@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PHKG1_HUMAN: (2020-09-19 )
MTRDEALPDSHSAQDFYENYEPKEILGRGVSSVVRRCIHKPTSQEYAVKVIDVTGGGSFSPEEVRELREATLKEVDILRKVSGHPNIIQLKDTYETNTFFFLVFDLMKRGELFDYLTEKVTLSEKETRKIMRALLEVICTLHKLNIVHRDLKPENILLDDNMNIKLTDFGFSCQLEPGERLREVCGTPSYLAPEIIECSMNEDHPGYGKEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIMSGNYQFGSPEWDDYSDTVKDLVSRFLVVQPQNRYTAEEALAHPFFQQYLVEEVRHFSPRGKFKVIALTVLASVRIYYQYRRVKPVTREIVIRDPYALRPLRRLIDAYAFRIYGHWVKKGQQQNRAALFENTPKAVLLSLAEEDY
Atome Classification :
(241 SA)
.........10..--.....---.20---...-----.....30.---.......40........50.---.---......60......--.--.70-...-......-80.-.......90........100.......110..-.....-120--.--........130.......140.......150....-.---.----.---160--.---.---.---......170.---.-.-.-.-..-180--..-.....190.....-..200.....-..210.......220.......230----.-...-----..-.-------..240.......250.......260.......270.......---280.....----------.-----------.------------290----------.------------.-----------.---------------.....300.......310.......320.......330.......340.......350.......360.......370.......380.....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MTRDEALPDSH
S
A
--
Q
D
F
Y
E---NY
E
---
P
K
E
-----
I
L
G
R
G
V
S
S
---
V
V
R
R
C
IHKPTSQ
E
Y
A
V
K
V
I
D
---V---TGGGSF
S
P
E
E
V
R
E
L
--
R
--
E
A
--
T
L
K
-
E
V
D
I
L
R
-
K
VS-GHP
N
I
I
Q
L
K
DTYET
N
T
F
F
F
L
V
F
D
L
M
KR
G
E
L
F
D
-
Y
L
T
E
K-V----T--L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
T
L
H
K
L
N
I
V
HRDLKPE
N
I
-
L
---L----D---D----N---M---
N
---
I
K
L
TDF
G
F
S
C
---Q-L-E-
P
-
G
E
-
R
L
R
--
E
V
-CGTP
S
Y
L
A
P
E
I
I
E
-CSMNEDHPGY-GKEVDMWSTG
V
I
M
Y
TLLAGSPP
F
------
W
-
H
R
K
-----
Q
M
-
L
-------
M
L
R
M
I
MSGNYQFGSPEWD
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
VQPQNRY
T
A
---
E
E
A
L
A
H
P
F
----------
F
-----------
Q
------------
Q
Y
-----------
L
------------
V
-----------
E
---------------
E
V
R
HFSPRG
K
F
K
V
I
A
L
T
V
L
A
S
V
R
I
Y
Y
Q
Y
RRVKPVT
R
E
I
V
IRDP
Y
A
L
R
P
L
R
R
L
I
D
A
Y
A
F
R
I
Y
G
H
W
V
KKGQQQ
N
R
A
A
L
FENT
P
K
A
V
L
L
S
L
AEEDY
3
PsiBlast_PDB
97.94
95%
-130
- C1 -
-
2PHK
2
PHKG1_RABIT
A:
[2-277]
-----------------
F
Y
E
---
N
Y
E
---
P
K
E
-----
I
L
G
R
G
V
S
S
---
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
---
V
---
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
--
R
--
E
A
--
T
L
K
-
E
V
D
I
L
R
-
K
V
S
-
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
-
Y
L
T
E
K
-
V
----
T
--
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
D
----
D
---
M
---
N
---
I
K
L
T
D
F
G
F
S
C
---
Q
-
L
-
D
-
P
-
G
E
-
K
L
R
--
E
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
-
H
R
K
-----
Q
M
-
L
-------
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
---
E
E
A
L
A
H
P
F
----------
F
-----------
Q
------------
Q
Y
-------------------------------------------------------------------------------------------------------------------------------------------------
573
HHSearch
97.40
95%
-130
- C1 -
-
2PHK
2
PHKG1_RABIT
A:
[2-276]
-----------------
F
Y
E
---
N
Y
E
---
P
K
E
-----
I
L
G
R
G
V
S
S
---
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
---
V
---
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
--
R
--
E
A
--
T
L
K
-
E
V
D
I
L
R
-
K
V
S
-
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
-
Y
L
T
E
K
-
V
----
T
--
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
D
----
D
---
M
---
N
---
I
K
L
T
D
F
G
F
S
C
---
Q
-
L
-
D
-
P
-
G
E
-
K
L
R
--
E
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
-
H
R
K
-----
Q
M
-
L
-------
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
---
E
E
A
L
A
H
P
F
----------
F
-----------
Q
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
572
HHSearch
96.20
93%
-123
- C1 -
-
1PHK
1
PHKG1_RABIT
A:
[15-291]
-----------------
F
Y
E
---
N
Y
E
---
P
K
E
-----
I
L
G
R
G
V
S
S
---
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
---
V
---
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
--
R
--
E
A
--
T
L
K
-
E
V
D
I
L
R
-
K
V
S
-
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
-
Y
L
T
E
K
-
V
----
T
--
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
D
----
D
---
M
---
N
---
I
K
L
T
D
F
G
F
S
C
---
Q
-
L
-
D
-
P
-
G
E
-
K
L
R
--
E
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
-
H
R
K
-----
Q
M
-
L
-------
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
---
E
E
A
L
A
H
P
F
----------
F
-----------
Q
------------
Q
Y
-----------
V
-------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.20
93%
-123
- C1 -
-
1PHK
1
PHKG1_RABIT
A:
[15-291]
-----------------
F
Y
E
---
N
Y
E
---
P
K
E
-----
I
L
G
R
G
V
S
S
---
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
---
V
---
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
--
R
--
E
A
--
T
L
K
-
E
V
D
I
L
R
-
K
V
S
-
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
-
Y
L
T
E
K
-
V
----
T
--
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
D
----
D
---
M
---
N
---
I
K
L
T
D
F
G
F
S
C
---
Q
-
L
-
D
-
P
-
G
E
-
K
L
R
--
E
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
-
H
R
K
-----
Q
M
-
L
-------
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
---
E
E
A
L
A
H
P
F
----------
F
-----------
Q
------------
Q
Y
-----------
V
-------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.04
93%
-119
- C1 -
-
1QL6
1
PHKG1_RABIT
A:
[11-291]
-----------
S
T
--
H
G
F
Y
E
---
N
Y
E
---
P
K
E
-----
I
L
G
R
G
V
S
S
---
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
I
I
D
---
V
---
T
G
G
G
S
F
S
A
E
E
V
Q
E
L
--
R
--
E
A
--
T
L
K
-
E
V
D
I
L
R
-
K
V
S
-
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
-
Y
L
T
E
K
-
V
----
T
--
L
S
E
K
E
T
R
K
I
M
R
A
L
L
E
V
I
C
A
L
H
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
D
----
D
---
M
---
N
---
I
K
L
T
D
F
G
F
S
C
---
Q
-
L
-
D
-
P
-
G
E
-
K
L
R
--
S
V
-
C
G
T
P
S
Y
L
A
P
E
I
I
E
-
C
S
M
N
D
N
H
P
G
Y
-
G
K
E
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
------
W
-
H
R
K
-----
Q
M
-
L
-------
M
L
R
M
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
Q
K
R
Y
T
A
---
E
E
A
L
A
H
P
F
----------
F
-----------
Q
------------
Q
Y
-----------
V
-------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
89.39
68%
-131
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[82-365]
-----
E
L
P
D
W
A
A
A
--
K
E
F
Y
Q
---
K
Y
D
---
P
K
D
-----
V
I
G
R
G
V
S
S
---
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
---
V
---
T
A
E
-
R
L
S
P
E
Q
L
E
E
V
--
R
--
E
A
--
T
R
R
-
E
T
H
I
L
R
-
Q
V
A
-
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
-
V
----
A
--
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
D
----
N
---
M
---
Q
---
I
R
L
S
D
F
G
F
S
C
---
H
-
L
-
E
-
P
-
G
E
-
K
L
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
-
H
R
R
-----
Q
I
-
L
-------
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
---
E
Q
A
L
Q
H
P
F
----------
F
-----------
E
------------
R
--------------------------------------------------------------------------------------------------------------------------------------------------
570
HHSearch
88.93
70%
-132
- C1 -
-
2Y7J
1
PHKG2_HUMAN
A:
[83-364]
------
L
P
D
W
A
A
A
--
K
E
F
Y
Q
---
K
Y
D
---
P
K
D
-----
V
I
G
R
G
V
S
S
---
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
---
V
---
T
A
E
-
R
L
S
P
E
Q
L
E
E
V
--
R
--
E
A
--
T
R
R
-
E
T
H
I
L
R
-
Q
V
A
-
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
-
V
----
A
--
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
D
----
N
---
M
---
Q
---
I
R
L
S
D
F
G
F
S
C
---
H
-
L
-
E
-
P
-
G
E
-
K
L
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
-
H
R
R
-----
Q
I
-
L
-------
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
---
E
Q
A
L
Q
H
P
F
----------
F
-----------
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.48
67%
-130
- C1 -
-
2Y7J
1
PHKG2_HUMAN
A:
[82-365]
-----
E
L
P
D
W
A
A
A
--
K
E
F
Y
Q
---
K
Y
D
---
P
K
D
-----
V
I
G
R
G
V
S
S
---
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
---
V
---
T
A
E
-
R
L
S
P
E
Q
L
E
E
V
--
R
--
E
A
--
T
R
R
-
E
T
H
I
L
R
-
Q
V
A
-
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
-
V
----
A
--
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
D
----
N
---
M
---
Q
---
I
R
L
S
D
F
G
F
S
C
---
H
-
L
-
E
-
P
-
G
E
-
K
L
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
-
H
R
R
-----
Q
I
-
L
-------
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
---
E
Q
A
L
Q
H
P
F
----------
F
-----------
E
------------
R
--------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
87.80
68%
-127
- C1 -
-
2Y7J
1
PHKG2_HUMAN
B:
[82-365]
-----
E
L
P
D
W
A
A
A
--
K
E
F
Y
Q
---
K
Y
D
---
P
K
D
-----
V
I
G
R
G
V
S
S
---
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
---
V
---
T
A
----
S
P
E
Q
L
E
E
V
--
R
--
E
A
--
T
R
R
-
E
T
H
I
L
R
-
Q
V
A
-
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
-
V
----
A
--
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
D
----
N
---
M
---
Q
---
I
R
L
S
D
F
G
F
S
C
---
H
-
L
-
E
-
P
-
G
E
-
K
L
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
-
H
R
R
-----
Q
I
-
L
-------
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
---
E
Q
A
L
Q
H
P
F
----------
F
-----------
E
------------
R
--------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
87.34
68%
-128
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[82-365]
-----
E
L
P
D
W
A
A
A
--
K
E
F
Y
Q
---
K
Y
D
---
P
K
D
-----
V
I
G
R
G
V
S
S
---
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
I
M
E
---
V
-------
R
L
S
P
E
Q
L
E
E
V
--
R
--
E
A
--
T
R
R
-
E
T
H
I
L
R
-
Q
V
A
-
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
-
V
----
A
--
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
D
----
N
---
M
---
Q
---
I
R
L
S
D
F
G
F
S
C
---
H
-
L
-
E
-
P
-
G
E
-
K
L
R
--
E
L
-
C
G
T
P
G
Y
L
A
P
E
I
L
K
-
C
S
M
D
E
T
H
P
G
Y
-
G
K
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
------
W
-
H
R
R
-----
Q
I
-
L
-------
M
L
R
M
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
L
T
A
---
E
Q
A
L
Q
H
P
F
----------
F
-----------
E
------------
R
--------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
66.25
37%
-62
- C1 -
-
2VZ6
3
KCC2A_HUMAN
B:
[20-311]
-----------------
F
Q
S
---
M
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
---
L
---
K
GAA
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
E
---
G
E
-
Q
Q
A
WF
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
---
A
E
A
L
K
H
P
W
----------
I
SHRSTVASCMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------
26
Blastp_CBE
65.40
38%
-56
- C1 -
-
2VN9
1
KCC2D_HUMAN
B:
[4-300]
-------------------
D
---
E
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
ASK-
S
---
K
----
G
---
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
--------------------------------------------------------------------------
575
HHSearch
65.22
41%
-65
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[2-298]
-----------------
M
T
D
---
E
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
K
L
-
S
------
A
R
D
--
H
--
Q
K
--
L
E
R
-
E
A
R
I
C
R
-
L
L
--
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
SKG
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
Q
A
W
F
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-
K
------
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
-----------
C
------------
Q
R
-------------------------SMMHRQETV--
D
---------------
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
----------------------------------------------------------------------------
16
PsiBlast_PDB
65.08
36%
-64
- C1 -
-
5U6Y
-
KCC2A_RAT
A:
[2-304]
------------------------
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
---
L
---
K
GAA
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
E
---
G
E
-
Q
Q
A
WF
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
---
A
E
A
L
K
H
P
W
----------
I
SHRSTVASCMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
--------------------------------------------------------------------
576
HHSearch
64.75
40%
-57
- C1 -
-
2BDW
-
KCC2D_CAEEL
B:
[9-306]
-----------------
F
S
D
---
N
Y
D
---
V
K
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
---
T
---
K
K
L
-
S
------
A
R
D
--
F
--
Q
K
--
L
E
R
-
E
A
R
I
C
R
-
K
L
--
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
F
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
AKG
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
N
-
D
-
S
E
-
A
W
H
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
K
-
K
------
D
P
Y
-
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
A
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
---
D
Q
A
L
K
V
P
W
----------
I
-----------
C
------------
N
R
-----------
E
------------
R
VASAIHRQDTV
D
---------------
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
---------------------------------------------------------------------------
8
PsiBlast_PDB
64.56
37%
-64
- C1 -
-
2V7O
3
KCC2G_HUMAN
A:
[29-321]
-----------------
F
T
D
---
D
Y
Q
---
L
F
E
-----
E
L
G
K
G
-
F
S
---
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
H
Q
I
L
E
S
V
N
H
I
H
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
---
C
---
K
GAA
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
---
G
E
-
Q
Q
A
WF
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
K
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
---
D
Q
A
L
K
H
P
W
----------
V
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
E
---------------
C
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------
11
PsiBlast_PDB
64.23
37%
-56
- C1 -
-
2VN9
2
KCC2D_HUMAN
A:
[4-300]
-------------------
D
---
E
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
ASK-
S
---
K
----
G
---
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
--------------------------------------------------------------------------
15
PsiBlast_PDB
64.16
36%
-70
- C1 -
-
3SOA
1
KCC2A_HUMAN
A:
[9-311]
-----------------
F
T
E
---
E
Y
Q
---
L
F
E
-----
E
L
G
K
G
--
S
---
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
---
L
---
K
GAA
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
E
---
G
E
-
Q
Q
A
WF
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
---
A
E
A
L
K
H
P
W
----------
I
SHRSTVASCMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
V
M
L
A
T
R
----------------------------------------------------------------------
31
Blastp_CBE
63.82
38%
-58
- C1 -
-
5VLO
2
KCC2D_HUMAN
B:
[11-300]
-----------------
F
T
D
---
E
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
ASK-
S
---
K
----
G
---
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
-----------------------------------------------------------------------------------
5
PsiBlast_PDB
63.49
36%
-50
- C1 -
-
2BDW
-
KCC2D_CAEEL
A:
[5-311]
------------
S
--
T
K
F
S
D
---
N
Y
D
---
V
K
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
F
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
K
L
Q
--
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
F
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
S
N
G
I
V
H
R
N
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
---
A
---
K
GAA
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
N
-
D
-
S
E
-
A
W
H
--
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
K
-------
K
D
P
Y
-
S
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
A
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
K
K
R
I
T
A
---
D
Q
A
L
K
V
P
W
----------
I
CNRERVASAIH
R
------------
Q
D
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
I
A
T
R
----------------------------------------------------------------------
12
PsiBlast_PDB
63.36
38%
-58
- C1 -
-
5VLO
2
KCC2D_HUMAN
A:
[11-301]
-----------------
F
T
D
---
E
Y
Q
---
L
F
E
-----
E
L
G
---
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
ASK-
S
---
K
----
G
---
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------
6
PsiBlast_PDB
63.26
37%
-66
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[4-306]
-------------------
D
---
E
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
ASK-
S
---
K
----
G
---
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
CQRSMMH----
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
K
G
A
I
L
T
T
M
L
A
T
R
N
F
--------------------------------------------------------------------
27
Blastp_CBE
63.24
38%
-54
- C1 -
-
6BAB
1
KCC2D_MOUSE
D:
[10-301]
------------------
T
D
---
E
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
ASK-
S
---
K
----
G
---
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------
30
Blastp_CBE
63.19
38%
-56
- C1 -
-
6AYW
2
KCC2D_HUMAN
B:
[11-300]
-----------------
F
T
D
---
E
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
ASK-
S
---
K
----
G
---
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
-----------------------------------------------------------------------------------
13
PsiBlast_PDB
63.01
38%
-60
- C1 -
-
6AYW
2
KCC2D_HUMAN
A:
[11-301]
-----------------
F
T
D
---
E
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
ASK-
S
---
K
----
G
---
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------
95
Blastp_CBE
62.42
35%
-68
- C1 -
-
3IGO
8
?
A:
[20-337]
-----------------
F
A
E
---
R
Y
N
---
I
V
C
-----
M
L
G
K
G
S
F
G
---
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
---
K
---
A
S
A
K
N
K
-
T
S
T
I
-------------
L
R
-
E
V
E
L
L
K
-
K
L
D
--
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
-
K
----
R
--
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
E
---
S
KEK-
D
---
C
---
D
---
I
K
I
I
D
F
G
L
S
T
---
C
-
F
-
Q
-
Q
-
N
T
-----------
T
A
Y
Y
I
A
P
E
V
L
R
-
G
T
-------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
-
G
K
N
-----
E
Y
-
D
-------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
---
T
Q
C
L
E
H
P
W
----------
I
-----------
Q
------------
K
Y
-----------
S
------------
S
-----------
E
TPTISDLPSLESAMT
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
------------------------------------------------------------------------
47
Blastp_CBE
62.37
36%
-65
- C1 -
-
3BHH
1
KCC2B_HUMAN
A:
[1-293]
-----------
S
M
--
T
D
E
Y
Q
---
L
Y
E
---
D
--------
I
G
----
S
---
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
---
C
---
K
GAA
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
E
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
K
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
---
H
E
A
L
K
H
P
W
----------
V
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
E
---------------
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------
29
Blastp_CBE
61.61
38%
-53
- C1 -
-
6BAB
2
KCC2D_MOUSE
B:
[14-302]
-----------------------
E
Y
Q
---
L
F
E
-----
E
L
G
----
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
ASK-
S
---
K
----
G
---
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------
421
Blastp_CBE
61.60
34%
-135
- C1 -
-
5TWL
1
MELK_HUMAN
A:
[12-266]
------------------------
Y
E
---
L
H
E
-----
T
I
G
T
G
G
F
A
---
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
---
K
---
N
T
L
G
S
D
L
P
--------
R
--
I
K
--
T
---
E
I
E
A
L
K
-
N
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
Y
---
H
---
K
---
L
K
L
I
D
F
G
L
------------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
Y
L
-
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
K
N
L
L
N
H
P
W
----------
I
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
61.30
34%
-144
- C1 -
-
4BKZ
1
MELK_HUMAN
A:
[12-266]
------------------------
Y
E
---
L
H
E
-----
T
I
G
T
G
--
A
---
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
---
K
---
N
T
L
---
L
P
--------
R
--
I
K
--
T
---
E
I
E
A
L
K
-
N
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
Y
---
H
---
K
---
L
K
L
I
D
F
G
L
-
C
---
A
--------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
K
N
L
L
N
H
P
W
----------
I
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
61.30
38%
-71
- C1 -
-
5VJA
2
DAPK3_HUMAN
C:
[5-272]
-------------------
D
---
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
---
K
---
R
---
R
L
S
S
---
G
V
S
--
R
--
E
E
--
I
E
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
--
E
K
-
E
----
S
--
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
VP--
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
-
A
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
---
A
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
61.17
36%
-125
- C1 -
-
6C9H
2
AAPK1_HUMAN
A:
[20-322]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
T
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
61.09
35%
-132
- C1 -
-
4BFM
1
MELK_MOUSE
A:
[11-265]
------------------------
Y
E
---
L
Y
E
-----
T
I
G
T
G
G
F
A
---
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
---
K
---
N
A
L
G
S
D
L
P
--------
R
--
V
K
--
T
---
E
I
D
A
L
K
-
S
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
N
---
H
---
K
---
L
K
L
I
D
F
G
L
-
C
---
A
-
K
----------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
E
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
R
N
L
L
N
H
P
W
----------
V
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
60.74
36%
-128
- C1 -
-
4REW
1
AAPK1_HUMAN
A:
[12-393]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
T
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
60.60
34%
-141
- C1 -
-
5M5A
1
MELK_HUMAN
A:
[12-266]
------------------------
Y
E
---
L
H
E
-----
T
I
G
T
G
G
F
A
---
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
---
K
---
N
T
L
G
S
D
L
P
--------
R
--
I
K
--
T
---
E
I
E
A
L
K
-
N
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
Y
---
H
---
K
---
L
K
L
I
D
F
G
L
-
C
---
A
--------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
--
L
-
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
K
N
L
L
N
H
P
W
----------
I
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
60.58
35%
-70
- C1 -
-
3NCG
1
?
A:
[20-359]
-----------------
F
A
E
---
R
Y
N
---
I
V
C
-----
M
L
G
K
G
S
F
G
---
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
---
K
---
A
S
A
K
N
K
D
T
S
T
I
-------------
L
R
-
E
V
E
L
L
K
-
K
L
D
--
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
-
K
----
R
--
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
E
---
S
KEK-
D
---
C
---
D
---
I
K
I
I
D
F
G
L
S
T
---
C
-
F
-
Q
-
Q
-
N
T
---------
I
G
T
A
Y
Y
I
A
P
E
V
L
R
-
G
T
-------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
-
G
K
N
-----
E
Y
-
D
-------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
---
T
Q
C
L
E
H
P
W
----------
I
-----------
Q
------------
K
Y
-----------
S
------------
S
-----------
E
TPTISDLPSLESAMT
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
------------------------------------------------------------------------
94
Blastp_CBE
60.57
35%
-67
- C1 -
-
3MWU
1
?
A:
[20-342]
-----------------
F
A
E
---
R
Y
N
---
I
V
C
-----
M
L
G
K
G
S
F
G
---
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
---
K
---
A
S
A
K
N
K
D
T
S
T
I
-------------
L
R
-
E
V
E
L
L
K
-
K
L
D
--
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
-
K
----
R
--
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
E
---
S
KEK-
D
---
C
---
D
---
I
K
I
I
D
F
G
L
S
T
---
C
-
F
-
Q
-
Q
-
N
-------
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
R
-
G
T
-------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
-
G
K
N
-----
E
Y
-
D
-------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
---
T
Q
C
L
E
H
P
W
----------
I
-----------
Q
------------
K
Y
-----------
S
------------
S
-----------
E
TPTISDLPSLESAMT
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
------------------------------------------------------------------------
422
Blastp_CBE
60.53
34%
-133
* C1 *
-
5TVT
1
MELK_HUMAN
A:
[12-266]
------------------------
Y
E
---
L
H
E
-----
T
I
G
T
G
G
F
A
---
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
---
K
---
N
T
L
G
S
D
L
P
--------
R
--
I
K
--
T
---
E
I
E
A
L
K
-
N
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
Y
---
H
---
K
---
L
K
L
I
D
F
G
L
-
C
---
A
-
K
-----------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
Y
L
-
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
K
N
L
L
N
H
P
W
----------
I
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
60.47
35%
-52
- C1 -
-
3LIJ
1
?
A:
[37-340]
-------------------
E
---
M
Y
Q
---
R
V
K
-----
K
L
G
S
---
G
---
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
I
I
R
---
K
--------
S
S
N
S
K
L
-------------
L
E
-
E
V
A
V
L
--
K
L
L
-
D
H
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
-
E
I
I
H
R
-
M
----
K
--
F
N
E
V
D
A
A
V
I
I
K
Q
V
L
S
G
V
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
E
---
S
----
K
---
E
---
K
DAL
I
K
I
V
D
F
G
L
S
A
---
V
-
F
-
E
-
N
-
Q
K
-
K
M
K
--
E
R
-
L
G
T
A
Y
Y
I
A
P
E
V
L
--------
R
K
K
Y
-
D
E
K
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
------
G
-
G
Q
T
-----
D
Q
-
E
-------
I
L
R
K
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
Q
R
R
I
S
A
---
Q
Q
A
L
E
H
P
W
----------
I
-----------
K
------------
E
M
-----------
C
SKKESLPSLANA
I
-----------
E
---------------
N
M
R
K
F
Q
N
S
Q
K
L
A
Q
A
A
L
L
Y
M
A
S
------------------------------------------------------------------------
46
Blastp_CBE
60.45
36%
-68
- C1 -
-
3BHH
1
KCC2B_HUMAN
B:
[2-293]
------------
M
--
T
D
E
Y
Q
---
L
Y
E
---
D
--------
I
G
K
---
S
---
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
---
C
---
K
GAA
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
E
A
Y
-
G
K
P
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
K
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
A
K
R
I
T
A
---
H
E
A
L
K
H
P
W
----------
V
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
E
---------------
C
L
K
K
F
N
A
R
R
K
L
K
---------------------------------------------------------------------------------
92
Blastp_CBE
60.36
35%
-65
- C1 -
-
4Y5Q
1
?
A:
[20-342]
-----------------
F
A
E
---
R
Y
N
---
I
V
C
-----
M
L
G
K
G
S
F
G
---
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
---
K
---
A
S
A
K
N
K
D
T
S
T
I
-------------
L
R
-
E
V
E
L
L
K
-
K
L
D
--
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
-
K
----
R
--
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
E
---
S
KEK-
D
---
C
---
D
---
I
K
I
I
D
F
G
L
S
T
---
C
-
F
-
Q
-
Q
-
N
T
------
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
R
-
G
T
-------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
-
G
K
N
-----
E
Y
-
D
-------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
---
T
Q
C
L
E
H
P
W
----------
I
-----------
Q
------------
K
Y
-----------
S
------------
S
-----------
E
TPTISDLPSLESAMT
N
I
R
Q
F
Q
A
E
K
K
L
A
Q
A
A
L
L
Y
M
A
S
------------------------------------------------------------------------
124
Blastp_CBE
60.24
36%
-21
- C1 -
-
3MFS
1
CSKP_HUMAN
A:
[22-320]
-----------------
F
E
D
---
V
Y
E
---
L
C
E
-----
V
I
G
K
G
A
F
S
---
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
AKF
T
S
S
P
G
L
S
T
E
D
L
K
----
R
--
E
A
--
S
I
---
C
H
M
L
K
------
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
R
-
A
DAGF
V
--
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
-
L
---
L
----
A
---
S
----
K
---
E
---
N
SAP
V
K
L
G
D
F
G
V
A
I
---
Q
-
L
G
E
-
S
-
G
L
-
V
A
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
-
G
T
K
-----
E
R
-
L
--------
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
---
Y
E
A
L
N
H
P
W
----------
L
-----------
K
------------
E
R
DRYAYKIHLPE
T
------------
V
-----------
E
---------------
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------
14
PsiBlast_PDB
60.12
38%
-49
- C1 -
-
6BAB
2
KCC2D_MOUSE
A:
[12-301]
------------------
T
D
---
E
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
ASK-
S
---
K
----
G
---
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------
96
Blastp_CBE
59.89
38%
-71
- C1 -
-
5VJA
3
DAPK3_HUMAN
D:
[5-271]
-------------------
D
---
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
---
K
---
R
---
R
L
S
-----
V
S
--
R
--
E
E
--
I
E
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
----
E
K
-
E
----
S
--
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
VP--
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
-
A
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
---
A
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
59.67
36%
-20
- C1 -
-
3MFU
1
CSKP_HUMAN
A:
[22-320]
-----------------
F
E
D
---
V
Y
E
---
L
C
E
-----
V
I
G
K
G
A
F
S
---
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
AKF
T
S
S
P
G
L
S
T
E
D
L
K
----
R
--
E
A
--
S
I
---
C
H
M
L
K
------
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
R
-
A
DAGF
V
--
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
-
L
---
L
----
A
---
S
----
K
---
E
---
N
SAP
V
K
L
G
D
F
G
V
A
I
---
Q
-
L
G
E
-
S
-
G
L
-
V
A
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
-
G
T
K
-----
E
R
-
L
--------
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
---
Y
E
A
L
N
H
P
W
----------
L
-----------
K
------------
E
R
DRYAYKIHLPE
T
------------
V
-----------
E
---------------
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------
17
PsiBlast_PDB
59.57
38%
-68
- C1 -
-
5FG8
3
KCC2A_DROME
A:
[12-276]
-----------------
F
S
D
---
N
Y
D
---
I
K
E
-----
E
L
G
K
G
A
F
S
---
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
---
T
---
K
---
K
L
T
A
R
D
F
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
K
L
H
--
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
F
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
---
A
---
K
GAA
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
H
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
E
P
-
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
---
A
E
A
L
K
H
P
W
----------
I
-----------
C
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
59.48
35%
-130
- C1 -
-
4CQG
1
MELK_MOUSE
A:
[11-265]
------------------------
Y
E
---
L
Y
E
-----
T
I
G
T
G
G
F
A
---
K
V
K
L
A
C
H
V
L
T
G
E
M
V
A
I
K
I
M
D
---
K
---
N
A
L
G
S
D
L
P
--------
R
--
V
K
--
T
---
E
I
D
A
L
K
-
S
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
N
---
H
---
K
---
L
K
L
I
D
F
G
L
-
C
---
A
-
K
----------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
------
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
E
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
R
N
L
L
N
H
P
W
----------
V
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
59.48
39%
-51
- C1 -
-
2CKE
1
DAPK2_HUMAN
B:
[10-275]
------------
V
--
E
D
F
Y
D
---
I
G
E
---
E
--------
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
---
K
---
R
Q
S
R
A
-
S
R
R
G
V
S
----
R
--
E
E
--
I
E
R
-
E
V
S
I
L
R
-
Q
V
L
--
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
-
E
----
S
--
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
K
----
N
---
I
PIP
H
---
I
K
L
I
D
F
G
L
A
H
---
E
-
I
-
E
-
D
-
G
V
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
---
Q
E
A
L
R
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
59.48
39%
-48
- C1 -
-
2CKE
1
DAPK2_HUMAN
C:
[10-275]
------------
V
--
E
D
F
Y
D
---
I
G
E
---
E
--------
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
---
K
---
R
Q
S
R
A
-
S
R
R
G
V
S
----
R
--
E
E
--
I
E
R
-
E
V
S
I
L
R
-
Q
V
L
--
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
-
E
----
S
--
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
K
----
N
---
I
PIP
H
---
I
K
L
I
D
F
G
L
A
H
---
E
-
I
-
E
-
D
-
G
V
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
---
Q
E
A
L
R
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
59.42
34%
-138
- C1 -
-
5MAH
2
MELK_HUMAN
A:
[12-266]
------------------------
Y
E
---
L
H
E
-----
T
I
G
T
G
G
F
A
---
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
---
K
---
N
T
L
G
S
D
L
P
--------
R
--
I
K
--
T
---
E
I
E
A
L
K
-
N
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
Y
---
H
---
K
---
L
K
L
I
D
F
G
L
-
C
---
A
-
K
------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
--
L
-
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
K
N
L
L
N
H
P
W
----------
I
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
59.39
35%
-25
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[22-317]
-----------------
F
E
D
---
V
Y
E
---
L
C
E
-----
V
I
G
K
G
P
F
S
---
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
AKF
T
S
S
P
G
L
S
T
E
D
L
K
----
R
--
E
A
--
S
I
---
C
H
M
L
K
------
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
R
-
A
DAGF
V
--
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
----
A
---
S
----
K
---
E
---
N
SAP
V
K
L
G
G
F
G
V
A
I
---
Q
-
L
G
E
-
S
-
G
L
-
V
A
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
-
G
T
K
-----
E
R
-
L
--------
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
---
Y
E
A
L
N
H
P
W
----------
L
-----------
K
------------
E
R
DRYAYKIHLPE
T
------------
V
-----------
E
---------------
Q
L
R
K
F
N
A
R
R
K
-----------------------------------------------------------------------------------
208
Blastp_CBE
59.24
39%
-46
- C1 -
-
2CKE
1
DAPK2_HUMAN
A:
[10-275]
------------
V
--
E
D
F
Y
D
---
I
G
E
---
E
--------
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
---
K
---
R
Q
S
R
A
-
S
R
R
G
V
S
----
R
--
E
E
--
I
E
R
-
E
V
S
I
L
R
-
Q
V
L
--
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
-
E
----
S
--
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
K
----
N
---
I
PIP
H
---
I
K
L
I
D
F
G
L
A
H
---
E
-
I
-
E
-
D
-
G
V
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
---
Q
E
A
L
R
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
59.14
35%
-31
- C1 -
-
3C0G
1
CSKP_HUMAN
A:
[22-334]
-----------------
F
E
D
---
V
Y
E
---
L
C
E
-----
V
I
G
K
G
P
F
S
---
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
AKF
T
S
S
P
G
L
S
T
E
D
L
K
----
R
--
E
A
--
S
I
---
C
H
M
L
K
------
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
R
-
A
DAGF
V
--
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
----
A
---
S
----
K
---
E
---
N
SAP
V
K
L
G
G
F
G
V
A
I
---
Q
-
L
G
E
-
S
-
G
L
-
V
A
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
-
G
T
K
-----
E
R
-
L
--------
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
---
Y
E
A
L
N
H
P
W
----------
L
-----------
K
------------
E
R
DRYAYKIHLPE
T
------------
V
-----------
E
---------------
Q
L
R
K
F
N
A
R
R
K
L
K
--
V
L
A
A
V
S
S
------------------------------------------------------------------------
28
Blastp_CBE
59.11
38%
-53
- C1 -
-
6BAB
3
KCC2D_MOUSE
C:
[14-301]
-----------------------
E
Y
Q
---
L
F
E
-----
E
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
I
I
N
---
T
---
K
---
K
L
S
A
R
D
H
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
L
L
K
--
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
Y
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
ASK-
S
---
K
----
G
---
A
---
A
---
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
Q
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
R
-------
K
D
P
Y
-
G
K
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
Q
Q
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
I
T
A
---
S
E
A
L
K
H
P
W
----------
I
CQRSTVASMMH
R
------------
Q
E
-----------
T
------------
V
-----------
D
---------------
C
L
K
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------
125
Blastp_CBE
58.75
36%
-16
- C1 -
-
3MFR
1
CSKP_HUMAN
A:
[22-320]
-----------------
F
E
D
---
V
Y
E
---
L
C
E
-----
V
I
G
K
G
A
F
S
---
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
AKF
T
S
S
P
G
L
S
T
E
D
L
K
----
R
--
E
A
--
S
I
---
C
H
M
L
K
------
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
R
-
A
DAGF
V
--
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
E
N
V
-
L
---
L
----
A
---
S
----
K
---
E
---
N
SAP
V
K
L
G
D
F
G
V
A
I
---
Q
-
L
G
E
-
S
-
G
L
-
V
A
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
-
G
T
K
-----
E
R
-
L
--------
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
---
Y
E
A
L
N
H
P
W
----------
L
-----------
K
------------
E
R
DRYAYKIHLPE
T
------------
V
-----------
E
---------------
Q
L
R
K
F
N
A
R
R
K
L
K
G
--------------------------------------------------------------------------------
227
Blastp_CBE
58.71
35%
-33
- C1 -
-
3C0H
1
CSKP_HUMAN
B:
[22-318]
-----------------
F
E
D
---
V
Y
E
---
L
C
E
-----
V
I
G
K
G
P
F
S
---
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
AKF
T
S
S
P
G
L
S
T
E
D
L
K
----
R
--
E
A
--
S
I
---
C
H
M
L
K
------
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
R
-
A
DAGF
V
--
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
----
A
---
S
----
K
---
E
---
N
SAP
V
K
L
G
G
F
G
V
A
I
---
Q
-
L
G
E
-
S
-
G
L
-
V
A
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
-
G
T
K
-----
E
R
-
L
--------
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
---
Y
E
A
L
N
H
P
W
----------
L
-----------
K
------------
E
R
DRYAYKIHLPE
T
------------
V
-----------
E
---------------
Q
L
R
K
F
N
A
R
R
K
L
----------------------------------------------------------------------------------
142
Blastp_CBE
58.68
38%
-47
- C1 -
-
1WVY
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
58.47
39%
-47
- C1 -
-
2CKE
1
DAPK2_HUMAN
D:
[10-275]
------------
V
--
E
D
F
Y
D
---
I
G
E
---
E
--------
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
---
K
---
R
Q
S
R
A
-
S
R
R
G
V
S
----
R
--
E
E
--
I
E
R
-
E
V
S
I
L
R
-
Q
V
L
--
H
H
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
-
E
----
S
--
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
K
----
N
---
I
PIP
H
---
I
K
L
I
D
F
G
L
A
H
---
E
-
I
-
E
-
D
-
G
V
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
---
Q
E
A
L
R
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
58.45
34%
-129
- C1 -
-
6GVX
2
MELK_HUMAN
B:
[15-269]
------------------------
Y
E
---
L
H
E
-----
T
I
G
T
G
--
A
---
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
---
K
---
N
T
--
S
D
L
P
--------
R
--
I
K
--
T
---
E
I
E
A
L
K
-
N
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
Y
---
H
---
K
---
L
K
L
I
D
F
G
L
-
C
---
A
-
K
-
P
---------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
G
-----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
K
N
L
L
N
H
P
W
----------
I
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
58.46
34%
-137
- C1 -
-
4BKY
1
MELK_HUMAN
A:
[12-266]
------------------------
Y
E
---
L
H
E
-----
T
I
G
T
G
G
F
A
---
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
---
K
---
N
T
L
--
D
L
P
--------
R
--
I
K
--
T
---
E
I
E
A
L
K
-
N
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
Y
---
H
---
K
---
L
K
L
I
D
F
G
L
-
C
---
A
--------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
----
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
K
N
L
L
N
H
P
W
----------
I
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
58.45
38%
-64
- C1 -
-
5H9B
2
KCC2A_DROME
A:
[12-276]
-----------------
F
S
D
---
N
Y
D
---
I
K
E
-----
E
L
G
K
G
A
F
S
---
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
---
T
---
K
---
K
L
T
A
R
D
F
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
K
L
H
--
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
F
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
---
A
---
K
GAA
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
H
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
E
P
-
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
---
A
E
A
L
K
H
P
W
----------
I
-----------
C
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
58.33
38%
-68
- C1 -
-
5HU3
1
KCC2A_DROME
A:
[12-274]
-----------------
F
S
D
---
N
Y
D
---
I
K
E
-----
E
L
G
K
G
A
F
S
---
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
N
---
T
---
K
---
K
L
T
A
R
D
F
Q
K
L
--
E
--------
R
-
E
A
R
I
C
R
-
K
L
H
--
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
-
E
----
F
--
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
N
G
V
V
H
R
N
L
K
P
E
N
L
-
L
---
L
----
A
---
S
----
K
---
A
---
K
GAA
V
K
L
A
D
F
G
L
A
I
---
E
-
V
-
Q
-
G
-
D
H
-
Q
A
W
F-
G
F
-
A
G
T
P
G
Y
L
S
P
E
V
L
K
------
K
E
P
-
Y
-
G
K
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
------
W
-
D
E
D
-----
Q
H
-
R
-------
L
Y
S
Q
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
I
T
A
---
A
E
A
L
K
H
P
W
----------
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
58.17
38%
-47
- C1 -
-
6FHB
2
DAPK1_HUMAN
A:
[16-279]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
58.14
34%
-139
- C1 -
-
5MAG
3
MELK_HUMAN
A:
[12-266]
------------------------
Y
E
---
L
H
E
-----
T
I
G
T
G
G
-
A
---
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
---
K
---
N
T
L
--
D
L
P
--------
R
--
I
K
--
T
---
E
I
E
A
L
K
-
N
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
Y
---
H
---
K
---
L
K
L
I
D
F
G
L
-
C
---
A
-
K
------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
--
L
-
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
K
N
L
L
N
H
P
W
----------
I
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
58.14
38%
-52
- C1 -
-
2Y0A
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
57.97
35%
-27
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[22-328]
-----------------
F
E
D
---
V
Y
E
---
L
C
E
-----
V
I
G
K
G
P
F
S
---
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
AKF
T
S
S
P
G
L
S
T
E
D
L
K
----
R
--
E
A
--
S
I
---
C
H
M
L
K
------
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
R
-
A
DAGF
V
--
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
----
A
---
S
----
K
---
E
---
N
SAP
V
K
L
G
G
F
G
V
A
I
---
Q
-
L
G
E
-
S
-
G
L
-
V
A
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-------
R
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
-
G
T
K
-----
E
R
-
L
--------
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
---
Y
E
A
L
N
H
P
W
----------
L
-----------
K
------------
E
R
DRYAYKIHLPE
T
------------
V
-----------
E
---------------
Q
L
R
K
F
N
A
R
R
K
L
K
G
A
V
L
A
A
V
S
S
------------------------------------------------------------------------
435
Blastp_CBE
57.95
34%
-134
- C1 -
-
5MAF
2
MELK_HUMAN
A:
[12-266]
------------------------
Y
E
---
L
H
E
-----
T
I
G
T
G
G
F
A
---
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
---
K
---
N
T
L
--
D
L
P
--------
R
--
I
K
--
T
---
E
I
E
A
L
K
-
N
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
Y
---
H
---
K
---
L
K
L
I
D
F
G
L
-
C
---
A
-
K
------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
--
L
-
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
K
N
L
L
N
H
P
W
----------
I
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
57.86
37%
-36
- C1 -
-
3HX4
3
?
A:
[43-317]
----------
H
S
T
--
A
I
F
S
D
---
R
Y
K
---
G
Q
R
-----
V
L
G
K
G
S
F
G
---
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------------
S
K
------D-
K
--
E
S
--
L
L
R
-
E
V
Q
L
L
K
-
Q
L
D
--
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
-
K
----
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
E
---
S
KSK-
D
---
A
---
N
---
I
R
I
I
D
F
G
L
S
T
---
H
-
F
-
E
-
A
-
S
K
-
K
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
-
G
A
N
-----
E
Y
-
D
-------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
---
R
D
A
L
D
H
E
W
----------
I
-----------
Q
------------
T
Y
-----------
T
------------
K
-----------
E
---------------
Q
I
-------------------------------------------------------------------------------------------
139
Blastp_CBE
57.52
38%
-53
- C1 -
-
2YAK
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
57.47
38%
-48
- C1 -
-
4TXC
7
DAPK1_HUMAN
A:
[32-295]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
57.46
38%
-75
- C1 -
-
5JZN
1
B:
[19-277]
-------------------
E
---
R
Y
K
---
V
G
R
-----
T
I
G
D
G
N
F
A
---
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--------------
K
K
S
K
C
R
G
K
--
E
--
H
M
--
I
Q
N
-
E
V
S
I
L
R
-
R
V
K
--
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
-
A
I
T
S
T
-
N
----
K
--
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
-
L
---
V
YEHQ
D
---
G
----
S
---
K
---
S
---
L
K
L
G
D
F
G
L
A
T
---
I
-
V
-
D
-
G
----
P
L
Y
--
T
V
-
C
G
T
P
T
Y
V
A
P
E
I
I
A
-------
E
T
G
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
-
G
S
------
Q
E
-
V
-------
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
---
V
Q
V
L
E
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
57.37
38%
-61
- C1 -
-
5A6N
1
DAPK3_HUMAN
B:
[5-272]
-------------------
D
---
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
---
K
---
R
---
R
L
S
S
S
R
R
G
V
S
--
R
--
E
E
--
I
E
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
KNVP
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
--------
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
---
A
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
57.25
38%
-56
- C1 -
-
5VJA
2
DAPK3_HUMAN
B:
[5-272]
-------------------
D
---
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
---
K
---
R
---------
R
G
V
S
--
R
--
E
E
--
I
E
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
KNVP
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
-
A
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
---
A
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
57.22
38%
-47
- C1 -
-
6QMO
7
DAPK1_HUMAN
A:
[16-279]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
57.19
38%
-48
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[15-278]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
57.19
38%
-67
- C1 -
-
5JZN
1
DCLK1_HUMAN
A:
[19-277]
-------------------
E
---
R
Y
K
---
V
G
R
-----
T
I
G
D
G
N
F
A
---
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--------------
K
K
S
K
C
R
G
K
--
E
--
H
M
--
I
Q
N
-
E
V
S
I
L
R
-
R
V
K
--
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
-
A
I
T
S
T
-
N
----
K
--
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
-
L
---
V
YEHQ
D
---
G
----
S
---
K
---
S
---
L
K
L
G
D
F
G
L
A
T
---
I
-
V
-
D
-
G
----
P
L
Y
--
T
V
-
C
G
T
P
T
Y
V
A
P
E
I
I
A
-------
E
T
G
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
-
G
S
D
-----
Q
E
-
V
-------
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
---
V
Q
V
L
E
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
56.87
37%
-63
- C1 -
-
2WEI
1
?
A:
[20-286]
-----------------
F
A
E
---
R
Y
N
---
I
V
C
-----
M
L
G
K
G
S
F
G
---
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
V
I
N
---
K
---
A
S
A
K
N
K
D
T
S
T
I
-------------
L
R
-
E
V
E
L
L
K
-
K
L
D
--
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
-
E
I
I
K
R
-
K
----
R
--
F
S
E
H
D
A
A
R
I
I
K
Q
V
F
S
G
I
T
Y
M
H
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
---
L
----
E
---
S
KEK-
D
---
C
---
D
---
I
K
I
I
D
F
G
L
S
T
---
C
-
F
-
Q
-
Q
-
N
T
-
K
M
K
--
D
R
-
I
G
T
A
Y
Y
I
A
P
E
V
L
R
-
G
T
-------
Y
-
D
E
K
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
------
Y
-
G
K
N
-----
E
Y
-
D
-------
I
L
K
R
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
S
L
R
I
T
A
---
T
Q
C
L
E
H
P
W
----------
I
-----------
Q
------------
K
Y
-----------
S
------------
S
-----------
E
------------------------------------------------------------------------------------------------------------
100
Blastp_CBE
56.73
38%
-56
- C1 -
-
5A6O
2
DAPK3_HUMAN
B:
[5-271]
-------------------
D
---
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
---
K
---
R
---
R
L
S
S
S
R
R
G
V
S
--
R
--
E
E
--
I
E
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
KNVP
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
--------
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
---
A
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
56.72
38%
-43
- C1 -
-
5AV2
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
------
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
56.71
38%
-76
- C1 -
-
5JZJ
2
DCLK1_HUMAN
A:
[36-294]
-------------------
E
---
R
Y
K
---
V
G
R
-----
T
I
G
D
G
N
F
A
---
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--------------
K
K
S
K
C
R
G
K
--
E
--
H
M
--
I
Q
N
-
E
V
S
I
L
R
-
R
V
K
--
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
-
A
I
T
S
T
-
N
----
K
--
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
-
L
---
V
YEHQ
D
---
G
----
S
---
K
---
S
---
L
K
L
G
D
F
G
L
A
T
---
I
-
V
-
D
-
G
----
P
L
Y
--
T
V
-
C
G
T
P
T
Y
V
A
P
E
I
I
A
-------
E
T
G
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
-
G
S
-------
E
-
V
-------
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
---
V
Q
V
L
E
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
56.70
38%
-82
- C1 -
-
5JZJ
1
B:
[36-294]
-------------------
E
---
R
Y
K
---
V
G
R
-----
T
I
G
D
G
N
F
A
---
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
I
I
--------------
K
K
S
K
C
R
G
K
--
E
--
H
M
--
I
Q
N
-
E
V
S
I
L
R
-
R
V
K
--
H
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
-
A
I
T
S
T
-
N
----
K
--
Y
T
E
R
D
A
S
G
M
L
Y
N
L
A
S
A
I
K
Y
L
H
S
L
N
I
V
H
R
D
I
K
P
E
N
L
-
L
---
V
YEHQ
D
---
G
----
S
---
K
---
S
---
L
K
L
G
D
F
G
L
A
T
---
I
-
V
-
D
-
G
----
P
L
Y
--
T
V
-
C
G
T
P
T
Y
V
A
P
E
I
I
A
-------
E
T
G
Y
-
G
L
K
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
------
R
----------
E
-
V
-------
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
D
Q
R
F
S
A
---
V
Q
V
L
E
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
56.62
38%
-51
- C1 -
-
2XUU
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
A
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
56.52
35%
-56
- C1 -
-
3F3Z
5
?
A:
[6-276]
----------------
D
I
N
Q
---
Y
Y
T
---
L
E
N
-----
T
I
G
R
G
S
W
G
---
E
V
K
I
A
V
Q
K
G
T
R
I
R
R
A
A
K
K
I
P
-----------
K
Y
F
V
E
D
V
D
R
F
--
K
--
Q
-------
E
I
E
I
M
K
-
S
L
D
--
H
P
N
I
I
R
L
Y
E
T
F
E
D
N
T
D
I
Y
L
V
M
E
L
C
T
G
G
E
L
F
E
-
R
V
V
H
K
-
R
----
V
--
F
R
E
S
D
A
A
R
I
M
K
D
V
L
S
A
V
A
Y
C
H
K
L
N
V
A
H
R
D
L
K
P
E
N
F
-
L
F--
L
----
T
---
D
----
S
---
P
---
D
SP-
L
K
L
I
D
F
G
L
A
A
---
R
-
F
-
K
-
P
-
G
K
-
M
M
R
--
T
K
-
V
G
T
P
Y
Y
V
S
P
Q
V
L
E
-
G
L
-------
Y
-
G
P
E
C
D
E
W
S
A
G
V
M
M
Y
V
L
L
C
G
Y
P
P
F
------
S
-
A
P
T
-----
D
E
-
V
-------
M
L
K
-
I
R
E
G
T
F
T
F
P
E
K
D
W
L
N
V
S
P
Q
A
E
S
L
I
R
R
L
L
T
K
S
P
K
Q
R
I
T
S
---
L
Q
A
L
E
H
E
W
----------
F
-----------
E
------------
K
Q
-----------
L
------------
S
-----------
S
---------------
S
P
R
N
L
----------------------------------------------------------------------------------------
265
Blastp_CBE
56.52
37%
-65
- C1 -
-
3Q5I
1
?
A:
[36-310]
-------------------
E
---
S
Y
F
---
K
V
R
-----
K
L
G
S
--
Y
G
---
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
V
I
K
---
K
---------------
K
F
--
H
--
E
E
--
I
Y
N
-
E
I
S
L
L
K
-
S
L
D
--
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
-
Q
I
I
N
R
-
H
----
K
--
F
D
E
C
D
A
A
N
I
M
K
Q
I
L
S
G
I
C
Y
L
H
K
H
N
I
V
H
R
D
I
K
P
E
N
I
-
L
---
L
----
E
---
N
----
K
NSL
L
---
N
---
I
K
I
V
D
F
G
L
S
S
---
F
-
F
-
S
-
K
-
D
Y
-
K
L
R
--
D
R
-
L
G
T
A
Y
Y
I
A
P
E
V
L
K
-
K
K
Y
N
E
--------
K
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
------
G
-
G
Q
N
-----
D
Q
-
D
-------
I
I
K
K
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
N
K
R
C
T
A
---
E
E
A
L
N
S
R
W
----------
I
-----------
K
------------
K
Y
-------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
56.52
38%
-47
- C1 -
-
4UV0
1
DAPK1_HUMAN
A:
[15-278]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
56.52
38%
-52
- C1 -
-
3BHY
1
DAPK3_HUMAN
A:
[5-277]
-------------------
D
---
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
---
K
---
R
---
R
L
S
S
S
R
R
G
V
S
--
R
--
E
E
--
I
E
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
KNVP
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
--------------
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
---
A
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
I
-----------
R
------------
R
-----------
R
---------------
N
V
-------------------------------------------------------------------------------------------
271
Blastp_CBE
56.51
37%
-108
- C1 -
-
5EAK
1
MARK2_HUMAN
A:
[11-263]
---------------
Q
P
H
I
G
---
N
Y
R
---
L
L
K
-----
T
I
G
K
G
N
F
A
---
K
V
K
L
A
R
H
I
L
T
G
K
E
V
A
V
K
I
I
D
---
K
---
T
Q
L
N
S
S
S
L
Q
K
L
-------------
F
R
-
E
V
R
I
M
--
K
V
L
-
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
-
Y
L
V
A
H
-
G
----
R
--
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
F
I
V
H
R
D
L
K
A
E
N
L
-
L
---
L
----
D
---
A
----
D
---
M
---
N
---
I
K
I
A
D
F
G
F
S
---------------------
F
-
C
G
S
P
P
Y
A
A
P
E
L
F
Q
-
G
K
K
Y
D
------
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
------
D
-
G
Q
N
-----
L
K
-
E
-------
L
R
E
R
V
L
R
G
K
Y
R
I
--
P
F
Y
--
M
S
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
G
T
L
---
E
Q
I
M
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
56.41
38%
-44
- C1 -
-
5AUZ
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
56.36
38%
-56
- C1 -
-
5A6O
3
DAPK3_HUMAN
A:
[5-272]
-------------------
D
---
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
---
K
---
R
---
R
L
S
S
S
R
R
G
V
S
--
R
--
E
E
--
I
E
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
KNVP
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
--------
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
---
A
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
56.34
38%
-45
- C1 -
-
2W4K
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
56.31
38%
-42
- C1 -
-
5AV3
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
------
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
56.25
38%
-45
- C1 -
-
5AV0
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
------
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
578
HHSearch
56.23
36%
-46
- C1 -
-
3C0I
1
CSKP_HUMAN
A:
[20-294]
---------------
V
L
F
E
D
---
V
Y
E
---
L
C
E
-----
V
I
G
K
G
P
F
S
---
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
---
A
K
F
T
S
----
S
P
G
L
S
--
T
--
E
D
--
L
K
R
-
E
A
S
I
C
H
-
M
L
--
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
R
-
A
DAGF
V
--
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
----
A
---
S
----
K
ENS
A
---
P
---
V
K
L
G
G
F
G
V
A
I
---
Q
-
L
-
G
-
E
-
S
G
L
V
A
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-
R
------
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
-
G
T
K
-----
E
--
R
-------
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
---
Y
E
A
L
N
H
P
W
----------
L
-----------
K
------------
E
R
-----------
D
-------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
56.21
38%
-42
- C1 -
-
6QN4
4
DAPK1_HUMAN
A:
[16-279]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
56.20
38%
-41
- C1 -
-
5AUX
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
------
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
56.16
38%
-46
- C1 -
-
5AUW
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
---------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
56.15
38%
-42
- C1 -
-
4PF4
6
DAPK1_HUMAN
A:
[14-277]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
99
Blastp_CBE
56.11
38%
-50
- C1 -
-
5VJA
2
DAPK3_HUMAN
A:
[5-271]
-------------------
D
---
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
---
K
---
R
--------
R
R
G
V
S
--
R
--
E
E
--
I
E
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
KNVP
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
-
A
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
---
A
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
--------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
56.05
38%
-43
- C1 -
-
5AUU
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
56.04
38%
-42
- C1 -
-
2W4J
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
56.01
38%
-41
- C1 -
-
5AUV
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
------
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
582
HHSearch
55.94
41%
-71
- C1 -
-
2W4O
1
KCC4_HUMAN
A:
[49-346]
---------------
D
A
L
S
D
---
F
F
E
---
V
E
S
-----
E
L
G
R
G
A
T
S
---
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
---
K
-------------------------------
I
G
V
L
L
-
R
L
--
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
-
R
I
V
E
K
-
G
----
Y
--
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
----
A
TPA
P
----
D
---
A
---
P
---
L
K
I
A
D
F
---------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
-
G
------
C
A
Y
-
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
------
Y
-
D
E
R
-----
G
D
Q
F
-------
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
---
F
Q
A
L
Q
H
P
W
----------
V
-----------
T
------------
G
K
-----------
A
------------
A
-----------
N
FVHMDTAQK------
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
-----------------------------------------------------------------------
41
Blastp_CBE
55.94
37%
-67
- C1 -
-
2W4O
1
KCC4_HUMAN
A:
[44-346]
--------
D
G
S
N
R
--
D
A
L
S
D
---
F
F
E
---
V
E
S
-----
E
L
G
R
G
A
T
S
---
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
V
L
K
---
K
-------------------------------
I
G
V
L
L
-
R
L
S
--
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
-
R
I
V
E
K
-
G
----
Y
--
Y
S
E
R
D
A
A
D
A
V
K
Q
I
L
E
A
V
A
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
----
A
---
T
PAP-
D
---
A
---
P
---
L
K
I
A
D
F
---------------------------
G
T
P
G
Y
C
A
P
E
I
L
R
G
C
A
-------
Y
-
G
P
E
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
------
Y
D
E
R
G
-----
D
Q
-
F
-------
M
F
R
R
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
K
K
R
L
T
T
---
F
Q
A
L
Q
H
P
W
----------
V
-----------
T
------------
G
K
-----------
A
------------
A
NFVHMDTAQ--
K
---------------
K
L
Q
E
F
N
A
R
R
K
L
K
A
A
V
K
A
V
V
A
S
S
-----------------------------------------------------------------------
153
Blastp_CBE
55.90
38%
-41
- C1 -
-
5AUY
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
------
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
55.67
38%
-59
- C1 -
-
4D9U
1
A:
[20-284]
-----------------
F
T
D
---
G
Y
E
---
V
K
E
-----
D
I
G
V
G
S
Y
S
---
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
------------------
K
S
K
--
R
--
D
P
--
T
-
E
-
E
I
E
I
L
L
-
R
Y
G
-
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
-
K
I
L
R
Q
-
K
----
F
--
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y--
V
----
D
---
E
----
S
---
G
---
N
PES
I
R
I
C
D
F
G
F
A
K
---
Q
-
L
-
R
-
A
-
E
N
-
G
L
L
--
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
-
N
G
P
-----
D
D
-
T
PEE----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
---
A
L
V
L
R
H
P
W
----------
I
-----------
V
------------
H
W
-------------------------------------------------------------------------------------------------------------------------------------------------
577
HHSearch
55.42
36%
-48
- C1 -
-
3C0G
1
CSKP_HUMAN
B:
[19-294]
------------
D
--
V
L
F
E
D
---
V
Y
E
---
L
C
E
-----
V
I
G
K
G
P
F
S
---
V
V
R
R
C
I
N
R
E
T
G
Q
Q
F
A
V
K
I
V
D
---
V
---
A
K
F
T
S
----
S
P
G
L
S
--
T
--
E
D
--
L
K
R
-
E
A
S
I
C
H
-
M
L
--
K
H
P
H
I
V
E
L
L
E
T
Y
S
S
D
G
M
L
Y
M
V
F
E
F
M
D
G
A
D
L
C
F
-
E
I
V
K
R
-
A
DAGF
V
--
Y
S
E
A
V
A
S
H
Y
M
R
Q
I
L
E
A
L
R
Y
C
H
D
N
N
I
I
H
R
D
V
K
P
H
C
V
-
L
---
L
----
A
---
S
----
K
ENS
A
---
P
---
V
K
L
G
G
F
G
V
A
I
---
Q
-
L
-
G
-
E
-
S
G
L
V
A
G
--
G
R
-
V
G
T
P
H
F
M
A
P
E
V
V
K
-
R
------
E
P
Y
-
G
K
P
V
D
V
W
G
C
G
V
I
L
F
I
L
L
S
G
C
L
P
F
------
Y
-
G
T
K
-----
E
--
R
-------
L
F
E
G
I
I
K
G
K
Y
K
M
N
P
R
Q
W
S
H
I
S
E
S
A
K
D
L
V
R
R
M
L
M
L
D
P
A
E
R
I
T
V
---
Y
E
A
L
N
H
P
W
----------
L
-----------
K
------------
E
R
-----------
D
-------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
55.40
38%
-58
- C1 -
-
4D9T
1
A:
[20-284]
-----------------
F
T
D
---
G
Y
E
---
V
K
E
-----
D
I
G
V
G
S
Y
S
---
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
------------------
K
S
K
--
R
--
D
P
--
T
-
E
-
E
I
E
I
L
L
-
R
Y
G
-
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
-
K
I
L
R
Q
-
K
----
F
--
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y--
V
----
D
---
E
----
S
---
G
---
N
PES
I
R
I
C
D
F
G
F
A
K
---
Q
-
L
-
R
-
A
-
E
N
-
G
L
L
--
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
-
N
G
P
-----
D
D
-
T
PEE----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
---
A
L
V
L
R
H
P
W
----------
I
-----------
V
------------
H
W
-------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
55.36
38%
-45
- C1 -
-
5AV4
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
55.07
39%
-44
- C1 -
-
2YAA
1
DAPK2_MOUSE
B:
[8-275]
----------
Q
K
V
--
E
D
F
Y
D
---
I
G
E
---
E
--------
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
---
K
---
R
Q
S
R
A
S
R
R
G
V
C
R
E
E
--
I
--
E
-----
R
-
E
V
S
I
L
R
-
Q
V
L
--
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
-
E
----
S
--
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
K
----
N
---
I
PIP
H
---
I
K
L
I
D
F
G
L
A
H
---
E
-
I
-
E
-
D
-
G
V
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
---
Q
E
A
L
R
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
54.96
39%
-45
- C1 -
-
2YAA
1
DAPK2_MOUSE
A:
[8-275]
----------
Q
K
V
--
E
D
F
Y
D
---
I
G
E
---
E
--------
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
---
K
---
R
Q
S
R
A
S
R
R
G
V
C
R
E
E
--
I
--
E
-----
R
-
E
V
S
I
L
R
-
Q
V
L
--
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
Q
K
-
E
----
S
--
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
K
----
N
---
I
PIP
H
---
I
K
L
I
D
F
G
L
A
H
---
E
-
I
-
E
-
D
-
G
V
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
---
Q
E
A
L
R
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
54.94
38%
-48
- C1 -
-
5A6N
4
DAPK3_HUMAN
A:
[5-272]
-------------------
D
---
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
---
K
---
R
---
R
L
S
S
S
R
R
G
V
S
--
R
--
E
E
--
I
E
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
KNVP
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
-
A
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
---
A
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
I
-------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
54.88
38%
-41
- C1 -
-
5AUT
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
---
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
54.84
38%
-59
- C1 -
-
4JG8
1
A:
[33-297]
-----------------
F
T
D
---
G
Y
E
---
V
K
E
-----
D
I
G
V
G
S
Y
S
---
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
------------------
K
S
K
--
R
--
D
P
--
T
-
E
-
E
I
E
I
L
L
-
R
Y
G
-
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
M
E
L
M
K
G
G
E
L
L
D
-
K
I
L
R
Q
-
K
----
F
--
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y--
V
----
D
---
E
----
S
---
G
---
N
PES
I
R
I
C
D
F
G
F
A
K
---
Q
-
L
-
R
-
A
-
E
N
-
G
L
L
--
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
-
N
G
P
-----
D
D
-
T
PEE----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
---
A
L
V
L
R
H
P
W
----------
I
-----------
V
------------
H
W
-------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
54.82
38%
-63
- C1 -
-
4MAO
1
A:
[33-297]
-----------------
F
T
D
---
G
Y
E
---
V
K
E
-----
D
I
G
V
G
S
Y
S
---
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
------------------
K
S
K
--
R
--
D
P
--
T
-
E
-
E
I
E
I
L
L
-
R
Y
G
-
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
M
E
L
M
K
G
G
E
L
L
D
-
K
I
L
R
Q
-
K
----
F
--
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y--
V
----
D
---
E
----
S
---
G
---
N
PES
I
R
I
C
D
F
G
F
A
K
---
Q
-
L
-
R
-
A
-
E
N
-
G
L
L
--
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
-
N
G
P
-----
D
D
-
T
PEE----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
---
A
L
V
L
R
H
P
W
----------
I
-----------
V
------------
H
W
-------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
54.72
38%
-51
- C1 -
-
3BQR
4
DAPK3_HUMAN
A:
[5-278]
-------------------
D
---
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
---
K
---
R
---
R
L
S
S
S
R
R
G
V
S
--
R
--
E
E
--
I
E
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
KNVP
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
-
A
-
G
N
------
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
T
I
---
A
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
I
-----------
R
------------
R
-----------
R
---------------
N
V
R
------------------------------------------------------------------------------------------
128
Blastp_CBE
54.70
38%
-64
- C1 -
-
5O1S
2
A:
[42-306]
-----------------
F
T
D
---
G
Y
E
---
V
K
E
-----
D
I
-----
S
---
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
------------------
K
S
K
--
R
--
D
P
--
T
-
E
-
E
I
E
I
L
L
-
R
Y
G
-
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
-
K
I
L
R
Q
-
K
----
F
--
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y--
V
----
D
---
E
----
S
---
G
---
N
PES
I
R
I
C
D
F
G
F
A
K
---
Q
-
L
-
R
-
A
-
E
N
-
G
L
L
--
M
T
P
C
---
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
-
N
G
P
-----
D
D
-
T
PEE----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
---
A
L
V
L
R
H
P
W
----------
I
-----------
V
------------
H
W
-------------------------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
54.64
35%
-39
- C1 -
-
2X4F
3
MYLK4_HUMAN
B:
[95-349]
-------------------------------
E
-----
I
L
G
G
G
--
G
---
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
---
T
---
R
G
M
K
D
--
K
E
E
V
K
-------------
N
-
E
I
S
V
M
N
-
Q
L
D
--
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
S
-
Y
----
N
--
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
-
L
---
C
VN--
R
---
D
----
A
---
K
---
Q
---
I
K
I
I
D
F
G
L
A
R
---
R
-
Y
-
K
-
P
-
R
E
-
K
L
K
--
V
N
-
F
G
T
P
E
F
L
A
P
E
V
V
-----
N
Y
D
F
V
S
F
---
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
------
L
-
G
D
N
-----
D
A
-
E
-------
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
---
S
E
A
L
K
H
P
W
----------
L
-----------
S
------------
D
H
-------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
54.24
38%
-59
- C1 -
-
4JG7
1
A:
[33-297]
-----------------
F
T
D
---
G
Y
E
---
V
K
E
-----
D
I
G
V
--
Y
S
---
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
------------------
K
S
K
--
R
--
D
P
--
T
-
E
-
E
I
E
I
L
L
-
R
Y
G
-
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
-
K
I
L
R
Q
-
K
----
F
--
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y--
V
----
D
---
E
----
S
---
G
---
N
PES
I
R
I
C
D
F
G
F
A
K
---
Q
-
L
-
R
-
A
-
E
N
-
G
L
L
--
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
-
N
G
P
-----
D
D
-
T
PEE----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
---
A
L
V
L
R
H
P
W
----------
I
-----------
V
------------
H
W
-------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
54.13
38%
-55
- C1 -
-
4M8T
1
A:
[33-297]
-----------------
F
T
D
---
G
Y
E
---
V
K
E
-----
D
I
G
V
G
S
Y
S
---
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
------------------
K
S
K
--
R
--
D
P
--
T
-
E
-
E
I
E
I
L
L
-
R
Y
G
-
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
M
E
L
M
K
G
G
E
L
L
D
-
K
I
L
R
Q
-
K
----
F
--
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y--
V
----
D
---
E
----
S
---
G
---
N
PES
I
R
I
C
D
F
G
F
A
K
---
Q
-
L
-
R
-
A
-
E
N
-
G
L
L
--
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
-
N
G
P
-----
D
D
-
T
PEE----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
---
A
L
V
L
R
H
P
W
----------
I
-----------
V
------------
H
W
-------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
54.01
36%
-68
- C1 -
-
3HZT
9
?
A:
[4-298]
-------------------
D
---
R
Y
Q
---
R
V
K
-----
K
L
G
S
G
A
Y
G
---
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
I
I
K
---
K
---
S
S
V
T
T
T
S
N
S
G
----------
A
--
L
L
D
-
E
V
A
V
L
K
-
Q
L
D
--
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
-
E
I
I
L
R
-
Q
----
K
--
F
S
E
V
D
A
A
V
I
M
K
Q
V
L
S
G
T
T
Y
L
H
K
H
N
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
E
---
S
----
K
---
S
---
R
DAL
I
K
I
V
D
F
G
L
S
A
---
H
-
F
-
E
-
V
-------------
G
T
A
Y
Y
I
A
P
E
V
L
--------
R
K
K
Y
-
D
E
K
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
------
G
-
G
Q
T
-----
D
Q
-
E
-------
I
L
K
R
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
S
K
R
I
S
A
---
E
E
A
L
N
H
P
W
----------
I
-----------
V
------------
K
F
-------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
53.93
38%
-56
- C1 -
-
4JG6
1
A:
[33-297]
-----------------
F
T
D
---
G
Y
E
---
V
K
E
-----
D
I
-----
S
---
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
I
I
D
------------------
K
S
K
--
R
--
D
P
--
T
-
E
-
E
I
E
I
L
L
-
R
Y
G
-
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
-
K
I
L
R
Q
-
K
----
F
--
F
S
E
R
E
A
S
A
V
L
F
T
I
T
K
T
V
E
Y
L
H
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y--
V
----
D
---
E
----
S
---
G
---
N
PES
I
R
I
C
D
F
G
F
A
K
---
Q
-
L
-
R
-
A
-
E
N
-
G
L
L
--
M
T
P
C
Y
T
A
N
F
V
A
P
E
V
L
E
-------
R
Q
G
Y
-
D
A
A
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
------
A
-
N
G
P
-----
D
D
-
T
PEE----
I
L
A
R
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
H
Q
R
L
T
A
---
A
L
V
L
R
H
P
W
----------
I
-----------
V
------------
H
W
-------------------------------------------------------------------------------------------------------------------------------------------------
581
HHSearch
53.55
34%
-40
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[89-350]
-------------------
Y
---
T
V
S
---
K
T
E
-----
I
L
-----
G
---
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
I
I
K
---
T
---
R
G
M
-
K
--------
D
--
K
--
E
E
--
V
K
N
-
E
I
S
V
M
N
-
Q
L
--
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
-
R
I
I
D
E
S
Y
----
N
--
L
T
E
L
D
T
I
L
F
M
K
Q
I
C
E
G
I
R
H
M
H
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
-
L
---
C
VN--
R
---
D
----
A
---
K
---
Q
---
I
K
I
I
D
F
G
L
A
R
---
R
-
Y
-
K
-
P
-
R
E
-
K
L
K
--
V
N
-
F
G
T
P
E
F
L
A
P
E
V
V
N
-
Y
------
D
F
V
-
S
F
P
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
------
L
-
G
D
N
-----
D
A
-
E
-------
T
L
N
N
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
S
W
R
I
S
A
---
S
E
A
L
K
H
P
W
----------
L
-----------
S
------------
D
H
-----------
K
-------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
53.37
38%
-40
- C1 -
-
6AAR
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
---------------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-
F
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
52.87
36%
-93
- C1 -
-
4RER
2
AAPK1_HUMAN
A:
[12-345]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
52.70
36%
-91
- C1 -
-
5UFU
2
AAPK1_MOUSE (first)
A:
[22-398]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
52.55
33%
-26
- C1 -
-
4YSJ
1
?
B:
[23-330]
----------
H
S
T
--
A
A
F
S
D
---
R
Y
K
---
G
Q
R
-----
V
L
G
K
G
S
F
G
---
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
--------------
S
K
R
----------------
L
-
L
K
E
V
E
L
-
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
-
K
----
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
E
---
N
KRK-
D
---
A
---
N
---
I
R
I
I
D
F
G
L
S
T
---
H
-
F
-
E
-
S
-
T
K
-
K
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
-
G
A
N
-----
E
F
-
D
-------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
---
R
D
A
L
E
H
E
W
----------
L
-----------
K
TTDADSIDVPSL
E
S
-----------
T
------------
I
-----------
L
---------------
N
I
R
Q
F
Q
G
T
Q
K
L
A
A
A
A
L
L
Y
M
G
S
------------------------------------------------------------------------
386
Blastp_CBE
52.52
36%
-89
- C1 -
-
6E4U
2
AAPK1_RAT
A:
[22-401]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
52.52
36%
-91
- C1 -
-
6E4W
2
?
A:
[22-405]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
52.46
36%
-94
- C1 -
-
4QFS
2
A:
[22-405]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
52.46
36%
-85
- C1 -
-
5T5T
2
AAPK1_RAT
A:
[22-398]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
52.34
32%
-68
- C1 -
-
4CZU
3
CIPKN_ARATH
C:
[9-275]
-----------------
R
V
G
---
K
Y
E
---
L
G
R
-----
T
L
G
E
G
T
F
A
---
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
-------------
K
E
K
V
L
K
N
K
--
M
--
I
A
--
Q
I
K
-
R
E
I
S
T
M
-
K
L
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
-
K
I
S
S
N
-
G
----
R
--
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
---
L
----
D
---
A
----
N
---
G
---
A
---
L
K
V
S
D
F
G
L
S
A
LPQ
Q
-
V
-
R
-
E
-
D
G
-
L
L
H
--
D
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
-------
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
-
D
S
N
-----
L
T
-
S
-------
L
Y
K
K
I
F
K
A
--
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
---
A
E
V
I
E
N
E
W
----------
F
-----------
K
------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
52.13
36%
-92
- C1 -
-
4QFG
1
A:
[22-401]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
51.97
32%
-59
- C1 -
-
4CZT
3
CIPKN_ARATH
A:
[2-272]
--------
G
I
H
S
G
--
R
T
R
V
G
---
K
Y
E
---
L
G
R
-----
T
L
G
E
G
T
F
A
---
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
-------------
K
E
K
V
L
K
N
K
--
M
--
I
A
--
Q
I
K
-
R
E
I
S
T
M
-
K
L
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
-
K
I
S
S
N
-
G
----
R
--
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
-
L
---
L
----
D
---
A
----
N
---
G
---
A
---
L
K
V
S
D
F
G
L
S
A
LPQ
Q
-
V
-
R
-
E
-
D
G
-
L
L
H
--
T
T
-
C
G
T
P
N
Y
V
A
P
E
V
I
-------
N
N
K
G
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
------
E
-
D
S
N
-----
L
T
-
S
-------
L
Y
K
K
I
F
K
A
--
E
F
T
C
P
P
W
--
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
---
A
E
V
I
E
N
E
W
----------
F
-----------
K
------------
K
--------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
51.90
36%
-90
- C1 -
-
4QFR
2
?
A:
[22-405]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
51.89
37%
12
- C1 -
-
4IEB
1
?
A:
[42-317]
----------
H
S
T
--
A
I
F
S
D
---
R
Y
K
---
G
Q
R
-----
V
L
G
K
G
S
F
G
---
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------------
S
K
R
Q
V
---TD
K
--
E
S
--
L
L
R
-
E
V
Q
L
L
K
-
Q
L
D
--
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
-
K
----
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
E
---
S
KSK-
D
---
A
---
N
---
I
R
I
I
D
F
G
L
S
T
---
H
-
F
-
E
-
A
-
S
K
-
K
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
-
G
A
N
-----
E
Y
-
D
-------
I
L
K
K
V
E
K
G
K
Y
T
F
E
-
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
---
R
D
A
L
D
H
E
W
----------
I
-----------
Q
------------
T
Y
-----------
T
------------
K
-----------
E
---------------
Q
I
-------------------------------------------------------------------------------------------
191
Blastp_CBE
51.60
33%
-24
- C1 -
-
4YSJ
1
?
A:
[23-330]
----------
H
S
T
--
A
A
F
S
D
---
R
Y
K
---
G
Q
R
-----
V
L
G
K
G
S
F
G
---
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
V
I
--------------
S
K
R
----------------
L
-
L
K
E
V
E
L
-
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
-
K
----
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
E
---
N
KRK-
D
---
A
---
N
---
I
R
I
I
D
F
G
L
S
T
---
H
-
F
-
E
-
S
-
T
K
-
K
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
-
G
A
N
-----
E
F
-
D
-------
I
L
K
K
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
T
M
R
I
S
A
---
R
D
A
L
E
H
E
W
----------
L
-----------
K
TTSIDVPSL---
E
S
-----------
T
------------
I
-----------
L
---------------
N
I
R
Q
F
Q
G
T
Q
K
L
A
A
A
A
L
L
Y
M
G
S
------------------------------------------------------------------------
390
Blastp_CBE
51.58
36%
-88
- C1 -
-
5KQ5
2
?
A:
[22-403]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
51.35
36%
-89
- C1 -
-
6E4T
2
?
A:
[22-405]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
51.30
37%
-75
- C1 -
-
2YIQ
1
CHK2_HUMAN
A:
[10-279]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
----
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
--------------------------
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-
G
-
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
50.85
36%
-94
- C1 -
-
4CFH
1
AAPK1_RAT
A:
[39-350]
-------------------------------
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
I
L
N
---
R
---
Q
K
I
R
S
L
--
D
V
V
G
K
I
--
R
--------
R
-
E
I
Q
N
L
--
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
-
G
----
R
--
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
D
H
-----
V
P
-
T
-------
L
F
K
K
I
C
D
G
--
I
F
Y
T
P
Q
Y
--
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
50.62
33%
-36
- C1 -
-
3LM0
2
ST17B_HUMAN
A:
[37-301]
--------------------------------------
L
G
R
G
K
F
A
---
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
---
K
---
R
R
R
G
-------
Q
D
C
--
R
--
A
E
--
I
L
H
-
E
I
A
V
L
E
-
L
A
K
-
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
-
L
C
L
P
E
-
L
----
A
EM
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
---
L
----
S
---
S
----
I
---
Y
PLG
D
---
I
K
I
V
D
F
G
M
S
R
---
K
----------------
I
-
M
G
T
P
E
Y
L
A
P
E
I
L
-------
N
Y
D
P
I
-
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
------
V
-
G
E
D
-----
N
Q
-
E
-------
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
---
E
I
C
L
S
H
S
W
----------
L
-----------
Q
------------
Q
W
-----------
D
------------
F
-----------
E
---------------
N
L
F
H
-----------------------------------------------------------------------------------------
136
Blastp_CBE
50.46
38%
-56
- C1 -
-
3ZXT
1
DAPK1_HUMAN
C:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
--
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
S
-
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
-----------------
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
50.35
33%
-34
- C1 -
-
6QF4
2
ST17B_HUMAN
A:
[37-301]
--------------------------------------
L
G
R
G
K
F
A
---
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
---
K
---
R
R
R
G
-------
Q
D
C
--
R
--
A
E
--
I
L
H
-
E
I
A
V
L
E
-
L
A
K
-
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
-
L
C
L
P
E
-
L
----
A
EM
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
---
L
----
S
---
S
----
I
---
Y
PLG
D
---
I
K
I
V
D
F
G
M
S
R
---
K
-
I
-
G
-
H
-
A
C
-------
I
-
M
G
T
P
E
Y
L
A
P
E
I
L
-------
N
Y
D
P
I
-
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
------
V
-
G
E
D
-----
N
Q
-
E
-------
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
---
E
I
C
L
S
H
S
W
----------
L
-----------
Q
------------
Q
W
-----------
D
------------
F
-----------
E
---------------
N
L
F
H
-----------------------------------------------------------------------------------------
138
Blastp_CBE
50.14
38%
-63
- C1 -
-
3ZXT
1
DAPK1_HUMAN
A:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
-------------
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
--------
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
------------------
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
49.44
38%
-52
- C1 -
-
3ZXT
1
DAPK1_HUMAN
B:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
K
---
K
---
R
R
T
K
--
S
R
R
G
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
K
---------
L
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
----------------
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
---
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
49.37
33%
-32
- C1 -
-
3LM5
1
ST17B_HUMAN
A:
[37-299]
--------------------------------------
L
G
R
G
K
F
A
---
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
F
L
K
---
K
---
R
R
R
G
-------
Q
D
C
--
R
--
A
E
--
I
L
H
-
E
I
A
V
L
E
-
L
A
K
-
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
-
L
C
L
P
E
-
L
-----EM
V
S
E
N
D
V
I
R
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
---
L
----
S
---
S
----
I
---
Y
PLG
D
---
I
K
I
V
D
F
G
M
S
R
---
K
----------------
I
-
M
G
T
P
E
Y
L
A
P
E
I
L
-------
N
Y
D
P
I
-
T
T
A
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
------
V
-
G
E
D
-----
N
Q
-
E
-------
T
Y
L
N
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
E
K
R
P
T
A
---
E
I
C
L
S
H
S
W
----------
L
-----------
Q
------------
Q
W
-----------
D
------------
F
-----------
E
---------------
N
L
-------------------------------------------------------------------------------------------
20
PsiBlast_PDB
49.19
35%
-9
- C1 -
-
4FG9
1
KCC1A_HUMAN
A:
[10-314]
---------
W
K
Q
A
--
E
D
I
R
D
---
I
Y
D
---
F
R
D
-----
V
L
G
T
G
A
F
S
---
E
V
I
L
A
E
D
K
R
T
Q
K
L
V
A
I
K
C
I
---------------
A
K
E
---------------
E
N
E
I
A
V
L
H
-
K
I
K
--
H
P
N
I
V
A
L
D
D
I
Y
E
S
G
G
H
L
Y
L
I
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
-
G
----
F
--
Y
T
E
R
D
A
S
R
L
I
F
Q
V
L
D
A
V
K
Y
L
H
D
L
G
I
V
H
R
D
L
K
P
E
N
L
-
L
YYS
L
----
D
---
E
----
D
---
S
---
K
---
I
M
I
S
D
F
-----------------------------
P
G
Y
V
A
P
E
V
L
A
-------
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
-
D
E
N
-----
D
A
-
K
-------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
H
L
M
E
K
D
P
E
K
R
F
T
C
---
E
Q
A
L
Q
H
P
W
IAGDTALDKN
I
-----------
H
------------
Q
S
-----------
V
------------
S
-----------
E
---------------
Q
I
K
K
N
F
A
K
S
K
W
K
Q
-
A
F
N
A
T
A
V
V
R
----------------------------------------------------------------------
69
Blastp_CBE
48.99
37%
19
- C1 -
-
3T3U
5
?
A:
[22-304]
---------------
A
I
F
S
D
---
R
Y
K
---
G
Q
R
-----
V
L
G
K
G
S
F
G
---
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------------
S
K
R
Q
V
K
Q
K
TD
K
--
E
S
--
L
L
R
-
E
V
Q
L
L
K
-
Q
L
D
--
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
-
K
----
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
E
---
S
KSK-
D
---
A
---
N
---
I
R
I
I
D
F
G
L
S
T
---
H
-
F
-
E
-
A
-
S
K
-
K
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
-
G
A
N
-----
E
Y
-
D
-------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
---
R
D
A
L
D
H
E
W
----------
I
-----------
Q
------------
T
Y
-----------
T
------------
K
-----------
E
---------------
Q
I
-------------------------------------------------------------------------------------------
58
Blastp_CBE
48.98
37%
17
- C1 -
-
4WG3
1
?
A:
[20-387]
-----------
S
T
--
A
I
F
S
D
---
R
Y
K
---
G
Q
R
-----
V
L
G
K
G
S
F
G
---
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------------
S
K
R
Q
V
K
Q
K
TD
K
--
E
S
--
L
L
R
-
E
V
Q
L
L
K
-
Q
L
D
--
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
-
K
----
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
E
---
S
KSK-
D
---
A
---
N
---
I
R
I
I
D
F
G
L
S
T
---
H
-
F
-
E
-
A
-
S
K
-
K
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
-
G
A
N
-----
E
Y
-
D
-------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
---
R
D
A
L
D
H
E
W
----------
I
-----------
Q
------------
T
Y
-----------
T
------------
K
-----------
E
---------------
Q
I
-------------------------------------------------------------------------------------------
442
Blastp_CBE
48.92
33%
-70
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[7-264]
-------------------
E
---
D
F
K
---
V
G
N
-----
L
L
G
K
G
S
F
A
---
G
V
Y
R
A
E
S
I
H
T
G
L
E
V
A
I
K
M
I
D
---
K
---
K
A
--
M
Y
K
A
G
M
V
Q
R
V
--
Q
--------
N
-
E
V
K
I
H
C
-
Q
L
K
--
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
-
Y
L
K
N
R
-
V
----
K
P-
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
H
G
I
L
H
R
D
L
T
L
S
N
L
-
L
---
L
----
T
---
R
----
N
---
M
---
N
---
I
K
I
A
D
F
G
L
A
T
---
Q
-
L
-
K
M
P
-
H
-------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----------------
V
K
-
N
-------
T
L
N
K
V
V
L
A
D
Y
E
M
--
P
S
F
--
L
S
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
L
S
L
---
S
S
V
L
D
H
P
F
----------
M
-----------
S
------------
R
--------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
48.92
37%
18
- C1 -
-
3I7B
4
?
A:
[23-296]
----------------
I
F
S
D
---
R
Y
K
---
G
Q
R
-----
V
L
G
K
G
S
F
G
---
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------------
S
K
R
Q
V
K
Q
K
TD
K
--
E
S
--
L
L
R
-
E
V
Q
L
L
K
-
Q
L
D
--
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
-
K
----
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
E
---
S
KSK-
D
---
A
---
N
---
I
R
I
I
D
F
G
L
S
T
---
H
-
F
-
E
-
A
-
S
K
-
K
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
-
G
A
N
-----
E
Y
-
D
-------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
---
R
D
A
L
D
H
E
W
----------
I
-----------
Q
------------
T
Y
-----------
T
------------
K
-----------
E
---------------
Q
I
-------------------------------------------------------------------------------------------
262
Blastp_CBE
48.78
37%
-29
- C1 -
-
2CN5
1
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
G
A
C
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
---
R
--------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-
G
-
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
48.74
37%
19
- C1 -
-
3N51
3
?
A:
[22-308]
---------------
A
I
F
S
D
---
R
Y
K
---
G
Q
R
-----
V
L
G
K
G
S
F
G
---
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
--------------
S
K
R
Q
V
K
Q
K
TD
K
--
E
S
--
L
L
R
-
E
V
Q
L
L
K
-
Q
L
D
--
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
-
K
----
R
--
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
---
L
----
E
---
S
KSK-
D
---
A
---
N
---
I
R
I
I
D
F
G
L
S
T
---
H
-
F
-
E
-
A
-
S
K
-
K
M
K
--
D
K
-
I
G
T
A
Y
Y
I
A
P
E
V
L
--------
H
G
T
Y
-
D
E
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
------
N
-
G
A
N
-----
E
Y
-
D
-------
I
L
K
K
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
I
S
A
---
R
D
A
L
D
H
E
W
----------
I
-----------
Q
------------
T
Y
-----------
T
------------
K
-----------
E
---------------
Q
I
-------------------------------------------------------------------------------------------
45
Blastp_CBE
48.08
38%
-23
- C1 -
-
6T6F
1
?
A:
[9-287]
------------
A
--
E
D
I
K
K
---
I
F
E
---
F
K
E
-----
T
L
G
T
G
A
F
S
---
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
---------------
P
K
K
A
L
K
G
--
K
--
E
S
--
S
I
E
N
E
I
A
V
L
R
-
K
I
K
--
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
-
G
----
F
--
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
YSQ-
D
---
E
----
E
---
S
---
K
---
I
M
I
S
D
F
G
L
S
--------------------------
P
G
Y
V
A
P
E
V
L
A
-------
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
-
D
E
N
-----
D
S
-
K
-------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
---
E
Q
A
A
R
H
P
W
----------
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
48.06
37%
-25
- C1 -
-
4BDG
2
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
---
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
------------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-
G
-
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
47.89
38%
-67
- C1 -
-
3ZXT
1
DAPK1_HUMAN
D:
[13-276]
------------------------
Y
D
---
T
G
E
-----
E
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
F
I
------------------
V
S
----
R
--
E
D
--
I
E
R
-
E
V
S
I
L
K
-
E
I
Q
--
H
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-
F
L
A
E
-----------
T
E
E
E
A
T
E
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
----
D
---
R
----
N
---
V
PKP
R
---
I
K
I
I
D
F
G
L
A
H
---
K
-
I
-
D
----------------
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
D
T
-----
K
Q
-
E
-------
T
L
A
N
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
K
R
M
T
I
---
Q
D
S
L
Q
H
P
W
----------
I
-----------
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
47.69
37%
-36
- C1 -
-
2YCS
1
CHK2_HUMAN
A:
[10-279]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
---
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
------------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-----
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
47.39
37%
-27
- C1 -
-
2YCR
1
CHK2_HUMAN
A:
[10-279]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
---
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
------------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-
G
-
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
47.30
37%
-34
- C1 -
-
4BDD
3
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
------------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-----
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
567
Blastp_CBE
47.10
33%
-14
- C1 -
-
2F7X
1
KAPCA_BOVIN
E:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
----
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
46.91
37%
-21
- C1 -
-
4BDC
2
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
------------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
---
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
46.90
37%
-29
- C1 -
-
4BDH
4
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
------------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-
G
-
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
46.78
37%
-24
- C1 -
-
4BDJ
1
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
--------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
------------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
---
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
565
Blastp_CBE
46.71
33%
-12
- C1 -
-
2OH0
1
KAPCA_BOVIN
E:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
----
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
46.68
37%
-23
- C1 -
-
4BDF
3
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
----
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
------------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-
G
-
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
46.65
38%
-24
- C1 -
-
6T6F
1
?
B:
[9-287]
------------
A
--
E
D
I
K
K
---
I
F
E
---
F
K
E
-----
T
L
G
T
G
A
F
S
---
E
V
V
L
A
E
E
K
A
T
G
K
L
F
A
V
K
C
I
---------------
P
K
K
A
L
K
G
--
K
--
E
S
--
S
I
E
N
E
I
A
V
L
R
-
K
I
K
--
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
-
G
----
F
--
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
M
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
YSQ-
D
---
E
----
E
---
S
---
K
---
I
M
I
S
D
F
G
----------------------------
P
G
Y
V
A
P
E
V
L
A
-------
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
------
Y
-
D
E
N
-----
D
S
-
K
-------
L
F
E
Q
I
L
K
A
E
Y
E
F
D
S
P
Y
W
D
D
I
S
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
Y
T
C
---
E
Q
A
A
R
H
P
W
----------
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
46.53
37%
-29
- C1 -
-
4BDA
8
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
------------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
---
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
46.37
33%
18
- C1 -
-
6CJY
1
MKNK2_HUMAN
A:
[4-300]
--------
D
S
F
S
G
RF
E
D
V
Y
Q
---
L
Q
E
-----
D
-----
V
L
G
E
G
A
H
A
---
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
---
K
---
Q
P
G
---------
H
I
--
R
--
S
R
--
V
F
R
-
E
V
E
M
L
Y
-
Q
C
Q
-
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
-
H
I
H
K
R
-
R
----
H
--
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
-
L
---
C
----
E
---
H
----
P
---
N
---
Q
VSP
V
K
I
C
D
F
G
--------------------------
G
S
A
E
Y
M
A
P
E
V
V
E
--
A
F
S
E
E
A
S
I
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
-------
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
---
A
Q
V
L
Q
H
P
W
----------
V
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
46.25
34%
-33
- C1 -
-
6B2E
2
AAPK2_HUMAN
A:
[22-385]
------------
G
--
R
V
K
I
G
---
H
Y
V
---
L
G
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
---
R
-----------
Q
K
I
R
S
L
--
D
--
V
V
--
G
K
I
-
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
H
-
G
----
R
--
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
N
---
M
-
M
-
S
-
D
-
G
E
-
F
L
R
--
S
--
C
G
S
P
N
Y
A
A
P
E
V
I
S
-
G
R
L
Y
A
------
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
E
H
-----
V
P
-
T
-------
L
F
K
K
I
R
G
G
V
F
Y
I
--
P
E
Y
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
G
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
564
Blastp_CBE
46.17
33%
-11
- C1 -
-
2OJF
1
KAPCA_BOVIN
E:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
----
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
46.15
33%
25
- C1 -
-
6CJ5
1
MKNK2_HUMAN
A:
[4-300]
--------
D
S
F
S
G
RF
E
D
V
Y
Q
---
L
Q
E
-----
D
-----
V
L
G
E
G
A
H
A
---
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
---
K
---
Q
P
G
---------
H
I
--
R
--
S
R
--
V
F
R
-
E
V
E
M
L
Y
-
Q
C
Q
-
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
-
H
I
H
K
R
-
R
----
H
--
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
-
L
---
C
----
E
---
H
----
P
---
N
---
Q
VSP
V
K
I
C
D
F
G
--------------------------
G
S
A
E
Y
M
A
P
E
V
V
E
--
A
F
S
E
E
A
S
I
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
-------
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
---
A
Q
V
L
Q
H
P
W
----------
V
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
555
Blastp_CBE
46.02
33%
-9
- C1 -
-
2UZU
1
KAPCA_BOVIN
E:
[27-267]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
----
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
45.91
35%
-51
- C1 -
-
6BX6
1
AAPK2_HUMAN
A:
[12-269]
-----------------------
H
Y
V
---
L
G
D
-----
T
L
G
V
G
T
F
G
---
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
--------------
R
Q
K
I
R
S
L
--
D
--
V
V
--
G
K
I
-
K
R
E
I
Q
N
L
K
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
H
-
G
----
R
--
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
---
L
----
D
---
A
----
H
---
M
---
N
---
A
K
I
A
D
F
G
L
S
---------------------------
N
Y
A
A
P
E
-------
Y
A
------
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
------
D
-
D
E
H
-----
V
P
-
T
-------
L
F
K
K
I
R
G
G
V
F
Y
I
--
P
E
Y
L
N
R
S
--
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
---
K
D
I
R
E
H
E
W
----------
F
-----------
K
------------
Q
D
-----------
L
-------------------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
45.88
33%
16
- C1 -
-
6CJW
1
MKNK2_HUMAN
A:
[4-300]
--------
D
S
F
S
G
RF
E
D
V
Y
Q
---
L
Q
E
-----
D
-----
V
L
G
E
G
A
H
A
---
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
---
K
---
Q
P
G
---------
H
I
--
R
--
S
R
--
V
F
R
-
E
V
E
M
L
Y
-
Q
C
Q
-
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
-
H
I
H
K
R
-
R
----
H
--
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
-
L
---
C
----
E
---
H
----
P
---
N
---
Q
VSP
V
K
I
C
D
F
G
--------------------------
G
S
A
E
Y
M
A
P
E
V
V
E
--
A
F
S
E
E
A
S
I
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
-------
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
---
A
Q
V
L
Q
H
P
W
----------
V
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
45.66
33%
23
- C1 -
-
6CK3
1
MKNK2_HUMAN
A:
[4-300]
--------
D
S
F
S
G
RF
E
D
V
Y
Q
---
L
Q
E
-----
D
-----
V
L
G
E
G
A
H
A
---
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
---
K
---
Q
P
G
---------
H
I
--
R
--
S
R
--
V
F
R
-
E
V
E
M
L
Y
-
Q
C
Q
-
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
-
H
I
H
K
R
-
R
----
H
--
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
-
L
---
C
----
E
---
H
----
P
---
N
---
Q
VSP
V
K
I
C
D
F
G
--------------------------
G
S
A
E
Y
M
A
P
E
V
V
E
--
A
F
S
E
E
A
S
I
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
-------
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
---
A
Q
V
L
Q
H
P
W
----------
V
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
45.44
37%
-42
- C1 -
-
2CN8
1
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
------------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-----
T
S
-
L
M
R
--
T
L
-
C
--
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
--------
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
45.42
33%
22
- C1 -
-
6CK6
1
MKNK2_HUMAN
A:
[4-300]
--------
D
S
F
S
G
RF
E
D
V
Y
Q
---
L
Q
E
-----
D
-----
V
L
G
E
G
A
H
A
---
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
---
K
---
Q
P
G
---------
H
I
--
R
--
S
R
--
V
F
R
-
E
V
E
M
L
Y
-
Q
C
Q
-
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
-
H
I
H
K
R
-
R
----
H
--
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
-
L
---
C
----
E
---
H
----
P
---
N
---
Q
VSP
V
K
I
C
D
F
G
--------------------------
G
S
A
E
Y
M
A
P
E
V
V
E
--
A
F
S
E
E
A
S
I
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
-------
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
---
A
Q
V
L
Q
H
P
W
----------
V
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
45.30
33%
24
- C1 -
-
6CJH
1
MKNK2_HUMAN
A:
[4-300]
--------
D
S
F
S
G
RF
E
D
V
Y
Q
---
L
Q
E
-----
D
-----
V
L
G
E
G
A
H
A
---
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
---
K
---
Q
P
G
---------
H
I
--
R
--
S
R
--
V
F
R
-
E
V
E
M
L
Y
-
Q
C
Q
-
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
-
H
I
H
K
R
-
R
----
H
--
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
-
L
---
C
----
E
---
H
----
P
---
N
---
Q
VSP
V
K
I
C
D
F
G
--------------------------
G
S
A
E
Y
M
A
P
E
V
V
E
--
A
F
S
E
E
A
S
I
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
-------
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
---
A
Q
V
L
Q
H
P
W
----------
V
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
45.26
33%
10
- C1 -
-
6CJE
1
MKNK2_HUMAN
A:
[4-300]
--------
D
S
F
S
G
RF
E
D
V
Y
Q
---
L
Q
E
-----
D
-----
V
L
G
E
G
A
H
A
---
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
---
K
---
Q
P
G
---------
H
I
--
R
--
S
R
--
V
F
R
-
E
V
E
M
L
Y
-
Q
C
Q
-
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
-
H
I
H
K
R
-
R
----
H
--
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
-
L
---
C
----
E
---
H
----
P
---
N
---
Q
VSP
V
K
I
C
D
F
G
-----------------------
P
-
C
G
S
A
E
Y
M
A
P
E
V
V
E
--
A
F
S
E
E
A
S
I
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
-------
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
---
A
Q
V
L
Q
H
P
W
----------
V
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
45.21
33%
20
- C1 -
-
2HW7
1
MKNK2_HUMAN
A:
[4-300]
--------
D
S
F
S
G
RF
E
D
V
Y
Q
---
L
Q
E
-----
D
-----
V
L
G
E
G
A
H
A
---
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
---
K
---
Q
P
G
---------
H
I
--
R
--
S
R
--
V
F
R
-
E
V
E
M
L
Y
-
Q
C
Q
-
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
-
H
I
H
K
R
-
R
----
H
--
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
-
L
---
C
----
E
---
H
----
P
---
N
---
Q
VSP
V
K
I
C
D
F
G
--------------------------
G
S
A
E
Y
M
A
P
E
V
V
E
--
A
F
S
E
E
A
S
I
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
-------
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
---
A
Q
V
L
Q
H
P
W
----------
V
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
44.99
37%
11
- C1 -
-
2XM9
1
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
---
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
----------------------
P
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-
G
-
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
44.80
33%
21
- C1 -
-
6CKI
1
MKNK2_HUMAN
A:
[4-300]
--------
D
S
F
S
G
RF
E
D
V
Y
Q
---
L
Q
E
-----
D
-----
V
L
G
E
G
A
H
A
---
R
V
Q
T
C
I
N
L
I
T
S
Q
E
Y
A
V
K
I
I
E
---
K
---
Q
P
G
---------
H
I
--
R
--
S
R
--
V
F
R
-
E
V
E
M
L
Y
-
Q
C
Q
-
G
H
R
N
V
L
E
L
I
E
F
F
E
E
E
D
R
F
Y
L
V
F
E
K
M
R
G
G
S
I
L
S
-
H
I
H
K
R
-
R
----
H
--
F
N
E
L
E
A
S
V
V
V
Q
D
V
A
S
A
L
D
F
L
H
N
K
G
I
A
H
R
D
L
K
P
E
N
I
-
L
---
C
----
E
---
H
----
P
---
N
---
Q
VSP
V
K
I
C
D
F
G
--------------------------
G
S
A
E
Y
M
A
P
E
V
V
E
--
A
F
S
E
E
A
S
I
Y
-
D
K
R
C
D
L
W
S
L
G
V
I
L
Y
I
L
L
S
G
Y
P
P
F
VGRCCG-----ACPAC
Q
N
-
M
-------
L
F
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
A
H
I
S
C
A
A
K
D
L
I
S
K
L
L
V
R
D
A
K
Q
R
L
S
A
---
A
Q
V
L
Q
H
P
W
----------
V
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
566
Blastp_CBE
44.51
33%
-9
- C1 -
-
2F7Z
1
KAPCA_BOVIN
E:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
----
R
T
W
--
T
L
-
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
44.41
37%
15
- C1 -
-
4A9T
4
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
---
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
----------------------
P
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-
G
-
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
44.18
37%
5
- C1 -
-
2WTI
3
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
----------------------
P
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
---
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
44.08
37%
11
- C1 -
-
2XBJ
1
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
G
A
-
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
-----------------------
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-----
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
44.05
37%
8
- C1 -
-
4A9R
2
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
----------------------
P
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-
G
-
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
43.89
37%
12
- C1 -
-
4BDK
4
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
----
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
-----------------------
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-
G
-
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
43.86
37%
-29
- C1 -
-
2XM8
1
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
--------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
------------------------------N-
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-----
T
S
-
L
M
R
--
T
L
-
C
G
---
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
43.68
38%
-16
- C1 -
-
2JAM
3
KCC1G_HUMAN
A:
[15-264]
-------------------------------
E
-----
V
L
G
S
G
A
F
S
---
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
---
K
-----------------------
S
--
S
L
E
N
E
I
A
V
L
K
-
K
I
K
--
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
L
E
R
-
G
----
V
--
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
LTP-
E
---
E
----
N
---
S
---
K
---
I
M
I
T
D
F
G
L
S
----
K
-
M
-
E
-
Q
-
N
G
-
I
M
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
A
-------
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
------
Y
-
E
E
T
-----
E
S
-
K
-------
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
---
E
K
A
L
S
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
43.62
37%
12
- C1 -
-
4BDI
6
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
----
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
-----------------------
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-
G
-
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
43.35
37%
6
- C1 -
-
4A9U
10
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
-------------------
D
--
P
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-----
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
43.32
37%
1
- C1 -
-
2WTJ
5
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
----------------------
P
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
---
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
43.32
38%
-8
- C1 -
-
2JAM
3
KCC1G_HUMAN
B:
[15-264]
-------------------------------
E
-----
V
L
G
S
G
A
F
S
---
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
K
---
K
-----------------------
S
--
S
L
E
N
E
I
A
V
L
K
-
K
I
K
--
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
L
E
R
-
G
----
V
--
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
---
Y
LTP-
E
---
E
----
N
---
S
---
K
---
I
M
I
T
D
F
G
L
S
----
K
-
M
-
E
-
Q
-
N
G
-
I
M
S
--
T
A
-
C
G
T
P
G
Y
V
A
P
E
V
L
A
-------
Q
K
P
Y
-
S
K
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
------
Y
-
E
E
T
-----
E
S
-
K
-------
L
F
E
K
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
Y
T
C
---
E
K
A
L
S
H
P
W
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
43.29
37%
4
- C1 -
-
2WTD
4
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
----------------------
P
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-----
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
43.10
37%
4
- C1 -
-
4A9S
1
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
----------------------
P
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-----
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
42.95
33%
-5
- C1 -
-
5N1E
4
KAPCA_CRIGR
A:
[33-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
42.80
33%
-3
- C1 -
-
5MHI
3
KAPCA_CRIGR
A:
[34-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
42.76
34%
-12
- C1 -
-
5TX3
2
MELK_HUMAN
B:
[2-269]
---------
S
G
S
M
--
K
D
Y
D
E
LLK
Y
Y
E
---
L
H
E
-----
T
I
G
--------
K
V
K
L
A
C
H
I
L
T
G
E
M
V
A
I
K
I
M
D
---
K
-----------------------
K
--
T
---
E
I
E
A
L
K
-
N
L
R
--
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
-
D
----
R
--
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
Q
G
Y
A
H
R
D
L
K
P
E
N
L
-
L
---
F
----
D
---
E
----
Y
---
H
---
K
---
L
K
L
I
D
----------------------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
G
---
L
-
G
S
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
------
D
-
D
D
N
-----
V
M
-
A
-------
L
Y
K
K
I
M
R
G
K
Y
D
V
--
P
K
W
L
S
P
S
S
I
L
--
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
I
S
M
---
K
N
L
L
N
H
P
W
----------
I
-----------
M
------------
Q
--------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
42.54
33%
-4
- C1 -
-
5N32
3
KAPCA_CRIGR
A:
[34-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
----
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
42.51
33%
-2
- C1 -
-
5LCP
3
KAPCA_CRIGR
A:
[36-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
42.49
37%
6
- C1 -
-
4BDB
10
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
------------------------LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
---
E
-
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
42.20
33%
-3
- C1 -
-
5N1D
3
KAPCA_CRIGR
A:
[34-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
42.13
37%
4
- C1 -
-
4BDE
5
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
-----------------------
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-----
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
42.11
33%
-5
- C1 -
-
5M0L
3
KAPCA_CRIGR
A:
[36-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
42.06
33%
-6
- C1 -
-
5LCT
3
KAPCA_CRIGR
A:
[36-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
41.99
34%
-4
- C1 -
-
6C0U
4
KAPCA_HUMAN
A:
[45-285]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
41.97
33%
-0
- C1 -
-
5M6V
1
KAPCA_CRIGR
A:
[36-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
41.91
37%
3
- C1 -
-
2WTC
1
CHK2_HUMAN
A:
[16-285]
-------------------
D
---
E
Y
I
---
M
S
K
-----
T
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
I
I
S
---
K
----------------------
P
A
LN
V
E
T
-
E
I
E
I
L
K
-
K
L
N
--
H
P
C
I
I
K
I
K
N
F
F
D
A
E
D
Y
Y
-
I
V
L
E
L
M
E
G
G
E
L
F
D
-
K
V
V
G
N
-
K
----
R
--
L
K
E
A
T
C
K
L
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
---
L
SSQ-
E
---
E
----
D
---
C
---
L
---
I
K
I
T
D
F
G
H
S
K
---
I
-
L
-----
T
S
-
L
M
R
--
T
L
-
C
G
T
P
T
Y
L
A
P
E
V
L
----
V
S
V
G
T
A
G
Y
-
N
R
A
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
------
S
E
H
R
T
-----
Q
V
-
S
-------
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
K
A
R
F
T
T
---
E
E
A
L
R
H
P
W
----------
L
-----------
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
41.81
33%
-2
- C1 -
-
5M6Y
2
KAPCA_CRIGR
A:
[36-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
41.60
33%
-4
- C1 -
-
3IDC
1
KAPCA_MOUSE
A:
[33-281]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
Q
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
41.56
33%
-4
- C1 -
-
5M71
2
KAPCA_CRIGR
A:
[36-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
41.48
34%
-7
- C1 -
-
3L9L
1
KAPCA_HUMAN
B:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
41.38
34%
-5
- C1 -
-
3L9M
1
KAPCA_HUMAN
A:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
K
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
Blastp_CBE
41.33
33%
-7
- C1 -
-
1BKX
1
KAPCA_MOUSE
A:
[33-281]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
Q
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
41.21
33%
0
- C1 -
-
5N1K
3
KAPCA_CRIGR
A:
[34-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
-
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
41.17
34%
-2
- C1 -
-
3P0M
1
KAPCA_HUMAN
A:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
41.14
33%
-0
- C1 -
-
6MM5
1
KAPCA_MOUSE
E:
[22-270]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
Q
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
41.09
33%
-1
- C1 -
-
6MM8
5
KAPCA_MOUSE
C:
[22-281]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
Q
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
41.07
34%
-2
- C1 -
-
3OVV
2
KAPCA_HUMAN
A:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
41.04
34%
-4
- C1 -
-
3POO
2
KAPCA_HUMAN
A:
[42-286]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
41.01
34%
-3
- C1 -
-
3AGL
1
KAPCA_HUMAN
A:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
40.99
34%
0
- C1 -
-
3VQH
2
KAPCA_HUMAN
A:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
40.95
34%
-6
- C1 -
-
3L9N
1
KAPCA_HUMAN
A:
[42-285]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
K
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
40.93
34%
-3
- C1 -
-
5UZK
1
KAPCA_HUMAN
A:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
40.82
34%
-1
- C1 -
-
3NX8
3
KAPCA_HUMAN
A:
[42-280]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
40.81
34%
-0
- C1 -
-
4UJB
3
KAPCA_HUMAN
A:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
40.79
33%
-1
- C1 -
-
5M0U
8
KAPCA_CRIGR
A:
[36-284]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
H
F
D
---
R
I
K
-----
T
L
G
----
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
40.75
33%
-4
- C1 -
-
6MM7
9
KAPCA_MOUSE
D:
[22-282]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
Q
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
569
Blastp_CBE
40.56
32%
25
- C1 -
-
6G77
2
KS6A6_HUMAN
B:
[13-288]
------
I
P
I
T
H
H
V
--
K
E
G
Y
E
---
K
A
D
---
P
A
Q
FELLK
V
L
G
Q
G
S
F
G
KVF
L
V
R
K
K
T
G
P
D
A
G
Q
L
Y
A
M
K
V
L
K
---
K
---------
A
S
L
K
V
R
D
----------------
D
I
L
V
-
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
-
R
L
S
K
E
-
V
----
L
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
E
----
I
---
G
---
H
---
I
K
L
T
D
F
G
L
S
K
---
E
S
V
-
D
-
Q
-
E
K
-
K
A
Y
--
S
F
-
C
G
T
V
E
Y
M
A
P
E
V
V
-------
N
R
R
G
H
-
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
------
Q
-
G
K
D
-----
R
N
-
E
-------
T
M
N
M
I
L
K
A
--
K
L
G
M
P
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
EGV
E
E
I
K
R
H
L
F
----------
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
559
Blastp_CBE
40.55
34%
-2
- C1 -
-
3MVJ
1
KAPCA_HUMAN
A:
[62-302]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
40.48
34%
-4
- C1 -
-
3L9M
1
KAPCA_HUMAN
B:
[42-282]
-------------------
D
---
Q
F
E
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
K
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
40.46
33%
-3
- C1 -
-
4DIN
1
KAPCA_MOUSE
A:
[33-281]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
Q
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
39.48
33%
2
- C1 -
-
6MM6
1
KAPCA_MOUSE
E:
[22-283]
-------
P
S
Q
N
T
A
--
Q
--
L
D
---
Q
F
D
---
R
I
K
-----
T
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
I
L
D
--------------
K
Q
K
V
V
K
L
--
K
QI
E
H
--
T
L
N
-
E
K
R
I
L
Q
-
A
V
N
--
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
-
H
L
R
R
I
-
G
----
R
--
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
---
I
----
D
---
Q
----
Q
---
G
---
Y
---
I
Q
V
T
D
F
G
F
A
K
---
R
-
V
-
K
-
G
-
R
T
-
W
L
------
C
G
T
P
E
Y
L
A
P
E
I
I
L
-
S
K
------
G
Y
-
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
------
F
-
A
D
Q
-----
P
I
-
Q
-------
I
Y
E
K
I
V
S
G
K
V
R
F
P
S
----
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
496
Blastp_CBE
38.97
32%
26
- C1 -
-
6G78
1
KS6A6_HUMAN
A:
[13-288]
------
I
P
I
T
H
H
V
--
K
E
G
Y
E
---
K
A
D
---
P
A
Q
FELLK
V
L
G
Q
G
S
F
G
KVF
L
V
R
K
K
T
G
P
D
A
G
Q
L
Y
A
M
K
V
L
K
---
K
---------
A
S
L
K
V
R
D
----------------
D
I
L
V
-
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
-
R
L
S
K
E
-
V
----
L
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
E
----
I
---
G
---
H
---
I
K
L
T
D
F
G
L
S
K
---
E
S
V
-
D
-
Q
-------------
G
T
V
E
Y
M
A
P
E
V
V
-------
N
R
R
G
H
-
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
------
Q
-
G
K
D
-----
R
N
-
E
-------
T
M
N
M
I
L
K
A
--
K
L
G
M
P
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
EGV
E
E
I
K
R
H
L
F
----------
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
38.96
32%
21
- C1 -
-
6G78
1
KS6A6_HUMAN
B:
[13-288]
------
I
P
I
T
H
H
V
--
K
E
G
Y
E
---
K
A
D
---
P
A
Q
FELLK
V
L
G
Q
G
S
F
G
KVF
L
V
R
K
K
T
G
P
D
A
G
Q
L
Y
A
M
K
V
L
K
---
K
---------
A
S
L
K
V
R
D
----------------
D
I
L
V
-
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
-
R
L
S
K
E
-
V
----
L
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
E
----
I
---
G
---
H
---
I
K
L
T
D
F
G
L
S
K
---
E
S
V
-----------------
G
T
V
E
Y
M
A
P
E
V
V
-------
N
R
R
G
H
-
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
------
Q
-
G
K
D
-----
R
N
-
E
-------
T
M
N
M
I
L
K
A
--
K
L
G
M
P
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
EGV
E
E
I
K
R
H
L
F
----------
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
37.91
35%
5
- C1 -
-
3KN5
1
KS6A5_HUMAN
A:
[6-262]
-----------------
F
Y
Q
---
H
Y
D
LDL
K
D
K
-----
P
L
G
E
G
S
F
S
---
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
S
------------------
K
R
M
--
E
--
A
N
--
T
Q
K
-
E
I
T
A
L
K
-
L
C
E
-
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
-
R
I
K
K
K
-
K
----
H
--
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
F
TD---------------
L
---
E
---
I
K
I
I
D
F
G
F
A
----
R
-
L
-
K
-
P
P--------------------------------
N
G
Y
-
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
------
Q
-------------CTSAVE-
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
Blastp_CBE
36.88
38%
-16
- C1 -
-
2J90
2
DAPK3_HUMAN
A:
[26-293]
-------------------
D
---
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
K
KRR
L
---
S
S
R
R
G
V
S
R
E
E
I
E
-------------
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
-
E
----
S
--
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
KNVP
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
-
A
--------------
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
I
A
----
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
I
-----------
R
------------
R
------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
36.48
32%
16
- C1 -
-
6G76
1
KS6A6_HUMAN
B:
[13-288]
------
I
P
I
T
H
H
V
--
K
E
G
Y
E
---
K
A
D
---
P
A
Q
FELLK
V
L
G
Q
G
S
F
G
KVF
L
V
R
K
K
T
G
P
D
A
G
Q
L
Y
A
M
K
V
L
K
---
K
---------
A
S
L
K
V
-----------------
R
D
I
L
V
-
E
V
N
--
H
P
F
I
V
K
L
H
Y
A
F
Q
T
--
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
-
R
L
S
K
E
-
V
----
L
--
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
-
L
---
L
----
D
---
E
----
I
---
G
---
H
---
I
K
L
T
D
F
G
L
S
K
---
E
-
S
-
V
-
D
---------------
V
E
Y
M
A
P
E
V
V
-------
N
R
R
G
H
-
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
------
Q
-
G
K
D
-----
R
N
-
E
-------
T
----------
L
G
M
P
Q
F
--
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
L
G
S
EGV
E
E
I
K
R
H
L
F
----------
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
35.70
35%
16
- C1 -
-
3KN5
1
B:
[6-262]
-----------------
F
Y
Q
---
H
Y
D
LDL
K
D
K
-----
P
L
G
E
G
S
F
S
---
I
C
R
K
C
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
S
------------------
K
R
M
--
E
--
A
N
--
T
Q
K
-
E
I
T
A
L
K
-
L
C
E
-
G
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
-
R
I
K
K
K
-
K
----
H
--
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
V
G
V
V
H
R
D
L
K
P
E
N
L
-
L
---
F
TD---------------
L
---
E
---
I
K
I
I
D
F
G
F
A
----
R
-
L
-
K
-
P
P--------------------------------
N
G
Y
-
D
E
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
------
Q
-
S
H
D
-----
R
S
-
L
TCTSAVE
I
M
K
K
I
K
K
G
D
F
S
F
E
G
E
A
W
K
N
V
S
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
35.27
38%
-5
- C1 -
-
2J90
3
DAPK3_HUMAN
B:
[27-295]
-----------------------
H
Y
E
---
M
G
E
-----
E
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
----
K
E
Y
A
A
K
F
I
K
KRR
L
---
S
S
R
R
G
V
S
R
E
E
I
E
-------------
R
-
E
V
N
I
L
R
-
E
I
R
--
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
-
E
-------
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
K
R
I
A
H
F
D
L
K
P
E
N
I
-
M
---
L
----
L
---
D
KNVP
N
---
P
---
R
---
I
K
L
I
D
F
G
I
A
H
---
K
-
I
-
E
-
A
-
G
N
-
E
F
K
--
N
I
-
F
G
T
P
E
F
V
A
P
E
I
V
-------
N
Y
E
P
L
-
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
------
L
-
G
E
T
-----
K
Q
-
E
-------
T
L
T
N
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
M
I
A
----
Q
S
L
E
H
S
W
----------
I
-----------
K
------------
A
I
-----------
R
------------
R
-----------
R
---------------
N
--------------------------------------------------------------------------------------------