@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : MUSK_HUMAN: (2020-09-17 )
MRELVNIPLVHILTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKVVKLEVEVFARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKDNKGYCAQYRGEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQECSPGVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSMHWDPTACARLPHLDYNKENLKTFPPMTSSKPSVDIPNLPSSSSSSFSVSPTYSMTVIISIMSSFAIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERAEGTVSV
Atome Classification :
(479 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540--........550.......560.......570......--.580-----........590.......---.--.600--.---------..-....610.......620-.......630.-.-.-.-...640.......650.......660.......670.......680........690..----.--.--...700.......710.......720.......730.---......740.......750.......760--.......770.......780.......790......-.800.......810----.-....-----.--.---820.......830.......840.......850.......860.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MRELVN
I
P
L
V
H
I
L
T
L
V
AFSGTEKLPKAPVITT
P
L
E
T
V
D
A
L
V
E
E
V
A
T
F
M
C
A
V
ESYPQPEISWTR
N
K
I
L
I
K
L
FDT
R
Y
S
IREN
G
Q
L
L
T
I
L
S
VEDSDD
G
I
Y
C
C
TANNGVG
G
A
VESC
G
A
L
Q
V
K
MKPKITRPPI
N
V
K
I
I
E
G
L
K
A
VLPCTTMGNPKPS
V
S
W
IKGDSPLREN
S
R
I
A
V
L
ESG
S
L
R
I
H
N
VQKEDAG
Q
Y
R
C
V
AKNSL
G
T
A
Y
S
K
V
V
K
L
E
V
E
V
F
A
R
I
LRAPESHN
V
T
F
G
S
F
V
T
L
H
C
TATGIPV
P
T
I
T
W
IENGNAVSS
G
S
I
Q
E
S
V
K
D
R
V
I
D
S
R
L
Q
L
F
ITKPG
L
Y
T
C
I
ATNKHGEKFSTAK
A
A
A
T
I
S
I
AEWSKPQKDNK
G
Y
C
A
Q
Y
R
G
E
V
C
N
A
V
L
AK
D
A
L
V
F
L
NTSYA
D
P
E
E
A
Q
E
L
L
V
H
TAWNE
L
K
VVS
P
V
C
R
P
A
A
E
A
L
L
C
N
H
I
F
Q
ECSPGVVPT
P
I
P
I
C
R
E
Y
C
L
A
V
K
E
L
F
C
A
K
E
W
L
V
M
EEKTHRG
L
Y
R
SE
M
H
L
LSVP
E
C
S
KLPSMHW
D
P
T
A
C
ARLPHLDYNK
E
N
L
KTFPPMTSSKPSVDIPNLPSSSSS
S
F
S
VSPTY
S
M
T
V
I
I
S
I
M
S
S
F
A
I
F
V
L
L
T
I
T
T
L
Y
C
C
R
R
R
K
Q
W
KNKKRES
A
A
V
T
L
TTL
P
S
---
E
L
L
L
D
RLHPN
P
M
Y
Q
RMPLLLN
P
K
L
L
S
L
EYPRN
N
I
E
Y
V
--
R
D
I------GE
G
A
F
G
R
V
F
--QARAPGL---L--PYE
P
--
F
---------
T
M
-
V
A
V
K
M
L
K
E
E
ASA
D
M
Q
A
D
-
F
Q
R
E
A
A
L
M
AEF-D-N-P-
N
I
V
K
L
L
G
VCAVG
K
P
M
C
L
L
F
E
Y
M
AY
G
D
L
N
E
F
L
R
SMSPH
T
V
C
S
LSHS-D
L
S
M
R
A
QVSSPGP----P--
P
--
L
S
C
A
E
Q
L
C
I
A
R
Q
V
A
A
G
M
A
Y
L
S
E
R
K
F
V
H
R
D
LATRNCLV---GE
N
M
V
V
K
I
ADFGLSRNIYSA
D
Y
Y
KANEND--
A
I
P
I
R
WMPP
E
S
I
F
Y
NRYTTES
D
V
W
A
Y
G
V
V
L
W
E
I
F
S
Y-GLQPYYGMAH
E
E
V
I
----
Y
-
Y
V
RD-----G--
N
---
I
LSCPENC
P
V
E
L
Y
N
L
M
R
L
C
W
S
KLPADRP
S
F
T
S
I
H
R
I
L
E
R
M
C
E
RAEGTVSV
563
HHSearch
98.03
97%
-155
- C6 -
-
1LUF
-
MUSK_RAT
A:
[563-860]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
L
S
L
E
Y
P
R
N
N
I
E
Y
V
--
R
D
I
------
G
E
G
A
F
G
R
V
F
--
Q
A
R
A
P
G
L
---
L
--
P
Y
E
P
--
F
---------
T
M
-
V
A
V
K
M
L
K
E
E
A
S
A
D
M
Q
A
D
-
F
Q
R
E
A
A
L
M
A
E
F
-
D
-
N
-
P
-
N
I
V
K
L
L
G
V
C
A
V
G
K
P
M
C
L
L
F
E
Y
M
A
Y
G
D
L
N
E
F
L
R
S
M
S
-----------------------
P
----
P
--
P
--
L
S
C
A
E
Q
L
C
I
A
R
Q
V
A
A
G
M
A
Y
L
S
E
R
K
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
M
V
V
K
I
A
D
F
G
L
S
R
N
I
Y
S
A
D
Y
Y
K
----
D
--
A
I
P
I
R
W
M
P
P
E
S
I
F
Y
N
R
Y
T
T
E
S
D
V
W
A
Y
G
V
V
L
W
E
I
F
S
Y
-
G
L
Q
P
Y
Y
G
M
A
H
E
E
V
I
----
Y
-
Y
V
R
D
-----
G
--
N
---
I
L
A
C
P
E
N
C
P
L
E
L
Y
N
L
M
R
L
C
W
S
K
L
P
A
D
R
P
S
F
C
S
I
H
R
I
L
Q
R
M
C
E
--------
1
PsiBlast_PDB
97.99
97%
-153
- C6 -
-
1LUF
-
MUSK_RAT
A:
[560-860]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
K
L
L
S
L
E
Y
P
R
N
N
I
E
Y
V
--
R
D
I
------
G
E
G
A
F
G
R
V
F
--
Q
A
R
A
P
G
L
---
L
--
P
Y
E
P
--
F
---------
T
M
-
V
A
V
K
M
L
K
E
E
A
S
A
D
M
Q
A
D
-
F
Q
R
E
A
A
L
M
A
E
F
-
D
-
N
-
P
-
N
I
V
K
L
L
G
V
C
A
V
G
K
P
M
C
L
L
F
E
Y
M
A
Y
G
D
L
N
E
F
L
R
S
M
S
-----------------------
P
----
P
--
P
--
L
S
C
A
E
Q
L
C
I
A
R
Q
V
A
A
G
M
A
Y
L
S
E
R
K
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
M
V
V
K
I
A
D
F
G
L
S
R
N
I
Y
S
A
D
Y
Y
K
----
D
--
A
I
P
I
R
W
M
P
P
E
S
I
F
Y
N
R
Y
T
T
E
S
D
V
W
A
Y
G
V
V
L
W
E
I
F
S
Y
-
G
L
Q
P
Y
Y
G
M
A
H
E
E
V
I
----
Y
-
Y
V
R
D
-----
G
--
N
---
I
L
A
C
P
E
N
C
P
L
E
L
Y
N
L
M
R
L
C
W
S
K
L
P
A
D
R
P
S
F
C
S
I
H
R
I
L
Q
R
M
C
E
--------
31
Blastp_CBE
81.66
49%
-154
- C6 -
-
6D20
2
A:
[31-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
---------------
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
--
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
32
Blastp_CBE
80.79
49%
-149
- C6 -
-
6D1Z
3
A:
[31-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
----------------
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
----
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
39
Blastp_CBE
80.66
49%
-145
- C6 -
-
5KMM
1
A:
[34-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
--
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
14
PsiBlast_PDB
80.64
49%
-139
- C6 -
-
4PMM
2
A:
[7-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
-----
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
----
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
41
Blastp_CBE
80.57
49%
-150
- C6 -
-
5KMK
1
A:
[34-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
--
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
43
Blastp_CBE
80.53
49%
-144
- C6 -
-
6NSS
1
A:
[23-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
20
PsiBlast_PDB
80.50
49%
-146
- C6 -
-
5KMJ
1
A:
[34-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
---
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
----
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
29
Blastp_CBE
80.39
49%
-156
- C6 -
-
6DKG
2
A:
[31-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
----------------
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
-----
Y
S
T
D
Y
Y
----
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
28
Blastp_CBE
79.75
49%
-151
- C6 -
-
6DKI
2
A:
[31-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
----------------
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
--
R
D
I
Y
S
T
D
Y
Y
----
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
16
PsiBlast_PDB
79.62
49%
-145
- C6 -
-
4PMS
1
A:
[7-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
-----
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
----
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
--
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
37
Blastp_CBE
79.48
49%
-150
- C6 -
-
5KMO
1
A:
[34-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
--
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
--
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
19
PsiBlast_PDB
79.46
49%
-145
- C6 -
-
5KMI
1
A:
[34-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
---
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
38
Blastp_CBE
79.44
49%
-144
- C6 -
-
5KMN
1
A:
[35-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
--
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
--
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
-----
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
18
PsiBlast_PDB
79.44
49%
-165
- C6 -
-
4AOJ
1
NTRK1_HUMAN
A:
[40-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
-----
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
-----------
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
----------------
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
15
PsiBlast_PDB
79.44
49%
-145
- C6 -
-
4PMP
1
A:
[7-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--------
K
---------
M
L
-
V
A
V
K
A
L
K
-----
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
I
Y
S
T
D
Y
Y
R
V
G
--
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
33
Blastp_CBE
79.30
49%
-146
- C6 -
-
6D1Y
1
A:
[31-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
-----
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
-------------
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
----
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
42
Blastp_CBE
79.26
49%
-146
- C6 -
-
6PL3
1
A:
[23-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
--
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
----
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
30
Blastp_CBE
79.08
49%
-161
- C6 -
-
6DKB
1
A:
[31-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
-----------------------
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
------
S
T
D
Y
Y
R
-------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
40
Blastp_CBE
79.07
49%
-143
- C6 -
-
5KML
1
A:
[35-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
--
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
--
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
-----
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
35
Blastp_CBE
79.02
49%
-161
- C6 -
-
4AOJ
1
C:
[40-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
-
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
----------------
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
------------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
27
Blastp_CBE
78.97
49%
-144
- C6 -
-
6NSP
1
A:
[8-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
---
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
25
Blastp_CBE
78.78
49%
-142
- C6 -
-
4YPS
1
A:
[14-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
---
G
K
V
F
--
L
A
E
C
H
N
L
---
L
-----
D
--
K
---------
M
L
-
V
A
V
K
A
L
----
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
--
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
24
Blastp_CBE
78.78
49%
-149
- C6 -
-
6J5L
1
A:
[14-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---------
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
----
I
Y
S
T
D
Y
Y
R
V
---
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
34
Blastp_CBE
78.63
49%
-143
- C6 -
-
5H3Q
3
A:
[35-314]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
-------------
K
---------
M
L
-
V
A
V
K
A
L
K
E
-----
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
26
Blastp_CBE
78.17
49%
-145
- C6 -
-
4YNE
2
A:
[14-293]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
--
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
------
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
-----
S
T
D
Y
Y
----
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
44
Blastp_CBE
77.51
50%
-139
- C6 -
-
5KVT
2
A:
[7-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---------
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----------------
36
Blastp_CBE
77.51
49%
-162
- C6 -
-
4AOJ
1
NTRK1_HUMAN
B:
[40-319]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
-----
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
----------------
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
---------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
84
Blastp_CBE
77.33
43%
-130
- C6 -
-
3NW6
1
A:
[14-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
---------------
N
N
P
V
L
----
A
--
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
17
PsiBlast_PDB
77.27
49%
-148
- C6 -
-
4PMT
1
A:
[7-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---------
D
--
K
---------
M
L
-
V
A
V
K
A
L
----------
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
--
S
R
D
I
Y
S
T
D
Y
Y
R
V
---
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
50
Blastp_CBE
77.06
46%
-159
- C6 -
-
3V5Q
1
B:
[14-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
R
E
L
------
G
---
F
-
K
V
F
--
L
A
E
C
Y
N
L
---
S
--
P
T
K
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
D
P
T
L
A
-
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
-
E
-
H
I
V
K
F
Y
G
V
C
--
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
----------------
E
----------------
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
R
----
T
--
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
----
E
-
C
I
T
Q
-----
G
--
R
---
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
----------
81
Blastp_CBE
76.70
42%
-124
- C6 -
-
5HHW
2
?
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
61
Blastp_CBE
76.69
42%
-123
- C6 -
-
3ETA
1
INSR_HUMAN
A:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
-
G
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
509
Blastp_CBE
76.44
39%
-138
- C6 -
-
2F4J
1
ABL1_HUMAN
A:
[2-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
102
Blastp_CBE
76.39
43%
-129
- C6 -
-
5FXS
1
A:
[15-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
---------------
M
E
N
N
P
V
L
----
A
--
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
A
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
E
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
482
Blastp_CBE
76.28
39%
-148
- C6 -
-
2HYY
1
ABL1_HUMAN
D:
[6-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
--
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
83
Blastp_CBE
76.28
43%
-128
- C6 -
-
3NW7
1
A:
[14-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
E
---------------
N
N
P
V
L
----
A
--
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
435
Blastp_CBE
76.24
39%
-141
- C6 -
-
2QOH
1
ABL1_MOUSE
B:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
---
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
434
Blastp_CBE
75.97
39%
-138
- C6 -
-
3KF4
1
ABL1_MOUSE
A:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
-------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
75
Blastp_CBE
76.00
42%
-125
- C6 -
-
4IBM
1
?
B:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
---
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
76
Blastp_CBE
75.99
42%
-123
- C6 -
-
4IBM
1
?
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
178
Blastp_CBE
75.98
40%
-137
- C6 -
-
2IVS
3
B:
[9-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
---------------------------
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
-----------
G
--
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
60
Blastp_CBE
75.97
42%
-122
- C6 -
-
3ETA
1
B:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
51
Blastp_CBE
75.95
46%
-163
- C6 -
-
3V5Q
1
NTRK3_HUMAN
A:
[14-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
R
E
L
------------
K
V
F
--
L
A
E
C
Y
N
L
---
S
--
P
T
K
D
--
K
---------
M
L
-
V
A
V
K
A
L
--
P
T
L
A
-
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
-
E
-
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
----------------
E
----------------
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
L
L
V
K
I
G
D
F
G
M
--
D
V
Y
S
T
D
Y
Y
R
----
T
--
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
----
E
-
C
I
T
Q
-----
G
--
R
---
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
----------
515
Blastp_CBE
75.90
39%
-144
- C6 -
-
2G2H
1
ABL1_HUMAN
B:
[8-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
520
Blastp_CBE
75.73
39%
-148
- C6 -
-
6NPV
2
ABL1_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
-------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
466
Blastp_CBE
75.79
39%
-143
- C6 -
-
2G1T
1
ABL1_HUMAN
D:
[3-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
89
Blastp_CBE
75.73
42%
-129
- C6 -
-
3EKN
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
498
Blastp_CBE
75.67
39%
-138
- C6 -
-
3CS9
1
ABL1_HUMAN
D:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
------------------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
464
Blastp_CBE
75.49
39%
-148
- C6 -
-
3UE4
1
ABL1_HUMAN
B:
[8-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
--
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
73
Blastp_CBE
75.45
43%
-130
- C6 -
-
3LW0
3
IGF1R_HUMAN
B:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
417
Blastp_CBE
75.42
39%
-137
- C6 -
-
3OY3
1
ABL1_MOUSE
A:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
74
Blastp_CBE
75.35
43%
-132
- C6 -
-
3LW0
2
IGF1R_HUMAN
A:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
433
Blastp_CBE
75.29
39%
-144
- C6 -
-
3KF4
1
ABL1_MOUSE
B:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
---
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
176
Blastp_CBE
75.28
40%
-130
- C6 -
-
6NEC
1
C:
[12-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
---------------------
E
----
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
---------
S
Q
G
--
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
524
Blastp_CBE
75.26
39%
-148
- C6 -
-
6NPE
2
ABL1_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
-------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
502
Blastp_CBE
75.20
39%
-153
- C6 -
-
2HZI
1
ABL1_HUMAN
B:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
----
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
522
Blastp_CBE
75.19
39%
-150
- C6 -
-
6NPU
2
ABL1_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
-------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
468
Blastp_CBE
75.15
39%
-143
- C6 -
-
2G1T
1
ABL1_HUMAN
B:
[5-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
45
Blastp_CBE
75.13
50%
-147
- C6 -
-
5I8A
1
A:
[10-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
---
G
K
V
F
--
L
A
E
C
H
N
-------------
K
---------
M
L
-
V
A
V
K
A
L
K
---------
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
-
S
R
D
I
-
S
T
D
Y
Y
R
V
---
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
----------------
431
Blastp_CBE
75.08
39%
-132
- C6 -
-
3KFA
1
ABL1_MOUSE
B:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
430
Blastp_CBE
75.04
39%
-137
- C6 -
-
2HIW
1
ABL1_HUMAN
A:
[3-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------
72
Blastp_CBE
74.99
43%
-131
- C6 -
-
3LW0
3
IGF1R_HUMAN
C:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
416
Blastp_CBE
74.96
39%
-136
- C6 -
-
3OY3
1
ABL1_MOUSE
B:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
55
Blastp_CBE
74.93
45%
-97
- C6 -
-
6KZC
1
?
A:
[8-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
R
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
Y
N
L
---
S
--
P
T
K
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
D
P
T
L
A
-
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
-
E
-
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
-------------
G
E
----------------
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
L
L
V
K
I
G
D
F
G
M
S
R
-
V
Y
S
T
D
Y
Y
R
L
----HT
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
----
E
-
C
I
T
Q
-----
G
--
R
---
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
----------
94
Blastp_CBE
74.85
43%
-134
- C6 -
-
3I81
1
A:
[14-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-
E
---------------
N
N
P
V
L
----
A
--
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
-------
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
480
Blastp_CBE
74.83
39%
-152
- C6 -
-
2HZ4
1
ABL1_HUMAN
B:
[6-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
-----------
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
432
Blastp_CBE
74.79
39%
-134
- C6 -
-
3KFA
1
ABL1_MOUSE
A:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
71
Blastp_CBE
74.78
43%
-131
- C6 -
-
3LW0
2
D:
[11-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
526
Blastp_CBE
74.76
39%
-147
- C6 -
-
3PYY
1
ABL1_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
----
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
576
HHSearch
74.67
41%
-133
- C6 -
-
6FEK
3
A:
[18-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
G
----------------
P
G
P
D
E
----
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
F
Y
V
K
R
S
Q
G
--
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
--------
179
Blastp_CBE
74.63
40%
-129
- C6 -
-
2IVS
5
RET_HUMAN
A:
[14-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
G
P
G
Y
L
---------------------
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
--
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
77
Blastp_CBE
74.59
43%
-128
- C6 -
-
3QQU
1
D:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
--------------------
L
----
A
--
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
506
Blastp_CBE
74.50
39%
-140
- C6 -
-
3QRI
1
ABL1_HUMAN
A:
[7-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
429
Blastp_CBE
74.48
39%
-132
- C6 -
-
2HIW
1
ABL1_HUMAN
B:
[3-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------
475
Blastp_CBE
74.47
41%
-144
- C6 -
-
2XYN
2
ABL2_HUMAN
A:
[28-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
------
V
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
--
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
D
-
L
L
E
K
-----
G
--
Y
---
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
----------
436
Blastp_CBE
74.41
39%
-138
- C6 -
-
2QOH
1
ABL1_MOUSE
A:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
---
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
503
Blastp_CBE
74.36
39%
-139
- C6 -
-
2HZI
1
ABL1_HUMAN
A:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
462
Blastp_CBE
74.21
39%
-152
- C6 -
-
4YC8
3
ABL1_HUMAN
B:
[8-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------------
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
489
Blastp_CBE
74.18
39%
-143
- C6 -
-
4WA9
1
ABL1_HUMAN
B:
[7-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
487
Blastp_CBE
74.16
39%
-147
- C6 -
-
4TWP
1
ABL1_HUMAN
A:
[4-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
-----
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
82
Blastp_CBE
74.06
42%
-146
- C6 -
-
5E1S
1
A:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
-------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
501
Blastp_CBE
73.98
39%
-143
- C6 -
-
3CS9
1
ABL1_HUMAN
A:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
----
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
477
Blastp_CBE
73.96
39%
-151
- C6 -
-
3QRJ
1
ABL1_HUMAN
A:
[12-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
-----
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
----------
484
Blastp_CBE
73.95
39%
-141
- C6 -
-
2HYY
1
ABL1_HUMAN
B:
[6-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
-
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
54
Blastp_CBE
73.94
45%
-96
- C6 -
-
6KZD
1
?
A:
[8-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
R
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
Y
N
L
---
S
--
P
T
K
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
D
P
T
L
A
-
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
-
E
-
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
-------------
G
E
----------------
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
L
----HT
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
----
E
-
C
I
T
Q
-----
G
--
R
---
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
----------
516
Blastp_CBE
73.93
39%
-136
- C6 -
-
2G2H
1
ABL1_HUMAN
A:
[8-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
467
Blastp_CBE
73.89
39%
-144
- C6 -
-
2G1T
1
ABL1_HUMAN
C:
[7-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
504
Blastp_CBE
73.88
39%
-143
- C6 -
-
3QRK
1
ABL1_HUMAN
A:
[7-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
----------
518
Blastp_CBE
73.79
39%
-137
- C6 -
-
2G2F
1
ABL1_HUMAN
A:
[7-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
90
Blastp_CBE
73.85
42%
-146
- C6 -
-
3EKK
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
--------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
473
Blastp_CBE
73.79
41%
-143
- C6 -
-
2XYN
4
ABL2_HUMAN
C:
[28-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
------
V
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
--
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
D
-
L
L
E
K
-----
G
--
Y
---
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
----------
492
Blastp_CBE
73.74
39%
-141
- C6 -
-
4ZOG
5
ABL1_HUMAN
A:
[5-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
471
Blastp_CBE
73.71
41%
-141
- C6 -
-
3HMI
1
ABL2_HUMAN
A:
[28-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
------
V
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
D
-
L
L
E
K
-----
G
--
Y
---
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
----------
486
Blastp_CBE
73.69
39%
-145
- C6 -
-
4TWP
1
ABL1_HUMAN
B:
[4-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
97
Blastp_CBE
73.51
42%
-134
- C6 -
-
1I44
1
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
505
Blastp_CBE
73.43
39%
-145
- C6 -
-
3QRI
1
ABL1_HUMAN
B:
[10-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
-----
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
390
Blastp_CBE
73.43
41%
-148
- C6 -
-
4XLI
1
ABL2_MOUSE
A:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
V
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
----
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
E
E
V
T
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
D
-
L
L
E
K
-----
G
--
Y
---
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
----------
78
Blastp_CBE
73.41
43%
-125
- C6 -
-
3QQU
1
IGF1R_HUMAN
C:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
-------------------
V
L
----
A
--
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
469
Blastp_CBE
73.33
39%
-145
- C6 -
-
2G1T
1
ABL1_HUMAN
A:
[7-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
80
Blastp_CBE
73.33
43%
-135
- C6 -
-
3QQU
1
IGF1R_HUMAN
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
474
Blastp_CBE
73.25
41%
-143
- C6 -
-
2XYN
4
ABL2_HUMAN
B:
[28-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
------
V
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
--
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
D
-
L
L
E
K
-----
G
--
Y
---
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
----------
572
HHSearch
73.30
39%
-132
- C6 -
-
3CBL
3
A:
[110-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
--
E
Q
I
------
G
R
G
N
F
G
E
V
F
--
S
G
R
L
R
A
----------
D
--
N
---------
T
L
-
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
-
P
-
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
----------------------------
A
--
R
--
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
--
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
-
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
----
E
-
F
V
E
K
-----
G
--
G
---
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
-------
438
Blastp_CBE
73.25
39%
-145
- C6 -
-
3OXZ
1
ABL1_MOUSE
A:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
--------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-----------
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
483
Blastp_CBE
73.20
39%
-145
- C6 -
-
2HYY
1
ABL1_HUMAN
C:
[6-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
-
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
---
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
527
Blastp_CBE
73.17
39%
-146
- C6 -
-
3DK3
1
ABL1_MOUSE
B:
[7-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
----
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
F
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
465
Blastp_CBE
73.15
39%
-138
- C6 -
-
3UE4
1
ABL1_HUMAN
A:
[8-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
514
Blastp_CBE
73.08
39%
-139
- C6 -
-
2G2I
1
ABL1_HUMAN
A:
[4-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
---
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
177
Blastp_CBE
73.07
40%
-123
- C6 -
-
6NEC
3
RET_HUMAN
A:
[14-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
G
P
G
Y
L
G
--------------
D
E
----
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
--
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
574
HHSearch
73.02
40%
-131
- C6 -
-
4CKJ
16
A:
[18-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
--------------------------
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
--
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
-------
121
Blastp_CBE
72.89
44%
-50
- C6 -
-
4QRC
1
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
G
P
-
D
L
S
P
D
G
P
R
S
S
E
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
86
Blastp_CBE
72.89
43%
-128
- C6 -
-
2OJ9
1
A:
[14-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
-----------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
476
Blastp_CBE
72.87
39%
-138
- C6 -
-
3QRJ
1
ABL1_HUMAN
B:
[11-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
---------
567
HHSearch
72.81
39%
-129
- C6 -
-
3BKB
7
A:
[110-375]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
--
E
Q
I
------
G
R
G
N
F
G
E
V
F
--
S
G
R
L
R
A
----------
D
--
N
---------
T
L
-
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
-
P
-
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
----------------------------
A
--
R
--
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
--
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
-
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
----
E
-
F
V
E
K
-----
G
--
G
---
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
-------
559
HHSearch
72.69
41%
-127
- C6 -
-
6BRJ
1
DDR1_HUMAN
A:
[568-874]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
--
L
C
E
V
-------------------------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
-------------------------
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
----
E
-
N
A
G
E
FFRDQ
G
RQ
V
---
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
-------
513
Blastp_CBE
72.69
39%
-139
- C6 -
-
2G2I
1
ABL1_HUMAN
B:
[7-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
----
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
93
Blastp_CBE
72.67
43%
-126
- C6 -
-
1JQH
1
IGF1R_HUMAN
A:
[15-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
--------------------
V
L
----
A
--
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
493
Blastp_CBE
72.66
39%
-140
- C6 -
-
2E2B
1
ABL1_HUMAN
B:
[7-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
-----
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
---------
494
Blastp_CBE
72.62
39%
-137
- C6 -
-
2E2B
1
ABL1_HUMAN
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
----
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
----
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
508
Blastp_CBE
72.54
39%
-132
- C6 -
-
2HZ0
1
ABL1_HUMAN
A:
[6-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
----------
472
Blastp_CBE
72.51
41%
-137
- C6 -
-
3GVU
2
ABL2_HUMAN
A:
[28-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
------
V
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
N
R
E
E
V
T
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
G
D
T
Y
T
----
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
D
-
L
L
E
K
-----
G
--
Y
---
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
----------
558
HHSearch
72.49
40%
-135
- C6 -
-
5FM3
1
A:
[59-353]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
--------------------------------
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
--
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
K
-------
7
PsiBlast_PDB
72.40
48%
-62
- C6 -
-
4AT5
2
A:
[12-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
N
I
V
L
K
--
R
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
Y
N
L
------------
K
---------
I
L
-
V
A
V
K
T
L
K
D
-
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
-
E
-
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
--------------
L
M
A
E
G
N
----
P
--
P
TE
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
--
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
----
E
-
C
I
T
Q
-----
G
--
R
---
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
--------
528
Blastp_CBE
72.36
39%
-144
- C6 -
-
3DK3
1
ABL1_MOUSE
A:
[7-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
----
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
F
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
491
Blastp_CBE
72.31
39%
-146
- C6 -
-
4ZOG
2
ABL1_HUMAN
B:
[6-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
--
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
91
Blastp_CBE
72.18
43%
-126
- C6 -
-
1JQH
1
C:
[15-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
--------------------
V
L
----
A
--
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
517
Blastp_CBE
72.14
39%
-138
- C6 -
-
2G2F
1
ABL1_HUMAN
B:
[9-275]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
-----------
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
P
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
566
HHSearch
72.13
39%
-132
- C6 -
-
6JMF
1
A:
[108-373]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
N
H
E
D
L
V
L
G
--
E
Q
I
------
G
R
G
N
F
G
E
V
F
--
S
G
R
L
R
A
----------
D
--
N
---------
T
L
-
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
-
P
-
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
----------------------------
A
--
R
--
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
--
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
-
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
----
E
-
F
V
E
K
-----
G
--
G
---
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
-------
463
Blastp_CBE
72.12
39%
-153
- C6 -
-
4YC8
3
ABL1_HUMAN
A:
[8-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------------
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
----
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
389
Blastp_CBE
72.05
41%
-144
- C6 -
-
4XLI
1
B:
[4-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
----
G
E
V
Y
--
V
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
L
E
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
S
R
E
E
V
T
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
D
-
L
L
E
K
-----
G
--
Y
---
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
T
H
Q
A
F
E
T
M
----------
560
HHSearch
72.02
41%
-116
- C6 -
-
6BSD
1
DDR1_HUMAN
A:
[567-874]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
--
L
C
E
V
D
S
-------------
P
---------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
L
E
D
K
A
------------------
G
----
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
--
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
----
E
-
N
A
G
E
FFRDQ
G
RQ
V
---
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
L
N
-------
511
Blastp_CBE
71.89
39%
-145
- C6 -
-
6BL8
1
ABL1_HUMAN
B:
[4-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
---
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
F
T
A
H
-
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
500
Blastp_CBE
71.87
39%
-159
* C6 *
-
3CS9
1
ABL1_HUMAN
B:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
---
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
525
Blastp_CBE
71.79
39%
-156
- C6 -
-
3PYY
3
ABL1_HUMAN
B:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
--------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
----------------
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
521
Blastp_CBE
71.67
39%
-159
- C6 -
-
6NPU
5
ABL1_HUMAN
B:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
--------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
----------------
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
46
Blastp_CBE
71.66
49%
-118
- C6 -
-
6PL2
1
A:
[23-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
T
-
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
6
PsiBlast_PDB
71.58
48%
-63
- C6 -
-
4AT4
1
A:
[12-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
N
I
V
L
K
--
R
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
Y
N
L
---
C
--------
K
---------
I
L
-
V
A
V
K
T
L
K
D
-
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
-
E
-
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
--------------
L
M
A
-------
P
--
P
TE
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
--
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
----
E
-
C
I
T
Q
-----
G
--
R
---
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
--------
497
Blastp_CBE
71.50
39%
-137
- C6 -
-
5HU9
14
ABL1_HUMAN
A:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
---------
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------
103
Blastp_CBE
71.50
43%
-132
- C6 -
-
3D94
1
A:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
----------------------------------
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
119
Blastp_CBE
71.38
44%
-51
- C6 -
-
6JPJ
1
A:
[19-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
G
P
-
D
L
S
P
D
G
P
R
S
S
E
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
519
Blastp_CBE
71.26
39%
-156
- C6 -
-
6NPV
5
ABL1_HUMAN
B:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
--------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
----------------
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
512
Blastp_CBE
71.26
39%
-139
- C6 -
-
6BL8
1
ABL1_HUMAN
A:
[4-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
F
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
79
Blastp_CBE
71.28
43%
-129
- C6 -
-
3QQU
1
IGF1R_HUMAN
B:
[8-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
----------------------------------
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
5
PsiBlast_PDB
71.26
48%
-64
- C6 -
-
4AT3
1
A:
[12-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
N
I
V
L
K
--
R
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
Y
N
L
---
C
--------
K
---------
I
L
-
V
A
V
K
T
L
---
A
S
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
-
E
-
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
D
A
V
--------------
L
M
A
--
N
----
P
--
P
TE
L
T
Q
S
Q
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
L
L
V
K
I
G
D
F
G
M
S
R
--
Y
S
T
D
Y
Y
R
V
G
G
H
T
--
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
N
E
V
I
----
E
-
C
I
T
Q
-----
G
--
R
---
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
N
L
A
K
--------
499
Blastp_CBE
71.18
39%
-158
- C6 -
-
3CS9
1
ABL1_HUMAN
C:
[9-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
-----
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
---------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
---------
161
Blastp_CBE
71.09
44%
-53
- C6 -
-
6IUP
2
?
A:
[30-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
--
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
----------------
P
R
S
S
E
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
523
Blastp_CBE
70.87
39%
-159
- C6 -
-
6NPE
3
ABL1_HUMAN
B:
[19-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
--------
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
92
Blastp_CBE
70.47
43%
-124
- C6 -
-
1JQH
1
IGF1R_HUMAN
B:
[15-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
------------------------------
P
--
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------
Y
Y
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
47
Blastp_CBE
70.23
49%
-113
- C6 -
-
6PL1
1
?
A:
[23-302]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
T
-
D
Y
Y
R
V
G
-----
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
529
Blastp_CBE
69.92
40%
-53
- C6 -
-
4HVS
1
A:
[42-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
Q
G
L
---
I
--
K
S
D
A
--
A
---------
M
T
-
V
A
V
K
M
L
K
P
S
A
H
S
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
-
G
-
N
H
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
----
S
F
H
S
S
-
D
T
S
P
A
S
M
E
D
D
E
N
A
----------
L
D
L
E
D
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
D
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
N
S
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
----
Y
K
M
I
K
E
-----
G
--
F
---
R
M
S
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
D
K
R
P
T
F
K
Q
I
V
Q
D
I
E
K
-----------
49
Blastp_CBE
69.78
49%
-114
- C6 -
-
6NPT
1
A:
[17-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-----
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------------
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
T
-
D
Y
Y
R
V
G
G
R
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
197
Blastp_CBE
69.40
43%
-52
- C6 -
-
4XCU
1
A:
[13-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
----------------
S
S
E
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
209
Blastp_CBE
69.35
40%
-106
- C6 -
-
2IVU
3
A:
[11-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
----------------------------
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
412
Blastp_CBE
69.14
40%
-71
- C6 -
-
4R7I
1
?
A:
[46-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
A
-
E
A
M
L
G
P
S
L
S
-------------
G
----
R
--
P
--
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
Q
E
Q
A
---------
48
Blastp_CBE
69.04
49%
-106
- C6 -
-
5WR7
1
A:
[19-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
W
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
D
I
Y
T
-
D
Y
Y
R
V
G
G
----
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
118
Blastp_CBE
68.98
44%
-52
- C6 -
-
4UXQ
1
A:
[17-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
--------------
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
510
Blastp_CBE
68.77
40%
-73
- C6 -
-
3LCD
1
?
A:
[42-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
A
---------------
E
A
D
L
D
-----------
P
--
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
--
S
N
Y
I
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
----------
366
Blastp_CBE
68.55
41%
-50
- C6 -
-
5VND
8
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
-----------
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
53
Blastp_CBE
68.44
46%
-128
- C6 -
-
4YMJ
4
NTRK3_HUMAN
A:
[14-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
R
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
Y
N
L
---
S
--
P
T
K
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
D
P
T
L
A
-
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
-
E
-
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---------------
G
E
----------------
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
L
L
V
K
I
G
D
F
G
---
D
V
Y
T
-
D
Y
Y
R
V
---
T
--
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
----
E
-
C
I
T
Q
-----
G
--
R
---
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
----------
550
Blastp_CBE
68.42
39%
-67
- C6 -
-
6HH1
1
?
A:
[19-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
Y
G
L
---
I
--
K
S
D
A
--
A
---------
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
-
G
-
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
T
S
P
-
A
I
E
L
A
L
D
L
E
D
------------------
L
L
S
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
----
Y
K
M
I
K
E
-----
G
--
F
---
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
-----------
570
HHSearch
68.36
41%
-43
- C6 -
-
3TT0
1
FGFR1_HUMAN
A:
[65-357]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
KD
K
P
N
R
--
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
E
Y
S
----
Y
-----
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
---
52
Blastp_CBE
68.35
46%
-125
- C6 -
-
4YMJ
4
B:
[14-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
--
R
E
L
------
G
E
G
A
F
G
K
V
F
--
L
A
E
C
Y
N
L
---
S
--
P
T
K
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
D
P
T
L
A
-
A
R
K
D
-
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
-
E
-
H
I
V
K
F
Y
G
V
C
G
D
G
-
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
H
G
P
---------------
G
E
----------------
L
G
L
S
Q
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
A
N
L
L
V
K
I
G
D
F
G
M
S
R
D
V
Y
T
-
D
Y
Y
R
V
---
T
--
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
Y
-
G
K
Q
P
W
F
Q
L
S
N
T
E
V
I
----
E
-
C
I
T
Q
-----
G
--
R
---
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
----------
507
Blastp_CBE
68.30
39%
-154
- C6 -
-
2HZ0
1
ABL1_HUMAN
B:
[1-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------------
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
----
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
--------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
----------
210
Blastp_CBE
68.20
40%
-103
- C6 -
-
2IVT
3
A:
[9-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
--------------------------
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
411
Blastp_CBE
68.15
40%
-62
- C6 -
-
6N33
1
A:
[46-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
A
-
E
A
M
L
G
P
S
L
S
-------------
G
----
R
--
P
--
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
Q
E
Q
A
Q
--------
208
Blastp_CBE
68.07
40%
-106
- C6 -
-
2X2K
4
A:
[9-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
--------------------------
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
229
Blastp_CBE
68.05
41%
-50
- C6 -
-
4ZSA
1
FGFR1_HUMAN
A:
[15-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
414
Blastp_CBE
67.97
40%
-71
- C6 -
-
4HW7
1
A:
[46-338]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
A
-
E
A
M
L
G
P
S
---------------
G
----
R
--
P
--
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
Q
E
Q
A
---------
488
Blastp_CBE
67.96
40%
-110
- C6 -
-
5AMN
7
A:
[10-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
---------------
S
R
K
V
------
E
----
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
537
Blastp_CBE
67.94
40%
-66
- C6 -
-
6IG8
2
?
A:
[27-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
A
-
E
A
M
L
G
P
S
L
--------------
G
----
R
--
P
--
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
--------
444
Blastp_CBE
67.88
39%
-61
- C6 -
-
6HD4
3
ABL1_MOUSE
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
----
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
413
Blastp_CBE
67.81
40%
-68
- C6 -
-
4R7H
1
A:
[46-339]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
R
R
K
A
-
E
A
M
L
G
P
S
L
--------------
G
----
R
--
P
--
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
Q
E
Q
A
Q
--------
250
Blastp_CBE
67.81
41%
-55
- C6 -
-
4V05
4
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
-----------
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
490
Blastp_CBE
67.78
39%
-142
- C6 -
-
4WA9
1
ABL1_HUMAN
A:
[10-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
-----------------------
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
---
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
238
Blastp_CBE
67.75
41%
-56
- C6 -
-
1FGI
1
FGFR1_HUMAN
A:
[17-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
442
Blastp_CBE
67.72
39%
-60
- C6 -
-
6HD6
2
ABL1_MOUSE
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
-----
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
544
Blastp_CBE
67.67
39%
-66
- C6 -
-
6MOB
1
KIT_HUMAN
A:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
Y
G
L
---
I
--
K
S
D
A
--
A
---------
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
-
G
-
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
T
S
P
-
A
I
M
E
D
D
E
L
A
L
D
L
E
----
D
--
L
--
L
S
------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
----
Y
K
M
I
K
E
-----
G
--
F
---
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
-----------
207
Blastp_CBE
67.62
40%
-105
- C6 -
-
2X2L
5
A:
[12-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
--
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
--------------------------
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
133
Blastp_CBE
67.59
44%
-70
- C6 -
-
5NWZ
1
FGFR4_HUMAN
A:
[15-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
G
P
-
D
L
----------
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
452
Blastp_CBE
67.54
39%
-63
- C6 -
-
3K5V
2
ABL1_MOUSE
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
----
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
335
Blastp_CBE
67.53
41%
-42
- C6 -
-
3TT0
1
FGFR1_HUMAN
A:
[65-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
298
Blastp_CBE
67.50
41%
-48
- C6 -
-
3JS2
1
B:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
552
Blastp_CBE
67.41
40%
-67
- C6 -
-
2I1M
1
A:
[42-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
-----
R
V
L
E
T
-
D
-------
S
T
A
-------------
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
--------
227
Blastp_CBE
67.35
41%
-53
- C6 -
-
5Z0S
1
FGFR1_HUMAN
A:
[15-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
249
Blastp_CBE
67.32
41%
-54
- C6 -
-
4V05
3
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
-----
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
----
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
221
Blastp_CBE
67.33
41%
-48
- C6 -
-
3RHX
5
FGFR1_HUMAN
A:
[13-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
233
Blastp_CBE
67.32
41%
-54
- C6 -
-
5AM6
1
FGFR1_HUMAN
A:
[17-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
-----------
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
225
Blastp_CBE
67.30
41%
-46
- C6 -
-
6ITJ
1
?
A:
[15-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
248
Blastp_CBE
67.27
41%
-51
- C6 -
-
5EW8
1
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
-----------
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
545
Blastp_CBE
67.23
39%
-62
- C6 -
-
1T46
1
?
A:
[19-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
Y
G
L
---
I
--
K
S
D
A
--
A
---------
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
-
G
-
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
---------------
L
A
L
D
L
E
----
D
--
L
--
L
S
------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
----
Y
K
M
I
K
E
-----
G
--
F
---
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
-----------
224
Blastp_CBE
67.22
41%
-47
- C6 -
-
6ITJ
1
?
B:
[15-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
-----
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
532
Blastp_CBE
67.16
40%
-79
- C6 -
-
3KRJ
1
A:
[42-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
P
--------
P
-
G
-------------------
Q
--
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
---------
367
Blastp_CBE
67.13
41%
-47
- C6 -
-
5VND
10
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
470
Blastp_CBE
67.11
39%
-102
- C6 -
-
6NE7
2
A:
[12-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
A
S
L
R
G
F
L
R
E
S
R
K
V
G
--------------------
E
----
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
242
Blastp_CBE
67.09
41%
-48
- C6 -
-
3C4F
1
FGFR1_HUMAN
A:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-------------
P
E
E
Q
L
S
S
K
D
L
----------
V
S
C
A
------
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
420
Blastp_CBE
66.95
38%
-58
- C6 -
-
2Z60
1
ABL1_MOUSE
A:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
G
-----------
V
W
K
K
--
Y
---------
S
L
T
V
A
V
K
T
L
K
E
---
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
299
Blastp_CBE
66.91
41%
-48
- C6 -
-
3JS2
1
FGFR1_HUMAN
A:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
-------
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
437
Blastp_CBE
66.88
39%
-99
- C6 -
-
4CKI
8
A:
[12-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
--------------------
D
E
----
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
T
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
244
Blastp_CBE
66.85
41%
-50
- C6 -
-
5O4A
2
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
-----------
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
553
Blastp_CBE
66.77
39%
-63
- C6 -
-
6ITV
1
?
A:
[37-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
Y
G
L
---
I
--
K
S
D
A
--
A
---------
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
-
G
-
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
------------
E
D
D
E
L
A
L
D
L
E
----
D
--
L
--
L
S
------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
----
Y
K
M
I
K
E
-----
G
--
F
---
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
-----------
551
Blastp_CBE
66.81
39%
-64
- C6 -
-
4U0I
1
A:
[21-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
Y
G
L
---
I
-----
A
--
A
---------
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
-
G
-
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
------------
L
A
L
D
L
E
----
D
--
L
--
L
S
------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
----
Y
K
M
I
K
E
-----
G
--
F
---
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
-----------
292
Blastp_CBE
66.77
41%
-45
- C6 -
-
4RWK
1
FGFR1_HUMAN
A:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
258
Blastp_CBE
66.76
41%
-49
- C6 -
-
4UWB
4
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
--
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
449
Blastp_CBE
66.70
39%
-57
- C6 -
-
3MS9
2
ABL1_MOUSE
B:
[7-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
---
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
290
Blastp_CBE
66.69
41%
-47
- C6 -
-
5ZV2
1
FGFR1_HUMAN
A:
[13-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------
E
Q
L
S
S
K
D
L
----------
V
S
C
A
------
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
--
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
418
Blastp_CBE
66.61
38%
-61
- C6 -
-
3IK3
1
ABL1_MOUSE
B:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
G
-----------
V
W
K
K
--
Y
---------
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
385
Blastp_CBE
66.65
40%
-67
- C6 -
-
3LCT
3
A:
[44-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
G
M
------
P
N
D
P
--
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
241
Blastp_CBE
66.63
41%
-52
- C6 -
-
3C4F
1
B:
[9-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
-------------
P
E
E
Q
L
S
S
K
D
L
----------
V
S
C
A
------
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
535
Blastp_CBE
66.62
40%
-73
- C6 -
-
2I0V
1
A:
[42-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
-------------------------------
Q
--
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
--------
226
Blastp_CBE
66.61
41%
-51
- C6 -
-
5Z0S
1
B:
[15-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
399
Blastp_CBE
66.57
40%
-49
- C6 -
-
5A46
4
FGFR1_HUMAN
A:
[36-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
G
L
-----------
E
E
Q
L
S
S
----------------
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
372
Blastp_CBE
66.57
40%
-70
- C6 -
-
4CNH
2
B:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
----------------
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
Y
-----
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
295
Blastp_CBE
66.58
41%
-48
- C6 -
-
4RWJ
1
FGFR1_HUMAN
A:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
-
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
228
Blastp_CBE
66.57
41%
-55
- C6 -
-
4ZSA
1
B:
[15-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
530
Blastp_CBE
66.55
40%
-66
- C6 -
-
6T2W
1
?
A:
[35-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
A
-
E
A
M
L
-----------------------
R
--
P
--
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
--------
455
Blastp_CBE
66.46
39%
-60
- C6 -
-
1OPJ
2
ABL1_MOUSE
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
546
Blastp_CBE
66.42
39%
-71
- C6 -
-
1PKG
1
B:
[35-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
Y
G
L
---
I
--
K
S
D
A
--
A
---------
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
-
G
-
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
---------------
L
D
L
E
----
D
--
L
--
L
S
------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
---------------
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
----
Y
K
M
I
K
E
-----
G
--
F
---
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
-----------
445
Blastp_CBE
66.48
39%
-61
- C6 -
-
3MSS
2
ABL1_MOUSE
D:
[4-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
223
Blastp_CBE
66.47
41%
-52
- C6 -
-
5AM7
1
FGFR1_HUMAN
A:
[17-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
----------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
383
Blastp_CBE
66.46
40%
-103
- C6 -
-
6NJA
2
A:
[12-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
---------------------
E
----
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
342
Blastp_CBE
66.42
40%
-71
- C6 -
-
5IUI
1
A:
[27-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
G
----------
P
--
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-----
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
362
Blastp_CBE
66.41
41%
-49
- C6 -
-
6P69
3
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
243
Blastp_CBE
66.34
41%
-53
- C6 -
-
5O4A
1
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
------
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-----
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
251
Blastp_CBE
66.29
41%
-53
- C6 -
-
4V04
6
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
204
Blastp_CBE
66.28
40%
-100
- C6 -
-
4CKJ
16
A:
[12-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
--------------------------
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
361
Blastp_CBE
66.21
41%
-48
- C6 -
-
6P69
2
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
358
Blastp_CBE
66.23
40%
-73
- C6 -
-
4Z55
3
A:
[39-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------------------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
-
K
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
231
Blastp_CBE
66.21
41%
-46
- C6 -
-
5B7V
1
FGFR1_HUMAN
A:
[17-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
----
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
263
Blastp_CBE
66.17
41%
-53
- C6 -
-
4NK9
2
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
---------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
195
Blastp_CBE
66.17
43%
-60
- C6 -
-
6NVH
1
A:
[13-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
----------------
S
S
E
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
132
Blastp_CBE
66.15
44%
-66
- C6 -
-
5NWZ
1
B:
[15-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
---------------
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
-----------------
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
246
Blastp_CBE
66.14
41%
-50
- C6 -
-
5O49
1
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
554
Blastp_CBE
66.13
39%
-69
- C6 -
-
6KLA
1
?
A:
[37-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
Y
G
L
---
I
--
K
S
D
A
--
A
---------
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
-
G
-
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
------------
E
D
D
E
L
A
L
D
L
E
----
D
--
L
--
L
S
------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
----
Y
K
M
I
K
E
-----
G
--
F
---
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
-----------
451
Blastp_CBE
66.12
39%
-62
- C6 -
-
3K5V
2
ABL1_MOUSE
B:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
457
Blastp_CBE
66.02
39%
-61
- C6 -
-
1M52
1
ABL1_MOUSE
A:
[10-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
308
Blastp_CBE
66.06
41%
-62
- C6 -
-
6NVL
1
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
---------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
--------
Y
Y
K
K
-
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
536
Blastp_CBE
65.96
40%
-75
- C6 -
-
3BEA
1
A:
[42-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
S
-----
R
V
L
-----------
S
T
-------------
L
S
T
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
--------
194
Blastp_CBE
66.02
43%
-60
- C6 -
-
6NVI
1
A:
[13-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
----
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
------------------
S
E
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
V
---------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
565
HHSearch
66.01
41%
-29
- C6 -
-
5A46
2
B:
[35-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
L
A
E
A
I
G
L
----D-
K
P
N
R
--
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------------
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
------
534
Blastp_CBE
65.96
40%
-73
- C6 -
-
2I0Y
1
?
A:
[42-328]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
-------------------------------
Q
--
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
--------
240
Blastp_CBE
65.93
41%
-55
- C6 -
-
1AGW
1
FGFR1_HUMAN
A:
[17-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
-----------
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
206
Blastp_CBE
65.93
40%
-111
- C6 -
-
2X2M
3
RET_HUMAN
A:
[11-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
--------
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
-----------------------------
R
--
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
402
Blastp_CBE
65.88
40%
-66
- C6 -
-
4MKC
3
A:
[67-340]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
--------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
453
Blastp_CBE
65.83
39%
-59
- C6 -
-
2HZN
1
ABL1_MOUSE
A:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
---
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
--
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
403
Blastp_CBE
65.85
40%
-66
- C6 -
-
3L9P
4
A:
[67-340]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
G
-------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
262
Blastp_CBE
65.83
41%
-56
- C6 -
-
4NKA
3
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
----
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
245
Blastp_CBE
65.80
41%
-52
- C6 -
-
5O49
1
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
-----
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
----------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-----
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
131
Blastp_CBE
65.78
44%
-63
- C6 -
-
4QQ5
1
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
R
A
E
A
F
G
M
----------DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
--------------
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
459
Blastp_CBE
65.74
39%
-60
- C6 -
-
1IEP
1
ABL1_MOUSE
A:
[7-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
398
Blastp_CBE
65.69
40%
-48
- C6 -
-
5A46
2
B:
[36-321]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
----------
H
N
P
E
E
Q
L
S
S
----------------
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
193
Blastp_CBE
65.67
43%
-64
- C6 -
-
6NVJ
1
A:
[13-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
--
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
----------------
S
S
E
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
458
Blastp_CBE
65.61
39%
-65
- C6 -
-
1IEP
1
ABL1_MOUSE
B:
[7-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
531
Blastp_CBE
65.64
40%
-78
- C6 -
-
3KRL
1
A:
[42-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
-
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
-------------------------------
Q
--
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
K
G
-
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
-----------
386
Blastp_CBE
65.63
40%
-62
- C6 -
-
3LCS
3
A:
[44-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
G
M
------
P
N
D
P
--
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
237
Blastp_CBE
65.61
41%
-59
- C6 -
-
1FGI
1
B:
[17-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
443
Blastp_CBE
65.56
39%
-64
- C6 -
-
6HD4
2
ABL1_MOUSE
B:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
268
Blastp_CBE
65.60
41%
-55
- C6 -
-
4F64
3
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
-----------
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
456
Blastp_CBE
65.53
39%
-60
- C6 -
-
1M52
3
ABL1_MOUSE
B:
[10-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
105
Blastp_CBE
65.58
41%
-86
- C6 -
-
1IR3
1
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
---
R
K
G
G
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
365
Blastp_CBE
65.53
41%
-47
- C6 -
-
6P68
1
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
556
Blastp_CBE
65.47
39%
-63
- C6 -
-
6ITT
2
?
A:
[37-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
Y
G
L
---
I
--
K
S
D
A
--
A
---------
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
-
G
-
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
------------
E
D
D
E
L
A
L
D
L
E
----
D
--
L
--
L
S
------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
----
Y
K
M
I
K
E
-----
G
--
F
---
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
-----------
222
Blastp_CBE
65.53
41%
-48
- C6 -
-
5AM7
1
B:
[17-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
----------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
236
Blastp_CBE
65.51
41%
-58
- C6 -
-
2FGI
1
FGFR1_HUMAN
A:
[17-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
-----------
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
---------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-
D
I
H
H
I
D
Y
Y
K
K
-
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
116
Blastp_CBE
65.51
41%
-83
- C6 -
-
1RQQ
1
INSR_HUMAN
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
---
R
K
G
G
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
255
Blastp_CBE
65.46
41%
-47
- C6 -
-
4UWC
9
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
---
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
253
Blastp_CBE
65.47
41%
-55
- C6 -
-
4V01
6
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
--
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
-----
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
232
Blastp_CBE
65.46
41%
-58
- C6 -
-
5AM6
1
B:
[17-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-------------
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
441
Blastp_CBE
65.45
39%
-61
- C6 -
-
6HD6
1
ABL1_MOUSE
B:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
------
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
293
Blastp_CBE
65.44
41%
-58
- C6 -
-
4RWL
1
B:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
-----
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
391
Blastp_CBE
65.43
40%
-74
- C6 -
-
4FOC
1
A:
[53-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
--------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
270
Blastp_CBE
65.42
41%
-55
- C6 -
-
4F63
3
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
-----------
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
256
Blastp_CBE
65.41
41%
-45
- C6 -
-
4UWC
9
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
-
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
461
Blastp_CBE
65.36
39%
-61
- C6 -
-
1FPU
1
ABL1_MOUSE
A:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------
123
Blastp_CBE
65.35
41%
-88
- C6 -
-
4XLV
1
?
A:
[35-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
---
R
K
G
G
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
555
Blastp_CBE
65.27
39%
-61
- C6 -
-
6ITT
2
?
B:
[37-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
Y
G
L
---
I
--
K
S
D
A
--
A
---------
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
-
G
-
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
-------------
M
E
D
D
E
L
A
L
D
L
E
----
D
--
L
--
L
S
------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
----
Y
K
M
I
K
E
-----
G
--
F
---
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
-----------
264
Blastp_CBE
65.34
41%
-52
- C6 -
-
4NK9
5
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
---
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
313
Blastp_CBE
65.28
40%
-67
- C6 -
-
5AAB
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
--
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
454
Blastp_CBE
65.29
39%
-58
- C6 -
-
1OPJ
2
ABL1_MOUSE
B:
[7-278]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
205
Blastp_CBE
65.28
40%
-113
- C6 -
-
2X2M
4
B:
[9-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
----
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
--------------------------------
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
291
Blastp_CBE
65.27
41%
-57
- C6 -
-
4RWK
1
B:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
--
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
106
Blastp_CBE
65.26
41%
-85
- C6 -
-
1GAG
1
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
---
R
K
G
G
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
447
Blastp_CBE
65.21
39%
-61
- C6 -
-
3MSS
2
ABL1_MOUSE
B:
[4-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
339
Blastp_CBE
65.21
40%
-72
- C6 -
-
4FOD
2
A:
[33-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
--------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
247
Blastp_CBE
65.20
41%
-49
- C6 -
-
5EW8
1
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
--
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
538
Blastp_CBE
65.19
40%
-66
- C6 -
-
3LCO
1
A:
[27-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
--
K
E
D
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
A
-
E
A
M
L
G
P
S
---------------
G
----
R
--
P
--
L
E
L
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
------
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
Q
A
Q
--------
314
Blastp_CBE
65.16
40%
-65
- C6 -
-
5AA8
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
---
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
257
Blastp_CBE
65.13
41%
-44
- C6 -
-
4UWB
3
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
---
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
220
Blastp_CBE
65.13
41%
-54
- C6 -
-
3RHX
2
B:
[13-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
115
Blastp_CBE
65.13
41%
-85
- C6 -
-
1RQQ
1
B:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
---
R
K
G
G
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
394
Blastp_CBE
65.07
40%
-65
- C6 -
-
5A9U
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
---
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
336
Blastp_CBE
65.07
41%
-71
- C6 -
-
4ANQ
1
A:
[41-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
--------
G
A
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
156
Blastp_CBE
65.07
44%
-55
- C6 -
-
4TYJ
2
A:
[19-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
--
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
----------------------
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
219
Blastp_CBE
65.03
41%
-51
- C6 -
-
5A4C
6
FGFR1_HUMAN
A:
[14-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
--
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
110
Blastp_CBE
64.98
41%
-90
- C6 -
-
3BU5
1
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
---
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
---
R
K
G
G
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
230
Blastp_CBE
64.95
41%
-51
- C6 -
-
5B7V
1
B:
[17-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
Y
K
K
T
T
-
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
322
Blastp_CBE
64.92
40%
-72
- C6 -
-
5FTQ
2
A:
[18-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
-
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
547
Blastp_CBE
64.83
39%
-62
- C6 -
-
1PKG
1
KIT_HUMAN
A:
[35-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
R
L
S
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
Y
G
L
---
I
--
K
S
D
A
--
A
---------
M
T
-
V
A
V
K
M
L
K
P
S
A
H
L
T
E
R
E
A
-
L
M
S
E
L
K
V
L
S
Y
L
-
G
-
N
-
H
M
N
I
V
N
L
L
G
A
C
T
I
G
G
P
T
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
K
R
D
S
F
I
C
S
K
------------
A
L
D
L
E
----
D
--
L
--
L
S
------
F
S
Y
Q
V
A
K
G
M
A
F
L
A
S
K
N
C
I
H
R
D
L
A
A
R
N
I
L
L
---
T
H
G
R
I
T
K
I
C
D
F
G
L
A
R
D
I
K
N
D
S
N
Y
V
V
K
G
N
A
--
R
L
P
V
K
W
M
A
P
E
S
I
F
N
C
V
Y
T
F
E
S
D
V
W
S
Y
G
I
F
L
W
E
L
F
S
L
-
G
S
S
P
Y
P
G
M
P
V
D
S
K
F
----
Y
K
M
I
K
E
-----
G
--
F
---
R
M
L
S
P
E
H
A
P
A
E
M
Y
D
I
M
K
T
C
W
D
A
D
P
L
K
R
P
T
F
K
Q
I
V
Q
L
I
E
K
-----------
218
Blastp_CBE
64.88
41%
-53
- C6 -
-
5A4C
7
B:
[14-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
-----
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
579
Fugue
64.87
31%
-31
- C6 -
-
3CD3
3
A:
[1-376]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
Y
H
G
A
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
E
Y
V
L
S
V
P
R
H
F
I
I
N
L
Y
R
L
F
P
SIP
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
K
D
K
W
V
L
N
H
E
D
L
V
L
G
--
E
Q
I
------
G
R
G
N
F
G
E
V
F
--
S
G
R
L
R
A
----------
D
--
N
---------
T
L
-
V
A
V
K
S
C
R
P
----
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
-
P
-
N
I
V
R
L
I
G
V
C
T
Q
K
Q
P
I
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
E
G
A
R
--------------------------------
L
R
V
K
T
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
---
T
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
-
A
D
G
V
A
A
S
G
G
L
R
--
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
-
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
----
E
-
F
V
E
K
-----
G
--
G
---
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
------
400
Blastp_CBE
64.83
41%
-63
- C6 -
-
1OEC
1
A:
[23-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
M
A
E
A
V
G
I
---
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
------------------
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
157
Blastp_CBE
64.86
44%
-57
- C6 -
-
4TYI
1
A:
[19-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
---------------
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
G
----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
134
Blastp_CBE
64.86
44%
-60
- C6 -
-
5NUD
1
B:
[15-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
---------------
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
--------------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
364
Blastp_CBE
64.85
41%
-51
- C6 -
-
6P68
1
FGFR1_HUMAN
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
381
Blastp_CBE
64.83
40%
-68
- C6 -
-
4CLJ
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
460
Blastp_CBE
64.82
39%
-60
- C6 -
-
1FPU
1
ABL1_MOUSE
B:
[7-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
------
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
-------
450
Blastp_CBE
64.80
39%
-61
- C6 -
-
3MS9
2
ABL1_MOUSE
A:
[5-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
--
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
266
Blastp_CBE
64.70
41%
-54
- C6 -
-
4F65
5
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
----------
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
252
Blastp_CBE
64.68
41%
-52
- C6 -
-
4V04
6
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
--
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
160
Blastp_CBE
64.69
44%
-63
- C6 -
-
4QQC
1
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
R
A
E
A
F
G
M
----------DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
--------------
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
130
Blastp_CBE
64.68
44%
-58
- C6 -
-
4R6V
1
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
R
A
E
A
F
G
M
----------DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
--------------
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
448
Blastp_CBE
64.60
39%
-59
- C6 -
-
3MSS
2
ABL1_MOUSE
A:
[4-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
393
Blastp_CBE
64.59
40%
-67
- C6 -
-
5AAC
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
---
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
404
Blastp_CBE
64.61
40%
-66
- C6 -
-
4CD0
1
A:
[41-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
261
Blastp_CBE
64.60
41%
-51
- C6 -
-
4NKA
2
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
------
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
294
Blastp_CBE
64.59
41%
-55
- C6 -
-
4RWJ
1
B:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
-------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
---------
Y
K
K
T
T
-
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
344
Blastp_CBE
64.57
40%
-73
- C6 -
-
5IUG
1
A:
[27-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
----
G
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-----------------
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
------------
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
370
Blastp_CBE
64.54
40%
-70
- C6 -
-
4CTC
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
----
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
360
Blastp_CBE
64.51
40%
-66
- C6 -
-
3AOX
5
A:
[43-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
----
G
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
162
Blastp_CBE
64.48
44%
-59
- C6 -
-
6IUO
1
?
A:
[30-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
R
A
E
A
F
G
M
-------
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
--------------
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
304
Blastp_CBE
64.42
40%
-69
- C6 -
-
5AA9
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
279
Blastp_CBE
64.41
41%
-64
- C6 -
-
6C19
1
B:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
192
Blastp_CBE
64.38
43%
-62
- C6 -
-
6NVK
1
A:
[13-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
----------------
S
S
E
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
374
Blastp_CBE
64.37
40%
-69
- C6 -
-
4CMU
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
377
Blastp_CBE
64.36
40%
-69
- C6 -
-
4CLI
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
446
Blastp_CBE
64.31
39%
-62
- C6 -
-
3MSS
2
ABL1_MOUSE
C:
[4-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
----
G
V
---
W
--
K
K
Y
S
--
L
---------
T
--
V
A
V
K
T
L
---------
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
--------
23
Blastp_CBE
64.34
49%
-35
- C6 -
-
6DKW
1
B:
[10-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
G
S
V
H
H
I
KR
R
D
I
VLKWEL
G
E
---
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
--------------
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
----------------
T
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
323
Blastp_CBE
64.32
40%
-65
- C6 -
-
5FTO
1
A:
[18-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
G
M
------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-------
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
120
Blastp_CBE
64.31
44%
-62
- C6 -
-
5JKG
1
A:
[19-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
---
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
G
P
-------------
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
107
Blastp_CBE
64.27
44%
-64
- C6 -
-
5XFF
1
A:
[19-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
G
P
-------------
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
235
Blastp_CBE
64.26
41%
-57
- C6 -
-
2FGI
1
B:
[17-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
196
Blastp_CBE
64.21
43%
-64
- C6 -
-
6NVG
1
A:
[13-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
P
G
----------------
S
S
E
G
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
259
Blastp_CBE
64.19
41%
-52
- C6 -
-
4NKS
1
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
-
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
315
Blastp_CBE
64.16
40%
-73
- C6 -
-
6MX8
1
A:
[17-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
---
G
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
---------------
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
-------------
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
265
Blastp_CBE
64.15
41%
-51
- C6 -
-
4F65
4
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
-----
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
-------
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
363
Blastp_CBE
64.09
41%
-53
- C6 -
-
6P68
1
C:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
354
Blastp_CBE
64.07
40%
-65
- C6 -
-
4TT7
5
A:
[17-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
----
G
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
----------------
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
--
R
K
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
359
Blastp_CBE
64.06
41%
-67
- C6 -
-
4ANS
1
A:
[41-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
--------
G
A
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
104
Blastp_CBE
64.01
41%
-86
- C6 -
-
2Z8C
1
A:
[10-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
N
A
R
D
I
---
I
--
K
G
E
A
--
E
---------
T
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
P
E
A
E
---------------
N
N
P
G
R
----
P
--
P
--
P
T
L
Q
E
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
---
R
K
G
G
K
G
--
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
K
-
F
V
M
D
-----
G
--
G
---
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
------------
288
Blastp_CBE
63.99
41%
-54
- C6 -
-
4WUN
1
FGFR1_HUMAN
A:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
--
L
E
Y
S
Y
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
378
Blastp_CBE
63.98
40%
-70
- C6 -
-
4CCU
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
---
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
541
Blastp_CBE
63.91
40%
-34
- C6 -
-
3GQI
2
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
F
S
F
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
254
Blastp_CBE
63.97
41%
-53
- C6 -
-
4V01
6
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
----
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
---------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
382
Blastp_CBE
63.91
40%
-68
- C6 -
-
2YFX
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
--------
G
A
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
368
Blastp_CBE
63.94
40%
-67
- C6 -
-
5KZ0
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
289
Blastp_CBE
63.92
41%
-57
- C6 -
-
5ZV2
1
B:
[13-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
--------------
P
E
E
Q
L
S
S
K
D
L
----------
V
S
C
A
------
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------
D
Y
Y
K
K
T
-----
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
303
Blastp_CBE
63.91
40%
-66
- C6 -
-
5AAA
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
376
Blastp_CBE
63.89
40%
-69
- C6 -
-
4CMO
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
239
Blastp_CBE
63.92
41%
-54
- C6 -
-
1AGW
1
B:
[17-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
267
Blastp_CBE
63.91
41%
-56
- C6 -
-
4F64
3
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
186
Blastp_CBE
63.89
40%
-26
- C6 -
-
6GWR
12
DDR1_HUMAN
A:
[5-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
S
L
D
--
F
PLGHP----
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
A
A
E
-----QG--
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
135
Blastp_CBE
63.83
44%
-57
- C6 -
-
5NUD
1
FGFR4_HUMAN
A:
[15-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
--
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
----------------------
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
-----------------
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
284
Blastp_CBE
63.80
41%
-53
- C6 -
-
5UR1
1
FGFR1_HUMAN
A:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
-
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------
Y
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
324
Blastp_CBE
63.77
40%
-75
- C6 -
-
2XBA
1
A:
[18-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
-------------
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
----------
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
419
Blastp_CBE
63.72
38%
-62
- C6 -
-
3IK3
1
ABL1_MOUSE
A:
[2-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
G
G
Q
Y
G
E
V
Y
--
E
G
-----------
V
W
K
K
--
Y
---------
S
L
T
V
A
V
K
T
L
K
E
D
T
M
E
--
V
E
E
-
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
-------------------------------
S
A
V
V
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
325
Blastp_CBE
63.71
40%
-73
- C6 -
-
2XB7
1
A:
[18-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
--------------
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
379
Blastp_CBE
63.69
40%
-72
- C6 -
-
4CCB
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
----------------
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
275
Blastp_CBE
63.67
41%
-59
- C6 -
-
6C1C
1
B:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
-
F
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
369
Blastp_CBE
63.59
40%
-80
- C6 -
-
5IMX
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
---------
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
----------
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
8
PsiBlast_PDB
63.62
48%
-39
- C6 -
-
5JFS
1
A:
[10-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
G
S
V
H
H
I
KR
R
D
I
VLKWEL
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
--------------------
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
371
Blastp_CBE
63.61
40%
-70
- C6 -
-
4CTB
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
---
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
9
PsiBlast_PDB
63.59
48%
-38
- C6 -
-
5JFV
1
A:
[10-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
G
S
V
H
H
I
KR
R
D
I
VLKWEL
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
--------------------
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
280
Blastp_CBE
63.58
41%
-59
- C6 -
-
6C19
1
FGFR1_HUMAN
A:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
----
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
---
E
Y
S
Y
N
P
S
---
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
334
Blastp_CBE
63.57
41%
-60
- C6 -
-
3TT0
4
B:
[65-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
---------
187
Blastp_CBE
63.45
40%
-19
- C6 -
-
4CKR
6
A:
[5-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
S
L
D
--
F
PLNVRKGHP
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
-------------
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
------
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
357
Blastp_CBE
63.43
40%
-76
- C6 -
-
6E0R
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
----
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
269
Blastp_CBE
63.39
41%
-54
- C6 -
-
4F63
3
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
-
G
Q
V
V
--
L
A
E
A
I
G
L
---------
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
Y
K
K
---
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
340
Blastp_CBE
63.38
40%
-73
- C6 -
-
4DCE
1
B:
[33-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
----
E
V
Y
--
E
G
Q
V
S
--------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
---------------
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
283
Blastp_CBE
63.37
41%
-56
- C6 -
-
5UR1
1
B:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
478
Blastp_CBE
63.33
38%
-21
- C6 -
-
5EG3
1
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
--------
P
-
G
-------
N
R
V
P
E
----
E
--
Q
--
M
T
F
K
D
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
F
F
K
E
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
185
Blastp_CBE
63.29
40%
-34
- C6 -
-
6GWR
8
B:
[5-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
S
-----P--------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
A
A
------G---
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
317
Blastp_CBE
63.21
41%
-20
- C6 -
-
4J99
1
?
C:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
M
E
Y
S
Y
D
-------
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
183
Blastp_CBE
63.22
40%
-47
- C6 -
-
6HP9
1
B:
[5-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
---------HP-------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
---------G---
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
211
Blastp_CBE
63.21
41%
-22
- C6 -
-
4K33
1
A:
[32-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
S
R
A
R
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
I
G
I
DKD
R
--
A
A
K
P
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
D
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
G
G
P
L
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
--------
P
-
G
L
D
Y
S
F
D
T
S
--------
E
--
Q
--
L
T
F
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
V
H
N
L
D
Y
Y
K
E
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
V
----------
301
Blastp_CBE
63.19
41%
-49
- C6 -
-
3GQL
1
FGFR1_HUMAN
B:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
------------
P
E
E
Q
L
S
S
K
D
L
----------
V
S
C
A
------
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
10
PsiBlast_PDB
63.18
48%
-36
- C6 -
-
5JFW
1
A:
[10-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
G
S
V
H
H
I
KR
R
D
I
VLKWEL
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
--------------------
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
343
Blastp_CBE
63.17
40%
-74
- C6 -
-
5IUH
1
A:
[27-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
-----------
G
E
V
Y
--
E
G
Q
V
S
G
-----------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
----------------
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
-------------
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
302
Blastp_CBE
63.06
41%
-43
- C6 -
-
3GQL
1
FGFR1_HUMAN
A:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
--------------
E
Q
L
S
S
K
D
L
----------
V
S
C
A
------
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------------
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
12
PsiBlast_PDB
63.07
48%
-39
- C6 -
-
6DKW
1
NTRK1_HUMAN
A:
[10-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
G
S
V
H
H
I
KR
R
D
I
VLKWEL
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
----------
D
A
K
L
L
A
G
G
E
D
-------
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
163
Blastp_CBE
63.06
42%
-89
- C6 -
-
1K3A
1
A:
[6-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
--
R
E
L
------
G
Q
G
S
F
G
M
V
Y
--
E
G
V
A
K
G
V
---
V
--
K
D
E
P
--
E
---------
T
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
-
H
-
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P
E
M
-------------------------------
P
S
L
S
K
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
---
R
K
G
G
K
G
--
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
----
R
-
F
V
M
E
-----
G
--
G
---
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
-----------------
549
Blastp_CBE
62.95
40%
-54
- C6 -
-
6BRJ
1
DDR1_HUMAN
A:
[568-868]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
---------------------------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
-------------
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
318
Blastp_CBE
62.93
41%
-20
- C6 -
-
4J99
1
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
M
E
Y
S
Y
D
-------
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
282
Blastp_CBE
62.90
41%
-49
- C6 -
-
6C18
1
FGFR1_HUMAN
A:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
----
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
---
S
Y
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
355
Blastp_CBE
62.89
40%
-74
- C6 -
-
6EDL
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
---
G
E
V
Y
--
E
G
Q
V
S
--------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
----------------
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
189
Blastp_CBE
62.87
40%
-17
- C6 -
-
4BKJ
10
DDR1_HUMAN
A:
[5-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
S
L
D
--
F
PLNVRKGHP
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
-------------
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
----
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
108
Blastp_CBE
62.85
44%
-63
- C6 -
-
5XFJ
1
A:
[19-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
R
A
E
A
F
G
M
---
D
--
P
A
R
P
DQ
A
---------
S
T
-
V
A
V
K
M
L
K
D
---
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
-
K
-
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
M
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
P
------
P
G
P
-------------
P
----------
L
S
F
P
V
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
S
-
L
L
R
E
-----
G
--
H
---
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
D
K
V
----------
373
Blastp_CBE
62.82
40%
-71
- C6 -
-
4CNH
1
ALK_HUMAN
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------------
E
V
Y
--
E
G
Q
V
---------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
345
Blastp_CBE
62.78
40%
-68
- C6 -
-
4FNZ
1
A:
[27-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
---
G
E
V
Y
--
E
G
Q
V
S
G
-------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
---------------
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
392
Blastp_CBE
62.80
40%
-65
- C6 -
-
4FOB
1
A:
[53-326]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
G
A
F
G
E
V
Y
--
E
G
Q
V
S
--------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
----------------
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
------
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
181
Blastp_CBE
62.78
40%
-39
- C6 -
-
5FDX
6
DDR1_HUMAN
A:
[28-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
------HP-------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
----------G---
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
188
Blastp_CBE
62.77
40%
-10
- C6 -
-
4BKJ
10
B:
[5-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
S
L
D
--
F
PLNVRKGHP
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
--------G---
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
----
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
182
Blastp_CBE
62.77
40%
-46
- C6 -
-
5FDP
7
A:
[28-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
-------------HP-------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
A
A
------G---
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
496
Blastp_CBE
62.68
41%
-20
- C6 -
-
5UGX
1
FGFR2_HUMAN
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
M
E
Y
S
Y
D
I
N
R
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
380
Blastp_CBE
62.72
40%
-71
- C6 -
-
2XP2
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
--------
G
A
F
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
----------------
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
375
Blastp_CBE
62.68
40%
-71
- C6 -
-
4CMT
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
---
G
E
V
Y
--
E
G
Q
V
-------------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
----------------
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
276
Blastp_CBE
62.68
41%
-53
- C6 -
-
6C1C
1
FGFR1_HUMAN
A:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-----
S
Y
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
127
Blastp_CBE
62.68
41%
-38
- C6 -
-
6FIL
1
A:
[12-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
---------------P--------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
A
A
E
G
A
P
G
D
----
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
190
Blastp_CBE
62.53
40%
-6
- C6 -
-
3ZOS
3
B:
[5-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
S
L
D
--
F
PLNVRKGHP
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
--------QG--
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
274
Blastp_CBE
62.42
41%
-58
- C6 -
-
6C1O
1
FGFR1_HUMAN
A:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
------
Y
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
337
Blastp_CBE
62.38
41%
-19
- C6 -
-
4J96
1
FGFR2_HUMAN
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
M
E
Y
S
Y
D
I
N
R
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
341
Blastp_CBE
62.39
40%
-65
- C6 -
-
4DCE
1
ALK_HUMAN
A:
[33-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
---
G
E
V
Y
--
E
G
Q
V
S
-----------
P
--
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-------------
S
Q
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
--------------
G
G
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
312
Blastp_CBE
62.38
41%
-52
- C6 -
-
6MZW
1
FGFR1_HUMAN
A:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
N
P
S
--
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
191
Blastp_CBE
62.35
40%
-4
- C6 -
-
3ZOS
4
DDR1_HUMAN
A:
[5-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
S
L
D
--
F
PLNVRKGHP
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
---------AAQG
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
533
Blastp_CBE
62.25
40%
-75
- C6 -
-
3DPK
1
A:
[42-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
--
K
T
L
------
G
A
G
A
F
G
K
V
V
--
E
A
T
A
F
G
L
---
G
-----
A
--
V
---------
L
K
-
V
A
V
K
M
L
K
S
T
A
H
A
D
E
K
E
A
-
L
M
S
E
L
K
I
M
S
H
L
G
Q
-
H
-
E
-
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
R
R
---------------------------------
Q
--
L
S
S
R
D
L
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
---
T
N
G
H
V
A
K
I
G
D
F
G
L
A
R
D
I
M
N
D
S
N
Y
I
V
------
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
----
Y
K
L
V
K
D
-----
G
--
Y
---
Q
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
E
-----------
424
Blastp_CBE
62.30
41%
-27
- C6 -
-
5UHN
1
FGFR2_HUMAN
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
-----------------
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
409
Blastp_CBE
62.28
40%
-76
- C6 -
-
4FNY
1
A:
[27-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
---
G
E
V
Y
--
E
G
Q
V
S
G
-----------------------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
-----------------
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
----------------
C
A
--
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
278
Blastp_CBE
62.25
41%
-61
- C6 -
-
6C1B
1
FGFR1_HUMAN
A:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
-----------
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
----------------------
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
539
Blastp_CBE
62.23
38%
-28
- C6 -
-
4XEY
1
ABL1_HUMAN
B:
[101-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
P
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------------
E
V
Y
--
E
G
-----------
V
W
K
K
--
Y
---------
S
L
T
V
A
V
K
T
L
---
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
286
Blastp_CBE
62.21
41%
-66
- C6 -
-
5UQ0
1
FGFR1_HUMAN
A:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
--
F
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
---------------------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
-
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
287
Blastp_CBE
62.19
41%
-63
- C6 -
-
4WUN
1
B:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
--------
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
---------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
198
Blastp_CBE
62.19
40%
-34
- C6 -
-
5BVW
1
A:
[15-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
----------------HP-------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
------------
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
----
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
320
Blastp_CBE
62.18
41%
-21
- C6 -
-
4J98
1
FGFR2_HUMAN
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
M
E
Y
S
Y
D
I
N
R
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
Q
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
11
PsiBlast_PDB
62.14
48%
-35
- C6 -
-
5JFX
1
A:
[10-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
G
S
V
H
H
I
KR
R
D
I
VLKWEL
G
E
G
A
F
G
K
V
F
--
L
A
E
C
H
N
L
---
L
--
P
E
Q
D
--
K
---------
M
L
-
V
A
V
K
A
L
K
E
-
A
S
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
-
Q
-
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
H
G
P
--------------------
V
A
P
----
G
--
P
--
L
G
L
G
Q
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
Q
G
L
V
V
K
I
G
D
F
G
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
Y
-
G
K
Q
P
W
Y
Q
L
S
N
T
E
A
I
----
D
-
C
I
T
Q
-----
G
--
R
---
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
--------
124
Blastp_CBE
62.07
41%
-32
- C6 -
-
6FIQ
1
A:
[11-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
-------------P--------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
A
A
E
G
A
P
G
D
----
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
406
Blastp_CBE
62.02
41%
-25
- C6 -
-
5UGL
1
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
---------------
R
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
271
Blastp_CBE
62.04
41%
-60
- C6 -
-
6MZQ
1
B:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
-----------------------------------
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
---------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
200
Blastp_CBE
62.02
40%
-33
- C6 -
-
5BVN
1
A:
[15-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
----------------HP-------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
------------
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
129
Blastp_CBE
61.90
41%
-22
- C6 -
-
6FEW
1
A:
[11-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
S
-----VRKGHP---
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
A
A
----------
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
272
Blastp_CBE
61.86
41%
-46
- C6 -
-
6MZQ
1
FGFR1_HUMAN
A:
[18-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
N
P
S
---
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
427
Blastp_CBE
61.79
41%
-20
- C6 -
-
5UI0
1
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
M
E
Y
S
Y
D
I
N
R
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
305
Blastp_CBE
61.69
41%
-52
- C6 -
-
6NVL
1
D:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
--------------
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
--
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
--
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
E
Y
S
Y
N
P
S
H
N
P
E
----
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
---------
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
397
Blastp_CBE
61.62
41%
-23
- C6 -
-
3RI1
1
?
A:
[20-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
----------------
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
425
Blastp_CBE
61.61
41%
-23
- C6 -
-
2PY3
1
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
----
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
-----------
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
128
Blastp_CBE
61.59
41%
-13
- C6 -
-
6FEX
2
A:
[11-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
-----
F
PLNVRKGHP
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
---------
D
----
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
260
Blastp_CBE
61.52
41%
-51
- C6 -
-
4NKS
1
FGFR1_HUMAN
A:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
-----------
G
Q
V
V
--
L
A
E
A
I
------------NR
V
---------
T
K
-
V
A
V
K
M
L
K
-
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
---------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
316
Blastp_CBE
61.46
41%
-21
- C6 -
-
4J99
1
?
D:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
-------------------
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
T
---
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
273
Blastp_CBE
61.39
41%
-56
- C6 -
-
6C1O
1
B:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
--
F
G
Q
V
V
--
L
A
E
A
I
G
L
--------
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
346
Blastp_CBE
61.36
41%
-29
- C6 -
-
4J95
2
?
D:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
-------------------
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-----------
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
311
Blastp_CBE
61.37
41%
-58
- C6 -
-
6MZW
1
B:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
-----------
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
----------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
201
Blastp_CBE
61.36
40%
-29
- C6 -
-
5BVK
1
A:
[15-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
----------------HP-------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
------------
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
396
Blastp_CBE
61.35
41%
-22
- C6 -
-
3RI1
1
FGFR2_HUMAN
B:
[20-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
M
A
E
A
V
G
I
D-----
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
----------------
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
395
Blastp_CBE
61.31
40%
-58
- C6 -
-
6FEK
3
A:
[19-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
------------------
S
R
K
V
G
P
G
P
----
D
ER
A
--
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
F
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
281
Blastp_CBE
61.29
41%
-55
- C6 -
-
6C18
1
B:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
----
G
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
----------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
306
Blastp_CBE
61.21
41%
-60
- C6 -
-
6NVL
1
FGFR1_HUMAN
C:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
-----------
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
-----
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
--
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
-------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
----
H
H
I
D
Y
Y
K
K
T
-------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
347
Blastp_CBE
61.10
41%
-22
- C6 -
-
4J95
1
?
C:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
-------------------
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
300
Blastp_CBE
60.99
41%
-48
- C6 -
-
3GQL
1
C:
[24-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
L
A
E
A
I
G
L
---
D
--
K
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
P
--------------
E
Q
L
S
S
K
D
L
----------
V
S
C
A
------
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
331
Blastp_CBE
60.97
41%
-24
- C6 -
-
4J97
1
?
C:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
---
F
G
Q
V
V
--
M
A
E
A
V
G
I
D-------
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
-------
I
N
R
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
199
Blastp_CBE
60.96
40%
-31
- C6 -
-
5BVO
1
A:
[15-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
--
F
G
E
V
H
LC
E
V
D
S
----------------HP-------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
------------
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
184
Blastp_CBE
60.90
40%
-8
- C6 -
-
6HP9
1
DDR1_HUMAN
A:
[5-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
S
L
D
--
F
PLNVRKGHP
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
----------QG--
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
540
Blastp_CBE
60.77
38%
-23
- C6 -
-
4XEY
1
ABL1_HUMAN
A:
[116-385]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
D
K
W
E
M
E
R
T
D
I
T
M
K
--
H
K
L
------
G
----
G
E
V
Y
--
E
G
-----------
V
W
K
K
--
Y
---------
S
L
T
V
A
V
K
T
L
K
E
D
T
---
M
E
V
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
-
P
-
N
L
V
Q
L
L
G
V
C
T
R
E
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
R
Q
E
V
N
A
V
V
-------------------------------
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
Y
T
A
H
A
G
A
--
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
----
E
-
L
L
E
K
-----
D
--
Y
---
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
------
326
Blastp_CBE
60.83
41%
-20
- C6 -
-
2PWL
1
FGFR2_HUMAN
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
------------
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
332
Blastp_CBE
60.77
41%
-21
- C6 -
-
4J97
1
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
M
A
E
A
V
G
I
D-------
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
------
I
N
R
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
307
Blastp_CBE
60.78
41%
-58
- C6 -
-
6NVL
1
FGFR1_HUMAN
B:
[16-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
-------------
Q
V
V
--
L
A
E
A
I
G
L
-------
D
K
P
NR
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P
--------
P
-
G
L
---------------
E
--
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
125
Blastp_CBE
60.77
41%
-1
- C6 -
-
6FIO
1
A:
[11-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
S
L
D
--
F
PLNVRKGHP
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
A
A
E
G
A
--
D
----
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
356
Blastp_CBE
60.75
40%
-64
- C6 -
-
6EBW
1
A:
[26-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
H
--
F
G
E
V
Y
--
E
G
Q
V
S
--------------
S
---------
P
L
Q
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
P
---------------
P
S
S
-------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
----------------
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
405
Blastp_CBE
60.68
41%
-30
- C6 -
-
5UGL
1
?
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-------------------
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
-----------
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
426
Blastp_CBE
60.60
41%
-20
- C6 -
-
2PY3
1
FGFR2_HUMAN
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
----------
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
333
Blastp_CBE
60.45
41%
-25
- C6 -
-
4J97
1
FGFR2_HUMAN
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
M
A
E
A
V
G
I
D--
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
----------
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
440
Blastp_CBE
60.38
40%
-17
- C6 -
-
3B2T
1
FGFR2_HUMAN
A:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
C
F
G
Q
V
V
--
M
A
E
A
V
G
I
D-----
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-----------------
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
327
Blastp_CBE
60.29
41%
-19
- C6 -
-
2PWL
1
FGFR2_HUMAN
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
-----------------
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
423
Blastp_CBE
60.28
41%
-32
- C6 -
-
5UHN
2
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
-------------------
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-----------
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
319
Blastp_CBE
60.23
41%
-25
- C6 -
-
4J99
1
FGFR2_HUMAN
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------------------
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
--
D
Y
Y
K
--
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
310
Blastp_CBE
60.23
41%
-19
- C6 -
-
2PZP
1
FGFR2_HUMAN
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------------
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
E
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
353
Blastp_CBE
60.16
41%
-21
- C6 -
-
2PVY
1
?
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------------
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
M
----
D
I
N
R
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
548
Blastp_CBE
60.11
40%
-31
- C6 -
-
6BSD
1
DDR1_HUMAN
A:
[567-868]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
----------------P--------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
A
-------G---
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
--
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
348
Blastp_CBE
60.02
41%
-21
- C6 -
-
4J95
1
?
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------------------
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
495
Blastp_CBE
59.96
41%
-21
- C6 -
-
5UGX
1
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
M
-----
I
N
R
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
----------
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
180
Blastp_CBE
60.00
40%
-38
- C6 -
-
5FDX
5
B:
[29-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
----------------P--------
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
A
-------G---
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
126
Blastp_CBE
59.98
41%
-2
- C6 -
-
6FIN
1
A:
[11-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
D
F
P
R
S
R
L
R
F
K
--
E
K
L
------
G
E
G
Q
F
G
E
V
H
LC
E
V
D
S
P
Q
D
---
L
--
V
S
-----PLNVRKGHP
L
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
-
P
-
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----------
S
A
H
-
Q
L
E
D
K
A
A
----------
P
--
T
--
I
S
Y
P
M
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
--
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
ENAG
E
-
F
F
R
D
-----
Q
--
G
RQV
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-------------
309
Blastp_CBE
59.96
41%
-25
- C6 -
-
2PZP
1
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------------
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
E
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
-----------
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
202
Blastp_CBE
59.94
42%
-51
- C6 -
-
4UEU
1
?
A:
[7-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
--
R
K
L
------
G
S
G
Q
F
G
E
V
Y
--
E
G
K
-----------
W
R
N
--
Y
---------
N
I
E
V
A
V
K
T
L
K
E
G
T
M
S
--
V
E
E
-
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
-
P
-
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
E
G
H
T
V
N
A
Q
A
L
L
-
D
M
------------------------------
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-----------
A
--
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
----
E
-
Q
V
E
R
-----
G
--
Y
---
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
----------
349
Blastp_CBE
59.81
41%
-20
- C6 -
-
4J95
1
FGFR2_HUMAN
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
------------------
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
----
Y
Y
K
N
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
387
Blastp_CBE
59.75
41%
-26
- C6 -
-
2PZR
1
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------------
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---------------
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
R
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
329
Blastp_CBE
59.62
41%
-20
- C6 -
-
2PZ5
1
FGFR2_HUMAN
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------------
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
T
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
----------------
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
384
Blastp_CBE
59.32
40%
-81
- C6 -
-
4JOA
1
A:
[44-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
P
R
K
N
I
T
L
I
--
R
G
L
------
G
------
V
Y
--
E
G
Q
V
S
-------------------------
L
Q
V
A
V
K
T
L
P
---------
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
-
Q
-
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
P
R
--------------------------------
L
A
M
L
D
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
----------
A
--
M
L
P
V
K
W
M
P
P
E
A
---
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
----
E
-
F
V
T
S
-----
G
--
G
---
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
---
I
L
E
R
I
----------
543
Blastp_CBE
59.31
40%
-66
- C6 -
-
5FM2
1
A:
[53-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
-
A
K
G
S
L
R
G
F
L
R
E
S
R
----------------------------------
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
--
R
Q
G
--
R
I
P
V
K
W
M
A
I
E
S
L
F
-
D
H
I
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
328
Blastp_CBE
59.22
41%
-25
- C6 -
-
2PZ5
1
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------------
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
T
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
-------------
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
352
Blastp_CBE
59.21
41%
-33
- C6 -
-
2PVY
1
?
B:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------------
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
-----
D
I
N
R
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
--
Y
Y
K
----
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
330
Blastp_CBE
59.01
41%
-22
- C6 -
-
4J97
1
?
D:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
-----------
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
---------
R
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
439
Blastp_CBE
58.96
40%
-20
- C6 -
-
3B2T
1
B:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
----------
F
G
Q
V
V
--
M
A
E
A
V
G
I
D--
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
P
-----------------
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
350
Blastp_CBE
58.96
41%
-23
- C6 -
-
2PVY
1
?
D:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------------
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
---------
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
351
Blastp_CBE
58.90
41%
-30
- C6 -
-
2PVY
1
?
C:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------------
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
K
E
A
--
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
M
E
-------
V
P
E
E
Q
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
--
Y
Y
K
---
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
203
Blastp_CBE
58.58
42%
-57
- C6 -
-
4CSV
1
?
A:
[7-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
--
R
K
L
------
G
S
G
Q
F
G
E
V
Y
--
E
G
K
-----------
W
R
N
--
Y
---------
N
I
E
V
A
V
K
T
L
K
E
G
T
M
S
--
V
E
E
-
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
-
P
-
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
C
----
V
N
A
Q
A
L
L
-
D
M
------------------------------
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
E
N
N
V
V
K
V
A
D
F
G
--------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
----
E
-
Q
V
E
R
-----
G
--
Y
---
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
T
L
H
A
L
E
T
M
----------
285
Blastp_CBE
58.30
41%
-27
- C6 -
-
5UQ0
1
B:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
L
A
E
A
I
G
L
----------R-
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
--
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
277
Blastp_CBE
57.75
41%
-28
- C6 -
-
6C1B
1
B:
[18-303]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
R
D
R
L
V
L
G
--
K
P
L
------
G
E
---
G
Q
V
V
--
L
A
E
A
I
------------R-
V
---------
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
Q
--
L
S
S
K
D
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
542
Blastp_CBE
57.38
40%
-67
- C6 -
-
5FM3
1
A:
[53-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
---
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
-
A
K
G
S
L
R
G
F
L
R
E
S
R
----------------------------------
L
T
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
--
R
Q
G
--
R
I
P
V
K
W
M
A
I
E
S
L
F
-
D
H
I
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
557
Blastp_CBE
53.21
40%
-19
- C6 -
-
2PVF
1
A:
[31-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
D
K
L
T
L
G
--
K
P
L
------
G
E
G
A
F
G
Q
V
V
--
M
A
E
A
V
G
I
DKD
K
--
P
-----
V
---------
T
--
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
-
K
-
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
R
R
P
---
P
G
M
E
S
Y
-
D
--------
M
T
F
K
----
D
--
L
--
V
S
C
T
Y
Q
L
------
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
--
K
K
T
T
N
G
--
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
----
K
-
L
L
K
E
-----
G
--
H
---
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
----------
212
Blastp_CBE
43.59
40%
-1
- C6 -
-
2IVV
3
A:
[5-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
D
P
K
W
I
--
E
F
P
R
K
N
L
V
L
G
--
K
T
L
------
G
E
G
E
F
G
K
V
V
--
K
A
T
A
F
H
L
---
K
--
G
R
A
G
--
Y
---------
T
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
-
P
-
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K
V
----------------------------------
M
G
D
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
S
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
V
K
R
S
Q
G
---
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
----
N
-
L
L
K
T
-----
G
--
H
---
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
----------
-
* C *
-
-
:
------------------------------------------------------------------