@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MP2K1_HUMAN: (2020-09-16 )
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSYGMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
Atome Classification :
(164 SA)
.........10........20........30........40........50........60.....--.--------..70........80..---......90........100...-....110.-....-.---.120.......130.......140..--.....150----....-.--.-.160---.........170.......180.......190.......200.......210---...-...--.220...--......230-----.----.----.-----.-----..-.240.......250.......260.......270.......--280.......290.......300.......310.......320...-..-.---.-330.......340.......350.......360.......370.......380.......390.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MPKKKPT
P
I
Q
L
NPAPDGSAVNGTSSAET
N
L
E
A
L
Q
K
K
L
E
ELEL
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
KVGELKD
D
--
D
--------
F
E
K
I
S
E
LGAGNG
G
V
V
F
---
K
VSHKPS
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
ECNS
P
Y
I
V
G
F
YGAFYSDG
E
I
S
I
C
M
E
--HMDGG
S
L
D
----
Q
V
L
K
-
K
--A-GR-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
HRDVKPS
N
I
L
VNSRG
E
I
K
L
C
DFGVS---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--VGTRSYM
S
P
-----
E
----R----L-----Q-----GT-HY
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
VGRYPIPPP
D
A
K
E
L
E
L
M
F
G
C
Q
V--EGDAAETPPRPRTPGRP
L
S
SYGMDSRP
P
M
A
I
F
E
L
L
D
Y
I
VNEPPPKL-PS-G---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
LIKNP
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
KRSDAEEV
D
F
A
G
W
L
C
S
TIGLNQPSTPTHAAGV
14
PsiBlast_PDB
96.80
99%
-108
- C2 -
-
3EQI
1
MP2K1_HUMAN
A:
[6-349]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
10
PsiBlast_PDB
96.11
99%
-109
- C2 -
-
3EQD
1
MP2K1_HUMAN
A:
[6-349]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
3
PsiBlast_PDB
95.51
99%
-106
- C2 -
-
6PP9
5
?
B:
[42-387]
-------------------------------------
E
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
A
--
M
A
--
N
A
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
----------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
----------
533
HHSearch
95.50
99%
-113
- C2 -
-
3EQI
1
MP2K1_HUMAN
A:
[12-349]
--------------------------------------------
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
12
PsiBlast_PDB
95.24
99%
-106
- C2 -
-
3EQG
2
MP2K1_HUMAN
A:
[6-348]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
17
PsiBlast_PDB
95.01
99%
-108
- C2 -
-
3ZLS
1
MP2K1_HUMAN
A:
[4-347]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
9
PsiBlast_PDB
94.66
99%
-107
- C2 -
-
3EQC
2
MP2K1_HUMAN
A:
[6-349]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
18
PsiBlast_PDB
94.14
99%
-107
- C2 -
-
3ZLX
1
MP2K1_HUMAN
A:
[4-347]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
536
HHSearch
93.91
99%
-111
- C2 -
-
3EQC
2
MP2K1_HUMAN
A:
[10-349]
------------------------------------------
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
13
PsiBlast_PDB
93.88
99%
-106
- C2 -
-
3EQH
2
MP2K1_HUMAN
A:
[6-348]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
2
PsiBlast_PDB
93.88
100%
-106
- C2 -
-
6U2G
2
MP2K1_HUMAN
A:
[44-384]
------------------------------------------
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
----------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
----------
20
PsiBlast_PDB
93.80
99%
-103
- C2 -
-
5BX0
1
MP2K1_HUMAN
A:
[4-347]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
16
PsiBlast_PDB
93.69
99%
-110
- C2 -
-
3ZLY
1
MP2K1_HUMAN
A:
[5-347]
---------------------------------------
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
-
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
23
Blastp_CBE
93.67
99%
-107
- C2 -
-
3ZLW
1
MP2K1_HUMAN
A:
[4-347]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
A
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
11
PsiBlast_PDB
93.66
99%
-104
- C2 -
-
3EQF
1
MP2K1_HUMAN
A:
[6-348]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
19
PsiBlast_PDB
93.61
99%
-103
- C2 -
-
3ZM4
1
MP2K1_HUMAN
A:
[5-347]
---------------------------------------
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--------
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
24
Blastp_CBE
91.54
99%
-102
- C2 -
-
3W8Q
1
MP2K1_HUMAN
A:
[1-344]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
Q
----------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
15
PsiBlast_PDB
90.39
99%
-106
- C2 -
-
5HZE
1
MP2K1_HUMAN
A:
[8-347]
------------------------------------------
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
----
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
1
PsiBlast_PDB
90.35
99%
-107
- C2 -
-
5KKR
-
MP2K1_RABIT
C:
[43-383]
----------------------------------------
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
---
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
A
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
41
Blastp_CBE
90.20
100%
-119
- C2 -
-
3VVH
2
?
B:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
----------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
42
Blastp_CBE
90.17
100%
-129
- C2 -
-
3VVH
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
---------
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
45
Blastp_CBE
90.13
100%
-119
- C2 -
-
3E8N
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
---
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
27
Blastp_CBE
90.06
99%
-107
- C2 -
-
5YT3
1
?
B:
[2-344]
---------------------------------------
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
D
--
M
A
--
N
D
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
----------------------------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
33
Blastp_CBE
89.99
100%
-116
- C2 -
-
4U7Z
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
---
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
38
Blastp_CBE
89.95
100%
-124
- C2 -
-
4LMN
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
21
Blastp_CBE
89.94
99%
-106
- C2 -
-
6Q0J
2
?
D:
[65-401]
------------------------------------------
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
A
--
M
A
--
N
A
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
---------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
--------------
7
PsiBlast_PDB
89.84
99%
-109
- C2 -
-
2Y4I
1
MP2K1_RABIT
C:
[39-383]
------------------------------------
L
L
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
---
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
A
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
39
Blastp_CBE
89.68
100%
-118
- C2 -
-
4ARK
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
5
PsiBlast_PDB
89.59
99%
-104
- C2 -
-
6Q0J
2
?
C:
[65-401]
------------------------------------------
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
A
--
M
A
--
N
A
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
---------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
--------------
4
PsiBlast_PDB
89.19
99%
-110
- C2 -
-
6NYB
2
?
B:
[78-405]
-------------------------------------------------------
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
A
--
M
A
--
N
A
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
-----------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
----------
535
HHSearch
89.17
100%
-117
- C2 -
-
4ARK
2
MP2K1_HUMAN
A:
[4-322]
---------------------------------------------------------------
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
538
HHSearch
89.12
99%
-108
- C2 -
-
3W8Q
1
MP2K1_HUMAN
A:
[10-344]
-----------------------------------------------
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
Q
----------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
28
Blastp_CBE
89.04
99%
-122
- C2 -
-
5YT3
1
MP2K1_HUMAN
A:
[1-344]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
------------------------
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
---------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
--------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
6
PsiBlast_PDB
88.95
99%
-104
- C2 -
-
6Q0T
2
?
C:
[65-401]
------------------------------------------
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
A
--
M
A
--
N
A
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
---------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
--------------
40
Blastp_CBE
88.73
100%
-118
- C2 -
-
3VVH
2
?
C:
[2-321]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
----------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
48
Blastp_CBE
88.71
100%
-124
- C2 -
-
3DV3
3
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
-----
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
25
Blastp_CBE
88.66
99%
-111
- C2 -
-
5YT3
1
?
D:
[1-344]
--------------------------------------
E
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
--
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
D
--
M
A
--
N
D
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
-----------------------------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
49
Blastp_CBE
88.64
99%
-121
- C2 -
-
3PP1
1
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
31
Blastp_CBE
88.36
100%
-122
- C2 -
-
4U81
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
534
HHSearch
88.27
100%
-117
- C2 -
-
3VVH
2
?
C:
[4-321]
---------------------------------------------------------------
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
----------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
50
Blastp_CBE
88.19
99%
-123
- C2 -
-
3MBL
2
MP2K1_HUMAN
A:
[2-321]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
43
Blastp_CBE
88.15
100%
-120
- C2 -
-
3V04
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
8
PsiBlast_PDB
88.07
99%
-117
- C2 -
-
5EYM
1
MP2K1_HUMAN
A:
[7-347]
----------------------------------------
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
---
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
---
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
----------
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----------------
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
47
Blastp_CBE
87.81
100%
-120
- C2 -
-
1S9J
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
44
Blastp_CBE
87.77
100%
-119
- C2 -
-
3V01
2
?
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
30
Blastp_CBE
87.45
100%
-122
- C2 -
-
2P55
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
29
Blastp_CBE
87.31
100%
-123
- C2 -
-
3EQB
2
MP2K1_HUMAN
A:
[2-322]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
32
Blastp_CBE
87.09
100%
-118
- C2 -
-
4U80
2
MP2K1_HUMAN
A:
[2-319]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
-------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
--------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
--------------
22
Blastp_CBE
86.55
99%
-115
- C2 -
-
5EYM
1
?
B:
[7-347]
----------------------------------------
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
---
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
---
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
----------
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----------------
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
---------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
537
HHSearch
85.96
98%
-119
- C2 -
-
3WIG
3
MP2K1_HUMAN
A:
[4-288]
---------------------------------------------------------------
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
---
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
-------
P
P
M
----------------------------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-------------
51
Blastp_CBE
85.32
90%
-120
- C2 -
-
3WIG
3
MP2K1_HUMAN
A:
[2-288]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
---
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
-----------------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-------------
539
HHSearch
85.28
96%
-112
- C2 -
-
3SLS
2
MP2K1_HUMAN
B:
[8-304]
------------------------------------------------
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
------------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
--
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
----
G
S
M
A
I
F
E
L
----------------------------------------
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
----------
55
Blastp_CBE
85.25
87%
-112
- C2 -
-
3SLS
2
MP2K1_HUMAN
A:
[4-304]
--------------------------------------------
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
----------
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
G
----------------------------------------------
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
----------
540
HHSearch
84.98
96%
-119
- C2 -
-
4AN3
2
MP2K1_HUMAN
A:
[5-282]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
E
--
M
A
--
N
E
----
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
R
P
P
M
A
I
F
E
L
L
D
Y
I
--------------------------------------------
V
N
E
P
P
P
K
L
-
P
S
-
A
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
54
Blastp_CBE
84.77
87%
-111
- C2 -
-
3SLS
2
MP2K1_HUMAN
B:
[4-304]
--------------------------------------------
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
------------
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
--
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
----
G
----------------------------------------
S
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
----------
53
Blastp_CBE
84.72
90%
-116
- C2 -
-
3ORN
3
MP2K1_HUMAN
A:
[2-288]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
------------------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
-------------
26
Blastp_CBE
84.48
99%
-117
- C2 -
-
5YT3
1
?
C:
[2-344]
---------------------------------------
L
E
L
D
E
Q
Q
R
K
R
L
E
A
F
L
T
Q
K
Q
K
V
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
------
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
---------------------------
S
Y
M
S
P
-----
E
----
R
----
L
---------------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
L
M
F
G
C
-------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
-----------
56
Blastp_CBE
84.46
85%
-114
- C2 -
-
1S9I
2
MP2K2_HUMAN
B:
[5-335]
------------------------------------------------------
T
Q
K
A
K
V
G
E
L
K
D
D
--
D
--------
F
E
R
I
S
E
L
G
A
G
N
G
G
V
V
T
---
K
V
Q
H
R
P
S
G
L
I
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
E
--
A
-
K
R
-----
I
P
E
E
I
L
G
K
V
S
I
A
V
L
R
G
L
A
Y
L
R
E
K
H
Q
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
----------
T
R
S
Y
M
A
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
L
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
A
I
F
G
R
--------------------------------
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
N
-
G
---
V
-
F
T
P
D
F
Q
E
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
M
L
T
N
H
T
F
I
K
R
S
E
V
E
E
V
D
F
A
G
W
L
C
K
T
L
R
L
------------
58
Blastp_CBE
83.66
86%
-116
- C2 -
-
4ANB
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
E
--
M
A
--
N
E
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
--------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
A
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
60
Blastp_CBE
83.56
86%
-119
- C2 -
-
4AN3
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
E
--
M
A
--
N
E
----
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
--------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
A
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
61
Blastp_CBE
82.79
86%
-119
- C2 -
-
4AN2
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
E
--
M
A
--
N
E
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
--------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
A
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
59
Blastp_CBE
82.23
86%
-116
- C2 -
-
4AN9
2
MP2K1_HUMAN
A:
[3-282]
-----------------------------------------------------------
L
G
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
E
--
M
A
--
N
E
---
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
--------------------------------------------
R
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
A
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
------------
46
Blastp_CBE
81.95
100%
-125
- C2 -
-
3DY7
2
MP2K1_HUMAN
A:
[2-304]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
-----
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
P
P
------------------------------------------
P
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
S
-
G
---
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
-----------------------------
57
Blastp_CBE
81.83
85%
-61
- C2 -
-
1S9I
2
MP2K2_HUMAN
A:
[6-339]
-------------------------------------------------------
Q
K
A
K
V
G
E
L
K
D
D
--
D
--------
F
E
R
I
S
E
L
G
A
G
N
G
G
V
V
T
---
K
V
Q
H
R
P
S
G
L
I
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
E
--
A
-
K
R
-----
I
P
E
E
I
L
G
K
V
S
I
A
V
L
R
G
L
A
Y
L
R
E
K
H
Q
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
--------
V
G
T
R
S
Y
M
A
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
L
A
V
G
R
Y
P
I
P
P
P
D
A
K
E
L
E
A
I
F
G
R
P
V
VD-------------------------
R
P
A
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
N
-
G
---
V
-
F
T
P
D
F
Q
E
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
M
L
T
N
H
T
F
I
K
R
S
E
V
E
E
V
D
F
A
G
W
L
C
K
T
L
R
L
N
Q
P
G
--------
52
Blastp_CBE
81.71
90%
-132
- C2 -
-
3OS3
2
MP2K1_HUMAN
A:
[2-286]
-------------------------------------------------------------
E
L
K
D
D
--
D
--------
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
---
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
L
E
I
K
P
-
A
I
R
N
Q
I
I
R
-
E
L
Q
V
-
L
---
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
--
H
M
D
G
G
S
L
D
----
Q
V
L
K
-
K
--
A
-
G
R
-----
I
P
E
Q
I
L
G
K
V
S
I
A
V
I
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
S
R
G
E
I
K
L
C
D
F
G
V
S
---
G
Q
L
-
I
D
S
--
M
A
--
N
S
F
--
V
G
T
R
S
Y
M
S
P
-----
E
----
R
----
L
-----
Q
-----
G
T
-
H
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
Y
P
I
---------------------------------------------
P
M
A
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
L
-
P
------
V
-
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
---------------
64
Blastp_CBE
54.45
37%
-21
- C2 -
-
6QHR
1
MP2K7_HUMAN
A:
[28-304]
-----------------------------------------------------------------
N
--
D
--------
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
---
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
R
S
G
N
K
-
E
E
N
K
R
I
L
M
-
D
L
D
V
-
V
LKS
H
D
C
--
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
--
L
M
--
G
T
C
A
----
E
K
L
K
-
K
RM
Q
-
G
P
-----
I
P
E
R
I
L
G
K
M
T
V
A
I
V
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
G
Q
I
K
L
C
D
F
G
I
S
---
G
R
L
---------------
A
G
C
A
A
Y
M
A
P
-----
E
----
R
----
I
-----
D
PP-------
Y
D
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
F
P
Y
K
-----------
N
C
K
T
--
D
------------------------------
F
E
V
L
T
K
V
L
Q
E
E
P
P
L
L
-
P
G
-
H
---
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
------------------
69
Blastp_CBE
54.41
37%
-12
- C2 -
-
6IB0
2
MP2K7_HUMAN
A:
[28-304]
-----------------------------------------------------------------
N
--
D
--------
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
---
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
R
S
G
N
K
-
E
E
N
K
R
I
L
M
-
D
L
D
V
-
V
LKS
H
D
C
--
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
--
L
M
--
G
T
C
A
----
E
K
L
K
-
K
RM
Q
-
G
P
-----
I
P
E
R
I
L
G
K
M
T
V
A
I
V
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
G
Q
I
K
L
C
D
F
G
I
S
---
G
R
----------------
A
G
C
A
A
Y
M
A
P
-----
E
----
R
----
I
-----
D
PPDPT
K
P
-
D
Y
D
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
F
P
Y
K
-----------
N
C
K
T
--
D
------------------------------
F
E
V
L
T
K
V
L
Q
E
E
P
P
L
L
-
P
G
-
H
---
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
------------------
77
Blastp_CBE
54.40
36%
-8
- C2 -
-
5Z1E
1
MP2K7_HUMAN
A:
[2-294]
--------------------------------------------------
T
G
Y
L
T
I
G
G
Q
R
Y
Q
A
E
I
N
--
D
--------
L
E
N
L
G
E
M
-----
G
Q
V
W
---
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
R
S
G
N
K
-
E
E
N
K
R
I
L
M
-
D
L
D
V
-
V
LKS
H
D
C
--
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
--
L
M
-
G
T
S
A
E
----
K
L
K
K
-
R
--
M
Q
G
P
-----
I
P
E
R
I
L
G
K
M
T
V
A
I
V
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
G
Q
I
K
L
C
D
F
G
I
S
---
G
------------------
G
C
A
A
Y
M
A
P
-----
E
----
R
----
I
-----
D
PPDPT-----
D
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
F
P
Y
K
-----------
N
C
K
T
--
D
------------------------------
F
E
V
L
T
K
V
L
Q
E
E
P
P
L
L
-
P
G
-
H
---
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
------------------
79
Blastp_CBE
53.93
36%
-21
- C2 -
-
5Z1D
2
MP2K7_HUMAN
A:
[2-293]
--------------------------------------------------
T
G
Y
L
T
I
G
G
Q
R
Y
Q
A
E
I
N
--
D
--------
L
E
N
L
G
E
M
-----
G
Q
V
W
---
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
R
S
G
N
K
-
E
E
N
K
R
I
L
M
-
D
L
D
V
-
V
LKS
H
D
C
--
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
--
L
M
--
G
T
C
A
----
E
K
L
K
-
K
RM
Q
-
G
P
-----
I
P
E
R
I
L
G
K
M
T
V
A
I
V
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
G
Q
I
K
L
S
D
F
G
I
S
----------------------
G
C
A
A
Y
M
A
P
-----
E
----
R
----
I
-----
D
PP----------
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
F
P
Y
K
-----------
N
C
K
T
--
D
------------------------------
F
E
V
L
T
K
V
L
Q
E
E
P
P
L
L
-
P
G
-
H
---
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
------------------
551
HHSearch
53.92
32%
-81
- C2 -
-
5J5T
1
M4K3_HUMAN
A:
[3-270]
----------------------------------------------------------------
Q
E
--
D
--------
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
---
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
--
E
D
F
A
V
V
Q
Q
-
E
I
I
M
-
M
---
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
--
F
C
G
G
G
S
L
Q
----
D
I
Y
H
-
V
--
T
-
G
P
-----
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
-
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
G
H
V
K
L
A
D
F
G
V
S
---
A
Q
I
-
T
A
T
IA-----
A
F
--
I
G
T
P
Y
W
M
A
P
-----
E
----
V
----
A
-----
A
VER--
K
G
-
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
M
T
K
S
---------------------------------
N
---------
F
Q
P
P
K
L
K
D
K
-
M
---
K
-
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
T
---------------------------
71
Blastp_CBE
53.43
36%
-12
- C2 -
-
3ALO
1
MP2K4_HUMAN
A:
[22-311]
-----------------------------------------------------------------
E
--
D
--------
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
---
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
-
K
E
Q
K
Q
L
L
M
-
D
L
D
V
V
M
---
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
--
L
M
-
S
T
S
F
D
----
K
F
Y
K
-
Y
--
V
-
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
---
G
Q
L
-
V
D
S
--
I
A
--
K
T
R
D-
A
G
C
R
P
Y
M
A
P
-----
E
----
R
----
I
-----
D
-----
P
---
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
N
-------------------------------------------
S
V
F
D
Q
L
T
Q
V
V
K
G
D
P
P
Q
L
-
S
N
-
S
EER
E
-
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
---------
92
Blastp_CBE
52.83
34%
-39
- C2 -
-
4O27
1
STK24_HUMAN
B:
[8-261]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
--
Q
I
KR
N
E
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
155
Blastp_CBE
52.02
31%
-56
- C2 -
-
2J51
5
SLK_HUMAN
A:
[36-297]
----------------------------------------------------------------
E
D
--
F
--------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
---
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
-
E
L
E
D
Y
M
V
--
E
I
D
I
-
L
---
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
--
F
C
A
G
G
A
V
D
----
A
V
M
L
-
E
--
L
-
E
R
P----
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
---
A
K
N
-
T
R
T
--
I
Q
RR
D
S
F
--
I
G
T
P
Y
W
M
A
P
-----
E
----
V
----
V
MCETS
K
-----
D
R
-
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-
H
H
E
L
N
------------------------------------
P
M
R
V
--
L
L
K
I
A
K
S
E
P
P
T
L
A
-
Q
P
-
S
---
R
-
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--------------------------------
63
Blastp_CBE
51.70
38%
-19
- C2 -
-
3FME
1
MP2K6_HUMAN
A:
[3-289]
-------------------------------------------------------------
E
V
K
A
D
--
D
--------
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
---
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
---
N
S
-
Q
E
Q
K
R
L
L
M
-
D
L
D
I
S
M
---
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
--
L
M
D
T
-
S
L
D
KFYK
Q
V
I
D
-
K
--
G
-
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
------------------------
A
G
C
K
P
Y
M
A
P
-----
E
----
R
INPE
L
-----
N
-----
Q
---
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
--------------------
D
S
W
G
T
P
-----------------------
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
L
-
P
A
-
D
---
K
-
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
-------------
66
Blastp_CBE
51.36
37%
-8
- C2 -
-
6QG7
1
MP2K7_HUMAN
A:
[28-304]
-----------------------------------------------------------------
N
--
D
--------
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
---
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
R
S
G
N
K
-
E
E
N
K
R
I
L
M
-
D
L
D
V
-
V
LKS
H
D
C
--
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
--
L
M
--
G
T
C
A
----
E
K
L
K
-
K
RM
Q
-
G
P
-----
I
P
E
R
I
L
G
K
M
T
V
A
I
V
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
G
Q
I
K
L
C
D
F
G
I
S
---
G
R
L
---------------
A
G
C
A
A
Y
M
A
P
-----
E
----
R
----
I
-----
D
P----------
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
F
P
Y
K
-----------
N
C
K
T
--
D
------------------------------
F
E
V
L
T
K
V
L
Q
E
E
P
P
L
L
-
P
G
-
H
---
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
------------------
154
Blastp_CBE
51.34
31%
-54
- C2 -
-
2UV2
6
SLK_HUMAN
A:
[36-297]
----------------------------------------------------------------
E
D
--
F
--------
W
E
I
I
G
E
L
G
D
--
F
G
K
V
Y
---
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
-
E
L
E
D
Y
M
V
--
E
I
D
I
-
L
---
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
--
F
C
A
G
G
A
V
D
----
A
V
M
L
-
E
--
L
-
E
R
P----
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
---
A
K
N
-
T
R
T
--
I
Q
RR
D
S
F
--
I
G
T
P
Y
W
M
A
P
-----
E
----
V
----
V
MCETS
K
-----
D
R
-
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-
H
H
E
L
N
------------------------------------
P
M
R
V
--
L
L
K
I
A
K
S
E
P
P
T
L
A
-
Q
P
-
S
---
R
-
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--------------------------------
125
Blastp_CBE
50.90
32%
-43
- C2 -
-
4FZA
3
STK26_HUMAN
B:
[10-263]
-----------------------------------------------------------------------------
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
R
--
A
-
G
P
-----
F
D
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
Q
G
D
V
K
L
A
A
F
G
V
A
---
G
Q
L
-
T
D
T
--
Q
I
KR
N
T
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
Q
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
----
P
P
N
S
------------------------------------
D
M
H
P
M
R
V
L
F
----
L
I
P
K
N
N
P
P
T
L
--
V
-
G
---
D
-
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
-----------------------------
151
Blastp_CBE
50.44
31%
-40
- C2 -
-
4USF
1
SLK_HUMAN
B:
[15-276]
----------------------------------------------------------------
E
D
--
F
--------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
---
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
-
E
L
E
D
Y
M
V
--
E
I
D
I
-
L
---
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
--
F
C
A
G
G
A
V
D
----
A
V
M
L
-
E
--
L
-
E
R
P----
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
---
A
K
N
------------
F
--
I
G
T
P
Y
W
M
A
P
-----
E
----
V
----
V
MCETS
K
-----
D
R
-
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-
H
H
E
L
N
------------------------------------
P
M
R
V
--
L
L
K
I
A
K
S
E
P
P
T
L
A
-
Q
P
-
S
---
R
-
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--------------------------------
67
Blastp_CBE
50.23
37%
-11
- C2 -
-
6QG4
1
MP2K7_HUMAN
A:
[28-304]
-----------------------------------------------------------------
N
--
D
--------
L
E
N
L
G
E
M
-----
G
Q
V
W
---
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
R
S
G
N
K
-
E
E
N
K
R
I
L
M
-
D
L
D
V
-
V
LKS
H
D
C
--
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
--
L
M
--
G
T
C
A
----
E
K
L
K
-
K
RM
Q
-
G
P
-----
I
P
E
R
I
L
G
K
M
T
V
A
I
V
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
G
Q
I
K
L
C
D
F
G
I
S
---
G
R
-------------------
A
A
Y
M
A
P
-----
E
----
R
----
I
-----
D
P----------
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
F
P
Y
K
-----------
N
C
K
T
--
D
------------------------------
F
E
V
L
T
K
V
L
Q
E
E
P
P
L
L
-
P
G
-
H
---
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
------------------
62
Blastp_CBE
50.12
38%
1
- C2 -
-
3VN9
1
MP2K6_HUMAN
A:
[47-333]
-------------------------------------------------------------
E
V
K
A
D
--
D
--------
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
---
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
A
T
V
N
S
-
Q
E
Q
K
R
L
L
M
-
D
L
D
I
S
M
---
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
--
L
M
D
T
-
S
L
D
KFYK
Q
V
I
D
-
K
--
G
-
Q
T
-----
I
P
E
D
I
L
G
K
I
A
V
S
I
V
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
A
L
G
Q
V
K
M
C
D
F
G
I
S
---
G
Y
L
-
V
D
S
--
V
A
--
K
T
I
D-
A
G
C
K
P
Y
M
A
P
-----
E
----
R
INPE
L
-----
N
-----
Q
K
-
G
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
F
P
Y
--------------------
D
S
W
G
T
P
-----------------------
F
Q
Q
L
K
Q
V
V
E
E
P
S
P
Q
L
-
P
A
-
D
---
K
-
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
G
-------------
68
Blastp_CBE
50.11
37%
-3
- C2 -
-
6QFT
1
MP2K7_HUMAN
A:
[28-304]
-----------------------------------------------------------------
N
--
D
--------
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
---
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
R
S
G
N
K
-
E
E
N
K
R
I
L
M
-
D
L
D
V
-
V
LKS
H
D
C
--
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
--
L
M
--
G
T
C
A
----
E
K
L
K
-
K
RM
Q
-
G
P
-----
I
P
E
R
I
L
G
K
M
T
V
A
I
V
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
G
Q
I
K
L
C
D
F
G
I
S
---
G
R
------------------
C
A
A
Y
M
A
P
-----
E
----
R
----
I
-----
D
P-----------
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
F
P
Y
K
-----------
N
C
K
T
--
D
------------------------------
F
E
V
L
T
K
V
L
Q
E
E
P
P
L
L
-
P
G
-
H
---
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
------------------
70
Blastp_CBE
49.91
37%
-30
- C2 -
-
6IB2
1
MP2K7_HUMAN
A:
[28-304]
-----------------------------------------------------------------
N
--
D
--------
L
E
N
L
G
E
M
-----
G
Q
V
W
---
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
R
S
G
N
K
-
E
E
N
K
R
I
L
M
-
D
L
D
V
-
V
LKS
H
D
C
--
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
--
L
M
--
G
T
C
A
----
E
K
L
K
-
K
RM
Q
-
G
P
-----
I
P
E
R
I
L
G
K
M
T
V
A
I
V
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
G
Q
I
K
L
C
D
F
----------------------------
A
Y
M
A
P
-----
E
----
R
----
I
-----
D
------------
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
F
P
Y
K
K
-----------
C
K
T
--
D
------------------------------
F
E
V
L
T
K
V
L
Q
E
E
P
P
L
L
-
P
G
-
H
---
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
------------------
65
Blastp_CBE
49.89
37%
-2
- C2 -
-
6QHO
1
MP2K7_HUMAN
A:
[28-304]
-----------------------------------------------------------------
N
--
D
--------
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
---
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
R
S
G
N
K
-
E
E
N
K
R
I
L
M
-
D
L
D
V
-
V
LKS
H
D
C
--
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
--
L
M
--
G
T
C
A
----
E
K
L
K
-
K
RM
Q
-
G
P
-----
I
P
E
R
I
L
G
K
M
T
V
A
I
V
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
E
R
G
Q
I
K
L
C
D
F
G
I
S
---
G
R
---------------------
Y
M
A
P
-----
E
----
R
----
I
-----
D
P-----------
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
F
P
Y
K
-----------
N
C
K
T
--
D
------------------------------
F
E
V
L
T
K
V
L
Q
E
E
P
P
L
L
-
P
G
-
H
---
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
------------------
129
Blastp_CBE
49.56
31%
-47
- C2 -
-
6HXF
1
STK10_HUMAN
A:
[21-279]
-----------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
---
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
--
E
E
-
E
L
E
D
Y
I
V
--
E
I
E
I
-
L
---
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
--
F
C
P
G
G
A
V
D
----
A
I
M
L
-
E
--
L
-
D
R
G----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
---
A
K
N
-
L
K
---
Q
K
--
R
D
F
--
I
G
T
P
Y
W
M
A
P
-----
E
VVMC
E
----
M
-----
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
--
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
-
T
P
-
S
---
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------
74
Blastp_CBE
49.49
36%
-8
- C2 -
-
3ALN
1
MP2K4_HUMAN
A:
[22-311]
-----------------------------------------------------------------
E
--
D
--------
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
---
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
-
K
E
Q
K
Q
L
L
M
-
D
L
D
V
V
M
---
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
--
L
M
-
S
T
S
F
D
----
K
F
Y
K
-
Y
--
V
-
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
---
G
Q
--------------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
K
W
--------------------------------------------------
T
Q
V
V
K
G
D
P
P
Q
L
-
S
N
-
S
EER
E
-
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
---------
150
Blastp_CBE
49.35
31%
-43
- C2 -
-
6HVD
4
SLK_HUMAN
A:
[15-276]
----------------------------------------------------------------
E
D
--
F
--------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
---
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
-
E
L
E
D
Y
M
V
--
E
I
D
I
-
L
---
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
--
F
C
A
G
G
A
V
D
----
A
V
M
L
-
E
--
L
-
E
R
P----
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
---
A
K
N
-
T
R
--------
S
F
--
I
G
T
P
Y
W
M
A
P
-----
E
----
V
----
V
MCETS
K
-----
D
R
-
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-
H
H
E
L
N
------------------------------------
P
M
R
V
--
L
L
K
I
A
K
S
E
P
P
T
L
A
-
Q
P
-
S
---
R
-
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--------------------------------
131
Blastp_CBE
48.80
32%
-57
- C2 -
-
6EIM
5
STK10_HUMAN
A:
[21-279]
-----------------------------------------------------------------------------
W
E
I
V
G
E
L
------
K
V
Y
---
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
-
E
L
E
D
Y
I
V
--
E
I
E
I
-
L
---
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
--
F
C
P
G
G
A
V
D
----
A
I
M
L
-
E
--
L
-
D
R
G----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
---
A
K
N
-
L
K
T
--
L
Q
KR
D
S
F
--
I
G
T
P
Y
W
M
A
P
EVVMC
E
----
T
----
M
-----
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
----
Q
I
E
P
P
H
-
H
E
L
N
------------------------------------
P
M
R
V
--
L
L
A
I
A
A
S
D
P
P
T
L
L
-
T
P
-
S
---
K
-
W
S
V
E
F
R
D
F
L
A
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------
73
Blastp_CBE
48.08
36%
-18
- C2 -
-
3ALN
1
MP2K4_HUMAN
B:
[22-312]
-----------------------------------------------------------------
E
--
D
--------
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
---
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
S
T
V
D
E
-
K
E
Q
K
Q
L
L
M
-
D
L
D
V
V
M
---
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
--
L
M
-
S
T
S
F
D
----
K
F
Y
K
-
Y
--
V
-
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
G
I
S
---
G
Q
L
-------------------------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
P
Y
P
----------------------------------------------------------
D
P
P
Q
L
-
S
N
-
S
EER
E
-
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
A
--------
127
Blastp_CBE
47.75
31%
-46
- C2 -
-
6HXF
2
STK10_HUMAN
C:
[21-279]
-----------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
---
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
-
E
E
-
E
L
E
D
Y
I
V
--
E
I
E
I
-
L
---
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
--
F
C
P
G
G
A
V
D
----
A
I
M
L
-
E
--
L
-
D
R
G----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
---
A
K
N
-
L
K
L
--
Q
K
--
R
D
F
--
I
G
T
P
Y
W
M
A
P
-----
E
VVMC
E
----
M
-----
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
--
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
-
T
P
-
S
---
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------
121
Blastp_CBE
47.57
34%
-39
- C2 -
-
4QML
2
STK24_HUMAN
A:
[31-284]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
546
HHSearch
47.20
37%
-49
- C2 -
-
6AO5
1
STK3_HUMAN
A:
[13-268]
------------------------------------------------------------------------------
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
---
K
A
I
H
-----
V
V
A
I
K
Q
---------
D
L
Q
E
I
I
K
-
E
I
S
I
-
M
---
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
----
L
W
I
V
M
E
--
Y
C
G
A
G
S
V
S
----
D
I
I
R
-
L
--
R
N
K
T
-----
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
-
R
K
I
H
R
N
I
K
A
G
N
I
L
L
N
T
E
G
H
A
K
L
A
D
F
G
V
A
------------------
V
--
I
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
Q
-----
E
I
-
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
P
T
-------------------------------------------
N
P
P
P
T
F
R
-
K
P
-
E
---
L
-
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
I
K
N
A
K
P
---------------------------
153
Blastp_CBE
47.17
31%
-54
- C2 -
-
2JFL
6
SLK_HUMAN
A:
[36-297]
----------------------------------------------------------------
E
D
--
F
--------
W
E
I
I
G
E
L
G
D
G
A
F
G
K
V
Y
---
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
S
E
E
-
E
L
E
D
Y
M
V
--
E
I
D
I
-
L
---
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
--
F
C
A
G
G
A
V
D
----
A
V
M
L
-
E
--
L
-
E
R
P----
L
T
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
-
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
---
A
K
N
-
T
R
I
--
Q
R
--
R
D
F
--
I
G
T
P
Y
W
M
A
P
-----
E
----
V
----
V
MCETS
K
-----
D
R
-
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
----
E
I
E
P
P
-
H
H
E
L
N
------------------------------------
P
M
R
V
--
L
L
K
I
A
K
S
E
P
P
T
L
A
-
Q
P
-
S
---
R
-
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
--------------------------------
96
Blastp_CBE
47.05
34%
-38
- C2 -
-
4U8Z
1
STK24_HUMAN
A:
[16-269]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
107
Blastp_CBE
46.83
34%
-32
- C2 -
-
4QNA
1
STK24_HUMAN
A:
[31-284]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
105
Blastp_CBE
46.59
34%
-36
- C2 -
-
4QO9
4
STK24_HUMAN
B:
[31-284]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
102
Blastp_CBE
46.54
34%
-37
- C2 -
-
3A7H
1
STK24_HUMAN
A:
[24-277]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
114
Blastp_CBE
46.52
34%
-37
- C2 -
-
4QMT
2
STK24_HUMAN
A:
[31-284]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
109
Blastp_CBE
46.51
34%
-36
- C2 -
-
4QMY
2
STK24_HUMAN
A:
[31-284]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
108
Blastp_CBE
46.49
34%
-37
- C2 -
-
4QMZ
1
STK24_HUMAN
A:
[31-284]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
115
Blastp_CBE
46.44
34%
-38
- C2 -
-
4QMS
2
STK24_HUMAN
A:
[31-284]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
95
Blastp_CBE
46.44
34%
-36
- C2 -
-
4W8D
1
STK24_HUMAN
A:
[16-269]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
100
Blastp_CBE
46.38
34%
-37
- C2 -
-
3A7I
1
STK24_HUMAN
A:
[24-277]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
111
Blastp_CBE
46.28
34%
-35
- C2 -
-
4QMW
2
STK24_HUMAN
A:
[31-284]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
118
Blastp_CBE
46.19
34%
-34
- C2 -
-
4QMO
3
STK24_HUMAN
A:
[31-284]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
94
Blastp_CBE
45.82
34%
-36
- C2 -
-
4W8E
1
STK24_HUMAN
A:
[16-269]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
117
Blastp_CBE
45.64
34%
-33
- C2 -
-
4QMP
2
STK24_HUMAN
A:
[31-284]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
142
Blastp_CBE
45.59
31%
-54
- C2 -
-
4EQU
2
STK10_HUMAN
B:
[21-279]
-----------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
---
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
----
E
E
-
E
L
E
D
Y
I
V
--
E
I
E
I
-
L
---
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
--
F
C
P
G
G
A
V
D
----
A
I
M
L
-
E
--
L
-
D
R
G----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
---
A
K
N
-
L
----------
F
--
I
G
T
P
Y
W
M
A
P
EVVMC
E
----
T
----
M
-----
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
--
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
-
T
P
-
S
---
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------
128
Blastp_CBE
45.57
31%
-33
- C2 -
-
6HXF
5
STK10_HUMAN
B:
[21-279]
-----------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
---
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
-
E
L
E
D
Y
I
V
--
E
I
E
I
-
L
---
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
--
F
C
P
G
G
A
V
D
----
A
I
M
L
-
E
--
L
-
D
R
G----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
---
A
K
N
-
L
K
L
--
Q
K
--
R
D
F
--
I
G
T
P
Y
W
M
A
P
-----
E
VVMC
E
----
M
-----
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
--
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
-
T
P
-
S
---
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------
99
Blastp_CBE
45.44
34%
-34
- C2 -
-
3A7J
1
STK24_HUMAN
A:
[24-277]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
106
Blastp_CBE
45.31
34%
-36
- C2 -
-
4QO9
4
STK24_HUMAN
A:
[31-284]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
135
Blastp_CBE
45.08
31%
-46
- C2 -
-
5OWR
1
STK10_HUMAN
A:
[21-279]
-----------------------------------------------------------------------------
W
E
I
V
G
E
L
G
----
G
K
V
Y
---
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
--
E
-
E
L
E
D
Y
I
V
--
E
I
E
I
-
L
---
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
--
F
C
P
G
G
A
V
D
----
A
I
M
L
-
E
--
L
-
D
R
G----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
---
A
K
N
-
L
K
T
--
L
Q
K---------
P
Y
W
M
A
P
EVVMC
E
----
T
----
M
-----
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
--
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
-
T
P
-
S
---
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------
101
Blastp_CBE
45.03
34%
-33
- C2 -
-
3A7H
1
STK24_HUMAN
B:
[24-277]
-----------------------------------------------------------------------------
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
---
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
A
E
-
D
E
I
E
D
I
Q
Q
-
E
I
T
V
-
L
---
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
--
Y
L
G
G
G
S
A
L
----
D
L
L
--
E
--
P
-
G
P
-----
L
D
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
T
Q-
I
K
--
R
N
F
--
V
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
K
-----
Q
S
-
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
----
P
P
H
S
-
E
L
H
------------------------------------
P
M
K
V
L
F
L
---
I
P
K
N
N
P
P
T
L
--
E
-
G
---
N
-
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
-----------------------------
126
Blastp_CBE
44.48
31%
-33
- C2 -
-
6HXF
4
STK10_HUMAN
D:
[21-279]
-----------------------------------------------------------------------------
W
E
I
V
G
E
L
G
D
G
A
F
G
K
V
Y
---
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
S
E
E
-
E
L
E
D
Y
I
V
--
E
I
E
I
-
L
---
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
--
F
C
P
G
G
A
V
D
----
A
I
M
L
-
E
--
L
-
D
R
G----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
---
A
K
N
-
L
K
L
--
Q
K
--
R
D
F
--
I
G
T
P
Y
W
M
A
P
-----
E
VVMC
E
----
M
-----
K
--------
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
--
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
-
T
P
-
S
---
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------
81
Blastp_CBE
43.81
36%
-36
- C2 -
-
6AO5
1
STK3_HUMAN
A:
[13-266]
------------------------------------------------------------------------------
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
---
K
A
I
H
-----
V
V
A
I
K
Q
---------
D
L
Q
E
I
I
K
-
E
I
S
I
-
M
---
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
----
L
W
I
V
M
E
--
Y
C
G
A
G
S
V
S
----
D
I
I
R
L
R
--
N
-
K
T
-----
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
-
H
R
N
I
K
A
G
N
I
L
L
N
T
E
G
H
A
K
L
A
D
F
G
V
A
------------------
V
--
I
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
Q
-----
E
I
-
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
----
P
P
Y
A
------------------------------------
D
I
H
P
M
R
A
I
F
----
M
I
P
T
N
P
P
P
T
F
-
R
K
P
E
---
L
-
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
I
K
N
A
-----------------------------
143
Blastp_CBE
43.58
31%
-59
- C2 -
-
4EQU
2
STK10_HUMAN
A:
[21-279]
-----------------------------------------------------------------------------
W
E
I
V
G
E
L
-----
G
K
V
Y
---
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
-------
E
L
E
D
Y
I
V
--
E
I
E
I
-
L
---
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
--
F
C
P
G
G
A
V
D
----
A
I
M
L
-
E
--
L
-
D
R
G----
L
T
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
---
A
K
N
-
L
-------------
I
G
T
P
Y
W
M
A
P
EVVMC
E
----
T
----
M
-----
K
-----
D
T
-
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
--------------------
Q
I
--
E
------
P
P
H
H
E
L
-------------
N
P
M
R
V
--
L
L
K
I
A
K
S
D
P
P
T
L
L
-
T
P
-
S
---
K
-
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
--------------------------------
157
Blastp_CBE
43.01
32%
-46
- C2 -
-
5J5T
1
M4K3_HUMAN
A:
[4-267]
-----------------------------------------------------------------
E
--
D
--------
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
---
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
--
P
-
G
E
D
F
A
V
V
Q
Q
E
I
I
M
-
M
---
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
--
F
C
G
G
G
S
L
Q
----
D
I
Y
H
-
V
--
T
-
G
P
-----
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
-
M
H
R
D
I
K
G
A
N
I
L
L
D
N
-
G
H
V
K
L
A
D
F
G
V
S
---
A
Q
I
-
T
A
T
--
I
A
K---
F
--
I
G
T
P
Y
W
M
A
P
EVAAV
E
----
R
----
K
-----
G
-----
G
---
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
----
E
L
Q
P
P
-------
M
F
-----------------------------
D
L
H
P
M
R
A
L
F
L
M
T
K
--
S
N
F
Q
P
P
K
L
-
K
D
-
K
---
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
------------------------------
398
Blastp_CBE
39.37
33%
-66
- C2 -
-
2V0D
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
------
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
39.21
34%
17
- C2 -
-
5DH3
1
STK3_HUMAN
B:
[20-283]
--------------------------------------------------------------------
S
LTKQPEEV
F
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
---
K
A
I
H
K
E
S
G
Q
V
V
A
I
K
Q
V
P
V
E
----
S
D
L
Q
E
I
I
K
-
E
I
S
I
-
M
---
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
--
Y
C
G
A
G
S
V
S
----
D
I
I
R
L
R
--
N
-
K
T
-----
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
-
H
R
D
I
K
A
G
N
I
L
L
N
T
E
G
H
A
K
L
A
D
F
G
V
A
---
G
Q
L
-
T
D
M
--
A
K
--
R
N
V
--
I
G
T
P
F
W
M
A
P
-----
E
----
V
----
I
-----
Q
-----
E
I
-
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
----
P
P
Y
A
------------------------------------
D
I
H
P
M
R
A
I
F
----
M
I
P
T
N
P
P
P
T
F
-
R
K
P
E
---
L
-
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
I
K
N
A
-----------------------------
480
Blastp_CBE
39.01
33%
-46
- C2 -
-
1FIN
1
CDK2_HUMAN
C:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
38.76
32%
-53
- C2 -
-
2IW6
1
CDK2_HUMAN
C:
[6-208]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
T
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
---
R
A
F
G
V
P
V
--
R
T
--
Y
H
E
--
V
V
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
38.56
33%
-63
- C2 -
-
6Q4A
1
CDK2_HUMAN
A:
[10-212]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
-
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
38.48
33%
-41
- C2 -
-
2C5O
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
38.38
33%
-46
- C2 -
-
2I40
1
CDK2_HUMAN
C:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
38.32
33%
-40
- C2 -
-
1FIN
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
38.23
33%
-59
- C2 -
-
6Q4K
2
CDK2_HUMAN
A:
[10-212]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
-
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
38.20
33%
-37
- C2 -
-
2C5O
1
CDK2_HUMAN
C:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
38.13
33%
-65
- C2 -
-
4FKL
1
CDK2_HUMAN
A:
[3-205]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
38.04
33%
-59
- C2 -
-
6Q4B
1
CDK2_HUMAN
A:
[10-212]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
37.93
32%
-44
- C2 -
-
2IW8
1
CDK2_HUMAN
A:
[6-208]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
--
H
V
D
Q
-
D
L
K
----
K
F
M
D
-
A
--
S
-
A
L
TG---
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
---
R
A
F
G
V
P
V
--
R
T
--
Y
H
E
--
V
V
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
37.81
33%
-44
- C2 -
-
2C5X
1
CDK2_HUMAN
C:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
37.78
33%
-40
- C2 -
-
2WEV
1
CDK2_HUMAN
C:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
37.76
33%
-62
- C2 -
-
6Q3C
1
CDK2_HUMAN
A:
[10-212]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
--------
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
K
-
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
37.72
33%
-58
- C2 -
-
6Q4D
6
CDK2_HUMAN
A:
[10-212]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
-K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
37.68
33%
-68
- C2 -
-
1CKP
2
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF------------------
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
37.61
33%
-43
- C2 -
-
1FVV
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
37.55
33%
-33
- C2 -
-
2C5X
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
37.34
33%
-64
- C2 -
-
3FZ1
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
-------
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
------------
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
37.26
33%
-41
- C2 -
-
3EJ1
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
37.02
33%
-38
- C2 -
-
2WEV
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
36.97
33%
-59
- C2 -
-
6Q4G
1
CDK2_HUMAN
A:
[10-212]
-----------------------------------------------------------------
E
--
N
--------
F
E
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
------
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
-----------------
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
370
Blastp_CBE
36.87
33%
-40
- C2 -
-
3EJ1
1
CDK2_HUMAN
C:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
36.83
33%
-57
- C2 -
-
5A14
1
CDK2_HUMAN
A:
[3-205]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
--
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
-----------------
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
36.82
32%
-55
- C2 -
-
6Q4I
2
CDK2_HUMAN
A:
[10-212]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-------
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
---
R
A
F
-
L
-----
R
--
T
Y
T
HE
V
V
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
36.74
33%
-64
- C2 -
-
6Q4J
2
CDK2_HUMAN
A:
[10-212]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
--------
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
---
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
36.67
33%
-65
- C2 -
-
3S2P
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
--------
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF------------------
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
36.54
33%
-37
- C2 -
-
1PXI
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
36.36
33%
-39
- C2 -
-
3TIZ
8
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
36.03
33%
-65
- C2 -
-
2VTH
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
---------
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF------------------
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
35.89
33%
-52
- C2 -
-
4ERW
14
CDK2_HUMAN
A:
[10-212]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
-----
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
K
-
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
35.81
33%
-36
- C2 -
-
5ANE
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
35.74
33%
-34
- C2 -
-
1PXJ
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
35.58
33%
-38
- C2 -
-
4EZ7
6
CDK2_HUMAN
A:
[10-212]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
D
T
E
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
35.24
33%
-37
- C2 -
-
3LFN
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RA--------------
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
35.10
33%
-70
- C2 -
-
4D1X
1
CDK2_HUMAN
A:
[3-204]
--------------------------------------------------------------------
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
-------------------
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
34.82
33%
-44
- C2 -
-
2I40
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
-----
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
34.22
33%
-33
- C2 -
-
3TIY
12
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
----
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
33.54
33%
-40
- C2 -
-
3S0O
1
CDK2_HUMAN
A:
[10-212]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
R
L
---
T
E
G
V
P
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
--
A
RAF
G
V
P
-
V
R
T
--
Y
T
--
H
E
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
32.84
33%
-41
- C2 -
-
2VTT
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
T
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
N
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
----------------------
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
32.12
33%
-52
- C2 -
-
5ANG
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
--
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
----------
S
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
-------------------
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
31.38
33%
-46
- C2 -
-
5FP5
2
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
G
-
Y
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
---
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
L
------------------------
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
29.69
36%
-43
- C2 -
-
3ALN
1
MP2K4_HUMAN
C:
[22-312]
-----------------------------------------------------------------
E
--
D
--------
L
K
D
L
G
E
---------
N
---
K
M
V
------
I
M
A
V
K
R
I
R
S
T
--------------------------
C
P
Y
I
V
Q
F
Y
--------
C
W
I
C
M
E
--
L
M
-
S
T
S
F
D
----
K
F
Y
K
-
Y
--
V
-
Y
S
VLDDV
I
P
E
E
I
L
G
K
I
T
L
A
T
V
K
A
L
N
H
L
K
E
N
L
K
------
K
P
S
N
I
L
L
D
R
S
G
N
I
K
L
C
D
F
--------------------------------------------------------------------
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
F
--------------------------------------------------------------
P
P
Q
L
-
S
N
-
S
EER
E
-
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
A
--------
450
Blastp_CBE
29.58
33%
-47
- C2 -
-
1PYE
1
CDK2_HUMAN
A:
[2-204]
-----------------------------------------------------------------
E
--
N
--------
F
Q
K
V
E
K
I
G
E
---
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
-----------
T
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
E
--
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
---------------------
V
--
V
-
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
28.38
34%
13
- C2 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[24-237]
---------------------------------------------------------------
K
A
D
PS
H
--------
F
E
L
L
K
V
L
G
Q
G
S
F
G
K
V
F
LVR
K
V
T
R
P
D
S
G
H
L
Y
A
M
K
V
L
-------------------
I
-
L
---
A
D
V
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
--
F
L
R
G
G
D
L
F
----
T
R
L
S
-
K
--
E
-
V
M
-----
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
L
-
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
G
H
I
K
L
T
D
F
G
L
S
---
K
E
-----------------
G
T
V
E
Y
M
A
P
-----
E
----
V
----
V
-----
N
-----
R
Q
-
G
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
G
K
D
R
K
E
-----------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
27.01
33%
-28
- C2 -
-
4D1Z
1
CDK2_HUMAN
A:
[3-204]
--------------------------------------------------------------------
N
--------
F
Q
K
V
E
K
I
G
----
G
V
V
Y
---
K
A
R
N
K
L
T
G
E
V
V
A
L
K
K
I
------------
A
I
R
-
E
I
S
L
-
L
---
K
E
L
N
H
P
N
I
V
K
L
L
D
V
I
H
T
--
K
L
Y
L
V
F
E
FL
H
Q
D
L
K
K
F
M
----
D
A
S
A
-
L
--
T
-
G
------
I
P
L
P
L
I
K
S
Y
L
F
Q
L
L
Q
G
L
A
F
C
-
H
S
H
R
V
L
H
R
D
L
K
P
Q
N
L
L
I
N
T
E
G
A
I
K
L
A
D
F
G
-------------------------
T
L
W
Y
R
A
P
-----
E
----
I
----
L
-----
L
-----
G
C
K
Y
Y
S
T
A
V
D
I
W
S
L
G
C
I
F
A
E
M
V
T
R
R
A
L
F
P
-----------------------------------------------------------------------------------------------------------------------------------------