@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MP2K4_HUMAN: (2020-09-16 )
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGKRKALKLNFANPPFKSTARFTLNPNPTGVQNPHIERLRTHSIESSGKLKISPEQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFILMYEERAVEVACYVCKILDQMPATPSSPMYVD
Atome Classification :
(110 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130..-.....140.-......150.......160.......170.......----------180..-.--....-.190...---...---.200----........210.-----......220.......230......---.240.......250..-...-..260.--.--.....-270....-...-280..-......290.......300..---....-------------.310-----------------.....--...320.----.-.....330.-----......340.......350.......360.......370.......380....-...390.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHP
A
V
S
S
M
QGK
R
K
A
L
K
L
NFANPPFKS
T
A
R
F
T
LNPNPTGVQNP
H
I
E
R
L
R
THSIESS
G
K
L
K
ISPEQHWDF
T
A
E
D
L
K
D
L
G
E
IGRGAYG
S
V
N
K
M
V
HKPSG
Q
I
M
A
V
K
R
I
R
-
S
TV
D
E
K
E
Q
K
-
Q
L
L
M
D
L
D
V
VMRSSDC
P
Y
I
V
Q
F
Y
G
A
L
FREG
D
C
W
I
C
M
E
----------
L
M
-ST-
S
--
F
D
K
F
-
Y
K
Y
V
Y
S
V
---
L
D
D
---V
I
P
-----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
I
I
H
RDIKPS
N
I
L
L
D---RSG
N
I
K
L
C
DFGI
S
G
Q
L
-
V
D
S
-
I
A
K
TRD--A--GCRPY-MAPERID-PSA-SR-QG-Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
LATGR---FPYP-------------
K
W
N
------------------
S
V
F
D
Q
--
L
T
Q
V
VKG----D-PPQLSNS
E
E
-----REF
S
P
S
F
I
N
F
V
N
L
CLTKDESKR
P
K
Y
K
E
L
L
KHP
F
I
L
M
Y
EER
A
V
E
V
A
C
Y
V
C
K
I
L
D
-QMPATPSSPMYVD
316
HHSearch
94.33
100%
-137
- C1 -
-
3ALO
1
MP2K4_HUMAN
A:
[17-311]
----------------------------------------------------------------------------------------------
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
-
S
T
V
D
E
K
E
Q
K
-
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
----------
L
M
-
S
T
-
S
--
F
D
K
F
-
Y
K
Y
V
Y
S
V
---
L
D
D
---
V
I
P
-----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
---
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
-
V
D
S
-
I
A
K
T
R
D
--
A
--
G
C
R
P
Y
-
M
A
P
E
R
I
D
-
P
---------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
---
F
P
Y
P
-------------
K
W
N
------------------
S
V
F
D
Q
--
L
T
Q
V
V
K
G
----
D
-
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
----------
2
PsiBlast_PDB
94.33
100%
-137
- C1 -
-
3ALO
1
MP2K4_HUMAN
A:
[17-311]
----------------------------------------------------------------------------------------------
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
-
S
T
V
D
E
K
E
Q
K
-
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
----------
L
M
-
S
T
-
S
--
F
D
K
F
-
Y
K
Y
V
Y
S
V
---
L
D
D
---
V
I
P
-----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
---
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
-
V
D
S
-
I
A
K
T
R
D
--
A
--
G
C
R
P
Y
-
M
A
P
E
R
I
D
-
P
---------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
---
F
P
Y
P
-------------
K
W
N
------------------
S
V
F
D
Q
--
L
T
Q
V
V
K
G
----
D
-
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
----------
1
PsiBlast_PDB
89.35
100%
-148
- C1 -
-
3ALN
1
MP2K4_HUMAN
A:
[5-311]
----------------------------------------------------------------------------------
S
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
-
S
T
V
D
E
K
E
Q
K
-
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
----------
L
M
-
S
T
-
S
--
F
D
K
F
-
Y
K
Y
V
Y
S
V
---
L
D
D
---
V
I
P
-----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
---
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
-----------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
---
F
P
Y
P
-------------
K
W
---------------------------
T
Q
V
V
K
G
----
D
-
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
----------
317
HHSearch
88.30
100%
-148
- C1 -
-
3ALN
1
MP2K4_HUMAN
A:
[12-311]
-----------------------------------------------------------------------------------------
S
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
-
S
T
V
D
E
K
E
Q
K
-
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
----------
L
M
-
S
T
-
S
--
F
D
K
F
-
Y
K
Y
V
Y
S
V
---
L
D
D
---
V
I
P
-----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
---
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
-----------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
---
F
P
Y
P
-------------
K
W
---------------------------
T
Q
V
V
K
G
----
D
-
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
----------
22
Blastp_CBE
87.64
100%
-146
- C1 -
-
3ALN
1
MP2K4_HUMAN
B:
[6-312]
-----------------------------------------------------------------------------------
S
G
K
L
K
I
S
P
E
Q
H
W
D
F
T
A
E
D
L
K
D
L
G
E
I
G
R
G
A
Y
G
S
V
N
K
M
V
H
K
P
S
G
Q
I
M
A
V
K
R
I
R
-
S
T
V
D
E
K
E
Q
K
-
Q
L
L
M
D
L
D
V
V
M
R
S
S
D
C
P
Y
I
V
Q
F
Y
G
A
L
F
R
E
G
D
C
W
I
C
M
E
----------
L
M
-
S
T
-
S
--
F
D
K
F
-
Y
K
Y
V
Y
S
V
---
L
D
D
---
V
I
P
-----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
I
I
H
R
D
I
K
P
S
N
I
L
L
D
---
R
S
G
N
I
K
L
C
D
F
G
I
S
G
Q
L
----------------------------------------
Y
D
V
R
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
---
F
P
Y
P
----------------------------------------------------
D
-
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
A
---------
4
PsiBlast_PDB
79.82
58%
-119
- C1 -
-
3VN9
1
MP2K6_HUMAN
A:
[44-332]
--------------------------------------------------------------------------------------------
Q
N
F
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
-
A
T
V
N
S
Q
E
Q
K
-
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
----------
L
M
-
D
T
-
S
--
L
D
K
F
-
Y
K
Q
V
I
D
K
----
G
Q
---
T
I
P
-----
E
D
I
L
G
K
I
A
V
S
I
V
-----
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
---
A
L
G
Q
V
K
M
C
D
F
G
I
S
G
Y
L
-
V
D
S
-
V
A
K
T
I
D
--
A
--
G
C
K
P
Y
-
M
A
P
E
R
I
N
-
P
E
L
-
N
Q
-
K
G
-
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
---
F
P
Y
D
-------------
S
W
G
------------------
T
P
F
Q
Q
--
L
K
Q
V
V
E
E
----
P
-
S
P
Q
L
P
A
D
--------
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
---------------
7
PsiBlast_PDB
78.81
50%
-151
- C1 -
-
6IB2
1
MP2K7_HUMAN
A:
[12-311]
----------------------------------------------------------------------------------
Q
T
G
Y
L
T
I
G
G
-
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
-----
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
C
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
-------------------------
A
Y
-
M
A
P
E
R
I
D
--------------
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
K
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
A
-
K
T
-----------
318
HHSearch
78.70
59%
-120
- C1 -
-
3VN9
1
MP2K6_HUMAN
A:
[45-328]
---------------------------------------------------------------------------------------------
N
F
E
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
-
A
T
V
N
S
Q
E
Q
K
-
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
----------
L
M
-
D
T
-
S
--
L
D
K
F
-
Y
K
Q
V
I
D
----
K
G
Q
---
T
I
P
-----
E
D
I
L
G
K
I
A
V
S
I
V
-----
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
---
A
L
G
Q
V
K
M
C
D
F
G
I
S
G
Y
L
-
V
D
S
-
V
A
K
T
I
D
--
A
--
G
C
K
P
Y
-
M
A
P
E
R
I
N
-
P
E
L
-
N
Q
-
K
G
-
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
---
F
P
Y
D
-------------
S
W
G
------------------
T
P
F
Q
Q
--
L
K
Q
V
V
E
E
----
P
-
S
P
Q
L
---
P
A
-----
D
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
-------------------
11
PsiBlast_PDB
78.28
50%
-80
- C1 -
-
6IB0
2
MP2K7_HUMAN
A:
[11-310]
---------------------------------------------------------------------------------
K
Q
T
G
Y
L
T
I
G
G
-
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
C
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
R
--------------
A
--
G
C
A
A
Y
-
M
A
P
E
R
I
D
P
P
D
P
-
T
K
-
P
D
-
Y
D
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
A
-
K
------------
12
PsiBlast_PDB
76.65
50%
-79
- C1 -
-
6QFL
-
MP2K7_HUMAN
A:
[12-312]
----------------------------------------------------------------------------------
Q
T
G
Y
L
T
I
G
G
-
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
C
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
R
L
-------------
A
--
G
C
A
A
Y
-
M
A
P
E
R
I
D
P-------
P
D
-
Y
D
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
A
-
K
T
E
----------
13
PsiBlast_PDB
76.35
50%
-140
- C1 -
-
6QFR
-
MP2K7_HUMAN
A:
[12-312]
----------------------------------------------------------------------------------
Q
T
G
Y
L
T
I
G
G
-
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
------
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
C
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
---------------------
A
Y
-
M
A
P
E
R
I
--------------
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
A
-
K
T
E
----------
9
PsiBlast_PDB
75.57
52%
-78
- C1 -
-
5B2L
3
MP2K7_HUMAN
A:
[10-297]
--------------------------------------------------------------------------------------------
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
S
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
------------------
G
C
A
A
Y
-
M
A
P
E
R
I
D
P
P
D
P
-
T
K
-
P
D
-
Y
D
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
---------------
18
PsiBlast_PDB
75.24
50%
-83
- C1 -
-
6QHR
1
MP2K7_HUMAN
A:
[11-311]
---------------------------------------------------------------------------------
K
Q
T
G
Y
L
T
I
G
G
-
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
C
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
R
L
-------------
A
--
G
C
A
A
Y
-
M
A
P
E
R
I
D
P
P
---------
Y
D
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
A
-
K
T
-----------
323
HHSearch
75.19
52%
-76
- C1 -
-
5Y90
4
MP2K7_HUMAN
A:
[10-318]
---------------------------------------------------------------------------------------------
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
S
--
A
E
K
L
-
K
K
R
M
-------
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
---------------
A
--
G
C
A
A
Y
-
M
A
P
E
R
I
D
-
P
P
D
P
T
K
-
P
D
-
Y
D
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
--
G
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
A
-
K
T
E
S
P
R
T
------
17
PsiBlast_PDB
74.93
50%
-90
- C1 -
-
6QHO
1
MP2K7_HUMAN
A:
[12-311]
----------------------------------------------------------------------------------
Q
T
G
Y
L
T
I
G
G
-
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
C
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
R
---------------------
Y
-
M
A
P
E
R
I
D
P-------------
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
A
-
K
T
-----------
16
PsiBlast_PDB
74.77
50%
-84
- C1 -
-
6QG7
1
MP2K7_HUMAN
A:
[12-311]
----------------------------------------------------------------------------------
Q
T
G
Y
L
T
I
G
G
-
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
C
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
R
L
-------------
A
--
G
C
A
A
Y
-
M
A
P
E
R
I
D
P------------
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
A
-
K
T
-----------
14
PsiBlast_PDB
73.93
50%
-89
- C1 -
-
6QFT
1
MP2K7_HUMAN
A:
[12-310]
----------------------------------------------------------------------------------
Q
T
G
Y
L
T
I
-
G
-
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
C
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
R
------------------
C
A
A
Y
-
M
A
P
E
R
I
D
P-------------
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
A
-
K
------------
5
PsiBlast_PDB
73.88
58%
-134
- C1 -
-
3FME
1
MP2K6_HUMAN
A:
[6-288]
--------------------------------------------------------------------------------------------------
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
----
N
S
Q
E
Q
K
-
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
----------
L
M
-
D
T
-
S
--
L
D
K
F
-
Y
K
Q
V
I
D
K
----
G
Q
---
T
I
P
-----
E
D
I
L
G
K
I
A
V
S
I
V
-----
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
---
A
L
G
Q
V
K
M
C
D
F
-------------------
A
--
G
C
K
P
Y
-
M
A
P
E
R
I
N
-
P
E
L
-
N
Q
----
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
---
F
P
Y
D
-------------
S
W
G
------------------
T
P
F
Q
Q
--
L
K
Q
V
V
E
E
----
P
-
S
P
Q
L
P
A
D
--------
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
S
F
V
K
L
I
L
---------------
319
HHSearch
73.69
59%
-132
- C1 -
-
3FME
1
MP2K6_HUMAN
A:
[4-281]
------------------------------------------------------------------------------------------------
V
K
A
D
D
L
E
P
I
M
E
L
G
R
G
A
Y
G
V
V
E
K
M
R
H
V
P
S
G
Q
I
M
A
V
K
R
I
R
----
N
S
Q
E
Q
K
-
R
L
L
M
D
L
D
I
S
M
R
T
V
D
C
P
F
T
V
T
F
Y
G
A
L
F
R
E
G
D
V
W
I
C
M
E
----------
L
M
-
D
T
-
S
--
L
D
K
F
-
Y
K
Q
V
I
D
----
K
G
Q
---
T
I
P
-----
E
D
I
L
G
K
I
A
V
S
I
V
-----
K
A
L
E
H
L
H
S
K
L
S
V
I
H
R
D
V
K
P
S
N
V
L
I
N
---
A
L
G
Q
V
K
M
C
D
F
-------------------
A
--
G
C
K
P
Y
-
M
A
P
E
R
I
N
-
P
E
L
-
N
Q
----
Y
S
V
K
S
D
I
W
S
L
G
I
T
M
I
E
L
A
I
L
R
---
F
P
Y
D
-------------
S
W
G
------------------
T
P
F
Q
Q
--
L
K
Q
V
V
E
E
----
P
-
S
P
Q
L
---
P
A
-----
D
K
F
S
A
E
F
V
D
F
T
S
Q
C
L
K
K
N
S
K
E
R
P
T
Y
P
E
L
M
Q
H
P
F
F
T
L
H
E
S
K
G
T
D
V
A
----------------------
8
PsiBlast_PDB
73.51
52%
-78
- C1 -
-
5Y90
4
MP2K7_HUMAN
A:
[9-299]
--------------------------------------------------------------------------------------------
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
G
S
G
T
C
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
S
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
---------------
A
--
G
C
A
A
Y
-
M
A
P
E
R
I
D
P
P
D
P
-
T
K
-
P
D
-
Y
D
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
---------------
15
PsiBlast_PDB
73.21
50%
-88
- C1 -
-
6QG4
1
MP2K7_HUMAN
A:
[12-311]
----------------------------------------------------------------------------------
Q
T
G
Y
L
T
I
-
G
-
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
-----
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
C
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
R
-------------------
A
A
Y
-
M
A
P
E
R
I
D
P------------
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
A
-
K
T
-----------
10
PsiBlast_PDB
72.28
52%
-84
- C1 -
-
5Z1E
1
MP2K7_HUMAN
A:
[10-298]
--------------------------------------------------------------------------------------------
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
-----
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
S
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
C
D
F
G
I
S
G
------------------
G
C
A
A
Y
-
M
A
P
E
R
I
D
P
P
D
P
-
T
------
D
I
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
---------------
26
Blastp_CBE
70.17
52%
-80
- C1 -
-
5Z1D
2
MP2K7_HUMAN
A:
[10-297]
--------------------------------------------------------------------------------------------
Q
R
Y
Q
A
E
I
N
D
L
E
N
L
G
E
M
-----
G
Q
V
W
K
M
R
F
R
K
T
G
H
V
I
A
V
K
Q
M
R
-
R
S
G
N
K
E
E
N
K
-
R
I
L
M
D
L
D
V
V
L
K
S
H
D
C
P
Y
I
V
Q
C
F
G
T
F
I
T
N
T
D
V
F
I
A
M
E
----------
L
M
-
G
T
-
C
--
A
E
K
L
-
K
K
R
-------
M
Q
G
---
P
I
P
-----
E
R
I
L
G
K
M
T
V
A
I
V
-----
K
A
L
Y
Y
L
K
E
K
H
G
V
I
H
R
D
V
K
P
S
N
I
L
L
D
---
E
R
G
Q
I
K
L
S
D
F
G
I
S
-------------------
G
C
A
A
Y
-
M
A
P
E
R
I
D
P
P
------------
R
A
D
V
W
S
L
G
I
S
L
V
E
L
A
T
G
Q
---
F
P
Y
K
-------------
N
C
K
------------------
T
D
F
E
V
--
L
T
K
V
L
Q
E
----
E
-
P
P
L
L
P
G
--
H
-----
M
G
F
S
G
D
F
Q
S
F
V
K
D
C
L
T
K
D
H
R
K
R
P
K
Y
N
K
L
L
E
H
S
F
I
K
R
Y
E
T
L
E
V
D
V
A
S
W
F
K
D
V
M
---------------
63
Blastp_CBE
67.96
36%
-46
- C1 -
-
3EQD
1
MP2K1_HUMAN
A:
[29-349]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
PPDAKELELMFGC---PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
59
Blastp_CBE
67.54
36%
-48
- C1 -
-
3EQI
1
MP2K1_HUMAN
A:
[29-349]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
PPDAKELELMFGC---PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
28
Blastp_CBE
67.48
40%
-54
- C1 -
-
4AN9
2
MP2K1_HUMAN
A:
[5-282]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
E
-
M
A
-
N
E
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
R
P
-------------
P
M
-------------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
75
Blastp_CBE
67.34
36%
-41
- C1 -
-
5BX0
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFGCPM------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
33
Blastp_CBE
67.33
39%
-39
- C1 -
-
3ORN
3
MP2K1_HUMAN
A:
[2-288]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
--PPM---------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
--------------
48
Blastp_CBE
67.04
36%
-50
- C1 -
-
4LMN
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
74
Blastp_CBE
66.64
36%
-44
- C1 -
-
3MBL
2
MP2K1_HUMAN
A:
[2-319]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPM--------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
67
Blastp_CBE
66.56
35%
-35
- C1 -
-
6PP9
5
?
B:
[66-387]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
A
-
M
A
N
A
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMPM---------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
-----------
73
Blastp_CBE
66.49
36%
-41
- C1 -
-
3PP1
1
MP2K1_HUMAN
A:
[2-319]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPM--------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
38
Blastp_CBE
66.44
36%
-51
- C1 -
-
3EQB
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
58
Blastp_CBE
66.42
36%
-31
- C1 -
-
6U2G
2
MP2K1_HUMAN
A:
[63-384]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMPM---------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
-----------
60
Blastp_CBE
66.20
36%
-48
- C1 -
-
3EQH
2
MP2K1_HUMAN
A:
[29-348]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
PPDAKELELMFGC---PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
29
Blastp_CBE
66.17
40%
-54
- C1 -
-
4AN3
2
MP2K1_HUMAN
A:
[5-282]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
E
-
M
A
-
N
E
------
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
R
P
-------------
P
M
-------------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
54
Blastp_CBE
66.10
36%
-51
- C1 -
-
3V01
2
?
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
61
Blastp_CBE
66.09
36%
-47
- C1 -
-
3EQG
2
MP2K1_HUMAN
A:
[29-348]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
PPDAKELELMFGC---PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
27
Blastp_CBE
66.07
40%
-54
- C1 -
-
4ANB
2
MP2K1_HUMAN
A:
[5-282]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
E
-
M
A
-
N
E
F
--
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
R
P
-------------
P
M
-------------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
31
Blastp_CBE
66.02
39%
-41
- C1 -
-
3WIG
3
MP2K1_HUMAN
A:
[2-288]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
---
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
-PPM---------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
--------------
49
Blastp_CBE
65.81
36%
-44
- C1 -
-
4ARK
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPM--------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
71
Blastp_CBE
65.72
35%
-44
- C1 -
-
6NYB
2
?
B:
[84-405]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
A
-
M
A
N
A
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
Q
-----------
55
Blastp_CBE
65.71
36%
-43
- C1 -
-
3E8N
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
----
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
53
Blastp_CBE
65.63
36%
-49
- C1 -
-
3V04
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
62
Blastp_CBE
65.61
36%
-40
- C1 -
-
3EQF
1
MP2K1_HUMAN
A:
[29-348]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
PPDAKELELMFGC---PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
80
Blastp_CBE
65.57
36%
-54
- C1 -
-
5HZE
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
----
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
PPDAKELELMF-----PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
69
Blastp_CBE
65.52
35%
-52
- C1 -
-
6Q0J
2
?
D:
[84-401]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
A
-
M
A
N
A
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMPPM--------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
30
Blastp_CBE
65.48
40%
-50
- C1 -
-
4AN2
2
MP2K1_HUMAN
A:
[5-282]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
E
-
M
A
-
N
E
F
--
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
R
P
-------------
P
M
-------------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
78
Blastp_CBE
65.46
36%
-36
- C1 -
-
3ZLS
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFGCPM------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
42
Blastp_CBE
65.46
36%
-52
- C1 -
-
4U80
2
MP2K1_HUMAN
A:
[6-319]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
52
Blastp_CBE
65.45
36%
-47
- C1 -
-
3VVH
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
----------
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
57
Blastp_CBE
65.32
36%
-49
- C1 -
-
1S9J
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
39
Blastp_CBE
65.32
36%
-47
- C1 -
-
2P55
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
41
Blastp_CBE
65.22
36%
-50
- C1 -
-
4U81
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
72
Blastp_CBE
65.19
36%
-47
- C1 -
-
3DV3
3
MP2K1_HUMAN
A:
[2-319]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
--------
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPM--------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
37
Blastp_CBE
65.18
37%
-34
- C1 -
-
1S9I
2
MP2K2_HUMAN
A:
[12-339]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
R
I
S
E
L
G
A
G
N
G
G
V
V
T
K
V
Q
H
R
P
S
G
L
I
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
E
A
K
R
-----------
I
P
-----
E
E
I
L
G
K
V
S
I
A
V
L
-----
R
G
L
A
Y
L
R
E
K
H
Q
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
-------
V
--
G
T
R
S
Y
-
M
A
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
L
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELEAIFGRPVVDRPAM
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
N
G
--------
V
F
T
P
D
F
Q
E
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
M
L
T
N
H
T
F
I
K
R
S
E
V
E
E
V
D
F
A
G
W
L
C
K
T
L
R
L
N
Q
P
G
---------
70
Blastp_CBE
65.15
35%
-51
- C1 -
-
6Q0J
2
?
C:
[84-401]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
A
-
M
A
N
A
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMPPM--------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
68
Blastp_CBE
65.13
35%
-49
- C1 -
-
6Q0T
2
?
C:
[84-401]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
A
-
M
A
N
A
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMPPM--------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
51
Blastp_CBE
65.05
36%
-32
- C1 -
-
3VVH
2
?
B:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFM---------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
50
Blastp_CBE
64.95
36%
-44
- C1 -
-
3VVH
2
?
C:
[6-321]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
APM---------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
43
Blastp_CBE
64.94
36%
-45
- C1 -
-
4U7Z
2
MP2K1_HUMAN
A:
[6-322]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
----
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFPPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
82
Blastp_CBE
64.84
36%
-54
- C1 -
-
3ZLW
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
A
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
-
D
G
G
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
PPDAKELELMFGC---PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
64
Blastp_CBE
64.80
36%
-44
- C1 -
-
3EQC
2
MP2K1_HUMAN
A:
[29-349]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
PPDAKELELMFGC---PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L
N
------------
79
Blastp_CBE
64.71
36%
-44
- C1 -
-
3ZLY
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
-
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFGCPM------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
77
Blastp_CBE
64.57
36%
-42
- C1 -
-
3ZLX
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFGCPM------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
76
Blastp_CBE
64.47
36%
-51
- C1 -
-
3ZM4
1
MP2K1_HUMAN
A:
[27-344]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
---------
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFGCPM------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
-
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
81
Blastp_CBE
64.40
36%
-51
- C1 -
-
3W8Q
1
MP2K1_HUMAN
A:
[24-341]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFGCQRPPM---
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
32
Blastp_CBE
63.66
39%
-53
- C1 -
-
3OS3
2
MP2K1_HUMAN
A:
[2-286]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
-----------------PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
----------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
----------------
21
Blastp_CBE
63.21
100%
-168
- C1 -
-
3ALN
1
MP2K4_HUMAN
C:
[22-312]
---------------------------------------------------------------------------------------------------
E
D
L
K
D
L
G
E
---------
N
K
M
V
------
I
M
A
V
K
R
I
R
-
S
T
----------------------
C
P
Y
I
V
Q
F
Y
--------
C
W
I
C
M
E
----------
L
M
-
S
T
-
S
--
F
D
K
F
-
Y
K
Y
V
Y
S
V
---
L
D
D
---
V
I
P
-----
E
E
I
L
G
K
I
T
L
A
T
V
-----
K
A
L
N
H
L
K
E
N
L
K
------
K
P
S
N
I
L
L
D
---
R
S
G
N
I
K
L
C
D
F
--------------------------------------------------
S
D
V
W
S
L
G
I
T
L
Y
E
L
A
T
G
R
---
F
---------------------------------------------------------
P
P
Q
L
S
N
S
E
E
-----
R
E
F
S
P
S
F
I
N
F
V
N
L
C
L
T
K
D
E
S
K
R
P
K
Y
K
E
L
L
K
H
P
F
I
L
M
Y
E
E
R
A
V
E
V
A
C
Y
V
C
K
I
L
D
-
Q
M
P
A
---------
36
Blastp_CBE
63.07
37%
-44
- C1 -
-
1S9I
2
MP2K2_HUMAN
B:
[12-335]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
R
I
S
E
L
G
A
G
N
G
G
V
V
T
K
V
Q
H
R
P
S
G
L
I
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
E
A
K
R
-----------
I
P
-----
E
E
I
L
G
K
V
S
I
A
V
L
-----
R
G
L
A
Y
L
R
E
K
H
Q
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
-----------
T
R
S
Y
-
M
A
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
L
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELEAIFGRM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
N
G
--------
V
F
T
P
D
F
Q
E
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
M
L
T
N
H
T
F
I
K
R
S
E
V
E
E
V
D
F
A
G
W
L
C
K
T
L
R
L-------------
40
Blastp_CBE
62.87
36%
-42
- C1 -
-
2Y4I
1
MP2K1_RABIT
C:
[64-383]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
---
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
S
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFGCPM------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
A
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
35
Blastp_CBE
62.86
41%
-44
- C1 -
-
3SLS
2
MP2K1_HUMAN
A:
[25-300]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
-------
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
G
----------------------------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
66
Blastp_CBE
62.48
36%
-61
- C1 -
-
5EYM
1
MP2K1_HUMAN
A:
[28-347]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
---
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
---
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
-----------
T
R
S
Y
-
M
S
P
E
R
L
--------------
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
PPDAKELELMF-----PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
85
Blastp_CBE
62.42
36%
-41
- C1 -
-
5YT3
1
?
B:
[24-341]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
-
D
G
G
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
D
-
M
A
N
D
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFG---------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
83
Blastp_CBE
62.30
36%
-64
- C1 -
-
5YT3
1
?
D:
[24-341]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
--
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
-
D
G
G
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
D
-
M
A
N
D
F
---
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMF----------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
65
Blastp_CBE
61.50
36%
-61
- C1 -
-
5EYM
1
?
B:
[28-347]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
---
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
---
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
-----------
T
R
S
Y
-
M
S
P
E
R
L
--------------
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
PPDAKELELMF-----PM----------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
G
L-------------
34
Blastp_CBE
61.49
41%
-39
- C1 -
-
3SLS
2
MP2K1_HUMAN
B:
[25-300]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
----------
V
--
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
--------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
-----------------GSM---------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
56
Blastp_CBE
61.06
36%
-43
- C1 -
-
3DY7
2
MP2K1_HUMAN
A:
[6-304]
---------------------------------------------------------------------------------------------------
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
D
G
G
-
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
S
G
Q
L
-
I
D
S
-
M
A
N
--------
G
T
R
S
Y
-
M
S
P
E
R
L
Q
-
G
T
H
-------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
--PPM---------------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
------------------------------
86
Blastp_CBE
59.70
36%
-61
- C1 -
-
5YT3
1
MP2K1_HUMAN
A:
[24-341]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
-
L
E
I
K
P
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
-
D
G
G
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
V
---------------------
T
R
S
Y
-
M
S
P
E
R
L
Q
-----------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFGPM-------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
84
Blastp_CBE
58.73
36%
-43
- C1 -
-
5YT3
1
?
C:
[24-341]
-----------------------------------------------------------------------------------------------
E
L
K
D
D
D
F
E
K
I
S
E
L
G
A
G
N
G
G
V
V
F
K
V
S
H
K
P
S
G
L
V
M
A
R
K
L
I
H
------
A
I
R
N
-
Q
I
I
R
E
L
Q
V
-
L
H
E
C
N
S
P
Y
I
V
G
F
Y
G
A
F
Y
S
D
G
E
I
S
I
C
M
E
----------
H
M
-
D
G
G
S
--
L
D
Q
V
-
L
K
K
A
G
R
-----------
I
P
-----
E
Q
I
L
G
K
V
S
I
A
V
I
-----
K
G
L
T
Y
L
R
E
K
H
K
I
M
H
R
D
V
K
P
S
N
I
L
V
N
---
S
R
G
E
I
K
L
C
D
F
G
------------------------
S
Y
-
M
S
P
E
R
L
------------
Y
S
V
Q
S
D
I
W
S
M
G
L
S
L
V
E
M
A
V
G
R
---
Y
P
I
P
-------------
P
P
D
AKELELMFGCPM------
A
I
F
E
L
--
L
D
Y
I
V
N
E
----
P
-
P
P
K
L
P
S
G
--------
V
F
S
L
E
F
Q
D
F
V
N
K
C
L
I
K
N
P
A
E
R
A
D
L
K
Q
L
M
V
H
A
F
I
K
R
S
D
A
E
E
V
D
F
A
G
W
L
C
S
T
I
---------------
173
Blastp_CBE
57.14
32%
-38
- C1 -
-
6EIM
5
STK10_HUMAN
A:
[15-279]
----------------------------------------------------------------------------------------
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
------
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
T
K
S
E
E
E
L
E
-
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
----------
F
C
P
G
G
-
A
--
V
D
A
-----
I
M
L
E
---
L
D
R
---
G
L
T
-----
E
P
Q
I
Q
V
V
C
R
Q
M
L
-----
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
---
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
-
L
K
T
-
L
Q
K
-
R
D
--
S
FI
G
T
P
Y
W
-
M
A
P
E
V
V
M
-
C
E
T
-
M
K
-
D
T
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
---
P
P
H
H
-------------
E
L
N
------------------
P
M
-
R
V
--
L
L
A
I
A
A
S
----
D
-
P
P
T
L
L
T
P
S
-------
K
W
S
V
E
F
R
D
F
L
A
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
---------------------------------
151
Blastp_CBE
54.75
33%
-41
- C1 -
-
6HXF
4
STK10_HUMAN
D:
[15-279]
----------------------------------------------------------------------------------------
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
T
K
S
E
E
E
L
E
-
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
----------
F
C
P
G
G
-
A
--
V
D
A
-----
I
M
L
E
---
L
D
R
---
G
L
T
-----
E
P
Q
I
Q
V
V
C
R
Q
M
L
-----
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
---
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
-
L
K
T
--
L
Q
K
R
D
--
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
-
C
E
M
----
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
---
P
P
H
H
-------------
E
L
N
------------------
P
M
-
R
V
--
L
L
K
I
A
K
S
----
D
-
P
P
T
L
L
T
P
S
-------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
---------------------------------
131
Blastp_CBE
54.46
34%
-76
- C1 -
-
2JFL
6
SLK_HUMAN
A:
[33-297]
----------------------------------------------------------------------------------------
L
N
P
E
D
F
W
E
I
-------
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
-
V
L
A
A
A
K
V
I
-
D
T
K
S
E
E
E
L
E
-
D
Y
M
V
E
I
D
I
-
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
Y
Y
E
N
N
L
W
I
L
I
E
----------
F
C
-
A
G
-
G
--
A
----
V
D
A
V
M
L
E
---
L
E
R
---
P
L
T
-----
E
S
Q
I
Q
V
V
C
K
Q
T
L
-----
D
A
L
N
Y
L
H
D
N
-
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
---
L
D
G
D
I
K
L
A
D
F
G
V
S
A
K
---
N
T
-
R
I
Q
R
R
D
--
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
-
C
E
T
-
S
K
D
R
P
-
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
---
P
P
H
H
-------------
E
L
N
------------------
P
M
-
R
V
--
L
L
K
I
A
K
S
----
E
-
P
P
T
L
--
A
Q
P
-----
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
V
---------------------------------
135
Blastp_CBE
53.38
33%
-13
- C1 -
-
4FZA
3
STK26_HUMAN
B:
[8-277]
---------------------------------------------------------------------------------------------------
E
L
F
T
K
L
E
R
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
I
I
D
-
L
E
E
A
E
D
E
I
E
-
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
K
G
S
K
L
W
I
I
M
E
YLGGGSALDL
L
R
-
A
G
-
P
--
F
D
E
F
-
Q
--
I
A
T
M
---
L
K
E
---
I
L
-----------------------
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
---
E
Q
G
D
V
K
L
A
A
F
G
V
A
G
Q
L
-
T
D
T
Q
I
K
R
N
T
F
--
V
--
G
T
P
F
W
-
M
A
P
E
V
I
Q
-
Q
S
A
-------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
---
P
P
N
S
-------------
D
M
H
------------------
P
M
-
R
V
--
L
F
L
I
P
K
N
----
N
-
P
P
T
L
V
G
---------
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
V
K
N
S
K
K
----
T
S
Y
L
T
E
L
I
D
-
R
F
-----------
153
Blastp_CBE
52.08
33%
-29
- C1 -
-
6HXF
5
STK10_HUMAN
B:
[15-279]
----------------------------------------------------------------------------------------
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
T
K
S
E
E
E
L
E
-
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
----------
F
C
P
G
G
-
A
--
V
D
A
-----
I
M
L
E
---
L
D
R
---
G
L
T
-----
E
P
Q
I
Q
V
V
C
R
Q
M
L
-----
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
---
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
-
L
K
T
--
L
Q
K
R
D
--
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
-
C
E
M
-
K
D
-
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
---
P
P
H
H
-------------
E
L
N
------------------
P
M
-
R
V
--
L
L
K
I
A
K
S
----
D
-
P
P
T
L
L
T
P
S
-------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
---------------------------------
181
Blastp_CBE
51.82
31%
-30
- C1 -
-
2VWI
1
OXSR1_HUMAN
D:
[10-291]
----------------------------------------------------------------------------------------------
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
-
L
E
K
C
Q
T
S
M
D
-
E
L
L
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
G
G
S
--
V
L
D
I
-
I
K
H
I
V
A
K
---
G
E
H
KSG
V
L
D
-----
E
S
T
I
A
T
I
L
R
E
V
L
-----
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
-
A
T
G
-
G
-----TF
V
--
G
T
P
C
W
-
M
A
P
E
V
M
E
-
Q
V
-----
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
---
A
P
Y
H
-------------
K
Y
P
------------------
P
M
-
K
V
--
L
M
L
T
L
Q
N
----
D
-
P
P
S
L
E
T
G
V
Q
DKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
F
---------------------------------
117
Blastp_CBE
51.67
35%
-3
- C1 -
-
4W8D
1
STK24_HUMAN
A:
[8-282]
--------------------------------------------------------------------------------------
L
K
A
D
P
E
-------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
-
L
E
E
A
E
D
E
I
E
-
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
----------
Y
L
-
G
G
-
G
------------
S
A
---
L
D
L
---
L
E
P
GPLD-
E
T
Q
I
A
T
I
L
R
E
I
L
-----
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
---
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
-
Q
I
K
R
N
F
--
V
--
G
T
P
F
W
-
M
A
P
E
V
I
K
-
Q
S
A
-------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
---
P
P
H
S
-------------
E
L
H
------------------
P
M
-
K
V
--
L
F
L
I
P
K
N
----
N
-
P
P
T
L
----
E
-----
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
----
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
-
R
------------
152
Blastp_CBE
51.36
33%
-32
* C1 *
-
6HXF
2
STK10_HUMAN
C:
[15-279]
----------------------------------------------------------------------------------------
L
D
P
N
E
V
W
E
I
-------
V
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
--
E
T
K
-
E
E
E
L
E
-
D
Y
I
V
E
I
E
I
-
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
H
D
G
K
L
W
I
M
I
E
----------
F
C
P
G
G
-
A
--
V
D
A
-----
I
M
L
E
---
L
D
R
---
G
L
T
-----
E
P
Q
I
Q
V
V
C
R
Q
M
L
-----
E
A
L
N
F
L
H
S
K
-
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
---
L
E
G
D
I
R
L
A
D
F
G
V
S
A
K
N
-
L
K
T
--
L
Q
K
R
D
--
F
--
I
G
T
P
Y
W
M
A
P
E
V
V
M
-
C
E
M
-
K
D
-
T
P
-
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
---
P
P
H
H
-------------
E
L
N
------------------
P
M
-
R
V
--
L
L
K
I
A
K
S
----
D
-
P
P
T
L
L
T
P
S
-------
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
V
---------------------------------
118
Blastp_CBE
51.36
35%
-4
- C1 -
-
4U8Z
1
STK24_HUMAN
A:
[8-282]
--------------------------------------------------------------------------------------
L
K
A
D
P
E
-------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
-
L
E
E
A
E
D
E
I
E
-
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
----------
Y
L
-
G
G
-
G
------------
S
A
---
L
D
L
---
L
E
P
GPLD-
E
T
Q
I
A
T
I
L
R
E
I
L
-----
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
---
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
-
Q
I
K
R
N
F
--
V
--
G
T
P
F
W
-
M
A
P
E
V
I
K
-
Q
S
A
-------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
---
P
P
H
S
-------------
E
L
H
------------------
P
M
-
K
V
--
L
F
L
I
P
K
N
----
N
-
P
P
T
L
----
E
-----
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
----
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
-
R
------------
174
Blastp_CBE
51.24
33%
-21
- C1 -
-
5D9H
1
STK39_MOUSE
B:
[26-294]
-----------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
-
L
E
K
C
Q
T
S
M
D
-
E
L
L
K
E
I
Q
A
M
S
Q
C
S
H
-
P
N
V
V
T
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
G
G
S
--
M
L
D
I
-
I
K
Y
I
V
N
R
GEH
K
N
G
---
V
L
E
-----
E
A
I
I
A
T
I
L
K
E
V
L
-----
E
G
L
D
Y
L
H
R
N
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
-
A
T
G
-
G
D
V
T
R
N
-----
G
T
P
C
W
-
M
A
P
E
V
M
E
-
Q
V
-----
R
G
-
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
---
A
P
Y
H
-------------
K
Y
P
------------------
P
M
-
K
V
--
L
M
L
T
L
Q
N
----
D
-
P
P
T
L
E
T
G
V
E
DKEMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
K
F
F
---------------------------------
178
Blastp_CBE
51.05
31%
-24
- C1 -
-
3DAK
1
OXSR1_HUMAN
B:
[5-285]
----------------------------------------------------------------------------------------------
W
S
I
N
R
D
D
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
Y
C
A
P
K
K
E
K
V
A
I
K
R
I
N
-
L
E
K
C
Q
T
S
M
D
-
E
L
L
K
E
I
Q
A
-
M
S
Q
C
H
H
P
N
I
V
S
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
G
G
S
--
V
L
D
I
-
I
K
H
I
V
A
K
---
G
E
H
KSG
V
L
D
-----
E
S
T
I
A
T
I
L
R
E
V
L
-----
E
G
L
E
Y
L
H
K
N
G
Q
I
-
H
R
D
V
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
-
A
T
G
-
G
D
----------
T
P
C
W
-
M
A
P
E
V
M
E
-
Q
V
-----
R
G
-
Y
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
---
A
P
Y
H
-------------
K
Y
P
------------------
P
M
-
K
V
--
L
M
L
T
L
Q
N
----
D
-
P
P
S
L
E
T
G
V
Q
DKEML
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
----------------------------------
111
Blastp_CBE
50.74
35%
-3
- C1 -
-
4QML
2
STK24_HUMAN
A:
[25-297]
----------------------------------------------------------------------------------------
A
D
P
E
-------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
-
L
E
E
A
E
D
E
I
E
-
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
----------
Y
L
-
G
G
-
G
------------
S
A
---
L
D
L
---
L
E
P
GPLD-
E
T
Q
I
A
T
I
L
R
E
I
L
-----
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
---
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
-
Q
I
K
R
N
F
--
V
--
G
T
P
F
W
-
M
A
P
E
V
I
K
-
Q
S
A
-------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
---
P
P
H
S
-------------
E
L
H
------------------
P
M
-
K
V
--
L
F
L
I
P
K
N
----
N
-
P
P
T
L
----
E
-----
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
----
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
-
R
------------
115
Blastp_CBE
50.54
35%
-0
- C1 -
-
3A7H
1
STK24_HUMAN
B:
[16-290]
--------------------------------------------------------------------------------------
L
K
A
D
P
E
-------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
-
L
E
E
A
E
D
E
I
E
-
D
I
Q
Q
E
I
-
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
K
D
T
K
L
W
I
I
M
E
----------
Y
L
-
G
G
-
G
------------
S
A
---
L
D
L
---
L
E
P
GPLD-
E
T
Q
I
A
T
I
L
R
E
I
L
-----
K
G
L
D
Y
L
H
S
E
K
K
I
-
H
R
D
I
K
A
A
N
V
L
L
S
---
E
H
G
E
V
K
L
A
D
F
G
V
A
G
Q
L
-
T
D
T
-
Q
I
K
R
N
F
--
V
--
G
T
P
F
W
-
M
A
P
E
V
I
K
-
Q
S
A
-------
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
---
P
P
H
S
-------------
E
L
H
------------------
P
M
-
K
V
--
L
F
L
I
P
K
N
----
N
-
P
P
T
L
----
E
-----
G
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
----
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
-
R
------------
170
Blastp_CBE
49.84
34%
-22
- C1 -
-
5DBX
1
STK39_MOUSE
B:
[19-287]
-----------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
-
L
E
K
----
M
D
-
E
L
L
K
E
I
Q
A
M
S
Q
S
H
--
P
N
V
V
T
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
G
G
S
--
M
L
D
I
-
I
K
Y
I
V
N
R
GEH
K
N
G
---
V
L
E
-----
E
A
I
I
A
T
I
L
K
E
V
L
-----
E
G
L
D
Y
L
H
R
N
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
-
A
T
G
-
G
-------
F
--
V
G
T
P
W
-
M
A
P
E
V
M
E
-
Q
V
-----
R
G
-
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
---
A
P
Y
H
-------------
K
Y
P
------------------
P
M
-
K
V
--
L
M
L
T
L
Q
N
----
D
-
P
P
T
L
E
T
G
V
E
DKEMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
K
F
F
----------------------------------
171
Blastp_CBE
49.72
34%
-29
- C1 -
-
5DBX
1
STK39_MOUSE
A:
[19-287]
-----------------------------------------------------------------------------------------------------------
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
-
L
E
K
C
Q
T
S
M
D
-
E
L
L
K
E
I
Q
A
M
S
Q
S
H
--
P
N
V
V
T
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
----------
L
L
-
S
G
G
S
--
M
L
D
I
-
I
K
Y
I
V
N
R
GEH
K
N
G
---
V
L
E
-----
E
A
I
I
A
T
I
L
K
E
V
L
-----
E
G
L
D
Y
L
H
R
N
G
Q
I
-
H
R
D
L
K
A
G
N
I
L
L
G
---
E
D
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
-
A
-----------
F
--
V
G
T
P
W
-
M
A
P
E
V
M
E
-
Q
V
-----
R
G
-
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
---
A
P
Y
H
-------------
K
Y
P
------------------
P
M
-
K
V
--
L
M
L
T
L
Q
N
----
D
-
P
P
T
L
E
T
G
V
E
DKEMM
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
K
F
F
----------------------------------
280
Blastp_CBE
48.82
32%
-18
- C1 -
-
2GCD
1
TAOK2_RAT
B:
[17-271]
-----------------------------------------------------------------------------------------------------
F
S
D
L
R
E
I
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
K
M
S
-
Y
S
G
K
Q
S
N
E
K
W
Q
D
I
I
K
E
V
R
F
L
Q
K
L
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
R
E
H
T
A
W
L
V
M
E
----------
Y
C
-
L
G
-
S
--
A
S
D
L
-
L
E
V
H
K
K
P
---
L
Q
E
---
V
--------
E
I
-
A
A
V
T
H
G
A
L
-----
Q
G
L
A
Y
L
H
S
H
-
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
---
E
P
G
L
V
K
L
G
D
F
G
S
A
S
-----
I
-
M
A
P
A
N
F
--
V
--
G
T
P
Y
W
-
M
A
P
E
V
I
L
-
A
M
D
-
E
G
-
Q
--
Y
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
---
P
P
L
F
-------------
N
M
N
------------------
A
M
-
S
A
--
L
Y
H
I
A
Q
N
----
E
-
S
P
A
L
Q
S
G
H
W
-----
S
E
Y
---
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
V
L
--------------------------------
228
Blastp_CBE
48.53
31%
-46
- C1 -
-
5XVF
1
A:
[23-274]
-----------------------------------------------------------------------------------------------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
---
D
L
R
K
Q
Q
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
----------
F
L
-
E
G
-
G
-------------
A
---
L
T
D
---
I
V
T
HTRMN
E
E
Q
I
A
A
V
C
L
A
V
L
-----
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
-
S
K
E
-
V
P
R
R
K
L
--
V
--
G
T
P
Y
W
-
M
A
P
E
L
I
------
S
R
-
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
---
P
P
Y
---------------
F
N
------------------
E
P
P
L
K
--
A
M
K
M
I
R
D
----
N
L
P
P
R
L
K
N
L
H
-------
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
---------------------------------
222
Blastp_CBE
48.46
33%
-21
- C1 -
-
4ZY4
2
PAK1_HUMAN
B:
[28-274]
----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
---
N
L
-
Q
Q
P
K
K
-
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
G
-
G
-------------
S
---
L
T
D
---
V
V
T
-----
E
T
C
M
D
E
G
Q
I
A
A
V
CRECL
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
-
T
P
E
-
Q
S
K
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
---
P
P
Y
L
-------------
N
E
N
------------------
P
-
L
R
A
--
L
Y
L
I
A
T
N
----
G
-
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
---------------------------------
220
Blastp_CBE
48.44
33%
-19
- C1 -
-
4ZY5
2
PAK1_HUMAN
B:
[28-274]
----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
---
N
L
-
Q
Q
P
K
K
-
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
G
-
G
-------------
S
---
L
T
D
---
V
V
T
-----
E
T
C
M
D
E
G
Q
I
A
A
V
CRECL
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
-
T
P
E
-
Q
S
K
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
---
P
P
Y
L
-------------
N
E
N
------------------
P
-
L
R
A
--
L
Y
L
I
A
T
N
----
G
-
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
---------------------------------
224
Blastp_CBE
48.30
31%
-49
- C1 -
-
5ZJW
10
A:
[23-274]
-----------------------------------------------------------------------------------------------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
---
D
L
R
K
Q
Q
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
----------
F
L
-
E
G
-
G
-------------
A
---
L
T
D
---
I
V
T
HTRMN
E
E
Q
I
A
A
V
C
L
A
V
L
-----
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
-
S
K
E
-
V
P
R
R
K
L
--
V
--
G
T
P
Y
W
-
M
A
P
E
L
I
------
S
R
-
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
---
P
P
Y
---------------
F
N
------------------
E
P
P
L
K
--
A
M
K
M
I
R
D
----
N
L
P
P
R
L
K
N
L
H
-------
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
---------------------------------
226
Blastp_CBE
48.26
31%
-49
- C1 -
-
5XVA
4
PAK4_HUMAN
A:
[23-274]
-----------------------------------------------------------------------------------------------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
---
D
L
R
K
Q
Q
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
----------
F
L
-
E
G
-
G
-------------
A
---
L
T
D
---
I
V
T
HTRMN
E
E
Q
I
A
A
V
C
L
A
V
L
-----
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
-
S
K
E
-
V
P
R
R
K
L
--
V
--
G
T
P
Y
W
-
M
A
P
E
L
I
------
S
R
-
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
---
P
P
Y
---------------
F
N
------------------
E
P
P
L
K
--
A
M
K
M
I
R
D
----
N
L
P
P
R
L
K
N
L
H
-------
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
---------------------------------
185
Blastp_CBE
48.13
32%
-48
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[2-275]
-------------------------------------------------------------------------------------------------
S
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
---
L
E
P
G
E
D
F
-
A
V
V
Q
Q
E
I
I
M
M
K
D
C
K
H
P
N
I
V
A
Y
F
G
S
Y
L
R
R
D
K
L
W
I
C
M
E
----------
F
C
-
G
G
-
G
--
S
L
Q
D
-
I
Y
H
V
T
G
P
---
L
S
E
---
L
Q
---------
I
A
Y
V
S
R
E
T
L
-----
Q
G
L
Y
Y
L
H
S
K
G
K
M
-
H
R
D
I
K
G
A
N
I
L
L
D
----
N
G
H
V
K
L
A
D
F
G
V
S
A
Q
I
-
T
A
T
-
I
A
K
-----
F
--
I
G
T
P
Y
W
M
A
P
E
-
V
A
-
A
V
E
-
R
K
-
G
G
-
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
PPM
F
D
L
H
-------------
P
M
R
------------------
A
L
F
----
L
M
T
K
S
N
F
----
Q
-
P
P
K
L
K
D
--
K
-----
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
Q
H
L
T
R
S
L
A
I
-----------------------
238
Blastp_CBE
48.04
31%
-47
- C1 -
-
2J0I
4
A:
[33-284]
-----------------------------------------------------------------------------------------------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
---
D
L
R
K
Q
Q
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
----------
F
L
-
E
G
-
G
-------------
A
---
L
T
D
---
I
V
T
HTRMN
E
E
Q
I
A
A
V
C
L
A
V
L
-----
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
-
S
K
E
-
V
P
R
R
K
L
--
V
--
G
T
P
Y
W
-
M
A
P
E
L
I
------
S
R
-
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
---
P
P
Y
---------------
F
N
------------------
E
P
P
L
K
--
A
M
K
M
I
R
D
----
N
L
P
P
R
L
K
N
L
H
-------
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
---------------------------------
236
Blastp_CBE
47.77
31%
-44
- C1 -
-
4APP
2
A:
[26-277]
-----------------------------------------------------------------------------------------------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
---
D
L
R
K
Q
Q
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
----------
F
L
-
E
G
-
G
-------------
A
---
L
T
D
---
I
V
T
HTRMN
E
E
Q
I
A
A
V
C
L
A
V
L
-----
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
-
S
K
E
-
V
P
R
R
K
L
--
V
--
G
T
P
Y
W
-
M
A
P
E
L
I
------
S
R
-
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
---
P
P
Y
---------------
F
N
------------------
E
P
P
L
K
--
A
M
K
M
I
R
D
----
N
L
P
P
R
L
K
N
L
H
-------
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
---------------------------------
217
Blastp_CBE
47.25
33%
-22
- C1 -
-
6B16
1
PAK1_HUMAN
A:
[28-274]
----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
--------
Q
Q
P
K
K
-
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
--
D
E
L
W
V
V
M
E
----------
Y
L
-
A
G
-
G
-------------
S
---
L
T
D
---
V
V
T
-----
E
T
C
M
D
E
G
Q
I
A
A
V
CRECL
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
-
T
P
E
-
Q
S
K
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
---
P
P
Y
L
-------------
N
E
N
------------------
P
-
L
R
A
--
L
Y
L
I
A
T
N
----
G
-
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
---------------------------------
225
Blastp_CBE
47.22
31%
-45
- C1 -
-
5XVG
8
A:
[23-274]
-----------------------------------------------------------------------------------------------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
---
D
L
R
K
Q
Q
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
----------
F
L
-
E
G
-
G
-------------
A
---
L
T
D
---
I
V
T
HTRMN
E
E
Q
I
A
A
V
C
L
A
V
L
-----
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
-
S
K
E
-
V
P
R
R
K
L
--
V
--
G
T
P
Y
W
-
M
A
P
E
L
I
------
S
R
-
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
---
P
P
Y
---------------
F
N
------------------
E
P
P
L
K
--
A
M
K
M
I
R
D
----
N
L
P
P
R
L
K
N
L
H
-------
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
---------------------------------
187
Blastp_CBE
47.01
32%
-24
- C1 -
-
5DFP
2
PAK1_HUMAN
A:
[27-273]
----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
Q
M
---
N
L
Q
Q
Q
P
K
K
-
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
G
-
G
-------------
S
---
L
T
D
---
V
V
T
-----
E
T
C
M
D
E
G
Q
I
A
A
V
CRECL
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
C
A
Q
I
-
T
P
E
-
Q
S
K
R
S
M
--
V
--
G
T
P
Y
W
-
M
A
P
E
V
V
------
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
---
P
P
Y
L
-------------
N
E
N
------------------
P
-
L
R
A
--
L
Y
L
I
A
T
N
----
G
-
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
---------------------------------
227
Blastp_CBE
46.66
31%
-40
- C1 -
-
2Q0N
7
A:
[31-282]
-----------------------------------------------------------------------------------------------------
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
---
D
L
R
K
Q
Q
R
R
-
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
----------
F
L
-
E
G
-
G
-------------
A
---
L
T
D
---
I
V
T
HTRMN
E
E
Q
I
A
A
V
C
L
A
V
L
-----
Q
A
L
S
V
L
H
A
Q
-
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
---
H
D
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
-
S
K
E
-
V
P
R
R
K
L
--
V
--
G
T
P
Y
W
-
M
A
P
E
L
I
------
S
R
-
L
P
-
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
---
P
P
Y
---------------
F
N
------------------
E
P
P
L
K
--
A
M
K
M
I
R
D
----
N
L
P
P
R
L
K
N
L
H
-------
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
L
---------------------------------
196
Blastp_CBE
44.44
33%
-22
- C1 -
-
4ZJI
1
?
D:
[29-275]
----------------------------------------------------------------------------------------------------------
K
I
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
Q
M
---
N
-----
K
K
-
E
L
I
I
N
E
I
L
V
M
R
E
N
K
N
P
N
I
V
N
Y
L
D
S
Y
L
V
G
D
E
L
W
V
V
M
E
----------
Y
L
-
A
G
-
G
-------------
S
---
L
T
D
---
V
V
T
-----
E
T
C
M
D
E
G
Q
I
A
A
V
CRECL
Q
A
L
E
F
L
H
S
N
-
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
---
M
D
G
S
V
K
L
T
D
F
G
F
-
A
Q
I
-
T
----
S
K
R
S
T
--
M
--
V
G
T
P
Y
W
M
A
P
E
V
V
------
T
R
-
K
A
-
Y
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
---
P
P
Y
L
-------------
N
E
N
------------------
P
-
L
R
A
--
L
Y
L
I
A
T
N
----
G
-
T
P
E
L
Q
N
P
E
-------
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
L
---------------------------------
310
Blastp_CBE
42.95
32%
-7
- C1 -
-
3HZT
9
?
A:
[11-298]
----------------------------------------------------------------------------------------------------------
K
L
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
K
S
S
V
T
T
T
S
N
S
-
G
A
L
L
D
E
V
A
V
L
K
Q
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
----------
V
Y
-
R
G
-
G
EL
F
D
E
I
I
L
R
Q
K
F
S
E
---
V
D
A
---
A
V
--------
I
M
K
Q
V
L
S
G
T
T
-----
Y
L
H
K
H
-----
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
SKS
R
D
A
L
I
K
I
V
D
F
G
L
S
A
H
F
E
V
--------------
G
T
A
Y
Y
-
I
A
P
E
V
L
-------
R
-
K
K
-
Y
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
------
Y
P
-------------
P
F
G
------------------
G
Q
T
D
Q
EI
L
K
R
V
E
K
G
KFSF
D
-
P
P
D
W
T
----------
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
N
H
P
W
I
V
K
F
------------------------------