@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MELK_HUMAN: (2020-09-15 )
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEALKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAVAYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELIQGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLLQQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQTMEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDVTASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKLKNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPIKIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITVLTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQTQSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
Atome Classification :
(374 SA)
.........10........20........30........40...-----.--..-----.--.--50-...-----..---....60........70........80........90........100.-......110.......120.......130.......140-...---.----.---....150...-...-.-160.......170.......180...-......190.......200.......--210.-...-.....220...--.--.-.--.-230.----.--......---.240.......250-----.-----...----...260..-..---...270.......280---...-..----...290....-----...300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
IGTG
G
F
A
K
V
K
L
A
C
H
I
LTG
E
M
V
A
I
K
I
M
DK-----N--TL-----G--S--D--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
TAN
K
I
F
M
V
L
E
YCPG
G
E
L
F
D
Y
I
I
S
Q
D
R-L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
HSQGYAHRDLKPEN
L
L
F
---
D
EY---H----
K
---
L
K
L
I
D
F
GLCA-KPK-G-NKDY
H
L
Q
T
C
C
G
S
L
A
Y
A
A
P
E
L
I--QGK-SYLGSEA
D
V
W
S
M
G
I
L
L
Y
V
L
M
CGFLPF--D--D-D
N
V
-
M
A
L
Y
K
K
I
MRGK--Y--D-V--P-K--W----L--S
P
S
S
I
L
---
L
L
Q
Q
M
L
QVD
P
K
K
R
I
-----
S
-----
M
K
N
----LLNHP
W
I
M-QD---YNYP
V
E
WQSKNP
F
I
H
----LDD-
D
C
----
V
T
E
L
S
V
HHRN-----N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
KARGK
P
V
R
L
R
L
SSFSCGQASATPFTDIKSNNWSLEDVTASDKN
Y
V
A
G
LIDYDWCE
D
D
L
STGAATPRT
S
Q
F
T
K
YWTESNGVESKSL
T
P
A
L
C
RT
P
A
N
KLKNKENVYTPKSAVKNE
E
Y
F
MFPEPKTPVNK
N
Q
H
K
R
E
ILTTPNRYTT
P
S
K
A
R
N
Q
C
L
KETP
I
K
I
PVNSTG
T
D
K
L
M
T
G
VI
S
P
E
R
RC
R
S
V
E
LDL
N
Q
A
H
M
E
ETPKR
K
G
A
K
V
F
G
S
L
E
R
G
L
D
K
V
I
T
V
L
T
RSKRKGSARDG
P
R
R
L
K
L
H
Y
NV
T
T
T
RLV
N
P
D
Q
L
L
N
E
I
M
S
IL
P
K
K
H
V
D
F
V
QKG
Y
T
L
K
C
Q
TQSDF
G
K
V
T
M
Q
F
E
L
E
V
C
QLQKPD
V
V
G
I
R
R
Q
RLKG
D
A
W
V
Y
K
R
L
V
E
D
I
L
S
SCKV
30
Blastp_CBE
91.62
98%
-140
- C3 -
-
4D2W
2
MELK_HUMAN
B:
[21-353]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
K
-
G
-
N
K
D
------
C
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
91.38
98%
-136
- C3 -
-
4UMP
1
MELK_HUMAN
B:
[21-353]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
K
-
G
-
N
K
D
------
C
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
91.23
98%
-133
- C3 -
-
4D2P
2
MELK_HUMAN
B:
[21-353]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
K
-
G
-
N
K
D
------
C
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
91.06
98%
-138
- C3 -
-
4D2T
2
MELK_HUMAN
B:
[21-353]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
K
-
G
-
N
K
D
------
C
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
90.76
98%
-140
- C3 -
-
4D2W
2
MELK_HUMAN
D:
[21-353]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
K
-
G
-
N
K
-------
C
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
90.64
98%
-138
- C3 -
-
4D2V
2
MELK_HUMAN
B:
[22-353]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
K
-
G
-
N
K
D
------
C
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
HHSearch
90.41
100%
-144
- C3 -
-
5TVT
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
---------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
90.41
100%
-144
- C3 -
-
5TVT
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
---------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
90.35
98%
-145
- C3 -
-
4D2V
2
MELK_HUMAN
D:
[23-353]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
K
-
G
-
N
K
--------
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
--
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
---
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
89.95
98%
-154
- C3 -
-
4UMT
2
MELK_HUMAN
A:
[23-353]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
89.93
98%
-152
- C3 -
-
4UMU
1
MELK_HUMAN
A:
[23-353]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
89.78
100%
-142
- C3 -
-
5TWL
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
89.38
98%
-148
- C3 -
-
4D2V
2
MELK_HUMAN
A:
[21-353]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
------------
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------
C
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
89.24
98%
-148
- C3 -
-
4D2W
1
MELK_HUMAN
A:
[21-353]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
------------
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
----------------
C
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
89.07
98%
-140
- C3 -
-
4D2T
2
MELK_HUMAN
D:
[23-353]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
K
-
G
-
N
K
--------
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
---------
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
89.06
98%
-148
- C3 -
-
4D2T
1
MELK_HUMAN
A:
[21-353]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
------------
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
---------------
A
C
C
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
--
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
89.06
98%
-130
- C3 -
-
4UMP
1
MELK_HUMAN
D:
[22-353]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
K
-
G
-
N
K
D
-------
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
----
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
88.92
98%
-136
- C3 -
-
4D2P
2
MELK_HUMAN
C:
[21-353]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
------------
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
---------------
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
--
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
88.83
98%
-140
- C3 -
-
4D2V
2
MELK_HUMAN
C:
[21-353]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
------------------
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
---------------
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
88.81
98%
-141
- C3 -
-
4D2W
1
MELK_HUMAN
C:
[21-353]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
------------------
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
---------------
G
A
L
A
Y
A
A
P
E
L
I
--
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.67
100%
-147
- C3 -
-
5TWY
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
------------
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
88.59
99%
-146
- C3 -
-
5M5A
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
---
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
88.52
98%
-161
- C3 -
-
4UMR
1
MELK_HUMAN
A:
[26-353]
-----
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
88.34
99%
-147
- C3 -
-
4BKY
1
MELK_HUMAN
A:
[4-334]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----------
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
88.02
99%
-143
- C3 -
-
5MAH
2
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
----------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
---
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
87.96
100%
-134
- C3 -
-
6GVX
3
MELK_HUMAN
B:
[5-339]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
---------
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
--------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
87.79
98%
-151
- C3 -
-
4UMQ
1
MELK_HUMAN
A:
[25-353]
----
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
T
A
-
A
A
L
V
A
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.72
99%
-148
- C3 -
-
4BKZ
1
MELK_HUMAN
A:
[3-335]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
--------------
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
HHSearch
87.50
100%
-141
- C3 -
-
5K00
1
MELK_HUMAN
A:
[2-326]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
---------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.46
99%
-143
- C3 -
-
5MAG
3
MELK_HUMAN
A:
[4-336]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
-
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----------
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
----------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
---
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
87.45
99%
-147
- C3 -
-
5MAI
2
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
----------------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
--
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
87.30
99%
-141
- C3 -
-
5K00
1
MELK_HUMAN
A:
[2-326]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
--
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
---------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
87.15
100%
-148
- C3 -
-
5TWZ
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
--------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.99
100%
-133
- C3 -
-
6GVX
3
MELK_HUMAN
A:
[5-337]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
--
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
------------
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
P
K
-
G
-
N
K
-------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
------------
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
86.92
99%
-142
- C3 -
-
5IH9
1
MELK_HUMAN
A:
[2-326]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
---------------
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
----------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.91
99%
-141
- C3 -
-
4BL1
1
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
--------------
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
----------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
86.63
99%
-139
- C3 -
-
5MAF
2
MELK_HUMAN
A:
[3-334]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----------
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
----------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
---
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
85.76
99%
-146
- C3 -
-
5IH8
1
MELK_HUMAN
A:
[2-326]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
------------
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
----------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
85.76
99%
-150
- C3 -
-
5IHA
1
MELK_HUMAN
A:
[2-326]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
----
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
----------------
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
----------------
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
85.54
99%
-152
- C3 -
-
5IHC
1
MELK_HUMAN
A:
[2-326]
--
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
T
L
-----
G
--
S
--
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
---------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
-
S
Y
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.60
100%
-150
- C3 -
-
5TX3
2
MELK_HUMAN
A:
[5-337]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--------------------------
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
-------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
84.54
100%
-145
- C3 -
-
5TWY
1
MELK_HUMAN
B:
[3-333]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
T
---
A
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
---------------
D
--
L
P
R
-----
I
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
F
G
L
C
--------------------
L
A
Y
A
A
P
E
L
I
--
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
83.52
100%
-149
- C3 -
-
5TX3
2
MELK_HUMAN
B:
[5-338]
M
K
D
Y
D
E
L
L
K
Y
Y
E
L
H
E
T
I
G
-----
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
K
---------------------------------
K
---
T
E
I
E
A
L
K
N
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
Y
---
H
----
K
---
L
K
L
I
D
----------------------
G
S
L
A
Y
A
A
P
E
L
I
--
Q
G
----
L
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
D
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
K
N
----
L
L
N
H
P
W
I
M
-
Q
D
---
Y
N
Y
P
V
E
W
Q
S
K
N
P
F
I
H
----
L
D
D
-
D
C
----
V
T
E
L
S
V
H
H
R
N
-----
N
R
Q
T
M
E
D
L
I
S
L
W
Q
Y
D
H
L
T
A
T
Y
L
L
L
L
A
K
K
A
R
G
K
P
V
R
L
R
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
82.11
93%
-142
- C3 -
-
4CQG
1
MELK_MOUSE
A:
[2-312]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
A
L
-----
G
--
S
--
D
--
L
P
R
-----
V
K
---
T
E
I
D
A
L
K
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
N
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
--------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
E
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
R
N
----
L
L
N
H
P
W
V
M
-
Q
D
---
Y
S
C
P
V
E
W
Q
S
K
T
P
L
T
H
----
L
D
E
-
D
C
----
V
T
E
L
S
V
H
H
R
S
-----
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
81.50
93%
-144
- C3 -
-
4BFM
1
MELK_MOUSE
A:
[2-312]
-
K
D
Y
D
E
L
L
K
Y
Y
E
L
Y
E
T
I
G
T
G
G
F
A
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
K
-----
N
--
A
L
-----
G
--
S
--
D
--
L
P
R
-----
V
K
---
T
E
I
D
A
L
K
S
L
R
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
Y
I
I
S
Q
D
R
-
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
N
---
H
----
K
---
L
K
L
I
D
F
G
L
C
A
-
K
--------------
C
G
S
L
A
Y
A
A
P
E
L
I
--
Q
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
--
D
-
D
N
V
-
M
A
L
Y
K
K
I
M
R
G
K
--
Y
--
E
-
V
--
P
-
K
--
W
----
L
--
S
P
S
S
I
L
---
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
-----
S
-----
M
R
N
----
L
L
N
H
P
W
V
M
-
Q
D
---
Y
S
C
P
V
E
W
Q
S
K
T
P
L
T
H
----
L
D
E
-
D
C
----
V
T
E
L
S
V
H
H
R
S
-----
S
R
Q
T
M
E
D
L
I
S
S
W
Q
Y
D
H
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
59.12
44%
-65
- C3 -
-
5KZ8
1
MARK2_HUMAN
A:
[35-343]
----------
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--
Q
L
N----
S
--
S
--
S
--
L
Q
K
-----
L
F
---
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
-------------------
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
-
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--
D
--
G
-
Q
N
L
-
K
E
L
R
E
R
V
L
R
G
K
--
Y
--
R
-
I
--
P
-
F
--
Y
----
M
--
S
T
D
C
E
N
---
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
-----
L
E
Q
----
I
M
K
D
R
W
M
--------
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
PLPD
Y
K
D
-
P
R
----
R
T
E
L
M
V
S
M
G
Y
-----
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
58.71
43%
-68
- C3 -
-
5ES1
1
MARK4_HUMAN
A:
[17-325]
----------
Y
R
L
L
R
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
-----
T
--
Q
L
-----
N
P-
S
--
S
--
L
Q
K
-----
L
F
---
R
E
V
R
I
M
K
G
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
Y
L
V
S
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
E
---
A
----
N
---
I
K
I
A
D
F
G
F
S
N
------------------
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
-
K
Y
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--
D
--
G
-
H
N
L
-
K
E
L
R
E
R
V
L
R
G
K
--
Y
--
R
-
V
--
P
-
F
--
Y
----
M
--
S
T
D
C
E
S
---
I
L
R
R
F
L
V
L
N
P
A
K
R
C
-----
T
-----
L
E
Q
----
I
M
K
D
K
W
I
--------
N
I
G
Y
E
G
E
E
L
K
P
Y
T
E
----
P
E
E
-
D
F
GDTK
R
I
E
V
M
V
G
M
G
Y
-----
T
R
E
E
I
K
E
S
L
T
S
Q
K
Y
N
E
V
T
A
T
Y
L
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
58.60
44%
-66
- C3 -
-
5EAK
1
MARK2_HUMAN
A:
[17-325]
----------
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--
Q
L
N----
S
--
S
--
S
--
L
Q
K
-----
L
F
---
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
F
S
----------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
-
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--
D
--
G
-
Q
N
L
-
K
E
L
R
E
R
V
L
R
G
K
--
Y
--
R
-
I
--
P
-
F
--
Y
----
M
--
S
T
D
C
E
N
---
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
-----
L
E
Q
----
I
M
K
D
R
W
M
--------
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
PLPD
Y
K
D
-
P
R
----
R
T
E
L
M
V
S
M
G
Y
-----
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
58.54
44%
-64
- C3 -
-
5EAK
1
MARK2_HUMAN
B:
[17-325]
----------
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--
Q
L
N----
S
--
S
--
S
--
L
Q
K
-----
L
F
---
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
G
------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
-
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--
D
--
G
-
Q
N
L
-
K
E
L
R
E
R
V
L
R
G
K
--
Y
--
R
-
I
--
P
-
F
--
Y
----
M
--
S
T
D
C
E
N
---
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
-----
L
E
Q
----
I
M
K
D
R
W
M
--------
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
PLPD
Y
K
D
-
P
R
----
R
T
E
L
M
V
S
M
G
Y
-----
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
57.39
44%
-60
- C3 -
-
5KZ8
1
MARK2_HUMAN
B:
[35-343]
----------
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--
Q
L
N----
S
--
S
--
S
--
L
Q
K
-----
L
F
---
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
---------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
-
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--
D
--
G
-
Q
N
L
-
K
E
L
R
E
R
V
L
R
G
K
--
Y
--
R
-
I
--
P
-
F
--
Y
----
M
--
S
T
D
C
E
N
---
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
-----
L
E
Q
----
I
M
K
D
R
W
M
--------
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
PLPD
Y
K
D
-
P
R
----
R
T
E
L
M
V
S
M
G
Y
-----
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
56.85
37%
-103
- C3 -
-
6T6F
1
?
A:
[7-290]
-
K
Q
A
E
D
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
-----
K
--
A
L
-----
K
--
G
--
K
--
E
S
S
-----
I
E
---
N
E
I
A
V
L
R
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSQ
D
E
E
---
S
----
K
---
I
M
I
S
D
F
G
L
-
S
-------------------
P
G
Y
V
A
P
E
V
L
--
A
Q
K
-
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
-
E
N
D
-
S
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
-
S
--
P
-
Y
--
W
DD--
I
--
S
D
S
A
K
D
---
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
-----
C
E
Q
----
A
A
R
H
P
W
I
A
-
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
56.74
37%
-102
- C3 -
-
6T6F
1
?
B:
[7-290]
-
K
Q
A
E
D
I
K
K
I
F
E
F
K
E
T
L
G
T
G
A
F
S
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
P
K
-----
K
--
A
L
-----
K
--
G
--
K
--
E
S
S
-----
I
E
---
N
E
I
A
V
L
R
K
I
K
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSQ
D
E
E
---
S
----
K
---
I
M
I
S
D
F
G
----------------------
P
G
Y
V
A
P
E
V
L
--
A
Q
K
-
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
-
E
N
D
-
S
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
-
S
--
P
-
Y
--
W
DD--
I
--
S
D
S
A
K
D
---
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
-----
T
-----
C
E
Q
----
A
A
R
H
P
W
I
A
-
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
56.56
44%
-63
- C3 -
-
5KZ7
1
MARK2_HUMAN
A:
[35-343]
----------
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--
Q
L
N----
S
--
S
--
S
--
L
Q
K
-----
L
F
---
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
---------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
---
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--
D
-----
N
L
-
K
E
L
R
E
R
V
L
R
G
K
--
Y
--
R
-
I
--
P
-
F
--
Y
----
M
--
S
T
D
C
E
N
---
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
-----
L
E
Q
----
I
M
K
D
R
W
M
--------
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
PLPD
Y
K
D
-
P
R
----
R
T
E
L
M
V
S
M
G
Y
-----
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
56.03
44%
-60
- C3 -
-
5KZ7
1
MARK2_HUMAN
B:
[35-343]
----------
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
K
-----
T
--
Q
L
N----
S
--
S
--
S
--
L
Q
K
-----
L
F
---
R
E
V
R
I
M
K
V
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
H
G
R
-
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
D
---
M
----
N
---
I
K
I
A
D
F
---------------------
G
S
P
P
Y
A
A
P
E
L
F
--
Q
G
K
---
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--
D
-----
N
L
-
K
E
L
R
E
R
V
L
R
G
K
--
Y
--
R
-
I
--
P
-
F
--
Y
----
M
--
S
T
D
C
E
N
---
L
L
K
K
F
L
I
L
N
P
S
K
R
G
-----
T
-----
L
E
Q
----
I
M
K
D
R
W
M
--------
N
V
G
H
E
D
D
E
L
K
P
Y
V
E
PLPD
Y
K
D
-
P
R
----
R
T
E
L
M
V
S
M
G
Y
-----
T
R
E
E
I
Q
D
S
L
V
G
Q
R
Y
N
E
V
M
A
T
Y
L
L
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
56.00
36%
-77
- C3 -
-
4IEB
1
?
A:
[51-309]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--
Q
V
--------
T
--
D
--
K
E
S
-----
L
L
---
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
DAN
I
R
I
I
D
F
G
L
S
T
-
H
F
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
--
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
----
P
-
Q
--
W
KK--
V
--
S
E
S
A
K
D
---
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
----
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
55.00
36%
-103
- C3 -
-
5JZJ
1
B:
[38-295]
----------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
-----
S
--
K
C
-----
R
--
G
--
K
--
E
H
M
-----
I
Q
---
N
E
V
S
I
L
R
R
V
K
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
N
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
---
Y
E
H
---
Q
DGSK
S
---
L
K
L
G
D
F
G
L
A
T
-
I
V
D
-
G
-
P
----
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
--
A
E
T
-
G
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R----------
E
V
L
F
D
Q
I
L
M
G
Q
--
V
--
D
-
F
--
P
-
S
PY
W
DN--
V
--
S
D
S
A
K
E
---
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
-----
A
V
Q
----
V
L
E
H
P
W
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
54.76
35%
-94
- C3 -
-
4FG7
1
KCC1A_HUMAN
A:
[11-277]
-
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
---------------------------
S
-----
M
E
---
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
----
K
---
I
M
I
S
D
F
G
L
S
K
-
M
E
D
-
P
-----------
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
----
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
-
E
N
D
-
A
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
-
S
--
P
-
Y
--
W
DD--
I
--
S
D
S
A
K
D
---
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
-----
C
E
Q
----
A
L
Q
H
P
W
I
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
54.37
36%
-92
- C3 -
-
5JZN
1
B:
[21-278]
----------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
-----
S
--
K
C
-----
R
--
G
--
K
--
E
H
M
-----
I
Q
---
N
E
V
S
I
L
R
R
V
K
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
N
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
---
Y
E
H
---
Q
DGSK
S
---
L
K
L
G
D
F
G
L
A
T
-
I
V
D
-
G
-
P
----
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
--
A
E
T
-
G
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
RG
S
------
Q
-
E
V
L
F
D
Q
I
L
M
G
Q
--
V
--
D
-
F
--
P
-
S
PY
W
DN--
V
--
S
D
S
A
K
E
---
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
-----
A
V
Q
----
V
L
E
H
P
W
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
54.20
47%
-15
- C3 -
-
6C9H
2
AAPK1_HUMAN
A:
[13-346]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
M
S
-
D
-
G
E
--
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
------
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
53.68
36%
-76
- C3 -
-
3HX4
3
?
A:
[52-309]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
---------------------
D
--
K
E
S
-----
L
L
---
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
DAN
I
R
I
I
D
F
G
L
S
T
-
H
F
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
--
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
-
L
--
P
-
Q
--
W
KK--
V
--
S
E
S
A
K
D
---
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
----
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
53.33
34%
-37
- C3 -
-
6BAB
2
KCC2D_MOUSE
B:
[15-275]
----------
Y
Q
L
F
E
E
L
G
----
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--
K
L
-----
S
--
A
R-
D
--
H
Q
K
-----
L
E
---
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
-
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
-
F
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
D
---
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
S
E
----
A
L
K
H
P
W
I
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
53.24
35%
-47
- C3 -
-
5HU3
1
KCC2A_DROME
A:
[16-274]
----------
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
T
-----
K
--
K
L
-----
T
--
A
R-
D
--
F
Q
K
-----
L
E
---
R
E
A
R
I
C
R
K
L
H
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
L
L
---
A
S
K
---
A
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
H
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
K
E
-
P
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
R
L
Y
S
Q
I
K
A
G
A
--
Y
--
D
-
Y
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
N
---
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
-----
A
A
E
----
A
L
K
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
53.20
36%
-82
- C3 -
-
5JZN
1
DCLK1_HUMAN
A:
[21-278]
----------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
-----
S
--
K
C
-----
R
--
G
--
K
--
E
H
M
-----
I
Q
---
N
E
V
S
I
L
R
R
V
K
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
N
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
---
Y
E
H
---
Q
DGSK
S
---
L
K
L
G
D
F
G
L
A
T
-
I
V
D
-
G
-
P
----
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
--
A
E
T
-
G
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
RG
S
-----
D
Q
-
E
V
L
F
D
Q
I
L
M
G
Q
--
V
--
D
-
F
--
P
-
S
PY
W
DN--
V
--
S
D
S
A
K
E
---
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
-----
A
V
Q
----
V
L
E
H
P
W
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
53.17
34%
-37
- C3 -
-
6AYW
2
KCC2D_HUMAN
B:
[15-275]
----------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--
K
L
-----
S
--
A
R-
D
--
H
Q
K
-----
L
E
---
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
-
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
-
F
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
D
---
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
S
E
----
A
L
K
H
P
W
I
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
53.16
35%
-39
- C3 -
-
5FG8
3
KCC2A_DROME
A:
[16-276]
----------
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
T
-----
K
--
K
L
-----
T
--
A
R-
D
--
F
Q
K
-----
L
E
---
R
E
A
R
I
C
R
K
L
H
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
A
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
H
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
K
E
-
P
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
R
L
Y
S
Q
I
K
A
G
A
--
Y
--
D
-
Y
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
N
---
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
-----
A
A
E
----
A
L
K
H
P
W
I
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
53.03
34%
-77
- C3 -
-
2X8D
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
52.97
34%
-39
- C3 -
-
6BAB
1
KCC2D_MOUSE
D:
[15-275]
----------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--
K
L
-----
S
--
A
R-
D
--
H
Q
K
-----
L
E
---
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
-
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
-
F
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
D
---
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
S
E
----
A
L
K
H
P
W
I
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
52.98
35%
-99
- C3 -
-
2W4O
1
KCC4_HUMAN
A:
[49-320]
----
D
A
L
S
D
F
F
E
V
E
S
E
L
G
R
G
A
T
S
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
K
---------------------------------------
I
G
V
L
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
G
Y
-
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
---
A
T
P
APD
A
----
P
---
L
K
I
A
D
F
---------------------
G
T
P
G
Y
C
A
P
E
I
L
--
R
G
C
-
A
Y
-
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y-
D
--
E
-
R
G
D
-
Q
F
M
F
R
R
I
L
N
C
E
--
Y
--
Y
-
F
IS
P
-
W
--
W
DE--
V
--
S
L
N
A
K
D
---
L
V
R
K
L
I
V
L
D
P
K
K
R
L
-----
T
-----
T
F
Q
----
A
L
Q
H
P
W
V
T
-
G
-----------
K
A
A
N
-
F
V
H
----
M
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
52.97
36%
-88
- C3 -
-
5JZJ
2
DCLK1_HUMAN
A:
[38-295]
----------
Y
K
V
G
R
T
I
G
D
G
N
F
A
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
K
K
-----
S
--
K
C
-----
R
--
G
--
K
--
E
H
M
-----
I
Q
---
N
E
V
S
I
L
R
R
V
K
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
T
N
K
-
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
L
V
---
Y
E
H
---
Q
DGSK
S
---
L
K
L
G
D
F
G
L
A
T
-
I
V
D
-
G
-
P
----
L
Y
T
V
C
G
T
P
T
Y
V
A
P
E
I
I
--
A
E
T
-
G
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
RG
S
--------
E
V
L
F
D
Q
I
L
M
G
Q
--
V
--
D
-
F
--
P
-
S
PY
W
DN--
V
--
S
D
S
A
K
E
---
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
-----
S
-----
A
V
Q
----
V
L
E
H
P
W
V
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
52.94
34%
-37
- C3 -
-
5VLO
2
KCC2D_HUMAN
B:
[15-275]
----------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--
K
L
-----
S
--
A
R-
D
--
H
Q
K
-----
L
E
---
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
-
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
-
F
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
D
---
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
S
E
----
A
L
K
H
P
W
I
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
568
HHSearch
52.87
49%
-13
- C3 -
-
6C9H
2
AAPK1_HUMAN
A:
[11-321]
-----
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
SL
D
--
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
M
S
-
D
-
G
E
--
F
L
R
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
52.80
35%
-44
- C3 -
-
3BHH
1
KCC2B_HUMAN
B:
[6-266]
----------
Y
Q
L
Y
E
D
I
G
K
---
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
-----
K
--
K
L
-----
S
--
A
R-
D
--
H
Q
K
-----
L
E
---
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
C
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
Q
Q
A
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
E
-
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
K
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
-
F
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
N
---
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
H
E
----
A
L
K
H
P
W
V
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
52.60
35%
-46
- C3 -
-
3BHH
1
KCC2B_HUMAN
A:
[6-266]
----------
Y
Q
L
Y
E
D
I
G
----
S
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
T
-----
K
--
K
L
-----
S
--
A
R-
D
--
H
Q
K
-----
L
E
---
R
E
A
R
I
C
R
L
L
K
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
C
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
Q
Q
A
W
F
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
E
-
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
K
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
-
F
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
N
---
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
H
E
----
A
L
K
H
P
W
V
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
52.56
39%
-76
- C3 -
-
3F3Z
5
?
A:
[9-265]
--------
Q
Y
Y
T
L
E
N
T
I
G
R
G
S
W
G
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
K
-----
Y
--
F
V
--------
E
--
D
--
V
D
R
-----
F
K
---
Q
E
I
E
I
M
K
S
L
D
H
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
R
V
V
H
K
R
V
-
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
L
F
LTD
S
P
D
---
S
----
P
---
L
K
L
I
D
F
G
L
A
A
-
R
F
K
-
P
-
G
K
--
M
M
R
T
K
V
G
T
P
Y
Y
V
S
P
Q
V
L
--
E
G
---
L
Y
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
--
S
AP
T
-
D
E
V
-
M
L
---
K
I
R
E
G
T
--
F
--
T
-
F
--
P
-
E
KD
W
----
L
NV
S
P
Q
A
E
S
---
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
-----
T
-----
S
L
Q
----
A
L
E
H
E
W
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
52.45
35%
-93
- C3 -
-
4FG8
1
KCC1A_HUMAN
B:
[14-279]
----
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-------------------------------------
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
----
K
---
I
M
I
S
D
F
G
------------
G
S
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
-
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
-
E
N
D
-
A
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
-
S
--
P
-
Y
--
W
DD--
I
--
S
D
S
A
K
D
---
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
-----
C
E
Q
----
A
L
Q
H
P
W
I
A
-
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
52.41
34%
-39
- C3 -
-
6AYW
2
KCC2D_HUMAN
A:
[15-275]
----------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--
K
L
-----
S
--
A
R-
D
--
H
Q
K
-----
L
E
---
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
-
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
-
F
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
D
---
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
S
E
----
A
L
K
H
P
W
I
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
52.39
35%
-36
- C3 -
-
5H9B
2
KCC2A_DROME
A:
[16-276]
----------
Y
D
I
K
E
E
L
G
K
G
A
F
S
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
T
-----
K
--
K
L
-----
T
--
A
R-
D
--
F
Q
K
-----
L
E
---
R
E
A
R
I
C
R
K
L
H
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
F
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
A
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
H
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
K
K
E
-
P
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
R
L
Y
S
Q
I
K
A
G
A
--
Y
--
D
-
Y
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
N
---
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
-----
T
-----
A
A
E
----
A
L
K
H
P
W
I
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
52.37
34%
-42
- C3 -
-
5VLO
2
KCC2D_HUMAN
A:
[15-275]
----------
Y
Q
L
F
E
E
L
G
---
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--
K
L
-----
S
--
A
R-
D
--
H
Q
K
-----
L
E
---
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
-
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
-
F
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
D
---
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
S
E
----
A
L
K
H
P
W
I
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
52.35
34%
-78
- C3 -
-
4FTI
3
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
52.33
34%
-80
- C3 -
-
4FTU
4
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
52.19
34%
-77
- C3 -
-
4FT7
4
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
52.17
34%
-75
- C3 -
-
3TKI
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
52.17
36%
-70
- C3 -
-
3LIJ
1
?
A:
[35-301]
------
L
S
E
M
Y
Q
R
V
K
K
L
G
S
---
G
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
K
------------------
S
--
S
--
N
S
K
-----
L
L
---
E
E
V
A
V
L
K
L
L
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
-
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
E
----
K
DAL
I
K
I
V
D
F
G
L
S
A
-
V
F
E
-
N
-
Q
K
--
K
M
K
E
R
L
G
T
A
Y
Y
I
A
P
E
V
L
--
R
K
K
---
Y
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
--
G
--
G
-
Q
T
D
-
Q
E
I
L
R
K
V
E
K
G
K
--
Y
TF
D
-
S
--
P
-
E
--
W
KN--
V
--
S
E
G
A
K
D
---
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
-----
S
-----
A
Q
Q
----
A
L
E
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
52.17
34%
-77
- C3 -
-
4FSN
2
CHK1_HUMAN
A:
[7-276]
----------
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
52.06
34%
-79
- C3 -
-
4FT9
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
52.05
34%
-38
- C3 -
-
6BAB
2
KCC2D_MOUSE
A:
[15-275]
----------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
T
-----
K
--
K
L
-----
S
--
A
R-
D
--
H
Q
K
-----
L
E
---
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
-
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
-
F
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
D
---
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
S
E
----
A
L
K
H
P
W
I
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
52.04
34%
-83
- C3 -
-
4QYH
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
52.02
34%
-79
- C3 -
-
4QYG
1
CHK1_HUMAN
B:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
52.01
34%
-77
- C3 -
-
4FSR
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
52.00
34%
-77
- C3 -
-
2YDI
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
51.90
35%
-80
- C3 -
-
2E9N
1
CHK1_HUMAN
A:
[8-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
51.92
34%
-82
- C3 -
-
1ZYS
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
A
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
51.90
47%
-45
- C3 -
-
6BX6
1
AAPK2_HUMAN
A:
[10-274]
-------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
K
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
---------------------
N
Y
A
A
P
E
---------
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
E
H
V
-
P
T
L
F
K
K
I
R
G
G
V
--
F
--
Y
-
I
--
P
-
E
--
Y
----
L
--
N
R
S
V
A
T
---
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPS
Y
L
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
51.84
33%
-63
- C3 -
-
5VJA
2
DAPK3_HUMAN
B:
[6-269]
---------
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--
R
------
G
--
V
--
S
--
R
E
E
-----
I
E
---
R
E
V
N
I
L
R
E
I
R
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
E
T
K
-
Q
E
T
L
T
N
I
S
A
V
N
--
Y
--
D
-
F
D-
E
-
E
--
Y
----
F
--
S
N
T
S
E
L
AKD
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
-----
I
A
Q
----
S
L
E
H
S
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
51.84
35%
-79
- C3 -
-
6FCK
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
51.75
34%
-77
- C3 -
-
4QYE
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
51.66
34%
-81
- C3 -
-
3TKH
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
51.66
35%
-83
- C3 -
-
6FC8
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
51.66
34%
-74
- C3 -
-
4QYF
1
CHK1_HUMAN
A:
[9-280]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
51.60
35%
-100
- C3 -
-
4FG9
1
KCC1A_HUMAN
B:
[14-279]
----
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
--------------------------------------
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
----
K
---
I
M
I
S
D
F
---------------
V
L
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
-
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
-
E
N
D
-
A
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
-
S
--
P
-
Y
--
W
DD--
I
--
S
D
S
A
K
D
---
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
-----
C
E
Q
----
A
L
Q
H
P
W
I
A
-
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
51.56
34%
-77
- C3 -
-
2QHM
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
51.51
34%
-81
- C3 -
-
4FT5
2
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
51.47
34%
-79
- C3 -
-
4QYG
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
51.46
34%
-79
- C3 -
-
4RVK
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
51.46
34%
-81
- C3 -
-
4RVM
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
51.46
35%
-100
- C3 -
-
4FG9
1
KCC1A_HUMAN
A:
[11-279]
-
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
-----
E
---------------------------
E
---
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
----
K
---
I
M
I
S
D
F
-----------------------
P
G
Y
V
A
P
E
V
L
--
A
Q
K
-
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
-
E
N
D
-
A
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
-
S
--
P
-
Y
--
W
DD--
I
--
S
D
S
A
K
D
---
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
-----
C
E
Q
----
A
L
Q
H
P
W
I
A
-
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
51.39
34%
-71
- C3 -
-
2HY0
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
51.39
34%
-83
- C3 -
-
2BRG
1
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
-------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
51.38
34%
-76
- C3 -
-
2BR1
1
CHK1_HUMAN
A:
[9-276]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
51.36
34%
-76
- C3 -
-
2HOG
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
51.32
34%
-81
- C3 -
-
4FT0
2
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
----
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
51.30
34%
-79
- C3 -
-
4FTJ
3
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
51.29
47%
-33
- C3 -
-
3AQV
1
AAPK2_HUMAN
A:
[10-275]
-------
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
K
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
G
R
-
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
M
S
-
D
-
G
E
--
F
L
------
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
E
H
V
-
P
T
L
F
K
K
I
R
G
G
V
--
F
--
Y
-
I
--
P
-
E
--
Y
----
L
--
N
R
S
V
A
T
---
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPS
Y
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
51.28
34%
-77
- C3 -
-
1NVS
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
51.21
34%
-78
- C3 -
-
4QYH
1
CHK1_HUMAN
B:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
51.21
34%
-78
- C3 -
-
4FSQ
1
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
51.20
38%
-99
- C3 -
-
5XZV
1
?
B:
[200-467]
------------
I
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
S
K
-----
R
--
K
---------------
M
D
G
-----
V
T
---
R
E
L
E
V
L
Q
K
L
N
H
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
-
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
EQ-
D
D
P
---
V
----
L
---
V
K
I
T
D
F
G
L
----------------
T
F
C
G
T
L
A
Y
V
A
P
E
V
I
-----R
N
E
Y
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
--
S
--
G
-
S
T
Q
-
D
Q
L
Y
K
Q
I
G
R
G
S
--
Y
--
H
-
E
--
G
-
P
--
L
KDFR
I
--
S
E
E
A
R
D
---
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
-----
T
-----
A
A
K
----
A
L
N
H
P
W
I
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
51.13
34%
-83
- C3 -
-
4FSU
3
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
A
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
50.89
34%
-80
- C3 -
-
4FTK
2
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
50.78
34%
-79
- C3 -
-
4FSY
3
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
--------------------------
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
50.78
34%
-70
- C3 -
-
1ZLT
1
CHK1_HUMAN
A:
[9-276]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
50.75
35%
-72
- C3 -
-
2E9P
1
CHK1_HUMAN
A:
[8-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
50.72
34%
-74
- C3 -
-
2QHN
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
50.69
35%
-81
- C3 -
-
2X8E
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
50.70
35%
-98
- C3 -
-
4FG8
1
KCC1A_HUMAN
A:
[11-279]
-
K
Q
A
E
D
I
R
D
I
Y
D
F
R
D
V
L
G
T
G
A
F
S
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
A
K
---------------------------------
E
---
N
E
I
A
V
L
H
K
I
K
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
R
I
V
E
K
G
F
-
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSL
D
E
D
---
S
----
K
---
I
M
I
S
D
F
----------------------
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
-
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
D
-
E
N
D
-
A
K
L
F
E
Q
I
L
K
A
E
--
Y
EF
D
-
S
--
P
-
Y
--
W
DD--
I
--
S
D
S
A
K
D
---
F
I
R
H
L
M
E
K
D
P
E
K
R
F
-----
T
-----
C
E
Q
----
A
L
Q
H
P
W
I
A
-
G
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
50.69
34%
-77
- C3 -
-
1NVR
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
50.68
34%
-81
- C3 -
-
2C3L
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
-----------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
50.66
35%
-72
- C3 -
-
2YER
7
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
50.65
34%
-76
- C3 -
-
1NVQ
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
50.63
35%
-73
- C3 -
-
2YEX
8
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
50.61
34%
-78
- C3 -
-
4FTT
4
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
50.61
35%
-84
- C3 -
-
2JAM
3
KCC1G_HUMAN
B:
[9-265]
--------
K
T
F
I
F
M
E
V
L
G
S
G
A
F
S
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
K
-------------------------
S
S
-----
L
E
---
N
E
I
A
V
L
K
K
I
K
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
G
V
-
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
LTP
E
E
N
---
S
----
K
---
I
M
I
T
D
F
G
L
S
----
K
-
M
-
E
Q
N
G
I
M
S
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
--
A
Q
K
-
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
--
Y
--
E
-
E
T
E
-
S
K
L
F
E
K
I
K
E
G
Y
--
Y
--
E
-
F
ES
P
-
F
--
W
DD--
I
--
S
E
S
A
K
D
---
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
-----
T
-----
C
E
K
----
A
L
S
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
50.59
34%
-75
- C3 -
-
2R0U
1
CHK1_HUMAN
A:
[9-278]
----------
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
50.54
35%
-77
- C3 -
-
2E9V
1
CHK1_HUMAN
B:
[8-268]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
50.53
35%
-78
- C3 -
-
2E9U
1
CHK1_HUMAN
A:
[8-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
50.52
34%
-81
- C3 -
-
4FSM
3
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
50.50
34%
-74
- C3 -
-
2BRO
1
CHK1_HUMAN
A:
[9-276]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
50.48
35%
-74
- C3 -
-
2YDK
6
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
----------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
50.48
34%
-82
- C3 -
-
4FTL
2
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
50.46
35%
-81
- C3 -
-
2AYP
1
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
50.41
34%
-73
- C3 -
-
2HXL
1
CHK1_HUMAN
A:
[8-275]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
50.41
34%
-79
- C3 -
-
4FTM
5
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
50.40
35%
-74
- C3 -
-
2E9O
1
CHK1_HUMAN
A:
[8-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
50.38
34%
-77
- C3 -
-
3NLB
1
CHK1_HUMAN
A:
[9-271]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
----------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
50.35
34%
-79
- C3 -
-
2CGW
1
CHK1_HUMAN
A:
[9-271]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
---------------
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
50.29
34%
-74
- C3 -
-
2BRB
1
CHK1_HUMAN
A:
[9-276]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
50.25
34%
-73
- C3 -
-
4HYI
4
CHK1_HUMAN
A:
[9-274]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
---------------
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
50.23
34%
-30
- C3 -
-
2UZW
1
KAPCA_BOVIN
E:
[26-301]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
T
----
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
-----
V
N
D
----
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
50.22
34%
-70
- C3 -
-
2HXQ
1
CHK1_HUMAN
A:
[8-275]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
50.20
34%
-80
- C3 -
-
2CGU
1
CHK1_HUMAN
A:
[9-271]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
50.07
34%
-77
- C3 -
-
2CGV
1
CHK1_HUMAN
A:
[9-272]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
50.05
34%
-26
- C3 -
-
2UZV
1
KAPCA_BOVIN
A:
[26-301]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
T
----
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
-----
V
N
D
----
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
50.04
34%
-82
- C3 -
-
4RVL
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
50.00
35%
-81
- C3 -
-
2YIQ
1
CHK2_HUMAN
A:
[12-288]
----------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
--------------------------------
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
50.00
35%
-74
- C3 -
-
2YWP
1
CHK1_HUMAN
A:
[8-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
49.99
46%
-17
- C3 -
-
5T5T
2
AAPK1_RAT
A:
[15-500]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
-----
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
S
----
Q
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
49.98
35%
-32
- C3 -
-
2OJF
1
KAPCA_BOVIN
E:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
49.93
34%
-81
- C3 -
-
3PA3
1
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
49.92
34%
-81
- C3 -
-
2X8I
2
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
49.92
46%
-16
- C3 -
-
6E4W
2
?
A:
[15-490]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
-----
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
R
-----
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
49.85
34%
-83
- C3 -
-
2BRH
1
CHK1_HUMAN
A:
[9-271]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
49.84
34%
-75
- C3 -
-
2CGX
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
49.77
35%
-78
- C3 -
-
2E9V
1
CHK1_HUMAN
A:
[8-268]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
49.71
34%
-88
- C3 -
-
2WMX
1
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
49.68
35%
-31
- C3 -
-
2F7E
1
KAPCA_BOVIN
E:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
49.70
34%
-85
- C3 -
-
4FTR
3
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
E
--
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
49.68
34%
-29
- C3 -
-
2UZU
1
KAPCA_BOVIN
E:
[26-301]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
T
----
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
-----
V
N
D
----
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
49.67
34%
-82
- C3 -
-
3OT3
1
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-------------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
49.66
34%
-29
- C3 -
-
2UZT
1
KAPCA_BOVIN
A:
[26-301]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
T
----
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
-----
V
N
D
----
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
49.65
34%
-79
- C3 -
-
2WMR
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
49.62
34%
-80
- C3 -
-
3PA4
4
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
49.62
34%
-85
- C3 -
-
2WMV
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
49.62
34%
-79
- C3 -
-
2XEY
1
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
49.62
34%
-78
- C3 -
-
4HYH
1
CHK1_HUMAN
A:
[9-272]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
49.60
37%
2
- C3 -
-
4CZT
4
CIPKN_ARATH
D:
[13-306]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--
K
V
-----
L
--
K
--
N
KM
I
A
Q
-----
I
K
---
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
-
L
P
Q
-
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
--
F
--
T
-
C
--
P
-
P
--
W
----
F
--
S
A
S
A
K
K
---
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
-----
F
A
E
----
V
I
E
N
E
W
F
K
-
K
G
---
Y
K
A
P
---
K
F
E
N
A
D
V
S
----
L
D
D
V
D
A
----
I
F
D
D
S
----
N
LVVER
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
49.58
35%
-83
- C3 -
-
5F4N
8
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
49.53
35%
-26
- C3 -
-
2F7X
1
KAPCA_BOVIN
E:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
49.42
34%
-74
- C3 -
-
2BRM
1
CHK1_HUMAN
A:
[9-274]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
49.43
34%
-70
- C3 -
-
2GDO
1
CHK1_HUMAN
A:
[9-273]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
---------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
49.42
46%
-13
- C3 -
-
5KQ5
2
?
A:
[15-488]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
-----
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
S
----
R
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
49.38
34%
-77
- C3 -
-
2C3K
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
49.27
34%
-85
- C3 -
-
2YM6
6
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
49.24
46%
-11
- C3 -
-
6E4T
2
?
A:
[15-490]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
-----
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
R
-----
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
49.22
46%
-12
- C3 -
-
4QFS
2
AAPK1_RAT
A:
[15-490]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
-----
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
R
-----
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
49.21
37%
1
- C3 -
-
4CZT
3
CIPKN_ARATH
A:
[13-297]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--
K
V
-----
L
--
K
--
N
KM
I
A
Q
-----
I
K
---
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
-
L
P
Q
-
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
--
F
--
T
-
C
--
P
-
P
--
W
----
F
--
S
A
S
A
K
K
---
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
-----
F
A
E
----
V
I
E
N
E
W
F
K
-
K
G
---
Y
K
A
P
---
K
F
E
N
--
V
S
----
L
D
D
V
D
A
----
I
F
D
D
S
G
E
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
49.16
35%
-32
- C3 -
-
2F7Z
1
KAPCA_BOVIN
E:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
49.08
34%
-88
- C3 -
-
2WMW
1
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
------
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
49.07
34%
-80
- C3 -
-
3U9N
1
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
--------------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
49.02
34%
-86
- C3 -
-
2WMT
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
49.01
34%
-72
- C3 -
-
2BRN
1
CHK1_HUMAN
A:
[9-276]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
------------
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
48.97
33%
-33
- C3 -
-
5VJA
2
DAPK3_HUMAN
A:
[6-269]
---------
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--
R
-R----
G
--
V
--
S
--
R
E
E
-----
I
E
---
R
E
V
N
I
L
R
E
I
R
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
E
T
K
-
Q
E
T
L
T
N
I
S
A
V
N
--
Y
--
D
-
F
D-
E
-
E
--
Y
----
F
--
S
N
T
S
E
L
AKD
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
-----
I
A
Q
----
S
L
E
H
S
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
48.83
34%
-39
- C3 -
-
6BAB
2
KCC2D_MOUSE
C:
[15-275]
----------
Y
Q
L
F
E
E
L
G
K
G
A
F
S
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
I
N
T
-----
K
--
K
L
-----
S
--
A
R-
D
--
H
Q
K
-----
L
E
---
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
E
Y
-
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
K
---
S
----
K
GAA
V
K
L
A
D
F
G
L
A
I
-
E
V
Q
-
G
-
D
Q
Q
A
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
--
R
K
D
-
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
--
D
-
E
D
Q
-
H
R
L
Y
Q
Q
I
K
A
G
A
--
Y
--
D
-
F
PS
P
-
E
--
W
DT--
V
--
T
P
E
A
K
D
---
L
I
N
K
M
L
T
I
N
P
A
K
R
I
-----
T
-----
A
S
E
----
A
L
K
H
P
W
I
C
-
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
48.79
35%
-28
- C3 -
-
2OH0
1
KAPCA_BOVIN
E:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-----
R
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
48.77
34%
-77
- C3 -
-
5DLS
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
48.78
34%
-84
- C3 -
-
2YM5
2
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
48.77
37%
6
- C3 -
-
4CZU
3
CIPKN_ARATH
D:
[13-306]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--
K
V
-----
L
--
K
--
N
KM
I
A
Q
-----
I
K
---
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
-
L
P
Q
-
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
--
F
--
T
-
C
--
P
-
P
--
W
----
F
--
S
A
S
A
K
K
---
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
-----
F
A
E
----
V
I
E
N
E
W
F
K
-
K
G
---
Y
K
A
P
---
K
F
E
N
A
D
V
S
----
L
D
D
V
D
A
----
I
F
D
D
S
----
N
LVVER
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
48.74
46%
-17
- C3 -
-
4QFG
1
AAPK1_RAT
A:
[15-500]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
-----
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
R
----
P
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
48.70
46%
-15
- C3 -
-
6C9G
2
AAPK1_HUMAN
A:
[13-491]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
----
N
-
M
-
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
E
----
A
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
48.68
33%
-96
- C3 -
-
3ZXT
1
DAPK1_HUMAN
D:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
--------------------
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
-----
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
--------------
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
48.60
46%
-12
- C3 -
-
6C9J
2
AAPK1_HUMAN
A:
[13-491]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
----
N
-
M
-
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
P
----
F
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
48.54
46%
-10
- C3 -
-
4QFR
2
?
A:
[15-490]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
-----
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
R
-----
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
48.50
34%
-78
- C3 -
-
4JIK
1
CHK1_HUMAN
A:
[8-271]
----------
W
D
L
V
Q
T
L
G
E
G
A
-
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
48.48
37%
-1
- C3 -
-
4CZT
2
CIPKN_ARATH
B:
[13-295]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--
K
V
-----
L
--
K
--
N
KM
I
A
Q
-----
I
K
---
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
-
L
P
Q
-
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
--
F
--
T
-
C
--
P
-
P
--
W
----
F
--
S
A
S
A
K
K
---
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
-----
F
A
E
----
V
I
E
N
E
W
F
K
-
K
G
---
Y
K
A
P
---
K
F
E
----------
D
D
V
D
A
----
I
F
D
D
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
48.44
37%
3
- C3 -
-
4CZU
3
CIPKN_ARATH
A:
[13-302]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--
K
V
-----
L
--
K
--
N
KM
I
A
Q
-----
I
K
---
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
-
L
P
Q
-
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
--
F
--
T
-
C
--
P
-
P
--
W
----
F
--
S
A
S
A
K
K
---
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
-----
F
A
E
----
V
I
E
N
E
W
F
K
-
K
G
---
Y
K
A
P
---
K
F
E
N
---------
D
D
V
D
A
----
I
F
D
D
S
G
E
S
K
N
LVV---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
48.43
34%
-81
- C3 -
-
2YM4
4
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
------
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
48.38
34%
-84
- C3 -
-
4FTO
4
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
---------------------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
48.30
34%
-75
- C3 -
-
2C3J
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
----------------
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
48.27
34%
-85
- C3 -
-
2YM8
10
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
48.24
34%
-78
- C3 -
-
3PA5
4
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
----
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
48.22
46%
-12
- C3 -
-
5UFU
2
AAPK1_MOUSE (first)
A:
[15-500]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
-----
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
S
----
Q
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
48.12
34%
-86
- C3 -
-
2YM7
5
CHK1_HUMAN
A:
[9-271]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
48.11
37%
-7
- C3 -
-
4CZT
3
CIPKN_ARATH
C:
[13-295]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--
K
V
-----
L
--
K
--
N
KM
I
A
Q
-----
I
K
---
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
-
L
P
Q
-
Q
V
R
E
D
G
L
L
H
T
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
--
F
--
T
-
C
--
P
-
P
--
W
----
F
--
S
A
S
A
K
K
---
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
-----
F
A
E
----
V
I
E
N
E
W
F
K
-
K
G
---
Y
K
A
P
---
K
F
E
N
A
D
V
S
----
L
D
D
V
D
A
----
I
F
D
D
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
48.08
46%
-15
- C3 -
-
6C9F
2
AAPK1_HUMAN
A:
[13-491]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
----
N
-
M
-
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
I
----
R
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
48.04
35%
-79
- C3 -
-
2GHG
1
CHK1_HUMAN
A:
[8-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
A
-----
V
--
D
--
C
--
P
E
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
47.92
34%
-85
- C3 -
-
2WMS
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
-----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-----
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
47.89
37%
-2
- C3 -
-
4CZU
3
CIPKN_ARATH
C:
[13-294]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--
K
V
-----
L
--
K
--
N
KM
I
A
Q
-----
I
K
---
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
-
L
P
Q
-
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
--
F
--
T
-
C
--
P
-
P
--
W
----
F
--
S
A
S
A
K
K
---
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
-----
F
A
E
----
V
I
E
N
E
W
F
K
-
K
G
---
Y
K
A
P
---
K
F
E
N
A
---------
D
V
D
A
----
I
F
D
D
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
47.88
37%
-18
- C3 -
-
3HZT
9
?
A:
[6-297]
----------
Y
Q
R
V
K
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
-----
S
SV
T
T
-----
T
--
S
--
N
--
S
G
A
-----
L
L
---
D
E
V
A
V
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
L
R
Q
K
-
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
R
DAL
I
K
I
V
D
F
G
L
S
A
-
H
F
E
V------------
G
T
A
Y
Y
I
A
P
E
V
L
--
R
K
K
---
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
--
G
--
G
-
Q
T
D
-
Q
E
I
L
K
R
V
E
K
G
K
FS
F
--
D
-
P
--
P
-
D
--
W
TQ--
V
--
S
D
E
A
K
Q
---
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
-----
S
-----
A
E
E
----
A
L
N
H
P
W
I
V
-
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
47.82
34%
-85
- C3 -
-
2XEZ
7
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
47.79
34%
-85
- C3 -
-
2XF0
5
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
47.75
34%
-79
- C3 -
-
2WMQ
1
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
--------
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
47.73
37%
-0
- C3 -
-
4CZU
3
CIPKN_ARATH
B:
[13-295]
----------
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
-----
E
--
K
V
-----
L
--
K
--
N
KM
I
A
Q
-----
I
K
---
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
N
G
R
-
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
---
D
A
N
---
G
----
A
---
L
K
V
S
D
F
G
L
S
A
-
L
P
Q
-
Q
V
R
E
D
G
L
L
H
D
T
C
G
T
P
N
Y
V
A
P
E
V
I
--
N
N
K
-
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
--
E
--
D
-
S
N
L
-
T
S
L
Y
K
K
I
F
K
A
E
--
F
--
T
-
C
--
P
-
P
--
W
----
F
--
S
A
S
A
K
K
---
L
I
K
R
I
L
D
P
N
P
A
T
R
I
-----
T
-----
F
A
E
----
V
I
E
N
E
W
F
K
-
K
G
---
Y
K
A
P
---
K
F
E
----------
D
D
V
D
A
----
I
F
D
D
S
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
47.68
46%
-10
- C3 -
-
6E4U
2
AAPK1_RAT
A:
[15-488]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
N
-
M
-----
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
Q
----
S
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
47.60
34%
-83
- C3 -
-
3OT8
4
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
-----
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
47.52
34%
-87
- C3 -
-
2WMU
1
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
-----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
47.44
46%
-16
- C3 -
-
4CFH
1
AAPK1_RAT
A:
[32-489]
-------
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
R
-----
Q
--
K
I
-----
R
--
S
LD
V
--
V
G
K
-----
I
R
---
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
G
R
-
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
H
---
M
----
N
---
A
K
I
A
D
F
G
L
S
----
N
-
M
-
M
S
D
G
E
F
L
R
S
C
G
S
P
N
Y
A
A
P
E
V
I
--
S
G
R
-
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
--
D
-
D
H
V
-
P
T
L
F
K
K
I
C
D
G
I
--
F
--
Y
-
T
--
P
-
Q
--
Y
----
L
--
N
P
S
V
I
S
---
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
-----
T
-----
I
K
D
----
I
R
E
H
E
W
F
K
-
Q
D
LPK
Y
L
F
P
E
D
P
S
Y
S
S
T
M
I
------
D
D
-
E
A
----
L
K
E
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
47.28
31%
-20
- C3 -
-
4DEB
3
AURKA_HUMAN
A:
[8-266]
-------
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--
Q
L
EK---
A
--
G
--
V
--
E
H
Q
-----
L
R
---
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
A
---
G
----
E
---
L
K
I
A
D
F
G
W
S
V
H
A
P
S
-
S
-
R
R
D
----
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
--
E
G
R
-
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
--
A
-
N
T
Y
-
Q
E
T
Y
K
R
I
S
R
V
E
--
F
--
T
-
F
--
P
-
D
--
F
----
V
--
T
E
G
A
R
D
---
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
R
E
----
V
L
E
H
P
W
I
T
-
A
N
---
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
47.27
34%
-81
- C3 -
-
2YM3
6
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
---------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
--
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
47.20
35%
-55
- C3 -
-
3COK
1
PLK4_HUMAN
A:
[8-267]
-----
E
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
-----
K
--
A
M
YK---
A
--
G
--
M
--
V
Q
R
-----
V
Q
---
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
G
L
A
T
-
Q
L
K
-----------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
--
D
--
T
-
D
T
V
------
K
V
V
L
A
D
--
Y
--
E
-
M
--
P
-
S
--
F
----
L
--
S
I
E
A
K
D
---
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
-----
L
S
S
----
V
L
D
H
P
F
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
47.07
31%
-18
- C3 -
-
3UP2
3
AURKA_HUMAN
A:
[8-267]
-------
L
E
D
F
E
I
G
R
P
L
G
K
G
K
F
G
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
F
K
-----
A
--
Q
L
EK---
A
--
G
--
V
--
E
H
Q
-----
L
R
---
R
E
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
E
L
Q
K
L
S
K
-
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
A
---
G
----
E
---
L
K
I
A
D
F
G
W
S
V
H
A
P
S
-
S
-
R
R
D
----
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
--
E
G
R
-
M
H
-
D
E
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
--
A
-
N
T
Y
-
Q
E
T
Y
K
R
I
S
R
V
E
--
F
--
T
-
F
--
P
-
D
--
F
----
V
--
T
E
G
A
R
D
---
L
I
S
R
L
L
K
H
N
P
S
Q
R
P
-----
M
-----
L
R
E
----
V
L
E
H
P
W
I
T
-
A
N
---
S
S
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
46.96
35%
-45
- C3 -
-
2YCF
1
CHK2_HUMAN
A:
[12-288]
----------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
46.85
33%
-31
- C3 -
-
5VJA
3
DAPK3_HUMAN
D:
[6-269]
---------
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--
R
L
S-------
V
--
S
--
R
E
E
-----
I
E
---
R
E
V
N
I
L
R
E
I
R
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
---
E
K
E
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
-----VPNP
R
---
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
E
T
K
-
Q
E
T
L
T
N
I
S
A
V
N
--
Y
--
D
-
F
D-
E
-
E
--
Y
----
F
--
S
N
T
S
E
L
AKD
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
-----
I
A
Q
----
S
L
E
H
S
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
46.70
38%
-101
- C3 -
-
5XZV
1
RAD53_YEAST
A:
[200-465]
------------
I
D
E
V
V
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
I
I
S
K
-----
R
--
K
V
-----
I
--
G
--
N
--
M
D
G
-----
V
T
---
R
E
L
E
V
L
Q
K
L
N
H
P
R
I
V
R
L
K
G
F
Y
E
D
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
F
V
A
A
H
G
A
-
V
G
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
EQ-
D
D
P
---
V
----
L
---
V
K
I
T
D
F
G
L
-
A
-
K
-----------------
L
A
Y
V
A
P
E
V
I
------
N
E
Y
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
-------
S
T
Q
-
D
Q
L
Y
K
Q
I
G
R
G
S
---------------
L
KDFR
I
--
S
E
E
A
R
D
---
F
I
D
S
L
---
D
P
N
N
-------
T
-----
A
A
K
----
A
L
N
H
P
W
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
46.36
35%
-46
- C3 -
-
4JXF
2
PLK4_HUMAN
A:
[4-264]
-----
E
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
-----
K
--
A
M
YK---
A
--
G
--
M
--
V
Q
R
-----
V
Q
---
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
G
L
A
T
-
Q
L
K
-
M
-
P
H
------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---------
V
-
K
N
T
L
N
K
V
V
L
A
D
--
Y
--
E
-
M
--
P
-
S
--
F
----
L
--
S
I
E
A
K
D
---
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
-----
L
S
S
----
V
L
D
H
P
F
M
S
-
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
46.30
35%
-30
- C3 -
-
1XH9
4
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
-----
V
--
K
LK
E
--
I
E
H
-----
T
L
---
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
L
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
46.25
35%
-40
- C3 -
-
3L9M
1
KAPCA_HUMAN
B:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
46.14
35%
-39
- C3 -
-
2JDV
1
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
46.10
35%
-38
- C3 -
-
2GNH
2
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
46.03
35%
-62
- C3 -
-
3COK
1
PLK4_HUMAN
B:
[8-267]
-----
E
K
I
E
D
F
K
V
G
N
L
L
G
K
G
S
F
A
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
K
-----
K
--
A
M
YK---
A
--
G
--
M
--
V
Q
R
-----
V
Q
---
N
E
V
K
I
H
C
Q
L
K
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
N
---
M
----
N
---
I
K
I
A
D
F
G
L
A
T
-
Q
L
K
----------------------------------
L
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
------------
N
T
L
N
K
V
V
L
A
D
--
Y
--
E
-
M
--
P
-
S
--
F
----
L
--
S
I
E
A
K
D
---
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
-----
S
-----
L
S
S
----
V
L
D
H
P
F
M
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
46.02
34%
-77
- C3 -
-
4FTC
4
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
45.98
34%
-87
- C3 -
-
4FST
5
CHK1_HUMAN
A:
[8-269]
----------
W
D
L
V
Q
T
L
G
----
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
45.95
35%
-40
- C3 -
-
2GNF
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
45.93
35%
-39
- C3 -
-
1VEB
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
45.88
33%
10
- C3 -
-
2YAK
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
45.79
35%
-38
- C3 -
-
6E99
1
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
45.82
35%
-34
- C3 -
-
4BDF
3
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
45.79
35%
-31
- C3 -
-
4AXA
1
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
45.76
33%
9
- C3 -
-
2W4K
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
45.74
35%
-38
- C3 -
-
4Z84
1
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
45.67
35%
-35
- C3 -
-
1XH6
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
45.66
34%
-78
- C3 -
-
4FTA
4
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
---
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
45.63
35%
-34
- C3 -
-
2UW7
1
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
45.59
35%
-36
- C3 -
-
1Q8T
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
45.54
33%
8
- C3 -
-
4TXC
7
DAPK1_HUMAN
A:
[31-294]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
45.50
35%
-30
- C3 -
-
2JDT
1
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
45.52
33%
-38
- C3 -
-
5OQ5
2
CHK1_HUMAN
A:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--
R
---------------
C
P
E
N----
I
K
---
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
A
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
45.51
35%
-39
- C3 -
-
2GNJ
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
45.50
35%
-38
- C3 -
-
2GNL
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
45.47
34%
-78
- C3 -
-
4FSW
2
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
45.44
35%
-22
- C3 -
-
4Y5Q
1
?
A:
[30-302]
----------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
-----
A
--
S
A
K----
N
--
K
--
D
--
T
S
T
-----
I
L
---
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
E
S
K
---
E
----
K
DCD
I
K
I
I
D
F
G
L
S
T
-
C
F
Q
-
Q
-
N
T
-----
D
R
I
G
T
A
Y
Y
I
A
P
E
V
L
--
R
G
T
---
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
--
Y
--
G
-
K
N
E
-
Y
D
I
L
K
R
V
E
T
G
K
--
Y
AF
D
-
L
--
P
-
Q
--
W
RT--
I
--
S
D
D
A
K
D
---
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
-----
A
T
Q
----
C
L
E
H
P
W
I
Q
-
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
45.46
35%
-33
- C3 -
-
4Z83
2
KAPCA_BOVIN
E:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
45.45
35%
-34
- C3 -
-
3ZO4
4
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
45.44
36%
-3
- C3 -
-
3UPX
1
?
A:
[28-304]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--
Q
V
-----
K
QK
T
--
D
--
K
E
S
-----
L
L
---
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
DAN
I
R
I
I
D
F
G
L
S
T
-
H
F
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
--
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
-
L
--
P
-
Q
--
W
KK--
V
--
S
E
S
A
K
D
---
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
----
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
45.42
35%
-38
- C3 -
-
2VO7
2
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
45.41
33%
10
- C3 -
-
6FHB
2
DAPK1_HUMAN
A:
[15-278]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
45.39
35%
-38
- C3 -
-
2C1B
1
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
45.33
35%
-37
- C3 -
-
4BDG
2
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
45.31
36%
4
- C3 -
-
5W80
1
?
A:
[28-296]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--
Q
V
-----
K
QK
T
--
D
--
K
E
S
-----
L
L
---
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
DAN
I
R
I
I
D
F
G
L
S
T
-
H
F
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
--
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
-
L
--
P
-
Q
--
W
KK--
V
--
S
E
S
A
K
D
---
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
----
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
45.29
35%
-38
- C3 -
-
1XH5
3
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
45.28
36%
1
- C3 -
-
4MXA
1
?
A:
[29-292]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--
Q
V
-----
K
QK
T
--
D
--
K
E
S
-----
L
L
---
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
DAN
I
R
I
I
D
F
G
L
S
T
-
H
F
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
--
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
-
L
--
P
-
Q
--
W
KK--
V
--
S
E
S
A
K
D
---
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
----
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
45.23
34%
9
- C3 -
-
2XUU
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
A
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
45.19
35%
-32
- C3 -
-
2UVX
1
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
45.16
35%
-36
- C3 -
-
1Q8U
3
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
45.17
33%
18
- C3 -
-
1WVY
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
45.16
34%
-30
- C3 -
-
1XHA
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
-----
V
--
K
LK
E
--
I
E
H
-----
T
L
---
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
L
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
45.15
35%
-38
- C3 -
-
2GNI
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
I
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
A
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
45.08
35%
-30
- C3 -
-
2VO0
4
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
45.07
33%
13
- C3 -
-
2W4J
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
45.02
34%
-36
- C3 -
-
1Q24
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
44.94
35%
-38
- C3 -
-
3L9M
1
KAPCA_HUMAN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
44.97
35%
-33
- C3 -
-
1SVH
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
44.95
36%
3
- C3 -
-
3I7B
4
?
A:
[28-288]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--
Q
V
-----
K
QK
T
--
D
--
K
E
S
-----
L
L
---
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
DAN
I
R
I
I
D
F
G
L
S
T
-
H
F
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
--
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
-
L
--
P
-
Q
--
W
KK--
V
--
S
E
S
A
K
D
---
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
----
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
44.94
36%
1
- C3 -
-
3V5P
1
?
A:
[28-300]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--
Q
V
-----
K
QK
T
--
D
--
K
E
S
-----
L
L
---
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
DAN
I
R
I
I
D
F
G
L
S
T
-
H
F
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
--
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
-
L
--
P
-
Q
--
W
KK--
V
--
S
E
S
A
K
D
---
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
----
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
44.87
35%
-32
- C3 -
-
2YCQ
1
CHK2_HUMAN
A:
[12-288]
----------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
44.86
36%
1
- C3 -
-
3T3U
5
?
A:
[28-296]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--
Q
V
-----
K
QK
T
--
D
--
K
E
S
-----
L
L
---
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
DAN
I
R
I
I
D
F
G
L
S
T
-
H
F
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
--
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
-
L
--
P
-
Q
--
W
KK--
V
--
S
E
S
A
K
D
---
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
----
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
44.84
36%
-2
- C3 -
-
5JMS
2
?
A:
[69-343]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--
Q
V
-----
K
QK
T
--
D
--
K
E
S
-----
L
L
---
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
DAN
I
R
I
I
D
F
G
L
S
T
-
H
F
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
--
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
-
L
--
P
-
Q
--
W
KK--
V
--
S
E
S
A
K
D
---
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
----
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
44.83
35%
-19
- C3 -
-
3IGO
8
?
A:
[30-297]
----------------
L
G
K
G
S
F
G
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
K
-----
A
--
S
A
K----
N
--
K
-----
T
S
T
-----
I
L
---
R
E
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
K
R
-
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
E
S
K
---
E
----
K
DCD
I
K
I
I
D
F
G
L
S
T
-
C
F
Q
-
Q
-
N
T
---------
T
A
Y
Y
I
A
P
E
V
L
--
R
G
T
---
Y
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
--
Y
--
G
-
K
N
E
-
Y
D
I
L
K
R
V
E
T
G
K
--
Y
AF
D
-
L
--
P
-
Q
--
W
RT--
I
--
S
D
D
A
K
D
---
L
I
R
K
M
L
T
F
H
P
S
L
R
I
-----
T
-----
A
T
Q
----
C
L
E
H
P
W
I
Q
-
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
Blastp_CBE
44.77
35%
-39
- C3 -
-
4BDA
8
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
---
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
44.78
35%
-42
- C3 -
-
6FCF
1
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------------------N----
I
K
---
K
E
I
-
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
44.77
33%
8
- C3 -
-
4UV0
1
DAPK1_HUMAN
A:
[14-277]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
44.75
35%
-34
- C3 -
-
2YCR
1
CHK2_HUMAN
A:
[12-288]
----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
44.72
35%
-41
- C3 -
-
6E9L
1
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
44.71
35%
-32
- C3 -
-
2W7X
3
CHK2_HUMAN
A:
[12-288]
----------
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
44.67
35%
-36
- C3 -
-
4IE9
2
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
44.69
33%
13
- C3 -
-
4PF4
6
DAPK1_HUMAN
A:
[13-276]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
44.68
35%
-39
- C3 -
-
1XH8
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
44.67
35%
-28
- C3 -
-
2UW4
1
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
-
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
K
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
44.59
34%
-28
- C3 -
-
1SMH
6
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
-----
V
--
K
LK
E
--
I
E
H
-----
T
L
---
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
M
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
L
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
44.54
35%
-33
- C3 -
-
2XK9
1
CHK2_HUMAN
A:
[11-287]
----------
Y
I
M
S
K
T
L
G
S
G
A
-
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
44.56
35%
-38
- C3 -
-
4IJ9
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
44.54
36%
3
- C3 -
-
3N51
3
?
A:
[28-300]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--
Q
V
-----
K
QK
T
--
D
--
K
E
S
-----
L
L
---
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
DAN
I
R
I
I
D
F
G
L
S
T
-
H
F
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
--
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
-
L
--
P
-
Q
--
W
KK--
V
--
S
E
S
A
K
D
---
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
----
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
44.53
34%
-37
- C3 -
-
1CDK
2
KAPCA_PIG
B:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
-----
V
N
D
----
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
44.46
35%
-34
- C3 -
-
2C1A
1
KAPCA_BOVIN
A:
[41-316]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
44.45
35%
-38
- C3 -
-
1SVE
2
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
44.44
35%
-37
* C3 *
-
1SVG
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
44.39
33%
10
- C3 -
-
4B4L
3
DAPK1_HUMAN
A:
[14-277]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
44.38
36%
4
- C3 -
-
4IFG
1
?
A:
[51-320]
----------
Y
K
G
Q
R
V
L
G
K
G
S
F
G
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
S
K
-----
R
--
Q
V
-----
K
QK
T
--
D
--
K
E
S
-----
L
L
---
R
E
V
Q
L
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
K
R
-
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
---
E
S
K
---
S
----
K
DAN
I
R
I
I
D
F
G
L
S
T
-
H
F
E
-
A
-
S
K
--
K
M
K
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
--
H
G
T
---
Y
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
--
G
-
A
N
E
-
Y
D
I
L
K
K
V
E
K
G
K
--
Y
TF
E
-
L
--
P
-
Q
--
W
KK--
V
--
S
E
S
A
K
D
---
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
-----
S
-----
A
R
D
----
A
L
D
H
E
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
44.36
34%
-36
- C3 -
-
3DND
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
-----
V
N
D
----
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
44.33
34%
-84
- C3 -
-
4FTQ
3
CHK1_HUMAN
A:
[8-269]
----------
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------------
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
44.32
35%
-34
- C3 -
-
4BDH
4
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
44.30
35%
-40
- C3 -
-
2YCS
1
CHK2_HUMAN
A:
[12-288]
----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
44.25
33%
-34
- C3 -
-
5OQ7
1
CHK1_HUMAN
B:
[9-270]
----------
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
------------------------
C
P
E
N----
I
K
---
K
E
I
C
I
L
K
M
L
N
H
E
N
V
I
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
M
E
L
A
S
G
G
S
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
H
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
A
D
F
G
L
A
T
-
V
F
R
Y
N
-
N
R
E
R
L
L
N
K
M
C
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
44.19
34%
-37
- C3 -
-
3DNE
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
-----
V
N
D
----
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
44.16
33%
12
- C3 -
-
5AV3
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
44.11
33%
12
- C3 -
-
2Y0A
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
44.09
35%
-42
- C3 -
-
4BDD
3
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
44.05
34%
-35
- C3 -
-
1CDK
2
KAPCA_PIG
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
F
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
-----
V
N
D
----
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
43.97
34%
-35
- C3 -
-
4YXS
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
-----
V
N
D
----
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
44.00
35%
-41
- C3 -
-
2W0J
1
CHK2_HUMAN
A:
[12-289]
----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
43.98
33%
14
- C3 -
-
5AUT
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
43.97
33%
10
- C3 -
-
5AV4
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
43.94
33%
13
- C3 -
-
5AUZ
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
--
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
43.96
34%
-87
- C3 -
-
4FTN
4
CHK1_HUMAN
A:
[8-270]
----------
W
D
L
V
Q
T
L
G
E
-----
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
----------------------------
N
-----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
43.94
33%
-28
- C3 -
-
3ZXT
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRT---------------------
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
----VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
----------------
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
43.90
33%
14
- C3 -
-
5AV2
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
43.87
33%
11
- C3 -
-
5AV0
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
43.86
33%
-21
- C3 -
-
1O6L
1
AKT2_HUMAN
A:
[4-290]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
IA---
K
--
D
--
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
43.80
33%
-17
- C3 -
-
2JDR
1
AKT2_HUMAN
A:
[9-295]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
IA---
K
--
D
--
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
43.76
33%
16
- C3 -
-
6QMO
7
DAPK1_HUMAN
A:
[15-278]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
43.74
33%
-21
- C3 -
-
3E88
1
AKT2_HUMAN
B:
[4-284]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
-----
I
--
A
KD
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
43.66
33%
-22
- C3 -
-
1O6K
1
AKT2_HUMAN
A:
[4-286]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
-----
I
--
A
KD
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
43.63
33%
14
- C3 -
-
5AUY
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
43.60
33%
16
- C3 -
-
5AUX
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
43.50
33%
8
- C3 -
-
5AUW
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
43.44
35%
-11
- C3 -
-
4A9T
4
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------PALN-
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
43.42
33%
-22
- C3 -
-
3E88
1
AKT2_HUMAN
A:
[4-284]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
-----
I
--
A
KD
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
43.33
35%
-31
- C3 -
-
4BDC
2
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
---
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
43.32
33%
-19
- C3 -
-
2X39
1
AKT2_HUMAN
A:
[9-295]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
IA---
K
--
D
--
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
43.29
35%
-43
- C3 -
-
1STC
1
KAPCA_BOVIN
E:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
G----
N
-----
L
K
N
GVND
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
43.20
34%
-34
- C3 -
-
4YXR
1
KAPCA_BOVIN
A:
[40-315]
-------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
-----
Q
--
K
V
--------
V
--
K
--
L
K
Q
-----
I
E
HTL
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I
G
R
-
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
Q
---
G
----
Y
---
I
Q
V
T
D
F
G
F
A
K
-
R
V
K
-
G
-
R
-----
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
--
L
S
K
-
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
--
A
-
D
Q
P
-
I
Q
I
Y
E
K
I
V
S
G
K
--
V
--
R
-
F
--
P
-
S
--
H
----
F
--
S
S
D
L
K
D
---
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
GNLKD
G
-----
V
N
D
----
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
43.19
33%
15
- C3 -
-
5AUV
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
-
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
43.08
33%
-19
- C3 -
-
2UW9
1
AKT2_HUMAN
A:
[9-295]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
IA---
K
--
D
--
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
42.95
33%
-19
- C3 -
-
3E8D
1
AKT2_HUMAN
A:
[4-289]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
-----
I
--
A
KD
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
42.91
33%
-17
- C3 -
-
2JDO
2
AKT2_HUMAN
A:
[9-297]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
IA---
K
--
D
--
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
42.94
33%
-0
- C3 -
-
5VJA
2
DAPK3_HUMAN
C:
[6-269]
---------
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--
R
L
SS---
G
--
V
--
S
--
R
E
E
-----
I
E
---
R
E
V
N
I
L
R
E
I
R
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
--
E
K
E
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
-----VPNP
R
---
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
E
T
K
-
Q
E
T
L
T
N
I
S
A
V
N
--
Y
--
D
-
F
D-
E
-
E
--
Y
----
F
--
S
N
T
S
E
L
AKD
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
-----
I
A
Q
----
S
L
E
H
S
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
42.91
33%
-21
- C3 -
-
3E8D
1
AKT2_HUMAN
B:
[4-287]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
-----
I
--
A
KD
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
42.84
33%
-22
- C3 -
-
2XH5
1
AKT2_HUMAN
A:
[9-295]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
IA---
K
--
D
--
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
42.85
33%
-22
- C3 -
-
3E87
1
AKT2_HUMAN
A:
[4-282]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
-----
I
--
A
KD
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
42.84
35%
-24
- C3 -
-
4FT3
6
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
--------------------------
E
N----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
-
P
S
D
-
S
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
42.82
35%
-34
- C3 -
-
4BDJ
1
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
-----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------N----
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
---
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
42.70
33%
-23
- C3 -
-
3E87
1
AKT2_HUMAN
B:
[4-282]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
-----
I
--
A
KD
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
Blastp_CBE
42.65
35%
-8
- C3 -
-
2XM9
1
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------PALN-
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
42.36
33%
-22
- C3 -
-
3D0E
1
AKT2_HUMAN
A:
[4-281]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
-----
I
--
A
KD
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
42.34
33%
-22
- C3 -
-
3D0E
1
AKT2_HUMAN
B:
[4-281]
M
N
D
F
D
Y
L
-------
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
-----
E
--
V
I
-----
I
--
A
KD
E
--
V
A
H
-----
T
V
---
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
V
-
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
V
V
Y
R
D
I
K
L
E
N
L
M
L
---
D
K
D
---
G
----
H
---
I
K
I
T
D
F
G
L
C
K
---
E
-
G
-
I
S
D
G
A
T
M
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
--
E
D
N
-
D
Y
-
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
--
N
-
Q
D
H
-
E
R
L
F
E
L
I
L
M
E
E
--
I
--
R
-
F
--
P
-
R
--
T
----
L
--
S
P
E
A
K
S
---
L
L
A
G
L
L
K
K
D
P
K
Q
R
L
-----
G
GGPSD
A
K
E
----
V
M
E
H
R
F
F
L
-
S
--------
I
N
W
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
42.25
33%
9
- C3 -
-
3BHY
1
DAPK3_HUMAN
A:
[6-269]
---------
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--
R
L
SSSRR
G
--
V
--
S
--
R
E
E
-----
I
E
---
R
E
V
N
I
L
R
E
I
R
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
A
H
-
K
I
E
------------
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
E
T
K
-
Q
E
T
L
T
N
I
S
A
V
N
--
Y
--
D
-
F
D-
E
-
E
--
Y
----
F
--
S
N
T
S
E
L
AKD
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
-----
I
A
Q
----
S
L
E
H
S
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
42.24
35%
-3
- C3 -
-
2YIR
1
CHK2_HUMAN
A:
[12-288]
----------
Y
I
M
S
K
T
L
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------LN---
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
42.16
35%
-26
- C3 -
-
4GH2
4
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
-----------------------------N----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
-
P
S
D
-
S
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
42.09
33%
22
- C3 -
-
6AAR
1
DAPK1_HUMAN
A:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
--------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
-
F
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
Blastp_CBE
41.82
35%
-6
- C3 -
-
4A9R
2
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------PALN-
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
41.58
35%
-7
- C3 -
-
4A9U
10
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
G
S
----
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------DPALN
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
41.40
35%
-36
- C3 -
-
2YDJ
1
CHK1_HUMAN
A:
[9-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------------------N----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
Blastp_CBE
41.33
35%
-13
- C3 -
-
4A9S
1
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------PALN-
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
41.30
33%
1
- C3 -
-
3ZXT
1
DAPK1_HUMAN
C:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
--
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTKS
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
---------------
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
--
S
N
T
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
41.02
33%
13
- C3 -
-
5A6O
3
DAPK3_HUMAN
A:
[6-269]
---------
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--
R
L
SSSRR
G
--
V
--
S
--
R
E
E
-----
I
E
---
R
E
V
N
I
L
R
E
I
R
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
A
H
-
K
I
E
---------
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
E
T
K
-
Q
E
T
L
T
N
I
S
A
V
N
--
Y
--
D
-
F
D-
E
-
E
--
Y
----
F
--
S
N
T
S
E
L
AKD
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
-----
I
A
Q
----
S
L
E
H
S
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
40.88
35%
-36
- C3 -
-
2YDJ
1
CHK1_HUMAN
B:
[9-269]
----------
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
---------------------------N----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
40.78
33%
8
- C3 -
-
5A6N
1
DAPK3_HUMAN
B:
[6-269]
---------
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--
R
L
SSSRR
G
--
V
--
S
--
R
E
E
-----
I
E
---
R
E
V
N
I
L
R
E
I
R
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
A
H
-
K
I
E
---------
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
E
T
K
-
Q
E
T
L
T
N
I
S
A
V
N
--
Y
--
D
-
F
D-
E
-
E
--
Y
----
F
--
S
N
T
S
E
L
AKD
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
-----
I
A
Q
----
S
L
E
H
S
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
40.74
35%
-4
- C3 -
-
4BDB
10
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------LN---
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
---
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
40.68
33%
9
- C3 -
-
5A6O
2
DAPK3_HUMAN
B:
[6-269]
---------
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--
R
L
SSSRR
G
--
V
--
S
--
R
E
E
-----
I
E
---
R
E
V
N
I
L
R
E
I
R
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
A
H
-
K
I
E
---------
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
E
T
K
-
Q
E
T
L
T
N
I
S
A
V
N
--
Y
--
D
-
F
D-
E
-
E
--
Y
----
F
--
S
N
T
S
E
L
AKD
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
-----
I
A
Q
----
S
L
E
H
S
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
40.65
35%
7
- C3 -
-
4BDK
4
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------ALN--
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
40.50
33%
8
- C3 -
-
3BQR
4
DAPK3_HUMAN
A:
[6-269]
---------
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--
R
L
SSSRR
G
--
V
--
S
--
R
E
E
-----
I
E
---
R
E
V
N
I
L
R
E
I
R
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
N
-----
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
E
T
K
-
Q
E
T
L
T
N
I
S
A
V
N
--
Y
--
D
-
F
D-
E
-
E
--
Y
----
F
--
S
N
T
S
E
L
AKD
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
-----
I
A
Q
----
S
L
E
H
S
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
40.48
35%
-23
- C3 -
-
4FSZ
3
CHK1_HUMAN
A:
[8-277]
----------
W
D
L
V
Q
T
L
G
E
G
--
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
-----
K
--------------------
E
N----
I
K
---
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
D
I
G
-
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
---
D
E
R
---
D
----
N
---
L
K
I
S
D
F
G
L
A
T
-
V
F
R
-
Y
-
N
N
R
E
R
L
L
N
K
M
G
T
L
P
Y
V
A
P
E
L
L
--
K
R
R
-
E
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
--
D
--
Q
P
S
D
S
-
C
Q
E
Y
S
D
W
K
E
K
K
--
T
--
Y
-
L
--
N
-
P
--
W
KK--
I
--
D
S
A
P
L
A
---
L
L
H
K
I
L
V
E
N
P
S
A
R
I
-----
T
-----
I
P
D
----
I
K
K
D
R
W
--------
Y
N
K
P
L
K
K
G
A
K
R
P
R
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
40.47
33%
-17
- C3 -
-
3ZXT
1
DAPK1_HUMAN
B:
[12-275]
---------
Y
Y
D
T
G
E
E
L
G
S
G
Q
F
A
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
K
RRTK-
S
--
R
R
-----
G
--
V
--
S
--
R
E
D
-----
I
E
---
R
E
V
S
I
L
K
E
I
Q
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
R
---
N
VPKP
R
---
I
K
I
I
D
F
G
L
A
H
-
K
I
D
--------------
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
--
L
--
G
-
D
T
K
-
Q
E
T
L
A
N
V
S
A
V
N
--
Y
--
E
-
F
--
E
D
E
--
Y
----
F
-----
S
A
L
AKD
F
I
R
R
L
L
V
K
D
P
K
K
R
M
-----
T
-----
I
Q
D
----
S
L
Q
H
P
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
40.36
33%
21
- C3 -
-
5A6N
4
DAPK3_HUMAN
A:
[6-269]
---------
H
Y
E
M
G
E
E
L
G
S
G
Q
F
A
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
K
-----
R
--
R
L
SSSRR
G
--
V
--
S
--
R
E
E
-----
I
E
---
R
E
V
N
I
L
R
E
I
R
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
E
S
-
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
K
---
N
VPNP
R
---
I
K
L
I
D
F
G
I
A
H
-
K
I
E
-
A
-
G
N
E
F
--
K
N
I
F
G
T
P
E
F
V
A
P
E
I
V
--
N
Y
E
-
P
-
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
--
G
-
E
T
K
-
Q
E
T
L
T
N
I
S
A
V
N
--
Y
--
D
-
F
D-
E
-
E
--
Y
----
F
--
S
N
T
S
E
L
AKD
F
I
R
R
L
L
V
K
D
P
K
R
R
M
-----
T
-----
I
A
Q
----
S
L
E
H
S
W
I
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
40.29
35%
12
- C3 -
-
4BDI
6
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
G
----
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------ALN--
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
-
G
-
E
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
39.83
35%
2
- C3 -
-
4BDE
5
CHK2_HUMAN
A:
[18-294]
----------
Y
I
M
S
K
T
L
------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
K
---------------------------ALN--
V
E
---
T
E
I
E
I
L
K
K
L
N
H
P
C
I
I
K
I
K
N
F
F
D
-
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
K
R
-
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
---
S
S
Q
---
E
----
E
DCL
I
K
I
T
D
F
G
H
-
S
-
K
I
L
----
T
S
L
-
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
VS
V
G
T
-
A
G
Y
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
--
S
--
E
-
H
R
T
Q
V
S
L
K
D
Q
I
T
S
G
K
--
Y
--
N
F
I
--
P
-
E
V-
W
AE--
V
--
S
E
K
A
L
D
---
L
V
K
K
L
L
V
V
D
P
K
A
R
F
-----
T
-----
T
E
E
----
A
L
R
H
P
W
-
L
-
Q
D
---
E
D
M
K
R
K
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------