51.89
37%
-70
- C2 -
-
2X8E
1
CHK1_HUMAN
A:
[9-266]
------------------------------------------------------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
51.88
37%
-78
- C2 -
-
4FTL
2
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
51.88
37%
-73
- C2 -
-
4RVL
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
51.89
34%
-54
- C2 -
-
3MYG
2
AURKA_HUMAN
A:
[7-266]
-------------------------------------------------
R
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
51.88
35%
-38
- C2 -
-
3UOJ
1
AURKA_HUMAN
B:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
51.88
37%
-33
- C2 -
-
2UZU
1
KAPCA_BOVIN
E:
[20-276]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
---
T
W
T
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
51.86
35%
-40
- C2 -
-
3UOK
1
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
51.81
34%
-47
- C2 -
-
5DRD
1
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
51.83
34%
-45
- C2 -
-
4UZD
1
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
-------------
R
---
R
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
51.81
35%
-42
- C2 -
-
3UP7
1
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
51.77
37%
-75
- C2 -
-
4FT5
2
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
51.79
35%
-53
- C2 -
-
3DJ5
1
AURKA_MOUSE
A:
[9-266]
---------------------------------------------------
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
-----------------
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-
L
T
L
A
E
V
L
E
H
----
P
W
I
----
K
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
51.78
37%
-70
- C2 -
-
5DLS
1
CHK1_HUMAN
A:
[6-266]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
51.77
35%
-39
- C2 -
-
3UOK
1
AURKA_HUMAN
B:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
51.74
34%
-53
- C2 -
-
1OL6
1
AURKA_HUMAN
A:
[7-264]
---------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
-
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
---
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
N
F
G
W
S
---
V
H
-------------------
T
L
D
Y
L
P
P
E
M
I
E
G
-
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
51.71
37%
-74
- C2 -
-
2WMV
1
CHK1_HUMAN
A:
[7-266]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
51.65
34%
-51
- C2 -
-
4UYN
1
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
--
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
---------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
51.69
34%
-48
- C2 -
-
5DT0
1
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
51.67
34%
-48
- C2 -
-
3P9J
1
AURKA_HUMAN
A:
[3-262]
-------------------------------------------------
R
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
51.66
35%
-44
- C2 -
-
4DED
4
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
51.66
38%
2
- C2 -
-
4CFH
2
AAPK1_RAT
A:
[29-448]
-----------------------------------------------------RVK-
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DP----------------------------------------
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------
F
Y
L
A
T
S
P
P
D
S
F
L
D
D
H
H
L
T
R
P
H
-
P
E
R
V
P
F
L
V
A
E
T
P
R
A
R
H
L
D
E
L
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
51.65
35%
-40
- C2 -
-
3UOH
4
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
51.61
35%
-37
- C2 -
-
3UNZ
3
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
51.50
37%
-66
- C2 -
-
3U9N
1
CHK1_HUMAN
A:
[6-265]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
-------------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
51.58
34%
-44
- C2 -
-
5DT4
2
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
51.57
37%
-73
- C2 -
-
4FSM
3
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
51.55
34%
-43
- C2 -
-
4C3R
1
AURKA_HUMAN
A:
[6-264]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
51.53
34%
-49
- C2 -
-
3H0Z
1
AURKA_HUMAN
A:
[5-262]
---------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
51.50
34%
-46
- C2 -
-
3K5U
1
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
51.52
34%
-55
- C2 -
-
6CPG
1
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
-----------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
51.51
38%
-14
- C2 -
-
4RER
3
AAPK1_HUMAN
A:
[5-518]
---------------------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
S
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS----
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------
F
Y
L
A
T
S
P
P
D
----
D
H
H
L
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
A
R
H
T
L
D
E
L
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
51.50
34%
-47
- C2 -
-
6CPG
1
AURKA_HUMAN
D:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
51.49
34%
-47
- C2 -
-
3M11
1
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
51.48
34%
-49
- C2 -
-
5DR6
2
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
--------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
51.47
35%
-50
- C2 -
-
3DJ6
1
AURKA_MOUSE
A:
[9-266]
---------------------------------------------------
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
-----------------
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-
L
T
L
A
E
V
L
E
H
----
P
W
I
----
K
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
51.44
34%
-43
- C2 -
-
4JAJ
1
AURKA_HUMAN
A:
[15-273]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
51.44
34%
-49
- C2 -
-
1MUO
1
AURKA_HUMAN
A:
[22-279]
---------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
51.36
38%
-2
- C2 -
-
5KQ5
2
?
A:
[12-503]
-----------------------------------------------------RVK-
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
---------------
L
A
T
S
P
P
D
S
F
L
--
H
H
L
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
----
T
L
D
E
L
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
51.32
34%
-52
- C2 -
-
4JAI
1
AURKA_HUMAN
A:
[15-273]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
---------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
51.32
34%
-45
- C2 -
-
5OBR
2
AURKA_HUMAN
A:
[8-266]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
51.33
37%
-71
- C2 -
-
2YM4
4
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
-------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
51.32
40%
-34
- C2 -
-
4ONA
1
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
51.30
37%
-74
- C2 -
-
4FTR
3
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
--
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
--------------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
51.22
37%
-72
- C2 -
-
3PA4
4
CHK1_HUMAN
A:
[5-265]
---------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
51.15
35%
-40
- C2 -
-
3UOH
3
AURKA_HUMAN
B:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
D
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
51.09
37%
-73
- C2 -
-
4FSQ
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
----------------
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
51.05
34%
-41
- C2 -
-
3E5A
1
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
-
S
R
R
---
T
-
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
51.09
34%
-49
- C2 -
-
6GRA
1
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
-------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
51.08
34%
-42
- C2 -
-
1MQ4
1
AURKA_HUMAN
A:
[7-266]
-------------------------------------------------
R
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
-----
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
51.07
34%
-49
- C2 -
-
5DPV
2
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
51.05
37%
-72
- C2 -
-
2YM3
6
CHK1_HUMAN
A:
[8-266]
-----------------------------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
51.05
34%
-49
- C2 -
-
2C6E
1
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
-----------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
51.01
34%
-50
- C2 -
-
3R21
1
AURKA_HUMAN
A:
[7-265]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
-----------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
50.95
37%
-76
- C2 -
-
4FTK
2
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
50.96
35%
16
- C2 -
-
5N23
1
KAPCA_HUMAN
A:
[9-298]
---------------------
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
Q
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
--
V
-
K
G
R
---
T
P
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
50.93
34%
-44
- C2 -
-
2C6D
2
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
50.95
37%
-71
- C2 -
-
4FTT
4
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
50.94
34%
-59
- C2 -
-
4C3P
1
AURKA_HUMAN
D:
[6-264]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
50.93
34%
-41
- C2 -
-
2X6D
1
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
------
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
50.90
34%
-46
- C2 -
-
5ONE
1
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
----------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
50.89
37%
-74
- C2 -
-
2WMT
1
CHK1_HUMAN
A:
[8-266]
-----------------------------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
50.86
34%
-49
- C2 -
-
6C2R
1
AURKA_HUMAN
A:
[9-266]
---------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
--------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
50.84
37%
-68
- C2 -
-
2WMR
1
CHK1_HUMAN
A:
[7-266]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
50.84
38%
-14
- C2 -
-
6C9G
2
AAPK1_HUMAN
A:
[13-493]
---------------------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------
F
Y
L
A
T
S
P
P
D
S
F
L
D
D
H
H
L
T
R
P
H
P
E
R
V
P
F
L
-----------
D
E
L
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
50.77
34%
-47
* C2 *
-
4ZS0
1
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
--------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
50.76
37%
-75
- C2 -
-
4FTO
4
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
--------------
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
50.69
34%
-49
- C2 -
-
3LAU
1
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
----------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
50.63
40%
-33
- C2 -
-
3T3U
5
?
A:
[28-297]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
50.62
37%
-75
- C2 -
-
2XF0
5
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
50.59
37%
-75
- C2 -
-
4FTM
5
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
50.56
37%
-78
- C2 -
-
2WMU
1
CHK1_HUMAN
A:
[9-266]
------------------------------------------------------------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
50.56
34%
-43
- C2 -
-
4ZTR
1
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
50.56
39%
-30
- C2 -
-
3MA6
1
?
B:
[34-295]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-----
T
---
Y
T
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
50.55
34%
-52
- C2 -
-
2X81
1
AURKA_HUMAN
A:
[8-266]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
---
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
----------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
50.51
37%
-73
- C2 -
-
2WMX
1
CHK1_HUMAN
A:
[7-266]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
50.47
40%
-31
- C2 -
-
4YJN
1
?
A:
[28-291]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
50.42
34%
-41
- C2 -
-
4JBP
1
AURKA_HUMAN
A:
[5-263]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
50.32
34%
-52
- C2 -
-
3VAP
1
AURKA_HUMAN
A:
[8-266]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
50.29
43%
-31
- C2 -
-
3HZT
9
?
A:
[6-295]
------------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
-
L
T
G
A
E
R
A
I
K
I
I
K
K
S
---
S
-
V
--
T
-
T
T
S
N
-
S
G
A
L
----
L
D
E
V
A
V
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
--
K
F
S
---
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSR
D
---
A
L
---
I
K
I
V
D
F
G
L
S
---
A
H
F
E
V
---------------
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
------
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
-
G
Y
P
P
F
G
--
G
Q
T
D
Q
E
I
L
K
R
V
E
K
G
-
K
F
--
S
--
F
DP
P
D
----
W
TQ----
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
-
I
S
A
E
E
A
L
N
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
50.26
34%
-46
- C2 -
-
4O0S
1
AURKA_HUMAN
A:
[6-264]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
---
R
-
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
50.24
39%
-78
- C2 -
-
4FG8
1
KCC1A_HUMAN
A:
[20-276]
------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
-
R
T
Q
K
L
V
A
I
K
C
I
A
K
------------------------
E
N
E
I
A
V
L
-
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
-
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
---
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
---
S
K
---
I
M
I
S
D
F
---------------------------
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
-
E
Y
--
E
--
F
DS
P
Y
----
W
DD----
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
-
F
T
C
E
Q
A
L
Q
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
50.21
34%
-48
- C2 -
-
3H0Y
1
AURKA_HUMAN
A:
[3-262]
-------------------------------------------------
R
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
50.19
39%
-73
- C2 -
-
4FG9
1
KCC1A_HUMAN
B:
[20-276]
------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
-
R
T
Q
K
L
V
A
I
K
C
I
A
K
--------------------------
E
I
A
V
L
-
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
-
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
---
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
---
S
K
---
I
M
I
S
D
F
--------------
V
---
L
S
T
---
A
C
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
-
E
Y
--
E
--
F
DS
P
Y
----
W
DD----
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
-
F
T
C
E
Q
A
L
Q
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
50.18
35%
-58
- C2 -
-
3D2K
1
AURKA_MOUSE
A:
[9-266]
---------------------------------------------------
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-------------------
T
L
D
Y
L
P
P
E
M
I
-----
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-
L
T
L
A
E
V
L
E
H
----
P
W
I
----
K
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
50.15
41%
-58
- C2 -
-
3LIJ
1
?
A:
[39-301]
------------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
-
V
T
H
V
E
R
A
I
K
I
I
R
K
------------
S
S
N
-
S
-
K
L
----
L
E
E
V
A
V
L
-
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
-
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
--
K
F
N
---
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KEK
D
---
A
L
---
I
K
I
V
D
F
G
L
S
---
A
V
F
E
N
-
Q
K
K
---
M
K
E
---
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
------
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
-
G
Y
P
P
F
G
--
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
-
K
Y
--
T
--
F
DS
P
E
----
W
KN----
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
-
I
S
A
Q
Q
A
L
E
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
50.13
40%
-31
- C2 -
-
3SXF
3
?
A:
[28-297]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
50.11
37%
-73
- C2 -
-
2WMW
1
CHK1_HUMAN
A:
[7-266]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
50.09
34%
-48
- C2 -
-
4ZTQ
2
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
50.07
40%
-33
- C2 -
-
3V5P
1
?
A:
[28-301]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
50.07
39%
-21
- C2 -
-
3MA6
1
?
A:
[34-296]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
--
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
-----
T
---
Y
T
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
50.06
37%
-74
- C2 -
-
2YM5
2
CHK1_HUMAN
A:
[8-266]
-----------------------------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
50.00
34%
-36
- C2 -
-
3H10
1
AURKA_HUMAN
D:
[3-262]
-------------------------------------------------
R
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
--------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
50.00
36%
-56
- C2 -
-
3DAJ
1
AURKA_MOUSE
A:
[8-266]
--------------------------------------------------
Q
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
------------------------
T
L
D
Y
L
P
P
E
M
I
----
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-
L
T
L
A
E
V
L
E
H
----
P
W
I
----
K
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
49.95
40%
-33
- C2 -
-
6BFA
1
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
49.94
34%
-147
- C2 -
-
3W2C
1
AURKA_HUMAN
A:
[3-258]
---------------------------------------------------------
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
---------------------
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
---------
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
----------------------------
T
L
D
Y
L
P
P
E
M
I
E
-------------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
--
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
------------
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
49.93
37%
-76
- C2 -
-
3OT8
4
CHK1_HUMAN
A:
[4-265]
----------------------------------------------------
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
49.86
39%
-80
- C2 -
-
4FG9
1
KCC1A_HUMAN
A:
[20-276]
------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
-
R
T
Q
K
L
V
A
I
K
C
I
A
K
E
-----------------------
E
N
E
I
A
V
L
-
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
-
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
Y
T
---
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
---
S
K
---
I
M
I
S
D
F
----------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
-
E
Y
--
E
--
F
DS
P
Y
----
W
DD----
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
-
F
T
C
E
Q
A
L
Q
H
----
P
W
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
49.90
34%
-48
- C2 -
-
4UZH
1
AURKA_HUMAN
A:
[4-262]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
----------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
49.86
40%
-32
- C2 -
-
4M84
1
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
49.85
35%
-33
- C2 -
-
3L9M
1
KAPCA_HUMAN
B:
[14-291]
-------------------------
E
S
-
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
49.77
37%
-74
- C2 -
-
2YM8
10
CHK1_HUMAN
A:
[8-266]
-----------------------------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
49.75
34%
-54
- C2 -
-
2J50
1
AURKA_HUMAN
B:
[5-262]
---------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
-------------
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
----
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
49.74
34%
-48
- C2 -
-
3W16
1
AURKA_HUMAN
A:
[2-260]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
-------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
49.73
40%
-31
- C2 -
-
3I7B
4
?
A:
[28-289]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
49.72
40%
-28
- C2 -
-
5T6K
1
?
A:
[69-358]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
--
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
49.71
37%
-71
- C2 -
-
2XEZ
7
CHK1_HUMAN
A:
[7-266]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
49.68
40%
-32
- C2 -
-
5W91
1
?
A:
[28-300]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
49.67
40%
-30
- C2 -
-
4MXA
1
?
A:
[29-293]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
49.66
40%
-33
- C2 -
-
4WG5
1
?
A:
[28-286]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
49.59
38%
-73
- C2 -
-
4MVF
2
CDPK2_PLAFK
A:
[47-481]
-------------------------------------------
L
I
L
C
H
S
G
K
L
E
-----
D
K
Y
I
I
D
E
K
L
G
Q
G
T
Y
G
C
V
Y
K
G
I
D
K
-
V
T
N
Q
L
Y
A
I
K
E
E
K
K
D
---
R
-
L
--
K
---
N
I
-
N
-
R
F
----
F
Q
E
I
E
I
M
-
K
K
L
D
H
P
N
I
V
K
L
Y
E
T
Y
-
E
N
D
N
Y
I
Y
L
I
M
E
L
C
S
G
R
E
L
F
D
S
I
I
E
N
G
--
S
F
T
---
E
K
N
A
A
T
I
M
K
Q
I
F
S
A
I
F
Y
L
H
S
L
N
I
V
H
R
D
L
K
P
E
N
F
L
---
F
---
Q
S
ENK
D
---
S
L
---
L
K
I
I
D
F
G
L
S
---
K
N
L
-------------------------------
K
Y
D
------
K
K
C
D
I
W
S
S
G
V
I
M
Y
T
L
L
C
-
G
Y
P
P
F
Y
---------------------------
C
F
----
Y
ENDWGS
I
S
S
D
A
K
N
L
I
T
K
L
L
T
Y
N
P
N
E
R
-
C
T
I
E
E
A
L
N
H
----
P
W
I
----
T
-----
Q
MTK
S
H
E
H
V
E
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
49.57
37%
-66
- C2 -
-
2WMQ
1
CHK1_HUMAN
A:
[7-266]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
--------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
---------
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
49.57
40%
-31
- C2 -
-
3KU2
1
?
A:
[51-316]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
49.56
34%
-54
- C2 -
-
2J50
1
AURKA_HUMAN
A:
[5-262]
---------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
-------------
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
----
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
49.54
34%
-49
- C2 -
-
6C83
1
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
--------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
49.54
40%
-29
- C2 -
-
5T6A
1
?
A:
[69-358]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
--
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
49.43
40%
-34
- C2 -
-
3T3V
2
?
A:
[28-296]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
49.40
40%
-33
- C2 -
-
3UPX
1
?
A:
[28-305]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
49.36
40%
-30
- C2 -
-
5W80
1
?
A:
[28-297]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
49.28
40%
-29
- C2 -
-
5W9R
1
?
A:
[28-305]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
49.26
34%
-66
- C2 -
-
3O51
1
AURKA_HUMAN
A:
[3-261]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
----------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
49.25
40%
-29
- C2 -
-
5JMS
2
?
A:
[69-344]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
49.23
40%
-31
- C2 -
-
4IH8
1
?
A:
[51-337]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
-SK-
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
49.18
40%
-31
- C2 -
-
4MX9
1
?
A:
[29-293]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
49.13
34%
-46
- C2 -
-
4ZTS
2
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
49.09
34%
-52
- C2 -
-
3O50
1
AURKA_HUMAN
A:
[3-261]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
-------------------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
49.05
34%
-152
- C2 -
-
3W2C
1
AURKA_HUMAN
C:
[3-258]
---------------------------------------------------------
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
---------------------
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
----------
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
----------------------------
T
L
D
Y
L
P
P
E
M
I
E
-------------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
--
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
------------
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
49.09
35%
-33
- C2 -
-
3L9N
1
KAPCA_HUMAN
A:
[15-294]
--------------------------
S
-
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
49.08
40%
-30
- C2 -
-
3N51
3
?
A:
[28-301]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
49.05
40%
-33
- C2 -
-
4WG4
1
?
A:
[28-297]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
49.04
38%
15
- C2 -
-
6E4W
2
?
A:
[11-503]
-----------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------
F
Y
L
A
T
S
P
P
D
S
-----------P
E
R
V
P
-------
R
A
R
H
T
----
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
49.01
40%
-26
- C2 -
-
5JN2
1
?
A:
[69-342]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
48.99
32%
-54
- C2 -
-
3EFW
1
AURKA_HUMAN
A:
[126-385]
----------------------------------------
R
---------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
----------------------------
L
D
Y
L
P
P
E
M
I
-----------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
48.84
37%
-75
- C2 -
-
3PA5
4
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
48.88
35%
-33
- C2 -
-
3L9M
1
KAPCA_HUMAN
A:
[12-291]
-----------------------
E
Q
E
S
-
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
48.84
34%
-44
- C2 -
-
6C83
1
AURKA_HUMAN
B:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
--------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
48.81
38%
-6
- C2 -
-
6C9F
2
AAPK1_HUMAN
A:
[13-493]
---------------------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
L
Y
Q
---
F
Y
L
A
T
S
P
P
D
S
F
L
-----------
R
V
P
F
L
V
A
E
T
P
R
A
R
H
T
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
48.74
34%
-44
- C2 -
-
3H0Z
1
AURKA_HUMAN
B:
[3-262]
-------------------------------------------------
R
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
------
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
----------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
48.62
37%
-7
- C2 -
-
2E9U
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
48.67
38%
10
- C2 -
-
5UFU
2
AAPK1_MOUSE (first)
A:
[11-503]
-----------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
Q
-----
F
Y
L
A
T
S
P
P
D
S
F
L
-----------
R
V
P
F
---
E
T
P
R
A
R
H
T
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
48.62
37%
-76
- C2 -
-
2YM7
5
CHK1_HUMAN
A:
[7-266]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
---------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
48.57
34%
-47
- C2 -
-
4B0G
1
AURKA_HUMAN
A:
[7-265]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
-------
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
--------------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
48.53
34%
-45
- C2 -
-
4BYJ
1
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
----------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
48.38
34%
-42
- C2 -
-
2C6E
1
AURKA_HUMAN
B:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
---------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
48.37
38%
13
- C2 -
-
4QFS
2
AAPK1_RAT
A:
[11-503]
-----------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------
F
Y
L
A
T
S
P
P
D
S
-----------P
E
R
V
P
-------
R
A
R
H
T
----
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
48.34
32%
-53
- C2 -
-
3EFW
1
AURKA_HUMAN
B:
[126-385]
----------------------------------------
R
---------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
----------------------------
L
D
Y
L
P
P
E
M
I
E
----------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
48.29
40%
-27
- C2 -
-
4IFG
1
?
A:
[51-321]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
48.25
40%
-30
- C2 -
-
5W9E
1
?
A:
[28-299]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
48.19
37%
-5
- C2 -
-
2E9O
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
48.14
34%
-143
- C2 -
-
3W2C
1
AURKA_HUMAN
G:
[3-258]
---------------------------------------------------------
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
---------------------
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
----------
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
----------------------------
T
L
D
Y
L
P
P
E
M
I
E
-------------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
--
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
------------
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
48.05
37%
-10
- C2 -
-
2AYP
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
48.02
38%
11
- C2 -
-
6E4U
2
AAPK1_RAT
A:
[11-503]
-----------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
---------------
A
T
S
P
P
D
S
F
L
-
D
H
H
L
T
R
P
H
P
E
R
V
P
F
L
V
A
E
T
P
R
----
L
D
E
L
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
47.93
38%
15
- C2 -
-
4QFR
2
?
A:
[11-503]
-----------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------
F
Y
L
A
T
S
P
P
D
S
-----------P
E
R
V
P
-------
R
A
R
H
T
----
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
47.90
34%
-150
- C2 -
-
3W2C
1
AURKA_HUMAN
E:
[3-258]
---------------------------------------------------------
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
---------------------
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
----------
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
----------------------------
T
L
D
Y
L
P
P
E
M
I
E
-------------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
--
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
------------
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
47.78
37%
-71
- C2 -
-
2WMS
1
CHK1_HUMAN
A:
[7-266]
----------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
----------------
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
47.77
34%
-15
- C2 -
-
5VIB
1
KAPCA_BOVIN
A:
[35-351]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
---
I
Y
Q
R
K
V
E
A
P
F
I
P
K
---------------
F
D
-----
D
Y
E
E
E
E
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
47.74
37%
-7
- C2 -
-
6FCK
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
47.73
38%
21
- C2 -
-
4QFG
1
AAPK1_RAT
A:
[11-503]
-----------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------
F
Y
L
A
T
S
P
P
D
S
-----------P
E
R
V
---
V
A
E
T
P
R
A
R
H
T
----
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
47.60
34%
-27
- C2 -
-
4BN1
1
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
M
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
-
S
R
R
---
L
T
-----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
47.53
37%
-32
- C2 -
-
1XH5
3
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
47.50
37%
-28
- C2 -
-
6E9L
1
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
47.35
37%
-34
- C2 -
-
6E99
1
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
47.37
37%
-8
- C2 -
-
2YDI
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
47.35
34%
-51
- C2 -
-
3O50
1
AURKA_HUMAN
B:
[3-261]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
-------------------
T
T
---
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
----
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
47.32
38%
14
- C2 -
-
6E4T
2
?
A:
[11-503]
-----------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
------
F
Y
L
A
T
S
P
P
D
S
-----------P
E
R
V
P
-------
R
A
R
H
T
----
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
47.31
37%
-3
- C2 -
-
2YEX
8
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
47.29
38%
-51
- C2 -
-
4JXF
2
PLK4_HUMAN
A:
[1-257]
----------------------------------------------
C
I
G
E
K
------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
-
H
T
G
L
E
V
A
I
K
M
I
D
K
K
---
A
-
M
--
Y
-
K
A
G
M
V
Q
-
R
V
----
Q
N
E
V
K
I
H
-
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
-
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
--
R
V
K
PFS
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
---
N
---
M
N
---
I
K
I
A
D
F
G
L
A
---
T
Q
L
K
M
P
H
-------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
-
G
R
P
P
F
------
V
K
N
T
L
N
K
V
V
L
A
-
D
Y
--
E
--
M
--
P
S
----
F
------
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
-
L
S
L
S
S
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
47.22
37%
-32
- C2 -
-
2GNF
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
47.20
38%
-29
- C2 -
-
2GNL
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
47.17
37%
-29
- C2 -
-
1XH8
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
47.11
37%
-4
- C2 -
-
2E9N
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
47.06
40%
-37
- C2 -
-
5T6I
1
?
A:
[69-361]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
------
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK----
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
M
K
D
---
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
--
L
--
P
Q
----
W
KK----
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-
I
S
A
R
D
A
L
D
H
----
E
W
I
----
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
47.02
37%
-7
- C2 -
-
2GHG
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
46.99
37%
-4
- C2 -
-
2E9V
1
CHK1_HUMAN
B:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
46.93
37%
-8
- C2 -
-
2X8D
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
46.92
37%
-3
- C2 -
-
2YWP
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
46.87
39%
27
- C2 -
-
1PHK
1
PHKG1_RABIT
A:
[18-282]
-----------------------------------------------------------
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
-
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
GGG
S
-
F
--
S
-
A
E
E
V
-
Q
-
E
L
REAT
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
-
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
--
T
L
S
---
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
D
---
M
N
---
I
K
L
T
D
F
G
F
S
---
C
Q
L
D
P
-
G
E
K
---
L
R
E
---
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
NHPGY
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
-
G
S
P
P
F
W
--
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
-
N
Y
--
Q
--
F
GS
P
E
----
W
DD----
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
-
Y
T
A
E
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
46.80
37%
-29
- C2 -
-
1XH6
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
46.85
37%
-26
- C2 -
-
2JDT
1
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
46.80
37%
-2
- C2 -
-
6FC8
1
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
46.72
37%
-5
- C2 -
-
2E9P
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
46.67
35%
10
- C2 -
-
3AMB
1
KAPCA_HUMAN
A:
[4-296]
----------------
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
Q
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
46.66
37%
-28
- C2 -
-
1Q24
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
46.65
37%
-29
- C2 -
-
1Q8T
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
46.57
37%
-27
- C2 -
-
2UVX
1
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
46.57
38%
-22
- C2 -
-
4QOX
1
CDPK4_PLAF7
A:
[79-447]
------------------------------------------------------------
Y
K
G
I
K
I
L
G
K
G
S
F
G
E
V
I
L
S
R
D
K
-
H
T
G
H
E
Y
A
I
K
V
I
S
K
K
---
H
-
V
--
K
R
K
T
D
K
-
E
-
S
L
----
L
R
E
V
E
L
L
-
K
M
L
D
H
I
N
I
M
K
L
Y
E
F
F
-
E
D
N
N
Y
Y
Y
L
V
S
D
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
Y
---
E
I
D
A
A
R
I
I
K
Q
I
L
S
G
I
T
Y
M
H
K
N
N
V
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
T
KNE
D
---
M
I
---
I
K
I
I
D
F
G
L
S
---
T
H
F
E
Y
-
S
-----------
K
I
G
T
A
Y
Y
I
A
P
D
V
L
H
G
-
T
Y
D
------
E
K
C
D
I
W
S
C
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
S
N
E
Y
D
I
L
K
K
V
E
A
G
-
K
Y
--
T
FD
L
--
P
Q
----
F
KK----
I
S
D
K
A
K
D
L
I
K
K
M
L
M
Y
T
S
A
V
R
-
I
S
A
R
D
A
L
E
H
----
E
W
I
----
K
-----
M
---
M
T
S
K
D
N
L
N
I
D
I
-
P
S
------
L
E
L
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
46.55
38%
-62
- C2 -
-
3COK
1
PLK4_HUMAN
B:
[1-261]
------------------------------------------
S
L
A
T
C
I
G
E
K
------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
-
H
T
G
L
E
V
A
I
K
M
I
D
K
K
---
A
-
M
--
Y
-
K
A
G
M
V
Q
-
R
V
----
Q
N
E
V
K
I
H
-
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
-
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
--
R
V
K
PFS
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
---
N
---
M
N
---
I
K
I
A
D
F
G
L
A
---
T
Q
L
K
---------------------------------------
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
-
G
R
P
P
F
--------
N
T
L
N
K
V
V
L
A
-
D
Y
--
E
--
M
--
P
S
----
F
------
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
-
L
S
L
S
S
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
46.48
37%
-32
- C2 -
-
1STC
1
KAPCA_BOVIN
E:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
46.37
37%
-29
- C2 -
-
2VO7
2
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
46.36
37%
-31
- C2 -
-
1VEB
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
46.40
37%
-29
- C2 -
-
1Q8U
3
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
46.37
37%
-30
- C2 -
-
2GNH
2
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
46.36
37%
-26
- C2 -
-
2UW7
1
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
46.19
37%
-28
- C2 -
-
3ZO4
4
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
46.24
37%
-29
- C2 -
-
4YXS
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
46.19
37%
-24
- C2 -
-
2UW4
1
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
-
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
46.09
37%
-25
- C2 -
-
4IJ9
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
46.03
37%
-4
- C2 -
-
2E9V
1
CHK1_HUMAN
A:
[3-265]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
46.03
37%
-26
- C2 -
-
4AXA
1
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
46.06
37%
-25
- C2 -
-
2VO0
4
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
46.05
38%
-25
- C2 -
-
2GNJ
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
46.03
37%
-25
- C2 -
-
4Z84
1
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
46.03
39%
28
- C2 -
-
2PHK
2
PHKG1_RABIT
A:
[5-269]
-----------------------------------------------------------
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
-
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
GGG
S
-
F
--
S
-
A
E
E
V
-
Q
-
E
L
REAT
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
-
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
--
T
L
S
---
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
D
---
M
N
---
I
K
L
T
D
F
G
F
S
---
C
Q
L
D
P
-
G
E
K
---
L
R
E
---
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
NHPGY
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
-
G
S
P
P
F
W
--
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
-
N
Y
--
Q
--
F
GS
P
E
----
W
DD----
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
-
Y
T
A
E
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
46.02
37%
-31
- C2 -
-
4IE9
2
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
45.95
37%
-28
- C2 -
-
2C1B
1
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
46.01
37%
-28
- C2 -
-
4YXR
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
46.00
37%
-32
- C2 -
-
2C1A
1
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
45.98
38%
14
- C2 -
-
5T5T
2
AAPK1_RAT
A:
[11-503]
-----------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
-
S
L
D
V
-
V
G
K
I
----
R
R
E
I
Q
N
L
-
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
L
D
---
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
S
D
-
G
E
F
---
L
R
S
----
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
--
T
--
P
Q
----
Y
------
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-
A
T
I
K
D
I
R
E
H
----
E
W
F
-----------------
K
Q
D
L
P
K
Y
L
F
P
E
DPSYSS
T
M
I
D
D
E
A
L
K
E
V
C
E
K
F
E
C
S
E
E
E
V
L
S
C
L
Y
N
R
N
H
Q
D
PL
A
V
A
Y
H
L
I
I
D
N
R
R
I
M
N
E
A
K
D
Q
-----
F
Y
L
A
T
S
P
P
D
S
F
L
-----------
R
V
P
F
---
E
T
P
R
A
R
H
T
L
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
45.95
37%
-30
- C2 -
-
2JDV
1
KAPCA_BOVIN
A:
[35-291]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
45.90
37%
-28
- C2 -
-
1SVH
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
45.86
37%
-27
- C2 -
-
2GNI
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
45.83
37%
-3
- C2 -
-
2YER
7
CHK1_HUMAN
A:
[4-266]
---------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
-
P
E
N
I
-
K
-
K
-------
E
I
C
I
N
-
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
M
P
---
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
R
Y
-
N
N
R
ERL
L
N
K
---
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
--
N
--
P
W
K---
K
------
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
-
I
T
I
P
D
I
K
K
D
----
R
W
Y
----
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
45.60
34%
-36
- C2 -
-
1OL7
1
AURKA_HUMAN
A:
[6-264]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
-
S
R
R
---
L
T
-----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
45.57
35%
-36
- C2 -
-
6GR9
1
AURKC_HUMAN
A:
[9-264]
---------------------------------------------------------
V
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
L
K
-
E
S
H
F
I
V
A
L
K
V
L
F
K
S
---
Q
-
I
--
E
-
K
E
G
L
-
E
H
Q
L
----
R
R
E
I
E
I
Q
-
A
H
L
Q
H
P
N
I
L
R
L
Y
N
Y
F
-
H
D
A
R
R
V
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
D
--
K
L
D
---
E
Q
R
T
A
T
I
I
E
E
L
A
D
A
L
T
Y
C
H
D
K
K
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
F
---
R
---
G
E
---
V
K
I
A
D
F
G
W
S
---
V
H
T
P
S
-
L
R
R
-----
K
---
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
T
Y
D
------
E
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
-
G
Y
P
P
F
E
--
S
A
S
H
S
E
T
Y
R
R
I
L
K
V
-
D
V
--
R
--
F
--
P
L
----
S
------
M
P
L
G
A
R
D
L
I
S
R
L
L
R
Y
Q
P
L
E
R
-
L
P
L
A
Q
I
L
K
H
----
P
W
V
----
Q
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
45.55
37%
-25
- C2 -
-
1YDR
1
KAPCA_BOVIN
E:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
45.38
37%
-23
- C2 -
-
3DNE
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
45.29
34%
-22
- C2 -
-
6I2U
4
AURKA_HUMAN
A:
[9-267]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
-
S
R
R
---
L
T
-----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
45.25
38%
-58
- C2 -
-
4YUR
1
PLK4_HUMAN
A:
[8-263]
-----------------------------------------------
I
G
E
K
------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
-
H
T
G
L
E
V
A
I
K
M
I
D
K
K
---
A
-
M
--
Y
-
K
A
G
M
V
Q
-
R
V
----
Q
N
E
V
K
I
H
-
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
-
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
--
R
V
K
PFS
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
---
N
---
M
N
---
I
K
I
A
D
F
------------------------------------------------
G
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
-
G
R
P
P
F
-----
T
V
K
N
T
L
N
K
V
V
L
A
-
D
Y
--
E
--
M
--
P
S
----
F
------
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
-
L
S
L
S
S
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
45.03
37%
-27
- C2 -
-
3DND
1
KAPCA_BOVIN
A:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
44.90
38%
-57
- C2 -
-
3COK
1
PLK4_HUMAN
A:
[1-261]
------------------------------------------
S
L
A
T
C
I
G
E
K
------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
-
H
T
G
L
E
V
A
I
K
M
I
D
K
K
---
A
-
M
--
Y
-
K
A
G
M
V
Q
-
R
V
----
Q
N
E
V
K
I
H
-
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
-
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
--
K
N
--
R
V
K
PFS
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
---
N
---
M
N
---
I
K
I
A
D
F
G
L
A
---
T
Q
L
K
----------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
-
G
R
P
P
F
D
--
T
D
T
V
-----
K
V
V
L
A
-
D
Y
--
E
--
M
--
P
S
----
F
------
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
-
L
S
L
S
S
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
44.76
34%
-32
- C2 -
-
1OL5
1
AURKA_HUMAN
A:
[6-264]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
A
P
S
-
S
R
R
---
L
T
-----
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
--
F
--
P
D
----
F
------
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-
P
M
L
R
E
V
L
E
H
----
P
W
I
----
T
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
44.75
37%
-24
- C2 -
-
4Z83
2
KAPCA_BOVIN
E:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
44.71
37%
-29
- C2 -
-
1YDS
1
KAPCA_BOVIN
E:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
44.46
37%
-28
- C2 -
-
1YDT
1
KAPCA_BOVIN
E:
[34-290]
-----------------------------------------------
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
D
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
44.13
34%
-9
- C2 -
-
5VI9
1
KAPCA_BOVIN
A:
[35-351]
-----------------------------------------------
A
Q
N
T
A
H
----
L
------
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
L
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
IKNH
K
W
F
----
A
TTDWI
A
---
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
------
K
G
P
----
N
F
D
-----
D
Y
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
43.85
35%
-31
- C2 -
-
6GR8
1
AURKC_HUMAN
A:
[9-264]
---------------------------------------------------------
V
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
L
K
-
E
S
H
F
I
V
A
L
K
V
L
F
K
S
---
Q
-
I
--
E
-
K
E
G
L
-
E
H
Q
L
----
R
R
E
I
E
I
Q
-
A
H
L
Q
H
P
N
I
L
R
L
Y
N
Y
F
-
H
D
A
R
R
V
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
D
--
K
L
D
---
E
Q
R
T
A
T
I
I
E
E
L
A
D
A
L
T
Y
C
H
D
K
K
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
F
---
R
---
G
E
---
V
K
I
A
D
F
G
W
S
---
V
H
T
P
S
-
L
R
R
-----
K
---
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
T
Y
D
------
E
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
-
G
Y
P
P
F
E
--
S
A
S
H
S
E
T
Y
R
R
I
L
K
V
-
D
V
--
R
--
F
--
P
L
----
S
------
M
P
L
G
A
R
D
L
I
S
R
L
L
R
Y
Q
P
L
E
R
-
L
P
L
A
Q
I
L
K
H
----
P
W
V
----
Q
-----
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
555
Fugue
41.45
32%
-21
- C2 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
------------------------------------------------
G
W
A
L
N
----
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G---
N
K
V
A
V
K
C
I
-
K
------------
N
D
A
-
Q
-
A
F
----
L
A
E
A
S
V
M
-
T
Q
L
R
H
S
N
L
V
Q
L
L
G
V
I
V--
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
RS
V
L
G
---
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
---
V
---
S
E
---
D
---
N
V
---
A
K
V
S
D
F
G
------------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
------
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
--
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
--
D
--
A
--
P
D
----
G
------
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
-
P
S
F
L
Q
L
R
E
Q
----
L
E
H
----
I
-----
K
---
T
H
E
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
41.00
44%
-37
- C2 -
-
3NYV
1
?
A:
[28-253]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
K
D
K
---
I
-
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
-
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
40.90
44%
-36
- C2 -
-
3I7C
1
?
A:
[28-247]
------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
-
K
T
D
K
-
E
-
S
L
----
L
R
E
V
Q
L
L
-
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
F
S
---
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
E
A
-
S
K
K
---
K
D
K
---
I
-
G
T
A
Y
Y
I
A
P
E
V
L
H
G
T
-
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
36.32
35%
7
- C2 -
-
3AMA
1
KAPCA_HUMAN
A:
[3-296]
----------------
N
A
A
A
A
K
K
G
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
S
P
A
Q
N
T
A
H
----
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
-
L
K
Q
I
-
E
-
H
T
----
L
N
E
K
R
I
Q
-
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
--
V
-
K
G
R
----
T
W
---
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
------
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
--
F
--
P
S
----
H
------
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G
N
L
K
N
G
V
N
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
34.59
34%
-79
- C2 -
-
2NP8
1
AURKA_HUMAN
A:
[8-166]
--------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
-
K
A
G
V
-
E
H
Q
L
----
R
R
E
V
E
I
Q
-
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
F
D
---
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-
A
P
-
S
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
-------------------------------------------------------------------------------------------------------