@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : NEK1_HUMAN: (2020-09-17 )
MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISEEAARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGEVKAPFLGSGGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWKREIYGRGLPERGILPGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQRKREAMQNKARAEGHMVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAKGVKSSDVSPPLGQHETGGSPSKQQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHEDAKEHEKEKSVSSDRKKWEAGGQLVIPLDELTLDTSFSTTERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEGEKYKPLITGEKKVQCISHEINPSAIVDSPVETKSPEFSEASPQMSLKLEGNLEEPDDLETEILQEPSGTNKDESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGVSSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFRSHSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIASECECDSVFNHLEELRLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE
Atome Classification :
(66 SA)
------------------------------------------------------------------------.........10........20........30........40-.-.-....-..50........60........70-.........80........90.......----.100-----........110.......120.-----......130.......140.......150..--......-160.......170..--..---..-----.180.......190.......200..-.......210....----..--.--220.--.--..---.---...230.......-----240.......250----........260-----.......270.......280.......290.......300...--....310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
------------------------------------------------------------------------MEK
Y
V
R
L
Q
KIGEGSFG
K
A
I
L
V
K
STEDGR
Q
Y
V
I
K
EI
N
I
S
RMS-
S
-
K
-
E
R
E
E
-
S
R
R
E
V
A
V
L
ANMKHP
N
I
V
Q
Y
R
E
S
F
--EENG
S
L
Y
I
V
M
D
YCEG
G
D
L
F
K
R
INAQKG
V
----
L
FQ------E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
VH
D
R
K
-----
I
L
H
R
DIKSQ
N
I
F
LTKDG
T
V
Q
L
G
D
F
G
I
A
-
R
V
L
--
N
S
T
V
E
L
-
A
R
T
CIGTPYYL
S
P
E
I
--CE---NK-----PYNNK
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
--
H
A
-
F
EAG
S
M
K
N
L
V
L
K
I
I----SG--S--FP-
P
--
V
--
S
L
---
H
---YSY
D
L
R
S
L
V
S
Q
L
F
-----KRNPRDR
P
S
V
N
S
-----
I
L
E
K
G
F
I
A
K
R
I
-----
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
FGSQPIPAKRPASGQN
S
I
S
VM
P
A
--
Q
K
ITK
P
A
A
KYGIP
L
A
Y
K
KYGDKKLHEKKP
L
Q
K
H
K
Q
A
HQ
T
P
E
KRVN
T
G
E
E
R
R
K
I
S
E
E
A
A
R
K
R
R
L
E
F
I
E
K
E
K
K
Q
K
D
Q
I
I
S
L
M
K
A
E
Q
M
K
R
Q
E
K
E
R
L
E
R
I
N
R
A
R
E
Q
G
W
R
N
V
L
SAGGSGEVKA
P
F
LGSGGTIAPSSFSSRGQ
Y
E
H
Y
H
A
I
F
D
Q
M
Q
Q
Q
RAED
N
E
A
K
W
K
R
E
I
YGRGLPERGILPGVRPGFPYGAAGHHHFP
D
A
D
D
I
R
K
T
L
K
R
L
K
A
V
S
K
QANANRQK
G
Q
L
A
V
E
R
A
K
Q
V
E
E
F
L
Q
R
K
R
E
A
M
Q
N
K
ARAEG
H
M
V
Y
L
A
R
L
R
Q
I
R
L
QNF
N
E
R
Q
Q
I
K
A
K
LRGEKKEANHSEGQEG
S
E
E
A
D
M
R
R
K
K
I
E
S
L
K
A
HA
N
A
R
A
A
V
L
K
E
Q
L
E
R
K
R
K
E
A
Y
E
R
E
K
K
V
W
E
E
H
L
V
AKGVKSSDVSPPLGQHETGGS
P
S
K
Q
Q
M
R
S
V
I
S
V
T
S
A
L
K
EVGVDSSLTD
T
R
E
T
S
E
E
M
Q
K
TNNA
I
S
S
K
R
E
I
L
R
R
L
N
E
NLKAQEDEKGKQNLSD
T
F
E
I
N
VHE
D
A
K
E
H
E
K
E
KSVSS
D
R
K
K
WEAG
G
Q
L
V
I
P
L
D
E
L
T
LDTSFSTTERHTVG
E
V
I
K
LGPNGSPRRAWGKSP
T
D
S
V
L
K
I
L
G
E
A
E
L
Q
L
Q
T
E
L
LENTTIRSEISPEGEKYKPLITGE
K
K
V
Q
C
I
SHEI
N
P
S
A
IVDSPVETKSPEFSEASP
Q
M
S
L
K
LEGNLEEPD
D
L
E
T
E
I
LQEPSGTNKDESL
P
C
T
I
T
D
V
WISEEKETKETQSA
D
R
I
T
I
QENEVSED
G
V
S
S
T
V
D
Q
L
S
D
I
H
IEPGTNDSQHSKCDVDKSVQP
E
P
F
F
H
K
V
V
H
S
E
HLNLVPQ
V
Q
SVQCSPEE
S
F
AFRSHSHLPPKNKNK
N
S
L
L
I
G
LSTGLFDANNP
K
M
L
R
TCS
L
P
D
L
S
K
L
F
R
T
L
MDVPTVGDVRQDNLEIDEIEDENIKEGPSDSE
D
I
V
FEETDT
D
L
Q
E
L
Q
A
S
M
E
Q
L
L
R
EQPGEEY
S
E
E
E
E
S
V
LKNSDVEPTANGTDVADEDDNPSSESALNEEWHSDNSDGEIASEC
E
C
D
S
V
F
N
H
L
E
E
L
R
L
H
L
E
Q
EM
G
F
E
K
F
F
E
V
Y
E
K
I
K
A
I
HEDEDE
N
I
E
I
C
S
K
I
V
Q
N
I
LGN
E
H
Q
H
L
Y
A
K
I
L
H
L
V
MADGAYQEDNDE
21
Blastp_CBE
95.09
99%
-133
- C2 -
-
4B9D
2
NEK1_HUMAN
B:
[23-306]
------------------------------------------------------------------------
M
E
K
Y
V
R
L
Q
K
I
G
-----
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
-
S
-
K
-
E
R
E
E
-
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
G
V
----
L
F
Q
------
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
I
A
-
R
V
L
--
N
S
T
V
E
L
-
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
--
C
E
---
N
K
-----
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
--
H
A
-
F
E
A
G
S
M
K
N
L
V
L
K
I
I
----
S
G
--
S
--
F
P
-
P
--
V
--
S
L
---
H
---
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
-----
K
R
N
P
R
D
R
P
S
V
N
S
-----
I
L
E
K
G
F
I
A
K
R
I
-----
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
HHSearch
94.29
100%
-130
- C2 -
-
4APC
-
NEK1_HUMAN
B:
[24-306]
-------------------------------------------------------------------------
E
K
Y
V
R
L
Q
K
I
-----
G
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
-
S
-
K
-
E
R
E
E
-
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
G
V
----
L
F
Q
------
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
I
A
-
R
V
L
--
N
S
T
V
E
L
-
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
--
C
E
---
N
K
-----
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
--
H
A
-
F
E
A
G
S
M
K
N
L
V
L
K
I
I
----
S
G
--
S
--
F
P
-
P
--
V
--
S
L
---
H
---
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
-----
K
R
N
P
R
D
R
P
S
V
N
S
-----
I
L
E
K
G
F
I
A
K
R
I
-----
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.85
99%
-134
- C2 -
-
4APC
-
NEK1_HUMAN
A:
[23-306]
------------------------------------------------------------------------
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
-
S
-
K
-
E
R
E
E
-
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
G
V
----
L
F
Q
------
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
I
A
-
R
V
L
--
N
S
T
V
E
L
-
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
--
C
E
---
N
K
-----
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
--
H
A
-
F
E
A
G
S
M
K
N
L
V
L
K
I
I
----
S
G
--
S
--
F
P
-
P
--
V
--
S
L
---
H
---
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
-----
K
R
N
P
R
D
R
P
S
V
N
S
-----
I
L
E
K
G
F
I
A
K
R
I
-----
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.84
99%
-136
- C2 -
-
4B9D
1
NEK1_HUMAN
A:
[23-306]
------------------------------------------------------------------------
M
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
-
S
-
K
-
E
R
E
E
-
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
G
V
----
L
F
Q
------
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
I
A
-
R
V
L
--
N
S
T
V
E
L
-
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
--
C
E
---
N
K
-----
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
--
H
A
-
F
E
A
G
S
M
K
N
L
V
L
K
I
I
----
S
G
--
S
--
F
P
-
P
--
V
--
S
L
---
H
---
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
-----
K
R
N
P
R
D
R
P
S
V
N
S
-----
I
L
E
K
G
F
I
A
K
R
I
-----
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
HHSearch
93.67
100%
-136
- C2 -
-
4B9D
1
NEK1_HUMAN
A:
[24-306]
-------------------------------------------------------------------------
E
K
Y
V
R
L
Q
K
I
------
K
A
I
L
V
K
S
T
E
D
G
R
Q
Y
V
I
K
E
I
N
I
S
R
M
S
-
S
-
K
-
E
R
E
E
-
S
R
R
E
V
A
V
L
A
N
M
K
H
P
N
I
V
Q
Y
R
E
S
F
--
E
E
N
G
S
L
Y
I
V
M
D
Y
C
E
G
G
D
L
F
K
R
I
N
A
Q
K
G
V
----
L
F
Q
------
E
D
Q
I
L
D
W
F
V
Q
I
C
L
A
L
K
H
V
H
D
R
K
-----
I
L
H
R
D
I
K
S
Q
N
I
F
L
T
K
D
G
T
V
Q
L
G
D
F
G
I
A
-
R
V
L
--
N
S
T
V
E
L
-
A
R
A
C
I
G
T
P
Y
Y
L
S
P
E
I
--
C
E
---
N
K
-----
P
Y
N
N
K
S
D
I
W
A
L
G
C
V
L
Y
E
L
C
T
L
K
--
H
A
-
F
E
A
G
S
M
K
N
L
V
L
K
I
I
----
S
G
--
S
--
F
P
-
P
--
V
--
S
L
---
H
---
Y
S
Y
D
L
R
S
L
V
S
Q
L
F
-----
K
R
N
P
R
D
R
P
S
V
N
S
-----
I
L
E
K
G
F
I
A
K
R
I
-----
E
K
F
L
S
P
Q
L
I
A
E
E
F
C
L
K
T
F
S
K
F
G
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
577
Fugue
64.66
25%
7
- C2 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
SGEVRLRQLEQFILDGPAQTNGQCFSVETLLDILICLYDECNNSPLRREKNILEYLEWAKPFTSKVKQMRLH
R
E
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
-
K
-
R
-
A
E
T
A
C
F
R
E
E
R
D
V
L
V
N
G
D
S
K
W
I
T
T
L
H
Y
A
F
--
Q
D
D
N
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
----
L
-
P
------
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
L
H
-----
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
G
H
I
R
L
A
D
F
G
S
C
-
L
K
L
ME
D
G
T
V
Q
--
S
S
V
A
V
G
T
P
D
Y
I
S
P
E
I
--
L
Q
---
A
M
EGGKG
R
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
--
T
P
-
F
Y
A
E
S
L
V
E
T
Y
G
K
I
M
NHKE
R
F
--
Q
--
F
P
-
T
--
Q
--
V
T
---
D
---
V
S
E
N
A
K
D
L
I
R
R
L
I
-----
C
S
R
E
H
-
R
L
G
Q
N
G
-----
I
----------------
E
D
F
K
K
H
P
F
F
S
G
I
D
W
D
N
I
R
N
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
V
D
S
G
HH
L
P
F
V
G
F
T
Y
T
S
S
C
V
L
S
D
R
S
C
L
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
61.80
42%
-32
- C2 -
-
5M51
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
-
E
-
A
-
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
KERQ
Y
L
D
------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
DGGHT
V
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
--------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
M
-----
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
--
P
P
-
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
--
K
--
F
R
-
R
--
I
--
P
Y
---
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
-----
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
61.11
42%
-32
- C2 -
-
2W5A
5
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
-
E
-
A
-
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
KERQ
Y
L
D
------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
-
R
I
L
-----
T
S
F
-
A
K
T
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
M
------
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
--
P
P
-
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
--
K
--
F
R
-
R
--
I
--
P
Y
---
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
-----
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
60.77
42%
-28
- C2 -
-
2W5B
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
-
E
-
A
-
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
KERQ
Y
L
D
------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
------
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
-
R
I
L
--
N
H
D
T
S
F
-
A
K
A
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
M
-----
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
--
P
P
-
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
--
K
--
F
R
-
R
--
I
--
P
Y
---
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
-----
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
60.75
42%
-47
- C2 -
-
2JAV
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
-
E
-
A
-
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID----
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
KERQ
Y
L
D
------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
---------
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
-
R
I
L
--------------
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
M
-----
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
--
P
P
-
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
--
K
--
F
R
-
R
--
I
--
P
Y
---
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
-----
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
60.46
32%
-77
- C2 -
-
6HXF
1
STK10_HUMAN
A:
[27-294]
---------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
-----
E
-
E
-
E
L
E
D
-
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
----
G
L
T
------
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-----
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
K
-Q
K
R
D
F
I
G
T
P
Y
W
M
A
P
E
V
VM
C
E
---
M
K
DT---
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
--
P
P
-
H
H
E
L
N
P
M
R
V
L
L
K
-
I
----
A
K
--
S
--
D
P
-
P
--
T
--
L
L
TPS
K
---
W
S
V
E
F
R
D
F
L
K
I
A
L
-----
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
60.37
32%
-44
- C2 -
-
4B6L
1
PLK3_HUMAN
A:
[11-265]
---------------------------------------------------------------------------
Y
L
K
G
R
L
L
G
K
G
G
F
A
R
C
Y
E
A
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
P
Q
S
R
V
A
K
P
-
H
-
Q
R
E
K
-
I
L
N
E
I
E
L
H
R
D
L
Q
H
R
H
I
V
R
F
S
H
H
F
--
E
D
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
I
W
K
A
R
H
T
L
----
L
--------
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
R
G
-----
I
L
H
R
D
L
K
L
G
N
F
F
I
T
E
N
M
E
L
K
V
G
D
F
G
L
A
-
A
R
L
--
E
P
P
E
Q
R
-
K
K
T
I
C
G
T
P
N
Y
V
A
P
E
V
--
L
L
---
R
Q
-----
G
H
G
P
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
--
P
P
-
F
E
T
A
D
L
K
E
T
Y
R
C
I
K
----
Q
V
--
H
--
Y
T
L
P
--
A
--
S
L
--------
S
L
P
A
R
Q
L
L
A
A
I
L
-----
R
A
S
P
R
D
R
P
S
I
D
Q
-----
I
L
R
H
D
F
F
T
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
60.08
33%
-38
- C2 -
-
2F7X
1
KAPCA_BOVIN
E:
[41-292]
------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
R
I
G
----
R
F
S
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
--
G
R
T
-----
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
59.95
31%
-28
- C2 -
-
4I6H
1
PLK2_HUMAN
A:
[28-284]
-------------------------------------------------------------------------
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
-
K
P
H
-
Q
R
E
K
-
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
--
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
K
------
V
L
T
------
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
-----
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
-
A
R
L
--
E
P
L
E
H
R
-
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
--
L
N
---
K
Q
-----
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
--
P
P
-
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
----
E
A
--
R
--
Y
T
M
P
--
S
--
S
L
--------
L
A
P
A
K
H
L
I
A
S
M
L
-----
S
K
N
P
E
D
R
P
S
L
D
D
-----
I
I
R
H
D
F
F
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
59.93
42%
-26
- C2 -
-
5M57
1
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
-
E
-
A
-
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
KERQ
Y
L
D
------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
S
DGGHT
V
L
H
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
--------------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
M
-----
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
--
P
P
-
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
--
K
--
F
R
-
R
--
I
--
P
Y
---
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
-----
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
59.86
33%
-38
- C2 -
-
2OH0
1
KAPCA_BOVIN
E:
[41-292]
------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
R
I
G
----
R
F
S
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
--
G
R
T
-----
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
59.77
31%
-27
- C2 -
-
4I6B
1
PLK2_HUMAN
A:
[28-284]
-------------------------------------------------------------------------
K
R
Y
S
R
G
K
T
L
G
K
G
G
F
A
K
C
Y
E
M
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
P
H
S
R
V
S
-
K
P
H
-
Q
R
E
K
-
I
D
K
E
I
E
L
H
R
I
L
H
H
K
H
V
V
Q
F
Y
H
Y
F
--
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
I
L
K
A
R
K
------
V
L
T
------
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
Q
E
-----
I
L
H
R
D
L
K
L
G
N
F
F
I
N
E
S
M
E
L
K
V
G
D
F
G
L
A
-
A
R
L
--
E
P
L
E
H
R
-
R
R
T
I
C
G
T
P
N
Y
L
S
P
E
V
--
L
N
---
K
Q
-----
G
H
G
A
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
--
P
P
-
F
E
T
T
N
L
K
E
T
Y
R
S
I
R
----
E
A
--
R
--
Y
T
M
P
--
S
--
S
L
--------
L
A
P
A
K
H
L
I
A
S
M
L
-----
S
K
N
P
E
D
R
P
S
L
D
D
-----
I
I
R
H
D
F
F
T
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
59.72
42%
-31
- C2 -
-
2XNM
10
NEK2_HUMAN
A:
[6-271]
-------------------------------------------------------------------------
E
D
Y
E
V
L
Y
T
I
G
T
G
S
Y
G
R
C
Q
K
I
R
R
K
S
D
G
K
I
L
V
W
K
E
L
D
Y
G
S
M
T
-
E
-
A
-
E
K
Q
M
-
L
V
S
E
V
N
L
L
R
E
L
K
H
P
N
I
V
R
Y
Y
D
R
I
ID
R
T
N
T
T
L
Y
I
V
M
E
Y
C
E
G
G
D
L
A
S
V
I
T
--
K
G
T
KERQ
Y
L
D
------
E
E
F
V
L
R
V
M
T
Q
L
T
L
A
L
K
E
C
H
R
R
---------
R
D
L
K
P
A
N
V
F
L
D
G
K
Q
N
V
K
L
G
D
F
G
L
A
-
R
I
L
------------
F
V
G
T
P
Y
Y
M
S
P
E
Q
--
M
N
---
R
------
S
Y
N
E
K
S
D
I
W
S
L
G
C
L
L
Y
E
L
C
A
L
M
--
P
P
-
F
T
A
F
S
Q
K
E
L
A
G
K
I
R
----
E
G
--
K
--
F
R
-
R
--
I
--
P
Y
---
R
---
Y
S
D
E
L
N
E
I
I
T
R
M
L
-----
N
L
K
D
Y
H
R
P
S
V
E
E
-----
I
L
E
N
P
L
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
59.70
32%
-42
- C2 -
-
2UZT
1
KAPCA_BOVIN
A:
[26-277]
------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
R
I
G
----
R
F
S
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
----
T
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
D
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
59.57
33%
-38
- C2 -
-
2OJF
1
KAPCA_BOVIN
E:
[41-292]
------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
R
I
G
----
R
F
S
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
V
K
--
G
R
T
-----
W
T
L
C
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
56.24
32%
-53
- C2 -
-
4QML
2
STK24_HUMAN
A:
[29-287]
-------------------------------------------------------------------------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
-
E
-
D
-
E
I
E
D
-
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
--
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--
E
P
G
P
----
L
-
D
------
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-----
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
-
G
Q
L
--
T
D
T
-
Q
I
-
K
R
N
F
V
G
T
P
F
W
M
A
P
E
V
--
I
K
---
Q
S
-----
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
PP
H
S
--
E
L
H
P
M
K
--
V
L
F
L
I
----
P
K
--
N
--
N
P
-
P
T-
L
--
E
G
---
N
---
Y
S
K
P
L
K
E
F
V
E
A
C
L
-----
N
K
E
P
S
F
R
P
T
A
K
E
-----
L
L
K
H
K
F
I
L
R
N
A
-----
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
56.14
32%
-53
- C2 -
-
4QMO
3
STK24_HUMAN
A:
[29-287]
-------------------------------------------------------------------------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
-
E
-
D
-
E
I
E
D
-
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
--
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--
E
P
G
P
----
L
-
D
------
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-----
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
-
G
Q
L
--
T
D
T
-
Q
I
-
K
R
N
F
V
G
T
P
F
W
M
A
P
E
V
--
I
K
---
Q
S
-----
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
PP
H
S
--
E
L
H
P
M
K
--
V
L
F
L
I
----
P
K
--
N
--
N
P
-
P
T-
L
--
E
G
---
N
---
Y
S
K
P
L
K
E
F
V
E
A
C
L
-----
N
K
E
P
S
F
R
P
T
A
K
E
-----
L
L
K
H
K
F
I
L
R
N
A
-----
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
55.96
32%
-53
- C2 -
-
4U8Z
1
STK24_HUMAN
A:
[14-272]
-------------------------------------------------------------------------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
-
E
-
D
-
E
I
E
D
-
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
--
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--
E
P
G
P
----
L
-
D
------
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-----
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
-
G
Q
L
--
T
D
T
-
Q
I
-
K
R
N
F
V
G
T
P
F
W
M
A
P
E
V
--
I
K
---
Q
S
-----
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
PP
H
S
--
E
L
H
P
M
K
--
V
L
F
L
I
----
P
K
--
N
--
N
P
-
P
T-
L
--
E
G
---
N
---
Y
S
K
P
L
K
E
F
V
E
A
C
L
-----
N
K
E
P
S
F
R
P
T
A
K
E
-----
L
L
K
H
K
F
I
L
R
N
A
-----
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
55.87
32%
-53
- C2 -
-
4QMT
2
STK24_HUMAN
A:
[29-287]
-------------------------------------------------------------------------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
-
E
-
D
-
E
I
E
D
-
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
--
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--
E
P
G
P
----
L
-
D
------
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-----
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
-
G
Q
L
--
T
D
T
-
Q
I
-
K
R
N
F
V
G
T
P
F
W
M
A
P
E
V
--
I
K
---
Q
S
-----
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
PP
H
S
--
E
L
H
P
M
K
--
V
L
F
L
I
----
P
K
--
N
--
N
P
-
P
T-
L
--
E
G
---
N
---
Y
S
K
P
L
K
E
F
V
E
A
C
L
-----
N
K
E
P
S
F
R
P
T
A
K
E
-----
L
L
K
H
K
F
I
L
R
N
A
-----
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
55.75
32%
-51
- C2 -
-
4QMW
2
STK24_HUMAN
A:
[29-287]
-------------------------------------------------------------------------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
-
E
-
D
-
E
I
E
D
-
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
--
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--
E
P
G
P
----
L
-
D
------
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-----
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
-
G
Q
L
--
T
D
T
-
Q
I
-
K
R
N
F
V
G
T
P
F
W
M
A
P
E
V
--
I
K
---
Q
S
-----
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
PP
H
S
--
E
L
H
P
M
K
--
V
L
F
L
I
----
P
K
--
N
--
N
P
-
P
T-
L
--
E
G
---
N
---
Y
S
K
P
L
K
E
F
V
E
A
C
L
-----
N
K
E
P
S
F
R
P
T
A
K
E
-----
L
L
K
H
K
F
I
L
R
N
A
-----
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
55.71
32%
-54
- C2 -
-
4W8D
1
STK24_HUMAN
A:
[14-272]
-------------------------------------------------------------------------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
-
E
-
D
-
E
I
E
D
-
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
--
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--
E
P
G
P
----
L
-
D
------
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-----
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
-
G
Q
L
--
T
D
T
-
Q
I
-
K
R
N
F
V
G
T
P
F
W
M
A
P
E
V
--
I
K
---
Q
S
-----
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
PP
H
S
--
E
L
H
P
M
K
--
V
L
F
L
I
----
P
K
--
N
--
N
P
-
P
T-
L
--
E
G
---
N
---
Y
S
K
P
L
K
E
F
V
E
A
C
L
-----
N
K
E
P
S
F
R
P
T
A
K
E
-----
L
L
K
H
K
F
I
L
R
N
A
-----
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
55.69
32%
-41
- C2 -
-
5LCU
5
KAPCA_CRIGR
A:
[43-294]
------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
R
I
G
----
R
F
S
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
55.56
32%
-52
- C2 -
-
4W8E
1
STK24_HUMAN
A:
[14-272]
-------------------------------------------------------------------------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
-
E
-
D
-
E
I
E
D
-
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
--
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--
E
P
G
P
----
L
-
D
------
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-----
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
-
G
Q
L
--
T
D
T
-
Q
I
-
K
R
N
F
V
G
T
P
F
W
M
A
P
E
V
--
I
K
---
Q
S
-----
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
PP
H
S
--
E
L
H
P
M
K
--
V
L
F
L
I
----
P
K
--
N
--
N
P
-
P
T-
L
--
E
G
---
N
---
Y
S
K
P
L
K
E
F
V
E
A
C
L
-----
N
K
E
P
S
F
R
P
T
A
K
E
-----
L
L
K
H
K
F
I
L
R
N
A
-----
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
55.47
31%
-66
- C2 -
-
5UPK
1
?
B:
[81-329]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
55.45
32%
-27
- C2 -
-
4GV1
5
AKT1_HUMAN
A:
[7-288]
------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
-
K
D
E
V
A
H
-
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
--
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
------
V
F
S
------
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N----
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
-
K
E
G
--
I
K
D
G
A
T
-
M
K
F
C
-
G
T
P
E
Y
L
A
P
E
V
--
L
E
---
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
--
L
P
-
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
----
M
E
--
E
IR
F
P
-
R
--
T
-----------
L
G
P
E
A
K
S
L
L
S
G
L
L
-----
K
K
D
P
K
Q
R
L
G
G
G
S
EDAKE
I
M
Q
H
R
F
F
A
G
I
V
WQHVY
E
K
K
L
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
449
Blastp_CBE
55.04
31%
-66
- C2 -
-
5BMS
1
A:
[28-276]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
RL
K
--
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
54.82
31%
-67
- C2 -
-
5ZJW
10
A:
[28-276]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
54.80
32%
-50
- C2 -
-
3A7H
1
STK24_HUMAN
B:
[22-280]
-------------------------------------------------------------------------
E
L
F
T
K
L
E
K
I
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
I
I
D
L
E
E
-
A
-
E
-
D
-
E
I
E
D
-
I
Q
Q
E
I
T
V
L
S
Q
C
D
S
P
Y
V
T
K
Y
Y
G
S
Y
--
L
K
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
L
L
--
E
P
G
P
----
L
-
D
------
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
-----
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
H
G
E
V
K
L
A
D
F
G
V
A
-
G
Q
L
--
T
D
T
-
Q
I
-
K
R
N
F
V
G
T
P
F
W
M
A
P
E
V
--
I
K
---
Q
S
-----
A
Y
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
PP
H
S
--
E
L
H
P
M
K
--
V
L
F
L
I
----
P
K
--
N
--
N
P
-
P
T-
L
--
E
G
---
N
---
Y
S
K
P
L
K
E
F
V
E
A
C
L
-----
N
K
E
P
S
F
R
P
T
A
K
E
-----
L
L
K
H
K
F
I
L
R
N
A
-----
K
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
54.75
31%
-64
- C2 -
-
5VEF
1
?
A:
[54-302]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
54.73
32%
-29
- C2 -
-
4EKK
1
AKT1_HUMAN
A:
[8-299]
------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
-
K
D
E
V
A
H
-
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
--
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
------
V
F
S
------
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N----
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
-
K
E
G
--
I
K
D
G
A
T
-
M
K
F
C
-
G
T
P
E
Y
L
A
P
E
V
--
L
E
---
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
--
L
P
-
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
----
M
E
--
E
IR
F
P
-
R
--
T
-----------
L
G
P
E
A
K
S
L
L
S
G
L
L
-----
K
K
D
P
K
Q
R
L
G
G
G
S
EDAKE
I
M
Q
H
R
F
F
A
G
I
V
WQHVY
E
K
K
L
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
54.61
31%
-70
- C2 -
-
4NJD
1
A:
[31-279]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
54.58
31%
-61
- C2 -
-
5XVG
7
A:
[28-276]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
54.54
31%
-68
- C2 -
-
4FIF
1
PAK4_HUMAN
B:
[81-329]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
54.51
31%
-66
- C2 -
-
5XVA
4
PAK4_HUMAN
A:
[28-276]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
54.49
31%
-66
- C2 -
-
2J0I
4
A:
[38-286]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
54.45
32%
-38
- C2 -
-
5LCR
6
KAPCA_CRIGR
A:
[43-294]
------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
R
I
G
----
R
F
S
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
54.42
32%
-34
- C2 -
-
5M0U
8
KAPCA_CRIGR
A:
[43-294]
------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
----
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
--
R
R
I
G
----
R
F
S
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
54.27
31%
-66
- C2 -
-
5VED
1
PAK4_HUMAN
A:
[54-302]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
54.22
31%
-65
- C2 -
-
2X4Z
3
A:
[31-279]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
54.00
31%
-66
- C2 -
-
5I0B
1
PAK4_HUMAN
A:
[31-279]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
53.79
31%
-62
- C2 -
-
4JDI
1
PAK4_HUMAN
A:
[81-329]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
53.60
32%
-61
- C2 -
-
6HXF
4
STK10_HUMAN
D:
[27-294]
---------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
--
S
-
E
-
E
-
E
L
E
D
-
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
----
G
L
T
------
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-----
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
K
L
Q
K
R
D
F
I
G
T
P
Y
W
M
A
P
E
V
VM
C
E
---
M
K
-----
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
--
P
P
-
H
H
E
L
N
P
M
R
V
L
L
K
-
I
----
A
K
--
S
--
D
P
-
P
--
T
--
L
L
TPS
K
---
W
S
V
E
F
R
D
F
L
K
I
A
L
-----
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
53.47
31%
-58
- C2 -
-
2Q0N
7
A:
[36-284]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
53.46
32%
-26
- C2 -
-
3MV5
1
AKT1_HUMAN
A:
[9-303]
------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
-
K
D
E
V
A
H
-
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
--
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
------
V
F
S
------
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N----
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
-
K
E
G
--
I
K
D
G
A
T
-
M
K
F
C
-
G
T
P
E
Y
L
A
P
E
V
--
L
E
---
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
--
L
P
-
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
----
M
E
--
E
IR
F
P
-
R
--
T
-----------
L
G
P
E
A
K
S
L
L
S
G
L
L
-----
K
K
D
P
K
Q
R
L
G
G
G
S
EDAKE
I
M
Q
H
R
F
F
A
G
I
V
WQHVY
E
K
K
L
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
53.35
32%
-26
- C2 -
-
3CQU
1
AKT1_HUMAN
A:
[9-301]
------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
K
K
E
V
I
V
-
A
-
K
D
E
V
A
H
-
T
L
T
E
N
R
V
L
Q
N
S
R
H
P
F
L
T
A
L
K
Y
S
F
--
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
------
V
F
S
------
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N----
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
-
K
E
G
--
I
K
D
G
A
T
-
M
K
F
C
-
G
T
P
E
Y
L
A
P
E
V
--
L
E
---
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
--
L
P
-
F
Y
N
Q
D
H
E
K
L
F
E
L
I
L
----
M
E
--
E
IR
F
P
-
R
--
T
-----------
L
G
P
E
A
K
S
L
L
S
G
L
L
-----
K
K
D
P
K
Q
R
L
G
G
G
S
EDAKE
I
M
Q
H
R
F
F
A
G
I
V
WQHVY
E
K
K
L
S
P
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
53.24
31%
-65
- C2 -
-
5XVF
1
A:
[28-276]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
RL
K
--
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
52.91
31%
-60
- C2 -
-
4APP
2
A:
[31-279]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
52.81
31%
-65
- C2 -
-
2CDZ
1
A:
[38-286]
--------------------------------------------------------------------------------
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
K
M
D
L
R
K
---
Q
-
Q
-
R
R
E
L
-
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
--
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
T
R
-------
M
N
------
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
-----
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
G
R
V
K
L
S
D
F
G
F
C
-
A
Q
V
--
S
K
E
V
P
--
R
R
K
L
V
G
T
P
Y
W
M
A
P
E
L
--
I
S
---
R
L
-----
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
--
P
P
Y
F
N
E
P
P
L
K
--
A
M
K
M
I
----
R
D
--
N
--
L
P
-
P
--
R
LK
N
L
---
H
K--
V
S
P
S
L
K
G
F
L
D
R
L
L
-----
V
R
D
P
A
Q
R
A
T
A
A
E
-----
L
L
K
H
P
F
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
51.78
32%
-49
- C2 -
-
6HXF
5
STK10_HUMAN
B:
[27-294]
---------------------------------------------------------------------------------
L
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
V
I
E
T
K
--
S
-
E
-
E
-
E
L
E
D
-
Y
I
V
E
I
E
I
L
A
T
C
D
H
P
Y
I
V
K
L
L
G
A
Y
--
Y
H
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
-
D
A
I
M
L
E
L
D
R
----
G
L
T
------
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
-----
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
E
G
D
I
R
L
A
D
F
G
V
S
------
A
K
N
L
K
L
Q
K
R
D
F
I
G
T
P
Y
W
M
A
P
E
V
VM
C
E
---
M
K
DT---
P
Y
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
--
P
P
-
H
H
E
L
N
P
M
R
V
L
L
K
-
I
----
A
K
--
S
--
D
P
-
P
--
T
--
L
L
TPS
K
---
W
S
V
E
F
R
D
F
L
K
I
A
L
-----
D
K
N
P
E
T
R
P
S
A
A
Q
-----
L
L
E
H
P
F
V
S
S
I
T
-----
S
N
K
A
L
R
E
L
V
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
50.67
32%
-45
- C2 -
-
1O6K
1
AKT2_HUMAN
A:
[4-263]
------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
-
K
D
E
V
A
H
-
T
V
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
--
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
------
V
F
T
------
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
-----
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
-
K
E
G
--
I
S
D
G
A
T
-
M
K
F
C
-
G
T
P
E
Y
L
A
P
E
V
--
L
E
---
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
--
L
P
-
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
----
M
E
EI
R
--
F
P
-
R
--
T
-----------
L
S
P
E
A
K
S
L
L
A
G
L
L
-----
K
K
D
P
K
Q
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
50.50
32%
-42
- C2 -
-
1O6L
1
AKT2_HUMAN
A:
[4-267]
------------------------------------------------------------------------
M
N
D
F
D
Y
L
K
L
L
G
K
G
T
F
G
K
V
I
L
V
R
E
K
A
T
G
R
Y
Y
A
M
K
I
L
R
K
E
V
I
I
-
A
-
K
D
E
V
A
H
-
T
V
T
E
S
R
V
L
Q
N
T
R
H
P
F
L
T
A
L
K
Y
A
F
--
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
R
------
V
F
T
------
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
R
D
-----
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
G
H
I
K
I
T
D
F
G
L
C
-
K
E
G
--
I
S
D
G
A
T
-
M
K
F
C
-
G
T
P
E
Y
L
A
P
E
V
--
L
E
---
D
N
-----
D
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
--
L
P
-
F
Y
N
Q
D
H
E
R
L
F
E
L
I
L
----
M
E
--
E
IR
F
P
-
R
--
T
-----------
L
S
P
E
A
K
S
L
L
A
G
L
L
-----
K
K
D
P
K
Q
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
46.54
32%
-3
- C2 -
-
2QCS
5
KAPCA_MOUSE
A:
[40-291]
------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
---
R
R
I
----
G
R
F
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
46.13
32%
-6
- C2 -
-
1L3R
3
KAPCA_MOUSE
E:
[40-291]
------------------------------------------------------------------------
L
D
Q
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
---
R
R
I
----
G
R
F
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
45.99
32%
-4
- C2 -
-
6EMA
2
KAPCA_CRIGR
A:
[43-294]
------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
---
R
R
I
----
G
R
F
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
45.64
32%
-6
- C2 -
-
3ZO1
7
KAPCA_BOVIN
A:
[41-292]
------------------------------------------------------------------------
L
D
Q
F
E
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
---
R
R
I
----
G
R
F
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
45.53
32%
-4
- C2 -
-
5N3G
4
KAPCA_CRIGR
A:
[43-294]
------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
---
R
R
I
----
G
R
F
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
45.23
32%
-2
- C2 -
-
6ESA
4
KAPCA_CRIGR
A:
[43-294]
------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
---
R
R
I
----
G
R
F
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
45.10
32%
-1
- C2 -
-
6EM7
4
KAPCA_CRIGR
A:
[43-294]
------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
---
R
R
I
----
G
R
F
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
44.66
32%
-7
- C2 -
-
5OUC
2
KAPCA_CRIGR
A:
[43-294]
------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
---
R
R
I
----
G
R
F
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
44.19
32%
-8
- C2 -
-
5OT3
3
KAPCA_CRIGR
A:
[43-294]
------------------------------------------------------------------------
L
D
H
F
D
R
I
K
T
L
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
K
Q
K
V
V
-
K
L
K
-
Q
I
E
H
-
T
L
N
E
K
R
I
L
Q
A
V
N
F
P
F
L
V
K
L
E
F
S
F
--
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
---
R
R
I
----
G
R
F
------
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
-----
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
G
Y
I
Q
V
T
D
F
G
F
A
-
K
R
V
--
K
G
R
T
W
L
-
C
----
G
T
P
E
Y
L
A
P
E
I
--
I
L
---
S
K
-----
G
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
--
P
P
-
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
V
----
S
G
--
K
VR
F
P
-
S
----------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
QVDLT
K
R
F
G
N
L
K
N
G
V
N
D
-----
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
43.12
31%
-23
- C2 -
-
2JFL
6
SLK_HUMAN
A:
[42-311]
------------------------------------------------------------------------------
I
G
E
L
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
V
I
D
T
K
--
S
-
E
-
E
-
E
L
E
D
-
Y
M
V
E
I
D
I
L
A
S
C
D
H
P
N
I
V
K
L
L
D
A
F
--
Y
Y
E
N
N
L
W
I
L
I
E
F
C
A
G
G
-------
A
V
D
A
V
----
M
L
E
LERPLT
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
-----
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
D
G
D
I
K
L
A
D
F
G
V
S
--
A
K
--
N
T
R
I
Q
--
R
R
D
F
I
G
T
P
Y
W
M
A
P
E
V
VM
C
E
TSK
D
R
-----
P
Y
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
--
P
P
-
H
H
E
L
N
P
M
R
V
L
L
K
-
I
----
A
K
--
S
--
E
P
-
P
--
T
--
L
A
---
Q
PSR
W
S
S
N
F
K
D
F
L
K
K
C
L
-----
E
K
N
V
D
A
R
W
T
T
S
Q
-----
L
L
Q
H
P
F
V
T
V
D
S
-----
N
K
P
I
R
-
E
L
I
A
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------