@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PLK1_HUMAN: (2020-09-19 )
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFFEDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
Atome Classification :
(296 SA)
.........10........20........30........40--.........---50--.------...-----....60....---...---.70--.........80...-....-.90-...----.....-100.......-110.......120.......130.......140........150.......160.......-170.......180..---..----...---190.......200-......-..-210.......220.------.....-.230........240.......250-..-----....--..260-........270---.----...--....280.......290.-----.-----.....300..---.-....310....-...320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEI---PEVLVDPRS---RR--R------YVR-----GRFLGKGGFA---KCF---EI---SDADTKEVFAGKIV-PKSL-LLK-PHQ----REKMS-MEISIHRSLA-HQHVVGFHGFFEDNDFVFVVLELCRRRSLLE-LHKRRKALTEPEARYYLRQIVLGCQYLHR-NRVIHRDLKLGNLFL---NE----DLE---VKIGDFGLATKV--EYDGER-KK-TLCGTPNYIAPEVL------SKKGH-SF-EVDVWSIGCIMYTLLVGKPPF--ET-----SCLK--ETYL--RIKKNEYSIP----K----HIN--PVAASLIQKMLQTDPTAR-----P-----TINELLNDEF---F-TSGYIPARLPI-TCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLKYFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRLKAS
4
PsiBlast_PDB
94.83
99%
-134
- C1 -
-
2OU7
1
PLK1_HUMAN
A:
[27-318]
------------------------------------
A
K
E
I
---
P
E
V
L
V
D
P
R
S
---
R
R
--
R
------
Y
V
R
-----
G
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F
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---
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---
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---
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----
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M
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D
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L
E
-
L
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A
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E
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-
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-
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A
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------
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I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
94.46
99%
-136
- C1 -
-
4J52
1
PLK1_HUMAN
A:
[1-293]
-------------------------------------
K
E
I
---
P
E
V
L
V
D
P
R
S
---
R
R
--
R
------
Y
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-----
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A
---
K
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---
E
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---
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F
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F
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L
E
-
L
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K
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R
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P
E
A
R
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Y
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N
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----
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--
E
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R
-
K
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-
V
L
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G
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P
N
Y
I
A
P
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V
L
------
S
K
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-
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F
-
E
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--
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P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
94.43
99%
-136
- C1 -
-
2OWB
1
PLK1_HUMAN
A:
[27-320]
------------------------------------
A
K
E
I
---
P
E
V
L
V
D
P
R
S
---
R
R
--
R
------
Y
V
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
F
---
E
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---
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----
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-
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A
R
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Y
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N
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---
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L
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G
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--
E
Y
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E
R
-
K
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-
V
L
C
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P
N
Y
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A
P
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V
L
------
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K
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G
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-
S
F
-
E
V
D
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--
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--
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A
A
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---
F
-
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I
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A
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S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
94.42
99%
-132
- C1 -
-
5TA8
1
PLK1_HUMAN
A:
[50-343]
------------------------------------
A
K
E
I
---
P
E
V
L
V
D
P
R
S
---
R
R
--
R
------
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-----
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K
G
G
F
A
---
K
C
F
---
E
I
---
S
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A
D
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F
A
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K
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-
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----
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M
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-
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R
R
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L
L
E
-
L
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K
A
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P
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R
Y
Y
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-
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A
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-
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L
------
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---
F
-
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I
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---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
94.26
99%
-133
- C1 -
-
4J53
1
PLK1_HUMAN
A:
[1-293]
-------------------------------------
K
E
I
---
P
E
V
L
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P
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---
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------
Y
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A
---
K
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A
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N
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F
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F
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V
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C
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R
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S
L
L
E
-
L
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A
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P
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A
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C
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Y
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-
N
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---
F
-
T
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Y
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A
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P
I
-
T
C
L
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R
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S
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A
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
93.68
99%
-127
- C1 -
-
5TA6
1
PLK1_HUMAN
A:
[50-343]
------------------------------------
A
K
E
I
---
P
E
V
L
V
D
P
R
S
---
R
R
--
R
------
Y
V
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-----
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K
G
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A
---
K
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---
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K
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----
R
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N
D
F
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F
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V
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R
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L
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E
-
L
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A
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E
A
R
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Y
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Y
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S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
584
HHSearch
93.46
100%
-135
- C1 -
-
4J53
1
PLK1_HUMAN
A:
[4-290]
-------------------------------------------
P
E
V
L
V
D
P
R
S
---
R
R
--
R
------
Y
V
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
F
---
E
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---
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D
A
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K
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K
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----
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A
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Q
H
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F
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G
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N
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E
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C
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S
L
L
E
-
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
---
N
E
----
D
L
E
---
V
K
I
G
D
F
G
L
A
T
K
V
--
E
Y
D
G
E
R
-
K
K
-
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
------
S
K
K
G
H
-
S
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
--
E
T
-----
S
C
L
K
--
E
T
Y
L
--
R
I
K
K
N
E
Y
S
I
P
----
K
----
H
I
N
--
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
-----
P
-----
T
I
N
E
L
L
N
D
E
F
---
F
-
T
S
G
Y
I
P
A
R
L
P
I
-
T
C
L
T
I
P
P
R
F
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
93.37
100%
-131
- C1 -
-
2YAC
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------
E
I
---
P
E
V
L
V
D
P
R
S
---
R
R
--
R
------
Y
V
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
F
---
E
I
---
S
D
A
D
T
K
E
V
F
A
G
K
I
V
-
P
K
S
L
-
L
L
K
-
P
H
Q
----
R
E
K
M
S
-
M
E
I
S
I
H
R
S
L
A
-
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
---
N
E
----
D
L
E
---
V
K
I
G
D
F
G
L
A
T
K
V
--
E
Y
D
G
E
R
-
K
K
-
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
------
S
K
K
G
H
-
S
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
--
E
T
-----
S
C
L
K
--
E
T
Y
L
--
R
I
K
K
N
E
Y
S
I
P
----
K
----
H
I
N
--
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
-----
P
-----
T
I
N
E
L
L
N
D
E
F
---
F
-
T
S
G
Y
I
P
A
R
L
P
I
-
T
C
L
T
I
P
P
R
F
S
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
92.84
100%
-131
- C1 -
-
4A4L
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------
E
I
---
P
E
V
L
V
D
P
R
S
---
R
R
--
R
------
Y
V
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
F
---
E
I
---
S
D
A
D
T
K
E
V
F
A
G
K
I
V
-
P
K
S
L
-
L
L
K
-
P
H
Q
----
R
E
K
M
S
-
M
E
I
S
I
H
R
S
L
A
-
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
---
N
E
----
D
L
E
---
V
K
I
G
D
F
G
L
A
T
K
V
--
E
Y
D
G
E
R
-
K
K
-
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
------
S
K
K
G
H
-
S
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
--
E
T
-----
S
C
L
K
--
E
T
Y
L
--
R
I
K
K
N
E
Y
S
I
P
----
K
----
H
I
N
--
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
-----
P
-----
T
I
N
E
L
L
N
D
E
F
---
F
-
T
S
G
Y
I
P
A
R
L
P
I
-
T
C
L
T
I
P
P
R
F
S
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
583
HHSearch
92.53
100%
-135
- C1 -
-
2RKU
6
PLK1_HUMAN
A:
[3-291]
--------------------------------------
E
I
---
P
E
V
L
V
D
P
R
S
---
R
R
--
R
------
Y
V
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
F
---
E
I
---
S
D
A
D
T
K
E
V
F
A
G
K
I
V
-
P
K
S
L
-
L
L
K
-
P
H
Q
----
R
E
K
M
S
-
M
E
I
S
I
H
R
S
L
A
-
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
---
N
E
----
D
L
E
---
V
K
I
G
D
F
G
L
A
T
K
V
--
E
Y
D
G
E
R
-
K
K
-
V
L
C
G
T
P
N
Y
I
A
P
E
V
L
------
S
K
K
G
H
-
S
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
--
E
T
-----
S
C
L
K
--
E
T
Y
L
--
R
I
K
K
N
E
Y
S
I
P
----
K
----
H
I
N
--
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
-----
P
-----
T
I
N
E
L
L
N
D
E
F
---
F
-
T
S
G
Y
I
P
A
R
L
P
I
-
T
C
L
T
I
P
P
R
F
S
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
92.45
100%
-127
- C1 -
-
4A4O
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------
E
I
---
P
E
V
L
V
D
P
R
S
---
R
R
--
R
------
Y
V
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
F
---
E
I
---
S
D
A
D
T
K
E
V
F
A
G
K
I
V
-
P
K
S
L
-
L
L
K
-
P
H
Q
----
R
E
K
M
S
-
M
E
I
S
I
H
R
S
L
A
-
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
---
N
E
----
D
L
E
---
V
K
I
G
D
F
G
L
A
T
K
V
--
E
Y
D
G
E
R
-
K
K
-
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
------
S
K
K
G
H
-
S
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
--
E
T
-----
S
C
L
K
--
E
T
Y
L
--
R
I
K
K
N
E
Y
S
I
P
----
K
----
H
I
N
--
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
-----
P
-----
T
I
N
E
L
L
N
D
E
F
---
F
-
T
S
G
Y
I
P
A
R
L
P
I
-
T
C
L
T
I
P
P
R
F
S
I
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
92.09
99%
-132
- C1 -
-
3KB7
2
PLK1_HUMAN
A:
[5-294]
--------------------------------------
E
I
---
P
E
V
L
V
D
P
R
S
---
R
R
--
R
------
Y
V
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
F
---
E
I
---
S
D
A
D
T
K
E
V
F
A
G
K
I
V
-
P
K
S
L
-
L
L
K
-
P
H
Q
----
R
E
K
M
S
-
M
E
I
S
I
H
R
S
L
A
-
H
Q
H
V
V
G
F
H
G
F
F
E
D
N
D
F
V
F
V
V
L
E
L
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
L
T
E
P
E
A
R
Y
Y
L
R
Q
I
V
L
G
C
Q
Y
L
H
R
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
---
N
E
----
D
L
E
---
V
K
I
G
D
F
G
L
A
T
K
V
--
E
Y
D
G
E
R
-
K
K
-
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
------
S
K
K
G
H
-
S
F
-
E
V
D
V
W
S
I
G
C
I
M
Y
T
L
L
V
G
K
P
P
F
--
E
T
-----
S
C
L
K
--
E
T
Y
L
--
R
I
K
K
N
E
Y
S
I
P
----
K
----
H
I
N
--
P
V
A
A
S
L
I
Q
K
M
L
Q
T
D
P
T
A
R
-----
P
-----
T
I
N
E
L
L
N
D
E
F
---
F
-
T
S
G
Y
I
P
A
R
L
P
I
-
T
C
L
T
I
P
P
N
F
S
I
A
P
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
83.19
79%
-126
- C1 -
-
3D5X
1
?
A:
[13-298]
-------------------------------------
K
E
I
---
P
D
V
L
V
D
P
R
T
---
M
K
--
R
------
Y
M
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
Y
---
E
I
---
T
D
M
D
T
K
E
V
F
A
G
K
V
V
-
P
K
S
M
-
L
L
K
-
P
H
Q
----
K
E
-
M
S
-
T
E
I
A
I
H
K
S
L
D
-
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
---
N
D
----
D
M
D
---
V
K
I
G
D
F
G
L
A
T
K
I
--
E
F
D
G
E
R
-
K
K
-
D
-------
I
A
P
E
V
L
------
C
K
K
G
H
-
S
F
-
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
--
E
T
-----
S
C
L
K
--
E
T
Y
I
--
R
I
K
K
N
E
Y
S
V
P
----
R
----
H
I
N
--
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
-----
P
-----
S
V
A
E
L
L
T
D
E
F
---
F
-
T
S
G
Y
A
P
M
R
L
P
T
-
S
C
L
T
V
P
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
82.58
77%
-121
- C1 -
-
3D5W
1
?
A:
[29-315]
-------------------------------------
K
E
I
---
P
D
V
L
V
D
P
R
T
---
M
K
--
R
------
Y
M
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
Y
---
E
I
---
T
D
M
D
T
K
E
V
F
A
G
K
V
V
-
P
K
S
M
-
L
---
P
H
Q
----
K
E
K
M
S
-
T
E
I
A
I
H
K
S
L
D
-
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
---
N
D
----
D
M
D
---
V
K
I
G
D
F
G
L
A
T
K
I
--
E
F
D
G
E
R
-
K
K
-
T
L
C
G
T
P
N
Y
I
A
P
E
V
L
------
C
K
K
G
H
-
S
F
-
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
--
E
T
-----
S
C
L
K
--
E
T
Y
I
--
R
I
K
K
N
E
Y
S
V
P
----
R
----
H
I
N
--
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
-----
P
-----
S
V
A
E
L
L
T
D
E
F
---
F
-
T
S
G
Y
A
P
M
R
L
P
T
-
S
C
L
T
V
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
81.76
79%
-118
- C1 -
-
3DBE
1
?
A:
[13-299]
-------------------------------------
K
E
I
---
P
D
V
L
V
D
-
R
T
---
M
K
--
R
------
Y
M
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
Y
---
E
I
---
T
D
M
D
T
K
E
V
F
A
G
K
V
V
-
P
K
S
M
-
L
L
K
-
P
H
Q
----
K
E
K
M
S
-
T
E
I
A
I
H
K
S
L
D
-
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
---
N
D
----
D
M
D
---
V
K
I
G
D
F
G
L
A
T
K
I
--
E
F
D
G
E
R
-
K
K
-
D
L
---
P
N
Y
I
A
P
E
V
L
------
C
K
K
G
H
-
S
F
-
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
--
E
T
-----
S
C
L
K
--
E
T
Y
I
--
R
I
K
K
N
E
Y
S
V
P
----
R
----
H
I
N
--
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
-----
P
-----
S
V
A
E
L
L
T
D
E
F
---
F
-
T
S
G
Y
A
P
M
R
L
P
T
-
S
C
L
T
V
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
78.62
76%
-136
- C1 -
-
3DB8
1
?
A:
[29-315]
-------------------------------------
K
E
I
---
P
D
V
L
V
D
P
R
T
---
M
K
--
R
------
Y
M
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
Y
---
E
I
---
T
D
M
D
T
K
E
V
F
A
G
K
V
V
-
P
K
S
M
-
L
L
K
-
P
H
Q
----
K
E
K
M
S
-
T
E
I
A
I
H
K
S
L
D
-
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
---
N
D
----
D
M
D
---
V
K
I
G
D
F
G
L
A
T
K
I
------------------------------------
H
-
S
F
-
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
--
E
T
-----
S
C
L
K
--
E
T
Y
I
--
R
I
K
K
N
E
Y
S
V
P
----
R
----
H
I
N
--
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
-----
P
-----
S
V
A
E
L
L
T
D
E
F
---
F
-
T
S
G
Y
A
P
M
R
L
P
T
-
S
C
L
T
V
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
78.48
76%
-138
- C1 -
-
3DBD
1
?
A:
[29-315]
-------------------------------------
K
E
I
---
P
D
V
L
V
D
P
R
T
---
M
K
--
R
------
Y
M
R
-----
G
R
F
L
G
K
G
G
F
A
---
K
C
Y
---
E
I
---
T
D
M
D
T
K
E
V
F
A
G
K
V
V
-
P
K
S
M
-
L
L
K
-
P
H
Q
----
K
E
K
M
S
-
T
E
I
A
I
H
K
S
L
D
-
N
P
H
V
V
G
F
H
G
F
F
E
D
D
D
F
V
Y
V
V
L
E
I
C
R
R
R
S
L
L
E
-
L
H
K
R
R
K
A
V
T
E
P
E
A
R
Y
F
M
R
Q
T
I
Q
G
V
Q
Y
L
H
N
-
N
R
V
I
H
R
D
L
K
L
G
N
L
F
L
---
N
D
----
D
M
D
---
V
K
I
G
D
F
G
L
A
T
K
I
------------------------------------
H
-
S
F
-
E
V
D
I
W
S
L
G
C
I
L
Y
T
L
L
V
G
K
P
P
F
--
E
T
-----
S
C
L
K
--
E
T
Y
I
--
R
I
K
K
N
E
Y
S
V
P
----
R
----
H
I
N
--
P
V
A
S
A
L
I
R
R
M
L
H
A
D
P
T
L
R
-----
P
-----
S
V
A
E
L
L
T
D
E
F
---
F
-
T
S
G
Y
A
P
M
R
L
P
T
-
S
C
L
T
V
P
P
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
75.67
51%
-124
- C1 -
-
4I6B
1
PLK2_HUMAN
A:
[19-303]
--------------------------------------------
R
I
I
V
D
P
T
T
---
G
K
--
R
------
Y
S
R
-----
G
K
T
L
G
K
G
G
F
A
---
K
C
Y
---
E
M
---
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
-
P
H
S
R
-
V
S
K
-
P
H
Q
----
R
E
K
I
D
-
K
E
I
E
L
H
R
I
L
H
-
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
-
I
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
---
N
E
----
S
M
E
---
L
K
V
G
D
F
G
L
A
A
R
L
--
E
P
L
E
H
R
-
R
R
-
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
------
N
K
Q
G
H
-
G
A
-
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
--
E
T
-----
T
N
L
K
--
E
T
Y
R
--
S
I
R
E
A
R
Y
T
M
P
----
S
----
S
L
L
--
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
-----
P
-----
S
L
D
D
I
I
R
H
D
F
---
F
-
T
Q
G
F
T
P
D
R
L
S
S
-
S
C
C
H
T
V
P
D
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
586
HHSearch
75.23
52%
-127
- C1 -
-
4I6H
1
PLK2_HUMAN
A:
[19-298]
--------------------------------------------
R
I
I
V
D
P
T
T
---
G
K
--
R
------
Y
S
R
-----
G
K
T
L
G
K
G
G
F
A
---
K
C
Y
---
E
M
---
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
-
P
H
S
R
-
V
S
K
-
P
H
Q
----
R
E
K
I
D
-
K
E
I
E
L
H
R
I
L
H
-
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
-
I
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
---
N
E
----
S
M
E
---
L
K
V
G
D
F
G
L
A
A
R
L
--
E
P
L
E
H
R
-
R
R
-
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
------
N
K
Q
G
H
-
G
A
-
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
--
E
T
-----
T
N
L
K
--
E
T
Y
R
--
S
I
R
E
A
R
Y
T
M
P
----
S
----
S
L
L
--
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
-----
P
-----
S
L
D
D
I
I
R
H
D
F
---
F
-
T
Q
G
F
T
P
D
R
L
S
S
-
S
C
C
H
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
74.84
51%
-123
- C1 -
-
4I6F
1
PLK2_HUMAN
A:
[19-303]
--------------------------------------------
R
I
I
V
D
P
T
T
---
G
K
--
R
------
Y
S
R
-----
G
K
T
L
G
K
G
G
F
A
---
K
C
Y
---
E
M
---
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
-
P
H
S
R
-
V
S
K
-
P
H
Q
----
R
E
K
I
D
-
K
E
I
E
L
H
R
I
L
H
-
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
-
I
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
---
N
E
----
S
M
E
---
L
K
V
G
D
F
G
L
A
A
R
L
--
E
P
L
E
H
R
-
R
R
-
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
------
N
K
Q
G
H
-
G
A
-
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
--
E
T
-----
T
N
L
K
--
E
T
Y
R
--
S
I
R
E
A
R
Y
T
M
P
----
S
----
S
L
L
--
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
-----
P
-----
S
L
D
D
I
I
R
H
D
F
---
F
-
T
Q
G
F
T
P
D
R
L
S
S
-
S
C
C
H
T
V
P
D
F
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
585
HHSearch
74.38
52%
-126
- C1 -
-
4I5P
1
PLK2_HUMAN
A:
[19-298]
--------------------------------------------
R
I
I
V
D
P
T
T
---
G
K
--
R
------
Y
S
R
-----
G
K
T
L
G
K
G
G
F
A
---
K
C
Y
---
E
M
---
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
-
P
H
S
R
-
V
S
K
-
P
H
Q
----
R
E
K
I
D
-
K
E
I
E
L
H
R
I
L
H
-
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
-
I
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
---
N
E
----
S
M
E
---
L
K
V
G
D
F
G
L
A
A
R
L
--
E
P
L
E
H
R
-
R
R
-
T
I
C
G
T
P
N
Y
L
S
P
E
V
L
------
N
K
Q
G
H
-
G
A
-
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
--
E
T
-----
T
N
L
K
--
E
T
Y
R
--
S
I
R
E
A
R
Y
T
M
P
----
S
----
S
L
L
--
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
-----
P
-----
S
L
D
D
I
I
R
H
D
F
---
F
-
T
Q
G
F
T
P
D
R
L
S
S
-
S
C
C
H
T
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
73.99
54%
-124
- C1 -
-
4B6L
1
PLK3_HUMAN
A:
[1-281]
---------------------------------------------
L
I
T
D
P
R
S
---
G
R
--
T
------
Y
L
K
-----
G
R
L
L
G
K
G
G
F
A
---
R
C
Y
---
E
A
---
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
-
P
Q
S
R
-
V
A
K
-
P
H
Q
----
R
E
K
I
L
-
N
E
I
E
L
H
R
D
L
Q
-
H
R
H
I
V
R
F
S
H
H
F
E
D
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
-
I
W
K
A
R
H
T
L
L
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
-
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
---
T
E
----
N
M
E
---
L
K
V
G
D
F
G
L
A
A
R
L
--
E
P
P
E
Q
R
-
K
K
-
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
------
L
R
Q
G
H
-
G
P
-
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
--
E
T
-----
A
D
L
K
--
E
T
Y
R
--
C
I
K
Q
V
H
Y
T
L
P
----
A
----
S
L
S
--
L
P
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
-----
P
-----
S
I
D
Q
I
L
R
H
D
F
---
F
-
T
K
G
Y
T
P
D
R
L
P
I
S
S
C
V
T
V
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
587
HHSearch
73.95
54%
-121
- C1 -
-
4B6L
1
PLK3_HUMAN
A:
[4-275]
------------------------------------------------
D
P
R
S
---
G
R
--
T
------
Y
L
K
-----
G
R
L
L
G
K
G
G
F
A
---
R
C
Y
---
E
A
---
T
D
T
E
T
G
S
A
Y
A
V
K
V
I
-
P
Q
S
R
-
V
A
K
-
P
H
Q
----
R
E
K
I
L
-
N
E
I
E
L
H
R
D
L
Q
-
H
R
H
I
V
R
F
S
H
H
F
E
D
A
D
N
I
Y
I
F
L
E
L
C
S
R
K
S
L
A
H
-
I
W
K
A
R
H
T
L
L
E
P
E
V
R
Y
Y
L
R
Q
I
L
S
G
L
K
Y
L
H
Q
-
R
G
I
L
H
R
D
L
K
L
G
N
F
F
I
---
T
E
----
N
M
E
---
L
K
V
G
D
F
G
L
A
A
R
L
--
E
P
P
E
Q
R
-
K
K
-
T
I
C
G
T
P
N
Y
V
A
P
E
V
L
------
L
R
Q
G
H
-
G
P
-
E
A
D
V
W
S
L
G
C
V
M
Y
T
L
L
C
G
S
P
P
F
--
E
T
-----
A
D
L
K
--
E
T
Y
R
--
C
I
K
Q
V
H
Y
T
L
P
----
A
----
S
L
S
--
L
P
A
R
Q
L
L
A
A
I
L
R
A
S
P
R
D
R
-----
P
-----
S
I
D
Q
I
L
R
H
D
F
---
F
-
T
K
G
Y
T
P
D
R
L
P
I
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
72.81
51%
-126
- C1 -
-
4I5M
1
PLK2_HUMAN
A:
[19-302]
--------------------------------------------
R
I
I
V
D
P
T
T
---
G
K
--
R
------
Y
S
R
-----
G
K
T
L
G
K
G
G
F
A
---
K
C
Y
---
E
M
---
T
D
L
T
N
N
K
V
Y
A
A
K
I
I
-
P
H
S
R
-
V
S
K
-
P
H
Q
----
R
E
K
I
D
-
K
E
I
E
L
H
R
I
L
H
-
H
K
H
V
V
Q
F
Y
H
Y
F
E
D
K
E
N
I
Y
I
L
L
E
Y
C
S
R
R
S
M
A
H
-
I
L
K
A
R
K
V
L
T
E
P
E
V
R
Y
Y
L
R
Q
I
V
S
G
L
K
Y
L
H
E
-
Q
E
I
L
H
R
D
L
K
L
G
N
F
F
I
---
N
E
----
S
M
E
---
L
K
V
G
D
F
G
L
A
A
R
L
--
E
-------------
T
P
N
Y
L
S
P
E
V
L
------
N
K
Q
G
H
-
G
A
-
E
S
D
I
W
A
L
G
C
V
M
Y
T
M
L
L
G
R
P
P
F
--
E
T
-----
T
N
L
K
--
E
T
Y
R
--
S
I
R
E
A
R
Y
T
M
P
----
S
----
S
L
L
--
A
P
A
K
H
L
I
A
S
M
L
S
K
N
P
E
D
R
-----
P
-----
S
L
D
D
I
I
R
H
D
F
---
F
-
T
Q
G
F
T
P
D
R
L
S
S
-
S
C
C
H
T
V
P
D
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
61.01
34%
-138
- C1 -
-
4UMP
1
MELK_HUMAN
C:
[34-287]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
----
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
K
----------------
G
A
L
A
Y
A
A
P
E
L
I
------
Q
G
K
---
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
T
A
A
--
A
L
V
A
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
60.83
34%
-131
- C1 -
-
4UMP
1
MELK_HUMAN
B:
[37-287]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
G
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
K
P
--
K
G
N
K
D
-------
C
G
A
L
A
Y
A
A
P
E
L
I
------
Q
G
K
---
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
T
A
A
--
A
L
V
A
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
60.35
34%
-143
- C1 -
-
4D2T
1
MELK_HUMAN
A:
[37-287]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-----
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
---------------
A
C
C
G
A
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
--
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
T
A
A
--
A
L
V
A
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
60.17
34%
-134
- C1 -
-
5DR9
2
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
---------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
60.09
34%
-124
- C1 -
-
3UO5
1
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
60.06
35%
-138
- C1 -
-
4BL1
1
MELK_HUMAN
A:
[18-268]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
----
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
---
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
60.05
34%
-121
- C1 -
-
3UOD
3
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
59.84
34%
-122
- C1 -
-
4JAJ
1
AURKA_HUMAN
A:
[24-273]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
T
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
59.75
34%
-138
- C1 -
-
4UMP
1
MELK_HUMAN
A:
[37-287]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-----
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
-----------------
G
A
L
A
Y
A
A
P
E
L
I
------
Q
G
K
---
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
T
A
A
--
A
L
V
A
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
59.41
31%
-114
- C1 -
-
2F7Z
1
KAPCA_BOVIN
E:
[43-300]
-----------------------------------------------------------
Q
------
F
E
R
-----
I
K
T
L
G
T
G
S
F
G
---
R
V
M
---
L
V
---
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
-
D
K
Q
K
-
V
V
K
-
L
K
Q
----
I
E
H
T
L
-
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
----
Q
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
---
G
R
-
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
S
K
G
Y
-
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
A
-----
D
Q
P
I
--
Q
I
Y
E
--
K
I
V
S
G
K
V
R
F
P
----
S
----
H
F
S
--
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
---
F
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
59.38
34%
-133
- C1 -
-
4C3P
1
AURKA_HUMAN
A:
[15-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
T
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
59.36
34%
-123
- C1 -
-
5DR2
2
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
A
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
59.25
33%
-134
- C1 -
-
3K5U
1
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
-----------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
59.25
34%
-130
- C1 -
-
2X6D
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
---------
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
59.13
31%
-103
- C1 -
-
2F7X
1
KAPCA_BOVIN
E:
[43-300]
-----------------------------------------------------------
Q
------
F
E
R
-----
I
K
T
L
G
T
G
S
F
G
---
R
V
M
---
L
V
---
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
-
D
K
Q
K
-
V
V
K
-
L
K
Q
----
I
E
H
T
L
-
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
----
Q
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
---
G
R
-
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
S
K
G
Y
-
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
A
-----
D
Q
P
I
--
Q
I
Y
E
--
K
I
V
S
G
K
V
R
F
P
----
S
----
H
F
S
--
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
---
F
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
59.09
31%
-108
- C1 -
-
2OJF
1
KAPCA_BOVIN
E:
[43-300]
-----------------------------------------------------------
Q
------
F
E
R
-----
I
K
T
L
G
T
G
S
F
G
---
R
V
M
---
L
V
---
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
-
D
K
Q
K
-
V
V
K
-
L
K
Q
----
I
E
H
T
L
-
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
----
Q
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
---
G
R
-
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
S
K
G
Y
-
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
A
-----
D
Q
P
I
--
Q
I
Y
E
--
K
I
V
S
G
K
V
R
F
P
----
S
----
H
F
S
--
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
---
F
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
59.07
33%
-137
- C1 -
-
5ODT
4
AURKA_HUMAN
A:
[16-266]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
N
F
G
W
S
--
V
--
H
-----------
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
58.95
33%
-124
- C1 -
-
6R49
2
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
-----
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
58.92
35%
-137
- C1 -
-
4CQG
1
MELK_MOUSE
A:
[17-267]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
V
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
A
-
L
G
S
-
D
L
P
----
R
V
K
T
---
E
I
D
A
L
K
S
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
N
H
K
---
L
K
L
I
D
F
G
L
C
A
K
---------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
-----
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
E
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
R
N
L
L
N
H
P
W
---
V
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
58.92
33%
-130
- C1 -
-
2W1G
1
AURKA_HUMAN
A:
[16-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
------
H
A
---------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
58.88
35%
-134
- C1 -
-
4BFM
1
MELK_MOUSE
A:
[17-267]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
V
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
A
-
L
G
S
-
D
L
P
----
R
V
K
T
---
E
I
D
A
L
K
S
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
K
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
L
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
N
H
K
---
L
K
L
I
D
F
G
L
C
A
K
---------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
-----
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
E
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
R
N
L
L
N
H
P
W
---
V
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
58.84
35%
-144
- C1 -
-
5TWY
1
MELK_HUMAN
B:
[15-268]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
------
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
--------------------
L
A
Y
A
A
P
E
L
I
------
Q
G
K
---
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
58.80
31%
-112
- C1 -
-
2OH0
1
KAPCA_BOVIN
E:
[43-300]
-----------------------------------------------------------
Q
------
F
E
R
-----
I
K
T
L
G
T
G
S
F
G
---
R
V
M
---
L
V
---
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
-
D
K
Q
K
-
V
V
K
-
L
K
Q
----
I
E
H
T
L
-
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
----
Q
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
---
G
R
-
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
S
K
G
Y
-
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
A
-----
D
Q
P
I
--
Q
I
Y
E
--
K
I
V
S
G
K
V
R
F
P
----
S
----
H
F
S
--
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
---
F
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
58.77
34%
-147
- C1 -
-
6C2R
1
AURKA_HUMAN
A:
[17-266]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
----------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
58.69
31%
-112
- C1 -
-
2UZU
1
KAPCA_BOVIN
E:
[28-285]
-----------------------------------------------------------
Q
------
F
E
R
-----
I
K
T
L
G
T
G
S
F
G
---
R
V
M
---
L
V
---
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
-
D
K
Q
K
-
V
V
K
-
L
K
Q
----
I
E
H
T
L
-
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
----
Q
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
---
G
R
-
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
S
K
G
Y
-
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
A
-----
D
Q
P
I
--
Q
I
Y
E
--
K
I
V
S
G
K
V
R
F
P
----
S
----
H
F
S
--
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
FGNLK
D
-----
G
V
N
D
I
K
N
H
K
W
---
F
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
58.66
35%
-143
- C1 -
-
4BKY
1
MELK_HUMAN
A:
[18-268]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
---
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
---
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
58.60
31%
-105
- C1 -
-
2UZW
1
KAPCA_BOVIN
E:
[28-285]
-----------------------------------------------------------
Q
------
F
E
R
-----
I
K
T
L
G
T
G
S
F
G
---
R
V
M
---
L
V
---
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
-
D
K
Q
K
-
V
V
K
-
L
K
Q
----
I
E
H
T
L
-
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
----
Q
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
---
G
R
-
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
S
K
G
Y
-
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
A
-----
D
Q
P
I
--
Q
I
Y
E
--
K
I
V
S
G
K
V
R
F
P
----
S
----
H
F
S
--
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
FGNLK
D
-----
G
V
N
D
I
K
N
H
K
W
---
F
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
58.59
34%
-117
- C1 -
-
4DEE
1
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
58.57
34%
-133
- C1 -
-
2W1D
1
AURKA_HUMAN
A:
[16-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
---------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
--
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
58.56
31%
-112
- C1 -
-
2UZT
1
KAPCA_BOVIN
A:
[28-285]
-----------------------------------------------------------
Q
------
F
E
R
-----
I
K
T
L
G
T
G
S
F
G
---
R
V
M
---
L
V
---
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
-
D
K
Q
K
-
V
V
K
-
L
K
Q
----
I
E
H
T
L
-
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
----
Q
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
---
G
R
-
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
S
K
G
Y
-
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
A
-----
D
Q
P
I
--
Q
I
Y
E
--
K
I
V
S
G
K
V
R
F
P
----
S
----
H
F
S
--
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
FGNLK
D
-----
G
V
N
D
I
K
N
H
K
W
---
F
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
58.53
34%
-135
- C1 -
-
4D2P
1
MELK_HUMAN
A:
[37-287]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-----
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
-----------------
G
A
L
A
Y
A
A
P
E
L
I
------
Q
G
K
---
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
T
A
A
--
A
L
V
A
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
58.49
31%
-107
- C1 -
-
2F7E
1
KAPCA_BOVIN
E:
[43-300]
-----------------------------------------------------------
Q
------
F
E
R
-----
I
K
T
L
G
T
G
S
F
G
---
R
V
M
---
L
V
---
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
-
D
K
Q
K
-
V
V
K
-
L
K
Q
----
I
E
H
T
L
-
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
----
Q
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
---
G
R
-
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
S
K
G
Y
-
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
A
-----
D
Q
P
I
--
Q
I
Y
E
--
K
I
V
S
G
K
V
R
F
P
----
S
----
H
F
S
--
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
---
F
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
58.48
33%
-139
- C1 -
-
6HJJ
2
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
C
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
---------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
58.47
34%
-137
- C1 -
-
4ZTS
2
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
-------------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
161
Blastp_CBE
58.39
34%
-125
- C1 -
-
5DOS
2
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
-------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
58.34
34%
-139
- C1 -
-
4D2T
1
MELK_HUMAN
C:
[37-287]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
-----
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
K
----------------
G
A
L
A
Y
A
A
P
E
L
I
------
Q
G
K
---
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
T
A
A
--
A
L
V
A
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
58.34
33%
-124
- C1 -
-
5EW9
1
AURKA_HUMAN
A:
[17-266]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
-----
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
58.26
34%
-132
- C1 -
-
5OBJ
2
AURKA_HUMAN
A:
[17-266]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
58.24
33%
-135
- C1 -
-
5L8J
5
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
-------------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
58.23
33%
-129
- C1 -
-
3FDN
1
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
----------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
58.22
33%
-121
- C1 -
-
3W10
1
AURKA_HUMAN
A:
[11-261]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
A
-
A
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
58.14
34%
-129
- C1 -
-
5DPV
2
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
--------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
58.08
33%
-126
- C1 -
-
5OS2
2
AURKA_HUMAN
A:
[10-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
------
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
58.07
34%
-94
- C1 -
-
4UMP
1
MELK_HUMAN
D:
[37-291]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
G
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
K
P
--
K
G
N
K
D
--------
G
A
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
Y
L
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
T
A
A
--
A
L
V
A
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
57.88
34%
-141
- C1 -
-
4C3P
1
AURKA_HUMAN
D:
[15-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
--------
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
57.87
34%
-134
- C1 -
-
5DR6
2
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
---------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
57.87
34%
-123
- C1 -
-
4UZD
1
AURKA_HUMAN
B:
[13-263]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
-----------
R
-
R
T
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
57.86
35%
-117
- C1 -
-
4UMT
2
MELK_HUMAN
A:
[37-287]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
G
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
Y
L
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
T
A
A
--
A
L
V
A
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
57.79
34%
-100
- C1 -
-
6C9H
2
AAPK1_HUMAN
A:
[16-318]
------------------------------------------------------------------
Y
I
L
-----
G
D
T
L
G
V
G
T
F
G
---
K
V
K
---
V
G
---
K
H
E
L
T
G
H
K
V
A
V
K
I
L
-
N
R
Q
K
-
I
R
S
-
L
D
V
----
V
G
K
I
R
-
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
----
H
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
--
S
-
D
G
E
F
-
L
R
-
T
S
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
G
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-----
D
H
V
P
--
T
L
F
K
--
K
I
C
D
G
I
F
Y
T
P
----
Q
----
Y
L
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
57.76
33%
-138
- C1 -
-
3H0Y
1
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
-------------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
57.74
35%
-149
- C1 -
-
4BKZ
1
MELK_HUMAN
A:
[18-268]
-----------------------------------------------------------------------------
I
G
T
G
--
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
----
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
----
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
57.63
33%
-134
- C1 -
-
4O0W
1
AURKA_HUMAN
A:
[15-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
Y
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
----------
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
57.57
35%
-111
- C1 -
-
4UMU
1
MELK_HUMAN
A:
[37-287]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
G
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
Y
L
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
T
A
A
--
A
L
V
A
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
57.54
33%
-119
- C1 -
-
4DHF
1
AURKA_HUMAN
A:
[16-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
57.51
34%
-110
- C1 -
-
4UMR
1
MELK_HUMAN
A:
[37-287]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
G
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
Y
L
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
T
A
A
--
A
L
V
A
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
57.51
34%
-123
- C1 -
-
5DT0
1
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
-------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
57.51
34%
-134
- C1 -
-
3MYG
2
AURKA_HUMAN
A:
[17-266]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
-------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
57.51
34%
-114
- C1 -
-
4DED
4
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
57.47
33%
-131
- C1 -
-
5AAF
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
-----------
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
57.46
34%
-113
- C1 -
-
3UOJ
1
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
57.43
34%
-130
- C1 -
-
4C3R
1
AURKA_HUMAN
A:
[15-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
57.41
33%
-138
- C1 -
-
4PRJ
1
AURKA_HUMAN
A:
[14-263]
--------------------------------------------------------------------------
G
R
P
L
G
K
---
G
---
N
V
Y
---
L
A
---
R
E
K
N
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
S
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
K
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--------------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
D
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
57.41
34%
-113
- C1 -
-
3UOJ
1
AURKA_HUMAN
B:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
57.39
33%
-125
- C1 -
-
4DHF
1
AURKA_HUMAN
B:
[16-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
57.32
33%
-138
- C1 -
-
3D15
1
AURKA_MOUSE
A:
[17-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
T
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
N
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
---------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
--
E
A
-----
H
T
Y
Q
--
E
T
Y
R
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-----
L
-----
T
L
A
E
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
57.28
33%
-121
- C1 -
-
3H10
1
AURKA_HUMAN
B:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
A
-
A
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
57.26
34%
-133
- C1 -
-
2W1E
1
AURKA_HUMAN
A:
[16-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
---------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
57.25
33%
-128
- C1 -
-
1OL6
1
AURKA_HUMAN
A:
[15-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
-
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
------
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
N
F
G
W
S
--
V
--
H
-------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
-
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
57.22
34%
-147
- C1 -
-
2X81
1
AURKA_HUMAN
A:
[17-266]
--------------------------------------------------------------------------
G
R
P
L
G
---
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
-----------------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
57.12
34%
-123
- C1 -
-
4UZD
1
AURKA_HUMAN
A:
[13-263]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
------------
R
-
R
T
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
57.09
34%
-129
- C1 -
-
1MUO
1
AURKA_HUMAN
A:
[30-280]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
----------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
57.09
34%
-118
- C1 -
-
3UOL
6
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
57.07
34%
-117
- C1 -
-
3UOL
8
AURKA_HUMAN
B:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
56.87
33%
-134
- C1 -
-
2C6E
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
------------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
56.81
34%
-134
- C1 -
-
3O50
1
AURKA_HUMAN
B:
[12-261]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
----------------
T
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
-----
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
56.78
33%
-131
- C1 -
-
2C6E
1
AURKA_HUMAN
B:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
----------------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
56.77
34%
-114
- C1 -
-
3UOH
4
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
56.76
31%
-105
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[28-285]
-----------------------------------------------------------
Q
------
F
E
R
-----
I
K
T
L
G
T
G
S
F
G
---
R
V
M
---
L
V
---
K
H
M
E
T
G
N
H
Y
A
M
K
I
L
-
D
K
Q
K
-
V
V
K
-
L
K
Q
----
I
E
H
T
L
-
N
E
K
R
I
L
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
----
Q
G
Y
---
I
Q
V
T
D
F
G
F
A
K
R
V
--
K
---
G
R
-
T
W
-
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
S
K
G
Y
-
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
A
-----
D
Q
P
I
--
Q
I
Y
E
--
K
I
V
S
G
K
V
R
F
P
----
S
----
H
F
S
--
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
FGNLK
D
-----
G
V
N
D
I
K
N
H
K
W
---
F
-
A
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
56.75
33%
-144
- C1 -
-
3P9J
1
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
---------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
56.74
33%
-124
- C1 -
-
3M11
1
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
56.69
34%
-130
- C1 -
-
2XNG
1
AURKA_HUMAN
A:
[16-266]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
56.63
34%
-111
- C1 -
-
3UO6
3
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
56.58
34%
-111
- C1 -
-
4UMQ
1
MELK_HUMAN
A:
[37-287]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
G
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
------------------
C
G
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
Y
L
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
T
A
A
--
A
L
V
A
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
56.57
35%
-131
- C1 -
-
6GVX
1
MELK_HUMAN
B:
[21-271]
-----------------------------------------------------------------------------
I
G
T
G
--
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
---
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
K
P
---------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
G
----
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
56.54
33%
-132
- C1 -
-
2XRU
1
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--------------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
56.51
35%
-102
- C1 -
-
5IH9
1
MELK_HUMAN
A:
[16-266]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
------
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
K
-----------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
Y
L
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
56.48
35%
-109
- C1 -
-
5IHC
1
MELK_HUMAN
A:
[13-266]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
G
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
---------------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
Y
L
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
56.45
33%
-148
- C1 -
-
3DJ5
1
AURKA_MOUSE
A:
[17-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
T
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
N
G
E
---
L
K
I
A
D
F
G
W
--------------
T
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
--
E
A
-----
H
T
Y
Q
--
E
T
Y
R
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-----
L
-----
T
L
A
E
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
56.44
34%
-120
- C1 -
-
4O0S
1
AURKA_HUMAN
A:
[15-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
--
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
56.36
33%
-130
- C1 -
-
6HJK
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
C
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--------------
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
56.35
33%
-137
- C1 -
-
3LAU
1
AURKA_HUMAN
A:
[13-263]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
-----------------------
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
56.29
34%
-133
- C1 -
-
4ZTR
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
-------------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
56.09
34%
-130
- C1 -
-
2J50
1
AURKA_HUMAN
B:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
------------
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
-----
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
55.91
33%
-134
- C1 -
-
4UZH
1
AURKA_HUMAN
A:
[13-263]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
-----------------------
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
55.89
33%
-102
- C1 -
-
5ES1
1
MARK4_HUMAN
A:
[21-272]
---------------------------------------------------------------------------
R
T
I
G
K
G
N
F
A
---
K
V
K
---
L
A
---
R
H
I
L
T
G
R
E
V
A
I
K
I
I
-
D
K
T
Q
-
L
-
N
-
P
S
S
----
L
Q
K
L
F
-
R
E
V
R
I
M
K
G
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
A
G
E
V
F
D
-
Y
L
V
S
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
H
Y
C
H
Q
-
K
N
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
----
E
A
N
---
I
K
I
A
D
F
G
F
S
N
------------------
S
P
P
Y
A
A
P
E
L
F
------
Q
G
K
K
Y
-
D
G
P
E
V
D
I
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--
D
G
-----
H
N
L
K
--
E
L
R
E
--
R
V
L
R
G
K
Y
R
V
P
----
F
----
Y
M
S
--
T
D
C
E
S
I
L
R
R
F
L
V
L
N
P
A
K
R
-----
C
-----
T
L
E
Q
I
M
K
D
K
W
---
I
-
N
I
G
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
55.88
33%
-132
- C1 -
-
3DJ7
1
AURKA_MOUSE
A:
[17-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
T
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
N
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
--------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
--
E
A
-----
H
T
Y
Q
--
E
T
Y
R
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-----
L
-----
T
L
A
E
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
55.85
34%
-141
- C1 -
-
4ZTQ
2
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
---------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
55.80
34%
-130
- C1 -
-
2J50
1
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
------------
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
-----
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
55.72
34%
-109
- C1 -
-
3UOK
1
AURKA_HUMAN
B:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
589
HHSearch
55.61
31%
-57
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[7-277]
-------------------------------------------------------
M
N
--
E
------
F
E
Y
-----
L
K
L
L
G
K
G
T
F
G
---
K
V
I
---
L
V
---
K
E
K
A
T
G
R
Y
Y
A
M
K
I
L
-
K
K
E
V
-
I
V
A
-
K
D
E
----
V
A
H
T
L
-
T
E
N
R
V
L
Q
N
S
R
-
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
-
H
L
S
R
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
---
D
K
----
D
G
H
---
I
K
I
T
D
F
G
L
C
K
E
G
--
I
K
D
G
A
T
-
M
K
-
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
------
E
D
N
D
Y
-
G
R
-
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
--
Y
N
-----
Q
D
H
E
--
K
L
F
E
--
L
I
L
M
E
E
I
R
F
P
----
R
----
T
L
G
--
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
R
-----
L
GGGSE
D
A
K
E
I
M
Q
H
R
F
---
F
-
A
G
I
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
55.53
33%
-128
- C1 -
-
2XNE
1
AURKA_HUMAN
A:
[16-266]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
---------
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
N
F
G
W
S
--
V
--
H
A
P
-----------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
55.53
34%
-109
- C1 -
-
3UOK
1
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
-
R
D
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
55.51
34%
-137
- C1 -
-
3W18
1
AURKA_HUMAN
A:
[11-261]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
-----
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
------------
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
-----------------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
-----
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
55.48
33%
-121
- C1 -
-
4JBP
1
AURKA_HUMAN
A:
[14-264]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
55.46
33%
-123
- C1 -
-
3H10
1
AURKA_HUMAN
D:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
----------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
55.42
33%
-127
- C1 -
-
5AAE
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
---------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
55.39
35%
-103
- C1 -
-
5TVT
1
MELK_HUMAN
A:
[18-268]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
G
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
K
----------------
G
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
Y
L
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
55.29
34%
-130
- C1 -
-
5ONE
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
----------
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
55.29
34%
-146
- C1 -
-
3O51
1
AURKA_HUMAN
A:
[12-261]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
-----------------------
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
55.28
34%
-134
- C1 -
-
2X6E
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
-------------
T
L
D
Y
L
P
P
E
M
I
------
E
---
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
55.16
33%
-132
- C1 -
-
3QBN
1
AURKA_HUMAN
A:
[14-263]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
-------------------
T
L
S
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
55.00
35%
-103
- C1 -
-
5K00
1
MELK_HUMAN
A:
[16-266]
-----------------------------------------------------------------------------
I
G
T
G
--
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
G
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
K
P
----------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
S
Y
L
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
54.81
31%
-127
- C1 -
-
5LVP
1
PDPK1_HUMAN
C:
[37-282]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
---------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
G
--
L
I
F
A
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
54.81
35%
-108
- C1 -
-
5M5A
1
MELK_HUMAN
A:
[18-268]
-----------------------------------------------------------------------------
I
G
T
G
G
F
A
---
K
V
K
---
L
A
---
C
H
I
L
T
G
E
M
V
A
I
K
I
M
-
D
K
N
T
-
L
G
S
-
D
L
P
----
R
I
K
T
---
E
I
E
A
L
K
N
L
R
-
H
Q
H
I
C
Q
L
Y
H
V
L
E
T
A
N
K
I
F
M
V
L
E
Y
C
P
G
G
E
L
F
D
-
Y
I
I
S
Q
D
R
L
S
E
E
E
T
R
V
V
F
R
Q
I
V
S
A
V
A
Y
V
H
S
-
Q
G
Y
A
H
R
D
L
K
P
E
N
L
L
F
---
D
E
----
Y
H
K
---
L
K
L
I
D
F
G
L
C
A
------------------
S
L
A
Y
A
A
P
E
L
I
------
Q
G
K
--L
G
S
-
E
A
D
V
W
S
M
G
I
L
L
Y
V
L
M
C
G
F
L
P
F
--
D
D
-----
D
N
V
M
--
A
L
Y
K
--
K
I
M
R
G
K
Y
D
V
P
----
K
----
W
L
S
--
P
S
S
I
L
L
L
Q
Q
M
L
Q
V
D
P
K
K
R
-----
I
-----
S
M
K
N
L
L
N
H
P
W
---
I
-
M
Q
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
54.81
33%
-136
- C1 -
-
3D2I
1
AURKA_MOUSE
A:
[17-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
T
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
N
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
---------
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
--
E
A
-----
H
T
Y
Q
--
E
T
Y
R
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-----
L
-----
T
L
A
E
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
54.43
33%
-132
- C1 -
-
3H0Z
1
AURKA_HUMAN
B:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
---------
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
-----------------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
54.23
33%
-135
- C1 -
-
4UYN
1
AURKA_HUMAN
A:
[13-263]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
---
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
----------------------
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
54.04
34%
-99
- C1 -
-
3AQV
1
AAPK2_HUMAN
A:
[12-265]
-----------------------------------------------------------
H
------
Y
V
L
-----
G
D
T
L
G
V
G
T
F
G
---
K
V
K
---
I
G
---
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
-
N
R
Q
K
-
I
R
S
-
L
D
V
----
V
G
K
I
K
-
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
----
H
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
--
S
-
D
G
E
F
-
L
-------
P
N
Y
A
A
P
E
V
I
------
S
G
R
L
Y
-
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-----
E
H
V
P
--
T
L
F
K
--
K
I
R
G
G
V
F
Y
I
P
----
E
----
Y
L
N
--
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
54.02
34%
-130
- C1 -
-
4BYJ
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
-----------------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
54.00
33%
-141
- C1 -
-
3DAJ
1
AURKA_MOUSE
A:
[17-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
T
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
N
G
E
---
L
K
I
A
D
F
G
W
S
-------------------
T
L
D
Y
L
P
P
E
M
I
----------
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
--
E
A
-----
H
T
Y
Q
--
E
T
Y
R
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-----
L
-----
T
L
A
E
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
53.81
35%
-64
- C1 -
-
5FG8
3
KCC2A_DROME
A:
[22-269]
-----------------------------------------------------------------------------
L
G
K
G
A
F
S
---
I
V
K
---
R
C
---
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
--
N
T
K
-
K
L
T
-
A
R
D
----
F
Q
K
L
E
-
R
E
A
R
I
C
R
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
-
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
----
K
A
K
GAA
V
K
L
A
D
F
G
L
A
I
E
V
--
Q
G
D
H
Q
A
-
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
K
K
E
P
Y
-
G
K
-
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
-----
E
D
Q
H
--
R
L
Y
S
--
Q
I
K
A
G
A
Y
D
Y
P
----
S
PEWD
T
V
T
--
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
-----
I
-----
T
A
A
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
53.57
33%
-145
- C1 -
-
3D2K
1
AURKA_MOUSE
A:
[17-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
R
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
T
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
R
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
N
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
-------------
T
L
D
Y
L
P
P
E
M
I
------------
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
M
P
P
F
--
E
A
-----
H
T
Y
Q
--
E
T
Y
R
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
A
S
Q
R
-----
L
-----
T
L
A
E
V
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
53.47
32%
-54
- C1 -
-
5W9E
1
?
A:
[27-311]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
53.39
32%
-55
- C1 -
-
4WG3
1
?
A:
[27-303]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
53.37
32%
-55
- C1 -
-
5W91
1
?
A:
[27-411]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
53.26
34%
-93
- C1 -
-
5KZ7
1
MARK2_HUMAN
A:
[41-290]
-----------------------------------------------------------------------------
I
G
K
G
N
F
A
---
K
V
K
---
L
A
---
R
H
I
L
T
G
K
E
V
A
V
K
I
I
-
D
K
T
Q
-
L
-
N
-
S
S
S
----
L
Q
K
L
F
-
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
-
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
----
D
M
N
---
I
K
I
A
D
F
---------------------
G
S
P
P
Y
A
A
P
E
L
F
------
Q
G
K
---
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--
D
-------
N
L
K
--
E
L
R
E
--
R
V
L
R
G
K
Y
R
I
P
----
F
----
Y
M
S
--
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
---
M
-
N
V
G
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
53.20
32%
-53
- C1 -
-
3UPZ
1
?
A:
[27-410]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
555
Blastp_CBE
53.03
32%
-53
- C1 -
-
4MX9
1
?
A:
[28-305]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
554
Blastp_CBE
53.02
32%
-54
- C1 -
-
4MXA
1
?
A:
[28-305]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
Y
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
52.94
32%
-52
- C1 -
-
5W9R
1
?
A:
[27-317]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
52.89
32%
-53
- C1 -
-
4WG5
1
?
A:
[27-298]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
52.83
34%
-130
- C1 -
-
4JAI
1
AURKA_HUMAN
A:
[24-273]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
----------------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
52.81
32%
-54
- C1 -
-
4ONA
1
?
A:
[27-298]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
52.76
32%
-54
- C1 -
-
4YJN
1
?
A:
[27-303]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
52.62
32%
-55
- C1 -
-
5W80
1
?
A:
[27-305]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
----
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
52.58
32%
-52
- C1 -
-
4TZR
1
?
A:
[27-303]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
52.48
32%
-58
- C1 -
-
3UPX
1
?
A:
[27-410]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
52.46
32%
-54
- C1 -
-
3SX9
1
?
A:
[27-307]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
52.44
32%
-55
- C1 -
-
4M84
1
?
A:
[27-298]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
52.34
32%
-51
- C1 -
-
3V5P
1
?
A:
[27-410]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
52.33
32%
-56
- C1 -
-
3T3V
2
?
A:
[27-308]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
52.28
34%
-153
- C1 -
-
3W2C
1
AURKA_HUMAN
A:
[9-258]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-------------------
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
----------
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
-----------------------
T
L
D
Y
L
P
P
E
M
I
------
E
---------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
----
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
---------------------
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
52.27
32%
-53
- C1 -
-
3V51
1
?
A:
[27-304]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
52.14
35%
-62
- C1 -
-
5H9B
2
KCC2A_DROME
A:
[22-269]
-----------------------------------------------------------------------------
L
G
K
G
A
F
S
---
I
V
K
---
R
C
---
V
Q
K
S
T
G
F
E
F
A
A
K
I
I
--
N
T
K
-
K
L
T
-
A
R
D
----
F
Q
K
L
E
-
R
E
A
R
I
C
R
K
L
H
-
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
E
F
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
Q
-
N
G
V
V
H
R
D
L
K
P
E
N
L
L
L
---
A
S
----
K
A
K
GAA
V
K
L
A
D
F
G
L
A
I
E
V
--
Q
G
D
H
Q
A
-
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
K
K
E
P
Y
-
G
K
-
S
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
-----
E
D
Q
H
--
R
L
Y
S
--
Q
I
K
A
G
A
Y
D
Y
P
----
S
PEWD
T
V
T
--
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
N
K
R
-----
I
-----
T
A
A
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
52.08
31%
-25
- C1 -
-
2Y7J
1
PHKG2_HUMAN
D:
[82-363]
--------------------------------------
E
L
---
P
D
W
A
A
A
K
E
F
---
Y
Q
--
K
------
Y
D
P
-----
K
D
V
I
G
R
G
V
S
S
---
V
V
R
---
R
C
---
V
H
R
A
T
G
H
E
F
A
V
K
I
M
-
E
V
---
R
L
S
-
P
E
Q
LEEV
R
E
A
T
R
-
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
D
----
N
M
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
--
E
-
P
G
E
K
-
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
P
G
Y
-
G
K
-
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
WH
R
R
-----
Q
I
L
M
--
L
R
M
I
--
M
E
G
Q
Y
Q
F
S
S
P
----
E
----
W
D
D
RS
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
52.07
33%
-53
- C1 -
-
3MA6
1
?
A:
[33-293]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
--
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
---
I
-
Q
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
52.04
34%
-155
- C1 -
-
3W2C
1
AURKA_HUMAN
E:
[9-258]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-------------------
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
-----------
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
-----------------------
T
L
D
Y
L
P
P
E
M
I
------
E
---------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
----
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
---------------------
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
51.98
32%
-53
- C1 -
-
4WG4
1
?
A:
[27-309]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
51.57
34%
-87
- C1 -
-
5EAK
1
MARK2_HUMAN
B:
[23-272]
-----------------------------------------------------------------------------
I
G
K
G
N
F
A
---
K
V
K
---
L
A
---
R
H
I
L
T
G
K
E
V
A
V
K
I
I
-
D
K
T
Q
-
L
-
N
-
S
S
S
----
L
Q
K
L
F
-
R
E
V
R
I
M
K
V
L
N
-
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
V
M
E
Y
A
S
G
G
E
V
F
D
-
Y
L
V
A
H
G
R
M
K
E
K
E
A
R
A
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
-
K
F
I
V
H
R
D
L
K
A
E
N
L
L
L
---
D
A
----
D
M
N
---
I
K
I
A
D
F
G
------------------
F
C
G
S
P
P
Y
A
A
P
E
L
F
------
Q
G
K
K
Y
-
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
--
D
G
-----
Q
N
L
K
--
E
L
R
E
--
R
V
L
R
G
K
Y
R
I
P
----
F
----
Y
M
S
--
T
D
C
E
N
L
L
K
K
F
L
I
L
N
P
S
K
R
-----
G
-----
T
L
E
Q
I
M
K
D
R
W
---
M
-
N
V
G
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
51.45
34%
-92
- C1 -
-
6B1U
3
AAPK2_HUMAN
C:
[29-373]
------------------------------------------------------------------
Y
V
L
-----
G
D
T
L
G
V
G
T
F
G
---
K
V
K
---
I
G
---
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
-
N
R
Q
K
-
I
R
S
-
L
D
V
----
V
G
K
I
K
-
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
----
H
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
--
S
-
D
G
E
F
-
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
G
R
L
Y
-
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-----
E
H
V
P
--
T
L
F
K
--
K
I
R
G
G
V
F
Y
I
P
----
E
----
Y
L
N
--
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
---
F
-
K
Q
G
-
L
P
S
Y
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
51.45
34%
-108
- C1 -
-
6BX6
1
AAPK2_HUMAN
A:
[12-265]
-----------------------------------------------------------
H
------
Y
V
L
-----
G
D
T
L
G
V
G
T
F
G
---
K
V
K
---
I
G
---
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
-
N
R
Q
K
-
I
R
S
-
L
D
V
----
V
G
K
I
K
-
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
H
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
----
H
M
N
---
A
K
I
A
D
F
G
L
S
---------------------
N
Y
A
A
P
E
------------
Y
-
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-----
E
H
V
P
--
T
L
F
K
--
K
I
R
G
G
V
F
Y
I
P
----
E
----
Y
L
N
--
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
51.39
32%
-52
- C1 -
-
4JBV
1
?
A:
[27-303]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
51.33
38%
-92
- C1 -
-
4JXF
2
PLK4_HUMAN
A:
[12-263]
--------------------------------------------------------------------------
G
N
L
L
G
K
G
S
F
A
---
G
V
Y
---
R
A
---
E
S
I
H
T
G
L
E
V
A
I
K
M
I
-
D
K
K
A
-
M
Y
K
-
A
G
M
----
V
Q
R
V
Q
-
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
----
N
M
N
---
I
K
I
A
D
F
G
L
A
T
Q
L
--
K
M
P
H
-----------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
-----------
V
K
--
N
T
L
N
--
K
V
V
L
A
D
Y
E
M
P
----
S
----
F
L
S
--
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
-----
L
-----
S
L
S
S
V
L
D
H
P
F
---
M
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
51.22
34%
-153
- C1 -
-
3W2C
1
AURKA_HUMAN
C:
[9-258]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-------------------
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
-----------
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
-----------------------
T
L
D
Y
L
P
P
E
M
I
------
E
---------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
----
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
---------------------
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
51.13
32%
-53
- C1 -
-
3V5T
1
?
A:
[27-303]
-----------------------------------------------------------
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
50.86
31%
13
- C1 -
-
4IEB
1
?
A:
[32-322]
---------------------------------------
L
HAT
P
G
M
F
V
Q
H
S
T
AIF
S
D
--
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
----
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
M
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
PQW-
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
50.84
34%
-146
- C1 -
-
3W2C
1
AURKA_HUMAN
G:
[9-258]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-------------------
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
-----------
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
-----------------------
T
L
D
Y
L
P
P
E
M
I
------
E
---------
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
----
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
---------------------
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
50.77
32%
-65
- C1 -
-
2BIY
6
PDPK1_HUMAN
A:
[35-280]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
SP
E
S
K
Q
A
R
-
A
N
-
A
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
50.18
34%
-87
- C1 -
-
5KQ5
2
?
A:
[18-399]
------------------------------------------------------------------
Y
I
L
-----
G
D
T
L
G
V
G
T
F
G
---
K
V
K
---
V
G
---
K
H
E
L
T
G
H
K
V
A
V
K
I
L
-
N
R
Q
K
-
I
R
S
-
L
D
V
----
V
G
K
I
R
-
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
----
H
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
--
S
-
D
G
E
F
-
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
G
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-----
D
H
V
P
--
T
L
F
K
--
K
I
C
D
G
I
F
Y
T
P
----
Q
----
Y
L
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
50.18
38%
-98
- C1 -
-
3COK
1
PLK4_HUMAN
B:
[16-267]
--------------------------------------------------------------------------
G
N
L
L
G
K
G
S
F
A
---
G
V
Y
---
R
A
---
E
S
I
H
T
G
L
E
V
A
I
K
M
I
-
D
K
K
A
-
M
Y
K
-
A
G
M
----
V
Q
R
V
Q
-
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
----
N
M
N
---
I
K
I
A
D
F
G
L
A
T
Q
L
--
K
------------------------------------
L
-
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
---------------
N
T
L
N
--
K
V
V
L
A
D
Y
E
M
P
----
S
----
F
L
S
--
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
-----
L
-----
S
L
S
S
V
L
D
H
P
F
---
M
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
50.00
32%
-87
- C1 -
-
3ION
1
PDPK1_HUMAN
A:
[38-283]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
S-------------
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
49.76
38%
-93
- C1 -
-
3COK
1
PLK4_HUMAN
A:
[16-267]
--------------------------------------------------------------------------
G
N
L
L
G
K
G
S
F
A
---
G
V
Y
---
R
A
---
E
S
I
H
T
G
L
E
V
A
I
K
M
I
-
D
K
K
A
-
M
Y
K
-
A
G
M
----
V
Q
R
V
Q
-
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
----
N
M
N
---
I
K
I
A
D
F
G
L
A
T
Q
L
--
K
--------------------------------------
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
--
D
T
-----
D
T
V
---------
K
V
V
L
A
D
Y
E
M
P
----
S
----
F
L
S
--
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
-----
L
-----
S
L
S
S
V
L
D
H
P
F
---
M
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
49.48
34%
-86
- C1 -
-
6E4U
2
AAPK1_RAT
A:
[18-397]
------------------------------------------------------------------
Y
I
L
-----
G
D
T
L
G
V
G
T
F
G
---
K
V
K
---
V
G
---
K
H
E
L
T
G
H
K
V
A
V
K
I
L
-
N
R
Q
K
-
I
R
S
-
L
D
V
----
V
G
K
I
R
-
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
----
H
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
--
S
-
D
G
E
F
-
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
G
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-----
D
H
V
P
--
T
L
F
K
--
K
I
C
D
G
I
F
Y
T
P
----
Q
----
Y
L
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
49.29
34%
-86
- C1 -
-
4QFS
2
A:
[18-401]
------------------------------------------------------------------
Y
I
L
-----
G
D
T
L
G
V
G
T
F
G
---
K
V
K
---
V
G
---
K
H
E
L
T
G
H
K
V
A
V
K
I
L
-
N
R
Q
K
-
I
R
S
-
L
D
V
----
V
G
K
I
R
-
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
----
H
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
--
S
-
D
G
E
F
-
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
G
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-----
D
H
V
P
--
T
L
F
K
--
K
I
C
D
G
I
F
Y
T
P
----
Q
----
Y
L
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
49.00
31%
-1
- C1 -
-
2Y7J
1
PHKG2_HUMAN
A:
[82-363]
--------------------------------------
E
L
---
P
D
W
A
A
A
K
E
F
---
Y
Q
--
K
------
Y
D
P
-----
K
D
V
I
G
R
G
V
S
S
---
V
V
R
---
R
C
---
V
H
R
A
T
G
H
E
F
A
V
K
I
M
-
E
V
T
A
E
R
L
S
-
P
E
Q
LEEV
R
E
A
T
R
-
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
D
----
N
M
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
--
E
-
P
G
E
K
-
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
P
G
Y
-
G
K
-
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
WH
R
R
-----
Q
I
L
M
--
L
R
M
I
--
M
E
G
Q
Y
Q
F
S
S
P
----
E
----
W
D
D
RS
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
48.99
34%
-86
- C1 -
-
4QFR
2
?
A:
[18-401]
------------------------------------------------------------------
Y
I
L
-----
G
D
T
L
G
V
G
T
F
G
---
K
V
K
---
V
G
---
K
H
E
L
T
G
H
K
V
A
V
K
I
L
-
N
R
Q
K
-
I
R
S
-
L
D
V
----
V
G
K
I
R
-
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
----
H
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
--
S
-
D
G
E
F
-
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
G
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-----
D
H
V
P
--
T
L
F
K
--
K
I
C
D
G
I
F
Y
T
P
----
Q
----
Y
L
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
48.97
31%
1
- C1 -
-
5T6I
1
?
A:
[62-441]
---------------------------------------------------
T
AIF
S
D
--
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
---
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
-----
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
48.89
34%
-90
- C1 -
-
4CFH
1
AAPK1_RAT
A:
[35-346]
------------------------------------------------------------------
Y
I
L
-----
G
D
T
L
G
V
G
T
F
G
---
K
V
K
---
V
G
---
K
H
E
L
T
G
H
K
V
A
V
K
I
L
-
N
R
Q
K
-
I
R
S
-
L
D
V
----
V
G
K
I
R
-
R
E
I
Q
N
L
K
L
F
R
-
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
-
Y
I
C
K
N
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
-
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
---
D
A
----
H
M
N
---
A
K
I
A
D
F
G
L
S
N
M
M
--
S
-
D
G
E
F
-
L
R
-
S
-
C
G
S
P
N
Y
A
A
P
E
V
I
------
S
G
R
L
Y
-
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-----
D
H
V
P
--
T
L
F
K
--
K
I
C
D
G
I
F
Y
T
P
----
Q
----
Y
L
N
--
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
-----
A
-----
T
I
K
D
I
R
E
H
E
W
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
86
Blastp_CBE
48.67
38%
-104
- C1 -
-
4YUR
1
PLK4_HUMAN
A:
[18-269]
--------------------------------------------------------------------------
G
N
L
L
G
K
G
S
F
A
---
G
V
Y
---
R
A
---
E
S
I
H
T
G
L
E
V
A
I
K
M
I
-
D
K
K
A
-
M
Y
K
-
A
G
M
----
V
Q
R
V
Q
-
N
E
V
K
I
H
C
Q
L
K
-
H
P
S
I
L
E
L
Y
N
Y
F
E
D
S
N
Y
V
Y
L
V
L
E
M
C
H
N
G
E
M
N
R
Y
L
K
N
R
V
K
P
F
S
E
N
E
A
R
H
F
M
H
Q
I
I
T
G
M
L
Y
L
H
S
-
H
G
I
L
H
R
D
L
T
L
S
N
L
L
L
---
T
R
----
N
M
N
---
I
K
I
A
D
F
--------------------------------------------
G
L
-
E
S
D
V
W
S
L
G
C
M
F
Y
T
L
L
I
G
R
P
P
F
----------
T
V
K
--
N
T
L
N
--
K
V
V
L
A
D
Y
E
M
P
----
S
----
F
L
S
--
I
E
A
K
D
L
I
H
Q
L
L
R
R
N
P
A
D
R
-----
L
-----
S
L
S
S
V
L
D
H
P
F
---
M
-
S
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
48.66
31%
0
- C1 -
-
5JMS
2
?
A:
[62-454]
---------------------------------------------------
T
AIF
S
D
--
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
48.62
31%
0
- C1 -
-
5T6K
1
?
A:
[62-491]
---------------------------------------------------
T
AIF
S
D
--
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
--
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
48.59
31%
-1
- C1 -
-
4IHP
1
?
A:
[44-474]
---------------------------------------------------
T
AIF
S
D
--
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
48.54
31%
-3
- C1 -
-
4IFG
1
?
A:
[44-333]
---------------------------------------------------
T
AIF
S
D
--
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
48.44
31%
3
- C1 -
-
5JN2
1
?
A:
[61-452]
--------------------------------------------------
S
T
AIF
S
D
--
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
48.14
32%
-70
- C1 -
-
3NAX
1
PDPK1_HUMAN
A:
[34-279]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
SP
E
S
K
Q
A
R
---------
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
48.02
31%
-2
- C1 -
-
3KU2
1
?
A:
[44-328]
---------------------------------------------------
T
AIF
S
D
--
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
48.00
32%
-0
- C1 -
-
4NW5
1
KS6A3_HUMAN
A:
[36-300]
---------------------------------------------------------------------------
K
V
L
G
Q
G
S
F
G
---
K
V
F
LVK
K
I
---
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
-
K
K
A
T
-
L
-
K
-
V
R
D
----
R
V
R
T
K
-
M
E
R
D
I
L
V
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
-
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
----
E
G
H
---
I
K
L
T
D
F
G
L
-
S
K
E
--
S
I
D
H
E
K
-
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
------
N
R
R
G
H
-
T
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
--
Q
G
-----
K
D
R
K
--
E
T
M
T
--
M
I
L
K
A
K
L
G
M
P
----
Q
----
F
L
S
--
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
LGAGP
D
-----
G
V
E
E
I
K
R
H
S
F
---
F
-
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
48.00
32%
1
- C1 -
-
4NW6
1
KS6A3_HUMAN
A:
[36-300]
---------------------------------------------------------------------------
K
V
L
G
Q
G
S
F
G
---
K
V
F
LVK
K
I
---
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
-
K
K
A
T
-
L
-
K
-
V
R
D
----
R
V
R
T
K
-
M
E
R
D
I
L
V
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
-
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
----
E
G
H
---
I
K
L
T
D
F
G
L
-
S
K
E
--
S
I
D
H
E
K
-
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
------
N
R
R
G
H
-
T
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
--
Q
G
-----
K
D
R
K
--
E
T
M
T
--
M
I
L
K
A
K
L
G
M
P
----
Q
----
F
L
S
--
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
LGAGP
D
-----
G
V
E
E
I
K
R
H
S
F
---
F
-
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
47.92
31%
-3
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[82-363]
--------------------------------------
E
L
---
P
D
W
A
A
A
K
E
F
---
Y
Q
--
K
------
Y
D
P
-----
K
D
V
I
G
R
G
V
S
S
---
V
V
R
---
R
C
---
V
H
R
A
T
G
H
E
F
A
V
K
I
M
-
E
V
T
A
E
R
L
S
-
P
E
Q
LEEV
R
E
A
T
R
-
R
E
T
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
-
Y
L
T
E
K
V
A
L
S
E
K
E
T
R
S
I
M
R
S
L
L
E
A
V
S
F
L
H
A
-
N
N
I
V
H
R
D
L
K
P
E
N
I
L
L
---
D
D
----
N
M
Q
---
I
R
L
S
D
F
G
F
S
C
H
L
--
E
-
P
G
E
K
-
L
R
-
E
L
C
G
T
P
G
Y
L
A
P
E
I
L
KCSMDE
T
H
P
G
Y
-
G
K
-
E
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
WH
R
R
-----
Q
I
L
M
--
L
R
M
I
--
M
E
G
Q
Y
Q
F
S
S
P
----
E
----
W
D
D
RS
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
E
A
R
-----
L
-----
T
A
E
Q
A
L
Q
H
P
F
---
F
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
47.72
31%
-4
- C1 -
-
5DVR
1
?
A:
[62-449]
---------------------------------------------------
T
AIF
S
D
--
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
---
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
--
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
47.60
34%
-81
- C1 -
-
6T6F
1
?
A:
[22-280]
-----------------------------------------------------------------------------
L
G
T
G
A
F
S
---
E
V
V
---
L
A
---
E
E
K
A
T
G
K
L
F
A
V
K
C
I
-
P
K
K
A
-
L
---
K
G
K
----
E
S
S
I
E
-
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
-
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSQ
D
E
----
E
S
K
---
I
M
I
S
D
F
G
L
-
S
-------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
D
-----
E
N
D
S
--
K
L
F
E
--
Q
I
L
K
A
E
Y
E
F
D
----
S
PYWD
D
I
S
--
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
-----
Y
-----
T
C
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
47.45
34%
-90
- C1 -
-
2JC6
1
KCC1D_HUMAN
C:
[30-273]
-----------------------------------------------------------------------------
L
G
T
G
A
F
S
---
E
V
V
---
L
A
---
E
E
K
A
T
G
K
L
F
A
V
K
C
I
-
P
K
K
A
--------------
S
I
E
-
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
-
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSQ
D
E
----
E
S
K
---
I
M
I
S
-------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
D
-----
E
N
D
S
--
K
L
F
E
--
Q
I
L
K
A
E
Y
E
F
D
----
S
PYWD
D
I
S
--
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
-----
Y
-----
T
C
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
47.38
32%
-70
- C1 -
-
3PWY
1
PDPK1_HUMAN
A:
[37-282]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
C
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
SP----------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
S
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
47.35
34%
-79
- C1 -
-
6T6F
1
?
B:
[22-280]
-----------------------------------------------------------------------------
L
G
T
G
A
F
S
---
E
V
V
---
L
A
---
E
E
K
A
T
G
K
L
F
A
V
K
C
I
-
P
K
K
A
-
L
---
K
G
K
----
E
S
S
I
E
-
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
-
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSQ
D
E
----
E
S
K
---
I
M
I
S
D
F
G
----------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
D
-----
E
N
D
S
--
K
L
F
E
--
Q
I
L
K
A
E
Y
E
F
D
----
S
PYWD
D
I
S
--
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
-----
Y
-----
T
C
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
47.34
34%
-88
- C1 -
-
3KN5
1
KS6A5_HUMAN
A:
[19-277]
-----------------------------------------------------------------------------
L
G
E
G
S
F
S
---
I
C
R
---
K
C
---
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
-
S
K
R
M
-
E
A
N
-
T
-
Q
----
K
E
I
T
A
-
L
K
L
C
----
E
G
-
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
-
R
I
K
K
K
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
-
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
TD--------
L
E
---
I
K
I
I
D
F
G
F
A
R
L
K
--
P
P
------------------------------
N
G
Y
-
D
E
-
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
--
Q
-------
C
T
S
AV
E
I
M
K
--
K
I
K
K
G
D
F
S
F
E
GEAW
K
----
N
V
S
--
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
-----
L
-----
K
M
S
G
L
R
Y
N
E
W
---
L
-
Q
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
47.27
31%
-81
- C1 -
-
5LVP
1
PDPK1_HUMAN
D:
[37-282]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
G
--
L
I
F
A
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
47.21
34%
-80
- C1 -
-
3KN5
1
B:
[19-277]
-----------------------------------------------------------------------------
L
G
E
G
S
F
S
---
I
C
R
---
K
C
---
V
H
K
K
S
N
Q
A
F
A
V
K
I
I
-
S
K
R
M
-
E
A
N
-
T
-
Q
----
K
E
I
T
A
-
L
K
L
C
----
E
G
-
H
P
N
I
V
K
L
H
E
V
F
H
D
Q
L
H
T
F
L
V
M
E
L
L
N
G
G
E
L
F
E
-
R
I
K
K
K
K
H
F
S
E
T
E
A
S
Y
I
M
R
K
L
V
S
A
V
S
H
M
H
D
-
V
G
V
V
H
R
D
L
K
P
E
N
L
L
F
TD--------
L
E
---
I
K
I
I
D
F
G
F
A
R
L
K
--
P
P
------------------------------
N
G
Y
-
D
E
-
S
C
D
L
W
S
L
G
V
I
L
Y
T
M
L
S
G
Q
V
P
F
--
Q
S
HDRSL
T
C
T
S
AV
E
I
M
K
--
K
I
K
K
G
D
F
S
F
E
GEAW
K
----
N
V
S
--
Q
E
A
K
D
L
I
Q
G
L
L
T
V
D
P
N
K
R
-----
L
-----
K
M
S
G
L
R
Y
N
E
W
---
L
-
Q
D
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
47.12
33%
-75
- C1 -
-
5ORT
2
AURKA_HUMAN
A:
[10-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
47.09
33%
-77
- C1 -
-
5DNR
1
AURKA_HUMAN
A:
[17-266]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
46.98
34%
-94
- C1 -
-
2JC6
1
KCC1D_HUMAN
A:
[30-273]
-----------------------------------------------------------------------------
L
G
T
G
A
F
S
---
E
V
V
---
L
A
---
E
E
K
A
T
G
K
L
F
A
V
K
C
I
-
P
K
K
A
-------------
S
S
I
E
-
N
E
I
A
V
L
R
K
I
K
-
H
E
N
I
V
A
L
E
D
I
Y
E
S
P
N
H
L
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
V
E
K
G
F
Y
T
E
K
D
A
S
T
L
I
R
Q
V
L
D
A
V
Y
Y
L
H
R
-
M
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
YSQ
D
E
----
E
S
K
---
I
M
I
S
-------------------------
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
-
A
V
D
C
W
S
I
G
V
I
A
Y
I
L
L
C
G
Y
P
P
F
--
Y
D
-----
E
N
D
S
--
K
L
F
E
--
Q
I
L
K
A
E
Y
E
F
D
----
S
PYWD
D
I
S
--
D
S
A
K
D
F
I
R
N
L
M
E
K
D
P
N
K
R
-----
Y
-----
T
C
E
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
46.97
31%
32
- C1 -
-
3HX4
3
?
A:
[31-322]
-------------------------------------
D
H
L
HAT
P
G
M
F
V
Q
H
S
T
AIF
S
D
--
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
---------
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
ESK
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
46.80
31%
9
- C1 -
-
4IH8
1
?
A:
[45-435]
----------------------------------------------------AIF
S
D
--
R
------
Y
K
G
-----
Q
R
V
L
G
K
G
S
F
G
---
E
V
I
---
L
C
---
K
D
K
I
T
G
Q
E
C
A
V
K
V
I
-
S
K
R
Q
-
V
K
Q
-
K
T
D
----
K
E
S
L
L
-
R
E
V
Q
L
L
K
Q
L
D
-
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
-
E
I
I
S
R
K
R
F
S
E
V
D
A
A
R
I
I
R
Q
V
L
S
G
I
T
Y
M
H
K
-
N
K
I
V
H
R
D
L
K
P
E
N
L
L
L
E--
S
K
----
D
A
N
---
I
R
I
I
D
F
G
L
S
T
H
F
--
E
A
-
S
K
K
-
M
K
-
D
K
I
G
T
A
Y
Y
I
A
P
E
V
L
------
H
G
T
-
Y
-
D
E
-
K
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
--
N
G
-----
A
N
E
Y
--
D
I
L
K
--
K
V
E
K
G
K
Y
T
F
E
LPQW
K
----
K
V
S
--
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
S
M
R
-----
I
-----
S
A
R
D
A
L
D
H
E
W
IQT
Y
-
T
K
E
Q
I
S
V
D
V
P
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
46.75
33%
-79
- C1 -
-
5OSE
2
AURKA_HUMAN
A:
[10-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
46.73
32%
-0
- C1 -
-
5D9L
2
KS6A3_HUMAN
A:
[36-293]
---------------------------------------------------------------------------
K
V
L
G
Q
G
S
F
G
---
K
V
F
LVK
K
I
---
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
-
K
K
A
T
-
L
-
K
-
V
R
D
----
R
V
R
T
K
-
M
E
R
D
I
L
V
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
-
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
----
E
G
H
---
I
K
L
T
D
F
G
L
-
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
------
N
R
R
G
H
-
T
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
--
Q
G
-----
K
D
R
K
--
E
T
M
T
--
M
I
L
K
A
K
L
G
M
P
----
Q
----
F
L
S
--
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
LGAGP
D
-----
G
V
E
E
I
K
R
H
S
F
---
F
-
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
46.62
33%
-81
- C1 -
-
5G1X
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
46.61
33%
-75
- C1 -
-
5OS3
2
AURKA_HUMAN
A:
[10-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
46.49
33%
-87
- C1 -
-
3E5A
1
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
46.46
31%
-85
- C1 -
-
5LVP
1
PDPK1_HUMAN
A:
[37-282]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
G
--
L
I
F
A
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
46.30
33%
1
- C1 -
-
3BHY
1
DAPK3_HUMAN
A:
[7-264]
------------------------------------------------------------------
Y
E
M
-----
G
E
E
L
G
S
G
Q
F
A
---
I
V
R
---
K
C
---
R
Q
K
G
T
G
K
E
Y
A
A
K
F
I
-
K
K
R
R
-
L
S
S
-
S
R
R
GVS-
R
E
E
I
E
-
R
E
V
N
I
L
R
E
I
R
-
H
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
-
F
L
A
E
K
E
S
L
T
E
D
E
A
T
Q
F
L
K
Q
I
L
D
G
V
H
Y
L
H
S
-
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
---
L
D
KNVP
N
P
R
---
I
K
L
I
D
F
G
I
A
H
K
I
--
E
-----------
F
G
T
P
E
F
V
A
P
E
I
V
------
N
Y
E
P
L
-
G
L
-
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
--
L
G
-----
E
T
K
Q
--
E
T
L
T
--
N
I
S
A
V
N
Y
D
F
D
----
E
EYFS
N
T
S
--
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
K
R
R
-----
M
-----
T
I
A
Q
S
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
46.28
33%
-76
- C1 -
-
5ORW
2
AURKA_HUMAN
A:
[10-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
556
Blastp_CBE
46.25
31%
-80
- C1 -
-
5HO8
1
PDPK1_HUMAN
A:
[35-280]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
---------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
46.15
33%
-77
- C1 -
-
5OSD
2
AURKA_HUMAN
A:
[12-261]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
46.14
36%
-2
- C1 -
-
2VN9
1
KCC2D_HUMAN
B:
[12-259]
-----------------------------------------------------------------------------
L
G
K
G
A
F
S
VVR
R
C
M
---
K
I
---
P
---
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
A
R
-
D
H
Q
------
K
L
E
-
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
ASK
S
K
----
G
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
--
Q
G
D
Q
Q
A
-
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
-
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
-----
E
D
Q
H
--
R
L
Y
Q
--
Q
I
K
A
G
A
Y
D
F
P
----
S
PEWD
T
V
T
--
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
-----
T
A
S
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
46.13
33%
-81
- C1 -
-
5L8K
9
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
46.04
33%
-71
- C1 -
-
4CEG
3
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
46.01
31%
-52
- C1 -
-
4DC2
1
KPCI_MOUSE
A:
[58-304]
---------------------------------------------------------------------------
R
V
I
G
R
G
S
Y
A
---
K
V
L
---
L
V
---
R
L
K
K
T
D
R
I
Y
A
M
R
V
V
-
K
K
E
L
-
V
N
---------
I
D
W
V
Q
-
T
E
K
H
V
F
E
Q
A
S
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
-
H
M
Q
R
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
I
I
Y
R
D
L
K
L
D
N
V
L
L
---
D
S
----
E
G
H
---
I
K
L
T
D
Y
G
M
C
K
E
G
--
L
R
P
G
D
T
-
T
S
-
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
------
R
G
E
D
Y
-
G
F
-
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
S
P
F
--
D
I
-----
V
G
S
-NT
E
D
Y
L
FQ
V
I
L
E
K
Q
I
R
I
P
----
R
----
S
L
S
--
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
45.95
33%
-74
- C1 -
-
5OS4
2
AURKA_HUMAN
A:
[10-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
45.93
33%
-66
- C1 -
-
2W1C
1
AURKA_HUMAN
A:
[16-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
-
S
R
-
R
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
45.91
33%
-78
- C1 -
-
5ORY
2
AURKA_HUMAN
A:
[10-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
45.86
36%
-6
- C1 -
-
6BAB
2
KCC2D_MOUSE
B:
[17-268]
-----------------------------------------------------------------------------
L
G
K
G
A
F
S
VVR
R
C
M
---
K
I
---
P
---
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
A
R
-
D
H
Q
------
K
L
E
-
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
ASK
S
K
----
G
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
--
Q
G
D
Q
Q
A
-
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
-
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
-----
E
D
Q
H
--
R
L
Y
Q
--
Q
I
K
A
G
A
Y
D
F
P
----
S
PEWD
T
V
T
--
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
-----
T
A
S
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
45.76
33%
-73
- C1 -
-
5ORV
2
AURKA_HUMAN
A:
[10-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
45.74
33%
-74
- C1 -
-
6R4B
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
45.61
33%
-79
- C1 -
-
5L8L
4
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
45.57
33%
-77
- C1 -
-
5ORZ
2
AURKA_HUMAN
A:
[10-259]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
A
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
45.54
33%
-73
- C1 -
-
3HA6
1
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
-
S
R
-
R
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
45.52
36%
-0
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[12-263]
-----------------------------------------------------------------------------
L
G
K
G
A
F
S
VVR
R
C
M
---
K
I
---
P
---
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
A
R
-
D
H
Q
------
K
L
E
-
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
ASK
S
K
----
G
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
--
Q
G
D
Q
Q
A
-
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
-
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
-----
E
D
Q
H
--
R
L
Y
Q
--
Q
I
K
A
G
A
Y
D
F
P
----
S
PEWD
T
V
T
--
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
-----
T
A
S
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
45.48
31%
-75
- C1 -
-
5LVP
1
PDPK1_HUMAN
B:
[37-282]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
---------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
G
--
L
I
F
A
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
45.45
36%
-5
- C1 -
-
5VLO
2
KCC2D_HUMAN
A:
[18-268]
-----------------------------------------------------------------------------
L
G
K
G
A
F
S
VVR
R
C
M
---
K
I
---
P
---
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
A
R
-
D
H
Q
------
K
L
E
-
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
ASK
S
K
----
G
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
--
Q
G
D
Q
Q
A
-
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
-
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
-----
E
D
Q
H
--
R
L
Y
Q
--
Q
I
K
A
G
A
Y
D
F
P
----
S
PEWD
T
V
T
--
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
-----
T
A
S
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
45.32
33%
-66
- C1 -
-
2JAM
3
KCC1G_HUMAN
A:
[8-261]
-------------------------------------------------------
R
K
--
T
------
F
I
F
-----
M
E
V
L
G
S
G
A
F
S
---
E
V
F
---
L
V
---
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
-
K
K
S
--------
S
----
L
E
N
----
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
LTP
E
E
----
N
S
K
---
I
M
I
T
D
F
G
L
-
S
K
M
--
E
Q
N
G
-
I
-
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
-
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
--
Y
E
-----
E
T
E
S
--
K
L
F
E
--
K
I
K
E
G
Y
Y
E
F
E
----
S
PFWD
D
I
S
--
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
-----
Y
-----
T
C
E
K
A
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
45.20
32%
3
- C1 -
-
5D9K
2
KS6A3_HUMAN
B:
[36-300]
---------------------------------------------------------------------------
K
V
L
G
Q
G
S
F
G
---
K
V
F
LVK
K
I
---
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
-
K
K
A
T
-
L
-
K
-
V
R
D
----
R
V
R
T
K
-
M
E
R
D
I
L
V
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
-
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
----
E
G
H
---
I
K
L
T
D
F
G
L
-
S
K
E
--------------
C
G
T
V
E
Y
M
A
P
E
V
V
------
N
R
R
G
H
-
T
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
--
Q
G
-----
K
D
R
K
--
E
T
M
T
--
M
I
L
K
A
K
L
G
M
P
----
Q
----
F
L
S
--
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
LGAGP
D
-----
G
V
E
E
I
K
R
H
S
F
---
F
-
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
45.08
31%
-42
- C1 -
-
5N23
1
KAPCA_HUMAN
A:
[43-343]
-----------------------------------------------------------
Q
------
F
E
R
-----
I
R
T
L
G
T
G
S
F
G
---
R
V
M
---
L
V
---
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
-
D
K
Q
K
-
V
V
K
-
L
K
Q
----
I
E
H
T
L
-
N
E
K
R
I
Q
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
--
H
L
R
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
----
Q
G
Y
---
I
K
V
A
D
F
G
F
A
K
R
V
--
K
---
G
R
-
T
P
-
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
S
K
G
Y
-
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
A
-----
D
Q
P
I
--
Q
I
Y
E
--
K
I
V
S
G
K
V
R
F
P
----
S
----
H
F
S
--
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
---
F
A
T
T
D
W
I
A
I
Y
Q
R
K
-
V
E
A
P
F
I
P
K
F
K
----
N
F
D
D
Y
E
E
E
E
I
R
V
I
N
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
45.04
31%
-63
- C1 -
-
3RCJ
1
PDPK1_HUMAN
A:
[37-282]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
P
E
S
K
Q
A
R
A
-
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
G
--
L
I
F
A
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
557
Blastp_CBE
44.99
31%
-86
- C1 -
-
5HO7
1
PDPK1_HUMAN
A:
[35-280]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
P
--------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
44.99
32%
-68
- C1 -
-
1OL7
1
AURKA_HUMAN
A:
[15-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
-
S
R
-
R
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
44.90
33%
-64
- C1 -
-
2JAM
3
KCC1G_HUMAN
B:
[8-261]
-------------------------------------------------------
R
K
--
T
------
F
I
F
-----
M
E
V
L
G
S
G
A
F
S
---
E
V
F
---
L
V
---
K
Q
R
L
T
G
K
L
F
A
L
K
C
I
-
K
K
S
--------
S
----
L
E
N
----
E
I
A
V
L
K
K
I
K
-
H
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
-
R
I
L
E
R
G
V
Y
T
E
K
D
A
S
L
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
E
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
Y
LTP
E
E
----
N
S
K
---
I
M
I
T
D
F
G
L
-
S
K
M
--
E
Q
N
G
-
I
-
M
S
-
T
A
C
G
T
P
G
Y
V
A
P
E
V
L
------
A
Q
K
P
Y
-
S
K
-
A
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
--
Y
E
-----
E
T
E
S
--
K
L
F
E
--
K
I
K
E
G
Y
Y
E
F
E
----
S
PFWD
D
I
S
--
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
N
E
R
-----
Y
-----
T
C
E
K
A
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
44.82
36%
-3
- C1 -
-
6BAB
2
KCC2D_MOUSE
A:
[21-268]
-----------------------------------------------------------------------------
L
G
K
G
A
F
S
VVR
R
C
M
---
K
I
---
P
---
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
A
R
-
D
H
Q
------
K
L
E
-
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
ASK
S
K
----
G
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
--
Q
G
D
Q
Q
A
-
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
-
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
-----
E
D
Q
H
--
R
L
Y
Q
--
Q
I
K
A
G
A
Y
D
F
P
----
S
PEWD
T
V
T
--
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
-----
T
A
S
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
44.80
33%
-65
- C1 -
-
6I2U
4
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
-
S
R
-
R
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
44.71
36%
-5
- C1 -
-
6BAB
1
KCC2D_MOUSE
D:
[21-268]
-----------------------------------------------------------------------------
L
G
K
G
A
F
S
VVR
R
C
M
---
K
I
---
P
---
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
A
R
-
D
H
Q
------
K
L
E
-
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
ASK
S
K
----
G
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
--
Q
G
D
Q
Q
A
-
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
-
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
-----
E
D
Q
H
--
R
L
Y
Q
--
Q
I
K
A
G
A
Y
D
F
P
----
S
PEWD
T
V
T
--
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
-----
T
A
S
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
44.69
32%
-68
- C1 -
-
1OL5
1
AURKA_HUMAN
A:
[15-265]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
-
S
R
-
R
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
44.65
31%
-65
- C1 -
-
4RQV
5
PDPK1_HUMAN
A:
[37-282]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
P
E
S
K
Q
A
R
A
-
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
G
--
L
I
F
A
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
44.61
33%
-61
- C1 -
-
4BN1
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
M
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
-
S
R
-
R
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
Blastp_CBE
44.51
31%
-68
- C1 -
-
3HRC
1
PDPK1_HUMAN
A:
[37-282]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
P
----A
R
A
-
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
G
--
L
I
F
A
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
44.43
36%
-0
- C1 -
-
6BAB
2
KCC2D_MOUSE
C:
[21-268]
-----------------------------------------------------------------------------
L
G
K
G
A
F
S
VVR
R
C
M
---
K
----------
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
A
R
-
D
H
Q
------
K
L
E
-
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
ASK
S
K
----
G
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
--
Q
G
D
Q
Q
A
-
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
-
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
-----
E
D
Q
H
--
R
L
Y
Q
--
Q
I
K
A
G
A
Y
D
F
P
----
S
PEWD
T
V
T
--
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
-----
T
A
S
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
44.34
36%
-4
- C1 -
-
5VLO
2
KCC2D_HUMAN
B:
[21-268]
-----------------------------------------------------------------------------
L
G
K
G
A
F
S
VVR
R
C
M
---
K
I
---
P
---
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
A
R
-
D
H
Q
------
K
L
E
-
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
ASK
S
K
----
G
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
--
Q
G
D
Q
Q
A
-
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
-
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
-----
E
D
Q
H
--
R
L
Y
Q
--
Q
I
K
A
G
A
Y
D
F
P
----
S
PEWD
T
V
T
--
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
-----
T
A
S
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
Blastp_CBE
44.33
31%
-66
- C1 -
-
4A06
3
PDPK1_HUMAN
A:
[37-282]
--------------------------------------------------------------------------
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
P
E
S
K
Q
A
R
A
-
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
G
--
L
I
F
A
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
44.25
33%
-79
- C1 -
-
5DT3
1
AURKA_HUMAN
A:
[13-262]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
V
-----
H
A
P
S
S
-
R
R
-
T
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
44.25
32%
-1
- C1 -
-
2BMC
1
AURKA_HUMAN
D:
[30-289]
------------------------------------------------------------QWALED
F
E
I
-----
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
----------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
44.07
33%
-1
- C1 -
-
4L42
1
KS6B1_HUMAN
A:
[24-299]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
-
I
V
R
N
A
K
D
----
T
A
H
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--
I
H
D
G
T
V
-
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
44.03
34%
-75
- C1 -
-
2DWB
1
AURKA_HUMAN
A:
[18-267]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
----
T
L
C
G
T
L
D
Y
L
P
P
E
I
E
------
G
R
--
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
------
L
R
E
V
L
E
H
P
W
---
I
-
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
44.01
36%
-4
- C1 -
-
6AYW
2
KCC2D_HUMAN
A:
[21-268]
-----------------------------------------------------------------------------
L
G
K
G
A
F
S
VVR
R
C
M
---
K
I
---
P
---
T
G
Q
E
Y
A
A
K
I
I
N
T
K
K
L
-
S
A
R
-
D
H
Q
------
K
L
E
-
R
E
A
R
I
C
R
L
L
K
-
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
-
D
I
V
A
R
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
S
V
N
H
C
H
L
-
N
G
I
V
H
R
D
L
K
P
E
N
L
L
L
ASK
S
K
----
G
A
A
---
V
K
L
A
D
F
G
L
A
I
E
V
--
Q
G
D
Q
Q
A
-
W
F
-
G
F
A
G
T
P
G
Y
L
S
P
E
V
L
------
R
K
D
P
Y
-
G
K
-
P
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
--
W
D
-----
E
D
Q
H
--
R
L
Y
Q
--
Q
I
K
A
G
A
Y
D
F
P
----
S
PEWD
T
V
T
--
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
A
K
R
-----
I
-----
T
A
S
E
A
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
43.66
32%
-0
- C1 -
-
2BMC
1
AURKA_HUMAN
E:
[30-289]
------------------------------------------------------------QWALED
F
E
I
-----
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
----------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
43.23
32%
-12
- C1 -
-
4GUE
1
KS6A3_MOUSE
A:
[31-288]
---------------------------------------------------------------------------
K
V
L
G
Q
G
S
F
G
---
K
V
F
LVK
K
I
---
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
-
K
K
A
T
-
L
-
K
-
V
R
D
----
R
V
---------
L
V
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
-
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
----
E
G
H
---
I
K
L
T
D
F
G
L
-
S
K
-------
E
K
-
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
------
N
R
R
G
H
-
T
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
--
Q
G
-----
K
D
R
K
--
E
T
M
T
--
M
I
L
K
A
K
L
G
M
P
----
Q
----
F
L
S
--
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
LGAGP
D
-----
G
V
E
E
I
K
R
H
S
F
---
F
-
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
43.13
32%
-6
- C1 -
-
3G51
1
KS6A3_MOUSE
A:
[30-287]
---------------------------------------------------------------------------
K
V
L
G
Q
G
S
F
G
---
K
V
F
LVK
K
I
---
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
-
K
K
A
T
-
L
-
K
-
V
R
D
--------------
I
L
V
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
-
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
----
E
G
H
---
I
K
L
T
D
F
G
L
-
S
K
E
--
S
I
------------
T
V
E
Y
M
A
P
E
V
V
------
N
R
R
G
H
-
T
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
--
Q
G
-----
K
D
R
K
--
E
T
M
T
--
M
I
L
K
A
K
L
G
M
P
----
Q
----
F
L
S
--
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
LGAGP
D
-----
G
V
E
E
I
K
R
H
S
F
---
F
-
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
43.11
33%
-9
- C1 -
-
4L45
1
KS6B1_HUMAN
A:
[24-273]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
-
I
V
R
N
A
K
D
----
T
A
H
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
---------------
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
43.08
33%
-4
- C1 -
-
4L3L
1
KS6B1_HUMAN
A:
[24-264]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
-
I
V
R
N
A
K
D
----
T
A
H
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--
I
H
D
G
T
V
-
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
553
Blastp_CBE
42.84
32%
-3
- C1 -
-
3WE4
1
KS6B1_HUMAN
A:
[25-265]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
-
I
V
R
N
A
K
D
----
T
A
H
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--
I
H
D
--
V
-
T
H
--
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
42.67
31%
-31
- C1 -
-
6FRX
1
KAPCA_HUMAN
A:
[43-342]
-----------------------------------------------------------
Q
------
F
E
R
-----
I
R
T
L
G
T
G
S
F
G
---
R
V
M
---
L
V
---
K
H
K
E
T
G
N
H
Y
A
M
K
I
L
-
D
K
Q
K
-
V
V
K
-
L
K
Q
----
I
E
H
T
L
-
N
E
K
R
I
Q
Q
A
V
N
-
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
--
H
L
R
R
I
G
R
F
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
L
I
Y
R
D
L
K
P
E
N
L
L
I
---
D
Q
----
Q
G
Y
---
I
K
V
A
D
F
G
F
A
K
R
V
--
K
----
G
-
R
T
-
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
------
L
S
K
G
Y
-
N
K
-
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
--
F
A
-----
D
Q
P
I
--
Q
I
Y
E
--
K
I
V
S
G
K
V
R
F
P
----
S
----
H
F
S
--
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
R
FGNLK
N
-----
G
V
N
D
I
K
N
H
K
W
---
F
A
T
T
D
W
I
A
I
Y
Q
R
K
-
V
E
A
P
F
I
P
K
F
K
-
G
P
--
F
D
D
Y
E
E
E
E
I
R
V
I
N
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
549
Blastp_CBE
42.55
32%
-0
- C1 -
-
3WF8
1
KS6B1_HUMAN
A:
[25-265]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
-
I
V
R
N
A
K
D
----
T
A
H
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--
I
H
D
G
T
V
-
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
42.49
32%
5
- C1 -
-
2BMC
1
AURKA_HUMAN
A:
[30-289]
------------------------------------------------------------QWALED
F
E
I
-----
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
----------------
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
42.37
33%
-6
- C1 -
-
4L44
1
KS6B1_HUMAN
A:
[24-275]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
-
I
V
R
N
A
K
D
----
T
A
H
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--
I
H
------
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
Blastp_CBE
42.24
32%
-2
- C1 -
-
3WF9
1
KS6B1_HUMAN
A:
[25-265]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
-
I
V
R
N
A
K
D
----
T
A
H
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--
I
H
D
G
T
V
-
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
42.20
33%
-3
- C1 -
-
4L3J
1
KS6B1_HUMAN
A:
[24-264]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
-
I
V
R
N
A
K
D
----
T
A
H
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--
I
H
D
G
T
V
-
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
41.98
33%
-8
- C1 -
-
4L43
1
KS6B1_HUMAN
A:
[24-274]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
-
I
V
R
N
A
K
D
----
T
A
H
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
---------------
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
41.72
33%
-8
- C1 -
-
4L46
1
KS6B1_HUMAN
A:
[24-280]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
-
I
V
R
N
A
K
D
----
T
A
H
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--
I
H
D
-----
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
41.71
33%
0
- C1 -
-
6CPG
1
AURKA_HUMAN
D:
[9-268]
-----------------------------------------------------------
Q
------
W
A
L
EDFEI
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
----------------
L
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
Blastp_CBE
41.67
32%
3
- C1 -
-
3WF7
2
KS6B1_HUMAN
A:
[25-265]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
A
M
-
I
V
R
N
A
K
D
----
T
A
H
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--
I
H
D
--
V
-
T
H
--
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
41.63
31%
25
- C1 -
-
1Z5M
4
PDPK1_HUMAN
A:
[1-257]
-------------------------------------------------
P
R
K
---
K
R
PE
D
------
F
K
F
-----
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
41.43
31%
23
- C1 -
-
2PE0
4
PDPK1_HUMAN
A:
[1-257]
-------------------------------------------------
P
R
K
---
K
R
PE
D
------
F
K
F
-----
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
41.34
31%
24
- C1 -
-
2PE2
9
PDPK1_HUMAN
A:
[1-257]
-------------------------------------------------
P
R
K
---
K
R
PE
D
------
F
K
F
-----
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
----------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
Blastp_CBE
41.14
32%
3
- C1 -
-
3WF6
1
KS6B1_HUMAN
A:
[25-265]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
-----------------
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--
I
H
D
G
T
V
-
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
41.11
32%
-9
- C1 -
-
4EL9
1
KS6A3_MOUSE
A:
[31-288]
---------------------------------------------------------------------------
K
V
L
G
Q
G
S
F
G
---
K
V
F
LVK
K
I
---
S
G
S
D
A
R
Q
L
Y
A
M
K
V
L
-
K
K
A
T
-
L
-
K
-
V
R
D
----
R
V
------
R
D
I
L
V
E
V
N
-
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
-
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
----
E
G
H
---
I
K
L
T
D
F
G
L
-
S
K
E
--
S
---
E
K
-
K
A
Y
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
------
N
R
R
G
H
-
T
Q
-
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
--
Q
G
-----
K
D
R
K
--
E
T
M
T
--
M
I
L
K
A
K
L
G
M
P
----
Q
----
F
L
S
--
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
R
LGAGP
D
-----
G
V
E
E
I
K
R
H
S
F
---
F
-
S
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
552
Blastp_CBE
40.79
32%
2
- C1 -
-
3WF5
1
KS6B1_HUMAN
A:
[25-265]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
-----------------
T
K
-
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--
I
H
D
G
T
V
-
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
40.70
31%
26
- C1 -
-
3NUY
5
PDPK1_HUMAN
A:
[2-258]
-------------------------------------------------
P
R
K
---
K
R
PE
D
------
F
K
F
-----
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
---------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
40.69
31%
27
- C1 -
-
3NUS
5
PDPK1_HUMAN
A:
[2-258]
-------------------------------------------------
P
R
K
---
K
R
PE
D
------
F
K
F
-----
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
---------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
40.62
33%
10
- C1 -
-
6C83
1
AURKA_HUMAN
A:
[9-268]
-----------------------------------------------------------
Q
------
W
A
L
EDFEI
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
---------------------
G
T
L
D
Y
L
P
P
E
M
I
------
E
G
R
M
H
-
D
E
-
K
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
--
E
A
-----
N
T
Y
Q
--
E
T
Y
K
--
R
I
S
R
V
E
F
T
F
P
----
D
----
F
V
T
--
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
S
Q
R
-----
P
-----
M
L
R
E
V
L
E
H
P
W
---
I
-
T
A
N
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
40.49
31%
26
- C1 -
-
3NUU
4
PDPK1_HUMAN
A:
[2-258]
-------------------------------------------------
P
R
K
---
K
R
PE
D
------
F
K
F
-----
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
---------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
38.67
33%
-1
- C1 -
-
2Z7S
1
KS6A1_HUMAN
A:
[34-272]
---------------------------------------------------------------------------
K
V
L
G
Q
G
S
F
G
---
K
V
F
LVR
K
V
---
T
R
P
D
S
G
H
L
Y
A
M
K
V
L
-
K
-------------------------
I
L
A
D
V
N
-
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
-
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
----
E
G
H
---
I
K
L
T
D
F
G
L
-
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
------
N
R
Q
G
H
-
S
H
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
--
Q
G
-----
K
D
R
K
--
E
T
M
T
--
L
I
L
K
A
K
L
G
M
P
----
Q
----
F
L
S
--
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
38.10
31%
12
- C1 -
-
1H1W
8
PDPK1_HUMAN
A:
[4-260]
-------------------------------------------------
P
R
K
---
K
R
PE
D
------
F
K
F
-----
G
K
I
L
G
E
G
S
F
S
---
T
V
V
---
L
A
---
R
E
L
A
T
S
R
E
Y
A
I
K
I
L
-
E
K
R
H
-
I
I
K
-
E
N
K
----
V
P
Y
V
T
-
R
E
R
D
V
M
S
R
L
D
-
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
-
Y
I
R
K
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
I
I
H
R
D
L
K
P
E
N
I
L
L
---
N
E
----
D
M
H
---
I
Q
I
T
D
F
G
T
A
K
V
L
--
S
P
----A
R
A
-
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
------
T
E
K
S
A
-
C
K
-
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
P
P
F
--
R
A
-----
G
N
E
Y
--
L
I
F
Q
--
K
I
I
K
L
E
Y
D
F
P
----
E
----
K
F
F
--
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
R
-----
L
-----
G
C
E
E
M
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
Blastp_CBE
37.97
32%
-7
- C1 -
-
3A62
1
KS6B1_HUMAN
A:
[23-263]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
--------------------K
A
E
R
N
I
L
E
E
V
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
--------------
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
37.04
33%
-3
- C1 -
-
3A60
1
KS6B1_HUMAN
B:
[23-263]
---------------------------------------------------------------------------
R
V
L
G
K
G
G
Y
G
---
K
V
F
---
Q
V
RKV
T
G
A
N
T
G
K
I
F
A
M
K
V
L
-
K
K
-----------------------------
K
-
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
-
Q
L
E
R
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
I
I
Y
R
D
L
K
P
E
N
I
M
L
---
N
H
----
Q
G
H
---
V
K
L
T
D
F
G
L
C
K
E
S
--------------
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
R
S
G
H
-
N
R
-
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
--
T
G
-----
E
N
R
K
--
K
T
I
D
--
K
I
L
K
C
K
L
N
L
P
----
P
----
Y
L
T
--
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
36.20
33%
10
- C1 -
-
2Z7R
1
KS6A1_HUMAN
A:
[34-272]
---------------------------------------------------------------------------
K
V
L
G
Q
G
S
F
G
---
K
V
F
LVR
K
V
---
T
R
P
D
S
G
H
L
Y
A
M
K
V
L
-
K
K
A
T
-
L
-
K
-
V
----------------
I
L
A
D
V
N
-
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
-
R
L
S
K
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
I
I
Y
R
D
L
K
P
E
N
I
L
L
---
D
E
----
E
G
H
---
I
K
L
T
D
F
G
L
-
S
K
E
---------------
G
T
V
E
Y
M
A
P
E
V
V
------
N
R
Q
G
H
-
S
H
-
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
--
Q
G
-----
K
D
R
K
--
E
T
M
T
--
L
I
L
K
A
K
L
G
M
P
----
Q
----
F
L
S
--
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
31.27
34%
-109
- C1 -
-
2NP8
1
AURKA_HUMAN
A:
[17-166]
--------------------------------------------------------------------------
G
R
P
L
G
K
G
K
F
G
---
N
V
Y
---
L
A
---
R
E
K
Q
S
K
F
I
L
A
L
K
V
L
-
F
K
A
Q
-
L
E
K
-
A
G
V
----
E
H
Q
L
R
-
R
E
V
E
I
Q
S
H
L
R
-
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
-
E
L
Q
K
L
S
K
F
D
E
Q
R
T
A
T
Y
I
T
E
L
A
N
A
L
S
Y
C
H
S
-
K
R
V
I
H
R
D
I
K
P
E
N
L
L
L
---
G
S
----
A
G
E
---
L
K
I
A
D
F
G
W
S
--
V
--
H
A
P
S
S
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------