@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MARK4_HUMAN: (2020-09-15 )
MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
Atome Classification :
(418 SA)
.........10........20........30....-....40.....----.----..50.----...----....60........70........-80........90..---.-.--.--.-..100-.-..----......110..-.....120...-....130.......140.......150-.-.......160.......170..-.....180......---.---190--.---..---.....200.---...-..-.-210--........220.......230.-----......240.......250......--..260.......270..--..--..----.--.280.......290.......-----300.....----------..310..----.....320.......330...------....340.......350.......360.......370.........380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSS
R
T
V
LAPGNDRNSDTHGTLGSGRSSDKGPSWSS-R
S
L
G
A
R
C
R
N
S
I
----A----SCPEE----QPH----VG
N
Y
R
L
L
R
T
IGKGNF
A
K
V
K
L
A
R
H
I
-LTG
R
E
V
A
I
K
I
I
DKT---Q-L--
N
--
P
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
KGLN-H
P
N
I
V
K
L
F
E
V
I
-ETE
K
T
L
Y
L
V
M
EYASA
G
E
V
F
D
Y
L
V
SHG--R-M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q-KN
I
V
H
R
DLKAE
N
L
L
---L---DA---E---A
N
---
I
K
I
A
DFGFS---NEF-TL-G-SK---
L
D
T
FCGSPPYAA
P
E
LFQGKKYD-----GPE
V
D
I
W
S
L
G
V
I
L
Y
T
L
VS-GSLPFD--GH
N
L
K
E
L
R
E
R
V
LRG-KY--RV--
P
F
----
Y
--MST
D
C
E
S
I
L
R
R
F
L
VLN
P
A
K
R
C
-----
T
L
E
Q
I
M
K
D----------K
W
I
NIGY----EGEELKPYTE
P
E
E
DFGD
T
K
R
I
------
E
V
M
V
GMGY
T
R
E
E
I
K
E
S
L
T
S
Q
K
Y
N
E
V
T
A
T
Y
L
L
LGRK--TEEGGDRGAPG
L
A
L
A
R
V
RAPSDTTNGTSSSKGTSHSKGQRSSS
S
T
Y
H
R
Q
RRHSDFCGPSPAPLHPKRSPTST
G
E
A
E
L
K
E
ERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNP
N
K
A
EIPERRKDSTSTPNNL
P
P
S
M
M
TRRN
T
Y
V
CTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSG
E
R
S
RLARGST
I
R
STFHGGQ
V
R
DRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRP
T
T
N
L
F
T
K
L
T
S
K
L
T
R
R
VAD
E
P
E
RIGGPEV
T
S
C
HLPWDQTETAP
R
L
L
RF
P
W
S
V
K
LTSSR
P
P
E
A
L
M
A
A
L
R
Q
A
T
A
A
A
RCRCRQPQ
P
F
L
L
A
C
L
HGGAGGPEPLS
H
F
E
V
E
VCQLPRP
G
L
R
G
V
L
F
R
R
VA
G
T
A
L
A
F
R
T
L
V
T
R
I
SNDLEL
543
HHSearch
94.57
70%
-108
- C3 -
-
6C9D
-
MARK1_HUMAN
A:
[16-459]
------------------------------------------------------------
E
----
Q
P
H
----
I
G
N
Y
R
L
Q
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
V
-
L
T
G
R
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
P
-
T
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
Y
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
G
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
-
T
V
-
G
-
N
K
---
L
D
E
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
L
L
V
L
N
P
I
K
R
G
-----
S
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
E
E
E
L
K
P
Y
T
E
P
D
P
D
F
N
D
T
K
R
I
------
D
I
M
V
T
M
G
F
A
R
D
E
I
N
D
A
L
I
N
Q
K
Y
D
E
V
M
A
T
Y
I
L
L
----------------------------------------------------------------------------------------------------------------------------
G
R
K
P
P
E
-
F
E
G
--------------------------------------------------------------------------------------------------------------------------------------------------------
K
P
R
S
L
R
F
T
W
S
M
K
T
T
S
S
M
D
P
N
D
M
M
R
E
I
R
K
V
L
D
A
N
N
C
D
Y
E
Q
K
E
R
F
L
L
F
C
V
H
G
D
A
R
-
Q
D
S
L
V
Q
W
E
M
E
V
C
S
L
P
S
L
S
L
N
G
V
R
F
K
R
I
S
G
T
S
I
A
F
K
N
I
A
S
K
I
A
N
E
L
K
L
1
PsiBlast_PDB
80.85
100%
-120
- C3 -
-
5ES1
1
MARK4_HUMAN
A:
[12-328]
------------------------------------------------------------------
P
H
----
V
G
N
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
R
E
V
A
I
K
I
I
D
K
T
---
Q
-
L
--
N
--
P
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
G
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
-
K
N
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
E
---
A
N
---
I
K
I
A
D
F
G
F
S
---
N
-------------------
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
H
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
V
--
P
F
----
Y
--
M
S
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
C
-----
T
L
E
Q
I
M
K
D
----------
K
W
I
N
I
G
Y
----
E
G
E
E
L
K
P
Y
T
E
P
E
E
D
F
G
D
T
K
R
I
------
E
V
M
V
G
M
G
Y
T
R
E
E
I
K
E
S
L
T
S
Q
K
Y
N
E
V
T
A
T
Y
L
L
L
G
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
80.37
82%
-111
- C3 -
-
6C9D
-
MARK1_HUMAN
A:
[16-410]
------------------------------------------------------------
E
----
Q
P
H
----
I
G
N
Y
R
L
Q
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
V
-
L
T
G
R
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
P
-
T
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
Y
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
G
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
-
T
V
-
G
-
N
K
---
L
D
E
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
L
L
V
L
N
P
I
K
R
G
-----
S
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
E
E
E
L
K
P
Y
T
E
P
D
P
D
F
N
D
T
K
R
I
------
D
I
M
V
T
M
G
F
A
R
D
E
I
N
D
A
L
I
N
Q
K
Y
D
E
V
M
A
T
Y
I
L
L
G
R
K
PP
E
F
E
G
G
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
HHSearch
79.46
86%
-110
- C3 -
-
2QNJ
-
MARK3_HUMAN
B:
[50-367]
-----------------------------------------------------------------
Q
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
R
E
V
A
I
K
I
I
D
K
T
---
Q
-
L
--
N
--
P
-
T
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
-
T
-----
K
---
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
I
N
A
G
H
----
E
E
D
E
L
K
P
F
V
E
P
E
L
D
I
S
D
Q
K
R
I
------
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
I
T
A
T
Y
L
L
L
G
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
78.84
85%
-106
- C3 -
-
2QNJ
-
MARK3_HUMAN
A:
[44-366]
---------------------------------------------------
A
----
M
G
S
-
E
----
Q
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
R
E
V
A
I
K
I
I
D
K
T
---
Q
-
L
--
N
--
P
-
T
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
-
T
----------
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
I
N
A
G
H
----
E
E
D
E
L
K
P
F
V
E
P
E
L
D
I
S
D
Q
K
R
I
------
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
I
T
A
T
Y
L
L
L
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.81
85%
-119
- C3 -
-
3IEC
-
MARK2_HUMAN
A:
[5-318]
-------------------------------------------------------------------
H
----
I
G
N
Y
R
L
L
K
T
I
G
----
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
W
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
-
T
F
-
G
-
N
K
---
L
D
T
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.10
85%
-110
- C- -
-
3FE3
-
MARK3_HUMAN
A:
[50-366]
-----------------------------------------------------------------
Q
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
R
E
V
A
I
K
I
I
D
K
T
---
Q
-
L
--
N
--
P
-
T
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
-
T
V
-
G
-
G
K
---
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
I
N
A
G
H
----
E
E
D
E
L
K
P
F
V
E
P
E
L
D
I
S
D
Q
K
R
I
------
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
I
T
A
T
Y
L
L
L
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
HHSearch
76.37
85%
-111
- C- -
-
3FE3
-
MARK3_HUMAN
B:
[50-366]
-----------------------------------------------------------------
Q
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
R
E
V
A
I
K
I
I
D
K
T
---
Q
-
L
--
N
--
P
-
T
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
R
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
-
T
V
-
G
-
G
K
---
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
I
N
A
G
H
----
E
E
D
E
L
K
P
F
V
E
P
E
L
D
I
S
D
Q
K
R
I
------
D
I
M
V
G
M
G
Y
S
Q
E
E
I
Q
E
S
L
S
K
M
K
Y
D
E
I
T
A
T
Y
L
L
L
G
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
75.81
83%
-99
- C3 -
-
2HAK
-
MARK1_HUMAN
A:
[48-364]
------------------------------------------------------------------
P
H
----
I
G
N
Y
R
L
Q
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
V
-
L
T
G
R
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
P
-
T
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
I
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
Y
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
G
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
---
N
E
F
-
T
V
-------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
L
L
V
L
N
P
I
K
R
G
-----
S
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
E
E
E
L
K
P
Y
T
E
P
D
P
D
F
N
D
T
K
R
I
------
D
I
M
V
T
M
G
F
A
R
D
E
I
N
D
A
L
I
N
Q
K
Y
D
E
V
M
A
T
Y
I
L
L
G
R
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
75.31
83%
-123
- C3 -
-
1ZMW
-
MARK2_RAT
A:
[49-363]
-------------------------------------------------------------------
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
----------------------
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
75.23
84%
-115
- C3 -
-
5EAK
1
MARK2_HUMAN
B:
[15-327]
-------------------------------------------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
----------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
75.14
84%
-118
- C3 -
-
5KZ8
1
MARK2_HUMAN
B:
[30-345]
------------------------------------------------------------------
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
-------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
74.64
84%
-118
- C3 -
-
5KZ8
1
MARK2_HUMAN
A:
[30-345]
------------------------------------------------------------------
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
-----------------------
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.48
81%
-118
- C3 -
-
1Y8G
-
MARK2_RAT
A:
[49-363]
-------------------------------------------------------------------
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
----------------------
L
D
A
F
C
G
A
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
74.43
84%
-105
- C3 -
-
5EAK
1
MARK2_HUMAN
A:
[11-326]
-----------------------------------------------------------------
Q
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
G
F
S
--------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
74.34
83%
-126
- C3 -
-
1ZMV
-
MARK2_RAT
A:
[51-363]
-------------------------------------------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
R
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
74.28
84%
-125
- C3 -
-
5KZ7
1
MARK2_HUMAN
A:
[30-345]
------------------------------------------------------------------
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
-------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
----
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
74.17
84%
-123
- C3 -
-
5KZ7
1
MARK2_HUMAN
B:
[30-345]
------------------------------------------------------------------
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
-------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
--
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
----
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.43
84%
-117
- C3 -
-
1ZMU
-
MARK2_RAT
A:
[51-363]
-------------------------------------------------------------------------
G
N
Y
R
L
L
K
T
I
G
K
G
--
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
---------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.68
83%
-120
- C- -
-
2R0I
-
MARK2_RAT
A:
[48-363]
------------------------------------------------------------------
P
H
----
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
-
L
T
G
K
E
V
A
V
K
I
I
D
K
T
---
Q
-
L
--
N
--
S
-
S
S
L
---
Q
-
K
L
----
F
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
-
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
--
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
---
L
---
D
A
---
D
---
M
N
---
I
K
I
A
D
F
-------------------------
G
S
P
P
Y
A
A
P
E
L
F
Q
G
K
K
Y
D
-----
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
-
G
S
L
P
F
D
--
G
Q
N
L
K
E
L
R
E
R
V
L
R
G
-
K
Y
--
R
I
--
P
F
----
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
L
E
Q
I
M
K
D
----------
R
W
M
N
V
G
H
----
E
D
D
E
L
K
P
Y
V
A
P
L
P
D
Y
K
D
P
R
R
T
------
E
L
M
V
S
M
G
Y
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
HHSearch
63.56
42%
-122
- C3 -
-
5TVT
1
MELK_HUMAN
A:
[7-328]
------------------------------------------------------------------
E
L
----
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
-----
G
-
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-----------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
----
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
------
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
--
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
HHSearch
62.59
42%
-116
- C3 -
-
5K00
1
MELK_HUMAN
A:
[5-326]
------------------------------------------------------------------
E
L
----
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
-----
G
-
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
P
-----------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
----
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
C
V
T
------
E
L
S
V
H
H
R
N
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
--
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
61.14
42%
-122
- C3 -
-
4BFM
1
MELK_MOUSE
A:
[11-311]
---------------------------------------------------------------------------
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
A
-
L
--
G
----
S
D
L
---
P
-
R
V
----
K
T
E
I
D
A
L
K
S
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
N
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
----------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
----------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
E
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
L
L
N
H
----------
P
W
V
M
Q
D
Y
SCPV
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
----
V
T
------
E
L
S
V
H
H
R
S
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
60.42
45%
-140
- C3 -
-
4UMT
2
MELK_HUMAN
A:
[31-305]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
T
A
A
A
L
V
A
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
60.11
42%
-119
- C3 -
-
4CQG
1
MELK_MOUSE
A:
[11-311]
---------------------------------------------------------------------------
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
A
-
L
--
G
----
S
D
L
---
P
-
R
V
----
K
T
E
I
D
A
L
K
S
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
N
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
----------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
----------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
E
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
R
N
L
L
N
H
----------
P
W
V
M
Q
D
Y
SCPV
E
W
Q
S
K
T
P
L
T
H
L
D
E
D
C
----
V
T
------
E
L
S
V
H
H
R
S
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
59.45
45%
-127
- C3 -
-
5TWL
1
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
59.36
44%
-136
- C3 -
-
4UMQ
1
MELK_HUMAN
A:
[31-305]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
T
A
A
A
L
V
A
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
59.20
44%
-140
- C3 -
-
4UMR
1
MELK_HUMAN
A:
[31-305]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
T
A
A
A
L
V
A
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
59.16
45%
-135
- C3 -
-
4UMU
1
MELK_HUMAN
A:
[31-305]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
T
A
A
A
L
V
A
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
58.49
45%
-124
- C3 -
-
5TVT
1
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
-----------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
58.35
45%
-136
- C3 -
-
5TWZ
1
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
58.32
45%
-135
- C3 -
-
5MAI
2
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
--------------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
--
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
57.95
45%
-130
- C3 -
-
4BKY
1
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--------
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
57.86
45%
-129
- C3 -
-
5M5A
1
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
57.75
45%
-136
- C3 -
-
5IHC
1
MELK_HUMAN
A:
[10-284]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
-------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
57.71
45%
-127
- C3 -
-
5MAH
2
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
57.48
45%
-120
- C3 -
-
5K00
1
MELK_HUMAN
A:
[10-284]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--
G
----
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
--
P
---------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
57.24
45%
-132
- C3 -
-
4BKZ
1
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
---------
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
-------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
---------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
57.13
45%
-135
- C3 -
-
5TWY
1
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
----------
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
----------------------
C
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
57.02
45%
-127
- C3 -
-
4BL1
1
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
---------
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
57.00
45%
-123
- C3 -
-
5IH9
1
MELK_HUMAN
A:
[10-284]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-----------
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
56.86
45%
-126
- C3 -
-
5IH8
1
MELK_HUMAN
A:
[10-284]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
----------
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
56.31
45%
-129
- C3 -
-
5IHA
1
MELK_HUMAN
A:
[10-284]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
----
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
---------------
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
S
Y
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
56.26
45%
-139
- C3 -
-
5TX3
2
MELK_HUMAN
A:
[15-289]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
----------------------
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
-----------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
55.78
45%
-125
- C3 -
-
5MAG
3
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--------
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
55.69
45%
-117
- C3 -
-
6GVX
3
MELK_HUMAN
B:
[15-289]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
---------
S
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
--
P
--------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
---------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
55.60
45%
-121
- C3 -
-
5MAF
2
MELK_HUMAN
A:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
---
T
-
L
--------
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
---
A
K
------------------
S
L
A
Y
A
A
P
E
L
I
Q
G
K
--
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
54.84
45%
-134
- C3 -
-
5TX3
2
MELK_HUMAN
B:
[15-289]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
-----
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
----------------------------
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
--------------------------
G
S
L
A
Y
A
A
P
E
L
I
Q
G
---
L
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
53.71
45%
-131
- C3 -
-
5TWY
1
MELK_HUMAN
B:
[12-286]
---------------------------------------------------------------------------
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
-
L
T
G
E
M
V
A
I
K
I
M
D
K
N
--------------
D
L
---
P
-
R
I
----
K
T
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
-
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
--
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
---
F
---
D
E
---
Y
---
H
K
---
L
K
L
I
D
F
G
L
C
------------------------
L
A
Y
A
A
P
E
L
I
Q
G
K
--------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
-
G
F
L
P
F
D
--
D
D
N
V
M
A
L
Y
K
K
I
M
R
G
-
K
Y
--
D
V
--
P
K
----
W
--
L
S
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
M
K
N
L
L
N
H
----------
P
W
I
M
Q
D
Y
NYPV
E
W
Q
S
K
N
P
F
I
H
L
D
D
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
53.36
38%
-87
- C3 -
-
3BHH
1
KCC2B_HUMAN
B:
[6-264]
---------------------------------------------------------------------------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
-
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
CKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
-----
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
H
E
A
L
K
H
----------
P
W
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
53.35
46%
-47
- C3 -
-
6C9H
2
AAPK1_HUMAN
A:
[13-330]
------------------------------------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
R-
S
--
L
-
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
53.29
38%
-79
- C3 -
-
6AYW
2
KCC2D_HUMAN
A:
[15-273]
---------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
53.29
38%
-74
- C3 -
-
6AYW
2
KCC2D_HUMAN
B:
[15-273]
---------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
53.27
38%
-85
- C3 -
-
3BHH
1
KCC2B_HUMAN
A:
[6-264]
---------------------------------------------------------------------------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
-
C
T
G
H
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
S
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
-
M
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
CKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
E
A
Y
G
-----
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
K
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
A
H
E
A
L
K
H
----------
P
W
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
53.12
34%
-141
- C3 -
-
3W18
1
AURKA_HUMAN
B:
[2-258]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
-----------------------
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
-----------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
53.12
38%
-76
- C3 -
-
5VLO
2
KCC2D_HUMAN
B:
[15-273]
---------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
52.94
34%
-142
- C3 -
-
3W18
1
AURKA_HUMAN
A:
[2-258]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
--
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
--------------
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
---------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
52.91
38%
-82
- C3 -
-
5VLO
2
KCC2D_HUMAN
A:
[15-273]
---------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
---
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
52.85
38%
-71
- C3 -
-
5FG8
3
KCC2A_DROME
A:
[15-274]
--------------------------------------------------------------------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
-
S
T
G
F
E
F
A
A
K
I
I
N
T
K
---
K
-
L
--
T
--
A
-
R
D
F
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
-
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
-
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
---
A
K
GAA
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
H
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
------
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
S
Q
I
K
A
G
-
A
Y
--
D
Y
--
P
S
PEWD
T
--
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
52.82
38%
-78
- C3 -
-
2WEL
7
KCC2D_HUMAN
A:
[6-268]
---------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
52.75
38%
-71
- C3 -
-
2VN9
2
KCC2D_HUMAN
A:
[6-264]
---------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
52.75
38%
-68
- C3 -
-
5HU3
1
KCC2A_DROME
A:
[15-274]
--------------------------------------------------------------------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
-
S
T
G
F
E
F
A
A
K
I
I
N
T
K
---
K
-
L
--
T
--
A
-
R
D
F
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
-
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
-
N
G
V
V
H
R
N
L
K
P
E
N
L
L
---
L
---
A
S
---
K
---
A
K
GAA
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
H
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
------
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
S
Q
I
K
A
G
-
A
Y
--
D
Y
--
P
S
PEWD
T
--
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
52.42
38%
-72
- C3 -
-
2VN9
1
KCC2D_HUMAN
B:
[6-264]
---------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
52.39
38%
-74
- C3 -
-
6BAB
1
KCC2D_MOUSE
D:
[15-273]
---------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
52.22
38%
-74
- C3 -
-
6BAB
2
KCC2D_MOUSE
A:
[15-273]
---------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
51.70
38%
-76
- C3 -
-
6BAB
2
KCC2D_MOUSE
B:
[15-273]
---------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
----
S
V
V
R
R
C
M
K
I
-
P
T
G
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
51.48
38%
-72
- C3 -
-
6BAB
2
KCC2D_MOUSE
C:
[15-273]
---------------------------------------------------------------------------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
-----
Q
E
Y
A
A
K
I
I
N
T
K
---
K
-
L
--
S
--
A
-
R
D
H
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
-
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
SKG
A
A
---
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
Q
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
R
K
D
P
Y
G
-----
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
Q
Q
I
K
A
G
-
A
Y
--
D
F
--
P
S
PEWD
T
--
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
A
S
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
51.33
38%
-65
- C3 -
-
5H9B
2
KCC2A_DROME
A:
[15-274]
--------------------------------------------------------------------------
N
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
-
S
T
G
F
E
F
A
A
K
I
I
N
T
K
---
K
-
L
--
T
--
A
-
R
D
F
---
Q
-
K
L
----
E
R
E
A
R
I
C
R
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
-
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
--
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
-
N
G
V
V
H
R
D
L
K
P
E
N
L
L
---
L
---
A
S
---
K
---
A
K
GAA
V
K
L
A
D
F
G
L
A
---
I
E
V
-
Q
G
-
D
-
H
Q
A--
W
F
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
K
K
E
P
Y
------
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
-
G
Y
P
P
F
W
--
D
E
D
Q
H
R
L
Y
S
Q
I
K
A
G
-
A
Y
--
D
Y
--
P
S
PEWD
T
--
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
A
A
E
A
L
K
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
50.94
45%
-42
- C3 -
-
4REW
1
AAPK1_HUMAN
A:
[5-401]
------------------------------------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
R-
S
--
L
-
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
50.36
46%
-52
- C3 -
-
3AQV
1
AAPK2_HUMAN
A:
[10-276]
------------------------------------------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
R-
S
--
L
-
D
V
V
---
G
-
K
I
----
K
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
--
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
------
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
E
H
V
P
T
L
F
K
K
I
R
G
G
-
V
F
--
Y
I
--
P
E
----
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
S
Y
L
F
P
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
50.20
33%
-23
- C3 -
-
2F7X
1
KAPCA_BOVIN
E:
[40-343]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
---
V
-
K
-
G
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
------
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
49.97
40%
-65
- C3 -
-
4IEB
1
?
A:
[51-310]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
-------
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
---
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
49.59
36%
-66
- C3 -
-
1ZLT
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
49.47
38%
-69
- C3 -
-
3IGO
8
?
A:
[24-295]
---------------------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
-
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
-
A
--
K
--
N
-
K
-
T
---
S
-
T
I
----
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
-
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
--
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
-
Q
Q
-
N
-
T
----------
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
-
K
Y
--
A
F
--
D
L
PQWR
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
49.45
36%
-68
- C3 -
-
2BR1
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
49.34
36%
-70
- C3 -
-
2BRO
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
49.29
39%
-86
- C3 -
-
4FG7
1
KCC1A_HUMAN
A:
[20-276]
---------------------------------------------------------------------------
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
-
R
T
Q
K
L
V
A
I
K
C
I
A
-----------------------
S
M
----
E
N
E
I
A
V
L
H
K
I
K
-
H
P
N
I
V
A
L
D
D
I
Y
-
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
-
L
G
I
V
H
R
D
L
K
P
E
N
L
L
YYS
L
---
D
E
---
D
---
S
K
---
I
M
I
S
D
F
G
L
S
---
K
M
E
-
D
P
-------------
G
T
P
G
Y
V
A
P
E
V
L
A
Q
K
--------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-
G
Y
P
P
F
Y
--
D
E
N
D
A
K
L
F
E
Q
I
L
K
A
-
E
Y
--
E
F
DS
P
Y
----
W
DD
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
C
E
Q
A
L
Q
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
49.33
33%
-23
- C3 -
-
2UZT
1
KAPCA_BOVIN
A:
[25-328]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
---
V
-
K
-
G
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
D
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
------
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
49.31
38%
-70
- C3 -
-
3MWU
1
?
A:
[24-300]
---------------------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
-
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
-
A
--
K
--
N
-
K
D
T
---
S
-
T
I
----
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
-
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
--
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
-
Q
Q
-
N
--------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
-
K
Y
--
A
F
--
D
L
PQWR
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
49.29
36%
-69
- C3 -
-
2HY0
1
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
49.17
36%
-68
- C3 -
-
4HYI
4
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-------
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
49.15
36%
-69
- C3 -
-
4HYH
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
49.07
36%
-67
- C3 -
-
3NLB
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
---------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
49.04
36%
-69
- C3 -
-
2CGW
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-------
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
49.01
36%
-72
- C3 -
-
4FTI
3
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
48.96
33%
-22
- C3 -
-
2OH0
1
KAPCA_BOVIN
E:
[40-343]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
---
V
-
K
-
G
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
------
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
48.95
36%
-66
- C3 -
-
2CGV
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
48.94
36%
-69
- C3 -
-
4QYG
1
CHK1_HUMAN
B:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
48.92
33%
-22
- C3 -
-
2F7E
1
KAPCA_BOVIN
E:
[40-343]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
---
V
-
K
-
G
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
------
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
48.92
33%
-25
- C3 -
-
2OJF
1
KAPCA_BOVIN
E:
[40-343]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
---
V
-
K
-
G
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
------
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
48.91
36%
-71
- C3 -
-
2HOG
1
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
48.89
36%
-67
- C3 -
-
2HXL
1
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
48.90
33%
-26
- C3 -
-
2F7Z
1
KAPCA_BOVIN
E:
[40-343]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
---
V
-
K
-
G
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
------
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
48.89
46%
-68
- C3 -
-
6BX6
1
AAPK2_HUMAN
A:
[10-274]
------------------------------------------------------------------------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
R-
S
--
L
-
D
V
V
---
G
-
K
I
----
K
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
--
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
-------------------------
N
Y
A
A
P
E
------
Y
A
-----
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
E
H
V
P
T
L
F
K
K
I
R
G
G
-
V
F
--
Y
I
--
P
E
----
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
S
Y
L
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
48.83
36%
-66
- C3 -
-
4QYG
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
48.82
36%
-72
- C3 -
-
4FSR
1
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
48.75
36%
-74
- C3 -
-
3OT3
1
CHK1_HUMAN
A:
[4-265]
-------------------------------------------------------------------
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
48.80
36%
-71
- C3 -
-
1NVQ
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
48.75
36%
-71
- C3 -
-
3TKI
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
48.70
36%
-64
- C3 -
-
2HXQ
1
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
48.66
36%
-69
- C3 -
-
4QYH
1
CHK1_HUMAN
B:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
48.66
36%
-69
- C3 -
-
4RVK
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
48.66
38%
-70
- C3 -
-
3NCG
1
?
A:
[24-317]
---------------------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
-
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
-
A
--
K
--
N
-
K
D
T
---
S
-
T
I
----
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
-
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
--
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
-
Q
Q
-
N
-
T
--------
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
-
K
Y
--
A
F
--
D
L
PQWR
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
48.59
36%
-67
- C3 -
-
2BRB
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
48.59
36%
-71
- C3 -
-
4QYH
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
48.53
36%
-71
- C3 -
-
4QYE
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
48.55
33%
-24
- C3 -
-
2UZW
1
KAPCA_BOVIN
E:
[25-328]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
---
V
-
K
-
G
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
D
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
------
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
48.54
36%
-77
- C3 -
-
4FTU
4
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
48.53
33%
-17
- C3 -
-
2UZV
1
KAPCA_BOVIN
A:
[25-328]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
---
V
-
K
-
G
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
D
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
------
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
48.48
36%
-66
- C3 -
-
2X8I
2
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
48.46
36%
-71
- C3 -
-
4RVM
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
48.43
36%
-66
- C3 -
-
2C3K
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
48.38
36%
-70
- C3 -
-
2R0U
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
48.31
36%
-69
- C3 -
-
2BRN
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
48.31
36%
-70
- C3 -
-
2CGU
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
48.24
36%
-66
- C3 -
-
2BRM
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
48.26
36%
-72
- C3 -
-
4FT9
1
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
48.24
38%
-48
- C3 -
-
2WEI
1
?
A:
[24-286]
---------------------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
-
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
-
A
--
K
--
N
-
K
D
T
---
S
-
T
I
----
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
-
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
--
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
-
Q
Q
-
N
-
T
K
---
M
K
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
-
K
Y
--
A
F
--
D
L
PQWR
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
----------
P
W
I
Q
-
K
Y
----
S
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
48.15
36%
-71
- C3 -
-
1NVR
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
48.11
36%
-68
- C3 -
-
2C3J
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
---------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
48.11
36%
-66
- C3 -
-
2CGX
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
561
HHSearch
48.14
36%
-35
- C3 -
-
4GV1
5
AKT1_HUMAN
A:
[7-276]
------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
-
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
---
V
-
I
V-
A
--
K
-
D
E
V
---
A
-
H
T
----
L
T
E
N
R
V
L
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
-
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
--
V
-
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
---
L
---
D
K
---
D
---
G
H
---
I
K
I
T
D
F
G
L
C
---
K
E
G
-
I
K
-
D
G
A
T
---
M
K
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
D
Y
G
------
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
-
G
R
L
P
F
Y
--
N
Q
D
H
E
K
L
F
E
L
I
L
M
E
-
E
I
--
R
F
--
P
R
----
T
--
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
L
GGGSE
D
A
K
E
I
M
Q
H
----------
R
F
F
A
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
48.12
36%
-68
- C3 -
-
2BRG
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
-------------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
48.11
36%
-71
- C3 -
-
2QHM
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
48.10
43%
-19
- C3 -
-
4CZT
4
CIPKN_ARATH
D:
[10-278]
------------------------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
--
N
-
K
M
I
---
A
-
Q
I
----
K
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
-
R
E
-
D
-
G
L
---
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
C
--
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
48.09
36%
-70
- C3 -
-
4FT0
2
CHK1_HUMAN
A:
[3-269]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
---------------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
48.07
36%
-74
- C3 -
-
5F4N
8
CHK1_HUMAN
A:
[5-266]
-------------------------------------------------------------------
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
48.04
36%
-63
- C3 -
-
2YDK
6
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
---------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
47.98
36%
-67
- C3 -
-
4QYF
1
CHK1_HUMAN
A:
[4-268]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
47.90
36%
-74
- C3 -
-
3PA3
1
CHK1_HUMAN
A:
[4-265]
-------------------------------------------------------------------
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
47.94
36%
-77
- C3 -
-
3TKH
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
-----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
47.91
36%
-71
- C3 -
-
4FT7
4
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
47.90
36%
-70
- C3 -
-
2C3L
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-----------
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
47.84
34%
-56
- C3 -
-
2W1E
1
AURKA_HUMAN
A:
[7-264]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
47.86
35%
-54
- C3 -
-
3D2I
1
AURKA_MOUSE
A:
[8-265]
-----------------------------------------------------------------
Q
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
47.84
36%
-69
- C3 -
-
1NVS
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
47.83
36%
-69
- C3 -
-
2QHN
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
47.80
36%
-74
- C3 -
-
4RVL
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
47.75
36%
-77
- C3 -
-
4FTL
2
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
-----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
47.75
38%
-66
- C3 -
-
4Y5Q
1
?
A:
[24-300]
---------------------------------------------------------------------------
Y
N
I
V
C
M
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
-
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
A
---
S
-
A
--
K
--
N
-
K
D
T
---
S
-
T
I
----
L
R
E
V
E
L
L
K
K
L
D
-
H
P
N
I
M
K
L
F
E
I
L
-
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
--
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
E
S
KEK
D
---
C
D
---
I
K
I
I
D
F
G
L
S
---
T
C
F
-
Q
Q
-
N
-
T
------
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
R
G
-
T
Y
D
------
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
-
G
T
P
P
F
Y
--
G
K
N
E
Y
D
I
L
K
R
V
E
T
G
-
K
Y
--
A
F
--
D
L
PQWR
T
--
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
A
T
Q
C
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
47.69
34%
-50
- C3 -
-
4DEA
4
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
47.68
35%
-64
- C3 -
-
3D2K
1
AURKA_MOUSE
A:
[9-265]
------------------------------------------------------------------
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
------------------
T
L
D
Y
L
P
P
E
M
I
-----
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
47.59
36%
-64
- C3 -
-
2GDO
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
--------
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
47.59
43%
-26
- C3 -
-
4CZT
3
CIPKN_ARATH
C:
[10-274]
------------------------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
--
N
-
K
M
I
---
A
-
Q
I
----
K
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
-
R
E
-
D
-
G
L
---
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
C
--
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
47.57
36%
-70
- C3 -
-
4FSN
2
CHK1_HUMAN
A:
[2-264]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
47.56
35%
-55
- C3 -
-
3DJ5
1
AURKA_MOUSE
A:
[9-265]
------------------------------------------------------------------
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
-------------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
47.55
36%
-75
- C3 -
-
4FTK
2
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
-----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
47.54
36%
-73
- C3 -
-
4FTJ
3
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
------------------
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
47.53
35%
-53
- C3 -
-
3D15
1
AURKA_MOUSE
A:
[8-265]
-----------------------------------------------------------------
Q
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-----------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
47.52
35%
-53
- C3 -
-
3DJ7
1
AURKA_MOUSE
A:
[8-265]
-----------------------------------------------------------------
Q
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
47.49
34%
-59
- C3 -
-
2W1D
1
AURKA_HUMAN
A:
[7-264]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
-------
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
47.43
42%
-20
- C3 -
-
4CZU
3
CIPKN_ARATH
D:
[10-278]
------------------------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
--
N
-
K
M
I
---
A
-
Q
I
----
K
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
-
R
E
-
D
-
G
L
---
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
C
--
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
47.38
35%
-51
- C3 -
-
3D14
1
AURKA_MOUSE
A:
[8-265]
-----------------------------------------------------------------
Q
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
47.36
36%
-68
- C3 -
-
2XEY
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
---------------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
47.31
35%
-53
- C3 -
-
3DJ6
1
AURKA_MOUSE
A:
[9-265]
------------------------------------------------------------------
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
-------------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
47.25
36%
-73
- C3 -
-
4FSM
3
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
-----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
47.20
36%
-69
- C3 -
-
2X8E
1
CHK1_HUMAN
A:
[9-266]
---------------------------------------------------------------------------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
----
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
47.14
36%
-72
- C3 -
-
2YM4
4
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
-----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
-------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
47.16
40%
-62
- C3 -
-
3HX4
3
?
A:
[52-310]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
---------------
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
47.15
34%
-48
- C3 -
-
4DHF
1
AURKA_HUMAN
B:
[8-264]
------------------------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
47.14
33%
-19
- C3 -
-
2UZU
1
KAPCA_BOVIN
E:
[25-328]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
---
V
-
K
-
G
R
---
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
D
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
------
D
-----
D
Y
E
E
E
E
I
R
V
S
I
N
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
47.09
36%
-71
- C3 -
-
2BRH
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
47.12
34%
-52
- C3 -
-
6C2T
2
AURKA_HUMAN
A:
[9-265]
------------------------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
---------------
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
47.09
34%
-48
- C3 -
-
3UOD
3
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
47.08
42%
-26
- C3 -
-
4CZU
3
CIPKN_ARATH
A:
[10-279]
------------------------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
--
N
-
K
M
I
---
A
-
Q
I
----
K
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
-
R
E
-
D
-
G
L
---
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
C
--
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
47.05
34%
-44
- C3 -
-
5G15
1
AURKA_HUMAN
A:
[6-262]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
46.94
36%
-73
- C3 -
-
4JIK
1
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
------------------
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
46.99
34%
-54
- C3 -
-
5DR9
2
AURKA_HUMAN
A:
[4-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
46.96
36%
-75
- C3 -
-
4FT5
2
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
46.94
34%
-57
- C3 -
-
3MYG
2
AURKA_HUMAN
A:
[8-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
46.93
36%
-70
- C3 -
-
5DLS
1
CHK1_HUMAN
A:
[6-266]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
46.92
34%
-46
- C3 -
-
2J4Z
2
AURKA_HUMAN
B:
[30-286]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
46.85
34%
-47
- C3 -
-
4DEB
3
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
46.83
34%
-55
- C3 -
-
3NRM
1
AURKA_HUMAN
A:
[7-263]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
A
A
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
46.81
36%
-75
- C3 -
-
2WMV
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
46.79
34%
-56
- C3 -
-
3VAP
1
AURKA_HUMAN
A:
[8-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
-----------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
46.79
34%
-51
- C3 -
-
2WTW
1
AURKA_HUMAN
A:
[10-265]
------------------------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
46.78
43%
-22
- C3 -
-
4CZT
3
CIPKN_ARATH
A:
[10-276]
------------------------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
--
N
-
K
M
I
---
A
-
Q
I
----
K
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
-
R
E
-
D
-
G
L
---
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
C
--
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
46.75
36%
-75
- C3 -
-
4FTM
5
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
-----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
46.67
36%
-65
- C3 -
-
3U9N
1
CHK1_HUMAN
A:
[6-265]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
---------------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
46.72
42%
-23
- C3 -
-
4CZU
3
CIPKN_ARATH
C:
[10-279]
------------------------------------------------------------------------
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
-
E
N
G
D
N
V
A
I
K
V
I
D
K
E
---
K
V
L
--
K
--
N
-
K
M
I
---
A
-
Q
I
----
K
R
E
I
S
T
M
K
L
I
K
-
H
P
N
V
I
R
M
F
E
V
M
-
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
--
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
-
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
---
L
---
D
A
---
N
---
G
A
---
L
K
V
S
D
F
G
L
S
ALP
Q
Q
V
-
R
E
-
D
-
G
L
---
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
N
N
K
G
Y
D
-----
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
-
G
Y
L
P
F
E
--
D
S
N
L
T
S
L
Y
K
K
I
F
K
A
-
E
F
--
T
C
--
P
P
----
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
F
A
E
V
I
E
N
----------
E
W
F
K
K
G
Y
----
K
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
46.67
34%
-44
- C3 -
-
3UO6
3
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
46.66
34%
-60
- C3 -
-
4C3P
1
AURKA_HUMAN
A:
[6-262]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
46.64
36%
-72
- C3 -
-
3PA4
4
CHK1_HUMAN
A:
[5-265]
------------------------------------------------------------------------
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
46.62
34%
-55
- C3 -
-
2XNG
1
AURKA_HUMAN
A:
[7-263]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
---------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
46.59
34%
-46
- C3 -
-
4JAJ
1
AURKA_HUMAN
A:
[15-271]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
46.56
33%
-61
- C3 -
-
6CPG
1
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
----------------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
46.55
36%
-75
- C3 -
-
2YM6
6
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
----------------
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
46.48
34%
-54
- C3 -
-
3R21
1
AURKA_HUMAN
A:
[7-264]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
----------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
46.48
33%
-48
- C3 -
-
6CPF
1
AURKA_HUMAN
A:
[10-265]
------------------------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
---------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
46.43
34%
-46
- C3 -
-
4DHF
1
AURKA_HUMAN
A:
[8-264]
------------------------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
46.41
34%
-53
- C3 -
-
4BYI
1
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
--------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
46.39
36%
-73
- C3 -
-
4FSQ
1
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
------------------
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
46.37
34%
-43
- C3 -
-
3UOH
4
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
46.32
34%
-51
- C3 -
-
5DR6
2
AURKA_HUMAN
A:
[4-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
46.35
36%
-71
- C3 -
-
4FTT
4
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
46.34
36%
-73
- C3 -
-
4FTR
3
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
--
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
----------------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
46.32
34%
-46
- C3 -
-
3R22
1
AURKA_HUMAN
A:
[7-264]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
--------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
46.31
34%
-46
- C3 -
-
3UP2
3
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
46.27
34%
-47
- C3 -
-
5OBJ
2
AURKA_HUMAN
A:
[8-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
46.26
34%
-39
- C3 -
-
3UOL
6
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
46.26
39%
-59
- C3 -
-
3LIJ
1
?
A:
[39-301]
---------------------------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
-
V
T
H
V
E
R
A
I
K
I
I
R
K
--------------
S
S
N
---
S
-
K
L
----
L
E
E
V
A
V
L
K
L
L
D
-
H
P
N
I
M
K
L
Y
D
F
F
-
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
--
K
-
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KEK
D
---
A
L
---
I
K
I
V
D
F
G
L
S
---
A
V
F
-
E
N
-
Q
-
K
K
---
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
------
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
-
G
Y
P
P
F
G
--
G
Q
T
D
Q
E
I
L
R
K
V
E
K
G
-
K
Y
--
T
F
DS
P
E
----
W
KN
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
-----
S
A
Q
Q
A
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
46.26
35%
-59
- C3 -
-
3DAJ
1
AURKA_MOUSE
A:
[8-265]
-----------------------------------------------------------------
Q
W
T
----
L
E
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
R
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
T
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
R
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
N
---
G
E
---
L
K
I
A
D
F
G
W
S
-----------------------
T
L
D
Y
L
P
P
E
M
I
----
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
E
--
A
H
T
Y
Q
E
T
Y
R
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
L
-----
T
L
A
E
V
L
E
H
----------
P
W
I
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
46.25
34%
-49
- C3 -
-
3UO5
1
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
46.23
34%
-51
- C3 -
-
5DT0
1
AURKA_HUMAN
A:
[4-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
--------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
46.18
34%
-39
- C3 -
-
3UOL
8
AURKA_HUMAN
B:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
46.18
34%
-45
- C3 -
-
4DEE
1
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
46.12
34%
-55
- C3 -
-
2XRU
1
AURKA_HUMAN
A:
[4-260]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
-----------------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
46.12
34%
-51
- C3 -
-
4UZD
1
AURKA_HUMAN
A:
[4-260]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
---------------
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
46.13
34%
-55
- C3 -
-
2C6E
1
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
----------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
46.12
34%
-49
- C3 -
-
4C3R
1
AURKA_HUMAN
A:
[6-262]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
46.11
34%
-64
- C3 -
-
4C3P
1
AURKA_HUMAN
D:
[6-262]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-----------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
46.04
34%
-50
- C3 -
-
5DPV
2
AURKA_HUMAN
A:
[4-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
----------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
46.08
34%
-43
- C3 -
-
3UO6
3
AURKA_HUMAN
B:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
46.04
34%
-43
- C3 -
-
3UOK
1
AURKA_HUMAN
B:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
46.03
34%
-47
- C3 -
-
5DR2
2
AURKA_HUMAN
A:
[4-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
A
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
46.00
34%
-49
- C3 -
-
4UZD
1
AURKA_HUMAN
B:
[4-260]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
--------------
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
45.99
34%
-44
- C3 -
-
3UOK
1
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
45.98
34%
-43
- C3 -
-
3UOH
3
AURKA_HUMAN
B:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
45.91
36%
-76
- C3 -
-
3PA5
4
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
45.96
40%
-35
- C3 -
-
4ONA
1
?
A:
[28-286]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
45.96
40%
-36
- C3 -
-
6BFA
1
?
A:
[28-286]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
45.95
36%
-74
- C3 -
-
2XF0
5
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
45.94
34%
-48
- C3 -
-
4ZTR
1
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
-----------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
45.91
36%
-67
- C3 -
-
2WMR
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
45.92
34%
-41
- C3 -
-
3UNZ
3
AURKA_HUMAN
B:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
45.91
34%
-45
- C3 -
-
2X6D
1
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
----------
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
-------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
45.90
34%
-53
- C3 -
-
6C2R
1
AURKA_HUMAN
A:
[9-265]
------------------------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
-------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
45.89
34%
-40
- C3 -
-
2J4Z
3
AURKA_HUMAN
A:
[30-286]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
45.81
34%
-56
- C3 -
-
6GRA
1
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
45.80
40%
-31
- C3 -
-
5W80
1
?
A:
[28-297]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
45.75
34%
-45
- C3 -
-
1MQ4
1
AURKA_HUMAN
A:
[8-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
-----
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
45.71
34%
-151
- C3 -
-
3W2C
1
AURKA_HUMAN
C:
[5-257]
--------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-------------------------
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
-----------
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
---------------------------
T
L
D
Y
L
P
P
E
M
I
E
-------------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
--
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
----------------
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
45.75
34%
-55
- C3 -
-
4ZTQ
2
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
45.74
34%
-50
- C3 -
-
5OBR
2
AURKA_HUMAN
A:
[8-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
-----------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
45.72
40%
-32
- C3 -
-
4IH8
1
?
A:
[51-337]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
-SK-
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
45.71
34%
-50
- C3 -
-
5ONE
1
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
---------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
45.70
40%
-32
- C3 -
-
4MXA
1
?
A:
[29-293]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
45.69
34%
-59
- C3 -
-
4JAI
1
AURKA_HUMAN
A:
[15-271]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
--------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
45.67
34%
-43
- C3 -
-
3UOJ
1
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
45.64
34%
-50
- C3 -
-
5DRD
1
AURKA_HUMAN
A:
[4-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
--------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
45.63
34%
-48
- C3 -
-
4DED
4
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
45.62
36%
-73
- C3 -
-
2WMX
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
45.61
34%
-45
- C3 -
-
3UP7
1
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
45.60
34%
-48
- C3 -
-
5DOS
2
AURKA_HUMAN
A:
[4-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
--------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
45.59
34%
-57
* C3 *
-
1OL6
1
AURKA_HUMAN
A:
[7-262]
------------------------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
-
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
-----
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
N
F
G
W
S
---
V
H
------------------
T
L
D
Y
L
P
P
E
M
I
E
G
-
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
45.57
34%
-41
- C3 -
-
3UOJ
1
AURKA_HUMAN
B:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
45.56
34%
-42
- C3 -
-
3UNZ
3
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
45.56
40%
-33
- C3 -
-
4YJN
1
?
A:
[28-291]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
45.53
34%
-150
- C3 -
-
3W2C
1
AURKA_HUMAN
E:
[5-257]
--------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-------------------------
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
-----------
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
---------------------------
T
L
D
Y
L
P
P
E
M
I
E
-------------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
--
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
----------------
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
45.48
34%
-50
- C3 -
-
4O0S
1
AURKA_HUMAN
A:
[6-262]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
45.48
33%
-52
- C3 -
-
6CPG
1
AURKA_HUMAN
D:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
--------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
45.48
40%
-33
- C3 -
-
5W91
1
?
A:
[28-300]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
45.47
36%
-74
- C3 -
-
2WMT
1
CHK1_HUMAN
A:
[8-266]
--------------------------------------------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
45.46
40%
-33
- C3 -
-
3HZT
9
?
A:
[6-295]
---------------------------------------------------------------------------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
-
L
T
G
A
E
R
A
I
K
I
I
K
K
S
---
S
-
V
--
T
--
T
-
T
S
N
---
S
G
A
L
----
L
D
E
V
A
V
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
--
K
-
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
-
H
N
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSR
D
---
A
L
---
I
K
I
V
D
F
G
L
S
---
A
H
F
-
E
V
-------------
G
T
A
Y
Y
I
A
P
E
V
L
R
-
K
K
Y
D
------
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
-
G
Y
P
P
F
G
--
G
Q
T
D
Q
E
I
L
K
R
V
E
K
G
-
K
F
--
S
F
DP
P
D
----
W
TQ
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
-----
S
A
E
E
A
L
N
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
45.45
34%
-47
- C3 -
-
5DT4
2
AURKA_HUMAN
A:
[4-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
--------
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
45.37
36%
-75
- C3 -
-
4FTO
4
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
----------------
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
45.37
34%
-57
- C3 -
-
2J50
1
AURKA_HUMAN
A:
[5-260]
------------------------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
---------------
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
----
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
45.34
36%
-76
- C3 -
-
3OT8
4
CHK1_HUMAN
A:
[4-265]
-------------------------------------------------------------------
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
45.31
34%
-70
- C3 -
-
3O51
1
AURKA_HUMAN
A:
[3-260]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
---------------------------
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
45.31
32%
-52
- C3 -
-
4B8L
1
AUKBA_XENLA
A:
[11-268]
-----------------------------------------------------------------
K
F
T
----
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
---
Q
-
L
--
E
--
K
-
E
G
V
---
E
H
Q
L
----
R
R
E
I
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
M
Y
N
Y
F
-
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
--
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
--------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
------
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
D
--
S
P
S
H
T
E
T
H
R
R
I
V
N
V
-
D
L
--
K
F
--
P
P
----
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
V
M
E
H
----------
P
W
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
45.29
40%
-34
- C3 -
-
4MX9
1
?
A:
[29-293]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
45.29
40%
-25
- C3 -
-
3MA6
1
?
A:
[34-292]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
--
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
45.28
34%
-53
- C3 -
-
4ZS0
1
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
-----
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
45.25
34%
-54
- C3 -
-
1MUO
1
AURKA_HUMAN
A:
[22-277]
------------------------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
--------------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
45.26
40%
-34
- C3 -
-
3T3U
5
?
A:
[28-297]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
45.25
40%
-34
- C3 -
-
4M84
1
?
A:
[28-286]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
45.24
34%
-51
- C3 -
-
4ZTS
2
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
-----------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
45.22
40%
-34
- C3 -
-
4WG5
1
?
A:
[28-286]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
45.17
34%
-55
- C3 -
-
2X81
1
AURKA_HUMAN
A:
[8-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
---
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
---------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
45.14
36%
-74
- C3 -
-
2YM8
10
CHK1_HUMAN
A:
[8-266]
--------------------------------------------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
-----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
45.14
34%
-55
- C3 -
-
3W16
1
AURKA_HUMAN
A:
[2-258]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
----------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
45.15
34%
-148
- C3 -
-
3W2C
1
AURKA_HUMAN
A:
[5-257]
--------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-------------------------
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
----------
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
---------------------------
T
L
D
Y
L
P
P
E
M
I
E
-------------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
--
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
----------------
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
45.14
34%
-41
- C3 -
-
3UO4
4
AURKA_HUMAN
A:
[5-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
---
R
D
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
45.10
40%
-32
- C3 -
-
3SXF
3
?
A:
[28-297]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
45.08
34%
-57
- C3 -
-
2J50
1
AURKA_HUMAN
B:
[5-260]
------------------------------------------------------------------
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
---------------
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
----
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
45.06
40%
-35
- C3 -
-
3UPX
1
?
A:
[28-305]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
45.05
36%
-73
- C3 -
-
2YM3
6
CHK1_HUMAN
A:
[8-266]
--------------------------------------------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
45.02
36%
-74
- C3 -
-
2YM5
2
CHK1_HUMAN
A:
[8-266]
--------------------------------------------------------------------------
D
W
D
L
V
Q
T
L
G
-----
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
44.97
40%
-34
- C3 -
-
3KU2
1
?
A:
[51-316]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
44.92
34%
-142
- C3 -
-
3W2C
1
AURKA_HUMAN
G:
[5-257]
--------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-------------------------
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
-----------
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
---------------------------
T
L
D
Y
L
P
P
E
M
I
E
-------------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
--
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
----------------
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
44.90
34%
-56
- C3 -
-
3O50
1
AURKA_HUMAN
A:
[3-260]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
------------------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
44.92
40%
-34
- C3 -
-
3V5P
1
?
A:
[28-301]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
44.90
36%
-74
- C3 -
-
2WMW
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
44.89
36%
-77
- C3 -
-
2YM7
5
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
-----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
44.87
34%
-57
- C3 -
-
3EFW
1
AURKA_HUMAN
A:
[132-383]
--------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
---------------------------
L
D
Y
L
P
P
E
M
I
-----------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
44.87
40%
-30
- C3 -
-
5W9R
1
?
A:
[28-305]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
44.80
40%
-37
- C3 -
-
3T3V
2
?
A:
[28-296]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
44.77
33%
-56
- C3 -
-
6C83
1
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
-------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
44.76
34%
-56
- C3 -
-
3EFW
1
AURKA_HUMAN
B:
[132-383]
--------------------------------------------------------------------------
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
---------------------------
L
D
Y
L
P
P
E
M
I
E
----------
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
44.76
40%
-30
- C3 -
-
5JMS
2
?
A:
[69-344]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
44.71
36%
-67
- C3 -
-
2WMQ
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
---------
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
44.62
34%
-52
- C3 -
-
4B0G
1
AURKA_HUMAN
A:
[7-263]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
---------
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
-------------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
44.62
34%
-61
- C3 -
-
2X6E
1
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
------------------
T
L
D
Y
L
P
P
E
M
I
E
---
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
44.60
40%
-30
- C3 -
-
5T6K
1
?
A:
[69-358]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
---
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
44.55
40%
-34
- C3 -
-
4WG4
1
?
A:
[28-297]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
44.52
36%
-71
- C3 -
-
2XEZ
7
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
44.48
40%
-28
- C3 -
-
5JN2
1
?
A:
[69-342]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
44.46
33%
-50
- C3 -
-
6C83
1
AURKA_HUMAN
B:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
-------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
44.46
40%
-32
- C3 -
-
3I7B
4
?
A:
[28-289]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
44.41
34%
-48
- C3 -
-
2C6E
1
AURKA_HUMAN
B:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
--------------------------
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
44.37
36%
-70
- C3 -
-
2WMS
1
CHK1_HUMAN
A:
[7-266]
-------------------------------------------------------------------------
E
D
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
------------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
44.37
34%
-50
- C3 -
-
4BYJ
1
AURKA_HUMAN
A:
[9-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
---------------------------
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
44.36
40%
-32
- C3 -
-
3MA6
1
?
B:
[34-292]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
----
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
44.27
40%
-30
- C3 -
-
5T6A
1
?
A:
[69-358]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
---
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
44.15
34%
-55
- C3 -
-
3O50
1
AURKA_HUMAN
B:
[3-260]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
---------------------
T
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
----
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
44.15
36%
-78
- C3 -
-
2WMU
1
CHK1_HUMAN
A:
[9-266]
---------------------------------------------------------------------------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
----------------
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
44.12
40%
-32
- C3 -
-
3N51
3
?
A:
[28-301]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
44.06
40%
-38
- C3 -
-
5T6I
1
?
A:
[69-361]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
------
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK----
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
44.03
40%
-29
- C3 -
-
4IFG
1
?
A:
[51-321]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
43.94
40%
-31
- C3 -
-
5W9E
1
?
A:
[28-299]
---------------------------------------------------------------------------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
-
I
T
G
Q
E
C
A
V
K
V
I
S
K
R
---
Q
-
V
K-
Q
--
K
-
T
D
K
---
E
-
S
L
----
L
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
-
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
--
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
---
L
---
E
S
KSK
D
---
A
N
---
I
R
I
I
D
F
G
L
S
---
T
H
F
-
E
A
-
S
-
K
K
---
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
H
G
-
T
Y
D
------
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
-
G
C
P
P
F
N
--
G
A
N
E
Y
D
I
L
K
K
V
E
K
G
-
K
Y
TF
E
L
--
P
Q
----
W
KK
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
A
R
D
A
L
D
H
----------
E
W
I
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
43.65
35%
-48
- C3 -
-
6GR8
1
AURKC_HUMAN
A:
[9-263]
------------------------------------------------------------------------
V
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
L
K
-
E
S
H
F
I
V
A
L
K
V
L
F
K
S
---
Q
-
I
--
E
--
K
-
E
G
L
---
E
H
Q
L
----
R
R
E
I
E
I
Q
A
H
L
Q
-
H
P
N
I
L
R
L
Y
N
Y
F
-
H
D
A
R
R
V
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
D
--
K
-
L
D
E
Q
R
T
A
T
I
I
E
E
L
A
D
A
L
T
Y
C
H
D
-
K
K
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
F
---
R
---
G
E
---
V
K
I
A
D
F
G
W
S
---
V
H
T
P
S
L
-
R
-
R
K
---
M
---
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
T
Y
D
------
E
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
-
G
Y
P
P
F
E
--
S
A
S
H
S
E
T
Y
R
R
I
L
K
V
-
D
V
--
R
F
--
P
L
----
S
--
M
P
L
G
A
R
D
L
I
S
R
L
L
R
Y
Q
P
L
E
R
L
-----
P
L
A
Q
I
L
K
H
----------
P
W
V
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
43.56
35%
-51
- C3 -
-
6GR9
1
AURKC_HUMAN
A:
[9-263]
------------------------------------------------------------------------
V
D
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
L
K
-
E
S
H
F
I
V
A
L
K
V
L
F
K
S
---
Q
-
I
--
E
--
K
-
E
G
L
---
E
H
Q
L
----
R
R
E
I
E
I
Q
A
H
L
Q
-
H
P
N
I
L
R
L
Y
N
Y
F
-
H
D
A
R
R
V
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
Q
K
S
D
--
K
-
L
D
E
Q
R
T
A
T
I
I
E
E
L
A
D
A
L
T
Y
C
H
D
-
K
K
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
F
---
R
---
G
E
---
V
K
I
A
D
F
G
W
S
---
V
H
T
P
S
L
-
R
-
R
K
---
M
---
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
T
Y
D
------
E
K
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
-
G
Y
P
P
F
E
--
S
A
S
H
S
E
T
Y
R
R
I
L
K
V
-
D
V
--
R
F
--
P
L
----
S
--
M
P
L
G
A
R
D
L
I
S
R
L
L
R
Y
Q
P
L
E
R
L
-----
P
L
A
Q
I
L
K
H
----------
P
W
V
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
43.52
44%
-6
- C3 -
-
6B2E
2
AAPK2_HUMAN
A:
[22-426]
--------------------------------------------------------------------GRVK
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
R-
S
--
L
-
D
V
V
---
G
-
K
I
----
K
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
--
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
E
H
V
P
T
L
F
K
K
I
R
G
G
-
V
F
--
Y
I
--
P
E
----
Y
--
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
Q
G
---------
L
P
S
Y
L
F
P
E
D
P
S
Y
D
A
N
V
I
DDEAVK
E
V
C
E
K
F
E
C
T
E
S
E
V
M
N
S
L
Y
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
43.32
37%
20
- C3 -
-
1QL6
1
PHKG1_RABIT
A:
[18-291]
--------------------------------------------------------------------------
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
-
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
GGG
S
-
F
--
S
--
A
-
E
E
V
---
Q
-
E
L
REAT
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
-
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
--
T
-
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
D
---
M
N
---
I
K
L
T
D
F
G
F
S
---
C
Q
L
-
D
P
-
G
-
E
K
---
L
R
S
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
NHPGY
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
-
G
S
P
P
F
W
--
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
-
N
Y
--
Q
F
GS
P
E
----
W
DD
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
L
A
H
----------
P
F
F
Q
-
Q
Y
----
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
43.10
36%
-9
- C3 -
-
6FCK
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
43.04
37%
25
- C3 -
-
1PHK
1
PHKG1_RABIT
A:
[18-291]
--------------------------------------------------------------------------
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
-
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
GGG
S
-
F
--
S
--
A
-
E
E
V
---
Q
-
E
L
REAT
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
-
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
--
T
-
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
D
---
M
N
---
I
K
L
T
D
F
G
F
S
---
C
Q
L
-
D
P
-
G
-
E
K
---
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
NHPGY
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
-
G
S
P
P
F
W
--
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
-
N
Y
--
Q
F
GS
P
E
----
W
DD
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
L
A
H
----------
P
F
F
Q
-
Q
Y
----
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
43.02
37%
-55
- C3 -
-
4JXF
2
PLK4_HUMAN
A:
[6-257]
------------------------------------------------------------------------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
-
H
T
G
L
E
V
A
I
K
M
I
D
K
K
---
A
-
M
--
Y
--
K
-
A
G
M
V--
Q
-
R
V
----
Q
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
-
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
--
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
---
N
---
M
N
---
I
K
I
A
D
F
G
L
A
---
T
Q
L
-
K
M
P
H
-----------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
-
G
R
P
P
F
------
V
K
N
T
L
N
K
V
V
L
A
-
D
Y
--
E
M
--
P
S
----
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
42.84
39%
-10
- C3 -
-
6T6F
1
?
B:
[16-287]
---------------------------------------------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
-
A
T
G
K
L
F
A
V
K
C
I
P
K
K
---
A
-
L
--
K
GK
E
-
S
S
I
---
E
--------
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
-
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
-
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
E
---
E
---
S
K
---
I
M
I
S
D
F
G
--------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-
G
Y
P
P
F
Y
--
D
E
N
D
S
K
L
F
E
Q
I
L
K
A
-
E
Y
--
E
F
DS
P
Y
----
W
DD
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
A
R
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
42.80
36%
-5
- C3 -
-
2YEX
8
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
42.59
37%
-51
- C3 -
-
3COK
1
PLK4_HUMAN
B:
[1-261]
---------------------------------------------
S
L
----
A
----
T
C
I
G
E
----
K
------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
-
H
T
G
L
E
V
A
I
K
M
I
D
K
K
---
A
-
M
--
Y
--
K
-
A
G
M
V--
Q
-
R
V
----
Q
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
-
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
--
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
---
N
---
M
N
---
I
K
I
A
D
F
G
L
A
---
T
Q
L
-
K
-------------------------------------
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
-
G
R
P
P
F
--------
N
T
L
N
K
V
V
L
A
-
D
Y
--
E
M
--
P
S
----
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
42.57
36%
-9
- C3 -
-
2YDI
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
42.55
45%
-20
- C3 -
-
4RER
2
AAPK1_HUMAN
A:
[5-353]
------------------------------------------------------------------------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
R-
S
--
L
-
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
S
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
42.32
36%
-5
- C3 -
-
2E9V
1
CHK1_HUMAN
B:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
42.27
36%
-9
- C3 -
-
2X8D
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
42.09
36%
-4
- C3 -
-
6FC8
1
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
42.08
45%
2
- C3 -
-
5UFU
2
AAPK1_MOUSE (first)
A:
[11-406]
--------------------------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
--
S
L
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
42.04
45%
-5
- C3 -
-
5KQ5
2
?
A:
[12-423]
--------------------------------------------------------------------RVK-
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
--
S
L
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
42.00
34%
-37
- C3 -
-
5DNR
1
AURKA_HUMAN
A:
[8-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
-----
V
-
H
A
-
P
-
S
S
---
R
R
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
41.98
36%
-42
- C3 -
-
1XH5
3
KAPCA_BOVIN
A:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
41.83
37%
-54
- C3 -
-
4YUR
1
PLK4_HUMAN
A:
[8-263]
----------------------------------------------------------
I
G
E
----
K
------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
-
H
T
G
L
E
V
A
I
K
M
I
D
K
K
---
A
-
M
--
Y
--
K
-
A
G
M
V--
Q
-
R
V
----
Q
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
-
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
--
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
---
N
---
M
N
---
I
K
I
A
D
F
-----------------------------------------------
G
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
-
G
R
P
P
F
-----
T
V
K
N
T
L
N
K
V
V
L
A
-
D
Y
--
E
M
--
P
S
----
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
41.81
32%
-29
- C3 -
-
2VGP
1
AUKBA_XENLA
B:
[2-267]
---------------------------------------------
A
L
----
A
----
E
M
P
K
R
----
K
F
T
----
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
---
Q
-
L
--
E
--
K
-
E
G
V
---
E
H
Q
L
----
R
R
E
I
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
M
Y
N
Y
F
-
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
--
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
W
S
-----
V
-
H
A
-
P
-
S
L
---
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
------
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
D
--
S
P
S
H
T
E
T
H
R
R
I
V
N
V
-
D
L
--
K
F
--
P
P
----
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
V
M
E
H
----------
P
W
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
41.80
33%
-21
- C3 -
-
5VIB
1
KAPCA_BOVIN
A:
[40-351]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
L
K
N
G
V
N
D
IKNHKWFATT
D
W
I
A
I
-
Y
----
Q
R
K
V
E
A
P
F
I
P
K
---------
F
------
D
-----
D
Y
E
E
E
E
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
41.66
45%
1
- C3 -
-
6E4T
2
?
A:
[11-424]
--------------------------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
--
S
L
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
41.57
36%
-37
- C3 -
-
1YDR
1
KAPCA_BOVIN
E:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
41.56
36%
-5
- C3 -
-
2E9V
1
CHK1_HUMAN
A:
[3-265]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
41.55
45%
1
- C3 -
-
4QFS
2
AAPK1_RAT
A:
[11-424]
--------------------------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
--
S
L
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
41.53
36%
-5
- C3 -
-
2YER
7
CHK1_HUMAN
A:
[4-266]
------------------------------------------------------------------
P
F
----
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
-
V
T
E
E
A
V
A
V
K
I
V
D
M
K
---
R
-
A
VD
C
--
P
-
E
N
I
---
K
-
K
-------
E
I
C
I
N
K
M
L
N
-
H
E
N
V
V
K
F
Y
G
H
R
-
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
--
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
-
I
G
I
T
H
R
D
I
K
P
E
N
L
L
---
L
---
D
E
---
R
---
D
N
---
L
K
I
S
D
F
G
L
A
---
T
V
F
-
R
Y
-
N
-
N
R
ERL
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
K
R
R
E
F
H
-----
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
-
G
E
L
P
W
D
QP
S
D
S
C
Q
E
Y
S
D
W
K
E
K
K
-
T
Y
--
L
N
--
P
W
K---
K
--
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
I
P
D
I
K
K
D
----------
R
W
Y
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
41.52
34%
-37
- C3 -
-
5DN3
2
AURKA_HUMAN
A:
[8-265]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
-----
V
-
H
A
-
P
-
S
S
---
R
R
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
41.47
45%
4
- C3 -
-
6E4W
2
?
A:
[11-424]
--------------------------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
--
S
L
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
41.40
34%
-36
- C3 -
-
3E5A
1
AURKA_HUMAN
A:
[4-261]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
-----
V
-
H
A
-
P
-
S
S
---
R
R
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
R
M
H
D
------
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
-
G
K
P
P
F
E
--
A
N
T
Y
Q
E
T
Y
K
R
I
S
R
V
-
E
F
--
T
F
--
P
D
----
F
--
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
L
R
E
V
L
E
H
----------
P
W
I
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
41.34
45%
3
- C3 -
-
4QFR
2
?
A:
[11-424]
--------------------------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
--
S
L
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
41.32
32%
-28
- C3 -
-
2BFY
1
AUKBA_XENLA
B:
[2-267]
---------------------------------------------
A
L
----
A
----
E
M
P
K
R
----
K
F
T
----
I
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
---
Q
-
L
--
E
--
K
-
E
G
V
---
E
H
Q
L
----
R
R
E
I
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
M
Y
N
Y
F
-
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
--
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
W
S
-----
V
-
H
A
-
P
-
S
L
---
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
------
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
D
--
S
P
S
H
T
E
T
H
R
R
I
V
N
V
-
D
L
--
K
F
--
P
P
----
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
V
M
E
H
----------
P
W
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
41.30
34%
24
- C3 -
-
5N23
1
KAPCA_HUMAN
A:
[9-288]
---------------------------
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
LKKW
E
----
S
P
A
Q
N
----
T
A
H
----
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
Q
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
---
V
-
K
-
G
R
---
T
P
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
41.29
36%
-42
- C3 -
-
6E99
1
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
41.19
36%
-38
- C3 -
-
1Q24
1
KAPCA_BOVIN
A:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
41.18
36%
-41
- C3 -
-
1YDS
1
KAPCA_BOVIN
E:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
41.11
37%
-42
- C3 -
-
2GNF
1
KAPCA_BOVIN
A:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
41.10
36%
-1
- C3 -
-
3Q5I
1
?
A:
[38-307]
---------------------------------------------------------------------------
Y
F
K
V
R
K
L
G
S
--
Y
G
E
V
L
L
C
K
E
K
-
N
G
H
S
E
K
A
I
K
V
I
K
K
-----------------KFH
E
-
E
I
----
Y
N
E
I
S
L
L
K
S
L
D
-
H
P
N
I
I
K
L
F
D
V
F
-
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
H
--
K
-
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
-
H
N
I
V
H
R
D
I
K
P
E
N
I
L
---
L
---
E
N
---
K
NSL
L
N
---
I
K
I
V
D
F
G
L
S
---
S
F
F
-
S
K
-
D
-
Y
K
---
L
R
D
R
L
G
T
A
Y
Y
I
A
P
E
V
L
K
-
K
K
Y
N
------
E
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
-
G
Y
P
P
F
G
--
G
Q
N
D
Q
D
I
I
K
K
V
E
K
G
-
K
Y
--
Y
F
--
D
F
NDWK
N
--
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
-----
T
A
E
E
A
L
N
S
----------
R
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
41.09
32%
-27
- C3 -
-
5EYK
1
AUKBA_XENLA
B:
[1-264]
---------------------------------------------------
A
----
E
M
P
K
R
----
K
F
T
----
I
D
D
F
D
I
V
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
---
Q
-
L
--
E
--
K
-
E
G
V
---
E
H
Q
L
----
R
R
E
I
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
M
Y
N
Y
F
-
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
--
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
W
S
-----
V
-
H
A
-
P
-
S
L
---
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
------
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
D
--
S
P
S
H
T
E
T
H
R
R
I
V
N
V
-
D
L
--
K
F
--
P
P
----
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
V
M
E
H
----------
P
W
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
41.01
36%
-39
- C3 -
-
1XH6
1
KAPCA_BOVIN
A:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
40.98
36%
-40
- C3 -
-
2JDV
1
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
40.89
36%
-37
- C3 -
-
6E9L
1
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
40.93
38%
-39
- C3 -
-
2GNL
1
KAPCA_BOVIN
A:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
40.89
38%
25
- C3 -
-
2PHK
2
PHKG1_RABIT
A:
[5-269]
--------------------------------------------------------------------------
N
Y
E
P
K
E
I
L
G
R
G
V
S
S
V
V
R
R
C
I
H
K
-
P
T
C
K
E
Y
A
V
K
I
I
D
V
T
GGG
S
-
F
--
S
--
A
-
E
E
V
---
Q
-
E
L
REAT
L
K
E
V
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
-
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
--
T
-
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
-
L
N
I
V
H
R
D
L
K
P
E
N
I
L
---
L
---
D
D
---
D
---
M
N
---
I
K
L
T
D
F
G
F
S
---
C
Q
L
-
D
P
-
G
-
E
K
---
L
R
E
V
C
G
T
P
S
Y
L
A
P
E
I
I
E
C
S
M
N
D
NHPGY
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
-
G
S
P
P
F
W
--
H
R
K
Q
M
L
M
L
R
M
I
M
S
G
-
N
Y
--
Q
F
GS
P
E
----
W
DD
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
-----
T
A
E
E
A
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
40.86
39%
-13
- C3 -
-
6T6F
1
?
A:
[16-287]
---------------------------------------------------------------------------
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
-
A
T
G
K
L
F
A
V
K
C
I
P
K
K
---
A
-
L
--
K
GK
E
-
S
S
I
---
E
--------
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
-
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
--
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
-
M
G
I
V
H
R
D
L
K
P
E
N
L
L
---
Y
YSQ
D
E
---
E
---
S
K
---
I
M
I
S
D
F
G
L
S
------------------------
P
G
Y
V
A
P
E
V
L
A
Q
K
P
Y
------
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
-
G
Y
P
P
F
Y
--
D
E
N
D
S
K
L
F
E
Q
I
L
K
A
-
E
Y
--
E
F
DS
P
Y
----
W
DD
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
C
E
Q
A
A
R
H
----------
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
40.81
32%
-28
- C3 -
-
2VGO
1
AUKBA_XENLA
A:
[10-267]
-----------------------------------------------------------------
K
F
T
----
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
---
Q
-
L
--
E
--
K
-
E
G
V
---
E
H
Q
L
----
R
R
E
I
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
M
Y
N
Y
F
-
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
--
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
W
S
-----
V
-
H
A
-
P
-
S
L
---
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
------
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
D
--
S
P
S
H
T
E
T
H
R
R
I
V
N
V
-
D
L
--
K
F
--
P
P
----
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
V
M
E
H
----------
P
W
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
40.76
45%
3
- C3 -
-
6E4U
2
AAPK1_RAT
A:
[11-409]
--------------------------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
--
S
L
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
40.75
36%
-36
- C3 -
-
4AXA
1
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
40.74
36%
-40
- C3 -
-
1XH8
1
KAPCA_BOVIN
A:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
40.62
36%
-40
- C3 -
-
4IE9
2
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
40.67
37%
-49
- C3 -
-
3COK
1
PLK4_HUMAN
A:
[1-261]
---------------------------------------------
S
L
----
A
----
T
C
I
G
E
----
K
------
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
-
H
T
G
L
E
V
A
I
K
M
I
D
K
K
---
A
-
M
--
Y
--
K
-
A
G
M
V--
Q
-
R
V
----
Q
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
-
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
--
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
---
L
---
T
R
---
N
---
M
N
---
I
K
I
A
D
F
G
L
A
---
T
Q
L
-
K
--------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
-
G
R
P
P
F
D
--
T
D
T
V
-----
K
V
V
L
A
-
D
Y
--
E
M
--
P
S
----
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
L
S
S
V
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
40.64
36%
-36
- C3 -
-
4IJ9
1
KAPCA_BOVIN
A:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
40.61
32%
-28
- C3 -
-
4B8M
1
AUKBA_XENLA
A:
[11-268]
-----------------------------------------------------------------
K
F
T
----
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
---
Q
-
L
--
E
--
K
-
E
G
V
---
E
H
Q
L
----
R
R
E
I
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
M
Y
N
Y
F
-
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
--
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
W
S
-----
V
-
H
A
-
P
-
S
L
---
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
------
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
D
--
S
P
S
H
T
E
T
H
R
R
I
V
N
V
-
D
L
--
K
F
--
P
P
----
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
V
M
E
H
----------
P
W
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
40.61
32%
-25
- C3 -
-
4B8M
1
AUKBA_XENLA
B:
[3-268]
---------------------------------------------
A
L
----
A
----
E
M
P
K
R
----
K
F
T
----
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
---
Q
-
L
--
E
--
K
-
E
G
V
---
E
H
Q
L
----
R
R
E
I
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
M
Y
N
Y
F
-
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
--
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
W
S
-----
V
-
H
A
-
P
-
S
L
---
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
------
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
D
--
S
P
S
H
T
E
T
H
R
R
I
V
N
V
-
D
L
--
K
F
--
P
P
----
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
V
M
E
H
----------
P
W
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
40.55
45%
2
- C3 -
-
4CFH
1
AAPK1_RAT
A:
[29-358]
--------------------------------------------------------------------RVK-
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
R-
S
--
L
-
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
40.46
36%
-38
- C3 -
-
1YDT
1
KAPCA_BOVIN
E:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
40.43
37%
-35
- C3 -
-
4Z84
1
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
40.38
45%
7
- C3 -
-
5T5T
2
AAPK1_RAT
A:
[11-406]
--------------------------------------------------------------------GRVK
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
-
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
---
K
-
I
--
R
--
S
L
D
V
V
---
G
-
K
I
----
R
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
-
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
--
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
---
L
---
D
A
---
H
---
M
N
---
A
K
I
A
D
F
G
L
S
---
N
M
M
-
S
D
-
G
-
E
F
---
L
R
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
G
R
L
Y
A
-----
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
-
G
T
L
P
F
D
--
D
D
H
V
P
T
L
F
K
K
I
C
D
G
-
I
F
--
Y
T
--
P
Q
----
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
I
K
D
I
R
E
H
----------
E
W
F
K
---------
Q
D
L
P
K
Y
L
F
P
E
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
40.36
36%
-35
- C3 -
-
2UVX
1
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
40.33
36%
-36
- C3 -
-
3ZO4
4
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
40.25
36%
-34
- C3 -
-
2UW7
1
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
40.17
37%
-32
- C3 -
-
4Z83
2
KAPCA_BOVIN
E:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
40.10
36%
-34
- C3 -
-
2JDT
1
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
40.11
38%
-35
- C3 -
-
2GNJ
1
KAPCA_BOVIN
A:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
40.10
32%
-28
- C3 -
-
3ZTX
1
AUKBA_XENLA
A:
[10-267]
-----------------------------------------------------------------
K
F
T
----
I
D
D
F
D
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
---
Q
-
L
--
E
--
K
-
E
G
V
---
E
H
Q
L
----
R
R
E
I
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
M
Y
N
Y
F
-
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
--
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
W
S
-----
V
-
H
A
-
P
-
S
L
---
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
------
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
D
--
S
P
S
H
T
E
T
H
R
R
I
V
N
V
-
D
L
--
K
F
--
P
P
----
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
V
M
E
H
----------
P
W
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
40.05
36%
-38
- C3 -
-
1SVH
1
KAPCA_BOVIN
A:
[39-280]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
40.01
36%
-38
- C3 -
-
2VO7
2
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
39.77
36%
-33
- C3 -
-
2UW4
1
KAPCA_BOVIN
A:
[40-281]
-------------------------------------------------------------------
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
-
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
39.18
32%
-27
- C3 -
-
2VGP
1
AUKBA_XENLA
A:
[11-267]
------------------------------------------------------------------
F
T
----
I
D
D
F
D
I
G
R
P
L
G
K
---
G
N
V
Y
L
A
R
E
K
-
Q
N
K
F
I
M
A
L
K
V
L
F
K
S
---
Q
-
L
--
E
--
K
-
E
G
V
---
E
H
Q
L
----
R
R
E
I
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
M
Y
N
Y
F
-
H
D
R
K
R
I
Y
L
M
L
E
F
A
P
R
G
E
L
Y
K
E
L
Q
K
H
G
--
R
-
F
D
E
Q
R
S
A
T
F
M
E
E
L
A
D
A
L
H
Y
C
H
E
-
R
K
V
I
H
R
D
I
K
P
E
N
L
L
---
M
---
G
Y
---
K
---
G
E
---
L
K
I
A
D
F
G
W
S
-----
V
-
H
A
-
P
-
S
L
---
R
R
R
M
C
G
T
L
D
Y
L
P
P
E
M
I
E
G
K
T
H
D
------
E
K
V
D
L
W
C
A
G
V
L
C
Y
E
F
L
V
-
G
M
P
P
F
D
--
S
P
S
H
T
E
T
H
R
R
I
V
N
V
-
D
L
--
K
F
--
P
P
----
F
--
L
S
D
G
S
K
D
L
I
S
K
L
L
R
Y
H
P
P
Q
R
L
-----
P
L
K
G
V
M
E
H
----------
P
W
V
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
38.38
33%
18
- C3 -
-
5N32
3
KAPCA_CRIGR
A:
[2-283]
-------------------
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
--
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
-
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
38.19
34%
17
- C3 -
-
4UJB
3
KAPCA_HUMAN
A:
[5-281]
-----------------------
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
----
L
KKWE
S
P
A
Q
N
----
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
573
Fugue
37.89
32%
-19
- C3 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
-----------------------------------------------------------
G
W
----
A
L
N
----
M
K
E
L
K
L
L
Q
T
I
G
K
G
E
F
G
D
V
M
L
G
D
Y
R
G---
N
K
V
A
V
K
C
I
-
K
--------------
N
D
A
---
Q
-
A
F
----
L
A
E
A
S
V
M
T
Q
L
R
-
H
S
N
L
V
Q
L
L
G
V
I
V--
E
E
G
L
Y
I
V
T
E
Y
M
A
K
G
S
L
V
D
Y
L
R
S
R
G
RS
V
-
L
G
G
D
C
L
L
K
F
S
L
D
V
C
E
A
M
E
Y
L
E
G
-
N
N
F
V
H
R
D
L
A
A
R
N
V
L
---
V
---
S
E
---
D
---
N
V
---
A
K
V
S
D
F
G
-----------------------
L
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
------
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
--
R
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
--
D
A
--
P
D
----
G
--
C
P
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
-----
S
F
L
Q
L
R
E
Q
----------
L
E
H
I
K
T
H
----
E
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
37.61
34%
23
- C3 -
-
3VQH
2
KAPCA_HUMAN
A:
[5-281]
-----------------------
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
----
L
KKWE
S
P
A
Q
N
----
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
37.27
34%
23
- C3 -
-
5BX6
4
KAPCA_HUMAN
A:
[6-281]
------------------------
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
----
L
KKWE
S
P
A
Q
N
----
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
37.09
34%
20
- C3 -
-
1Q8U
3
KAPCA_BOVIN
A:
[7-280]
--------------------------
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
----
L
----
K
K
W
E
N
PAQN
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
36.70
34%
21
- C3 -
-
1Q8T
1
KAPCA_BOVIN
A:
[10-280]
-----------------------------
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
----
L
----
K
K
W
E
N
PAQN
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
36.35
34%
22
- C3 -
-
5BX7
4
KAPCA_HUMAN
A:
[6-281]
------------------------
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
----
L
KKWE
S
P
A
Q
N
----
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
36.24
34%
17
- C3 -
-
2GNH
2
KAPCA_BOVIN
A:
[10-280]
-----------------------------
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
----
L
----
K
K
W
E
N
PAQN
T
A
H
----
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
36.19
33%
22
- C3 -
-
5N1K
3
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
-----
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
--
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
--
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
36.14
34%
25
- C3 -
-
2GNI
1
KAPCA_BOVIN
A:
[10-280]
-----------------------------
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
----
L
----
K
K
W
E
N
PAQN
T
A
H
----
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
36.01
34%
21
- C3 -
-
1VEB
1
KAPCA_BOVIN
A:
[10-280]
-----------------------------
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
----
L
----
K
K
W
E
N
PAQN
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
35.85
34%
24
- C3 -
-
3L9M
1
KAPCA_HUMAN
A:
[12-281]
-------------------------------
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
----
L
KKWE
S
P
A
Q
N
----
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
35.77
34%
19
- C3 -
-
2VO0
4
KAPCA_BOVIN
A:
[9-281]
---------------------------
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
----
L
----
K
K
W
E
N
PAQN
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
T
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
35.61
34%
26
- C3 -
-
3L9M
1
KAPCA_HUMAN
B:
[14-281]
---------------------------------
E
S
V
K
E
F
L
A
K
A
K
E
D
F
----
L
KKWE
S
P
A
Q
N
----
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
35.41
34%
22
- C3 -
-
3L9N
1
KAPCA_HUMAN
A:
[15-284]
----------------------------------
S
V
K
E
F
L
A
K
A
K
E
D
F
----
L
KKWE
S
P
A
Q
N
----
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
35.36
34%
27
- C3 -
-
4WB6
1
KAPCA_HUMAN
B:
[8-280]
---------------------------
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
LKKW
E
----
S
P
A
Q
N
----
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
35.28
33%
21
- C3 -
-
5M0C
3
KAPCA_CRIGR
A:
[16-283]
--------------------------------
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
34.85
34%
21
- C3 -
-
1STC
1
KAPCA_BOVIN
E:
[15-280]
----------------------------------
V
-
K
E
F
L
A
K
A
K
E
D
F
----
L
----
K
K
W
E
N
PAQN
T
A
H
----
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
34.52
33%
23
- C3 -
-
5M0L
3
KAPCA_CRIGR
A:
[14-283]
------------------------------
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
---
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
31.54
33%
15
- C3 -
-
5N1E
4
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
-------
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
31.35
33%
14
- C3 -
-
5N7U
2
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
31.34
33%
20
- C3 -
-
5LCT
3
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
31.20
33%
16
- C3 -
-
5M75
2
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
31.18
33%
12
- C3 -
-
5N7P
2
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
30.93
33%
16
- C3 -
-
5LCP
4
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
30.90
33%
16
- C3 -
-
5MHI
3
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
------
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
30.82
33%
17
- C3 -
-
5LCU
5
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
30.77
33%
16
- C3 -
-
5LCR
6
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
30.75
35%
18
- C3 -
-
3AMA
1
KAPCA_HUMAN
A:
[2-286]
---------------------
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
LKKW
E
----
S
P
A
Q
N
----
T
A
H
----
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
Q
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
30.73
33%
15
- C3 -
-
5M6V
1
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
30.63
34%
-76
- C3 -
-
2NP8
1
AURKA_HUMAN
A:
[8-166]
-----------------------------------------------------------------
Q
W
A
----
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
-
Q
S
K
F
I
L
A
L
K
V
L
F
K
A
---
Q
-
L
--
E
--
K
-
A
G
V
---
E
H
Q
L
----
R
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
-
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
--
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
---
L
---
G
S
---
A
---
G
E
---
L
K
I
A
D
F
G
W
S
---
V
H
--
A
P
-
S
-
S
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
30.46
35%
22
- C3 -
-
3AMB
1
KAPCA_HUMAN
A:
[4-286]
-----------------------
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
D
F
LKKW
E
----
S
P
A
Q
N
----
T
A
H
----
L
D
Q
F
E
R
I
R
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
Q
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
K
V
A
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
30.38
33%
20
- C3 -
-
5M71
2
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
30.32
33%
16
- C3 -
-
5M0B
4
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
30.24
33%
16
- C3 -
-
5LCQ
3
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
29.78
33%
20
- C3 -
-
5M6Y
2
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
Q
N
----
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
29.63
33%
17
- C3 -
-
5N1D
3
KAPCA_CRIGR
A:
[1-283]
------------------
G
H
M
G
N
A
A
A
A
K
K
G
E
Q
E
S
V
-
K
E
F
L
A
K
A
K
E
E
F
----
L
KKWE
S
P
S
------
T
A
Q
----
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
-
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
---
K
-
V
V-
K
--
L
-
K
Q
I
---
E
-
H
T
----
L
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
-
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
--
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
---
I
---
D
Q
---
Q
---
G
Y
---
I
Q
V
T
D
F
G
F
A
---
K
R
V
-
K
G
-
R
-
T
W
---
L
T
--
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
G
Y
N
-----
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
-
G
Y
P
P
F
F
--
A
D
Q
P
I
Q
I
Y
E
K
I
V
S
G
-
K
V
--
R
F
--
P
S
----
H
--
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------