@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MET_HUMAN: (2020-09-15 )
MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEHHIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMALVVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECILTEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEFTTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKKTRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEFAVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVDTRPASFWETS
Atome Classification :
(507 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010.....---.1020......1030----......1040......1050......1060......1070...-------------------.----..1080-----......1090----....--.----.--1100--..----.....1110-..-....1120......1130..-....1140.....--.1150.-.-..--..-..1160.....-----.------1170--------.----------..----..------.-----...1180--------..--.--------...1190......1200......1210..--..----..1220....--..1230........1240.--.....1250......1260......1270......1280...--...1290......1300....----..---1310......1320......1330.-----------------.....1340...--...1350......1360......1370......1380......1390
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MKAPAVL
A
P
G
I
L
V
L
L
F
T
L
V
QRSN
G
E
C
K
E
A
L
A
KSEM
N
V
N
M
K
Y
QLPNFTAETP
I
Q
N
V
I
L
HEH
H
I
F
L
GAT
N
Y
I
Y
V
L
N
E
E
D
L
Q
K
V
A
EYKTGPVLEHPDCFP
C
Q
DCSSKANLSGGVWKDNI
N
M
A
L
V
V
DTYYDDQLISCGSVN
R
G
T
C
QRHVFPHNH
T
A
D
I
Q
S
E
V
H
C
I
FSPQIEEPSQ
C
P
D
C
V
V
S
A
L
G
A
K
V
L
S
S
V
K
D
R
F
I
N
F
F
VGNTINSSYFPDHPL
H
S
I
S
V
R
R
L
K
ETKD
G
F
M
F
LTD
Q
S
Y
I
D
V
L
P
E
F
R
DSYP
I
K
Y
V
H
A
FESN
N
F
I
Y
F
L
T
V
Q
RETLD
A
Q
T
F
H
T
R
I
I
R
F
CSI
N
S
G
L
H
S
Y
M
EM
P
L
E
C
I
L
T
E
K
R
KKRS
T
K
K
E
V
F
N
I
L
Q
A
A
YVSK
P
G
A
Q
L
A
R
Q
IGASLNDD
I
L
F
G
V
FAQSKPDSAEPMDRSAMCA
F
P
I
K
Y
V
N
D
F
F
N
K
I
VNKN
N
V
R
C
L
Q
H
FYGP
N
H
E
H
C
F
N
R
T
L
LRNSSGC
E
A
R
R
D
E
Y
R
T
E
F
T
T
A
L
Q
R
V
D
L
F
M
G
Q
F
S
E
V
L
L
T
S
I
S
T
F
IKG
D
L
T
I
A
NLGTSEG
R
F
M
Q
V
V
V
SRSGPST
P
H
V
N
F
L
LDSHPV
S
P
E
V
I
V
E
H
TLNQNG
Y
T
L
V
I
TG
K
K
I
T
KIPLNGL
G
C
R
H
F
Q
S
C
S
Q
C
LSAPP
F
V
Q
CG
W
C
H
D
K
CV
R
S
E
E
CLSGT
W
T
Q
Q
I
C
L
P
A
I
Y
K
VFPNSAPLEGG
T
R
L
T
I
C
GWDFGFRRNNKFD
L
K
K
T
R
V
L
LGNE
S
C
T
L
T
LSESTM
N
T
L
K
C
TVGPAMNKHF
N
M
S
I
I
I
SNGHGT
T
Q
YST
F
S
Y
V
D
P
V
I
T
SISPKYGPMAG
G
T
L
L
T
L
TGNYLNSGNS
R
H
I
S
IGG
K
T
C
T
L
K
S
V
S
N
S
I
L
E
CYTPAQTIS
T
E
F
A
V
K
L
K
I
D
LANRE
T
S
I
F
SYRED
P
I
V
Y
E
IHP
T
K
S
FISGG
S
T
I
T
GVGKNLNSVSV
P
R
M
V
I
N
V
HEAGRN
F
T
V
A
C
Q
HRSNS
E
I
I
C
CTTPS
L
Q
Q
L
N
L
QLPLK
T
K
A
F
F
M
L
D
G
I
L
S
K
Y
F
D
L
I
Y
VHNPVFKPFEK
P
V
M
I
SMGN
E
N
V
L
E
I
KGNDI
D
P
E
A
VK
G
E
V
L
KVGNKSC
E
N
I
H
LHS
E
A
V
L
C
TV
P
N
D
L
L
KLNSELN
I
E
W
K
Q
A
I
S
S
T
VL
G
K
V
I
VQPDQ
N
F
T
G
L
I
A
G
V
V
S
I
S
T
A
L
L
L
L
L
G
F
F
L
W
L
K
K
R
K
Q
I
K
D
L
G
S
E
L
V
R
Y
DARVH
T
P
H
L
D
R
L
V
S
ARSVSP
T
T
E
MVSNESV
D
Y
R
ATFPEDQFPNSSQN---GS
C
R
Q
V
QYPLTDM
S
P
----ILTSGDSDIS
S
P
L
L
Q
N
T
V
H
I
D
LSAL
N
P
E
L
V
Q
A
V
Q
H
V
VIGP
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----IGRGH
F
G
C
V
Y
----
H
G
T
L
--L----D--NDG---
K
K
----
I
H
C
A
V
K
S
L
N
-RI-T
D
I
G
E
V
S
Q
F
L
TEG
I
I
MKDFS-HP
N
V
L
S
L
L
G
I
C
L
R--SEG--S-
P
-
L
V
--
V
L
-PYMKH
G
D
L
R
N
F
-----
I
------R-----------N----------ET----HN------P-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
RNCMLDE
K
--
F
T
----
V
K
V
ADFG
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
VHNKTGAK--L
P
V
K
W
M
A
L
E
S
LQTQKFT
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
TRGAPPYPD--V
N
T
F
D
I
T
V
Y
L
LQG
R
R
LLQPEY----CP---
D
P
L
Y
E
V
M
L
K
CWH
P
K
A
EMRP
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
IG--E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
C
VAP
Y
P
S
L
LSSEDNADDEVDTRPASFWETS
58
Blastp_CBE
62.09
100%
-167
- C4 -
-
4XMO
1
A:
[4-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
-----------------
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
-----------------------------------------------
57
Blastp_CBE
61.87
100%
-163
- C4 -
-
4XYF
1
A:
[5-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
--------------
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
35
Blastp_CBE
61.78
100%
-169
- C4 -
-
3RHK
1
B:
[18-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
Q
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
60
Blastp_CBE
61.76
100%
-166
- C4 -
-
4DEH
1
A:
[6-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
-----------------
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
----
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
36
Blastp_CBE
61.41
100%
-164
- C4 -
-
3RHK
1
MET_HUMAN
A:
[21-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
30
Blastp_CBE
61.07
100%
-157
- C4 -
-
5DG5
1
B:
[22-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
56
Blastp_CBE
60.91
100%
-164
- C4 -
-
5EYC
1
A:
[6-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
--------------
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
-----------------------------------------------
83
Blastp_CBE
60.88
100%
-162
- C4 -
-
4R1V
4
A:
[1-291]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
----
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
-----------------------------------------------
59
Blastp_CBE
60.88
100%
-163
- C4 -
-
4DEI
1
A:
[6-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
---------
K
----
I
H
C
A
V
K
S
L
N
-
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
31
Blastp_CBE
60.77
100%
-157
- C4 -
-
5DG5
1
MET_HUMAN
A:
[22-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
76
Blastp_CBE
60.72
100%
-159
- C4 -
-
3F66
4
MET_HUMAN
A:
[1-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
--------------
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
-----
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
-----------------------------------------
61
Blastp_CBE
60.70
100%
-167
- C4 -
-
4DEG
1
A:
[5-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
-----------------
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
55
Blastp_CBE
60.70
100%
-160
- C4 -
-
5EYD
1
A:
[5-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
-----------------
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
----
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
------------------------------------------
28
Blastp_CBE
60.69
100%
-155
- C4 -
-
5HTI
1
A:
[25-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
-----
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
79
Blastp_CBE
60.34
99%
-153
- C4 -
-
3R7O
1
A:
[1-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
----
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
H
H
H
---------------------------------------
82
Blastp_CBE
60.23
100%
-160
- C4 -
-
2WD1
3
A:
[1-292]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
44
Blastp_CBE
60.17
99%
-161
- C4 -
-
6SDC
1
A:
[15-309]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
--------
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------------
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
V
M
Y
--
D
K
E
Y
Y
S
V
-----
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
62
Blastp_CBE
60.13
100%
-168
- C4 -
-
3U6I
1
A:
[4-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
--------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
---------------------------------------
32
Blastp_CBE
60.13
100%
-156
- C4 -
-
4MXC
1
A:
[25-319]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
-----
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
64
Blastp_CBE
60.01
100%
-168
- C4 -
-
3I5N
1
A:
[5-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
-----
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
80
Blastp_CBE
59.97
99%
-151
- C4 -
-
3Q6W
1
A:
[3-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
----
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
H
H
H
---------------------------------------
29
Blastp_CBE
59.93
100%
-158
- C4 -
-
5EOB
1
A:
[28-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
---
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
-----------------------------------------------
73
Blastp_CBE
59.90
99%
-159
- C4 -
-
2WGJ
1
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
-------------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
18
PsiBlast_PDB
59.74
99%
-144
- C4 -
-
3DKC
1
A:
[6-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
F
D
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
54
Blastp_CBE
59.70
100%
-171
- C4 -
-
5T3Q
1
?
A:
[3-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
--
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
----------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
---------------------------------------
37
Blastp_CBE
59.69
100%
-162
- C4 -
-
4EEV
1
A:
[16-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
L
L
Q
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
-----------------------
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
66
Blastp_CBE
59.68
99%
-158
- C4 -
-
4AOI
1
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
-------------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
68
Blastp_CBE
59.46
99%
-158
- C4 -
-
3ZXZ
1
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
-------------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
46
Blastp_CBE
59.42
99%
-168
- C4 -
-
3EFK
1
MET_HUMAN
A:
[8-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
---------------------------------------
40
Blastp_CBE
59.36
99%
-170
- C4 -
-
3DKG
1
A:
[5-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
------
C
V
Y
----
H
G
T
L
--
L
----
D
--------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
-----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
----------------------------------
70
Blastp_CBE
59.33
99%
-155
- C4 -
-
3ZC5
1
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
-------------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
65
Blastp_CBE
59.33
99%
-154
- C4 -
-
4AP7
1
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
-------------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
63
Blastp_CBE
59.32
100%
-164
- C4 -
-
3U6H
1
A:
[4-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
---------------------------------------
72
Blastp_CBE
59.29
99%
-150
- C4 -
-
2WKM
1
A:
[10-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
20
PsiBlast_PDB
59.21
99%
-156
- C4 -
-
1R0P
1
A:
[2-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
---------
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
F
D
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
--------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
17
PsiBlast_PDB
59.20
99%
-165
- C4 -
-
3C1X
1
A:
[63-373]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
---------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
69
Blastp_CBE
59.15
99%
-154
- C4 -
-
3ZCL
1
A:
[3-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
-------------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
19
PsiBlast_PDB
59.06
99%
-165
- C4 -
-
3DKF
1
A:
[5-315]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
----------------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
---------------
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
48
Blastp_CBE
59.02
99%
-165
- C4 -
-
3EFJ
1
MET_HUMAN
A:
[8-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
---------------------------------------
16
PsiBlast_PDB
59.01
99%
-158
- C4 -
-
3L8V
1
A:
[8-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
------------------
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
49
Blastp_CBE
58.98
99%
-162
- C4 -
-
3CD8
1
A:
[8-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
-----------------
K
----
I
H
C
A
V
K
S
L
N
-
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
---------
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
-
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
67
Blastp_CBE
58.96
99%
-148
- C4 -
-
3ZZE
1
A:
[10-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
42
Blastp_CBE
58.90
99%
-164
- C4 -
-
3QTI
1
MET_HUMAN
A:
[6-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
---------
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
F
------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
-----
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
11
PsiBlast_PDB
58.84
99%
-146
- C4 -
-
3VW8
1
A:
[1-328]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
Y
P
L
T
D
M
S
P
----
I
L
T
S
G
D
--------------
D
L
S
-
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
------
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
-------
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
--------------------------------------
14
PsiBlast_PDB
58.80
99%
-164
- C4 -
-
3CE3
1
A:
[8-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
------------------
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
77
Blastp_CBE
58.68
99%
-161
- C4 -
-
3LQ8
1
A:
[5-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
--------
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
----
D
K
E
Y
Y
S
------
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
-----------------------------------------------
53
Blastp_CBE
58.48
99%
-177
- C4 -
-
2RFN
1
MET_HUMAN
A:
[11-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
----
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
-----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
---------------------------------------
45
Blastp_CBE
58.40
99%
-164
- C4 -
-
3EFK
1
B:
[8-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
------
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
---------------------------------------
87
Blastp_CBE
58.39
100%
-167
- C4 -
-
4KNB
3
MET_HUMAN
A:
[5-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
--------------
K
----
I
H
C
A
V
K
S
L
-----
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
50
Blastp_CBE
58.30
99%
-163
- C4 -
-
3CCN
1
A:
[9-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
-----------------
K
----
I
H
C
A
V
K
S
L
N
-
R
------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
-
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
74
Blastp_CBE
58.07
99%
-152
- C4 -
-
5HLW
1
A:
[1-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
-
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
-
H
F
G
C
V
Y
----
H
G
T
L
--
L
--------
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
--
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
---------
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
H
--
D
K
E
Y
Y
S
V
-----
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
-----------------------------------
13
PsiBlast_PDB
58.01
99%
-162
- C4 -
-
3CTJ
1
A:
[5-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
---------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
12
PsiBlast_PDB
57.94
99%
-158
- C4 -
-
3CTH
1
A:
[6-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
------------------
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
71
Blastp_CBE
57.64
99%
-149
- C4 -
-
3ZBX
1
A:
[10-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
-------------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
27
Blastp_CBE
57.42
100%
-162
- C4 -
-
5YA5
1
A:
[30-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
-------------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
--------
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
---------
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
-----------------------------------------------
33
Blastp_CBE
57.40
100%
-149
- C4 -
-
4GG7
1
A:
[37-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
52
Blastp_CBE
57.28
99%
-166
- C4 -
-
2RFN
1
B:
[10-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
----
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
-----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
---------------------------------------
26
Blastp_CBE
57.27
100%
-164
- C4 -
-
6SD9
1
MET_HUMAN
A:
[25-308]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
---------
E
Y
Y
S
----
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
-----------------------------------------------
47
Blastp_CBE
57.25
99%
-160
- C4 -
-
3EFJ
1
B:
[8-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
-----------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
---------------------------------------
15
PsiBlast_PDB
57.23
99%
-159
- C4 -
-
3F82
1
A:
[9-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
--------------
K
----
I
H
C
A
V
K
S
L
N
-
R
-----
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
-----------------------
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
41
Blastp_CBE
57.20
99%
-167
- C4 -
-
3QTI
2
B:
[12-314]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
-------------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
F
------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
------
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
34
Blastp_CBE
57.11
100%
-154
- C4 -
-
4GG5
1
A:
[37-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
----
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
85
Blastp_CBE
57.05
100%
-161
- C4 -
-
4KNB
2
MET_HUMAN
C:
[1-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
----------------------
I
H
C
A
V
K
S
L
N
-
R
----
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
---------
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
--
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
43
Blastp_CBE
57.00
99%
-160
- C4 -
-
6SDD
2
A:
[25-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
--
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
---------
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
V
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
------------------------------------------------
10
PsiBlast_PDB
56.87
100%
-148
- C4 -
-
5UAD
1
A:
[12-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
M
S
P
----
I
------------------------
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
-----------------------
H
C
A
V
K
S
L
N
------
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
9
PsiBlast_PDB
56.80
100%
-153
- C4 -
-
5UAB
2
A:
[12-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
D
M
S
P
----
I
------------------------
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
-----------------------
H
C
A
V
K
S
L
N
---------
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
81
Blastp_CBE
56.76
100%
-164
- C4 -
-
4R1Y
3
A:
[8-292]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
-------------------
I
H
C
A
V
K
S
L
N
----------
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
--------
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
--
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
75
Blastp_CBE
56.73
100%
-160
- C4 -
-
3F66
3
B:
[11-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
-------------
K
K
----
I
H
C
A
V
K
S
L
N
--------
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
-------
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
------
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
-----------------------------------------
51
Blastp_CBE
56.70
99%
-160
- C4 -
-
2RFS
1
A:
[21-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
-----------------
K
----
I
H
C
A
V
K
S
L
N
------
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
--------
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
--
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
25
Blastp_CBE
56.66
100%
-154
- C4 -
-
6SDE
1
A:
[31-309]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
--------------
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-----
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
----
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
K
T
G
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
24
Blastp_CBE
56.28
99%
-154
- C4 -
-
3A4P
3
A:
[22-319]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--------
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
----------
A
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
------------------------------
86
Blastp_CBE
55.66
100%
-164
- C4 -
-
4KNB
2
MET_HUMAN
B:
[8-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
--------------
K
----
I
H
C
A
V
K
S
--------
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
-----------
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
---------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
84
Blastp_CBE
55.05
100%
-169
- C4 -
-
4KNB
1
D:
[5-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
----
G
---
K
K
----
I
H
C
A
V
K
S
L
------
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
----
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
---------------------
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
----------
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
-------
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
----------------------------------------------
90
Blastp_CBE
54.46
61%
-151
- C4 -
-
3PLS
1
A:
[3-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
A
L
L
A
E
V
K
D
V
L
I
P
H
E
R
V
-------------------
V
----
T
H
S
D
R
V
-----
I
G
K
G
H
F
G
V
V
Y
----
H
G
E
Y
--
I
----
D
--
Q
A
Q
---
N
R
----
I
Q
C
A
I
K
S
L
S
-
R
I
-
T
E
M
Q
Q
V
E
A
F
L
R
E
G
L
L
M
R
G
L
N
-
H
P
N
V
L
A
L
I
G
I
M
L
P
--
P
E
G
--
L
-
P
-
H
V
--
L
L
-
P
Y
M
C
H
G
D
L
L
Q
F
-----
I
------
R
-----------
S
----------
P
Q
----
R
N
------
P
-----
T
V
K
D
L
I
S
--------
F
G
--
L
--------
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
S
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
I
L
--
D
R
E
Y
Y
S
V
Q
Q
H
R
H
A
R
--
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
G
A
P
P
Y
R
H
--
I
D
P
F
D
L
T
H
F
L
A
Q
G
R
R
L
P
Q
P
E
Y
----
C
P
---
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
R
V
L
V
-----------------
G
E
V
E
Q
I
V
S
A
L
L
G
--
D
H
Y
V
Q
L
--------------------------------------
23
Blastp_CBE
52.50
99%
-161
- C4 -
-
5HNI
1
MET_HUMAN
X:
[15-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
--------------------------------------------
G
C
V
Y
----
H
G
T
L
-----------------
K
----
I
H
C
A
V
K
S
-----------
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
----------------------
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
----------------------------------
39
Blastp_CBE
52.15
99%
-153
- C4 -
-
5HOR
1
A:
[16-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
--------------------------------------------
G
C
V
Y
----
H
G
T
L
-----------------
K
----
I
H
C
A
V
K
S
-----------
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
-------------------
L
P
V
K
W
T
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
----------------------------------
21
Blastp_CBE
51.89
99%
-159
- C4 -
-
5HO6
1
A:
[15-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
---------------------------------------------
C
V
Y
----
H
G
T
L
----------------------
I
H
C
A
V
K
S
-----------
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
------
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
-----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
----------------------------------
22
Blastp_CBE
51.86
99%
-160
- C4 -
-
5HNI
1
Y:
[15-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
--------------------------------------------
G
C
V
Y
----
H
G
T
L
-----------------
K
----
I
H
C
A
V
K
S
-----------
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
----------------------
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
----------------------------------
38
Blastp_CBE
49.09
99%
-149
- C4 -
-
5HOA
1
A:
[17-308]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
H
V
V
-------------------------------------------------
V
Y
----
H
G
T
L
-----------------
K
----
I
H
C
A
V
K
--------------
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
-------------------
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
F
V
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
-----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
Y
V
H
V
N
A
T
Y
----------------------------------
389
Blastp_CBE
48.28
36%
-156
- C4 -
-
6I8Z
1
A:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
R
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
392
Blastp_CBE
48.27
36%
-151
- C4 -
-
2ETM
1
B:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
R
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
418
Blastp_CBE
48.22
36%
-154
- C4 -
-
3PXK
1
B:
[15-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
414
Blastp_CBE
48.12
36%
-160
- C4 -
-
4KAO
1
B:
[15-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
-----
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
550
Blastp_CBE
48.11
36%
-148
- C4 -
-
4D58
1
?
B:
[12-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
F
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
--
D
C
----
V
K
L
G
D
F
G
L
S
R
--
Y
M
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
412
Blastp_CBE
48.02
36%
-156
- C4 -
-
4I4E
1
A:
[17-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
-
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
---------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
404
Blastp_CBE
48.01
36%
-150
- C4 -
-
4GU9
1
B:
[15-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
-----
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
R
--
Y
M
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
390
Blastp_CBE
47.99
36%
-154
- C4 -
-
2IJM
1
B:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
415
Blastp_CBE
47.88
36%
-159
- C4 -
-
4KAO
1
FAK1_HUMAN
A:
[15-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--------
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
393
Blastp_CBE
47.82
36%
-150
- C4 -
-
2ETM
1
FAK1_HUMAN
A:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
R
--
Y
M
E
---------------
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
547
Blastp_CBE
47.81
36%
-159
- C4 -
-
4D5K
1
FAK1_CHICK
A:
[12-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
F
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
--
D
C
----
V
K
L
G
D
F
------------------------
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
549
Blastp_CBE
47.67
36%
-156
- C4 -
-
4D5H
1
FAK1_CHICK
A:
[12-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
M
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
F
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
--
D
C
----
V
K
L
G
D
F
------------------------
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
545
Blastp_CBE
47.62
36%
-150
- C4 -
-
6GCX
1
FAK1_CHICK
A:
[12-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
M
A
V
A
I
K
T
C
K
-
N
---
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
F
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
A
T
--
D
C
----
V
K
L
G
D
F
G
L
S
R
-----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
403
Blastp_CBE
47.61
36%
-154
- C4 -
-
4K8A
1
FAK1_HUMAN
A:
[15-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
-----
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
391
Blastp_CBE
47.59
36%
-153
- C4 -
-
2IJM
1
FAK1_HUMAN
A:
[14-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
494
Blastp_CBE
47.56
36%
-157
- C4 -
-
4EBW
1
A:
[40-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
----
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
----------------------
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
410
Blastp_CBE
47.45
36%
-156
- C4 -
-
4Q9S
1
A:
[17-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
-----
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
----------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
495
Blastp_CBE
47.40
36%
-157
- C4 -
-
4EBV
3
A:
[40-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
----------------------
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
394
Blastp_CBE
47.33
36%
-149
- C4 -
-
2JKQ
1
A:
[12-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
402
Blastp_CBE
47.28
36%
-148
- C4 -
-
4K8A
1
B:
[15-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
R
--
Y
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
417
Blastp_CBE
47.22
36%
-141
- C4 -
-
4GU6
1
FAK1_HUMAN
A:
[15-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
----
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
R
--
Y
M
E
--
D
S
T
Y
Y
K
A
---
S
K
G
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
411
Blastp_CBE
47.20
36%
-156
- C4 -
-
4I4F
2
A:
[17-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--------
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
---------------------
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
409
Blastp_CBE
47.07
36%
-152
- C4 -
-
3BZ3
1
A:
[9-267]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
-----------
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
R
--
Y
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
401
Blastp_CBE
47.03
36%
-144
- C4 -
-
4K9Y
1
A:
[15-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
E
N
---
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
F
G
L
S
R
--
Y
M
E
--
D
S
T
Y
Y
K
A
---
S
K
G
K
--
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
413
Blastp_CBE
46.59
36%
-150
- C4 -
-
1MP8
1
A:
[17-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
L
G
R
C
-----
I
G
E
G
Q
F
G
D
V
H
----
Q
G
I
Y
--
M
----
S
--
P
-----
P
A
----
L
A
V
A
I
K
T
C
K
-
N
C
-
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
D
-
H
P
H
I
V
K
L
I
G
V
I
----
T
E
N
--
P
-
V
-
W
I
--
I
M
-
E
L
C
T
L
G
E
L
R
S
F
-----
L
------
Q
-----------
V
----------
R
K
----
Y
S
------
L
-----
D
L
A
S
L
I
L
--------
Y
A
--
Y
--------
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
S
N
--
D
C
----
V
K
L
G
D
----------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
G
V
K
P
F
Q
G
--
V
K
N
N
D
V
I
G
R
I
E
N
G
E
R
L
P
M
P
P
N
----
C
P
---
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
-----------------
A
Q
L
S
T
I
L
---------------------------------------------------
388
Blastp_CBE
46.16
36%
-129
- C4 -
-
3KUL
1
B:
[51-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
H
I
E
K
I
-----
I
G
S
G
D
S
G
E
V
C
----
Y
G
R
L
--
R
----
V
--
P
G
Q
---
R
D
----
V
P
V
A
I
K
A
L
K
-
A
G
-
Y
T
E
R
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
R
--
G
R
L
--
A
---
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
T
F
-----
L
------
R
-----------
T
----------
H
D
----
G
Q
------
F
-----
T
I
M
Q
L
V
G
--------
M
L
--
R
--------
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
D
P
--
D
A
A
T
T
T
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
--
M
T
N
R
D
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
----
C
P
---
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
-----------------
S
V
L
D
A
L
I
R
S
-------------------------------------------------
500
Blastp_CBE
45.63
38%
-132
- C4 -
-
2QOC
2
A:
[18-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
D
K
V
-----
V
G
A
G
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
S
K
---
K
E
----
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
--
S
K
---
P
-
V
-
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
K
----------
H
D
----
A
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
------------
K
--
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
--
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
-----------------
S
---------------------------------------------------------
377
Blastp_CBE
45.63
36%
-132
- C4 -
-
3KUL
2
EPHA8_HUMAN
A:
[51-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
H
I
E
K
I
-----
I
G
S
G
D
S
G
E
V
C
----
Y
G
R
L
--
R
----
V
--
P
G
Q
---
R
D
----
V
P
V
A
I
K
A
L
K
-
A
G
-
Y
T
E
R
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
R
--
G
R
L
--
A
---
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
T
F
-----
L
------
R
-----------
T
----------
H
D
----
G
Q
------
F
-----
T
I
M
Q
L
V
G
--------
M
L
--
R
--------
G
V
G
A
G
M
R
Y
L
S
D
L
G
Y
V
H
R
D
L
A
A
R
N
V
L
V
D
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
-------
A
A
Y
T
T
T
-----
I
P
I
R
W
T
A
P
E
A
I
A
F
R
T
F
S
S
A
S
D
V
W
S
F
G
V
V
M
W
E
V
L
A
Y
G
E
R
P
Y
W
N
--
M
T
N
R
D
V
I
S
S
V
E
E
G
Y
R
L
P
A
P
M
G
----
C
P
---
H
A
L
H
Q
L
M
L
D
C
W
H
K
D
R
A
Q
R
P
R
F
S
Q
I
V
-----------------
S
V
L
D
A
L
I
R
S
-------------------------------------------------
380
Blastp_CBE
45.61
38%
-132
- C4 -
-
6IN0
2
?
A:
[10-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
D
K
V
-----
V
G
A
G
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
S
K
---
K
E
----
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
--
S
K
---
P
-
V
-
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
K
----------
H
D
----
A
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
-------------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
--
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
-----------------
S
---------------------------------------------------------
516
Blastp_CBE
45.22
38%
-131
- C4 -
-
4P5Q
1
A:
[35-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
D
K
V
-----
V
G
A
G
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
S
K
---
K
E
----
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
--
S
K
---
P
-
V
-
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
K
----------
H
D
----
A
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
-----------------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
--
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
-----------------
S
---------------------------------------------------------
517
Blastp_CBE
44.86
38%
-133
- C4 -
-
4P4C
1
A:
[35-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
D
K
V
-----
V
G
A
G
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
S
K
---
K
E
----
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
--
S
K
---
P
-
V
-
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
K
----------
H
D
----
A
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
--
L
V
----
C
K
V
S
D
F
----------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
--
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
-----------------
S
---------------------------------------------------------
515
Blastp_CBE
44.84
38%
-134
- C4 -
-
4P5Z
1
A:
[35-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
D
K
V
-----
V
G
A
G
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
S
K
---
K
E
----
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
--
S
K
---
P
-
V
-
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
K
----------
H
D
----
A
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
--
L
V
----
C
K
V
S
D
F
----------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
--
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
-----------------
S
---------------------------------------------------------
512
Blastp_CBE
44.77
38%
-132
- C4 -
-
2QOK
1
A:
[47-307]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
D
K
V
-----
V
G
A
G
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
S
K
---
K
E
----
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
--
S
K
---
P
-
V
-
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
K
----------
H
D
----
A
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
A
R
--
V
--------------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
--
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
-----------------
S
---------------------------------------------------------
522
Blastp_CBE
44.75
38%
-133
- C4 -
-
3DZQ
1
A:
[35-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
D
K
V
-----
V
G
A
G
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
S
K
---
K
E
----
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
--
S
K
---
P
-
V
-
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
K
----------
H
D
----
A
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
--
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
-----------------
S
---------------------------------------------------------
521
Blastp_CBE
44.43
38%
-129
- C4 -
-
4G2F
1
A:
[35-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
D
K
V
-----
V
G
A
G
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
S
K
---
K
E
----
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
--
S
K
---
P
-
V
-
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
K
----------
H
D
----
A
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
--------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
--
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
-----------------
S
---------------------------------------------------------
513
Blastp_CBE
44.14
38%
-129
- C4 -
-
4TWO
1
A:
[35-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
D
K
V
-----
V
G
A
G
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
S
K
---
K
E
----
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
--
S
K
---
P
-
V
-
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
K
----------
H
D
----
A
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
--------------------
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
--
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
-----------------
S
---------------------------------------------------------
514
Blastp_CBE
43.63
38%
-128
- C4 -
-
4TWN
1
A:
[35-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
D
K
V
-----
V
G
A
G
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
S
K
---
K
E
----
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
--
S
K
---
P
-
V
-
M
I
--
V
T
-
E
Y
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
K
----------
H
D
----
A
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--------------------
K
--
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
--
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
-----------------
S
---------------------------------------------------------
112
Blastp_CBE
41.60
45%
-90
- C4 -
-
3BPR
1
MERTK_HUMAN
B:
[25-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
-
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
K
-
L
-------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M--------
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
L
S
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
109
Blastp_CBE
41.03
45%
-77
- C4 -
-
3BRB
2
MERTK_HUMAN
A:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
-
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
----N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
-------
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
L
S
------------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
91
Blastp_CBE
40.56
45%
-73
- C4 -
-
5U6C
1
B:
[26-312]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
---
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
----------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
M
R
L
L
G
V
C
I
E
MS
S
Q
G
IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
---------------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
95
Blastp_CBE
40.50
45%
-82
- C4 -
-
6MEP
1
MERTK_HUMAN
A:
[25-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
-------------
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
----------
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
L
S
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
110
Blastp_CBE
40.09
45%
-70
- C4 -
-
3BPR
1
D:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
K
---------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
MS
S
------
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
L
S
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
113
Blastp_CBE
40.01
45%
-70
- C4 -
-
3BPR
1
MERTK_HUMAN
A:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
K
-------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
MS
S
------
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
L
S
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
111
Blastp_CBE
39.84
45%
-69
- C4 -
-
3BPR
1
MERTK_HUMAN
C:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
K
---------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
MS-----
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
L
S
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
115
Blastp_CBE
39.29
45%
-66
- C4 -
-
2P0C
2
MERTK_HUMAN
A:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
--
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
------------
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
-------IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
L
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
114
Blastp_CBE
39.00
45%
-64
- C4 -
-
2P0C
1
B:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
---
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
------------
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
-------IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
L
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
376
Blastp_CBE
38.91
39%
-68
- C4 -
-
2REI
1
A:
[45-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
I
E
R
V
-----
I
G
A
G
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
G
K
---
R
D
----
V
A
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
C
E
A
S
I
M
G
Q
F
D
-
H
P
N
V
V
H
L
E
G
V
V
T
R
----
G
--
K
-
P
V
M
I
--
V
I
-
E
F
M
E
N
G
A
L
D
A
F
-----
L
------
R
-----------
K
----------
H
D
----
G
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
--------------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
--
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
A
P
M
D
----
C
P
---
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
E
Q
I
V
-----------------
G
---------------------------------------------------------
311
Blastp_CBE
38.84
42%
-74
- C4 -
-
3GVU
2
ABL2_HUMAN
A:
[40-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
L
---
E
P
--
P
-
F
-
Y
I
--
V
T
-
E
Y
M
P
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
E
E
------
V
-----
T
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
V
----
V
K
V
A
D
F
G
L
S
R
--------
G
D
T
Y
T
------
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
----
C
P
---
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
199
Blastp_CBE
38.82
41%
-73
- C4 -
-
3IK3
1
ABL1_MOUSE
A:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
-----------
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
108
Blastp_CBE
38.81
45%
-54
- C4 -
-
3BRB
2
B:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
MS
S
Q
G
IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
L
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
123
Blastp_CBE
38.74
41%
-82
- C4 -
-
3QUP
1
A:
[16-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
P
---
F
-------------------
T
----
L
--
G
R
M
-----
L
G
K
G
E
F
G
S
V
R
----
E
A
Q
L
----------------------
V
K
V
A
V
K
M
L
-------
S
S
D
I
E
E
F
L
R
E
A
A
C
M
K
E
F
D
-
H
P
H
V
A
K
L
V
G
V
S
L
R
--
S
-----I
P
-
M
V
--
I
L
-
P
F
M
K
H
G
D
L
H
A
F
LLASR
I
------------------------------
P
----
F
N
------
L
-----
P
L
Q
T
L
V
R
--------
F
M
--
V
--------
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
--
M
T
----
V
C
V
A
D
F
G
L
-------------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
--
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
----
C
M
---
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
-----------------
M
E
L
E
N
I
L
G
--------------------------------------------------
240
Blastp_CBE
38.68
41%
-66
- C4 -
-
3KFA
1
ABL1_MOUSE
B:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
104
Blastp_CBE
38.67
45%
-86
- C4 -
-
4M3Q
1
B:
[26-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
-----
G
S
V
M
----
E
G
N
L
--
K
--------------
S
----
L
K
V
A
V
K
T
M
-------------
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
--------
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
---------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
198
Blastp_CBE
38.64
41%
-69
- C4 -
-
3IK3
1
ABL1_MOUSE
B:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
92
Blastp_CBE
38.63
45%
-49
- C4 -
-
5U6C
1
MERTK_HUMAN
A:
[23-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
N
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
M
R
L
L
G
V
C
I
E
M----IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
L
S
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
241
Blastp_CBE
38.61
41%
-65
- C4 -
-
3KFA
1
ABL1_MOUSE
A:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
97
Blastp_CBE
38.59
45%
-56
- C4 -
-
5K0X
1
MERTK_HUMAN
A:
[25-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
---
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
K
-
L
D
N
S
S
Q
--
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
-----P-
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
---------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
310
Blastp_CBE
38.55
42%
-70
- C4 -
-
3HMI
1
ABL2_HUMAN
A:
[40-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
L
---
E
P
--
P
-
F
-
Y
I
--
V
T
-
E
Y
M
P
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
E
E
------
V
-----
T
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
V
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
----
C
P
---
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
106
Blastp_CBE
38.53
45%
-56
- C4 -
-
3TCP
1
B:
[25-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
---
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
K
---------------
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
MS
S
Q
G
IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
---------------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
255
Blastp_CBE
38.52
41%
-70
- C4 -
-
6HD6
2
ABL1_MOUSE
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
-----
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
94
Blastp_CBE
38.46
45%
-72
- C4 -
-
6MEP
1
B:
[27-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
------------------
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
-----------
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
----------------------------
P
V
K
W
I
A
I
E
S
L
A
D
--
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
218
Blastp_CBE
38.40
41%
-73
- C4 -
-
3OXZ
1
ABL1_MOUSE
A:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
---------------
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
307
Blastp_CBE
38.36
42%
-65
- C4 -
-
4XLI
1
ABL2_MOUSE
A:
[16-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
--------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
L
---
E
P
--
P
-
F
-
Y
I
--
V
T
-
E
Y
M
P
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
S
R
----
E
E
------
V
-----
T
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
V
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
----
C
P
---
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
301
Blastp_CBE
38.35
41%
-70
- C4 -
-
3DK3
1
ABL1_MOUSE
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
--------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
F
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
103
Blastp_CBE
38.32
45%
-62
- C4 -
-
4MH7
1
MERTK_HUMAN
A:
[26-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
------------------
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
MS
S
Q
G
IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
----------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
306
Blastp_CBE
38.30
42%
-66
- C4 -
-
4XLI
1
B:
[12-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
L
---
E
P
--
P
-
F
-
Y
I
--
V
T
-
E
Y
M
P
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
S
R
----
E
E
------
V
-----
T
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
V
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
----
C
P
---
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
107
Blastp_CBE
38.28
45%
-57
- C4 -
-
3TCP
1
MERTK_HUMAN
A:
[26-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
-----
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
-----P-
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
----------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
99
Blastp_CBE
38.20
45%
-51
- C4 -
-
5K0K
1
MERTK_HUMAN
A:
[26-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
---
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
-----P-
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
L
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
268
Blastp_CBE
38.19
41%
-70
- C4 -
-
1OPJ
2
ABL1_MOUSE
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
257
Blastp_CBE
38.14
41%
-67
- C4 -
-
6HD4
3
ABL1_MOUSE
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
-
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
265
Blastp_CBE
38.12
41%
-66
- C4 -
-
3K5V
2
ABL1_MOUSE
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
-
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
197
Blastp_CBE
38.10
41%
-66
- C4 -
-
3OY3
1
ABL1_MOUSE
A:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
196
Blastp_CBE
38.10
41%
-65
- C4 -
-
3OY3
1
ABL1_MOUSE
B:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
272
Blastp_CBE
38.05
41%
-66
- C4 -
-
1IEP
1
ABL1_MOUSE
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
510
Blastp_CBE
38.02
38%
-65
- C4 -
-
1JPA
1
B:
[35-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
I
E
Q
V
-----
I
G
A
G
E
F
G
E
V
C
----
S
G
H
L
------------
K
---
R
E
----
I
F
V
A
I
K
T
L
K
-
S
G
-
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
-
H
P
N
V
I
H
L
E
G
V
V
T
K
--
S
------
P
V
M
I
--
I
T
-
E
F
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
Q
----------
N
D
----
G
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
----------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
--
M
T
N
-
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
----
C
P
---
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
-----------------
N
T
L
D
K
M
----------------------------------------------------
101
Blastp_CBE
37.96
45%
-54
- C4 -
-
4MHA
1
MERTK_HUMAN
A:
[29-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
---
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
K
-
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
-----P-
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
G
---------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
372
Blastp_CBE
37.89
41%
-82
- C4 -
-
5MO4
2
ABL1_HUMAN
A:
[228-477]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
--
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
---------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
269
Blastp_CBE
37.88
41%
-65
- C4 -
-
1M52
3
ABL1_MOUSE
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
98
Blastp_CBE
37.87
45%
-59
- C4 -
-
5K0K
1
B:
[26-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
--
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
-----------------
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
MS
S
Q
G
IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
----------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
316
Blastp_CBE
37.85
41%
-63
- C4 -
-
3DK6
1
ABL1_MOUSE
A:
[17-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
F
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
---------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
-
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
305
Blastp_CBE
37.84
41%
-71
- C4 -
-
3DK7
1
ABL1_MOUSE
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
--------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
-
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
235
Blastp_CBE
37.79
41%
-68
- C4 -
-
3PYY
1
ABL1_HUMAN
A:
[34-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
--------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
200
Blastp_CBE
37.79
41%
-68
- C4 -
-
2Z60
1
ABL1_MOUSE
A:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
286
Blastp_CBE
37.77
41%
-63
- C4 -
-
6BL8
1
ABL1_HUMAN
B:
[16-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
---
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
F
T
A
H
---
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
267
Blastp_CBE
37.73
41%
-65
- C4 -
-
1OPJ
2
ABL1_MOUSE
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
263
Blastp_CBE
37.72
41%
-66
- C4 -
-
3MS9
2
ABL1_MOUSE
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
-----
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
273
Blastp_CBE
37.69
41%
-67
- C4 -
-
1FPU
1
ABL1_MOUSE
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
----------
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
105
Blastp_CBE
37.68
45%
-64
- C4 -
-
4M3Q
1
MERTK_HUMAN
A:
[27-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
--------------------
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
MS
S
Q
G
IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
----------------------------
P
V
K
W
I
A
I
E
S
L
--
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
300
Blastp_CBE
37.63
41%
-71
- C4 -
-
3DK3
1
ABL1_MOUSE
B:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
--------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
F
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
270
Blastp_CBE
37.65
41%
-67
- C4 -
-
1M52
1
ABL1_MOUSE
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
256
Blastp_CBE
37.63
41%
-65
- C4 -
-
6HD4
2
ABL1_MOUSE
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
262
Blastp_CBE
37.61
41%
-66
- C4 -
-
3MS9
2
ABL1_MOUSE
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
-------
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
274
Blastp_CBE
37.60
41%
-64
- C4 -
-
1FPU
1
ABL1_MOUSE
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
222
Blastp_CBE
37.61
41%
-60
- C4 -
-
3CS9
1
ABL1_HUMAN
D:
[25-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------------------
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
271
Blastp_CBE
37.60
41%
-65
- C4 -
-
1IEP
1
ABL1_MOUSE
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
302
Blastp_CBE
37.57
41%
-65
- C4 -
-
2V7A
1
ABL1_HUMAN
B:
[22-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
-
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
511
Blastp_CBE
37.56
38%
-66
- C4 -
-
1JPA
1
EPHB2_MOUSE
A:
[35-297]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
I
E
Q
V
-----
I
G
A
G
E
F
G
E
V
C
----
S
G
H
L
--
K
----
L
--------
R
E
----
I
F
V
A
I
K
T
L
K
-
S
G
-
Y
T
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
-
H
P
N
V
I
H
L
E
G
V
V
T
K
--
S
----
T
-
P
V
M
I
--
I
T
-
E
F
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
Q
----------
N
D
----
G
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
D
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
----------------------------
P
I
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
--
M
T
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
----
C
P
---
S
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
H
R
P
K
F
G
Q
I
V
-----------------
N
T
L
D
K
M
----------------------------------------------------
266
Blastp_CBE
37.52
41%
-66
- C4 -
-
2HZN
1
ABL1_MOUSE
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
---
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
------
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
313
Blastp_CBE
37.49
42%
-62
- C4 -
-
2XYN
4
ABL2_HUMAN
B:
[40-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
------
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
L
---
E
P
--
P
-
F
-
Y
I
--
V
T
-
E
Y
M
P
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
E
E
------
V
-----
T
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
V
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
----
C
P
---
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
204
Blastp_CBE
37.48
41%
-64
- C4 -
-
2HYY
1
ABL1_HUMAN
D:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
-----
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
116
Blastp_CBE
37.49
45%
-62
- C4 -
-
5TD2
1
MERTK_HUMAN
A:
[1-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
M
-----------------
A
A
C
M
K
D
F
S
-
H
P
N
V
M
R
L
L
G
V
C
I
E
MS
S
------
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
----------------------------
P
V
K
W
I
A
I
E
S
L
----
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
195
Blastp_CBE
37.48
41%
-72
- C4 -
-
3QRJ
1
ABL1_HUMAN
A:
[26-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
---------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
----------------------------------------------------
100
Blastp_CBE
37.46
45%
-58
- C4 -
-
4MHA
1
B:
[26-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
---------------------
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
MS
S
Q
G
IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
----------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
125
Blastp_CBE
37.45
42%
-75
- C4 -
-
4CSV
1
?
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
Q
F
G
E
V
Y
----
E
G
K
W
--
R
----
N
--
Y
N
----------
I
E
V
A
V
K
T
L
K
-
E
G
-
T
M
--
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
K
---
E
P
--
P
-
I
-
Y
I
--
I
T
-
E
Y
M
S
H
G
S
L
L
D
Y
-----
L
------
R
-----------
D
C-----------------------
V
-----
N
A
Q
A
L
L
D
--------
M
A
--
A
--------
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
N
V
----
V
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
--
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
----
C
P
---
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
-----------------
H
A
L
E
T
M
F
---------------------------------------------------
225
Blastp_CBE
37.44
41%
-63
- C4 -
-
3CS9
1
ABL1_HUMAN
A:
[25-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
--------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
244
Blastp_CBE
37.43
41%
-66
- C4 -
-
2QOH
1
ABL1_MOUSE
B:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
258
Blastp_CBE
37.41
41%
-66
- C4 -
-
3MSS
2
ABL1_MOUSE
D:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
----
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
214
Blastp_CBE
37.41
41%
-62
- C4 -
-
3QRI
1
ABL1_HUMAN
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
385
Blastp_CBE
37.37
41%
-63
* C4 *
-
1OPK
3
ABL1_MOUSE
A:
[228-477]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
124
Blastp_CBE
37.39
42%
-63
- C4 -
-
4UEU
1
?
A:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
S
G
Q
F
G
E
V
Y
----
E
G
K
W
--
R
----
N
--
Y
N
----------
I
E
V
A
V
K
T
L
K
-
E
G
-
T
M
--
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
K
---
E
P
--
P
-
I
-
Y
I
--
I
T
-
E
Y
M
S
H
G
S
L
L
D
Y
-----
L
------
R
-----------
D
C---------
E
G
----
H
T
------
V
-----
N
A
Q
A
L
L
D
--------
M
A
--
A
--------
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
N
V
----
V
K
V
A
D
F
G
L
A
R
--
L
I
---------------
A
K
--
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
G
Q
V
P
Y
P
G
--
M
S
G
S
E
V
I
E
Q
V
E
R
G
Y
R
M
P
R
P
Q
G
----
C
P
---
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
-----------------
H
A
L
E
T
M
F
---------------------------------------------------
264
Blastp_CBE
37.38
41%
-65
- C4 -
-
3K5V
2
ABL1_MOUSE
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
314
Blastp_CBE
37.37
42%
-64
- C4 -
-
2XYN
2
ABL2_HUMAN
A:
[40-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
------
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
L
---
E
P
--
P
-
F
-
Y
I
--
V
T
-
E
Y
M
P
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
E
E
------
V
-----
T
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
V
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
----
C
P
---
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
259
Blastp_CBE
37.36
41%
-67
- C4 -
-
3MSS
2
ABL1_MOUSE
C:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
----
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
260
Blastp_CBE
37.30
41%
-67
- C4 -
-
3MSS
2
ABL1_MOUSE
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
----
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
205
Blastp_CBE
37.28
41%
-72
- C4 -
-
2HYY
1
ABL1_HUMAN
C:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
----
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
------
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
194
Blastp_CBE
37.27
41%
-62
- C4 -
-
3QRJ
1
ABL1_HUMAN
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
303
Blastp_CBE
37.24
41%
-58
- C4 -
-
2V7A
1
ABL1_HUMAN
A:
[22-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
-
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
318
Blastp_CBE
37.21
41%
-64
- C4 -
-
2GQG
2
ABL1_HUMAN
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
-
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
96
Blastp_CBE
37.21
45%
-61
- C4 -
-
5K0X
1
B:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
--
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
-------------
E
F
L
S
E
A
A
C
M
K
D
F
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
MS
S
Q
G
IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
-----------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
245
Blastp_CBE
37.19
41%
-63
- C4 -
-
2QOH
1
ABL1_MOUSE
A:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
117
Blastp_CBE
37.17
44%
-38
- C4 -
-
5U6B
1
D:
[6-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
E
L
K
E
K
L
R
D
V
M
V
D
R
H
K
-------------------------
V
A
L
G
K
T
-----
L
G
E
G
E
F
G
A
V
M
----
E
G
Q
L
-------
N
--
Q
-----
S
I
----
L
K
V
A
V
K
T
M
K
I
A
I
-
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
-
H
P
N
V
M
R
L
I
G
V
C
F
-RE
S
F
P
--
A
-
P
-
V
V
--
I
L
-
P
F
M
K
H
G
D
L
H
S
F
-----
L
LYSRLG
D
-----------
Q
----------
P
V
----
Y
L
------
P
-----
T
-
Q
M
L
V
K
--------
F
M
--
A
--------
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
--
M
S
----
V
C
V
A
D
F
G
L
S
K
--
K
I
Y
--
N
G
D
Y
Y
-----
R
I
A
K
--
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
--
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
----
C
L
---
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
----------------------------------------------------------------------------
254
Blastp_CBE
37.15
41%
-66
- C4 -
-
6HD6
1
ABL1_MOUSE
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
120
Blastp_CBE
37.12
44%
-52
- C4 -
-
5U6B
1
UFO_HUMAN
A:
[10-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
K
L
R
D
V
M
V
D
R
H
K
-------------------------
V
A
L
G
K
T
-----
L
G
E
G
E
F
G
A
V
M
----
E
G
Q
L
-------
N
--
Q
D
D
---
S
I
----
L
K
V
A
V
K
T
M
K
I
A
I
-
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
-
H
P
N
V
M
R
L
I
G
V
C
F
Q
----
P
--
A
-
P
-
V
V
--
I
L
-
P
F
M
K
H
G
D
L
H
S
F
-----
L
LYSRLG
D
-----------
Q
----------
P
V
----
Y
L
------
P
-----
T
-
Q
M
L
V
K
--------
F
M
--
A
--------
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
--
M
S
----
V
C
V
A
D
F
G
L
S
K
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
--
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
----
C
L
---
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
----------------------------------------------------------------------------
312
Blastp_CBE
37.08
42%
-62
- C4 -
-
2XYN
4
ABL2_HUMAN
C:
[40-289]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
V
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
------
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
L
---
E
P
--
P
-
F
-
Y
I
--
V
T
-
E
Y
M
P
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
E
E
------
V
-----
T
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
V
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
D
L
L
E
K
G
Y
R
M
E
Q
P
E
G
----
C
P
---
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
287
Blastp_CBE
37.08
41%
-60
- C4 -
-
6BL8
1
ABL1_HUMAN
A:
[16-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
F
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
247
Blastp_CBE
37.08
41%
-70
- C4 -
-
4YC8
3
ABL1_HUMAN
A:
[17-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
--------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
252
Blastp_CBE
37.06
41%
-59
- C4 -
-
2G1T
1
ABL1_HUMAN
B:
[23-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
217
Blastp_CBE
37.06
41%
-69
- C4 -
-
5HU9
12
ABL1_HUMAN
A:
[25-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
--------------
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
261
Blastp_CBE
36.98
41%
-64
- C4 -
-
3MSS
2
ABL1_MOUSE
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
----
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
207
Blastp_CBE
36.99
41%
-64
- C4 -
-
2HYY
1
ABL1_HUMAN
A:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-----
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
221
Blastp_CBE
36.98
41%
-70
- C4 -
-
2E2B
1
ABL1_HUMAN
A:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
--------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
-------
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
420
Blastp_CBE
36.97
41%
-60
- C4 -
-
2FO0
3
ABL1_HUMAN
A:
[225-474]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
119
Blastp_CBE
36.96
44%
-36
- C4 -
-
5U6B
1
UFO_HUMAN
B:
[6-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
S
E
E
L
K
E
K
L
R
D
V
M
V
D
R
H
K
-------------------------
V
A
L
G
K
T
-----
L
G
E
G
E
F
G
A
V
M
----
E
G
Q
L
-------
N
--
Q
-----
S
I
----
L
K
V
A
V
K
T
M
K
I
A
I
-
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
-
H
P
N
V
M
R
L
I
G
V
C
F
-RE
S
F
P
--
A
-
P
-
V
V
--
I
L
-
P
F
M
K
H
G
D
L
H
S
F
-----
L
LYSRLG
D
-----------
Q
----------
P
V
----
Y
L
------
P
-----
T
-
Q
M
L
V
K
--------
F
M
--
A
--------
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
--
M
S
----
V
C
V
A
D
F
G
L
S
K
--
K
I
Y
--
N
G
D
Y
Y
-----
R
I
A
K
--
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
--
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
----
C
L
---
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
----------------------------------------------------------------------------
304
Blastp_CBE
36.93
41%
-67
- C4 -
-
3DK7
1
ABL1_MOUSE
B:
[19-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
--------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
-
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
375
Blastp_CBE
36.91
39%
-69
- C4 -
-
3DKO
1
A:
[45-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
K
I
E
R
V
-----
I
G
A
-
E
F
G
E
V
C
----
S
G
R
L
--
K
----
L
--
P
G
K
---
R
D
----
V
A
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
C
E
A
S
I
M
G
Q
F
D
-
H
P
N
V
V
H
L
E
G
V
V
T
R
----
G
--
K
-
P
V
M
I
--
V
I
-
E
F
M
E
N
G
A
L
D
A
F
-----
L
------
R
-----------
K
----------
H
D
----
G
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
---------------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
Y
G
E
R
P
Y
W
D
--
M
S
N
Q
D
V
I
K
A
I
E
E
G
Y
R
L
P
A
P
M
D
----
C
P
---
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
E
Q
I
V
-----------------
G
---------------------------------------------------------
213
Blastp_CBE
36.94
41%
-68
- C4 -
-
3QRI
1
ABL1_HUMAN
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
---------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
246
Blastp_CBE
36.93
41%
-66
- C4 -
-
4YC8
3
ABL1_HUMAN
B:
[17-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
118
Blastp_CBE
36.91
44%
-52
- C4 -
-
5U6B
1
UFO_HUMAN
C:
[10-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
K
L
R
D
V
M
V
D
R
H
K
-------------------------
V
A
L
G
K
T
-----
L
G
E
G
E
F
G
A
V
M
----
E
G
Q
L
-------
N
--
Q
D
D
---
S
I
----
L
K
V
A
V
K
T
M
K
I
A
I
-
C
T
R
S
E
L
E
D
F
L
S
E
A
V
C
M
K
E
F
D
-
H
P
N
V
M
R
L
I
G
V
C
F
Q
----
P
--
A
-
P
-
V
V
--
I
L
-
P
F
M
K
H
G
D
L
H
S
F
-----
L
LYSRLG
D
-----------
Q
----------
P
V
----
Y
L
------
P
-----
T
-
Q
M
L
V
K
--------
F
M
--
A
--------
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
E
N
--
M
S
----
V
C
V
A
D
F
G
L
S
K
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
G
Q
T
P
Y
P
G
--
V
E
N
S
E
I
Y
D
Y
L
R
Q
G
N
R
L
K
Q
P
A
D
----
C
L
---
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
L
----------------------------------------------------------------------------
212
Blastp_CBE
36.89
41%
-62
- C4 -
-
3QRK
1
ABL1_HUMAN
A:
[26-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
----------------------------------------------------
206
Blastp_CBE
36.84
41%
-65
- C4 -
-
2HYY
1
ABL1_HUMAN
B:
[21-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
----
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
538
Blastp_CBE
36.82
41%
-64
- C4 -
-
1OPL
1
ABL1_HUMAN
B:
[267-516]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
291
Blastp_CBE
36.81
41%
-57
- C4 -
-
2G2H
1
ABL1_HUMAN
A:
[23-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
T
A
---
P
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
230
Blastp_CBE
36.75
41%
-72
- C4 -
-
6NPU
5
ABL1_HUMAN
B:
[34-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
----------------------
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
290
Blastp_CBE
36.73
41%
-62
- C4 -
-
2G2H
1
ABL1_HUMAN
B:
[23-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
T
A
---
P
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
233
Blastp_CBE
36.69
41%
-68
- C4 -
-
6NPE
2
ABL1_HUMAN
A:
[34-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
227
Blastp_CBE
36.68
41%
-61
- C4 -
-
2HZI
1
ABL1_HUMAN
A:
[25-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
238
Blastp_CBE
36.65
41%
-67
- C4 -
-
2HIW
1
ABL1_HUMAN
B:
[23-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
229
Blastp_CBE
36.64
41%
-68
- C4 -
-
6NPV
2
ABL1_HUMAN
A:
[34-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
248
Blastp_CBE
36.63
41%
-58
- C4 -
-
3UE4
1
ABL1_HUMAN
B:
[23-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
--
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
122
Blastp_CBE
36.60
41%
-75
- C4 -
-
4FEQ
1
A:
[22-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
F
-------------------
T
----
L
--
G
R
M
-----
L
G
K
---
G
S
V
R
----
E
A
Q
L
--
K
--------
D
G
---
S
F
----
V
K
V
A
V
K
M
L
-------------
F
L
R
E
A
A
C
M
K
E
F
D
-
H
P
H
V
A
K
L
V
G
V
S
-----------
P
-
M
V
--
I
L
-
P
F
M
K
H
G
D
L
H
A
F
LLASR
I
-------------------------------------------------
P
L
Q
T
L
V
R
--------
F
M
--
V
--------
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
--
M
T
----
V
C
V
A
D
F
G
----------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
--
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
----
C
M
---
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
-----------------
M
E
L
E
N
I
L
G
--------------------------------------------------
317
Blastp_CBE
36.59
41%
-59
- C4 -
-
2GQG
2
ABL1_HUMAN
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
-
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
242
Blastp_CBE
36.57
41%
-60
- C4 -
-
3KF4
1
ABL1_MOUSE
B:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
-------
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
539
Blastp_CBE
36.55
41%
-63
- C4 -
-
1OPL
2
ABL1_HUMAN
A:
[267-516]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
220
Blastp_CBE
36.53
41%
-71
- C4 -
-
2E2B
1
ABL1_HUMAN
B:
[26-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
---------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
-----------
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
239
Blastp_CBE
36.51
41%
-60
- C4 -
-
2HIW
1
ABL1_HUMAN
A:
[23-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
381
Blastp_CBE
36.46
42%
-72
- C4 -
-
3RCD
1
ERBB2_HUMAN
C:
[23-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-----
L
G
S
G
A
F
G
T
V
Y
----
K
G
I
W
--
I
P---
D
--
G
E
N
---
V
K
----
I
P
V
A
I
K
V
L
R
------
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
-
S
P
Y
V
S
R
L
L
G
I
C
L
T
--
S
----
T
-
V
-
Q
L
--
V
T
-
Q
L
M
P
Y
G
C
L
L
D
H
-----
V
------
R
-----------
E
----------
N
R
----
G
R
------
L
-----
G
S
Q
D
L
L
N
--------
W
C
--
M
--------
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
--
N
H
----
V
K
I
T
D
F
G
L
-------------------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
--
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
----
C
T
---
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
-----------------
S
E
F
S
R
M
----------------------------------------------------
228
Blastp_CBE
36.45
41%
-69
- C4 -
-
6NPV
5
ABL1_HUMAN
B:
[34-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
----------------------
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
201
Blastp_CBE
36.44
41%
-55
- C4 -
-
2HZ4
2
ABL1_HUMAN
C:
[16-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
------
T
V
A
V
K
T
L
K
-----
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
243
Blastp_CBE
36.43
41%
-64
- C4 -
-
3KF4
1
ABL1_MOUSE
A:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
234
Blastp_CBE
36.32
41%
-66
- C4 -
-
3PYY
3
ABL1_HUMAN
B:
[34-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
----------------------
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
224
Blastp_CBE
36.30
41%
-72
- C4 -
-
3CS9
1
ABL1_HUMAN
B:
[25-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
-------
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
384
Blastp_CBE
36.24
42%
-41
- C4 -
-
3PP0
1
ERBB2_HUMAN
A:
[23-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-----
L
G
S
G
A
F
G
T
V
Y
----
K
G
I
W
--
I
P---
D
--
G
E
N
---
V
K
----
I
P
V
A
I
K
V
L
R
-
E
N
-
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
-
S
P
Y
V
S
R
L
L
G
I
C
L
T
--
S
----
T
-
V
-
Q
L
--
V
T
-
Q
L
M
P
Y
G
C
L
L
D
H
-----
V
------
R
-----------
E
----------
N
R
----
G
R
------
L
-----
G
S
Q
D
L
L
N
--------
W
C
--
M
--------
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
--
N
H
----
V
K
I
T
D
F
G
L
A
R
LL
D
I
D
--
E
T
E
Y
H
A
------
G
K
--
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
--
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
----
C
T
---
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
-----------------
S
E
F
S
R
M
----------------------------------------------------
285
Blastp_CBE
36.25
41%
-53
- C4 -
-
2F4J
1
ABL1_HUMAN
A:
[22-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
T
A
---
P
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
215
Blastp_CBE
36.25
41%
-78
- C4 -
-
2HZ0
1
ABL1_HUMAN
B:
[15-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
--------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
--------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
293
Blastp_CBE
36.24
41%
-56
- C4 -
-
2G2F
1
ABL1_HUMAN
A:
[23-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
T
A
---
P
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
382
Blastp_CBE
36.19
42%
-72
- C4 -
-
3RCD
1
ERBB2_HUMAN
A:
[23-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-----
L
G
S
G
A
F
G
T
V
Y
----
K
G
I
W
--
I
P---
D
--
G
E
N
---
V
K
----
I
P
V
A
I
K
V
L
R
------
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
-
S
P
Y
V
S
R
L
L
G
I
C
L
T
--
S
----
T
-
V
-
Q
L
--
V
T
-
Q
L
M
P
Y
G
C
L
L
D
H
-----
V
------
R
-----------
E
----------
N
R
----
G
R
------
L
-----
G
S
Q
D
L
L
N
--------
W
C
--
M
--------
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
--
N
H
----
V
K
I
T
D
F
G
L
-------------------------
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
--
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
----
C
T
---
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
-----------------
S
E
F
S
R
M
----------------------------------------------------
250
Blastp_CBE
36.22
41%
-59
- C4 -
-
2G1T
1
ABL1_HUMAN
D:
[23-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
253
Blastp_CBE
36.19
41%
-58
- C4 -
-
2G1T
1
ABL1_HUMAN
A:
[23-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
232
Blastp_CBE
36.18
41%
-76
- C4 -
-
6NPE
3
ABL1_HUMAN
B:
[34-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
----------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
--------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
202
Blastp_CBE
36.17
41%
-60
- C4 -
-
2HZ4
1
ABL1_HUMAN
B:
[16-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
93
Blastp_CBE
36.15
45%
-62
- C4 -
-
5TC0
1
MERTK_HUMAN
A:
[28-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
V
I
D
R
N
L
L
-------------------
I
----
L
--
G
K
I
-----
L
G
E
G
E
F
G
S
V
M
----
E
G
N
L
--
K
----
Q
--
E
D
G
---
T
S
----
L
K
V
A
V
K
T
---------------------
M
K
D
F
S
-
H
P
N
V
M
R
L
L
G
V
C
I
E
MS
S
Q
G
IP
K
-
P
-
M
V
--
I
L
-
P
F
M
K
Y
G
D
L
H
T
Y
-----
L
LYS---
R
-----------
L
----------
E
T
GPK-
H
I
------
P
------
L
Q
T
L
L
K
--------
F
M
--
V
--------
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
D
D
--
M
T
----
V
C
V
A
D
F
---------------------------
M
P
V
K
W
I
A
I
E
-------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
G
M
T
P
Y
P
G
--
V
Q
N
H
E
M
Y
D
Y
L
L
H
G
H
R
L
K
Q
P
E
D
----
C
L
---
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
-----------------
L
Q
L
E
K
L
L
E
S
L
------------------------------------------------
231
Blastp_CBE
36.10
41%
-66
- C4 -
-
6NPU
2
ABL1_HUMAN
A:
[34-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
210
Blastp_CBE
36.10
41%
-58
- C4 -
-
4WA9
1
ABL1_HUMAN
B:
[22-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
383
Blastp_CBE
36.07
42%
-45
- C4 -
-
3PP0
1
B:
[23-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-----
L
G
S
G
A
F
G
T
V
Y
----
K
G
I
W
--
I
P---
D
--
G
E
N
---
V
K
----
I
P
V
A
I
K
V
L
R
-
E
N
-
T
S
P
K
A
N
K
E
I
L
D
E
A
Y
V
M
A
G
V
G
-
S
P
Y
V
S
R
L
L
G
I
C
L
T
--
S
----
T
-
V
-
Q
L
--
V
T
-
Q
L
M
P
Y
G
C
L
L
D
H
-----
V
------
R
-----------
E
----------
N
R
----
G
R
------
L
-----
G
S
Q
D
L
L
N
--------
W
C
--
M
--------
Q
I
A
K
G
M
S
Y
L
E
D
V
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
--
N
H
----
V
K
I
T
D
F
G
L
A
R
LL
D
I
D
--
E
T
E
Y
H
A
------
G
K
--
V
P
I
K
W
M
A
L
E
S
I
L
R
R
R
F
T
H
Q
S
D
V
W
S
Y
G
V
T
V
W
E
L
M
T
F
G
A
K
P
Y
D
G
--
I
P
A
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
----
C
T
---
I
D
V
Y
M
I
M
V
K
C
W
M
I
D
S
E
C
R
P
R
F
R
E
L
V
-----------------
S
E
F
S
R
M
----------------------------------------------------
251
Blastp_CBE
36.02
41%
-57
- C4 -
-
2G1T
1
ABL1_HUMAN
C:
[23-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
209
Blastp_CBE
35.98
41%
-58
- C4 -
-
4ZOG
5
ABL1_HUMAN
A:
[20-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
292
Blastp_CBE
35.97
41%
-55
- C4 -
-
2G2F
1
ABL1_HUMAN
B:
[18-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
T
A
---
P
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
309
Blastp_CBE
35.95
41%
-54
- C4 -
-
4XEY
1
ABL1_HUMAN
A:
[129-382]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
193
Blastp_CBE
35.93
41%
-63
- C4 -
-
4TWP
1
ABL1_HUMAN
A:
[16-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
---------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
226
Blastp_CBE
35.92
41%
-64
- C4 -
-
2HZI
1
ABL1_HUMAN
B:
[25-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
--------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
203
Blastp_CBE
35.79
41%
-57
- C4 -
-
2HZ4
2
ABL1_HUMAN
A:
[16-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
223
Blastp_CBE
35.75
41%
-75
- C4 -
-
3CS9
1
ABL1_HUMAN
C:
[25-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
---------
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
---------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
192
Blastp_CBE
35.73
41%
-57
- C4 -
-
4TWP
1
ABL1_HUMAN
B:
[16-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
I
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
553
Fugue
35.68
39%
-34
- C4 -
-
1BYG
1
CSK_HUMAN
A:
[15-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
W
A
L
N
M
K
-------------------
E
----
L
K
L
L
Q
T
-----
I
G
K
G
E
F
G
D
V
M
----
L
G
D
Y
RG--------------------
N
K
V
A
V
K
C
I
K
-------
N
D
A
Q
A
F
L
A
E
A
S
V
M
T
Q
L
R
-
H
S
N
L
V
Q
L
L
G
V
I
V
----
E
E
--
G
-
L
-
Y
I
--
V
T
-
E
Y
M
A
K
G
S
L
V
D
Y
-----
L
------
R
-----------
S
RG---------
R
----
S
V
------
L
-----
G
G
D
C
L
L
K
--------
F
S
--
L
--------
D
V
C
E
A
M
E
Y
L
E
G
N
N
F
V
H
R
D
L
A
A
R
N
V
L
V
S
E
D
--
N
V
----
A
K
V
S
D
F
G
-----------------------
L
--
L
P
V
K
W
T
A
P
E
A
L
R
E
K
K
F
S
T
K
S
D
V
W
S
F
G
I
L
L
W
E
I
Y
S
F
G
R
V
P
Y
P
R
--
I
P
L
K
D
V
V
P
R
V
E
K
G
Y
K
M
D
A
P
D
G
----
C
P
---
P
A
V
Y
E
V
M
K
N
C
W
H
L
D
A
A
M
R
P
S
F
L
Q
L
R
-----------------
E
Q
L
E
H
I
K
T
H
E
L
-----------------------------------------------
249
Blastp_CBE
35.66
41%
-52
- C4 -
-
3UE4
1
ABL1_HUMAN
A:
[23-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
Q
--------------------------------------------------
288
Blastp_CBE
35.47
41%
-56
- C4 -
-
2G2I
1
ABL1_HUMAN
B:
[19-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
T
A
---
P
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
208
Blastp_CBE
35.13
41%
-56
- C4 -
-
4ZOG
2
ABL1_HUMAN
B:
[20-269]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
----
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
299
Blastp_CBE
35.08
42%
-44
- C4 -
-
3BBT
1
ERBB4_HUMAN
B:
[21-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-----
L
G
S
G
A
F
G
T
V
Y
----
K
G
I
W
--
V
P---
E
--
G
E
T
---
V
K
----
I
P
V
A
I
K
I
L
N
-
E
---
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
-
H
P
H
L
V
R
L
L
G
V
C
L
--------
S
-
P
-
T
I
QL
V
T
-
Q
L
M
P
H
G
C
L
L
E
Y
-----
V
------
H
-----------
E
----------
H
K
----
D
N
------
I
-----
G
S
Q
L
L
L
N
--------
W
C
--
V
--------
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
--
N
H
----
V
K
I
T
D
F
G
L
A
R
--
L
L
--------------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
--
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
----
C
T
---
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
-----------------
A
E
F
S
R
M
----------------------------------------------------
216
Blastp_CBE
34.90
41%
-45
- C4 -
-
2HZ0
1
ABL1_HUMAN
A:
[21-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
289
Blastp_CBE
34.74
41%
-45
- C4 -
-
2G2I
1
ABL1_HUMAN
A:
[23-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
---
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
Y
T
A
---
P
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
145
Blastp_CBE
34.73
40%
-20
- C4 -
-
3LVP
2
IGF1R_HUMAN
A:
[39-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
W
-------------------
E
----
V
A
R
E
K
I
TMSRE
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
----
E
-PVLAP-
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
-------------
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
138
Blastp_CBE
34.73
42%
-10
- C4 -
-
3QQU
1
IGF1R_HUMAN
C:
[20-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
------VLAP--
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
298
Blastp_CBE
34.56
42%
-37
- C4 -
-
3BBT
1
D:
[21-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-----
L
G
S
G
A
F
G
T
V
Y
----
K
G
I
W
--
V
P-------
E
T
---
V
K
----
I
P
V
A
I
K
I
L
N
-
E
----
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
-
H
P
H
L
V
R
L
L
G
V
C
L
--------
S
-
P
-
T
I
QL
V
T
-
Q
L
M
P
H
G
C
L
L
E
Y
-----
V
------
H
-----------
E
----------
H
K
----
D
N
------
I
-----
G
S
Q
L
L
L
N
--------
W
C
--
V
--------
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
--
N
H
----
V
K
I
T
D
F
G
L
A
R
------------------------
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
--
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
----
C
T
---
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
-----------------
A
E
F
S
R
M
----------------------------------------------------
296
Blastp_CBE
34.56
42%
-31
- C4 -
-
3BCE
2
C:
[21-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-----
L
G
S
G
A
F
G
T
V
Y
----
K
G
I
W
--
V
P---
E
--
G
E
T
---
V
K
----
I
P
V
A
I
K
I
L
N
-
E
T
-
T
G
P
K
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
-
H
P
H
L
V
R
L
L
G
V
C
L
--------
S
-
P
-
T
I
QL
V
T
-
Q
L
M
P
H
G
C
L
L
E
Y
-----
V
------
H
-----------
E
----------
H
K
----
D
N
------
I
-----
G
S
Q
L
L
L
N
--------
W
C
--
V
--------
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
--
N
H
----
V
K
I
T
D
F
G
L
A
R
--
L
L
E
D-
E
K
E
Y
----
N
A
D
-
G
K
--
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
--
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
----
C
T
---
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
-----------------
A
E
F
S
R
M
----------------------------------------------------
170
Blastp_CBE
34.56
42%
-13
- C4 -
-
3D94
1
A:
[20-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LR----------------------
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
130
Blastp_CBE
34.55
42%
-3
- C4 -
-
3NW5
1
A:
[26-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
----
E
N
NPVLAP
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
141
Blastp_CBE
34.33
42%
-8
- C4 -
-
5FXR
1
A:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
--
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
----
E
N
NPVLAP
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
---
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
133
Blastp_CBE
34.32
42%
-25
- C4 -
-
1JQH
1
IGF1R_HUMAN
B:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP---------------P-----
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
-----------
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
554
Fugue
34.29
35%
8
- C4 -
-
3CD3
3
A:
[1-376]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
WYH
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
GDFL
V
R
E
S
Q
E
Y
V
L
S
V
P
---
R
H
F
I
I
N
L
Y
R
L
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
SGVVLHRAVPKDKWVLNHE
D
----
L
V
L
G
E
Q
-----
I
G
R
G
N
F
G
E
V
F
----
S
G
R
L
--
R
----
A
--
D
N
T
----------
L
V
A
V
K
S
C
R
-
P
-----
D
L
K
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
S
-
H
P
N
I
V
R
L
I
G
V
C
-
T
--
Q
K
Q
--
P
-
I
-
Y
I
--
V
M
-
E
L
V
Q
G
G
D
F
L
T
F
-----
L
------
R
-----------
T
----------
E
G
----
A
R
------
L
-----
R
V
K
T
L
L
Q
--------
M
V
--
G
--------
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
--
N
V
----
L
K
I
S
D
F
G
M
S
R
--
E
E
A
--
D
G
V
A
A
S
---
G
G
L
R
Q
--
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
G
A
S
P
Y
P
N
--
L
S
N
Q
Q
T
R
E
F
V
E
K
G
G
R
L
P
C
P
E
L
----
C
P
---
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
-----------------
Q
E
L
Q
S
I
R
K
R
H
------------------------------------------------
426
Blastp_CBE
34.16
40%
-11
- C4 -
-
4ZSA
1
FGFR1_HUMAN
A:
[27-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
379
Blastp_CBE
34.10
39%
-20
- C4 -
-
3ZBF
1
A:
[40-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
L
G
S
G
---
E
V
Y
----
E
G
T
A
--
V
----
D
--
I
L
G
VGS
G
E
----
I
K
V
A
V
K
T
L
K
-
K
G
-
S
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
L
--
N
E
---
P
-
Q
-
Y
I
--
I
L
-
E
L
M
E
G
G
D
L
L
T
Y
-----
L
------
R
-----------
K
----------
A
R
MATF
Y
G
------
P
-----
L
L
T
L
V
D
L
--------
V
D
LC
V
--------
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D-
Y
T
SPRI
V
K
I
G
D
F
G
L
A
R
--
D
I
Y
------------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
--
H
S
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
----
C
P
---
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
-----------------
D
Q
L
Q
L
F
R
N
F
F
L
N
--
S
I
Y
-----------------------------------------
457
Blastp_CBE
34.04
40%
-27
- C4 -
-
6C19
1
FGFR1_HUMAN
A:
[26-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPEYSY--
N
----------
P
S
-------------EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
283
Blastp_CBE
34.06
42%
-31
- C4 -
-
2R4B
1
B:
[44-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-----
L
G
S
G
A
F
G
T
V
Y
----
K
G
I
W
--
V
P---
E
--
G
E
T
---
V
K
----
I
P
V
A
I
K
I
L
---------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
-
H
P
H
L
V
R
L
L
G
V
C
L
--------
S
-
P
-
T
I
QL
V
T
-
Q
L
M
P
H
G
C
L
L
E
Y
-----
V
------
H
-----------
E
----------
H
K
----
D
N
------
I
-----
G
S
Q
L
L
L
N
--------
W
C
--
V
--------
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
--
N
H
----
V
K
I
T
D
F
G
L
A
R
--
L
L
E
GD
E
K
E
Y
----
N
A
D
G
G
K
--
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
--
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
----
C
T
---
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
-----------------
A
E
F
S
R
M
----------------------------------------------------
135
Blastp_CBE
34.04
42%
-2
- C4 -
-
4D2R
1
A:
[21-282]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
----
E
N
NPVLAP
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
--
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
129
Blastp_CBE
34.04
42%
-6
- C4 -
-
3NW6
1
A:
[26-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
----
E
N
NPVLAP
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
128
Blastp_CBE
34.01
42%
-4
- C4 -
-
3NW7
1
A:
[26-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
----
E
N
NPVLAP
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
---
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
147
Blastp_CBE
34.00
42%
-2
- C4 -
-
5HZN
3
H:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRPA------
M
A
----
N
N
------
P
VLAPP
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
479
Blastp_CBE
33.98
40%
-1
- C4 -
-
4UWC
9
FGFR1_HUMAN
A:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY-----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
445
Blastp_CBE
33.97
40%
-14
- C4 -
-
1FGI
1
FGFR1_HUMAN
A:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
151
Blastp_CBE
33.91
42%
-1
- C4 -
-
5HZN
3
IGF1R_HUMAN
D:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRPA------
M
A
----
N
N
------
P
VLAPP
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
284
Blastp_CBE
33.89
42%
-27
- C4 -
-
2R4B
1
ERBB4_HUMAN
A:
[44-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
-----
L
G
S
G
A
F
G
T
V
Y
----
K
G
I
W
--
V
P---
E
--
G
E
T
---
V
K
----
I
P
V
A
I
K
I
L
N
--------
A
N
V
E
F
M
D
E
A
L
I
M
A
S
M
D
-
H
P
H
L
V
R
L
L
G
V
C
L
--------
S
-
P
-
T
I
QL
V
T
-
Q
L
M
P
H
G
C
L
L
E
Y
-----
V
------
H
-----------
E
----------
H
K
----
D
N
------
I
-----
G
S
Q
L
L
L
N
--------
W
C
--
V
--------
Q
I
A
K
G
M
M
Y
L
E
E
R
R
L
V
H
R
D
L
A
A
R
N
V
L
V
K
S
P
--
N
H
----
V
K
I
T
D
F
G
L
A
R
--
L
L
E
GD
E
K
E
Y
----
N
A
D
G
G
K
--
M
P
I
K
W
M
A
L
E
C
I
H
Y
R
K
F
T
H
Q
S
D
V
W
S
Y
G
V
T
I
W
E
L
M
T
F
G
G
K
P
Y
D
G
--
I
P
T
R
E
I
P
D
L
L
E
K
G
E
R
L
P
Q
P
P
I
----
C
T
---
I
D
V
Y
M
V
M
V
K
C
W
M
I
D
A
D
S
R
P
K
F
K
E
L
A
-----------------
A
E
F
S
R
M
----------------------------------------------------
140
Blastp_CBE
33.88
42%
-9
- C4 -
-
3QQU
1
IGF1R_HUMAN
A:
[20-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LR----------------P-----
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
131
Blastp_CBE
33.88
42%
-2
- C4 -
-
2OJ9
1
A:
[26-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
-------P-----
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
159
Blastp_CBE
33.81
42%
0
- C4 -
-
5FXS
1
A:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
----
E
N
NPVLAP
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
A
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
E
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
503
Blastp_CBE
33.75
40%
-4
- C4 -
-
4RWJ
1
FGFR1_HUMAN
A:
[36-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
-
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
427
Blastp_CBE
33.74
40%
-8
- C4 -
-
3C4F
1
B:
[21-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
498
Blastp_CBE
33.72
38%
-30
- C4 -
-
4PMP
1
A:
[16-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
L
-----------------
K
----
M
L
V
A
V
K
A
L
K
------
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
-----
D
A
K
L
L
A
G
GEDVAPGP
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
M
S
R
---
I
Y
--
S
T
D
Y
Y
R
V
G
--
T
--
M
--
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
378
Blastp_CBE
33.65
39%
-10
- C4 -
-
4UXL
1
A:
[40-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
-----
L
G
S
G
A
F
G
E
V
Y
----
E
G
T
A
--
V
----
D
--
I
L
G
VGS
G
E
----
I
K
V
A
V
K
T
L
K
-
K
G
-
S
T
D
Q
E
K
I
E
F
L
K
E
A
H
L
M
S
K
F
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
L
--
N
E
---
P
-
Q
-
Y
I
--
I
L
-
E
L
M
E
G
G
D
L
L
T
Y
-----
L
------
R
-----------
K
----------
A
R
MATF
Y
G
------
P
-----
L
L
T
L
V
D
L
--------
V
D
LC
V
--------
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D-
Y
T
SPRI
V
K
I
G
D
F
G
L
A
R
--
D
I
Y
--
K
----------
E
G
L
--
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
G
H
Q
P
Y
P
A
--
H
S
N
L
D
V
L
N
Y
V
Q
T
G
G
R
L
E
P
P
R
N
----
C
P
---
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
-----------------
D
Q
L
Q
L
F
R
N
F
F
L
N
--
S
I
Y
-----------------------------------------
421
Blastp_CBE
33.63
40%
-16
- C4 -
-
6ITJ
1
?
B:
[27-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY-------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
---------
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
139
Blastp_CBE
33.62
42%
-11
- C4 -
-
3QQU
1
IGF1R_HUMAN
B:
[20-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LR----------------------
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
148
Blastp_CBE
33.60
42%
-5
- C4 -
-
5HZN
4
IGF1R_HUMAN
G:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP----------------------APP--
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
430
Blastp_CBE
33.59
40%
0
- C4 -
-
4RWK
1
FGFR1_HUMAN
A:
[36-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
M
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
134
Blastp_CBE
33.57
42%
-8
- C4 -
-
1JQH
1
IGF1R_HUMAN
A:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
-------VLAP--
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
-----------
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
557
Fugue
33.56
19%
-34
- C4 -
-
1KOB
1
?
A:
[23-374]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
K
Q
G
S
V
Y
D
-------------------
Y
----
Y
D
I
L
E
E
-----
L
G
S
G
A
F
G
V
V
H
----
R
C
V
E
--
K
----
A
--
T
G
R
----------
V
F
V
A
K
F
I
N
-
T
--
P
Y
P
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
-
H
P
K
L
I
N
-
L
H
D
A
F
E
--
D
K
Y
--
E
-
M
-
V
L
--
I
L
-
E
F
L
S
G
G
E
L
F
D
R
-----
I
------
A
-----------
A
----------
E
D
----
Y
K
------
M
-----
S
E
A
E
V
I
N
--------
Y
M
--
R
--------
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
KA
S
S
----
V
K
I
I
D
F
G
L
A
T
--
K
L
N
--
P
D
E
I
V
K
V
T
T
A
T
-------
A
E
F
A
A
P
E
I
V
D
R
E
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
-
G
L
S
P
F
A
G
--
E
D
D
L
E
T
L
Q
N
V
K
R
C
D
W
E
F
D
E
D
A
----
F
S
SVS
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
EHPWLKGDHSNLTSRIP
S
S
R
Y
N
K
I
R
Q
K
I
K
--
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
-
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-
144
Blastp_CBE
33.55
40%
6
- C4 -
-
3LVP
1
IGF1R_HUMAN
B:
[36-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
--
P
D
E
W
-------------------
E
----
V
A
R
E
K
I
TMSRE
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
-------VLAP--
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
----
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
428
Blastp_CBE
33.53
40%
-7
- C4 -
-
3C4F
1
FGFR1_HUMAN
A:
[21-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
152
Blastp_CBE
33.51
42%
-4
- C4 -
-
5HZN
3
IGF1R_HUMAN
C:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP----------------------APP--
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
424
Blastp_CBE
33.46
40%
-8
- C4 -
-
5Z0S
1
FGFR1_HUMAN
A:
[27-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
493
Blastp_CBE
33.33
40%
-9
- C4 -
-
4F63
3
FGFR1_HUMAN
A:
[24-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
-
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
447
Blastp_CBE
33.34
40%
-10
- C4 -
-
1AGW
1
FGFR1_HUMAN
A:
[25-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
-
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
143
Blastp_CBE
33.33
40%
6
- C4 -
-
3LVP
1
IGF1R_HUMAN
C:
[37-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
--
P
D
E
W
-------------------
E
----
V
A
R
E
K
I
TMSRE
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
-------VLAP--
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
----
R
K
--
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
423
Blastp_CBE
33.29
40%
-12
- C4 -
-
5Z0S
1
B:
[27-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
-
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
149
Blastp_CBE
33.28
42%
-2
- C4 -
-
5HZN
3
IGF1R_HUMAN
F:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP----------------------APP--
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
469
Blastp_CBE
33.27
40%
-9
- C4 -
-
5O49
1
FGFR1_HUMAN
A:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
422
Blastp_CBE
33.24
40%
-6
- C4 -
-
6ITJ
1
?
A:
[27-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
162
Blastp_CBE
33.20
42%
4
- C4 -
-
3ETA
1
INSR_HUMAN
A:
[24-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
-
G
K
--
G
L
--
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
167
Blastp_CBE
33.16
42%
-11
- C4 -
-
5E1S
1
A:
[27-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
-------------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
441
Blastp_CBE
33.08
40%
0
- C4 -
-
4UWY
1
FGFR1_HUMAN
A:
[25-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
-
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
398
Blastp_CBE
33.05
39%
-15
- C4 -
-
3GQL
1
FGFR1_HUMAN
A:
[36-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
------------------
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
L
T
S
N
--
Q
E
Y
L
D
L
S
-------------------------------------
161
Blastp_CBE
33.02
42%
-2
- C4 -
-
3ETA
1
B:
[24-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
--
K
--
G
L
--
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
480
Blastp_CBE
32.98
40%
1
- C4 -
-
4UWB
3
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY-----------------
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
-------
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
523
Blastp_CBE
32.97
38%
-25
- C4 -
-
6J5L
1
A:
[23-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
------------
D
-----
K
----
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
-----
D
A
K
L
L
A
G
GEDVAPGP
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
------
I
Y
--
S
T
D
Y
Y
R
V
---
T
--
M
--
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
531
Blastp_CBE
32.94
38%
-32
- C4 -
-
6DKW
1
NTRK1_HUMAN
A:
[28-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
L
--
P
----
E
--
Q
D
-----
K
----
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
-----
D
A
K
L
L
A
G
GEDGP---
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
--------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
439
Blastp_CBE
32.89
40%
-12
- C4 -
-
5AM6
1
B:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
-------------------
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
342
Blastp_CBE
32.89
39%
-3
- C4 -
-
5NKE
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
S
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
491
Blastp_CBE
32.86
40%
-8
- C4 -
-
4F64
3
FGFR1_HUMAN
A:
[24-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
-
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
153
Blastp_CBE
32.90
42%
-3
- C4 -
-
5HZN
3
IGF1R_HUMAN
B:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP----------------------APP--
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
341
Blastp_CBE
32.89
39%
-3
- C4 -
-
5NKF
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---
S
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
132
Blastp_CBE
32.86
42%
-8
- C4 -
-
1JQH
1
C:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
-------VLAP--
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
-----------
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
507
Blastp_CBE
32.84
40%
2
- C4 -
-
3JS2
1
FGFR1_HUMAN
A:
[36-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGL---------------------
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
436
Blastp_CBE
32.75
40%
-6
- C4 -
-
3RHX
5
FGFR1_HUMAN
A:
[25-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
154
Blastp_CBE
32.72
42%
-2
- C4 -
-
5HZN
3
IGF1R_HUMAN
A:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP----------------------APP--
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
166
Blastp_CBE
32.67
42%
4
- C4 -
-
5HHW
2
?
A:
[26-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
----
R
K
G
G
K
GL
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
508
Blastp_CBE
32.66
38%
-20
- C4 -
-
6NSP
1
A:
[17-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
L
--
P
----
E
--
Q
D
-----
K
----
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
-----
D
A
---
A
G
GEDVAPGP
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
M
S
R
--
D
I
Y
--
S
T
D
Y
Y
R
V
G
G
R
T
--
M
--
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
460
Blastp_CBE
32.65
40%
-19
- C4 -
-
5UR1
1
B:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP---------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
--------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
497
Blastp_CBE
32.57
38%
-24
- C4 -
-
4PMS
1
A:
[16-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
L
-----------
D
-----
K
----
M
L
V
A
V
K
A
L
K
-----
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
-----
D
A
K
L
L
A
G
GEDVAPGP
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
M
S
R
--
D
I
Y
--
S
T
D
Y
Y
R
V
--
R
T
--
M
--
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
466
Blastp_CBE
32.57
40%
-9
- C4 -
-
5O4A
1
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY--------------------------EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
---------
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
465
Blastp_CBE
32.54
40%
-5
- C4 -
-
4WUN
1
FGFR1_HUMAN
A:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPLEYSY-
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
--------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
335
Blastp_CBE
32.57
39%
-2
- C4 -
-
6FNH
11
EPHA2_HUMAN
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---
S
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-----------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
319
Blastp_CBE
32.56
37%
9
- C4 -
-
4K33
1
A:
[25-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
-
D
P
K
W
E
L
S
R
A
R
L
T
L
G
--------------------------------
K
P
-----
L
G
E
G
A
F
G
Q
V
V
----
M
A
E
A
--
I
GIDK
D
--
R
A
A
---
K
P
----
V
T
V
A
V
K
M
L
K
-
D
D
-
A
T
D
K
D
L
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
----
T
Q
G
--
G
-
P
-
L
Y
--
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
-----
L
------
R
-----------
A
RRPPGLDYSF
D
T
----
S
--------EQL--
T
F
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
V
H
--
N
L
D
Y
Y
K
--
E
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
I
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
A
N
----
C
T
---
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
V
L
T
--------------------------------------------------
150
Blastp_CBE
32.54
42%
0
- C4 -
-
5HZN
3
IGF1R_HUMAN
E:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP----------------------APP--
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
137
Blastp_CBE
32.54
42%
-1
- C4 -
-
3QQU
1
D:
[20-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
------LAP---
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
K
G
G
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
136
Blastp_CBE
32.53
42%
1
- C4 -
-
5FXQ
1
A:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
--
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
------NPVLAP
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
----
R
---
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
524
Blastp_CBE
32.42
38%
-21
- C4 -
-
4YPS
1
A:
[23-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
K
V
F
LAEC
H
N
L
L
-----------
D
-----
K
----
M
L
V
A
V
K
A
L
-----
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
-----
D
A
K
L
L
A
G
GEDVAPGP
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
--
M
S
R
--
D
I
Y
--
S
T
D
Y
Y
R
V
---
T
--
M
--
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
396
Blastp_CBE
32.42
39%
-10
- C4 -
-
3GQL
1
C:
[36-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
------------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
L
T
S
N
--
Q
E
Y
-----------------------------------------
496
Blastp_CBE
32.44
38%
-27
- C4 -
-
4PMT
1
A:
[16-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
------------
D
-----
K
----
M
L
V
A
V
K
A
L
------------
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
-----
D
A
K
L
L
A
G
GEDVAPGP
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
--
S
R
--
D
I
Y
--
S
T
D
Y
Y
R
V
---
T
--
M
--
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
533
Blastp_CBE
32.43
38%
-36
- C4 -
-
5JFW
1
A:
[28-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
L
--
P
----
E
--
Q
D
-----
K
----
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
------------VAPGP---
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
--------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
370
Blastp_CBE
32.42
39%
-4
- C4 -
-
5I9V
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
S
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
----------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
534
Blastp_CBE
32.31
38%
-32
- C4 -
-
5JFV
1
A:
[28-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
L
--
P
----
E
--
Q
D
-----
K
----
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
------------VAPGP---
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
--------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
353
Blastp_CBE
32.34
39%
-7
- C4 -
-
5NK3
2
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
---
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
478
Blastp_CBE
32.33
40%
2
- C4 -
-
4UWC
9
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY-----------------
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
470
Blastp_CBE
32.27
40%
-5
- C4 -
-
5EW8
1
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
----
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
78
Blastp_CBE
32.31
99%
-3
- C4 -
-
4IWD
1
A:
[4-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
T
V
H
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
S
L
-------------------
I
----
V
H
F
N
E
V
-----
I
G
R
G
H
F
G
C
V
Y
----
H
G
T
L
--
L
----
D
--
N
D
G
---
K
K
----
I
H
C
A
V
K
S
L
N
-
R
I
-
T
D
I
G
E
V
S
Q
F
L
T
E
G
I
I
M
K
D
F
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
S
E
G
--
S
-
P
-
L
V
--
V
L
-
P
Y
M
K
H
G
D
L
R
N
F
-----
I
------
R
-----------
N
----------
E
T
----
H
N
------
P
-----
T
V
K
D
L
I
G
--------
F
G
--
L
--------
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
E
K
--
F
T
----
V
K
V
A
D
F
G
L
A
R
--
D
M
Y
--
D
K
E
Y
Y
S
V
H
N
----
K
--
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
G
A
P
P
Y
P
D
--
V
N
T
F
D
I
T
V
Y
L
L
Q
G
R
R
L
L
Q
P
E
Y
----
C
P
---
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
L
V
-----------------
S
R
I
S
A
I
F
S
T
F
I
G
--
E
H
H
H
H
---------------------------------------
509
Blastp_CBE
32.30
38%
-51
- C4 -
-
2QOB
1
A:
[18-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
D
K
V
-----
V
G
A
G
E
F
G
E
V
C
----
S
G
-
L
--
K
----
L
--
P
S
K
---
K
E
----
I
S
V
A
I
K
T
L
K
-
V
G
-
Y
T
E
K
Q
R
R
D
F
L
G
E
A
S
I
M
G
Q
F
D
-
H
P
N
I
I
R
L
E
G
V
V
T
K
--
S
K
-----
P
-
V
M
--
I
V
-
T
E
M
E
N
G
S
L
D
S
F
-----
L
------
R
-----------
K
----------
H
D
----
A
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
------------------
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
Y
G
E
R
P
Y
W
E
--
M
S
N
Q
D
V
I
K
A
V
D
E
G
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
-----------------
S
---------------------------------------------------------
361
Blastp_CBE
32.29
39%
-6
- C4 -
-
5IA2
3
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
532
Blastp_CBE
32.22
38%
-34
- C4 -
-
5JFX
1
A:
[28-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
L
--
P
----
E
--
Q
D
-----
K
----
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
------------VAPGP---
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
--------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
453
Blastp_CBE
32.27
40%
-6
- C4 -
-
6C1C
1
FGFR1_HUMAN
A:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPSY----
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
--------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
364
Blastp_CBE
32.26
39%
-6
- C4 -
-
5IA0
10
EPHA2_HUMAN
B:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
-------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
535
Blastp_CBE
32.23
38%
-33
- C4 -
-
5JFS
1
A:
[28-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
L
--
P
----
E
--
Q
D
-----
K
----
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
------------VAPGP---
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
--------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
371
Blastp_CBE
32.22
39%
-4
- C4 -
-
5I9U
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
S
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
452
Blastp_CBE
32.21
40%
-14
- C4 -
-
6C1C
1
B:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
-
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP---------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
211
Blastp_CBE
32.18
41%
-47
- C4 -
-
4WA9
1
ABL1_HUMAN
A:
[22-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
------------------------
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
-------
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
454
Blastp_CBE
32.13
40%
-23
- C4 -
-
6C1B
1
B:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
----
L
A
E
A
--
I
---------------RV--
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
339
Blastp_CBE
32.17
39%
-1
- C4 -
-
5NKH
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
S
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
127
Blastp_CBE
32.15
42%
4
- C4 -
-
3I81
1
A:
[26-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
-----
E
N
NPVLAP
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
----
R
----L-
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
368
Blastp_CBE
32.13
39%
-6
- C4 -
-
5I9X
5
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
----------E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
340
Blastp_CBE
32.12
39%
-1
- C4 -
-
5NKG
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
S
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
537
Blastp_CBE
32.11
40%
-9
- C4 -
-
6MZW
1
FGFR1_HUMAN
A:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
--------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
349
Blastp_CBE
32.10
39%
-4
- C4 -
-
5NK7
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
425
Blastp_CBE
32.09
40%
-4
- C4 -
-
4ZSA
1
B:
[27-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
----------
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
506
Blastp_CBE
32.08
40%
3
- C4 -
-
3JS2
1
B:
[36-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
351
Blastp_CBE
32.07
39%
-2
- C4 -
-
5NK5
1
A:
[22-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
---
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
S
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
T
-
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
472
Blastp_CBE
32.01
40%
-2
- C4 -
-
4V05
3
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
------
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
358
Blastp_CBE
32.06
39%
-2
- C4 -
-
5IA5
3
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
499
Blastp_CBE
32.02
38%
-15
- C4 -
-
4PMM
2
A:
[16-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
L
-----------
D
-----
K
----
M
L
V
A
V
K
A
L
K
-----
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
-----
D
A
K
L
L
A
G
GEDVAPGP
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
M
S
R
--
D
I
Y
--
S
T
D
Y
Y
R
V
G
G
R
T
--
M
--
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
433
Blastp_CBE
31.98
40%
-2
- C4 -
-
5ZV2
1
B:
[25-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR---------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
-----------
D
Y
Y
K
--
K
T
---
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
459
Blastp_CBE
32.01
40%
-1
- C4 -
-
6C18
1
FGFR1_HUMAN
A:
[26-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGSY---
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
--------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
142
Blastp_CBE
31.98
40%
0
- C4 -
-
3LVP
2
D:
[36-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
--
P
D
E
W
-------------------
E
----
V
A
R
E
K
I
TMSRE
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
------------
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
-------VLAP--
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
----
R
K
G
G
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
164
Blastp_CBE
31.97
42%
11
- C4 -
-
4IBM
1
?
B:
[25-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
------
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
----
R
K
G
G
K
GL
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
502
Blastp_CBE
31.93
40%
-9
- C4 -
-
4RWJ
1
B:
[36-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPG-------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
-------------
Y
K
--
K
T
T
-
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
485
Blastp_CBE
31.88
40%
-0
- C4 -
-
4NKA
3
FGFR1_HUMAN
A:
[24-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP--------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
-----------
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
451
Blastp_CBE
31.83
40%
2
- C4 -
-
6C1O
1
FGFR1_HUMAN
A:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPY-----
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
484
Blastp_CBE
31.81
40%
5
- C4 -
-
4NKA
2
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
--------
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
163
Blastp_CBE
31.79
42%
-3
- C4 -
-
1I44
1
A:
[25-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
------------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
489
Blastp_CBE
31.71
40%
-2
- C4 -
-
4F65
5
FGFR1_HUMAN
A:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP-------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
--------------
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
458
Blastp_CBE
31.71
40%
-8
- C4 -
-
6C18
1
B:
[26-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
----------------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
444
Blastp_CBE
31.69
40%
-6
- C4 -
-
1FGI
1
B:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
----------
D
Y
Y
K
--
K
---
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
354
Blastp_CBE
31.71
39%
-2
- C4 -
-
5NK2
2
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
158
Blastp_CBE
31.69
42%
14
- C4 -
-
3LW0
2
IGF1R_HUMAN
A:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP----------------------PP---
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
---
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
437
Blastp_CBE
31.64
40%
12
- C4 -
-
5B7V
1
B:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR---------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
---------
D
Y
Y
K
--
K
T
T
-
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
462
Blastp_CBE
31.66
40%
-30
- C4 -
-
5UQ0
1
B:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------RV--
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
-------------------------
L
P
V
K
W
M
A
P
E
A
L
--
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
334
Blastp_CBE
31.65
39%
2
- C4 -
-
6FNH
6
EPHA2_HUMAN
B:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
-------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
350
Blastp_CBE
31.64
39%
-0
- C4 -
-
5NK6
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
---
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
366
Blastp_CBE
31.63
39%
-6
- C4 -
-
5I9Z
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
--
G
E
V
Y
----
K
G
M
L
--
K
----
T
---------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
-------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
369
Blastp_CBE
31.61
39%
-10
- C4 -
-
5I9W
3
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
-----------------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
-------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
449
Blastp_CBE
31.60
40%
-1
- C4 -
-
6MZQ
1
FGFR1_HUMAN
A:
[30-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
-------------EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
--------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
348
Blastp_CBE
31.57
39%
2
- C4 -
-
5NK8
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
----
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
S
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
165
Blastp_CBE
31.55
42%
10
- C4 -
-
4IBM
1
?
A:
[25-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
----
R
K
G
G
K
GL
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
359
Blastp_CBE
31.51
39%
-0
- C4 -
-
5IA4
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
-------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
355
Blastp_CBE
31.54
39%
-4
- C4 -
-
5NK1
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
344
Blastp_CBE
31.53
39%
-0
- C4 -
-
5NKC
2
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
-----
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
356
Blastp_CBE
31.51
39%
-2
- C4 -
-
5NK0
1
A:
[22-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
S
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
367
Blastp_CBE
31.44
39%
-2
- C4 -
-
5I9Y
4
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
---------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
434
Blastp_CBE
31.47
40%
9
- C4 -
-
5ZV2
1
FGFR1_HUMAN
A:
[25-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP---------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
----
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
481
Blastp_CBE
31.46
40%
19
- C4 -
-
4UWB
4
FGFR1_HUMAN
A:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYS------------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
-
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
473
Blastp_CBE
31.45
40%
16
- C4 -
-
4V05
4
FGFR1_HUMAN
A:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPG-------------------------------EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--------
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
157
Blastp_CBE
31.44
42%
14
- C4 -
-
3LW0
3
IGF1R_HUMAN
B:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP----------------------PP---
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
---
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
352
Blastp_CBE
31.43
39%
-0
- C4 -
-
5NK4
2
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
-----------------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
487
Blastp_CBE
31.39
40%
1
- C4 -
-
4NK9
5
FGFR1_HUMAN
A:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
-----------
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
438
Blastp_CBE
31.34
40%
11
- C4 -
-
5B7V
1
FGFR1_HUMAN
A:
[25-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP-------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
-------
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
501
Blastp_CBE
31.29
40%
5
- C4 -
-
4RWL
1
B:
[36-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
----------
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
155
Blastp_CBE
31.35
42%
10
- C4 -
-
3LW0
2
D:
[23-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP----------------------PP---
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
R
---
K
--
G
L
--
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
492
Blastp_CBE
31.29
40%
-2
- C4 -
-
4F63
3
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
-
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
----------
D
Y
Y
K
--
K
---
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
347
Blastp_CBE
31.34
39%
-3
- C4 -
-
5NK9
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
T
--
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
373
Blastp_CBE
31.29
39%
-3
- C4 -
-
1MQB
1
B:
[49-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
----------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
541
Blastp_CBE
31.22
40%
5
- C4 -
-
5FLF
3
FGFR1_HUMAN
D:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLE-----------------------------EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
G
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
536
Blastp_CBE
31.22
40%
-11
- C4 -
-
6MZW
1
B:
[26-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
-
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP---------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
----------------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
343
Blastp_CBE
31.28
39%
-3
- C4 -
-
5NKD
2
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
-----------------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
467
Blastp_CBE
31.22
40%
16
- C4 -
-
5O4A
2
FGFR1_HUMAN
A:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPG-------------------------------EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
461
Blastp_CBE
31.20
40%
6
- C4 -
-
5UR1
1
FGFR1_HUMAN
A:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
-
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPY-----
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
--------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
357
Blastp_CBE
31.24
39%
-6
- C4 -
-
5NJZ
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
429
Blastp_CBE
31.20
40%
-1
- C4 -
-
4RWK
1
B:
[36-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
M
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
---------
I
D
Y
Y
K
--
K
T
--
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
442
Blastp_CBE
31.23
40%
-4
- C4 -
-
2FGI
1
B:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
----------
D
Y
Y
K
--
K
---
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
323
Blastp_CBE
31.22
39%
-4
- C4 -
-
6Q7D
1
?
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
-------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
168
Blastp_CBE
31.20
42%
10
- C4 -
-
3EKN
1
A:
[26-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
Y
--
E
T
D
Y
Y
----
R
---
K
GL
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
542
Blastp_CBE
31.12
40%
4
- C4 -
-
5FLF
1
FGFR1_HUMAN
C:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR---------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
G
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
387
Blastp_CBE
31.18
38%
-47
- C4 -
-
5MJA
1
EPHB1_HUMAN
A:
[28-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
I
E
E
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
R
L
-------
K
--
L
P
G
---
K
R
----
E
I
V
A
I
K
T
L
K
-
A
G
-
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
-
H
R
N
I
I
R
L
E
G
V
V
T
K
--
S
R
---
P
-
V
-
M
I
--
I
T
-
E
F
M
E
N
G
A
L
D
S
F
-----
L
------
R
-----------
Q
----------
N
D
----
G
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
Y
L
Q
--
D
D
T
S
D
P
------------
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
--
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
-----------------
N
T
L
D
K
M
I
---------------------------------------------------
443
Blastp_CBE
31.16
40%
11
- C4 -
-
2FGI
1
FGFR1_HUMAN
A:
[25-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
-
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
---
D
I
H
--
H
I
D
Y
Y
K
--
K
-
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
363
Blastp_CBE
31.15
39%
-5
- C4 -
-
5IA0
7
C:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
----
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
---
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
397
Blastp_CBE
31.13
39%
-0
- C4 -
-
3GQL
1
FGFR1_HUMAN
B:
[36-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP-------------------------------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
------------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
L
T
S
N
--
Q
E
------------------------------------------
529
Blastp_CBE
31.12
40%
7
- C4 -
-
6NVL
1
FGFR1_HUMAN
A:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
------------
Y
Y
K
--
K
-
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
526
Blastp_CBE
31.11
40%
7
- C4 -
-
6NVL
1
D:
[24-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
----
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
---
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
-----
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
-------------
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
191
Blastp_CBE
31.04
41%
-10
- C4 -
-
1K3A
1
A:
[18-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
------------
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
346
Blastp_CBE
31.01
39%
1
- C4 -
-
5NKA
2
A:
[22-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
S
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
-----------------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
326
Blastp_CBE
30.96
39%
-4
- C4 -
-
6HEY
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--
S
-------E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
---------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
365
Blastp_CBE
30.92
39%
-2
- C4 -
-
5IA0
7
EPHA2_HUMAN
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
--------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
440
Blastp_CBE
30.89
40%
18
- C4 -
-
5AM6
1
FGFR1_HUMAN
A:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPG-------------------------------EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
482
Blastp_CBE
30.77
40%
-2
- C4 -
-
4NKS
1
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
-
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
----------
D
Y
Y
K
--
K
---
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
345
Blastp_CBE
30.81
39%
-0
- C4 -
-
5NKB
3
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
V
L
E
--
D
-
D
P
E
A
T
Y
T
T
--
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
431
Blastp_CBE
30.77
40%
2
- C4 -
-
5A4C
7
B:
[26-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
---------
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
490
Blastp_CBE
30.67
40%
-1
- C4 -
-
4F64
3
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
----------
D
Y
Y
K
--
K
---
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
338
Blastp_CBE
30.70
39%
2
- C4 -
-
5NKI
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
471
Blastp_CBE
30.67
40%
19
- C4 -
-
5EW8
1
FGFR1_HUMAN
A:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPG-------------------------------EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
333
Blastp_CBE
30.66
39%
-0
- C4 -
-
6FNH
5
C:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
----
G
---
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
337
Blastp_CBE
30.65
39%
-5
- C4 -
-
6FNF
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
525
Blastp_CBE
30.56
38%
-10
- C4 -
-
4YNE
2
A:
[23-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
K
V
F
LAEC
H
N
L
L
--
P
--------
D
-----
K
----
M
L
V
A
V
K
A
L
K
-
E
------
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
-----
D
A
K
L
L
A
G
GEDVAPGP
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
M
---------
S
T
D
Y
Y
----
R
T
--
M
--
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
169
Blastp_CBE
30.62
42%
4
- C4 -
-
3EKK
1
A:
[26-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
-------------------------L-
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
475
Blastp_CBE
30.60
40%
10
- C4 -
-
4V04
6
FGFR1_HUMAN
A:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYS------------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
------------
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
435
Blastp_CBE
30.52
40%
2
- C4 -
-
3RHX
2
B:
[25-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
----------
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
329
Blastp_CBE
30.52
39%
-4
- C4 -
-
6HEV
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
360
Blastp_CBE
30.51
39%
-0
- C4 -
-
5IA3
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
-------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
-----------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
336
Blastp_CBE
30.44
39%
-5
- C4 -
-
6FNG
6
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
----------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
362
Blastp_CBE
30.43
39%
-2
- C4 -
-
5IA1
2
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
-----------------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
374
Blastp_CBE
30.42
39%
5
- C4 -
-
1MQB
1
EPHA2_HUMAN
A:
[49-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
--------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
----------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
474
Blastp_CBE
30.40
40%
3
- C4 -
-
4V04
5
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
------------
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
321
Blastp_CBE
30.36
39%
-3
- C4 -
-
6Q7F
1
?
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
----------E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
---------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
464
Blastp_CBE
30.34
40%
-6
- C4 -
-
4WUN
1
B:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
------
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
322
Blastp_CBE
30.28
39%
-5
- C4 -
-
6Q7E
1
?
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
----------E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
448
Blastp_CBE
30.24
40%
3
- C4 -
-
6MZQ
1
B:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
AR-----------------------------------L----
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
---------------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
332
Blastp_CBE
30.16
39%
-3
- C4 -
-
6HES
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
320
Blastp_CBE
30.16
39%
-4
- C4 -
-
6Q7G
1
?
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
456
Blastp_CBE
30.15
40%
-2
- C4 -
-
6C19
1
B:
[30-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
330
Blastp_CBE
30.07
39%
-4
- C4 -
-
6HEU
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
559
Fugue
30.04
17%
-52
- C4 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
L
Y
E
-------------------
K
----
Y
M
I
A
E
D
-----
L
G
R
G
E
F
G
I
V
H
----
R
C
V
E
--
T
----
S
--
S
K
----------
K
T
Y
M
A
K
F
V
K
----
V
K
G
T
D
Q
V
L
V
K
K
E
I
S
I
L
N
I
A
R
-
H
R
N
I
L
H
L
H
E
S
F
E
S
--
M
E
---
E
-
L
-
V
M
--
I
F
-
E
F
I
S
G
L
D
I
F
E
R
-----
I
------
N
-----------
T
----------
S
A
----
F
E
------
L
-----
N
E
R
E
I
V
S
--------
Y
V
--
H
--------
Q
V
C
E
A
L
Q
F
L
H
S
H
N
I
G
H
F
D
I
R
P
E
N
I
I
Y
Q
T
R
RS
S
T
----
I
K
I
I
E
F
G
Q
A
R
--
Q
L
K
--
P
G
D
N
F
R
L
L
F
T
A
-------
P
E
Y
Y
A
P
E
V
H
Q
H
D
V
V
S
T
A
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
-
G
I
N
P
F
L
A
--
E
T
N
Q
Q
I
I
E
N
I
M
N
A
E
Y
T
F
D
E
E
A
FKE-
I
S
---
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
K
S
R
M
T
A
S
E
A
L
QHPWLK-----------
Q
K
I
E
R
V
S
T
K
V
I
R
TL
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
324
Blastp_CBE
30.02
39%
-1
- C4 -
-
6Q7C
1
?
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
--
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
--------------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
488
Blastp_CBE
29.95
40%
5
- C4 -
-
4F65
4
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP---------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
-----------
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
328
Blastp_CBE
30.00
39%
1
- C4 -
-
6HEW
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
--------------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
446
Blastp_CBE
29.97
40%
-1
- C4 -
-
1AGW
1
B:
[29-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARR----------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
----------
D
Y
Y
K
--
K
---
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
325
Blastp_CBE
29.95
39%
-0
- C4 -
-
6Q7B
1
?
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
---------
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
--------------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
327
Blastp_CBE
29.69
39%
1
- C4 -
-
6HEX
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
----------------
K
K
E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
486
Blastp_CBE
29.64
40%
19
- C4 -
-
4NK9
2
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
------------
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
528
Blastp_CBE
29.49
40%
2
- C4 -
-
6NVL
1
FGFR1_HUMAN
B:
[24-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
---
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGL------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
--------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
331
Blastp_CBE
29.46
39%
-1
- C4 -
-
6HET
1
A:
[22-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
K
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
M
L
--
K
----
T
----------E---
V
P
V
A
I
K
T
L
K
-
A
G
-
Y
T
E
K
Q
R
V
D
F
L
G
E
A
G
I
M
G
Q
F
S
-
H
H
N
I
I
R
L
E
G
V
I
----
S
K
Y
--
K
-
P
-
M
M
--
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
-----
L
------
R
-----------
E
----------
K
D
----
G
E
------
F
-----
S
V
L
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
Y
G
E
R
P
Y
W
E
--
L
S
N
H
E
V
M
K
A
I
N
D
G
F
R
L
P
T
P
M
D
----
C
P
---
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
-----------------
S
---------------------------------------------------------
186
Blastp_CBE
29.30
41%
-6
- C4 -
-
3F5P
1
IGF1R_HUMAN
A:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
------LAP---
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
468
Blastp_CBE
29.09
40%
26
- C4 -
-
5O49
1
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPG-------------------------------EQL--
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
---------
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
477
Blastp_CBE
29.01
40%
21
- C4 -
-
4V01
6
FGFR1_HUMAN
A:
[24-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
-----
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPP--------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
------------
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
178
Blastp_CBE
29.00
41%
-7
- C4 -
-
3F5P
1
IGF1R_HUMAN
I:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP---------------P-----
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
182
Blastp_CBE
28.95
41%
-3
- C4 -
-
3F5P
1
IGF1R_HUMAN
E:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
-------PVLAP-
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
183
Blastp_CBE
28.82
41%
-4
- C4 -
-
3F5P
1
IGF1R_HUMAN
D:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP---------------LAP---
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
530
Blastp_CBE
28.75
38%
-2
- C4 -
-
6DKW
1
B:
[28-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
K
V
F
LAEC
H
N
L
L
--
P
----
E
--
Q
D
-----
K
----
M
L
V
A
V
K
A
L
K
-
E
A
-
S
E
S
A
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
Q
-
H
Q
H
I
V
R
F
F
G
V
C
----
T
E
G
--
R
-
P
-
L
L
M-
V
F
-
E
Y
M
R
H
G
D
L
N
R
F
-----
L
------
R
-----------------------
S
----
H
G
------
P
-----
D
A
K
----GP------
L
G
--
L
GQLLAVAS
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
Q
G
--
L
V
----
V
K
I
G
D
F
G
--------------------
T
--
M
--
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
G
K
Q
P
W
Y
Q
--
L
S
N
T
E
A
I
D
C
I
T
Q
G
R
E
L
E
R
P
R
A
----
C
P
---
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
-----------------
A
R
L
Q
A
L
----------------------------------------------------
185
Blastp_CBE
28.73
41%
-5
- C4 -
-
3F5P
1
IGF1R_HUMAN
B:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
-------LAP---
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
184
Blastp_CBE
28.70
41%
3
- C4 -
-
3F5P
1
IGF1R_HUMAN
C:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
------PVLAP-
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
179
Blastp_CBE
28.66
41%
-4
- C4 -
-
3F5P
1
IGF1R_HUMAN
H:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
M
------LAP---
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
177
Blastp_CBE
28.66
41%
-5
- C4 -
-
3F5P
1
IGF1R_HUMAN
J:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LR----------------P-----
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
171
Blastp_CBE
28.59
41%
-5
- C4 -
-
3F5P
6
T:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP---------------P-----
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
181
Blastp_CBE
28.58
41%
3
- C4 -
-
3F5P
1
IGF1R_HUMAN
F:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
-------PVLAP-
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
180
Blastp_CBE
28.54
41%
6
- C4 -
-
3F5P
1
IGF1R_HUMAN
G:
[27-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
V
A
KG
V
----
V
--
K
D
E
---
P
E
----
T
R
V
A
I
K
T
V
N
-
E
A
-
A
S
M
R
E
R
I
E
F
L
N
E
A
S
V
M
K
E
F
N
-
C
H
H
V
V
R
L
L
G
V
V
----
S
Q
G
--
Q
-
P
T
L
V
--
I
M
-
E
L
M
T
R
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
-------PVLAP-
P
-----
S
L
S
K
M
I
Q
--------
M
A
--
G
--------
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
---------
T
D
R
K
G
G
K
GL
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
L
L
D
K
P
D
N
----
C
P
---
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
-----------------
S
S
I
-------------------------------------------------------
476
Blastp_CBE
28.49
40%
17
- C4 -
-
4V01
6
B:
[28-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
--
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
------PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRP---------------------------------QL---
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
------------
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
386
Blastp_CBE
28.28
38%
-19
- C4 -
-
5MJA
1
B:
[28-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
I
E
E
V
-----
I
G
A
G
E
F
G
E
V
Y
----
K
G
R
L
-------
K
--
L
P
G
---
K
R
----
E
I
V
A
I
K
T
L
K
-
A
G
-
Y
S
E
K
Q
R
R
D
F
L
S
E
A
S
I
M
G
Q
F
D
-
H
R
N
I
I
R
L
E
G
V
V
T
K
--
S
R
---
P
-
V
-
M
I
--
I
T
-
E
F
M
E
N
G
A
L
D
S
F
-----
L
------
R
-----------
Q
----------
N
D
----
G
Q
------
F
-----
T
V
I
Q
L
V
G
--------
M
L
--
R
--------
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
S
N
--
L
V
----
C
K
V
S
D
F
G
L
S
R
--
Y
L
Q
--------
T
T
S
S
L
G
G
K
--
I
P
V
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
F
G
E
R
P
Y
W
D
--
M
S
N
Q
D
V
I
N
A
I
E
Q
D
Y
R
L
P
P
P
M
D
----
C
P
---
A
A
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
S
R
P
R
F
A
E
I
V
-----------------
N
T
L
D
K
M
I
---------------------------------------------------
121
Blastp_CBE
27.88
41%
-49
- C4 -
-
4FF8
1
A:
[80-297]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
D
-
H
P
H
V
A
K
L
------------------
V
--
I
L
-
P
F
M
K
H
G
D
L
H
A
F
LLASR
I
-------------------------------------------------
P
L
Q
T
L
V
R
--------
F
M
--
V
--------
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
E
D
--
M
T
----
V
C
V
A
-------------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
G
Q
T
P
Y
A
G
--
I
E
N
A
E
I
Y
N
Y
L
I
G
G
N
R
L
K
Q
P
P
E
----
C
M
-----
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
-----------------
M
E
L
E
N
I
L
---------------------------------------------------
282
Blastp_CBE
27.72
41%
15
- C4 -
-
1RQQ
1
INSR_HUMAN
A:
[25-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
--
T
-------
D
R
K
G
G
K
GL
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
294
Blastp_CBE
27.55
41%
17
- C4 -
-
4XLV
1
?
A:
[47-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
--
T
-------
D
R
K
G
G
K
GL
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
281
Blastp_CBE
27.52
41%
18
- C4 -
-
1RQQ
1
B:
[25-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
--
T
-------
D
R
K
G
G
K
GL
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
236
Blastp_CBE
27.24
41%
21
- C4 -
-
1IR3
1
A:
[25-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
--
T
-------
D
R
K
G
G
K
GL
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
219
Blastp_CBE
27.24
41%
19
- C4 -
-
2Z8C
1
A:
[22-281]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
--
T
-------
D
R
K
G
G
K
GL
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
237
Blastp_CBE
27.19
41%
16
- C4 -
-
1GAG
1
A:
[25-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
S
F
G
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
--
T
-------
D
R
K
G
G
K
GL
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
276
Blastp_CBE
26.60
41%
20
- C4 -
-
3BU5
1
A:
[25-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
Q
G
---
M
V
Y
----
E
G
N
A
--
R
----
D
II
K
G
E
---
A
E
----
T
R
V
A
V
K
T
V
N
-
E
S
-
A
S
L
R
E
R
I
E
F
L
N
E
A
S
V
M
K
G
F
T
-
C
H
H
V
V
R
L
L
G
V
V
----
S
K
G
--
Q
-
P
T
L
V
--
V
M
-
E
L
M
A
H
G
D
L
K
S
Y
-----
L
------
R
-----------
S
LRP-------
E
A
----
E
N
NPGRPP
P
-----
T
L
Q
E
M
I
Q
--------
M
A
--
A
--------
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
H
D
--
F
T
----
V
K
I
G
D
F
G
M
T
R
--
D
I
E
--
T
-------
D
R
K
G
G
K
GL
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
A
E
Q
P
Y
Q
G
--
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
Y
L
D
Q
P
D
N
----
C
P
---
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
-----------------
N
---------------------------------------------------------
558
Fugue
24.37
13%
-22
- C4 -
-
3UQC
-
MVINL_MYCTU
A:
[20-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
V
P
G
A
R
-------------------
I
ANGR
Y
R
L
L
I
F
-----
H
G
G
V
P
P
L
Q
F
W
----
Q
A
L
D
--
T
----
A
--
L
-
D
---
R
Q
----
V
A
L
T
F
V
D
P
Q
-
G
V
-
L
P
D
D
V
L
Q
E
T
L
S
R
T
L
R
L
S
R
I
D
-
K
P
G
V
A
R
V
L
D
V
V
H
T
--
R
A
G
----
G
-
L
V
--
V
A
-
E
W
I
R
G
G
S
L
Q
E
V
-----
A
------
D
-----------
T
-----------------
S
------
P
-----
S
P
V
G
A
I
R
--------
A
M
--
Q
--------
S
L
A
A
A
A
D
A
A
H
R
A
G
V
A
L
S
I
D
H
P
S
R
V
R
V
S
I
D
--
G
D
----
V
V
L
A
Y
P
A
T
M
P
--
D
A
-----------------------------------
N
P
Q
D
D
I
R
G
I
G
A
S
L
Y
A
L
L
V
-
N
R
W
P
L
P
E
AG
V
R
S
G
L
A
P
A
E
R
D
T
A
G
Q
P
I
E
P
A
D
IDRD
I
P
---
F
Q
I
S
A
V
A
A
R
S
V
Q
G
D
G
G
I
R
S
-
A
S
T
L
L
-----------------
N
L
M
Q
Q
A
T
A
--------------------------------------------------
315
Blastp_CBE
23.31
41%
-27
- C4 -
-
3DK6
1
ABL1_MOUSE
B:
[8-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
F
G
E
V
Y
----
E
G
V
W
-----------
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
---
D
T
-----
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
---
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
C---------
N
R
----
Q
E
------
V
-----
S
A
V
V
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
T
--
G
D
T
--
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
P
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
432
Blastp_CBE
22.81
40%
22
- C4 -
-
5A4C
6
FGFR1_HUMAN
A:
[22-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
----------
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
450
Blastp_CBE
22.80
40%
-12
- C4 -
-
6C1O
1
B:
[26-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
-----NRV-
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPG------------------------------------
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
--------------------------
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
463
Blastp_CBE
21.88
40%
-2
- C4 -
-
5UQ0
1
FGFR1_HUMAN
A:
[26-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
-----PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPG-------------------------------L----
S
S
K
D
L
V
S
--------
C
A
--
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
-------------------------
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
-
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
308
Blastp_CBE
19.52
41%
-4
- C4 -
-
4XEY
1
ABL1_HUMAN
B:
[26-382]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
G
G
Q
Y
G
E
V
Y
----
E
G
V
W
--
E
----
S
--
S
K
K
---
Y
S
----
L
T
V
A
V
K
T
L
K
-
E
Y
-
H
D
T
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
--
L
E
P
--
P
-
F
-
Y
I
--
I
T
-
E
F
M
T
Y
G
N
L
L
D
Y
-----
L
------
R
-----------
E
CNR-------
Q
E
----
V
N
------
A
-----
V
V
--
L
L
Y
--------
M
A
--
T
--------
Q
I
S
S
A
M
E
Y
---
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
--
H
L
----
V
K
V
A
D
F
G
L
S
R
--
L
M
---
T
G
D
T
Y
T
A
H
--
A
G
A
K
--
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
G
M
S
P
Y
P
G
--
I
D
L
S
Q
V
Y
E
L
L
E
K
D
Y
R
M
E
R
P
E
G
----
C
P
---
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
-----------------
Q
A
F
E
T
M
F
---------------------------------------------------
406
Blastp_CBE
19.34
40%
7
- C4 -
-
5AM7
1
B:
[3-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
M
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
--------------------
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
-----
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
455
Blastp_CBE
19.20
40%
-1
- C4 -
-
6C1B
1
FGFR1_HUMAN
A:
[11-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
----
H
N
------
P
------------------------
Y
--------
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
--------------------
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
483
Blastp_CBE
18.90
40%
8
- C4 -
-
4NKS
1
FGFR1_HUMAN
A:
[9-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
---------
A
T
E
K
D
L
S
D
L
I
S
E
-
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
----
H
N
------
P
EE---------------------------------
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
--------
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
407
Blastp_CBE
17.90
40%
25
- C4 -
-
5AM7
1
FGFR1_HUMAN
A:
[3-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
L
K
-
S
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
M
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
----
H
N
------
P
EEQL-
S
S
K
D
L
V
S
--------
C
--------------------
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
N
G
R
--
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------
527
Blastp_CBE
16.84
40%
23
- C4 -
-
6NVL
1
FGFR1_HUMAN
C:
[9-303]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
----
L
A
E
A
--
I
----
G
--
L
D
K
---
D
K
PNRV
T
K
V
A
V
K
M
----
D
-
A
T
E
K
D
L
S
D
L
I
S
E
M
--
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
---
D
G
--
P
-
L
-
Y
V
--
I
V
-
E
Y
A
S
K
G
N
L
R
E
Y
-----
L
------
Q
ARRPPGLEYSY
N
----------
P
S
----
H
N
------
P
EEQ--------------------------------
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
--
N
V
----
M
K
I
A
D
F
G
L
A
R
--
D
I
H
--
H
I
D
Y
Y
K
--
K
T
T
------
P
V
K
W
M
A
P
E
A
-----
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
G
S
P
Y
P
G
--
V
P
V
E
E
L
F
K
L
L
K
E
G
H
R
M
D
K
P
S
N
----
C
T
---
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
-----------------
E
D
L
D
R
I
V
A
--------------------------------------------------