@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PAK7_HUMAN: (2020-09-18 )
MFGKKKKKIEISGPSNFEHRVHTGFDPQEQKFTGLPQQWHSLLADTANRPKPMVDPSCITPIQLAPMKTIVRGNKPCKETSINGLLEDFDNISVTRSNSLRKESPPTPDQGASSHGPGHAEENGFITFSQYSSESDTTADYTTEKYREKSLYGDDLDPYYRGSHAAKQNGHVMKMKHGEAYYSEVKPLKSDFARFSADYHSHLDSLSKPSEYSDLKWEYQRASSSSPLDYSFQFTPSRTAGTSGCSKESLAYSESEWGPSLDDYDRRPKSSYLNQTSPQPTMRQRSRSGSGLQEPMMPFGASAFKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRAQMVLSPPLSGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGYHKATLYHHPSLQSSSQYISTASYLSSLSLSSSTYPPPSWGSSSDQQPSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH
Atome Classification :
(149 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450...---....460.......470......---.480--....-....490---...-......500........510..------.------....520.......530.-..-.--.--.-.---------540--........550.......560.......570......---.580.........590.......600.......610...-----.-----..---.620........630.......640.......650...-...--.----660-----..---...--....670.......680.......690.......-700.......710.......
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MFGK
K
K
K
K
I
E
ISGPSNFEHRVHTGFDP
Q
E
Q
K
FTGL
P
Q
Q
W
H
S
L
L
A
DTANRPKPMVDPSCIT
P
I
QLA
P
M
K
T
I
VRGNKPCKE
T
S
I
N
G
L
L
E
DFDN
I
S
V
TRSNSLRKESPPTPDQGASSHGPGHAEEN
G
F
I
T
F
SQYSSESDTTADY
T
T
E
K
Y
R
E
KSLYGDDL
D
P
Y
YRGSHAAKQNG
H
V
M
K
M
KHG
E
A
Y
Y
S
E
V
K
P
L
K
S
D
F
A
R
F
S
A
D
Y
H
S
H
L
D
SLSKPSEYSD
L
K
W
E
Y
QRASSSSP
L
D
Y
S
F
QFTPSRTAGTSGCSKESLAYSESEWGPSL
D
D
YDRRP
K
S
SYLNQTSPQ
P
T
M
R
Q
RSRSGSGLQEPMMPFGA
S
A
FKTHPQGHSYNSYTYPRLSEPTMCIPKVDYDRA
Q
M
V
LSPPLSGSDTYPRGPAKLPQSQSKSGYSSSSHQYPSGY
H
K
A
T
L
Y
HHPSLQSSS
Q
Y
I
S
T
A
S
Y
L
S
S
LSLSSSTYPPPSWGSSSDQQPSRV
S
H
E
Q
F
R
A
A
L
Q
L
V
VSPG
D
P
R
E
Y
L
A
N
F
I
KI---GEGS
T
G
I
V
C
I
ATEKHTG
K
Q
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N-
E
V
V
I
M
R
DY-HHD
N
V
V
D
M
Y
S
S
Y
L------V------G
D
E
L
W
V
V
M
E
F
LEGGA
L
T
D
-
I
V
-
T
--H--T-R---------M
N
---
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
HNQG
V
I
H
R
DIKSD
S
I
L
LTS---DG--
R
I
K
LSDF
G
F
C
A
Q
V
S
K
EVPKRKSLVGTPYWM
A
P
E
V
I
-----
S
-----RL---PY-GTE
V
D
I
W
S
L
G
I
M
V
I
E
MIDGEPPYFNEP
P
L
Q
A
M
R
R
I
-
R
D
S--L----
P
-------
P
R
---
V
K
D
--
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
LVREPSQ
R
A
T
A
Q
E
L
LGH
P
F
-LKLAG
P
P
S
C
I
V
P
L
M
R
Q
YRHH
1
PsiBlast_PDB
97.90
98%
-137
- C2 -
-
2F57
1
PAK5_HUMAN
A:
[20-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
H
H
D
N
V
V
D
M
Y
S
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
---
D
G
--
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
L
---
P
Y
-
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
P
P
L
Q
A
M
R
R
I
-
R
D
S
--
L
----
P
-------
P
R
---
V
K
D
--
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
-
L
K
L
A
G
P
P
S
C
I
V
P
L
M
R
Q
----
509
HHSearch
97.71
100%
-140
- C2 -
-
2F57
1
PAK5_HUMAN
A:
[24-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
H
H
D
N
V
V
D
M
Y
S
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
---
D
G
--
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
L
---
P
Y
-
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
P
P
L
Q
A
M
R
R
I
-
R
D
S
--
L
----
P
-------
P
R
---
V
K
D
--
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
-
L
K
L
A
G
P
P
S
C
I
V
P
L
M
R
Q
----
21
Blastp_CBE
97.42
99%
-129
- C2 -
-
2F57
1
B:
[20-316]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
S
M
S
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
S
P
G
D
P
R
E
Y
L
A
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
E
K
H
T
G
K
Q
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
H
H
D
N
V
V
D
M
Y
S
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
T
V
C
L
S
V
L
R
A
L
S
Y
L
H
N
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
S
---
D
G
--
R
I
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
L
---
P
Y
-
G
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
I
D
G
E
P
P
Y
F
N
E
P
P
L
Q
A
M
R
R
I
-
R
D
S
--
L
----
P
-------
P
R
---
V
K
D
--
L
H
K
V
S
S
V
L
R
G
F
L
D
L
M
L
V
R
E
P
S
Q
R
A
T
A
Q
E
L
L
G
H
P
F
-
L
K
L
A
G
P
P
S
C
I
V
P
L
M
R
Q
Y
R
H
-
34
Blastp_CBE
92.84
85%
-130
- C2 -
-
4O0X
1
?
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
4
PsiBlast_PDB
92.76
82%
-133
- C2 -
-
4XBU
-
PAK4_HUMAN
A:
[297-589]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
3
PsiBlast_PDB
92.70
83%
-131
- C2 -
-
2J0I
4
PAK4_HUMAN
A:
[12-301]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
29
Blastp_CBE
92.51
85%
-129
- C2 -
-
5ZJW
10
PAK4_HUMAN
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
510
HHSearch
92.45
85%
-131
- C2 -
-
5XVF
1
PAK4_HUMAN
A:
[2-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
---
26
Blastp_CBE
92.30
84%
-133
- C2 -
-
4NJD
1
PAK4_HUMAN
A:
[4-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
24
Blastp_CBE
92.26
84%
-122
- C2 -
-
4FIF
1
PAK4_HUMAN
B:
[52-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
23
Blastp_CBE
92.24
84%
-122
- C2 -
-
4FIG
1
?
B:
[53-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
30
Blastp_CBE
92.23
85%
-123
- C2 -
-
5XVG
9
PAK4_HUMAN
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
9
PsiBlast_PDB
92.20
83%
-127
- C2 -
-
5VEF
1
?
A:
[28-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
35
Blastp_CBE
92.06
85%
-129
- C2 -
-
4O0V
1
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
28
Blastp_CBE
92.06
84%
-126
- C2 -
-
2X4Z
3
A:
[4-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
27
Blastp_CBE
91.91
84%
-123
- C2 -
-
4APP
2
A:
[4-294]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
11
PsiBlast_PDB
91.91
83%
-124
- C2 -
-
4FIF
1
PAK4_HUMAN
A:
[51-344]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
16
PsiBlast_PDB
91.90
83%
-126
- C2 -
-
4JDH
-
?
A:
[55-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
14
PsiBlast_PDB
91.89
83%
-128
- C2 -
-
4FII
-
PAK4_HUMAN
A:
[54-344]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
2
PsiBlast_PDB
91.89
83%
-130
- C2 -
-
2CDZ
1
PAK4_HUMAN
A:
[11-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
--
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
37
Blastp_CBE
91.84
85%
-132
- C2 -
-
5XVF
1
PAK4_HUMAN
A:
[2-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
----
17
PsiBlast_PDB
91.77
83%
-126
- C2 -
-
4JDI
1
PAK4_HUMAN
A:
[55-344]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
10
PsiBlast_PDB
91.67
83%
-126
- C2 -
-
2Q0N
7
PAK4_HUMAN
A:
[8-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
32
Blastp_CBE
91.63
85%
-126
- C2 -
-
5BMS
1
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
31
Blastp_CBE
91.54
85%
-126
- C2 -
-
5XVA
5
PAK4_HUMAN
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
12
PsiBlast_PDB
91.42
83%
-125
- C2 -
-
4FIG
1
?
A:
[53-344]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
7
PsiBlast_PDB
91.26
83%
-126
- C2 -
-
5VED
1
PAK4_HUMAN
A:
[28-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
33
Blastp_CBE
91.25
85%
-125
- C2 -
-
4O0Y
1
A:
[2-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
18
PsiBlast_PDB
90.68
83%
-125
- C2 -
-
5UPK
1
?
B:
[55-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
---
25
Blastp_CBE
90.28
84%
-130
- C2 -
-
5I0B
1
PAK4_HUMAN
A:
[6-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
8
PsiBlast_PDB
89.88
83%
-130
- C2 -
-
5VEE
1
PAK4_HUMAN
A:
[28-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
513
HHSearch
89.10
76%
-128
- C2 -
-
4KS7
2
A:
[5-290]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
---
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
---
M
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
------
V
------
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
-
I
V
-
S
--
Q
--
V
-
R
---------
L
N
---
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
S
---
L
Y
-
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
-
R
D
S
--
P
----
P
-------
P
K
---
L
K
N
--
S
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
L
Q
T
G
L
P
E
C
L
V
P
L
I
Q
-----
41
Blastp_CBE
89.02
76%
-128
- C2 -
-
4KS7
2
A:
[4-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
---
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
---
M
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
------
V
------
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
-
I
V
-
S
--
Q
--
V
-
R
---------
L
N
---
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
S
---
L
Y
-
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
-
R
D
S
--
P
----
P
-------
P
K
---
L
K
N
--
S
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
L
Q
T
G
L
P
E
C
L
V
P
L
I
Q
-----
40
Blastp_CBE
88.44
76%
-130
- C2 -
-
4KS8
1
A:
[3-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
H
E
Q
F
K
A
A
L
R
M
V
V
D
Q
G
D
P
R
L
L
L
D
S
Y
V
K
I
---
G
E
G
S
T
G
I
V
C
L
A
R
E
K
H
S
G
R
Q
V
A
V
K
---
M
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
F
N
V
V
E
M
Y
K
S
Y
L
------
V
------
G
E
E
L
W
V
L
M
E
F
L
Q
G
G
A
L
T
D
-
I
V
-
S
--
Q
--
V
-
R
---------
L
N
---
E
E
Q
I
A
T
V
C
E
A
V
L
Q
A
L
A
Y
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
L
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
I
S
K
D
V
P
K
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
V
I
-----
S
-----
R
S
---
L
Y
-
A
T
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
S
D
S
P
V
Q
A
M
K
R
L
-
R
D
S
--
P
----
P
-------
P
K
---
L
K
N
--
S
H
K
V
S
P
V
L
R
D
F
L
E
R
M
L
V
R
D
P
Q
E
R
A
T
A
Q
E
L
L
D
H
P
F
-
L
L
Q
T
G
L
P
E
C
L
V
P
L
I
------
507
HHSearch
86.30
84%
-119
- C2 -
-
4FIE
1
PAK4_HUMAN
B:
[145-422]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
S
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
T
-
67
Blastp_CBE
81.15
52%
-135
- C2 -
-
5DEY
1
PAK1_HUMAN
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
69
Blastp_CBE
80.92
52%
-132
- C2 -
-
5DEW
1
PAK1_HUMAN
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
63
Blastp_CBE
80.88
52%
-128
- C2 -
-
4O0R
1
PAK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
81
Blastp_CBE
80.75
53%
-132
- C2 -
-
5KBQ
1
PAK1_HUMAN
A:
[4-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
58
Blastp_CBE
80.70
52%
-132
- C2 -
-
4ZY4
2
PAK1_HUMAN
B:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
-
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
78
Blastp_CBE
80.49
53%
-118
- C2 -
-
6FD3
3
PAK3_HUMAN
A:
[2-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
T
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
L
D
I
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
D
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
-
S
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
V
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
R
L
S
A
V
F
R
D
F
L
N
R
C
L
E
M
D
V
D
R
R
G
S
A
K
E
L
L
Q
H
P
F
-
L
K
L
D
K
P
L
S
S
L
T
P
L
I
------
68
Blastp_CBE
80.41
52%
-135
- C2 -
-
5DEW
1
PAK1_HUMAN
B:
[7-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
-------
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
56
Blastp_CBE
80.33
52%
-135
- C2 -
-
4ZY5
2
PAK1_HUMAN
B:
[8-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
-
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
52
Blastp_CBE
79.36
52%
-135
- C2 -
-
6B16
1
PAK1_HUMAN
B:
[8-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
-------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
522
HHSearch
79.30
53%
-124
- C2 -
-
5KBQ
1
PAK1_HUMAN
A:
[9-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
A
A
----
62
Blastp_CBE
79.14
52%
-121
- C2 -
-
4O0T
1
PAK1_HUMAN
A:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
66
Blastp_CBE
79.03
52%
-131
- C2 -
-
5DEY
1
PAK1_HUMAN
B:
[7-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
-------
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
54
Blastp_CBE
78.24
52%
-133
- C2 -
-
4ZY6
1
PAK1_HUMAN
B:
[8-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
--------
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
59
Blastp_CBE
78.14
52%
-125
- C2 -
-
4ZY4
1
PAK1_HUMAN
A:
[2-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----------
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
65
Blastp_CBE
78.08
52%
-134
- C2 -
-
3Q4Z
1
PAK1_HUMAN
A:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
I
I
V
S
V
G
D
P
K
-----
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
R
---
Q
M
N
---
L
------
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
53
Blastp_CBE
77.88
52%
-130
- C2 -
-
6B16
1
PAK1_HUMAN
A:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----------
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
--------------
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
517
HHSearch
77.01
53%
-112
- C2 -
-
6FD3
3
PAK3_HUMAN
A:
[17-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
L
D
I
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
D
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
-
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
V
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
R
L
S
A
V
F
R
D
F
L
N
R
C
L
E
M
D
V
D
R
R
G
S
A
K
E
L
L
Q
H
P
F
-
L
K
L
D
K
P
L
S
S
L
T
P
L
I
I
-----
57
Blastp_CBE
76.92
52%
-124
- C2 -
-
4ZY5
1
PAK1_HUMAN
A:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
-
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
-----------
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
---------------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
61
Blastp_CBE
76.91
52%
-136
- C2 -
-
5IME
1
PAK1_HUMAN
A:
[3-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
-------
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
----
Q
E
V
A
I
K
---
Q
M
N
---
L
------
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
60
Blastp_CBE
76.79
52%
-126
- C2 -
-
5IME
1
?
B:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
--------
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
--------
E
Q
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
45
Blastp_CBE
76.53
53%
-137
- C2 -
-
4ZJJ
1
PAK1_HUMAN
A:
[3-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
-----
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
55
Blastp_CBE
76.18
52%
-129
- C2 -
-
4ZY6
1
PAK1_HUMAN
A:
[4-287]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
------------
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
44
Blastp_CBE
76.02
53%
-140
- C2 -
-
4ZJJ
1
PAK1_HUMAN
B:
[5-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
------
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
-------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
49
Blastp_CBE
75.84
53%
-138
- C2 -
-
4ZJI
1
PAK1_HUMAN
A:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
------
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
72
Blastp_CBE
75.74
53%
-135
- C2 -
-
4ZLO
2
PAK1_HUMAN
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
--
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---------
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
--------
Q
S
K
R
-
S
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
48
Blastp_CBE
75.67
53%
-138
- C2 -
-
4ZJI
1
PAK1_HUMAN
B:
[8-288]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
------
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
------
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
71
Blastp_CBE
74.98
52%
-140
- C2 -
-
4P90
1
PAK1_HUMAN
A:
[2-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
------
E
V
A
I
K
---
Q
M
-----------
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
---------------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
-----
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
47
Blastp_CBE
74.75
53%
-129
- C2 -
-
4ZJI
1
?
C:
[4-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
-
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---------
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
-----
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
76
Blastp_CBE
73.93
53%
-95
- C2 -
-
3FXZ
1
?
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
-
S
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
46
Blastp_CBE
73.88
53%
-126
- C2 -
-
4ZJI
1
?
D:
[7-288]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---------
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
-
A
Q
I
T
---
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
77
Blastp_CBE
73.58
53%
-90
- C2 -
-
4EQC
1
PAK1_HUMAN
A:
[5-290]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
-
S
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
80
Blastp_CBE
73.44
53%
-142
- C2 -
-
5KBR
1
PAK1_HUMAN
A:
[4-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
-------
E
V
A
I
K
---
Q
-------------
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
------------------
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
-------
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
73
Blastp_CBE
73.37
53%
-92
- C2 -
-
5DFP
2
PAK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
-
S
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
75
Blastp_CBE
72.94
53%
-94
- C2 -
-
3FY0
1
PAK1_HUMAN
A:
[1-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
-
S
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
42
Blastp_CBE
72.47
53%
-142
- C2 -
-
4ZJJ
1
PAK1_HUMAN
D:
[6-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
L
E
K
L
R
S
I
V
S
V
---
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
----
E
V
A
I
K
---
Q
M
N
---
L
----
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
--------------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
----
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
70
Blastp_CBE
72.18
52%
-139
- C2 -
-
4P90
1
PAK1_HUMAN
B:
[9-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
----
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
---
L
---------------
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
-----------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
82
Blastp_CBE
71.59
52%
-89
- C2 -
-
3Q53
1
PAK1_HUMAN
A:
[3-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
R
---
Q
M
N
---
L
Q
Q
Q
-
P
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
-
S
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
I
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
79
Blastp_CBE
71.42
53%
-138
- C2 -
-
5KBR
1
PAK1_HUMAN
B:
[4-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
--------
G
T
V
Y
T
A
M
D
V
A
T
G
Q
E
V
A
I
K
---
Q
M
N
----------------------
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
N
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
-----------
S
K
R
S
E
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
-----
R
K
---
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
D
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
43
Blastp_CBE
71.25
53%
-133
- C2 -
-
4ZJJ
1
PAK1_HUMAN
C:
[5-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
I
L
E
K
L
R
S
I
V
S
V
G
D
P
K
K
K
Y
T
R
F
E
K
I
---
G
Q
G
A
S
G
T
V
Y
T
A
M
D
V
A
--
Q
E
V
A
I
K
---
Q
M
N
---
L
Q
----
K
K
E
L
-----
I
I
N
-
E
I
L
V
M
R
E
N
-
K
N
P
N
I
V
N
Y
L
D
S
Y
L
------
V
--------
E
L
W
V
V
M
E
Y
L
A
G
G
S
L
T
D
-
V
V
-
T
--
E
--
T
-
C
---------
M
D
---
E
G
Q
I
A
A
V
C
R
E
C
L
Q
A
L
E
F
L
H
S
N
Q
V
I
H
R
D
I
K
S
D
N
I
L
L
G
M
---
D
G
--
S
V
K
L
T
D
F
G
-------
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
V
V
-----
T
----------
A
Y
-
G
P
K
V
D
I
W
S
L
G
I
M
A
I
E
M
I
E
G
E
P
P
Y
L
N
E
N
P
L
R
A
L
Y
L
I
-
A
T
N
--
G
----
T
-------
P
E
---
L
Q
N
--
P
E
K
L
S
A
I
F
R
D
F
L
N
R
C
L
E
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Q
F
-
L
K
I
A
K
P
L
S
S
L
T
P
L
I
------
5
PsiBlast_PDB
68.10
83%
-40
- C2 -
-
4FIE
1
PAK4_HUMAN
A:
[46-421]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
R
E
P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
K
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
181
Blastp_CBE
62.28
37%
-17
- C2 -
-
6BDN
1
TAOK3_HUMAN
A:
[23-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
E
L
F
I
G
L
H
E
I
---
G
H
G
S
F
G
A
V
Y
F
A
T
N
A
H
T
S
E
V
V
A
I
K
---
K
M
S
---
Y
S
G
K
-
Q
T
H
E
K
WQD--
I
L
K
-
E
V
K
F
L
R
Q
L
-
K
H
P
N
T
I
E
Y
K
G
C
Y
L
------
K
------
E
H
T
A
W
L
V
M
E
Y
C
L
G
S
A
S
D
L
-
L
E
-
V
--
H
--
K
-
K
P--------
L
Q
---
E
V
E
I
A
A
I
T
H
G
A
L
H
G
L
A
Y
L
H
S
H
A
L
I
H
R
D
I
K
A
G
N
I
L
L
T
E
---
P
G
--
Q
V
K
L
A
D
F
G
S
A
S
M
A
S
P
A
----
N
S
F
V
G
T
P
Y
W
M
A
P
E
V
I
-----
L
-----
A
M
DEG
Q
Y
-
D
G
K
V
D
I
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
-
A
Q
N
--
D
----
S
-------
P
T
---
L
Q
S
---
N
E
W
T
D
S
F
R
R
F
V
D
Y
C
L
Q
K
I
P
Q
E
R
P
T
S
A
E
L
L
R
H
D
F
-
V
R
R
D
R
P
L
R
V
L
I
D
L
I
Q
R
T
K
--
518
HHSearch
62.13
40%
-59
- C2 -
-
5J5T
1
M4K3_HUMAN
A:
[5-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
L
I
Q
R
I
---
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
---
V
I
K
---
L
E
P
G
-
E
D
F
A
V
-----
V
Q
Q
-
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
------
R
------
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
-
I
Y
-
H
--
V
T-
G
-
P
---------
L
S
---
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
---
N
G
--
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
-----
A
VER--
K
G
---
G
Y
-
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
M
-
T
K
S
NF
Q
----
P
-------
P
K
---
L
K
D
--
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
-
V
T
Q
H
L
---------------
92
Blastp_CBE
62.05
39%
-14
- C2 -
-
4O27
1
STK24_HUMAN
B:
[2-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
E
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
--
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
22
Blastp_CBE
61.31
84%
-11
- C2 -
-
4FIE
1
PAK4_HUMAN
B:
[46-421]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
R
E
P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
-
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
90
Blastp_CBE
60.88
40%
-46
- C2 -
-
5DH3
1
STK3_HUMAN
A:
[25-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
E
V
F
D
V
L
E
K
L
---
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
E
S
G
Q
V
V
A
I
K
---
Q
V
P
---
V
E
S
D
-
L
Q
E
-------
I
I
K
-
E
I
S
I
M
Q
Q
C
-
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
------
K
------
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
-
I
I
-
R
LR
N
--
K
-
T
---------
L
I
---
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
D
I
K
A
G
N
I
L
L
N
T
---
E
G
--
H
A
K
L
A
D
F
G
V
A
G
Q
L
T
-
D
M
A
K
R
-
N
V
I
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
E
I
---
G
Y
-
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
-
P
T
N
--
P
----
P
-------
P
T
---
F
R
K
--
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
-
I
K
N
A
K
P
V
S
I
L
R
D
L
I
T
E
----
93
Blastp_CBE
60.86
40%
-57
- C2 -
-
5J5T
1
M4K3_HUMAN
A:
[11-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
---
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
---
V
I
K
---
L
E
P
G
-
E
D
F
A
V
-----
V
Q
Q
-
E
I
I
M
M
K
D
C
-
K
H
P
N
I
V
A
Y
F
G
S
Y
L
------
R
------
R
D
K
L
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
-
I
Y
-
H
--
V
--
T
-
G
P--------
L
S
---
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
S
K
G
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
---
N
G
--
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
-----
A
VER--
K
G
---
G
Y
-
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
A
L
F
L
M
-
T
K
S
NF
Q
----
P
-------
P
K
---
L
K
D
--
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
-
V
-------------------
134
Blastp_CBE
60.75
38%
-50
- C2 -
-
4FZA
3
STK26_HUMAN
B:
[4-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
R
--
A
--
G
-
P
---------
F
D
---
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
--
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
----
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
-------------------
102
Blastp_CBE
59.73
39%
-18
- C2 -
-
3A7I
1
STK24_HUMAN
A:
[18-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
89
Blastp_CBE
59.44
40%
-44
- C2 -
-
5DH3
1
STK3_HUMAN
B:
[25-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
E
V
F
D
V
L
E
K
L
---
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
E
S
G
Q
V
V
A
I
K
---
Q
V
P
---
V
E
S
D
-
L
Q
E
-------
I
I
K
-
E
I
S
I
M
Q
Q
C
-
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
------
K
------
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
-
I
I
-
R
LR
N
--
K
-
T
---------
L
I
---
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
D
I
K
A
G
N
I
L
L
N
T
---
E
G
--
H
A
K
L
A
D
F
G
V
A
G
Q
L
T
-
D
M
A
K
R
-
N
V
I
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
E
I
---
G
Y
-
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
-
P
T
N
--
P
----
P
-------
P
T
---
F
R
K
--
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
-
I
K
N
A
K
P
V
S
I
L
R
D
L
I
T
E
----
129
Blastp_CBE
59.29
39%
-18
- C2 -
-
4W8D
1
STK24_HUMAN
A:
[10-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
--
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
132
Blastp_CBE
59.26
38%
-51
- C2 -
-
4FZF
1
?
B:
[4-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
R
I
---
G
K
G
--
G
E
V
F
K
G
I
D
N
R
T
Q
Q
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
S
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
G
S
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
R
--
A
--
G
-
P
---------
F
D
---
E
F
Q
I
A
T
M
L
K
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
Q
G
--
D
V
K
L
A
A
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
N
T
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
K
G
E
P
P
N
S
D
M
H
P
M
R
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
----
V
G
D
F
T
K
S
F
K
E
F
I
D
A
C
L
N
K
D
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
-
I
-------------------
107
Blastp_CBE
59.18
39%
-15
- C2 -
-
4QNA
1
STK24_HUMAN
A:
[25-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
130
Blastp_CBE
59.15
39%
-17
- C2 -
-
4U8Z
1
STK24_HUMAN
A:
[10-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
--
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
210
Blastp_CBE
59.13
35%
-34
- C2 -
-
2GCD
1
TAOK2_RAT
A:
[12-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
K
L
F
S
D
L
R
E
I
---
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
---
K
M
S
---
Y
S
G
K
-
Q
S
N
E
K
WQD--
I
I
K
-
E
V
R
F
L
Q
K
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
------
R
------
E
H
T
A
W
L
V
M
E
Y
C
L
G
S
A
S
D
L
-
L
E
-
V
--
H
--
K
-
K
P--------
L
Q
---
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
---
P
G
--
L
V
K
L
G
D
F
G
-----
S
A
S
I
M
A
P
A
N
F
V
G
T
P
Y
W
M
A
P
E
V
I
-----
L
-----
A
M
DEG
Q
Y
-
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
-
A
Q
N
--
E
----
S
-------
P
A
---
L
Q
S
--
G
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-
V
L
R
E
R
P
P
T
V
I
M
D
L
I
Q
R
T
K
--
109
Blastp_CBE
59.07
39%
-17
- C2 -
-
4QMY
2
STK24_HUMAN
A:
[25-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
108
Blastp_CBE
58.99
39%
-13
- C2 -
-
4QMZ
1
STK24_HUMAN
A:
[25-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
103
Blastp_CBE
58.85
39%
-14
- C2 -
-
3A7H
1
STK24_HUMAN
B:
[18-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
121
Blastp_CBE
58.74
39%
-11
- C2 -
-
4QML
2
STK24_HUMAN
A:
[25-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
122
Blastp_CBE
58.73
39%
-18
- C2 -
-
4W8E
1
STK24_HUMAN
A:
[10-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
--
N
Y
--
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
117
Blastp_CBE
58.50
39%
-16
- C2 -
-
4QMP
2
STK24_HUMAN
A:
[25-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
120
Blastp_CBE
58.45
39%
-16
- C2 -
-
4QMM
3
STK24_HUMAN
A:
[25-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
212
Blastp_CBE
58.31
35%
-34
- C2 -
-
1U5R
1
TAOK2_RAT
A:
[51-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
K
L
F
S
D
L
R
E
I
---
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
---
K
M
S
---
Y
S
G
K
-
Q
S
N
E
K
WQD--
I
I
K
-
E
V
R
F
L
Q
K
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
------
R
------
E
H
T
A
W
L
V
M
E
Y
C
L
G
S
A
S
D
L
-
L
E
-
V
--
H
--
K
-
K
P--------
L
Q
---
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
---
P
G
--
L
V
K
L
G
D
F
G
-----
S
A
S
I
M
A
P
A
N
F
V
G
T
P
Y
W
M
A
P
E
V
I
-----
L
-----
A
M
DEG
Q
Y
-
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
-
A
Q
N
--
E
----
S
-------
P
A
---
L
Q
S
--
G
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-
V
L
R
E
R
P
P
T
V
I
M
D
L
I
Q
R
T
K
--
111
Blastp_CBE
58.21
39%
-14
- C2 -
-
4QMW
2
STK24_HUMAN
A:
[25-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
118
Blastp_CBE
57.69
39%
-15
- C2 -
-
4QMO
3
STK24_HUMAN
A:
[25-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
P
E
E
L
F
T
K
L
E
K
I
---
G
K
G
S
F
G
E
V
F
K
G
I
D
N
R
T
Q
K
V
V
A
I
K
---
I
I
D
---
L
E
E
A
-
E
D
E
I
E
-----
D
I
Q
Q
E
I
T
V
L
S
Q
C
-
D
S
P
Y
V
T
K
Y
Y
G
S
Y
L
------
K
------
D
T
K
L
W
I
I
M
E
Y
L
G
G
G
S
A
L
D
-
L
L
-
E
--
P
--
G
-
P
---------
L
D
---
E
T
Q
I
A
T
I
L
R
E
I
L
K
G
L
D
Y
L
H
S
E
K
K
I
H
R
D
I
K
A
A
N
V
L
L
S
E
---
H
G
--
E
V
K
L
A
D
F
G
V
A
G
Q
L
T
D
T
Q
I
K
R
-
N
F
V
G
T
P
F
W
M
A
P
E
V
I
-----
K
-----
Q
S
---
A
Y
-
D
S
K
A
D
I
W
S
L
G
I
T
A
I
E
L
A
R
G
E
P
P
H
S
E
L
H
P
M
K
V
L
F
L
I
-
P
K
N
--
N
----
P
-------
P
T
---
L
E
G
----
N
Y
S
K
P
L
K
E
F
V
E
A
C
L
N
K
E
P
S
F
R
P
T
A
K
E
L
L
K
H
K
F
I
L
R
N
A
K
K
T
S
Y
L
T
E
L
I
D
R
Y
K
--
209
Blastp_CBE
57.60
35%
-33
- C2 -
-
2GCD
1
TAOK2_RAT
B:
[12-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
K
L
F
S
D
L
R
E
I
---
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
---
K
M
S
---
Y
S
G
K
-
Q
S
N
E
K
WQD--
I
I
K
-
E
V
R
F
L
Q
K
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
------
R
------
E
H
T
A
W
L
V
M
E
Y
C
L
G
S
A
S
D
L
-
L
E
-
V
--
H
--
K
-
K
P--------
L
Q
---
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
---
P
G
--
L
V
K
L
G
D
F
G
-----
S
A
S
I
M
A
P
A
N
F
V
G
T
P
Y
W
M
A
P
E
V
I
-----
L
-----
A
M
DEG
Q
Y
-
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
-
A
Q
N
--
E
----
S
-------
P
A
---
L
Q
S
--
G
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-
V
L
R
E
R
P
P
T
V
I
M
D
L
I
Q
R
T
K
--
19
PsiBlast_PDB
57.58
83%
18
- C2 -
-
4XBR
1
INKA1_HUMAN (first)
A:
[25-364]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
Q
R
E
P
Q
R
V
S
H
E
Q
F
R
A
A
L
Q
L
V
V
D
P
G
D
P
R
S
Y
L
D
N
F
I
K
I
---
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
---
K
M
D
---
L
R
K
Q
-
Q
R
R
E
L
-----
L
F
N
-
E
V
V
I
M
R
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
------
V
------
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
-
I
V
-
T
--
H
--
T
-
R
---------
M
N
---
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
---
D
G
--
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
E
V
P
R
R
K
G
L
V
G
T
P
Y
W
M
A
P
E
L
I
-----
S
-----
R
L
---
P
Y
-
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
M
I
-
R
D
N
--
L
----
P
-------
P
R
---
L
K
N
--
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
H
P
F
-
L
A
K
A
G
P
P
A
S
I
V
P
L
M
R
Q
N
R
--
211
Blastp_CBE
57.43
35%
-34
- C2 -
-
1U5R
1
TAOK2_RAT
B:
[51-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
E
K
L
F
S
D
L
R
E
I
---
G
H
G
S
F
G
A
V
Y
F
A
R
D
V
R
N
S
E
V
V
A
I
K
---
K
M
S
---
Y
S
G
K
-
Q
S
N
E
K
WQD--
I
I
K
-
E
V
R
F
L
Q
K
L
-
R
H
P
N
T
I
Q
Y
R
G
C
Y
L
------
R
------
E
H
T
A
W
L
V
M
E
Y
C
L
G
S
A
S
D
L
-
L
E
-
V
--
H
--
K
-
K
P--------
L
Q
---
E
V
E
I
A
A
V
T
H
G
A
L
Q
G
L
A
Y
L
H
S
H
N
M
I
H
R
D
V
K
A
G
N
I
L
L
S
E
---
P
G
--
L
V
K
L
G
D
F
G
-----
S
A
S
I
M
A
P
A
N
F
V
G
T
P
Y
W
M
A
P
E
V
I
-----
L
-----
A
M
DEG
Q
Y
-
D
G
K
V
D
V
W
S
L
G
I
T
C
I
E
L
A
E
R
K
P
P
L
F
N
M
N
A
M
S
A
L
Y
H
I
-
A
Q
N
--
E
----
S
-------
P
A
---
L
Q
S
--
G
H
-
W
S
E
Y
F
R
N
F
V
D
S
C
L
Q
K
I
P
Q
D
R
P
T
S
E
V
L
L
K
H
R
F
-
V
L
R
E
R
P
P
T
V
I
M
D
L
I
Q
R
T
K
--
514
HHSearch
57.13
41%
-33
- C2 -
-
6AO5
1
STK3_HUMAN
A:
[13-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
E
K
L
---
G
E
G
S
Y
G
S
V
F
K
A
I
H
-----
V
V
A
I
K
---
Q
-----------
D
L
Q
E
-----
I
I
K
-
E
I
S
I
M
Q
Q
C
-
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
----------------
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
-
I
I
-
R
--
L
RN
K
-
T
---------
L
I
---
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
N
T
---
E
G
--
H
A
K
L
A
D
F
G
V
A
------------
V
I
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
E
I
---
G
Y
-
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
-
P
T
N
--
P
----
P
-------
P
T
---
F
R
K
--
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
-
I
K
N
A
K
P
V
S
I
L
----------
125
Blastp_CBE
56.94
39%
-15
- C2 -
-
5D7A
1
TNIK_HUMAN
A:
[25-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
---
V
T
G
D
-
E
E
E
E
I
-----
K
-
Q
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKNPPG
M
------
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
V
T
D
-
L
I
-
K
--
N
--
T
-
K
---------
G
N
TLK
E
E
W
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
H
K
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
--
E
V
K
L
V
D
F
G
V
-----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
-
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
-
P
R
N
--
P
----
A
-------
P
R
---
L
K
S
---
K
K
W
S
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
R
P
A
T
E
Q
L
M
K
H
P
F
-
I
R
------------------
182
Blastp_CBE
56.93
35%
-40
- C2 -
-
2JFL
6
SLK_HUMAN
A:
[34-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
D
F
W
E
I
I
G
E
L
---
G
D
G
A
F
G
K
V
Y
K
A
Q
N
K
E
T
S
V
L
A
A
A
K
---
V
I
D
---
T
K
S
E
-
E
E
L
E
D
-----
Y
M
V
-
E
I
D
I
L
A
S
C
-
D
H
P
N
I
V
K
L
L
D
A
F
Y
------
Y
------
E
N
N
L
W
I
L
I
E
F
C
A
G
G
A
V
D
A
-
V
M
-
L
--
E
--
L
-
E
RP-------
L
T
---
E
S
Q
I
Q
V
V
C
K
Q
T
L
D
A
L
N
Y
L
H
D
N
K
I
I
H
R
D
L
K
A
G
N
I
L
F
T
L
---
D
G
--
D
I
K
L
A
D
F
G
V
S
A
K
N
T
R
T
-
I
Q
R
R
D
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETS
K
-----
D
R
---
P
Y
-
D
Y
K
A
D
V
W
S
L
G
I
T
L
I
E
M
A
E
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
-
A
K
S
--
E
----
P
-------
P
T
---
L
A
Q
--
P
S
R
W
S
S
N
F
K
D
F
L
K
K
C
L
E
K
N
V
D
A
R
W
T
T
S
Q
L
L
Q
H
P
F
-
V
T
V
-----------------
196
Blastp_CBE
56.91
37%
-47
- C2 -
-
4U44
2
M4K4_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
---
V
T
E
D
-
E
E
E
E
I
-----
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
------
K
KSH---
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
-
K
--
N
--
T
-
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
--
E
V
K
L
V
D
F
G
V
S
A
----------
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
-
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
-
P
R
N
--
P
----
P
-------
P
R
---
L
K
S
--
K
K
W
S
K
K
F
F
S
-
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
------------------
84
Blastp_CBE
56.70
40%
-28
- C2 -
-
6AO5
1
STK3_HUMAN
A:
[13-278]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
L
E
K
L
---
G
E
G
S
Y
G
S
V
F
K
A
I
H
-----
V
V
A
I
K
---
Q
--------
D
-
L
Q
E
-------
I
I
K
-
E
I
S
I
M
Q
Q
C
-
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
----------------
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
-
I
I
-
R
LR
N
--
K
-
T
---------
L
I
---
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
N
T
---
E
G
--
H
A
K
L
A
D
F
G
V
A
------------
V
I
G
T
P
F
W
M
A
P
E
V
I
-----
Q
-----
E
I
---
G
Y
-
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
I
-
P
T
N
--
P
----
P
-------
P
T
---
F
R
K
--
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
-
I
K
N
A
K
P
V
S
I
L
R
D
L
I
T
E
----
199
Blastp_CBE
56.24
37%
-0
- C2 -
-
4U40
1
M4K4_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
---
V
T
E
D
-
E
E
E
E
I
-----
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
------
K
KSPPGH
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
-
K
--
N
--
T
-
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
--
E
V
K
L
V
D
F
G
V
S
A
Q
L
D
R
T
V
G
R
R
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
-
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
-
P
R
N
--
P
----
P
-------
P
R
---
L
K
S
--
K
K
W
S
K
K
F
F
S
-
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
------------------
124
Blastp_CBE
55.83
39%
-10
- C2 -
-
5D7A
1
TNIK_HUMAN
B:
[25-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
---
V
T
G
D
-
E
E
E
E
I
-----
K
-
Q
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKNPPG
M
------
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
V
T
D
-
L
I
-
K
--
N
--
T
-
K
---------
G
N
TLK
E
E
W
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
H
K
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
--
E
V
K
L
V
D
F
G
V
-----------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
-
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
-
P
R
N
--
P
----
A
-------
P
R
---
L
K
S
---
K
K
W
S
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
R
P
A
T
E
Q
L
M
K
H
P
F
-
I
R
------------------
183
Blastp_CBE
55.68
37%
-33
- C2 -
-
6HXF
4
STK10_HUMAN
D:
[16-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
---
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
---
V
I
E
---
T
K
S
E
-
E
E
L
E
D
-----
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
------
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
-
I
M
-
L
--
E
--
L
-
D
RG-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
---
E
G
--
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
-
L
Q
K
R
D
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCEM--------
T
---
P
Y
-
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
-
A
K
S
--
D
----
P
-------
P
T
---
L
L
T
--
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-------------------
147
Blastp_CBE
54.21
38%
-4
- C2 -
-
6RA7
2
?
A:
[23-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
---
V
T
G
D
-
E
E
E
E
I
-----
K
-
Q
-
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
KKNPPG
M
------
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
V
T
D
-
L
I
-
K
--
N
--
T
-
K
---------
G
N
TLK
E
E
W
I
A
Y
I
C
R
E
I
L
R
G
L
S
H
L
H
Q
H
K
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
--
E
V
K
L
V
D
F
G
V
S
A
Q
L
D
R
T
-
V
G
R
R
N
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
-
D
F
K
S
D
L
W
S
L
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
-
P
R
N
--
P
----
A
-------
P
R
---
L
K
S
---
K
K
W
S
K
K
F
Q
S
F
I
E
S
C
L
V
K
N
H
S
Q
R
P
A
T
E
Q
L
M
K
H
P
F
-
I
R
------------------
176
Blastp_CBE
54.06
38%
-35
- C2 -
-
6EIM
5
STK10_HUMAN
A:
[16-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
---------
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
---
V
I
E
---
T
K
S
E
-
E
E
L
E
D
-----
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
------
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
-
I
M
-
L
--
E
--
L
-
D
RG-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
---
E
G
--
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
L
Q
K
R
D
S
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCETM
K
-----
D
T
---
P
Y
-
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
A
I
-
A
A
S
--
D
----
P
-------
P
T
---
L
L
T
--
P
S
K
W
S
V
E
F
R
D
F
L
A
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-------------------
195
Blastp_CBE
52.37
37%
-6
- C2 -
-
4U45
1
M4K4_HUMAN
A:
[32-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
G
N
G
T
Y
G
Q
V
Y
K
G
R
H
V
K
T
G
Q
L
A
A
I
K
---
V
M
D
---
V
T
E
D
-
E
E
E
E
I
-----
K
L
--
E
I
N
M
L
K
K
Y
S
H
H
R
N
I
A
T
Y
Y
G
A
F
I
------
K
KSPP--
D
D
Q
L
W
L
V
M
E
F
C
G
A
G
S
I
T
D
-
L
V
-
K
--
N
--
T
-
K
---------
G
N
TLK
E
D
W
I
A
Y
I
S
R
E
I
L
R
G
L
A
H
L
H
I
H
H
V
I
H
R
D
I
K
G
Q
N
V
L
L
T
E
---
N
A
--
E
V
K
L
V
D
F
G
V
S
A
---------
N
T
F
I
G
T
P
Y
W
M
A
P
E
V
I
-----
A
CDENP
D
A
---
T
Y
-
D
Y
R
S
D
L
W
S
C
G
I
T
A
I
E
M
A
E
G
A
P
P
L
C
D
M
H
P
M
R
A
L
F
L
I
-
P
R
N
--
P
----
P
-------
P
R
---
L
K
S
--
K
K
W
S
K
K
F
F
S
-
F
I
E
G
C
L
V
K
N
Y
M
Q
R
P
S
T
E
Q
L
L
K
H
P
F
-
I
R
------------------
388
Blastp_CBE
51.83
31%
-35
- C2 -
-
5XZV
1
?
B:
[204-466]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
---
I
I
S
---
K
R
K
----
M
D
G
-----
V
T
R
-
E
L
E
V
L
Q
K
L
-
N
H
P
R
I
V
R
L
K
G
F
Y
E
------
D
------
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
-
F
V
-
A
A-
H
--
G
-
A
---------
V
G
---
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
E
Q
---
D
D
PV
L
V
K
I
T
D
F
G
L
------------
T
F
C
G
T
L
A
Y
V
A
P
E
V
I
-----------
R
N
---
E
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
S
G
S
T
Q
D
Q
L
Y
K
Q
I
G
R
G
S
--
Y
----
H
-------
E
G
P--
L
K
D
--
F
-
R
I
S
E
E
A
R
D
F
I
D
S
L
L
Q
V
D
P
N
N
R
S
T
A
A
K
A
L
N
H
P
W
-
I
-------------------
185
Blastp_CBE
51.80
37%
-28
- C2 -
-
6HXF
5
STK10_HUMAN
B:
[16-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
P
N
E
V
W
E
I
V
G
E
L
---
G
D
G
A
F
G
K
V
Y
K
A
K
N
K
E
T
G
A
L
A
A
A
K
---
V
I
E
---
T
K
S
E
-
E
E
L
E
D
-----
Y
I
V
-
E
I
E
I
L
A
T
C
-
D
H
P
Y
I
V
K
L
L
G
A
Y
Y
------
H
------
D
G
K
L
W
I
M
I
E
F
C
P
G
G
A
V
D
A
-
I
M
-
L
--
E
--
L
-
D
RG-------
L
T
---
E
P
Q
I
Q
V
V
C
R
Q
M
L
E
A
L
N
F
L
H
S
K
R
I
I
H
R
D
L
K
A
G
N
V
L
M
T
L
---
E
G
--
D
I
R
L
A
D
F
G
V
S
A
K
N
L
K
T
-
L
Q
K
R
D
F
I
G
T
P
Y
W
M
A
P
E
V
V
MCEM-
K
-----
D
T
---
P
Y
-
D
Y
K
A
D
I
W
S
L
G
I
T
L
I
E
M
A
Q
I
E
P
P
H
H
E
L
N
P
M
R
V
L
L
K
I
-
A
K
S
--
D
----
P
-------
P
T
---
L
L
T
--
P
S
K
W
S
V
E
F
R
D
F
L
K
I
A
L
D
K
N
P
E
T
R
P
S
A
A
Q
L
L
E
H
P
F
-
V
-------------------
220
Blastp_CBE
50.51
32%
-5
- C2 -
-
3HZT
9
?
A:
[11-295]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
---
G
S
G
A
Y
G
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
IIK
K
S
S
---
V
T
T
T
-
S
N
S
G
A
-----
L
L
D
-
E
V
A
V
L
K
Q
L
-
D
H
P
N
I
M
K
L
Y
E
F
F
E
------
D
------
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
-
L
--
R
--
Q
-
K
---------
F
S
---
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
L
L
E
S
KSR
D
A
--
L
I
K
I
V
D
F
G
L
S
A
H
F
--
E
V
-------
G
T
A
Y
Y
I
A
P
E
V
L
-----------
R
K
---
K
Y
-
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
G
Q
T
D
Q
E
I
L
K
R
V
-
E
K
G
--
K
FSFD
P
-------
P
------
D
--
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
E
E
A
L
N
H
P
W
-
I
-------------------
270
Blastp_CBE
50.04
32%
-9
- C2 -
-
2CN5
1
CHK2_HUMAN
A:
[24-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
---
I
I
S
---
K
R
--------N----
V
E
T
-
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
F
F
------
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
-
G
--
N
--
K
-
R
---------
L
K
---
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
--
L
I
K
I
T
D
F
G
H
-
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
-----
S
V
GTA
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
E
H
R
T
Q
V
--
S
L
-
K
D
Q
--
I
----
T
SGKYNFI
P
E
---
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
Q
------------------
257
Blastp_CBE
50.02
32%
-15
- C2 -
-
4BDA
8
CHK2_HUMAN
A:
[20-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
---
I
I
S
---
K
---------N----
V
E
T
-
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
F
F
------
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
-
G
--
N
--
K
-
R
---------
L
K
---
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
--
L
I
K
I
T
D
F
G
H
-
S
K
I
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
-----
S
V
GTA
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
E
H
R
T
Q
V
--
S
L
-
K
D
Q
--
I
----
T
SGKYNFI
P
E
---
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
Q
------------------
151
Blastp_CBE
49.98
38%
-40
- C2 -
-
2VWI
2
OXSR1_HUMAN
A:
[23-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
G
---
T
A
V
V
Q
A
A
Y
C
----
E
K
V
A
I
K
---
R
I
N
-------------------------
A
M
S
Q
C
-
H
H
P
N
I
V
S
Y
Y
T
S
F
V
------
V
------
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
V
L
D
-
I
I
-
K
--
H
--
I
-
V
AKGEHKSGV
L
D
---
E
S
T
I
A
T
I
L
R
E
V
L
E
G
L
E
Y
L
H
K
N
G
Q
I
H
R
D
V
K
A
G
N
I
L
L
G
E
---
D
G
--
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
----------
G
T
P
C
W
M
A
P
E
V
M
-----
E
-----
Q
V
R--
G
Y
-
D
F
K
A
D
I
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
-
L
Q
N
--
D
----
P
-------
P
S
LET---EM
L
K
K
Y
G
K
S
F
R
K
M
I
S
L
C
L
Q
K
D
P
E
K
R
P
T
A
A
E
L
L
R
H
K
F
-
F
-------------------
256
Blastp_CBE
49.39
32%
-4
- C2 -
-
4BDB
10
CHK2_HUMAN
A:
[18-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
---
I
I
S
---
K
---------LN---
V
E
T
-
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
F
F
------
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
-
G
--
N
--
K
-
R
---------
L
K
---
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
--
L
I
K
I
T
D
F
G
H
-
S
K
I
L
-
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
-----
S
V
GTA
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
E
H
R
T
Q
V
--
S
L
-
K
D
Q
--
I
----
T
SGKYNFI
P
E
---
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
Q
------------------
259
Blastp_CBE
49.26
32%
-1
- C2 -
-
4A9T
4
CHK2_HUMAN
A:
[24-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
S
---
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
---
I
I
S
---
K
---------PALN-
V
E
T
-
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
F
F
------
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
-
G
--
N
--
K
-
R
---------
L
K
---
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
--
L
I
K
I
T
D
F
G
H
-
S
K
I
L
G
E
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
-----
S
V
GTA
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
E
H
R
T
Q
V
--
S
L
-
K
D
Q
--
I
----
T
SGKYNFI
P
E
---
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
Q
------------------
225
Blastp_CBE
48.65
32%
-14
- C2 -
-
5EAK
1
MARK2_HUMAN
B:
[23-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
---
I
I
D
---
K
T
Q
L
-
N
S
S
S
L
QK---
L
F
R
-
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
------
T
------
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
-
A
--
H
--
G
-
R
---------
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
---
D
M
--
N
I
K
I
A
D
F
G
--------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
-----
G
K
---
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
----
Q
N
L
K
E
L
-
R
E
R
V-
L
----
R
-------
G
K
---
Y
R
I
--
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
-------------------------
268
Blastp_CBE
48.48
32%
-6
- C2 -
-
2WTC
1
CHK2_HUMAN
A:
[20-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
---
I
I
S
---
K
---------PALN-
V
E
T
-
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
F
F
------
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
-
G
--
N
--
K
-
R
---------
L
K
---
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
--
L
I
K
I
T
D
F
G
H
-
S
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
-----
S
V
GTA
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
E
H
R
T
Q
V
--
S
L
-
K
D
Q
--
I
----
T
SGKYNFI
P
E
---
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
Q
------------------
226
Blastp_CBE
48.31
32%
-21
- C2 -
-
5EAK
1
MARK2_HUMAN
A:
[23-263]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
---
I
I
D
---
K
T
Q
L
-
N
S
S
S
L
QK---
L
F
R
-
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
------
T
------
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
-
A
--
H
--
G
-
R
---------
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
---
D
M
--
N
I
K
I
A
D
F
G
F
S
------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
-----
G
K
---
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
----
Q
N
L
K
E
L
-
R
E
R
V-
L
----
R
-------
G
K
---
Y
R
I
--
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
-------------------------
258
Blastp_CBE
48.15
32%
2
- C2 -
-
4A9U
10
CHK2_HUMAN
A:
[20-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
S
G
A
C
G
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
---
I
I
S
---
K
---------DPALN
V
E
T
-
E
I
E
I
L
K
K
L
-
N
H
P
C
I
I
K
I
-
K
N
F
F
------
D
------
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
-
G
--
N
--
K
-
R
---------
L
K
---
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
L
L
S
S
QEE
D
C
--
L
I
K
I
T
D
F
G
H
-
S
K
I
L
--
T
S
L
M
R
T
L
C
G
T
P
T
Y
L
A
P
E
V
L
-----
V
-----
S
V
GTA
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
-
F
S
E
H
R
T
Q
V
--
S
L
-
K
D
Q
--
I
----
T
SGKYNFI
P
E
---
V
----
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
E
E
A
L
R
H
P
W
-
L
Q
------------------
222
Blastp_CBE
46.40
32%
-8
- C2 -
-
5KZ8
1
MARK2_HUMAN
A:
[41-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
---
I
I
D
---
K
T
Q
L
-
N
S
S
S
L
QK---
L
F
R
-
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
------
T
------
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
-
A
--
H
--
G
-
R
---------
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
---
D
M
--
N
I
K
I
A
D
F
G
---------------
C
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
-----
G
K
---
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
----
Q
N
L
K
E
L
-
R
E
R
V-
L
----
R
-------
G
K
---
Y
R
I
--
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
-------------------------
223
Blastp_CBE
46.29
32%
-9
- C2 -
-
5KZ7
1
MARK2_HUMAN
B:
[41-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
---
I
I
D
---
K
T
Q
L
-
N
S
S
S
L
QK---
L
F
R
-
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
------
T
------
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
-
A
--
H
--
G
-
R
---------
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
---
D
M
--
N
I
K
I
A
D
F
-----------------
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
-----
G
K
-----D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
------
N
L
K
E
L
-
R
E
R
V-
L
----
R
-------
G
K
---
Y
R
I
--
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
-------------------------
389
Blastp_CBE
45.97
31%
-14
- C2 -
-
5XZV
1
RAD53_YEAST
A:
[204-465]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
---
G
Q
G
A
F
A
T
V
K
K
A
I
E
R
T
T
G
K
T
F
A
V
K
---
I
I
S
---
K
R
K
V
I
G
N
M
D
G
-----
V
T
R
-
E
L
E
V
L
Q
K
L
-
N
H
P
R
I
V
R
L
K
G
F
Y
E
------
D
------
T
E
S
Y
Y
M
V
M
E
F
V
S
G
G
D
L
M
D
-
F
V
-
A
A-
H
--
G
-
A
---------
V
G
---
E
D
A
G
R
E
I
S
R
Q
I
L
T
A
I
K
Y
I
H
S
M
G
I
S
H
R
D
L
K
P
D
N
I
L
I
E
Q
---
D
D
PV
L
V
K
I
T
D
F
G
L
-
A
K
--------------
L
A
Y
V
A
P
E
V
I
------------
N
---
E
Y
-
S
S
L
V
D
M
W
S
M
G
C
L
V
Y
V
I
L
T
G
H
L
P
F
--
S
T
Q
D
Q
L
Y
K
Q
I
G
R
G
S
--------------------
L
K
D
--
F
-
R
I
S
E
E
A
R
D
F
I
D
S
L
---
D
P
N
N
--
T
A
A
K
A
L
N
H
P
W
---------------------
224
Blastp_CBE
45.90
32%
-9
- C2 -
-
5KZ7
1
MARK2_HUMAN
A:
[41-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
---
I
I
D
---
K
T
Q
L
-
N
S
S
S
L
QK---
L
F
R
-
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
------
T
------
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
-
A
--
H
--
G
-
R
---------
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
---
D
M
--
N
I
K
I
A
D
F
-----------------
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
-----
G
K
-----D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
------
N
L
K
E
L
-
R
E
R
V-
L
----
R
-------
G
K
---
Y
R
I
--
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
-------------------------
221
Blastp_CBE
45.60
32%
-0
- C2 -
-
5KZ8
1
MARK2_HUMAN
B:
[41-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
---
I
I
D
---
K
T
Q
L
-
N
S
S
S
L
QK---
L
F
R
-
E
V
R
I
M
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
------
T
------
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
-
A
--
H
--
G
-
R
---------
M
K
---
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
---
D
M
--
N
I
K
I
A
D
F
-----------------
G
S
P
P
Y
A
A
P
E
L
F
-----
Q
-----
G
K
---
K
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
----
Q
N
L
K
E
L
-
R
E
R
V-
L
----
R
-------
G
K
---
Y
R
I
--
P
F
Y
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
E
Q
I
M
-------------------------
360
Blastp_CBE
43.97
32%
-0
- C2 -
-
6C0U
4
KAPCA_HUMAN
A:
[36-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
KTL
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
G
R
---------
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
351
Blastp_CBE
43.56
32%
-4
- C2 -
-
3POO
2
KAPCA_HUMAN
A:
[33-255]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
KTL
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
G
R
---------
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
355
Blastp_CBE
43.25
32%
-4
- C2 -
-
3OVV
2
KAPCA_HUMAN
A:
[33-251]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
A
Q
N
T
A
H
L
D
Q
F
E
R
I
KTL
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
G
R
---------
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
409
Blastp_CBE
43.14
32%
-18
- C2 -
-
5LCR
5
KAPCA_CRIGR
A:
[52-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
G
R
---------
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
407
Blastp_CBE
43.02
32%
-22
- C2 -
-
5LCU
5
KAPCA_CRIGR
A:
[52-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
G
R
---------
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
377
Blastp_CBE
43.02
31%
-51
- C2 -
-
5LOH
2
GWL_HUMAN
B:
[96-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
H
L
Y
Y
S
L
Q
------
S
------
A
N
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
-
L
L
H
I
--
Y
--
G
-
Y
---------
F
D
---
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
R
H
G
I
I
H
R
D
L
K
P
D
N
M
L
I
S
N
---
E
G
--
H
I
K
L
T
D
F
G
L
---------------
G
T
P
D
Y
L
A
P
E
L
L
-----
L
-----
G
R
---
A
H
-
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
I
P
P
F
N
D
E
T
P
Q
Q
V
F
Q
N
I
-
L
K
R
--
D
----
I
-------
P
W
---
P
E
G
--
E
E
K
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
R
A
G
M
K
E
L
K
R
H
P
L
-
F
-------------------
417
Blastp_CBE
42.94
33%
-16
- C2 -
-
2GNL
1
KAPCA_BOVIN
A:
[49-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
G
R
---------
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
K
V
A
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
396
Blastp_CBE
42.91
32%
-13
- C2 -
-
5N1E
4
KAPCA_CRIGR
A:
[52-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
G
R
---------
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
325
Blastp_CBE
42.89
33%
-24
- C2 -
-
2GNF
1
KAPCA_BOVIN
A:
[49-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
---
D
-
M
F
-
S
--
H
--
L
-
R
RIGR-----
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
K
V
A
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
327
Blastp_CBE
42.72
33%
-29
- C2 -
-
2GNH
2
KAPCA_BOVIN
A:
[49-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
M
P
G
G
---
D
-
M
F
-
S
--
H
--
L
-
R
RIGR-----
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
K
V
A
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
406
Blastp_CBE
42.50
32%
-12
- C2 -
-
5M0B
3
KAPCA_CRIGR
A:
[52-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
G
R
---------
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
418
Blastp_CBE
42.39
33%
-17
- C2 -
-
2GNJ
1
KAPCA_BOVIN
A:
[49-250]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
---
G
T
G
S
F
G
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
G
R
---------
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
K
V
A
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
473
Blastp_CBE
37.70
32%
-20
- C2 -
-
5N3G
4
KAPCA_CRIGR
A:
[52-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
-
G
---------
R
F
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
420
Blastp_CBE
37.50
32%
-19
- C2 -
-
5N3N
4
KAPCA_CRIGR
A:
[50-251]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
-
G
---------
R
F
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
465
Blastp_CBE
37.48
32%
-18
- C2 -
-
5N3P
4
KAPCA_CRIGR
A:
[52-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
-
G
---------
R
F
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
472
Blastp_CBE
37.13
32%
-16
- C2 -
-
5N3H
3
KAPCA_CRIGR
A:
[52-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
-
G
---------
R
F
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
461
Blastp_CBE
36.41
32%
-18
- C2 -
-
5N3T
4
KAPCA_CRIGR
A:
[52-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
-
G
---------
R
F
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
462
Blastp_CBE
36.35
32%
-16
- C2 -
-
5N3S
5
KAPCA_CRIGR
A:
[52-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
-
G
---------
R
F
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------
403
Blastp_CBE
29.63
32%
-37
- C2 -
-
5M0U
5
KAPCA_CRIGR
A:
[3-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
G
T
G
S
F
G
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
---
I
L
D
KQK
V
V
K
L
-
K
Q
I
E
H
-----
T
L
N
-
E
K
R
I
L
Q
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
------
D
------
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
-
R
--
R
--
I
G
R
---------
F
S
---
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
---
Q
G
--
Y
I
Q
V
T
D
F
G
F
----
A
K
R
V
K
G
R
T
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
-----
L
-----
S
K
---
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
A
D
Q
P
I
Q
I
Y
E
K
I
------------------------------------------------------------------------------------