@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MK07_HUMAN: (2020-09-16 )
MAEPLKEEDGEDGSAEPPGPVKAEPAHTAASVAAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAPDTIDLTLQPPPPVSEPAPPKKDGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGASGGPSTDPLAGLVLSDNDRSLLERWTRMARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIATSTSLLAAQSLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQDP
Atome Classification :
(448 SA)
.........10........20........30........40........50........60........70..-......80.....-...90........100.......110.......120-...-....130.......140.......150.......160.........170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......------------------270.......280........290.......300--.......310----------.------------...--------.----..--------..---320.......330.......340.......350.......--360.---.--....-.--.370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAEPLKEEDGEDGSAEPPGPVKAEPA
H
T
A
A
S
V
A
A
K
N
L
A
L
L
K
AR
S
F
D
V
T
F
DVGD
E
Y
E
I
I
E
T
IGNG
A
Y
G
V
V
S
S
A
R
-
R
RLTG
Q
Q
V
A
I
K
KI-P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
FKHD
N
I
I
A
I
K
D
I
LR-PTV-PYGE
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
IHSSQPL
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
RDLKPS
N
L
L
VNENC
E
L
K
IGDFGMARGLCTSP
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
WYR
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
RQLFPG
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
LGTP-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
SLP--PRQPVPWE------------T------------VYP--------G----A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
LRFEPSA
R
I
S
A
A
A
A
LRH
P
F
L
AKYHDPDDEPDC--AP-P---F--DFAF-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
IRFQPSLQPVASEPGCPDVEMPSPWAPSGDCAMESPPPAPPPCPGPAP
D
T
I
D
L
TLQPPPPVSEPAPPKKDGAISD
N
T
K
A
A
L
K
A
A
L
L
K
S
L
R
S
R
LRDGPSAPLEAPEPRKPV
T
A
Q
E
R
Q
R
E
R
E
E
K
R
R
R
R
Q
E
R
A
K
E
R
E
K
R
R
Q
E
R
E
R
K
ERGAGASGGPSTD
P
L
A
G
L
V
LSDN
D
R
S
L
L
E
R
W
T
R
MARPAAPALTSVPAPAPAPTPTPTPVQPTSPPPGPVAQPTGPQPQSAGSTSGPVPQPACPPPGPAPHPTGPPGPIPVPAPPQIAT
S
T
S
L
L
A
A
Q
SLVPPPGLPGSSTPGVLPYFPPGLPPPDAGGAPQSSMSESP
D
V
N
L
V
T
Q
Q
L
S
K
S
QVEDPLPPVFSGTPKGSGAGYGVGF
D
L
E
E
F
L
N
Q
SFDMGVADGPQDGQA
D
S
A
S
L
S
A
S
L
L
A
D
W
L
EGHGM
N
P
A
D
I
E
S
L
Q
R
E
IQMDS
P
M
L
L
ADLPDLQDP
21
Blastp_CBE
96.40
100%
-140
- C1 -
-
4IC7
1
MK07_HUMAN
D:
[49-401]
----------------------------------------------
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
96.07
100%
-136
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[1-347]
----------------------------------------------
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
HHSearch
95.85
100%
-135
- C1 -
-
4IC7
1
MK07_HUMAN
A:
[48-402]
---------------------------------------------
D
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
95.85
100%
-135
- C1 -
-
4IC7
1
MK07_HUMAN
A:
[48-402]
---------------------------------------------
D
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
R
Q
Q
I
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
HHSearch
95.49
100%
-136
- C1 -
-
4ZSG
6
MK07_HUMAN
A:
[3-347]
------------------------------------------------
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
HHSearch
94.80
100%
-126
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[2-348]
------------------------------------------------
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
94.62
100%
-126
- C1 -
-
5BYZ
7
MK07_HUMAN
A:
[1-348]
-----------------------------------------------
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
94.15
100%
-133
- C1 -
-
4ZSL
6
MK07_HUMAN
A:
[1-341]
----------------------------------------------------
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
93.92
100%
-133
- C1 -
-
4ZSJ
5
MK07_HUMAN
A:
[1-344]
-------------------------------------------------
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
93.21
100%
-133
- C1 -
-
5BYY
1
MK07_HUMAN
A:
[1-346]
------------------------------------------------
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
--------
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
92.94
100%
-132
- C1 -
-
5O7I
2
MK07_HUMAN
A:
[10-349]
-----------------------------------------------------
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
549
HHSearch
92.55
100%
-145
- C1 -
-
4B99
1
MK07_HUMAN
A:
[48-394]
----------------------------------------------
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
-------
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
-----
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
92.55
100%
-145
- C1 -
-
4B99
1
MK07_HUMAN
A:
[48-394]
----------------------------------------------
V
T
F
D
V
G
D
E
Y
E
I
I
E
T
I
G
N
G
A
Y
G
V
V
S
S
A
R
-
R
R
L
T
G
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
-------
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
-----
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
90.70
100%
-137
- C1 -
-
6HKM
1
MK07_HUMAN
A:
[6-347]
-----------------------------------------------------
E
Y
E
I
I
E
T
I
G
N
----
V
V
S
S
A
-------
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
-
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
--
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
----
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
89.74
100%
-135
- C1 -
-
6HKN
1
MK07_HUMAN
A:
[1-340]
-----------------------------------------------------
E
Y
E
I
I
E
T
I
---
A
Y
G
V
V
S
S
A
R
-
R
----
Q
Q
V
A
I
K
K
I
-
P
N
A
F
D
V
V
T
N
A
K
R
T
L
R
E
L
K
I
L
K
H
F
K
H
D
N
I
I
A
I
K
D
I
L
R
-
P
T
V
-
P
Y
G
E
F
K
S
V
Y
V
V
L
D
L
M
E
S
D
L
H
Q
I
I
H
S
S
Q
P
L
T
L
E
H
V
R
--
Y
F
L
Y
Q
L
L
R
G
L
K
Y
M
H
S
A
Q
V
I
H
R
D
L
K
P
S
N
L
L
V
N
E
N
C
E
L
K
I
G
D
F
G
M
A
R
G
L
C
T
S
P
A
E
H
Q
Y
F
M
T
E
Y
V
A
T
R
W
Y
R
A
P
E
L
M
L
S
L
H
E
Y
T
Q
A
I
D
L
W
S
V
G
C
I
F
G
E
M
L
A
R
R
Q
L
F
P
G
K
N
Y
V
H
------------------
Q
L
Q
L
I
M
M
V
L
G
T
P
-
S
P
A
V
I
Q
A
V
G
A
E
R
V
R
A
Y
I
Q
S
L
P
--
P
R
Q
P
V
P
W
E
------------
T
------------
V
Y
P
--------
G
----
A
D
--------
R
Q
---
A
L
S
L
L
G
R
M
L
R
F
E
P
S
A
R
I
S
A
A
A
A
L
R
H
P
F
L
A
K
Y
H
D
P
D
D
E
P
D
C
--
A
P
-
P
---
F
--
D
F
A
F
-
D
--
R
E
A
L
T
R
E
R
I
K
E
A
I
V
A
E
I
E
D
F
H
A
R
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
78.84
51%
-131
- C1 -
-
4QTB
16
MK03_HUMAN
A:
[37-372]
------------------------------------------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
-
D
H
V
R
K
T
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
-
A
S
T
-
L
E
A
-
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
S
Q
Q
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
M
K
A
R
N
Y
L
Q
S
L
P
--
S
K
T
K
V
A
W
A
------------
K
------------
L
F
P
--------
K
----
S
D
--------
S
K
---
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
A
--
E
E
-
P
---
F
--
T
F
A
M
-
E
--
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
78.68
51%
-134
- C1 -
-
6GES
4
MK03_HUMAN
A:
[37-372]
------------------------------------------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
-
D
H
V
R
K
T
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
-
A
S
T
-
L
E
A
-
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
S
Q
Q
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
M
K
A
R
N
Y
L
Q
S
L
P
--
S
K
T
K
V
A
W
A
------------
K
------------
L
F
P
--------
K
----
S
D
--------
S
K
---
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
A
--
E
E
-
P
---
F
--
T
F
A
M
-
E
--
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
78.36
47%
-138
- C1 -
-
1W82
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
78.33
51%
-130
- C1 -
-
4QTB
6
MK03_HUMAN
B:
[37-372]
------------------------------------------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
-
D
H
V
R
K
T
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
-
A
S
T
-
L
E
A
-
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
S
Q
Q
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
M
K
A
R
N
Y
L
Q
S
L
P
--
S
K
T
K
V
A
W
A
------------
K
------------
L
F
P
--------
K
----
S
D
--------
S
K
---
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
A
--
E
E
-
P
---
F
--
T
F
A
M
-
E
--
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
78.20
51%
-132
- C1 -
-
6GES
4
MK03_HUMAN
B:
[37-372]
------------------------------------------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
-
D
H
V
R
K
T
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
-
A
S
T
-
L
E
A
-
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
S
Q
Q
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
M
K
A
R
N
Y
L
Q
S
L
P
--
S
K
T
K
V
A
W
A
------------
K
------------
L
F
P
--------
K
----
S
D
--------
S
K
---
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
A
--
E
E
-
P
---
F
--
T
F
A
M
-
E
--
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
554
HHSearch
77.88
50%
-131
- C1 -
-
4ZZN
1
MK01_HUMAN
A:
[7-345]
----------------------------------------------
Q
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
-
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
-
A
P
T
--
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
H
D
-
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
-----------
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
77.77
47%
-140
- C1 -
-
3ITZ
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
77.74
51%
-135
- C1 -
-
2ZOQ
1
MK03_HUMAN
B:
[39-374]
------------------------------------------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
-
D
H
V
R
K
T
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
-
A
S
T
-
L
E
A
-
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
S
Q
Q
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
M
K
A
R
N
Y
L
Q
S
L
P
--
S
K
T
K
V
A
W
A
------------
K
------------
L
F
P
--------
K
----
S
D
--------
S
K
---
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
A
--
E
E
-
P
---
F
--
T
F
A
M
-
E
--
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
562
HHSearch
77.71
50%
-127
- C1 -
-
4QTE
22
MK01_HUMAN
A:
[17-358]
---------------------------------------------
G
Q
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
-
S
P
F
E
H
-
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
-
A
P
T
--
I
E
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
K
T
-
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
V
A
D
P
D
H
D
H
-
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
Q
P
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
77.61
47%
-141
- C1 -
-
3NNW
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
77.49
47%
-140
- C1 -
-
1ZZL
1
MK14_HUMAN
A:
[15-345]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
77.47
47%
-138
- C1 -
-
3GFE
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
77.36
50%
-128
- C1 -
-
2ZOQ
1
MK03_HUMAN
A:
[39-374]
------------------------------------------------
F
D
V
G
P
R
Y
T
Q
L
Q
Y
I
G
E
G
A
Y
G
M
V
S
S
A
Y
-
D
H
V
R
K
T
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
Q
I
L
L
R
F
R
H
E
N
V
I
G
I
R
D
I
L
R
-
A
S
T
-
L
E
A
-
M
R
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
S
Q
Q
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
I
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
I
A
D
P
E
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
M
K
A
R
N
Y
L
Q
S
L
P
--
S
K
T
K
V
A
W
A
------------
K
------------
L
F
P
--------
K
----
S
D
--------
S
K
---
A
L
D
L
L
D
R
M
L
T
F
N
P
N
K
R
I
T
V
E
E
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
T
D
E
P
V
A
--
E
E
-
P
---
F
--
T
F
A
M
-
E
--
L
D
D
L
P
K
E
R
L
K
E
L
I
F
Q
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
77.35
47%
-141
- C1 -
-
3NNU
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
77.30
47%
-137
- C1 -
-
3NNV
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
77.27
47%
-143
- C1 -
-
1W7H
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
77.25
47%
-139
- C1 -
-
3RIN
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
77.23
47%
-136
- C1 -
-
2ZB0
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
77.12
46%
-143
- C1 -
-
1BL6
1
MK14_HUMAN
A:
[37-367]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
77.05
47%
-142
- C1 -
-
1WBW
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
76.92
46%
-144
- C1 -
-
1BL7
1
MK14_HUMAN
A:
[37-367]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
76.87
47%
-136
- C1 -
-
1WBV
5
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
76.86
47%
-141
- C1 -
-
1W84
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
76.81
47%
-140
- C1 -
-
1W83
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
76.65
46%
-143
- C1 -
-
3E93
4
MK14_HUMAN
A:
[29-359]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
---
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
76.65
47%
-135
- C1 -
-
1WBN
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
76.64
47%
-137
- C1 -
-
1WBS
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
76.62
47%
-140
- C1 -
-
1YQJ
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
76.61
47%
-138
- C1 -
-
1WBT
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
76.56
47%
-141
- C1 -
-
2ZB1
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
--
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
76.51
47%
-137
- C1 -
-
3FLW
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
76.50
47%
-140
- C1 -
-
1WBO
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
76.45
46%
-137
- C1 -
-
5MZ3
1
MK14_HUMAN
A:
[27-357]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
76.44
47%
-135
- C1 -
-
1M7Q
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
76.40
47%
-136
- C1 -
-
1OUY
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
76.33
47%
-137
- C1 -
-
3FLZ
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
565
HHSearch
76.27
47%
-134
- C1 -
-
2YIX
1
MK14_HUMAN
A:
[10-346]
-------------------------------------------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
---
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
76.27
47%
-132
- C1 -
-
3S3I
1
MK14_HUMAN
A:
[15-345]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
76.24
47%
-140
- C1 -
-
2ZAZ
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
76.12
46%
-138
- C1 -
-
1OVE
2
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
76.05
47%
-137
- C1 -
-
1DI9
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
76.04
47%
-144
- C1 -
-
3FKO
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
K
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
---
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
76.02
47%
-137
- C1 -
-
3FMH
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
75.94
46%
-139
- C1 -
-
3E92
5
MK14_HUMAN
A:
[29-359]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
75.96
47%
-138
- C1 -
-
3FLQ
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
75.93
47%
-141
- C1 -
-
2GFS
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
----
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
75.93
47%
-136
- C1 -
-
3FKL
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
--------
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
75.86
47%
-142
- C1 -
-
3FSK
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
---------
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
75.73
47%
-137
- C1 -
-
3FLY
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
75.68
47%
-142
- C1 -
-
3FMM
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
75.66
46%
-140
- C1 -
-
5LAR
1
MK14_MOUSE
A:
[19-349]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
75.60
47%
-135
- C1 -
-
3U8W
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
75.59
46%
-134
- C1 -
-
4LOO
1
MK14_MOUSE
A:
[19-349]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
75.56
46%
-134
- C1 -
-
3GC7
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
75.56
47%
-142
- C1 -
-
3FMJ
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
---
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
75.50
46%
-141
- C1 -
-
1A9U
1
MK14_HUMAN
A:
[37-367]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
75.48
46%
-136
- C1 -
-
3KQ7
1
MK14_HUMAN
A:
[38-368]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
75.43
46%
-136
- C1 -
-
3MPT
4
MK14_HUMAN
A:
[29-359]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
75.40
47%
-143
- C1 -
-
3FLS
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
----
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
75.33
47%
-142
- C1 -
-
3FML
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
------
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
-
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
75.32
47%
-137
- C1 -
-
2YIX
1
MK14_HUMAN
A:
[15-345]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
75.31
47%
-146
- C1 -
-
3FL4
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
---
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
75.29
47%
-139
- C1 -
-
3FKN
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
75.27
47%
-147
- C1 -
-
3HV5
4
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
75.25
46%
-134
- C1 -
-
5XYY
1
MK14_HUMAN
A:
[38-368]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
75.24
47%
-133
- C1 -
-
1OUK
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
75.17
47%
-145
- C1 -
-
3BX5
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
-----------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
75.10
47%
-146
- C1 -
-
3GCU
3
MK14_HUMAN
B:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
75.00
47%
-140
- C1 -
-
3FMN
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
74.92
47%
-137
- C1 -
-
3FMK
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
74.92
47%
-147
- C1 -
-
3GCU
4
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
74.90
47%
-144
- C1 -
-
1OZ1
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
74.90
47%
-144
- C1 -
-
3FSF
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
-----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
74.86
47%
-137
- C1 -
-
3HRB
1
MK14_HUMAN
A:
[17-347]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
-----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
74.84
48%
-108
- C1 -
-
2B9H
1
FUS3_YEAST
A:
[5-351]
----------------------------------------------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
-
H
K
P
T
G
E
I
V
A
I
K
K
I
--
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
-
P
D
--
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
--
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
----------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
------------------
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
--
M
Y
P
A
A
P
L
E
------------
K
------------
M
F
P
--------
R
----
V
N
--------
P
K
---
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
EP
I
P
-
P
---
S
--
F
F
E
F
-
D
HY
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
74.84
48%
-108
- C1 -
-
2B9J
1
FUS3_YEAST
A:
[5-351]
----------------------------------------------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
-
H
K
P
T
G
E
I
V
A
I
K
K
I
--
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
-
P
D
--
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
--
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
----------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
------------------
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
--
M
Y
P
A
A
P
L
E
------------
K
------------
M
F
P
--------
R
----
V
N
--------
P
K
---
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
EP
I
P
-
P
---
S
--
F
F
E
F
-
D
HY
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
74.80
47%
-143
- C1 -
-
3MW1
1
MK14_HUMAN
A:
[17-347]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
-----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
74.79
48%
-107
- C1 -
-
2B9I
1
FUS3_YEAST
A:
[5-351]
----------------------------------------------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
-
H
K
P
T
G
E
I
V
A
I
K
K
I
--
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
-
P
D
--
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
--
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
E
---------
V
E
F
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
------------------
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
--
M
Y
P
A
A
P
L
E
------------
K
------------
M
F
P
--------
R
----
V
N
--------
P
K
---
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
EP
I
P
-
P
---
S
--
F
F
E
F
-
D
HY
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
74.70
46%
-144
- C1 -
-
6SOU
2
MK14_MOUSE
A:
[39-369]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
---
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
561
HHSearch
74.63
46%
-140
- C1 -
-
6SP9
5
MK14_MOUSE
A:
[14-350]
-------------------------------------------
L
N
K
T
I
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
-
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
-
A
R
H
T
-------------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
V
A
--
D
--
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
74.62
46%
-136
- C1 -
-
6SFJ
1
MK14_HUMAN
A:
[19-349]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
74.57
47%
-146
- C1 -
-
2RG5
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
----
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
74.57
47%
-146
- C1 -
-
3MVM
1
MK14_HUMAN
B:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
----
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
74.54
47%
-141
- C1 -
-
4KIP
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
74.53
46%
-142
- C1 -
-
3HA8
1
MK14_HUMAN
A:
[37-367]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
-------
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
74.46
47%
-143
- C1 -
-
3LHJ
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--------------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
74.44
47%
-137
- C1 -
-
3FLN
1
MK14_HUMAN
C:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
K
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
----
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
74.41
47%
-146
- C1 -
-
3ZYA
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
-------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
74.40
46%
-141
- C1 -
-
6SFI
1
MK14_HUMAN
A:
[19-349]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
-----------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
74.37
49%
-101
- C1 -
-
2B9F
1
FUS3_YEAST
A:
[5-351]
----------------------------------------------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
-
H
K
P
T
G
E
I
V
A
I
K
K
I
--
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
-
P
D
--
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
--
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
----------
T
E
Y
V
A
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
------------------
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
--
M
Y
P
A
A
P
L
E
------------
K
------------
M
F
P
--------
R
----
V
N
--------
P
K
---
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
EP
I
P
-
P
---
S
--
F
F
E
F
-
D
HY
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
74.34
46%
-142
- C1 -
-
6SFO
2
MK14_HUMAN
A:
[19-349]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
---
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
74.26
46%
-148
- C1 -
-
3HUB
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
---------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
74.25
47%
-146
- C1 -
-
3HV5
3
MK14_HUMAN
B:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
74.23
47%
-142
- C1 -
-
3NWW
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
-----------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
74.19
47%
-149
- C1 -
-
3HV4
4
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
74.14
47%
-145
- C1 -
-
3MVM
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
-----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
-------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
74.13
46%
-142
- C1 -
-
6SOV
3
MK14_MOUSE
A:
[19-349]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
A
----------------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
74.10
46%
-139
- C1 -
-
2BAL
1
MK14_HUMAN
A:
[23-353]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
------------------
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
74.06
47%
-134
- C1 -
-
3QUD
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
----------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
74.04
46%
-132
- C1 -
-
3DT1
1
MK14_HUMAN
A:
[41-371]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
74.03
46%
-142
- C1 -
-
6SP9
5
MK14_MOUSE
A:
[19-349]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
-
A
R
H
T
-------------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
73.98
46%
-139
- C1 -
-
6SPL
4
MK14_MOUSE
A:
[19-349]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
A
----------------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
73.93
47%
-141
- C1 -
-
3C5U
2
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
73.88
47%
-139
- C1 -
-
3OCG
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
73.87
46%
-138
- C1 -
-
6ANL
1
MK14_HUMAN
A:
[23-353]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
A
------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
73.86
47%
-146
- C1 -
-
3FC1
1
MK14_HUMAN
X:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
------
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
----------------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
73.82
47%
-145
- C1 -
-
1ZZ2
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
73.80
46%
-144
- C1 -
-
3PG3
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
73.79
47%
-143
- C1 -
-
2RG6
2
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
-----------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
73.71
49%
-103
- C1 -
-
2F9G
1
FUS3_YEAST
A:
[5-351]
----------------------------------------------
I
V
Y
N
I
S
S
D
F
Q
L
K
S
L
L
G
E
G
A
Y
G
V
V
C
S
A
T
-
H
K
P
T
G
E
I
V
A
I
K
K
I
--
E
P
F
D
K
P
L
F
A
L
R
T
L
R
E
I
K
I
L
K
H
F
K
H
E
N
I
I
T
I
F
N
I
Q
R
-
P
D
--
S
F
E
N
F
N
E
V
Y
I
I
Q
E
L
M
Q
T
D
L
H
R
V
I
-
S
T
Q
M
L
S
D
D
H
I
Q
--
Y
F
I
Y
Q
T
L
R
A
V
K
V
L
H
G
S
N
V
I
H
R
D
L
K
P
S
N
L
L
I
N
S
N
C
D
L
K
V
C
D
F
G
L
A
R
I
I
D
---------------
T
R
W
Y
R
A
P
E
V
M
L
T
S
A
K
Y
S
R
A
M
D
V
W
S
C
G
C
I
L
A
E
L
F
L
R
R
P
I
F
P
G
R
D
Y
R
H
------------------
Q
L
L
L
I
F
G
I
I
G
T
P
H
S
D
N
D
L
R
C
I
E
S
P
R
A
R
E
Y
I
K
S
L
P
--
M
Y
P
A
A
P
L
E
------------
K
------------
M
F
P
--------
R
----
V
N
--------
P
K
---
G
I
D
L
L
Q
R
M
L
V
F
D
P
A
K
R
I
T
A
K
E
A
L
E
H
P
Y
L
Q
T
Y
H
D
P
N
D
E
P
E
G
EP
I
P
-
P
---
S
--
F
F
E
F
-
D
HY
K
E
A
L
T
T
K
D
L
K
K
L
I
W
N
E
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
73.65
47%
-136
- C1 -
-
4FA2
3
MK14_HUMAN
A:
[41-371]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
73.60
46%
-145
- C1 -
-
3CTQ
1
MK14_HUMAN
A:
[14-344]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
A
K
-
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
73.60
47%
-138
- C1 -
-
5OMG
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
73.59
47%
-139
- C1 -
-
3HUC
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
73.53
47%
-142
- C1 -
-
4EH2
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
73.53
46%
-146
- C1 -
-
3P5K
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
73.50
47%
-137
- C1 -
-
3BV3
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
-----------------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
73.50
47%
-136
- C1 -
-
4AA4
1
MK14_HUMAN
A:
[23-353]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
73.50
47%
-136
* C1 *
-
3KF7
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
73.48
47%
-142
- C1 -
-
4KIP
1
MK14_HUMAN
B:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
73.47
46%
-145
- C1 -
-
3ZSH
2
MK14_HUMAN
A:
[20-350]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
73.42
47%
-143
- C1 -
-
3HV4
3
MK14_HUMAN
B:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
73.34
46%
-139
- C1 -
-
6SFK
5
MK14_HUMAN
A:
[19-349]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
73.33
46%
-141
- C1 -
-
3ZS5
6
MK14_HUMAN
A:
[20-350]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
-------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
73.29
47%
-134
- C1 -
-
3MVL
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
-----------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
73.29
47%
-151
- C1 -
-
3S4Q
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
-----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
---
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
------------------
A
T
R
W
Y
R
A
P
E
I
M
-----
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
73.29
47%
-148
- C1 -
-
3HEG
1
MK14_HUMAN
A:
[14-344]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
----
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
------------------
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
73.25
47%
-142
- C1 -
-
3MVL
1
MK14_HUMAN
B:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
-----------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
73.26
47%
-136
- C1 -
-
4ZTH
3
MK14_HUMAN
A:
[41-371]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
73.25
46%
-143
- C1 -
-
6HWV
4
MK14_HUMAN
A:
[20-350]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
-------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
73.24
47%
-142
- C1 -
-
3UVR
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
-------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
------
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
73.19
47%
-140
- C1 -
-
3BV2
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
-----------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
73.18
47%
-133
- C1 -
-
4AAC
1
MK14_HUMAN
A:
[23-353]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
------
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
73.17
47%
-143
- C1 -
-
3HL7
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
73.12
47%
-145
- C1 -
-
4EH6
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
73.10
47%
-135
- C1 -
-
3ROC
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
73.08
47%
-133
- C1 -
-
3HP2
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
73.02
46%
-144
- C1 -
-
3P79
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
73.01
46%
-139
- C1 -
-
3O8P
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
G
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
72.95
46%
-143
- C1 -
-
3GCV
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
C
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
72.93
46%
-138
- C1 -
-
3OBJ
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
R
G
L
-------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
72.88
47%
-140
- C1 -
-
4F9Y
6
MK14_HUMAN
A:
[41-371]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
72.87
47%
-142
- C1 -
-
3HV6
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
----
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
--
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
72.87
46%
-144
- C1 -
-
3P78
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
72.82
46%
-146
- C1 -
-
3O8U
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
Y
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
72.82
47%
-139
- C1 -
-
4F9W
5
MK14_HUMAN
A:
[41-371]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
-------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
72.80
47%
-147
- C1 -
-
3LFA
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
72.78
47%
-144
- C1 -
-
2QD9
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
--
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
--------------------
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
72.76
47%
-134
- C1 -
-
3FI4
1
MK14_HUMAN
A:
[30-360]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
K
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
--------
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
72.71
47%
-139
- C1 -
-
4EH4
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
--
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
72.71
49%
-145
- C1 -
-
3GC9
1
MK11_HUMAN
A:
[36-354]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
Y
-
D
A
R
L
R
Q
K
V
A
V
K
K
L
-
S
R
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
T
-
S
I
E
D
F
S
E
V
Y
L
V
T
T
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
A
L
S
D
E
H
V
Q
--
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
N
E
D
S
E
L
R
I
L
D
F
G
L
A
------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
G
K
A
L
F
P
G
S
D
Y
I
D
------------------
Q
L
K
R
I
M
E
V
V
G
T
P
-
S
P
E
V
L
A
K
I
S
S
E
H
A
R
T
Y
I
Q
S
L
P
--
P
M
P
Q
K
D
L
S
------------
S
------------
I
F
R
--------
G
----
A
N
--------
P
L
---
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
Y
H
D
P
E
D
E
P
E
---
A
E
-
P
---
Y
--
D
E
S
V
-
E
--
A
K
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
72.65
46%
-141
- C1 -
-
3P7C
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
72.62
47%
-137
- C1 -
-
3HLL
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
72.63
46%
-143
- C1 -
-
5XYX
1
MK14_HUMAN
A:
[38-368]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
------
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
72.62
47%
-135
- C1 -
-
4EHV
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
72.57
46%
-137
- C1 -
-
3LFE
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
72.57
47%
-142
- C1 -
-
3UVP
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
72.43
46%
-144
- C1 -
-
4R3C
3
MK14_HUMAN
A:
[41-371]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
72.43
46%
-138
- C1 -
-
3NNX
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
--------
H
T
------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
72.40
46%
-144
- C1 -
-
3O8T
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
A
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
72.40
47%
-148
- C1 -
-
1ZYJ
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
72.40
46%
-143
- C1 -
-
6HWT
4
MK14_HUMAN
A:
[20-350]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
-
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
72.39
47%
-138
- C1 -
-
4EH3
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
-----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
72.35
47%
-141
- C1 -
-
5N65
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
72.33
46%
-142
- C1 -
-
3MPA
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
G
F
G
---------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
72.32
46%
-130
- C1 -
-
1YW2
1
MK14_MOUSE
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-
A
R
H
---------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
72.26
46%
-143
- C1 -
-
3P7B
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
72.24
46%
-135
- C1 -
-
6M95
1
MK14_HUMAN
A:
[46-376]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
72.23
47%
-125
- C1 -
-
3QUE
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
----------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
72.22
47%
-128
- C1 -
-
4L8M
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
--
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
-----------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
72.21
47%
-136
- C1 -
-
4EH7
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
72.18
47%
-143
- C1 -
-
4EH8
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
72.17
47%
-143
- C1 -
-
5MTX
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
----
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
72.16
47%
-153
- C1 -
-
3L8X
1
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
------
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
-
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
-----------------
A
T
R
W
Y
R
A
P
E
I
M
------
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
72.14
46%
-136
- C1 -
-
2GHM
1
MK14_MOUSE
A:
[14-344]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
-
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
72.11
46%
-137
- C1 -
-
3LFB
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
----
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
72.06
46%
-139
- C1 -
-
3GCS
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
---
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
---------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
72.05
46%
-139
- C1 -
-
3P7A
2
MK14_MOUSE
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
72.04
46%
-136
- C1 -
-
3GCQ
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
71.97
46%
-138
- C1 -
-
3HV3
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
71.97
47%
-146
- C1 -
-
3UVQ
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
71.89
46%
-137
- C1 -
-
3GCP
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
C
-------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
71.87
46%
-132
- C1 -
-
3IW5
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
-------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
71.89
47%
-145
- C1 -
-
3HEC
2
MK14_HUMAN
A:
[14-344]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
-----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
71.87
47%
-140
- C1 -
-
4TYH
1
MK14_MOUSE
B:
[13-343]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
---------------
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
-----
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
71.84
46%
-135
- C1 -
-
3IW7
4
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
-------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
71.82
47%
-137
- C1 -
-
3HV7
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
-----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
71.81
47%
-140
- C1 -
-
4AA0
1
MK14_HUMAN
A:
[23-353]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
--------
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
71.75
46%
-140
- C1 -
-
3LFF
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
71.74
47%
-131
- C1 -
-
2GTN
1
MK14_MOUSE
A:
[14-344]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
71.70
47%
-138
- C1 -
-
3K3I
3
MK14_HUMAN
A:
[16-346]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
-----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
71.67
47%
-127
- C1 -
-
2GTM
1
MK14_MOUSE
A:
[14-344]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
--------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
71.64
46%
-139
- C1 -
-
2GHL
1
MK14_MOUSE
A:
[14-344]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
-----------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
71.44
46%
-140
- C1 -
-
3ZSI
2
MK14_HUMAN
A:
[20-350]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
-----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
------
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
71.40
46%
-143
- C1 -
-
3OC1
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
G
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
71.40
47%
-144
- C1 -
-
5MTY
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
------
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
71.40
47%
-137
- C1 -
-
3K3J
2
MK14_HUMAN
A:
[20-350]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
--
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
-----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
71.36
46%
-134
- C1 -
-
4AA5
1
MK14_HUMAN
A:
[23-353]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
----------
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
71.36
46%
-136
- C1 -
-
3IW8
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
71.33
46%
-148
- C1 -
-
3GI3
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
------
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
-------------------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
71.32
46%
-131
- C1 -
-
2BAQ
1
MK14_HUMAN
A:
[23-353]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
I
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
---------
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
----------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
71.30
47%
-134
- C1 -
-
4EH9
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
71.29
47%
-139
- C1 -
-
2YIW
2
MK14_HUMAN
A:
[17-347]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
---------
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
-------------------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
71.26
46%
-139
- C1 -
-
6HWU
4
MK14_HUMAN
A:
[20-350]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
------
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
71.17
47%
-136
- C1 -
-
3HP5
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
-----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
71.13
46%
-127
- C1 -
-
3IW6
4
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
71.13
46%
-138
- C1 -
-
3LFC
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
----
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
71.03
46%
-135
- C1 -
-
1YWR
1
MK14_MOUSE
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
--
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
71.01
40%
-102
- C1 -
-
4X21
1
MK10_HUMAN
A:
[20-363]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
-------------------
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
PQI--------
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
70.97
47%
-138
- C1 -
-
5N66
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
557
HHSearch
70.89
40%
-145
- C1 -
-
1CM8
1
MK12_HUMAN
A:
[19-353]
----------------------------------------------
T
A
W
E
V
R
A
V
Y
R
D
L
Q
P
V
------
A
V
C
S
A
V
-
D
G
R
T
G
A
K
V
A
I
K
K
L
-
Y
R
P
F
Q
S
E
L
F
A
K
R
A
Y
R
E
L
R
L
L
K
H
M
R
H
E
N
V
I
G
L
L
D
V
F
T
-
P
D
E
-
T
L
D
D
F
T
D
F
Y
L
V
M
P
F
M
G
T
D
L
G
K
L
M
K
H
-
E
K
L
G
E
D
R
I
Q
--
F
L
V
Y
Q
M
L
K
G
L
R
Y
I
H
A
A
G
I
I
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
Q
A
D
S
E
-------
M
T
G
Y
V
V
T
R
W
Y
R
A
P
E
V
I
L
N
W
M
R
Y
T
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
I
T
G
K
T
L
F
K
G
S
D
H
L
D
------------------
Q
L
K
E
I
M
K
V
T
G
T
P
-
P
A
E
F
V
Q
R
L
Q
S
D
E
A
K
N
Y
M
K
G
L
P
--
E
L
E
K
K
D
F
A
------------
S
------------
I
L
T
--------
N
----
A
S
--------
P
L
---
A
V
N
L
L
E
K
M
L
V
L
D
A
E
Q
R
V
T
A
G
E
A
L
A
H
P
Y
F
E
S
L
H
------
Q
V
---
Q
-
K
---
Y
--
D
D
S
--------
R
T
L
D
E
W
K
R
V
T
Y
K
E
V
L
S
F
K
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
70.87
47%
-139
- C1 -
-
5TCO
3
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
----
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
--------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
-----------------------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
70.86
47%
-122
- C1 -
-
2BAJ
1
MK14_HUMAN
A:
[23-353]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
-----------
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
---
T
D
D
E
----
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
----
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
-
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
Blastp_CBE
70.81
40%
-103
- C1 -
-
3V6S
1
MK10_HUMAN
A:
[17-360]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
--
Q
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
R
T
A
G
T
S
-----
F
M
-----
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
PQI-----
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
70.81
46%
-138
- C1 -
-
6M9L
1
MK14_HUMAN
A:
[46-376]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
---
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
---------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
Blastp_CBE
70.70
40%
-107
- C1 -
-
3V6S
1
MK10_HUMAN
B:
[17-360]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
--
Q
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
------------------
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
PQI-----
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
70.70
40%
-99
- C1 -
-
6EQ9
4
MK10_HUMAN
A:
[20-363]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
R
T
A
G
T
S
-----
F
M
-----
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
PQI
Y
--
D
K
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
70.70
46%
-142
- C1 -
-
6OHD
1
?
A:
[46-376]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
------
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
G
L
A
R
-----------------
A
T
R
W
Y
R
A
P
E
I
M
L
---
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
70.62
40%
-105
- C1 -
-
4Y5H
1
MK10_HUMAN
A:
[19-362]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
R
T
A
--
S
-----
F
M
M
T
P
Y
V
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
P-------
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
70.62
46%
-140
- C1 -
-
3HVC
2
MK14_HUMAN
A:
[20-350]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
70.59
47%
-146
- C1 -
-
5ML5
4
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--------
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
70.56
46%
-139
- C1 -
-
3OBG
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
G
G
L
-------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
70.54
47%
-132
- C1 -
-
4DLJ
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
-
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
---------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
70.51
47%
-140
- C1 -
-
5TBE
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
---
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
--------------------
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
--
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
70.38
41%
-101
- C1 -
-
3ELJ
1
MK08_HUMAN
A:
[22-368]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
I
L
E
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
G
L
L
N
V
F
T
-
P
Q
K
-
S
L
E
E
F
Q
D
V
Y
I
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
------
S
-----
F
M
M
T
P
Y
V
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
L
W
S
V
G
C
I
M
G
E
M
V
C
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
T
Y
V
E
N
R
P
--
K
Y
A
G
Y
S
F
E
------------
K
------------
L
F
P
--------
D
VLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
A
S
K
R
I
S
V
D
E
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
-
S
E
A
E
A
--
P
P
-
P
---
K
IP--------
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
M
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
70.37
48%
-127
- C1 -
-
3GC8
1
MK11_HUMAN
A:
[36-354]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
Y
-
D
A
R
L
R
Q
K
V
A
V
K
K
L
-
S
R
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
T
-
S
I
E
D
F
S
E
V
Y
L
V
T
T
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
A
L
S
D
E
H
V
Q
--
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
N
E
D
S
E
L
R
I
L
D
F
G
L
A
R
-----
Q
A
D
E
E
--
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
G
K
A
L
F
P
G
S
D
Y
I
D
------------------
Q
L
K
R
I
M
E
V
V
G
T
P
-
S
P
E
V
L
A
K
I
S
S
E
H
A
R
T
Y
I
Q
S
L
P
--
P
M
P
Q
K
D
L
S
------------
S
------------
I
F
R
--------
G
----
A
N
--------
P
L
---
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
Y
H
D
P
E
D
E
P
E
---
A
E
-
P
---
Y
--
D
E
S
V
-
E
--
A
K
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
70.34
47%
-138
- C1 -
-
2BAK
1
MK14_HUMAN
A:
[23-353]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
70.34
47%
-138
- C1 -
-
4A9Y
1
MK14_HUMAN
A:
[23-353]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
----
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
70.28
46%
-141
- C1 -
-
2PUU
1
MK14_MOUSE
A:
[14-344]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
------
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
K
C
A
K
-
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
-------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
70.19
40%
-107
- C1 -
-
6EQ9
4
MK10_HUMAN
B:
[20-363]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
-------------------
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
PQ-------------
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
70.18
41%
-104
- C1 -
-
4L7F
1
MK08_HUMAN
A:
[13-363]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
I
L
E
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
G
L
L
N
V
F
T
-
P
Q
K
-
S
L
E
E
F
Q
D
V
Y
I
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
------------------
V
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
L
W
S
V
G
C
I
M
G
E
M
V
C
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
T
Y
V
E
N
R
P
--
K
Y
A
G
Y
S
F
E
------------
K
------------
L
F
P
--------
D
VLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
A
S
K
R
I
S
V
D
E
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
-
S
E
A
E
A
--
P
P
-
P
---
K
IP
D
K
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
M
D
W
---
R
K
G
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
70.17
40%
-104
- C1 -
-
4X21
1
MK10_HUMAN
B:
[20-363]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
------------------
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
PQI--------
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
70.10
41%
-100
- C1 -
-
4AWI
1
MK08_HUMAN
A:
[22-368]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
I
L
E
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
G
L
L
N
V
F
T
-
P
Q
K
-
S
L
E
E
F
Q
D
V
Y
I
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
-----
S
-----
F
M
M
T
P
Y
V
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
L
W
S
V
G
C
I
M
G
E
M
V
C
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
T
Y
V
E
N
R
P
--
K
Y
A
G
Y
S
F
E
------------
K
------------
L
F
P
--------
D
VLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
A
S
K
R
I
S
V
D
E
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
-
S
E
A
E
A
--
P
P
-
P
---
K
IP
D
K
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
M
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
70.09
46%
-140
- C1 -
-
5O90
1
MK14_MOUSE
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
H
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
----------------
Y
V
A
G
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
----------
S
L
A
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
70.06
46%
-138
- C1 -
-
3L8S
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
--------------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
70.02
46%
-143
- C1 -
-
2FST
3
MK14_HUMAN
X:
[25-355]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
------
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
69.96
47%
-141
- C1 -
-
5OMH
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
----
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
------
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
69.95
40%
-110
- C1 -
-
4W4Y
1
MK10_HUMAN
A:
[19-362]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
R
T
A
G
T
S
-----
F
M
M
T
P
Y
V
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
P--------
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
69.91
46%
-136
- C1 -
-
2EWA
1
MK14_MOUSE
A:
[37-367]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
------
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
---------------------
T
R
W
Y
R
A
P
E
I
M
L
N
-
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
69.85
47%
-131
- C1 -
-
1KV1
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-----
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
--------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
69.82
41%
-98
- C1 -
-
4QTD
25
MK08_HUMAN
A:
[18-364]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
I
L
E
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
G
L
L
N
V
F
T
-
P
Q
K
-
S
L
E
E
F
Q
D
V
Y
I
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
R
---
T
S
-----
F
M
M
T
P
Y
V
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
L
W
S
V
G
C
I
M
G
E
M
V
C
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
T
Y
V
E
N
R
P
--
K
Y
A
G
Y
S
F
E
------------
K
------------
L
F
P
--------
D
VLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
A
S
K
R
I
S
V
D
E
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
-
S
E
A
E
A
--
P
P
-
P
---
K
IP
D
K
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
M
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
69.77
47%
-138
- C1 -
-
4EH5
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
--
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
------
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
----------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
69.73
41%
-101
- C1 -
-
3PZE
1
MK08_HUMAN
A:
[11-356]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
I
L
E
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
G
L
L
N
V
F
T
-
P
Q
K
-
S
L
E
E
F
Q
D
V
Y
I
V
M
E
L
M
D
A
N
L
C
Q
V
I
--
Q
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
------
S
-----
F
M
M
T
---
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
L
W
S
V
G
C
I
M
G
E
M
V
C
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
T
Y
V
E
N
R
P
--
K
Y
A
G
Y
S
F
E
------------
K
------------
L
F
P
--------
D
VLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
A
S
K
R
I
S
V
D
E
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
-
S
E
A
E
A
--
P
P
-
P
---
K
IP
D
K
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
M
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
69.68
46%
-130
- C1 -
-
3LFD
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
-----
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
S
E
L
K
I
L
D
F
---------------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
L
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
69.60
47%
-139
- C1 -
-
2YIS
2
MK14_HUMAN
A:
[17-347]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
---
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
---------
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
-------------------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
69.18
46%
-132
- C1 -
-
3OHT
3
?
B:
[47-377]
------------------------------------------------
W
E
V
P
E
R
Y
Q
T
L
S
P
V
G
S
G
A
Y
G
S
V
C
S
S
Y
-
D
V
K
S
G
L
K
I
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
T
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
------------------------
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
M
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
N
------------------
Q
L
Q
Q
I
M
R
L
T
G
T
P
-
P
A
S
V
I
S
R
M
P
S
H
E
A
R
N
Y
I
N
S
L
P
--
Q
M
P
K
R
N
F
A
------------
D
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
T
D
K
R
I
T
A
S
E
A
L
A
H
P
Y
F
S
Q
Y
H
D
P
D
D
E
P
E
---
S
E
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
Q
L
E
I
E
E
W
K
R
L
T
Y
E
E
V
C
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
69.11
47%
-132
- C1 -
-
1KV2
1
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
---------
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
----------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
69.04
51%
-36
- C1 -
-
5HD7
1
MK01_RAT
A:
[23-359]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
D
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
69.02
49%
-130
- C1 -
-
3GC9
1
MK11_HUMAN
B:
[36-354]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
Y
-
D
A
R
L
R
Q
K
V
A
V
K
K
L
-
S
R
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
T
-
S
I
E
D
F
S
E
V
Y
L
V
T
T
L
M
G
A
D
L
N
N
I
V
-
K
S
Q
A
L
S
D
E
H
V
Q
--
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
N
E
D
S
E
L
R
I
L
D
F
G
L
A
R
----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
G
K
A
L
F
P
G
S
D
Y
I
D
------------------
Q
L
K
R
I
M
E
V
V
G
T
P
-
S
P
E
V
L
A
K
I
S
S
E
H
A
R
T
Y
I
Q
S
L
P
--
P
M
P
Q
K
D
L
S
------------
S
------------
I
F
R
--------
G
----
A
N
--------
P
L
---
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
Y
H
D
P
E
D
E
P
E
---
A
E
-
P
---
Y
--
D
E
S
V
-
E
--
A
K
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
68.97
51%
-50
- C1 -
-
4QPA
1
MK01_HUMAN
B:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
--
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
-
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
68.79
45%
-133
- C1 -
-
5EKO
1
MK13_HUMAN
A:
[50-368]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
I
-
D
K
R
S
G
E
K
V
A
I
K
K
L
-
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
Q
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
S
-
S
L
R
N
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
--
G
M
E
F
S
E
E
K
I
Q
--
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
----------------
G
Y
V
V
T
R
W
Y
R
A
P
E
V
I
L
S
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
------------------
Q
L
T
Q
I
L
K
V
T
G
V
P
-
G
T
E
F
V
Q
K
L
N
D
K
A
A
K
S
Y
I
Q
S
L
P
--
Q
T
P
R
K
D
F
T
------------
Q
------------
L
F
P
--------
R
----
A
S
--------
P
Q
---
A
A
D
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
P
E
E
E
T
E
A
--
Q
Q
-
P
---
F
--
D
D
S
L
-
E
--
H
E
K
L
T
V
D
E
W
K
Q
H
I
Y
K
E
I
V
N
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
68.79
51%
-41
- C1 -
-
2OJJ
1
MK01_HUMAN
A:
[38-374]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
68.78
51%
-38
- C1 -
-
2OJG
1
MK01_HUMAN
A:
[39-374]
------------------------------------------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
---
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
Blastp_CBE
68.75
51%
-35
- C1 -
-
6G54
14
MK01_HUMAN
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
68.67
51%
-40
- C1 -
-
4S33
1
MK01_RAT
A:
[16-352]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
S
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
68.56
46%
-135
- C1 -
-
3OHT
3
?
A:
[47-377]
------------------------------------------------
W
E
V
P
E
R
Y
Q
T
L
S
P
V
G
S
G
A
Y
G
S
V
C
S
S
Y
-
D
V
K
S
G
L
K
I
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
T
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
------------------------
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
M
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
N
------------------
Q
L
Q
Q
I
M
R
L
T
G
T
P
-
P
A
S
V
I
S
R
M
P
S
H
E
A
R
N
Y
I
N
S
L
P
--
Q
M
P
K
R
N
F
A
------------
D
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
T
D
K
R
I
T
A
S
E
A
L
A
H
P
Y
F
S
Q
Y
H
D
P
D
D
E
P
E
---
S
E
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
Q
L
E
I
E
E
W
K
R
L
T
Y
E
E
V
C
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
68.58
51%
-35
- C1 -
-
5HD4
4
MK01_RAT
A:
[23-359]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
68.57
51%
-38
- C1 -
-
4S32
1
MK01_RAT
A:
[16-352]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
68.56
51%
-36
- C1 -
-
5KE0
1
MK01_RAT
A:
[24-360]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
68.48
39%
-145
- C1 -
-
1CM8
1
MK12_HUMAN
B:
[27-351]
------------------------------------------------------
Y
R
D
L
Q
P
V
------
A
V
C
S
A
V
-
D
G
R
T
G
A
K
V
A
I
K
K
L
-
Y
R
P
F
Q
S
E
L
F
A
K
R
A
Y
R
E
L
R
L
L
K
H
M
R
H
E
N
V
I
G
L
L
D
V
F
T
-
P
D
E
-
T
L
D
D
F
T
D
F
Y
L
V
M
P
F
M
G
T
D
L
G
K
L
M
-
K
H
E
K
L
G
E
D
R
I
Q
--
F
L
V
Y
Q
M
L
K
G
L
R
Y
I
H
A
A
G
I
I
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
Q
A
D
S
E
M
G
G
Y
-------
V
V
T
R
W
Y
R
A
P
E
V
I
L
N
W
M
R
Y
T
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
I
T
G
K
T
L
F
K
G
S
D
H
L
D
------------------
Q
L
K
E
I
M
K
V
T
G
T
P
-
P
A
E
F
V
Q
R
L
Q
S
D
E
A
K
N
Y
M
K
G
L
P
--
E
L
E
K
K
D
F
A
------------
S
------------
I
L
T
--------
N
----
A
S
--------
P
L
---
A
V
N
L
L
E
K
M
L
V
L
D
A
E
Q
R
V
T
A
G
E
A
L
A
H
P
Y
F
E
S
L
H
------
Q
V
---
Q
-
K
---
Y
--
D
D
S
--------
R
T
L
D
E
W
K
R
V
T
Y
K
E
V
L
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
68.47
51%
-39
- C1 -
-
2Y9Q
1
MK01_HUMAN
A:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
68.33
39%
-146
- C1 -
-
1CM8
1
MK12_HUMAN
A:
[27-351]
------------------------------------------------------
Y
R
D
L
Q
P
V
------
A
V
C
S
A
V
-
D
G
R
T
G
A
K
V
A
I
K
K
L
-
Y
R
P
F
Q
S
E
L
F
A
K
R
A
Y
R
E
L
R
L
L
K
H
M
R
H
E
N
V
I
G
L
L
D
V
F
T
-
P
D
E
-
T
L
D
D
F
T
D
F
Y
L
V
M
P
F
M
G
T
D
L
G
K
L
M
-
K
H
E
K
L
G
E
D
R
I
Q
--
F
L
V
Y
Q
M
L
K
G
L
R
Y
I
H
A
A
G
I
I
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
Q
A
D
S
E
M
G
G
Y
-------
V
V
T
R
W
Y
R
A
P
E
V
I
L
N
W
M
R
Y
T
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
I
T
G
K
T
L
F
K
G
S
D
H
L
D
------------------
Q
L
K
E
I
M
K
V
T
G
T
P
-
P
A
E
F
V
Q
R
L
Q
S
D
E
A
K
N
Y
M
K
G
L
P
--
E
L
E
K
K
D
F
A
------------
S
------------
I
L
T
--------
N
----
A
S
--------
P
L
---
A
V
N
L
L
E
K
M
L
V
L
D
A
E
Q
R
V
T
A
G
E
A
L
A
H
P
Y
F
E
S
L
H
------
Q
V
---
Q
-
K
---
Y
--
D
D
S
--------
R
T
L
D
E
W
K
R
V
T
Y
K
E
V
L
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
68.27
45%
-127
- C1 -
-
4EYJ
1
MK13_HUMAN
A:
[50-368]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
I
-
D
K
R
S
G
E
K
V
A
I
K
K
L
-
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
Q
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
S
-
S
L
R
N
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
--
G
M
E
F
S
E
E
K
I
Q
--
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
-------------------
V
T
R
W
Y
R
A
P
E
V
I
L
S
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
------------------
Q
L
T
Q
I
L
K
V
T
G
V
P
-
G
T
E
F
V
Q
K
L
N
D
K
A
A
K
S
Y
I
Q
S
L
P
--
Q
T
P
R
K
D
F
T
------------
Q
------------
L
F
P
--------
R
----
A
S
--------
P
Q
---
A
A
D
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
P
E
E
E
T
E
A
--
Q
Q
-
P
---
F
--
D
D
S
L
-
E
--
H
E
K
L
T
V
D
E
W
K
Q
H
I
Y
K
E
I
V
N
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
68.26
51%
-35
- C1 -
-
3ERK
1
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
68.24
51%
-43
- C1 -
-
5NHP
1
MK01_HUMAN
A:
[37-373]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
----------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
68.21
51%
-41
- C1 -
-
6SLG
5
?
A:
[37-373]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
----------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
68.15
45%
-131
- C1 -
-
4EYM
1
MK13_HUMAN
A:
[50-368]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
I
-
D
K
R
S
G
E
K
V
A
I
K
K
L
-
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
Q
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
S
-
S
L
R
N
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
--
G
M
E
F
S
E
E
K
I
Q
--
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
-----------------
Y
V
V
T
R
W
Y
R
A
P
E
V
I
L
S
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
------------------
Q
L
T
Q
I
L
K
V
T
G
V
P
-
G
T
E
F
V
Q
K
L
N
D
K
A
A
K
S
Y
I
Q
S
L
P
--
Q
T
P
R
K
D
F
T
------------
Q
------------
L
F
P
--------
R
----
A
S
--------
P
Q
---
A
A
D
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
P
E
E
E
T
E
A
--
Q
Q
-
P
---
F
--
D
D
S
L
-
E
--
H
E
K
L
T
V
D
E
W
K
Q
H
I
Y
K
E
I
V
N
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
68.11
51%
-39
- C1 -
-
5NHL
1
MK01_HUMAN
A:
[37-373]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
68.06
51%
-38
- C1 -
-
2OJI
1
MK01_HUMAN
A:
[38-374]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
68.04
40%
-100
- C1 -
-
3PTG
1
MK10_HUMAN
A:
[17-360]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
------------------
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
-HNKLKA--
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
PQI
Y
--
D
K
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
68.01
51%
-34
- C1 -
-
4QYY
1
MK01_RAT
A:
[23-359]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
-------
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
67.97
48%
-122
- C1 -
-
3GC8
1
MK11_HUMAN
B:
[36-354]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
Y
-
D
A
R
L
R
Q
K
V
A
V
K
K
L
-
S
R
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
T
-
S
I
E
D
F
S
E
V
Y
L
V
T
T
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
A
L
S
D
E
H
V
Q
--
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
N
E
D
S
E
L
R
I
L
D
F
G
L
A
R
-----
Q
A
D
E
E
--
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
G
K
A
L
F
P
G
S
D
Y
I
D
------------------
Q
L
K
R
I
M
E
V
V
G
T
P
-
S
P
E
V
L
A
K
I
S
S
E
H
A
R
T
Y
I
Q
S
L
P
--
P
M
P
Q
K
D
L
S
------------
S
------------
I
F
R
--------
G
----
A
N
--------
P
L
---
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
Y
H
D
P
E
D
E
P
E
---
A
E
-
P
---
Y
--
D
E
S
V
-
E
--
A
K
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
564
HHSearch
67.94
36%
-92
- C1 -
-
3N9X
2
?
A:
[22-409]
------------------------------------------------
V
H
V
P
D
N
Y
I
I
K
H
L
I
G
R
G
S
Y
G
Y
V
Y
L
A
Y
-
D
K
N
T
E
K
N
V
A
I
K
K
V
-
N
R
M
F
E
D
L
I
D
C
K
R
I
L
R
E
I
T
I
L
N
R
L
K
S
D
Y
I
I
R
L
Y
D
L
I
I
-
P
D
D
--
L
L
K
F
D
E
L
Y
I
V
L
E
I
A
D
S
D
L
K
K
L
F
K
T
P
I
F
L
T
E
E
H
I
K
--
T
I
L
Y
N
L
L
L
G
E
N
F
I
H
E
S
G
I
I
H
R
D
L
K
P
A
N
C
L
L
N
Q
D
C
S
V
K
V
C
D
F
G
L
A
R
T
I
-------------
H
V
V
T
R
W
Y
R
A
P
E
L
I
L
L
Q
E
N
Y
T
K
S
I
D
I
W
S
T
G
C
I
F
A
E
L
L
N
M
L
Q
S
H
I
N
D
P
T
N
R
FPLFPGSSCFPHEKSNRD
Q
L
N
I
I
F
N
I
I
G
T
P
-
T
E
D
D
L
K
N
I
N
K
P
E
V
I
K
Y
I
K
L
F
P
--
H
R
K
P
I
N
L
K
------------
Q
------------
K
Y
P
--------
S
----
I
S
--------
D
D
---
G
I
N
L
L
E
S
M
L
K
F
N
P
N
K
R
I
T
I
D
Q
A
L
D
H
P
Y
L
K
D
V
R
K
K
K
L
E
-----
T
K
-
K
---
I
--
I
L
P
F
D
D
--
W
M
V
L
S
E
T
Q
L
R
Y
I
F
L
K
E
V
Q
S
F
H
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
67.91
51%
-39
- C1 -
-
5NHV
1
MK01_HUMAN
A:
[37-373]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
67.87
51%
-35
- C1 -
-
1WZY
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
67.86
51%
-37
- C1 -
-
4QTE
22
MK01_HUMAN
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
67.80
51%
-38
- C1 -
-
1TVO
1
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
67.79
51%
-37
- C1 -
-
5U6I
1
MK01_RAT
A:
[24-360]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
-
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
67.76
51%
-35
- C1 -
-
4S34
1
MK01_RAT
A:
[16-352]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
A
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
------
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
67.65
40%
-102
- C1 -
-
4U79
1
MK10_HUMAN
A:
[17-360]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
--
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
--
Q
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
R
T
----------------
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
---------
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
67.67
51%
-34
- C1 -
-
5NHJ
1
MK01_HUMAN
A:
[37-373]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
67.63
45%
-135
- C1 -
-
5EKN
1
MK13_HUMAN
A:
[50-368]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
I
-
D
K
R
S
G
E
K
V
A
I
K
K
L
-
S
R
P
F
Q
S
E
I
F
A
K
R
A
Y
R
E
L
L
L
L
K
H
M
Q
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
S
-
S
L
R
N
F
Y
D
F
Y
L
V
M
P
F
M
Q
T
D
L
Q
K
I
M
--
G
M
E
F
S
E
E
K
I
Q
--
Y
L
V
Y
Q
M
L
K
G
L
K
Y
I
H
S
A
G
V
V
H
R
D
L
K
P
G
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
---------------------
V
T
R
W
Y
R
A
P
E
V
I
L
S
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
M
L
T
G
K
T
L
F
K
G
K
D
Y
L
D
------------------
Q
L
T
Q
I
L
K
V
T
G
V
P
-
G
T
E
F
V
Q
K
L
N
D
K
A
A
K
S
Y
I
Q
S
L
P
--
Q
T
P
R
K
D
F
T
------------
Q
------------
L
F
P
--------
R
----
A
S
--------
P
Q
---
A
A
D
L
L
E
K
M
L
E
L
D
V
D
K
R
L
T
A
A
Q
A
L
T
H
P
F
F
E
P
F
R
D
P
E
E
E
T
E
A
--
Q
Q
-
P
---
F
--
D
D
S
L
-
E
--
H
E
K
L
T
V
D
E
W
K
Q
H
I
Y
K
E
I
V
N
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
67.65
50%
-41
- C1 -
-
4XRL
1
MK01_RAT
A:
[8-344]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
A
A
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
------------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
67.63
51%
-37
- C1 -
-
5NHH
1
MK01_HUMAN
A:
[37-373]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
67.62
50%
-37
- C1 -
-
6OPK
1
MK01_RAT
A:
[10-346]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
E
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
67.62
51%
-37
- C1 -
-
5NHO
1
MK01_HUMAN
A:
[37-373]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
---
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
559
HHSearch
67.59
41%
-95
- C1 -
-
2XRW
3
MK08_HUMAN
A:
[19-366]
----------------------------------------------
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
I
L
E
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
G
L
L
N
V
F
T
-
P
Q
K
-
S
L
E
E
F
Q
D
V
Y
I
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
M
--
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
---------------------
R
Y
Y
R
A
P
E
V
I
L
G
-
M
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
I
K
G
G
V
L
F
P
G
T
D
H
I
D
------------------
Q
W
N
K
V
I
E
-
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
T
Y
V
E
N
R
P
--
K
Y
A
G
Y
S
F
E
KLFPDVLFPADS
E
------------
H
N
K
--------
L
----
K
A
--------
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
A
S
K
R
I
S
V
D
E
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
S
E
A
E
A
P
--
P
P
K
I
---
P
--
D
K
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
M
D
L
E
H
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
67.51
51%
-39
- C1 -
-
4ERK
1
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
67.38
40%
-117
- C1 -
-
4W4X
1
MK10_HUMAN
A:
[19-362]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
R
T
A
G
T
S
-----
F
M
M
T
P
Y
V
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
---------------------
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
553
HHSearch
67.34
40%
-101
- C1 -
-
1JNK
1
MK10_HUMAN
A:
[55-400]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
M
--
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
-----
S
F
-----
M
M
T
P
Y
V
V
T
R
Y
Y
R
A
P
E
V
I
L
G
-
M
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
-
T
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
LFPDSLFPADSE
H
N
K
--------
L
----
K
A
--------
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
A
P
--
P
P
----------
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
M
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
67.30
51%
-35
- C1 -
-
5BUI
1
MK01_HUMAN
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
----------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
67.28
51%
-38
- C1 -
-
3I60
1
MK01_HUMAN
A:
[38-374]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
-------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
67.26
50%
-34
- C1 -
-
6OPG
1
MK01_HUMAN
A:
[12-348]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
E
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
67.25
51%
-42
- C1 -
-
4QP1
2
MK01_HUMAN
A:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
-----------
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
67.16
50%
-31
- C1 -
-
5V62
7
MK01_HUMAN
A:
[9-345]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
E
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
66.96
51%
-36
- C1 -
-
4FMQ
1
MK01_HUMAN
A:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
66.93
40%
-115
- C1 -
-
6EKD
2
MK10_HUMAN
A:
[20-363]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
-------------------
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
------------------------
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
66.91
51%
-37
- C1 -
-
1GOL
1
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
R
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
66.90
50%
-31
- C1 -
-
6OPH
1
MK01_HUMAN
A:
[12-348]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
E
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
66.89
51%
-40
- C1 -
-
3TEI
1
MK01_HUMAN
A:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
66.84
51%
-35
- C1 -
-
4N4S
1
MK01_RAT
A:
[17-353]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
A
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
L
D
F
G
L
A
R
-
V
A
D
P
D
-------
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
66.76
50%
-33
- C1 -
-
5V60
7
MK01_HUMAN
A:
[14-350]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
E
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
66.75
51%
-43
- C1 -
-
6DCG
1
MK01_RAT
A:
[24-360]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
-----
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
-------------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
66.73
51%
-46
- C1 -
-
2Z7L
4
MK01_RAT
A:
[24-360]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
---
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
-------------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
66.70
51%
-40
- C1 -
-
4H3P
1
MK01_HUMAN
D:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-----------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
66.68
50%
-47
- C1 -
-
1PME
1
MK01_HUMAN
A:
[38-374]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
---
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
L
V
T
H
L
M
G
A
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
-------------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
66.55
51%
-40
- C1 -
-
4XJ0
1
MK01_HUMAN
A:
[7-343]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
---
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
66.54
51%
-36
- C1 -
-
5K4I
3
MK01_HUMAN
A:
[10-346]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
--------------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
66.41
51%
-39
- C1 -
-
4H3Q
1
MK01_HUMAN
A:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
S
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
G
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
66.37
40%
-113
- C1 -
-
4W4V
1
MK10_HUMAN
A:
[19-362]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
A
R
T
A
G
T
S
-----
F
M
M
T
P
Y
V
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
---------------------
Q
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
66.34
51%
-38
- C1 -
-
4O6E
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
-----------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
----
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
Blastp_CBE
66.26
40%
-100
- C1 -
-
3RTP
1
MK10_HUMAN
A:
[17-360]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
---
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
--------------------
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
P--------
L
-
D
--
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
66.23
50%
-29
- C1 -
-
5V61
5
MK01_HUMAN
A:
[14-350]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
E
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
66.18
51%
-38
- C1 -
-
4N4S
1
MK01_RAT
B:
[17-353]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
A
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
L
D
F
G
L
A
R
-
V
A
D
P
------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
66.16
40%
-102
- C1 -
-
3OY1
1
MK10_HUMAN
A:
[16-359]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
---
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
L
-------------------
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP
A
D
SEHNKLKA
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
E
----
A
P
-
P
--------------
E
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.09
51%
-34
- C1 -
-
4H3P
1
MK01_HUMAN
A:
[20-356]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
A
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
-------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
A
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
66.05
51%
-44
- C1 -
-
4QP2
2
MK01_HUMAN
A:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
------
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
66.04
51%
-42
- C1 -
-
4QP1
2
MK01_HUMAN
B:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
-
L
K
A
-
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
66.00
51%
-39
- C1 -
-
4QP8
1
MK01_HUMAN
B:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
--------
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
65.90
51%
-38
- C1 -
-
5BUJ
1
MK01_HUMAN
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
65
Blastp_CBE
65.87
51%
-37
- C1 -
-
4QTA
9
MK01_HUMAN
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
--------------
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
65.86
51%
-37
- C1 -
-
4QP7
1
MK01_HUMAN
A:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
--------
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
65.78
51%
-44
- C1 -
-
4QP6
2
MK01_HUMAN
A:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
65.61
40%
-110
- C1 -
-
3OXI
1
MK10_HUMAN
A:
[16-359]
---------------------------------------------
D
S
T
F
T
V
L
K
R
Y
Q
N
L
K
P
I
G
S
G
A
Q
G
I
V
C
A
A
Y
-
D
A
V
L
D
R
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
Q
T
H
A
K
R
A
Y
R
E
L
V
L
M
K
C
V
N
H
K
N
I
I
S
L
L
N
V
F
T
-
P
Q
K
-
T
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
Q
--
M
E
L
D
H
E
R
M
S
--
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
S
D
C
T
L
K
I
L
D
F
G
--------------------
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
K
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
V
R
H
K
I
L
F
P
G
R
D
Y
I
D
------------------
Q
W
N
K
V
I
E
Q
L
G
T
P
-
C
P
E
F
M
K
K
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
K
Y
A
G
L
T
F
P
------------
K
------------
L
F
P
--------
D
SLFP--HNKLKA--
S
Q
---
A
R
D
L
L
S
K
M
L
V
I
D
P
A
K
R
I
S
V
D
D
A
L
Q
H
P
Y
I
N
V
W
Y
D
P
A
E
V
------------------------
R
E
H
T
I
E
E
W
K
E
L
I
Y
K
E
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
65.37
51%
-38
- C1 -
-
4I5H
1
MK01_RAT
A:
[17-353]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
A
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
L
D
F
G
L
A
R
-
V
A
D
P
-------
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
---------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
65.34
51%
-38
- C1 -
-
4FV6
2
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
--------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
65.33
51%
-35
- C1 -
-
4QP9
1
MK01_HUMAN
A:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
--------
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
---
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
65.25
51%
-42
- C1 -
-
6CPW
1
MK01_RAT
A:
[24-360]
-----------------------------------------------
V
F
D
V
--
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
-----
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
----------
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
65.13
50%
-48
- C1 -
-
6OPI
1
MK01_HUMAN
A:
[12-348]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
------------
T
R
W
Y
R
A
P
E
I
M
L
N
-----
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
-------
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
65.13
51%
-37
- C1 -
-
4QP4
1
MK01_HUMAN
A:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
--------
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
65.02
51%
-40
- C1 -
-
5BVD
1
MK01_HUMAN
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
----------------
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
64.89
51%
-38
- C1 -
-
3I5Z
1
MK01_HUMAN
A:
[38-374]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
--------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
-----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
64.88
51%
-39
- C1 -
-
4XJ0
1
MK01_HUMAN
B:
[7-343]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
-------
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
64.49
51%
-37
- C1 -
-
5BUE
1
MK01_HUMAN
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
----------------
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
59
Blastp_CBE
64.25
51%
-40
- C1 -
-
4QP7
1
MK01_HUMAN
B:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
-----------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
63.98
51%
-40
- C1 -
-
4QP3
1
MK01_HUMAN
A:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
------
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
---
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
63.53
51%
-40
- C1 -
-
4QP8
1
MK01_HUMAN
A:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
-----------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
63.34
51%
-35
- C1 -
-
4QP4
1
MK01_HUMAN
B:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
-----------
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
63.19
51%
-35
- C1 -
-
5BVE
1
MK01_HUMAN
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
----------------
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
62.80
40%
-39
- C1 -
-
4O2Z
1
?
A:
[41-376]
------------------------------------------------
F
E
V
P
S
K
Y
T
L
L
K
I
L
G
M
G
A
Y
G
I
A
C
S
C
L
-
D
G
D
T
G
E
K
V
S
I
K
K
C
-
R
D
V
F
R
D
V
E
D
G
K
R
V
L
R
E
I
D
M
M
R
F
F
H
H
E
N
L
L
N
V
V
N
I
L
P
-
P
L
K
R
E
Y
H
S
F
E
D
V
Y
V
V
T
P
L
M
D
V
D
M
N
V
V
L
R
S
R
Q
V
L
E
E
S
H
M
Q
--
Y
F
V
Y
Q
I
L
R
G
L
K
Y
L
H
S
A
N
V
A
H
R
D
L
K
P
A
N
L
V
T
N
I
S
C
E
L
K
I
I
D
F
G
L
S
R
S
--
V
P
Y
S
E
----
L
T
D
Y
V
I
T
R
W
Y
R
P
P
E
L
L
L
E
N
T
N
Y
S
T
A
V
D
I
W
S
V
G
C
I
F
A
E
M
Y
N
R
K
P
V
F
P
G
R
N
T
M
D
------------------
Q
L
R
M
I
A
Q
H
I
G
K
P
-
P
A
S
I
V
E
H
------
R
E
A
L
E
K
L
N
EL
P
D
G
S
L
N
I
P
------------
K
------------
L
V
P
--------
G
LA--
G
N
--------
T
E
---
G
I
D
F
L
S
K
M
W
T
L
D
P
S
K
R
P
T
A
A
D
M
L
A
H
P
Y
L
A
H
L
H
D
E
E
D
E
P
T
C
--
P
C
-
P
---
F
--
L
W
A
H
-
E
--
S
T
P
M
G
V
S
E
L
R
R
A
F
W
A
D
I
V
D
Y
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
61.81
51%
-39
- C1 -
-
4QPA
1
MK01_HUMAN
A:
[24-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
---------
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
61.33
51%
-33
- C1 -
-
5BVF
1
MK01_HUMAN
A:
[19-355]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
-----------------
R
W
Y
R
A
P
E
I
M
------
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
60.95
51%
-36
- C1 -
-
4QP3
1
MK01_HUMAN
B:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
---------
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
60.64
51%
-37
- C1 -
-
4QP6
1
MK01_HUMAN
B:
[27-363]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
-
N
D
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
---
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
---------
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
60.23
51%
-47
- C1 -
-
5AX3
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
--
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
T
T
C
D
L
K
I
C
D
F
G
L
A
R
-
V
A
--------
F
L
T
E
Y
V
-
T
R
W
Y
R
A
P
E
I
M
L
---
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
------
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
59.41
46%
-90
- C1 -
-
4EWQ
6
MK14_HUMAN
A:
[41-371]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
--
A
R
--------
H
T
D
D
E
M
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
59.36
43%
6
- C1 -
-
4QNY
2
?
B:
[5-351]
---------------------------------
T
K
S
L
A
E
L
Q
A
E
----
V
C
R
L
D
D
R
Y
L
L
E
R
I
I
G
A
G
S
Y
G
V
V
I
R
A
R
D
T
K
S
D
N
R
L
V
A
M
K
R
V
N
K
E
I
F
E
E
V
I
L
A
K
R
I
L
R
E
I
K
L
L
A
H
F
N
D
D
N
I
I
G
L
R
N
I
L
T
-
P
E
D
-
P
-
E
N
F
D
H
F
Y
I
V
M
D
I
M
E
T
D
L
K
Q
V
L
R
S
G
Q
E
L
T
E
A
H
I
Q
--
F
F
I
Y
Q
A
L
R
A
L
H
I
I
H
S
A
G
V
I
H
R
D
I
T
P
A
N
I
L
V
N
T
N
C
D
L
K
I
C
D
F
G
L
A
K
----
E
E
N
D
Q
--
Y
M
T
D
Y
V
T
M
R
W
Y
R
A
P
E
L
V
M
E
D
K
D
Y
S
A
Q
I
D
V
W
G
I
G
C
I
L
G
E
L
L
G
S
R
P
L
F
Q
G
K
D
R
V
N
------------------
Q
L
D
K
I
V
D
V
I
G
T
P
-
S
E
E
D
I
N
S
V
G
S
S
A
A
Q
K
Y
L
K
K
K
S
--
H
R
P
Q
A
D
W
R
------------
Q
------------
R
Y
P
--------
T
----
A
S
--------
P
E
---
A
L
D
L
L
R
H
M
L
V
F
N
P
K
R
R
I
T
V
L
Q
A
M
R
H
P
F
L
E
Q
L
H
D
D
A
D
D
-----
Y
A
-
L
---
F
--
R
F
D
--
E
-----
K
T
I
V
D
V
K
R
A
I
Y
E
E
S
V
K
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
58.89
40%
-27
- C1 -
-
5AWM
1
JNK_DROME
A:
[37-384]
---------------------------------------------
D
T
N
F
T
I
H
S
R
Y
I
N
L
R
P
I
G
----
G
I
V
C
A
A
Y
-
D
T
I
T
Q
Q
N
V
A
I
K
K
L
-
S
R
P
F
Q
N
V
T
H
A
K
R
A
Y
R
E
F
K
L
M
K
L
V
N
H
K
N
I
I
G
L
L
N
A
F
T
-
P
Q
R
-
N
L
E
E
F
Q
D
V
Y
L
V
M
E
L
M
D
A
N
L
C
Q
V
I
----
Q
M
D
L
D
H
D
R
MS
Y
L
L
Y
Q
M
L
C
G
I
K
H
L
H
S
A
G
I
I
H
R
D
L
K
P
S
N
I
V
V
K
A
D
C
T
L
K
I
L
D
F
G
L
A
R
T
A
G
T
T
-----
F
M
M
---
V
V
T
R
Y
Y
R
A
P
E
V
I
L
G
M
-
G
Y
T
E
N
V
D
I
W
S
V
G
C
I
M
G
E
M
I
R
G
G
V
L
F
P
G
T
D
H
I
D
------------------
Q
W
N
K
I
I
E
Q
L
G
T
P
-
S
P
S
F
M
Q
R
L
Q
P
T
-
V
R
N
Y
V
E
N
R
P
--
R
Y
T
G
Y
S
F
D
------------
R
------------
L
F
P
DGLFPNDQ
N
----
S
R
--------
R
K
ASD
A
R
N
L
L
S
K
M
L
V
I
D
P
E
Q
R
I
S
V
D
E
A
L
K
H
E
Y
I
N
V
W
Y
D
A
E
E
V
D
A
P
--
A
P
E
P
---
Y
--
D
H
S
V
-----
R
E
H
T
V
E
Q
W
K
E
L
I
Y
E
E
V
M
D
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
58.50
51%
-52
- C1 -
-
4FV0
11
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
-
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
------
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
58.46
51%
-47
- C1 -
-
4ZXT
1
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
-
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
57.99
51%
-46
- C1 -
-
3SA0
1
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
-
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
57.92
43%
2
- C1 -
-
4QNY
1
?
A:
[5-351]
---------------------------------
T
K
S
L
A
E
L
Q
A
E
----
V
C
R
L
D
D
R
Y
L
L
E
R
I
I
G
A
G
S
Y
G
V
V
I
R
A
R
D
T
K
S
D
N
R
L
V
A
M
K
R
V
N
K
E
I
F
E
E
V
I
L
A
K
R
I
L
R
E
I
K
L
L
A
H
F
N
D
D
N
I
I
G
L
R
N
I
L
T
-
P
E
D
-
P
-
E
N
F
D
H
F
Y
I
V
M
D
I
M
E
T
D
L
K
Q
V
L
R
S
G
Q
E
L
T
E
A
H
I
Q
--
F
F
I
Y
Q
A
L
R
A
L
H
I
I
H
S
A
G
V
I
H
R
D
I
T
P
A
N
I
L
V
N
T
N
C
D
L
K
I
C
D
F
G
L
A
K
----
E
E
---
G
E
Y
M
T
D
Y
V
T
M
R
W
Y
R
A
P
E
L
V
M
E
D
K
D
Y
S
A
Q
I
D
V
W
G
I
G
C
I
L
G
E
L
L
G
S
R
P
L
F
Q
G
K
D
R
V
N
------------------
Q
L
D
K
I
V
D
V
I
G
T
P
-
S
E
E
D
I
N
S
V
G
S
S
A
A
Q
K
Y
L
K
K
K
S
--
H
R
P
Q
A
D
W
R
------------
Q
------------
R
Y
P
--------
T
----
A
S
--------
P
E
---
A
L
D
L
L
R
H
M
L
V
F
N
P
K
R
R
I
T
V
L
Q
A
M
R
H
P
F
L
E
Q
L
H
D
D
--------
Y
A
-
L
---
F
--
R
F
D
---------
T
I
V
D
V
K
R
A
I
Y
E
E
S
V
K
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
57.33
51%
-38
- C1 -
-
4XRJ
1
MK01_RAT
A:
[8-344]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
162
Blastp_CBE
57.10
51%
-43
- C1 -
-
4XNE
1
MK01_RAT
A:
[8-344]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
56.88
51%
-41
- C1 -
-
4FV7
5
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
56.86
51%
-46
- C1 -
-
4XP2
3
MK01_RAT
A:
[9-345]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
----------
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
56.75
51%
-50
- C1 -
-
4XP0
3
MK01_RAT
A:
[9-345]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
-
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
----------
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
56.65
51%
-31
- C1 -
-
6DMG
3
MK01_HUMAN
A:
[8-344]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
56.61
51%
-29
- C1 -
-
4FV3
4
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
56.53
51%
-46
- C1 -
-
6FI6
2
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
-
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
-----------
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
56.49
51%
-47
- C1 -
-
4XP3
12
MK01_RAT
A:
[9-345]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
---------
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
56.26
51%
-49
- C1 -
-
4G6O
5
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
--
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
-------
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
56.23
51%
-26
- C1 -
-
6FR1
6
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
-------
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
56.16
51%
-25
- C1 -
-
3QYW
11
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
--------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
56.14
51%
-53
- C1 -
-
4XOY
1
MK01_RAT
A:
[9-345]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
-----
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
-
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
---
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
----------
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
56.11
51%
-32
- C1 -
-
4FV2
9
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
-----
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
56.10
51%
-24
- C1 -
-
5LCK
1
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
55.97
51%
-55
- C1 -
-
4FUY
2
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
------
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
-
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
---------
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
55.85
51%
-24
- C1 -
-
6G9N
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
---
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
55.83
51%
-24
- C1 -
-
6FQ7
4
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
-------
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
55.80
51%
-27
- C1 -
-
6FMA
5
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
--------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
55.70
51%
-46
- C1 -
-
6FXV
4
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
-
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
---------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
55.65
51%
-27
- C1 -
-
6FJ0
5
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
--------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
55.57
51%
-23
- C1 -
-
6G8X
2
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
-----------
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
55.51
51%
-22
- C1 -
-
6Q7S
2
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
-------
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
55.47
51%
-23
- C1 -
-
6G9D
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
-------
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
55.45
51%
-25
- C1 -
-
4GVA
2
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
55.38
51%
-19
- C1 -
-
6G91
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
--------
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
55.37
51%
-26
- C1 -
-
3QYZ
13
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
--------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
55.29
51%
-41
- C1 -
-
5WP1
2
MK01_HUMAN
A:
[15-351]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
-
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
55.23
51%
-26
- C1 -
-
6G9K
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
-----
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
55.22
51%
-25
- C1 -
-
4ZZO
1
MK01_HUMAN
A:
[8-344]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
--------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
55.20
51%
-21
- C1 -
-
4ZZM
1
MK01_HUMAN
A:
[8-344]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
55.16
51%
-24
- C1 -
-
6FLV
5
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
---
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
55.14
51%
-22
- C1 -
-
6FJZ
1
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
55.09
51%
-20
- C1 -
-
6G9H
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
------
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
55.08
51%
-40
- C1 -
-
6G9J
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
-
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
55.07
51%
-28
- C1 -
-
4FV1
6
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
------
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
55.06
51%
-25
- C1 -
-
5NGU
1
MK01_HUMAN
A:
[37-373]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
--------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
54.99
51%
-26
- C1 -
-
6G92
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
---------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
54.97
51%
-26
- C1 -
-
4FUX
2
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
-------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
54.88
51%
-21
- C1 -
-
6FLE
2
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
--------
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
54.84
51%
-21
- C1 -
-
6GJD
4
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
---------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
54.83
51%
-23
- C1 -
-
5NHF
1
MK01_HUMAN
A:
[37-373]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
-------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
54.81
51%
-24
- C1 -
-
6GDQ
2
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
-----------
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
54.75
51%
-22
- C1 -
-
6FJB
1
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
-----------
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
54.70
51%
-21
- C1 -
-
6QAW
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
------------
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
54.61
51%
-26
- C1 -
-
6QA4
4
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
--
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
-----------
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
54.61
51%
-29
- C1 -
-
4FV8
2
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
-------------
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
---
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
54.59
51%
-25
- C1 -
-
6FI3
4
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
----------
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
54.59
51%
-22
- C1 -
-
6FN5
3
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
--
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
-----------
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
54.52
51%
-25
- C1 -
-
5LCJ
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
----
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
54.46
51%
-22
- C1 -
-
6G97
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
-----
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
54.44
51%
-21
- C1 -
-
6QAQ
2
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
------
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
54.42
51%
-23
- C1 -
-
6QA1
7
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
---------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
54.39
51%
-22
- C1 -
-
6GJB
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
-----
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
54.37
51%
-22
- C1 -
-
6G93
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
------
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
54.35
51%
-20
- C1 -
-
6G9M
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
-------
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
54.33
51%
-25
- C1 -
-
6GE0
4
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-----
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
54.32
51%
-20
- C1 -
-
6G9A
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
-----------
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
54.25
51%
-21
- C1 -
-
4ZZN
1
MK01_HUMAN
A:
[8-344]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
---------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
54.09
51%
-17
- C1 -
-
6QA3
2
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
-----------
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
54.08
51%
-25
- C1 -
-
4G6N
1
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
---------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
54.07
51%
-20
- C1 -
-
6Q7K
1
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
------
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
54.05
51%
-23
- C1 -
-
6FRP
5
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
---------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
54.01
51%
-26
- C1 -
-
4XOZ
1
MK01_RAT
A:
[9-345]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
--------
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
53.88
51%
-22
- C1 -
-
6QAH
2
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
-
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
---------
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
53.82
51%
-26
- C1 -
-
6QAL
2
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
---
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
-----------
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
53.79
51%
-18
- C1 -
-
4GT3
5
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
53.62
51%
-22
- C1 -
-
6Q7T
2
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
---------
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
53.59
51%
-33
- C1 -
-
4FV5
2
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
--------------
T
R
W
Y
R
A
P
E
I
M
L
N
S
----
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
53.54
51%
-28
- C1 -
-
6RQ4
1
?
A:
[27-362]
------------------------------------------------
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
----------
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
53.36
51%
-29
- C1 -
-
4FV9
2
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
--------------
T
R
W
Y
R
A
P
E
I
M
L
N
----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
53.08
46%
-55
- C1 -
-
3D7Z
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
--
K
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
52.37
51%
-23
- C1 -
-
6QAG
2
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
----------
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
51.99
51%
-32
- C1 -
-
4FV4
2
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
--
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
Y
C
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
------------
A
T
R
W
Y
R
A
P
E
I
M
L
-----
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
39.72
51%
-27
- C1 -
-
4GSB
7
MK01_RAT
A:
[22-358]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
---
G
M
V
C
S
A
Y
-
D
N
L
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
-
Y
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
C
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
C
I
I
N
L
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
38.22
46%
-39
- C1 -
-
3IPH
7
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
--
K
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
-
E
L
K
I
L
D
F
G
L
A
R
--
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
38.17
46%
-40
- C1 -
-
3D83
2
MK14_HUMAN
A:
[18-348]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
--
K
Q
K
L
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
-
E
L
K
I
L
D
F
G
L
A
R
H
T
D
D
E
-------
M
T
G
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
38.09
47%
-
- C1 -
-
1IAN
3
MK14_HUMAN
A:
[24-354]
------------------------------------------------
W
E
V
P
E
R
Y
Q
N
L
S
P
V
G
S
G
A
Y
G
S
V
C
A
A
F
-
D
T
K
T
G
L
R
V
A
V
K
K
L
-
S
R
P
F
Q
S
I
I
H
A
K
R
T
Y
R
E
L
R
L
L
K
H
M
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
R
-
S
L
E
E
F
N
D
V
Y
L
V
T
H
L
M
G
A
D
L
N
N
I
V
------
T
D
D
H
V
Q
--
F
L
I
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
D
I
I
H
R
D
L
K
P
S
N
L
A
V
N
E
D
C
E
L
K
I
L
D
F
----------------------
T
R
W
Y
R
A
P
E
I
M
L
N
W
M
H
Y
N
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
T
G
R
T
L
F
P
G
T
D
H
I
D
------------------
Q
L
K
L
I
L
R
L
V
G
T
P
-
G
A
E
L
L
K
K
I
S
S
E
S
A
R
N
Y
I
Q
S
L
T
--
Q
M
P
K
M
N
F
A
------------
N
------------
V
F
I
--------
G
----
A
N
--------
P
L
---
A
V
D
L
L
E
K
M
L
V
L
D
S
D
K
R
I
T
A
A
Q
A
L
A
H
A
Y
F
A
Q
Y
H
D
P
D
D
E
P
-
V
--
A
D
-
P
---
Y
--
D
Q
S
F
-
E
--
S
R
D
L
L
I
D
E
W
K
S
L
T
Y
D
E
V
I
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
37.96
51%
-16
- C1 -
-
4N0S
3
MK01_HUMAN
A:
[18-354]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
-
Y
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
-
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
D
D
L
P
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
36.74
51%
-18
- C1 -
-
6GDM
2
MK01_HUMAN
A:
[26-362]
-----------------------------------------------
V
F
D
V
G
P
R
Y
T
N
L
S
Y
I
G
E
G
A
Y
G
M
V
C
S
A
Y
-
D
N
V
N
K
V
R
V
A
I
K
K
I
--
S
P
F
E
H
Q
T
-
Y
Q
R
T
L
R
E
I
K
I
L
L
R
F
R
H
E
N
I
I
G
I
N
D
I
I
R
A
P
T
I
-
E
--
Q
M
K
D
V
Y
I
V
Q
D
L
M
E
T
D
L
Y
K
L
L
-
K
T
Q
H
L
S
N
D
H
I
C
--
Y
F
L
Y
Q
I
L
R
G
L
K
Y
I
H
S
A
N
V
L
H
R
D
L
K
P
S
N
L
L
L
N
-
T
T
D
L
K
I
-
D
F
G
L
A
R
-
V
A
D
P
D
H
D
H
T
G
F
L
T
E
Y
V
A
T
R
W
Y
R
A
P
E
I
M
L
N
S
K
G
Y
T
K
S
I
D
I
W
S
V
G
C
I
L
A
E
M
L
S
N
R
P
I
F
P
G
K
H
Y
L
D
------------------
Q
L
N
H
I
L
G
I
L
G
S
P
-
S
Q
E
D
L
N
I
I
N
L
-
K
A
R
N
Y
L
L
S
L
P
--
H
K
N
K
V
P
W
N
------------
R
------------
L
F
P
--------
N
----
A
D
--------
S
K
---
A
L
D
L
L
D
K
M
L
T
F
N
P
H
K
R
I
E
V
E
Q
A
L
A
H
P
Y
L
E
Q
Y
Y
D
P
S
D
E
P
I
A
--
E
A
-
P
---
F
--
K
F
D
M
-
E
--
L
----
K
E
K
L
K
E
L
I
F
E
E
T
A
R
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
33.56
49%
6
- C1 -
-
3GP0
2
MK11_HUMAN
A:
[2-346]
------------------------------------------------------------
V
G
S
G
A
Y
G
S
V
C
S
A
Y
-
D
A
R
L
R
Q
K
V
A
V
K
K
L
-
S
R
P
F
Q
S
L
I
H
A
R
R
T
Y
R
E
L
R
L
L
K
H
L
K
H
E
N
V
I
G
L
L
D
V
F
T
-
P
A
T
-
S
I
E
D
F
S
E
V
Y
L
V
T
T
L
M
G
A
D
L
N
N
I
V
-
K
C
Q
A
L
S
D
E
H
V
Q
--
F
L
V
Y
Q
L
L
R
G
L
K
Y
I
H
S
A
G
I
I
H
R
D
L
K
P
S
N
V
A
V
N
E
D
C
E
L
R
I
L
D
F
G
L
A
R
-----
Q
A
D
E
E
--
M
T
G
Y
V
A
T
R
W
Y
R
A
P
------
M
H
Y
-
Q
T
V
D
I
W
S
V
G
C
I
M
A
E
L
L
Q
G
K
A
L
F
P
G
S
D
Y
I
D
------------------
Q
L
K
R
I
M
E
V
V
G
T
P
-
S
P
E
V
L
A
K
I
S
S
E
H
A
R
T
Y
I
Q
S
L
P
--
P
M
P
Q
K
D
L
S
------------
S
------------
I
F
R
--------
G
----
A
N
--------
P
L
---
A
I
D
L
L
G
R
M
L
V
L
D
S
D
Q
R
V
S
A
A
E
A
L
A
H
A
Y
F
S
Q
Y
H
D
P
E
D
E
P
E
---
A
E
-
P
---
Y
--
D
E
S
V
-
E
--
A
K
E
R
T
L
E
E
W
K
E
L
T
Y
Q
E
V
L
S
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------