@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RIPK1_HUMAN: (2020-09-20 )
MQPDMSLNVIKMKSSDFLESAELDSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMCYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAKKNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKEPYENAICEQQLIMCIKSGNRPDVDDITEYCPREIISLMKLCWEANPEARPTFPGIEEKFRPFYLSQLEESVEEDVKSLKKEYSNENAVVKRMQSLQLDCVAVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENEPSLQSKLQDEANYHLYGSRMDRQTKQQPRQNVAYNREEERRRRVSHDPFAQQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQPQVLYQNNGLYSSHGFGTRPLDPGTAGPRVWYRPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDESIKYTIYNSTGIQIGAYNYMEIGGTSSSLLDSTNTNFKEEPAAKYQAIFDNTTSLTDKHLDPIRENLGKHWKNCARKLGFTQSQIDEIDHDYERDGLKEKVYQMLQKWVMREGIKGATVGKLAQALHQCSRIDLLSSLIYVSQN
Atome Classification :
(314 SA)
--.........10........20........30------...--..--...40-.-.......50........60........70.........80......-.------.90........100-.......---------.--------------.110.---......----------.--.120------...--------......130...--......140.......150.......160.......170.......180......-.-190.---........200.......------210.......220.-.-..-.------..230.......240..--.---.-...250--...----...-----.----.260----.........270.......280--.........290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
--MQPDM
S
L
N
V
I
K
MKSSDF
L
E
SAELDSGGFG
K
V
------
S
L
C
--
F
H--RTQ
G
L
-
M
-
I
M
K
T
VYKGPNCI
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
EEG
K
-
Y
------
S
L
V
M
E
Y
M
EKGN
L
---
M
H
V
L
K
A
E---------M--------------ST--P---LSVK
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
C
Y
LH--GKG--
V
I
HKDLKPE
N
I
L
VDND
F
H
I
K
I
ADLG
L
A
S
F
K
M
W
S
KLN
N
E
E
H
N
E
L
R
E
VDGTAKKNG
G
-
T
-
L
--
Y
---
Y
M
A
P
E
HLNDVNAKPTEK
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
FA-N-KE-
P
------
Y
E
N
A
I
C
E
Q
Q
L
I
M
C
I
KSG--N---R-P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
WEANPEARPTFP
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
EYSN
E
N
A
V
V
K
R
M
Q
SLQ
L
D
C
V
AVPSSRSNSATEQPGSLHSSQGLGMGPVEESWFAPSLEHPQEENE
P
S
L
Q
S
K
L
Q
DEAN
Y
H
L
YGSRMD
R
Q
T
K
QQPRQNVAYN
R
E
E
E
R
R
RRVSHDP
F
A
QQRPYENFQNTEGKGTAYSSAASHGNAVHQPSGLTSQ
P
Q
V
L
Y
QNNGLYSSHGFGTRPLDPGTAGP
R
V
W
Y
RPIPSHMPSLHNIPVPETNYLGNTPTMPFSSLPPTDE
S
I
K
Y
T
I
YNST
G
I
Q
I
G
A
Y
N
Y
M
E
IGGTS
S
S
LLDSTNTNFKEEP
A
A
K
Y
Q
A
I
FDNTTSL
T
D
K
H
L
D
P
I
R
E
N
L
G
K
H
W
K
N
C
A
R
KLGF
T
Q
S
Q
I
D
E
ID
H
D
Y
E
RD
G
L
K
E
K
V
Y
Q
M
L
Q
K
W
V
M
REGIKGA
T
V
G
K
L
A
Q
A
L
H
Q
C
S
R
I
D
L
L
S
S
L
I
YVSQN
556
HHSearch
93.80
100%
-117
- C4 -
-
4NEU
1
RIPK1_HUMAN
A:
[15-322]
-------
S
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
------
S
L
C
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
C
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
----------------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
C
E
Q
Q
L
I
M
C
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
E
Y
S
N
E
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
93.80
100%
-117
- C4 -
-
4NEU
1
RIPK1_HUMAN
A:
[15-322]
-------
S
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
------
S
L
C
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
C
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
----------------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
C
E
Q
Q
L
I
M
C
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
E
Y
S
N
E
N
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
90.69
99%
-117
- C4 -
-
4ITJ
1
RIPK1_HUMAN
B:
[7-294]
--------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-------------
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
557
HHSearch
90.57
99%
-119
- C4 -
-
4ITJ
1
RIPK1_HUMAN
B:
[7-293]
--------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-------------
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
90.54
100%
-122
- C4 -
-
4NEU
1
RIPK1_HUMAN
B:
[16-319]
--------
L
N
V
I
K
M
-------
S
A
E
L
D
S
G
G
F
G
K
V
------
S
L
C
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
C
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
------------------------------
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
C
E
Q
Q
L
I
M
C
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
E
S
V
E
E
D
V
K
S
L
K
K
E
Y
S
N
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
89.96
99%
-120
- C4 -
-
6OCQ
1
RIPK1_HUMAN
B:
[16-303]
--------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
--
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-------------
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
89.40
98%
-133
- C4 -
-
4ITI
1
RIPK1_HUMAN
A:
[8-294]
---------
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
----------
G
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
-----
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
89.24
99%
-143
- C4 -
-
6C4D
1
RIPK1_HUMAN
D:
[8-296]
------
M
S
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
-------
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
----------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
89.24
99%
-142
- C4 -
-
6HHO
1
RIPK1_HUMAN
B:
[16-303]
--------
L
N
V
I
K
M
K
S
S
D
F
L
----------
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-------------
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
88.79
98%
-141
- C4 -
-
5HX6
1
RIPK1_HUMAN
A:
[19-303]
-----------
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
---
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
-----
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
88.56
98%
-134
- C4 -
-
4ITJ
1
RIPK1_HUMAN
A:
[8-294]
---------
N
V
I
K
M
K
S
S
D
F
L
E
--------
F
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
88.44
99%
-130
- C4 -
-
6C4D
1
RIPK1_HUMAN
B:
[10-297]
--------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
------
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
----------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
88.37
98%
-134
- C4 -
-
5TX5
1
RIPK1_HUMAN
A:
[19-303]
-----------
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
--
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
------
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
88.08
99%
-128
- C4 -
-
4ITI
1
RIPK1_HUMAN
B:
[7-294]
--------
L
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
-------
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-----------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
87.97
98%
-127
- C4 -
-
6C4D
1
RIPK1_HUMAN
A:
[11-297]
---------
N
V
I
K
M
K
S
S
D
F
L
E
-------
G
F
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
-------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
87.93
99%
-141
- C4 -
-
5HX6
1
RIPK1_HUMAN
B:
[18-303]
----------
V
I
K
M
K
S
S
D
F
L
E
S
----------
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-------------
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
87.83
98%
-132
- C4 -
-
6NYH
1
RIPK1_HUMAN
A:
[10-296]
---------
N
V
I
K
M
K
S
S
D
F
L
E
----------
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
87.67
99%
-147
- C4 -
-
6R5F
1
RIPK1_HUMAN
B:
[19-303]
-----------
I
K
M
K
S
S
D
F
L
------------
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
-----------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
87.51
98%
-120
- C4 -
-
6HHO
1
RIPK1_HUMAN
A:
[17-303]
---------
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
---
F
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-----------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.10
98%
-139
- C4 -
-
6NW2
1
RIPK1_HUMAN
A:
[24-310]
---------
N
V
I
K
M
K
S
S
D
F
L
-----------
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-------------
T
-
L
--
Y
---
Y
M
A
P
E
H
L
----
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
87.04
99%
-127
- C4 -
-
6RLN
1
RIPK1_HUMAN
B:
[16-303]
--------
L
N
V
I
K
M
K
S
S
D
F
L
-----------
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-------------
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
87.01
99%
-134
- C4 -
-
6C4D
1
RIPK1_HUMAN
C:
[13-297]
-----------
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
-----
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
----
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
86.85
98%
-136
- C4 -
-
6C3E
1
RIPK1_HUMAN
B:
[13-297]
-----------
I
K
M
K
S
S
D
F
L
E
S
A
E
-------
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
-------------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
L
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
86.77
98%
-137
- C4 -
-
6RLN
1
RIPK1_HUMAN
A:
[17-303]
---------
N
V
I
K
M
K
S
S
D
F
L
E
----------
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-----------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
86.70
98%
-118
- C4 -
-
6OCQ
1
RIPK1_HUMAN
A:
[17-303]
---------
N
V
I
K
M
K
S
S
D
F
L
E
S
A
E
------
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
--------------------
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
86.29
98%
-132
- C4 -
-
6C3E
1
RIPK1_HUMAN
A:
[12-296]
----------
V
I
K
M
K
S
S
D
F
L
E
S
A
E
L
D
S
G
G
F
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
----
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
-----------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
------
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
L
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
86.13
99%
-132
- C4 -
-
5TX5
1
RIPK1_HUMAN
B:
[18-303]
----------
V
I
K
M
K
S
S
D
F
L
E
S
-----------------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
H
N
E
L
-------------
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
86.01
99%
-146
- C4 -
-
6R5F
1
RIPK1_HUMAN
D:
[20-303]
------------
K
M
K
S
S
D
F
L
------------
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
-----
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
-----------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
84.61
99%
-150
- C4 -
-
6R5F
1
RIPK1_HUMAN
C:
[18-303]
----------
V
I
K
M
K
S
S
D
F
L
-----------
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
Y
K
------
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
----------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
84.44
98%
-130
- C4 -
-
6R5F
1
RIPK1_HUMAN
A:
[18-303]
----------
V
I
K
M
K
S
S
D
---------------------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
---
G
P
N
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
N
E
E
-----------------
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
84.19
99%
-144
- C4 -
-
6NW2
1
RIPK1_HUMAN
B:
[27-310]
------------
K
M
K
S
S
D
F
L
----------
G
K
V
------
S
L
A
--
F
H
--
R
T
Q
G
L
-
M
-
I
M
K
T
V
-----
C
I
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
--
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
E
---------
M
--------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
---
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
84.10
99%
-140
- C4 -
-
6NYH
1
RIPK1_HUMAN
B:
[13-296]
------------
K
M
K
S
S
D
F
L
E
S
---------
K
V
------
S
L
A
--
F
H
----
Q
G
L
-
M
-
I
M
K
T
V
-------
E
H
N
E
A
L
L
E
E
A
K
M
M
N
R
L
-
R
H
S
R
V
V
K
L
L
G
V
I
I
E
E
G
K
-
Y
------
S
L
V
M
E
Y
M
E
K
G
N
L
---
M
H
V
L
K
A
-------------------------
S
T
--
P
---
L
S
V
K
G
R
----------
I
--
I
L
--------
E
I
I
--------
E
G
M
A
Y
L
H
--
G
K
G
--
V
I
H
K
D
L
K
P
E
N
I
L
V
D
N
D
F
H
I
K
I
A
D
L
G
L
A
S
F
K
M
W
S
K
L
N
------------------
G
-
T
-
L
--
Y
---
Y
M
A
P
E
H
L
N
D
V
N
A
K
P
T
E
K
S
------
D
V
Y
S
F
A
V
V
L
W
A
I
F
A
-
N
-
K
E
-
P
------
Y
E
N
A
I
A
E
Q
Q
L
I
M
A
I
K
S
G
--
N
---
R
-
P
D
V
D
D
---
I
T
E
----
Y
C
P
-----
R
----
E
I
------
I
S
L
M
K
L
C
W
E
A
N
P
E
A
R
P
T
F
P
G
----
I
E
E
K
F
R
P
F
Y
L
S
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
58.49
33%
-58
- C4 -
-
3VS6
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------------
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
57.94
33%
-61
- C4 -
-
3VS6
1
HCK_HUMAN
B:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------------
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
57.75
33%
-53
- C4 -
-
3VS5
1
HCK_HUMAN
B:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
57.64
33%
-57
- C4 -
-
3VS2
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
57.51
33%
-54
- C4 -
-
3VRY
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------------
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
140
Blastp_CBE
57.11
32%
-43
- C4 -
-
3BYO
1
?
A:
[21-270]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
E
G
A
K
-
F
P
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
57.09
33%
-50
- C4 -
-
3VS3
1
HCK_HUMAN
B:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
----------
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
57.08
33%
-54
- C4 -
-
3VRY
1
HCK_HUMAN
B:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------------
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
56.91
33%
-53
- C4 -
-
3VS0
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
56.82
33%
-51
- C4 -
-
3VS3
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------------
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
56.72
33%
-56
- C4 -
-
4LUD
2
HCK_HUMAN
B:
[195-452]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
--
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
56.70
33%
-56
- C4 -
-
3VS4
1
HCK_HUMAN
B:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
------------------------
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
56.64
32%
-39
- C4 -
-
1QPC
2
?
A:
[21-270]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
E
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
56.62
33%
-53
- C4 -
-
3VS0
1
HCK_HUMAN
B:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
56.47
33%
-55
- C4 -
-
3VS2
1
HCK_HUMAN
B:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
560
HHSearch
56.41
32%
-30
- C4 -
-
5WNL
1
RIPK4_MOUSE
A:
[17-284]
-------------
F
D
A
G
E
F
A
G
W
E
K
V
G
S
G
G
F
G
Q
V
------
Y
K
V
--
R
H
--
V
H
W
K
T
W
L
-
A
I
K
C
S
P
---
V
D
D
R
E
R
M
E
L
L
E
E
A
K
K
M
E
M
A
-
K
F
R
Y
I
L
P
V
Y
G
I
C
Q
--
E
P
-
V
------
G
L
V
M
E
Y
M
E
T
G
S
L
---
E
K
L
L
A
S
E
------------------------
P
L
--
P
---
W
D
L
R
F
R
----------
I
--
V
H
--------
E
T
A
--------
V
G
M
N
F
L
H
CM
S
P
P
--
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
K
I
S
D
F
G
L
A
K
C
------------------------
F
G
-
T
-
I
--
A
---
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
K
H
------
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
-
Q
-
K
K
-
P
------
F
A
D
E
K
N
I
L
H
I
M
M
K
V
V
K
G
--
H
---
R
-
P
E
L
P
P
ICR
P
R
P
----
R
A
C
-----
A
----
S
L
------
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
----
I
T
S
E
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
56.41
32%
-43
- C4 -
-
1QPJ
1
LCK_HUMAN
A:
[21-270]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
E
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
56.32
32%
-39
- C4 -
-
1QPE
1
LCK_HUMAN
A:
[21-270]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
E
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
56.11
32%
-39
- C4 -
-
3BYM
1
LCK_HUMAN
A:
[22-271]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
E
G
A
K
-
F
P
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
56.09
32%
-39
- C4 -
-
2PL0
1
LCK_HUMAN
A:
[31-278]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
56.08
32%
-34
- C4 -
-
2OF4
1
LCK_HUMAN
A:
[21-270]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
56.01
33%
-42
- C4 -
-
5H0G
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
55.81
33%
-52
- C4 -
-
4LUE
3
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
---------
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
55.78
32%
-58
- C4 -
-
5XY1
1
LYN_HUMAN
A:
[20-269]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
N
S
T
K
-
V
-
A
V
K
T
L
K
P
G
T
M
S
V
Q
---
A
F
L
E
E
A
N
L
M
K
T
L
-
Q
H
D
K
L
V
R
L
Y
A
V
V
T
R
E
E
P
-
I
------
Y
I
I
T
E
Y
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
-----------
G
K
----------
V
--
L
L
PKLIDFSA
Q
I
A
--------
E
G
M
A
Y
I
E
--
R
K
N
--
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
E
S
L
M
C
K
I
A
D
F
G
L
A
R
V
--------------------
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
C
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
Y
G
-
K
I
-
P
------
Y
P
G
R
-
T
N
A
D
V
M
T
A
L
S
Q
G
--
Y
---
R
M
P
R
V
E
N
-----------
C
P
-----
D
----
E
L
------
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
----
L
Q
S
V
L
D
D
F
Y
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
55.56
33%
-41
- C4 -
-
5H0B
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
55.54
33%
-56
- C4 -
-
3VS7
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
---------------------------
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
55.46
33%
-57
- C4 -
-
4LUE
3
HCK_HUMAN
B:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
-----------
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
A
I
N
-----
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
55.42
33%
-38
- C4 -
-
1QCF
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
55.41
32%
-49
- C4 -
-
5ZJ6
1
HCK_HUMAN
A:
[33-283]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
55.26
33%
-38
- C4 -
-
5H09
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
55.17
31%
-48
- C4 -
-
3MPM
2
LCK_HUMAN
A:
[17-264]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
N
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
R
----
F
P
------
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
---
R
-
M
V
R
P
D
----------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
55.12
33%
-41
- C4 -
-
5H0E
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
55.06
33%
-41
- C4 -
-
5H0H
1
HCK_HUMAN
A:
[195-451]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
T
--
E
S
Q
E
E
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
Blastp_CBE
54.94
32%
-40
- C4 -
-
3B2W
1
LCK_HUMAN
A:
[26-275]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
T
A
--
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
54.91
32%
-46
- C4 -
-
5ZJ6
1
HCK_HUMAN
B:
[33-283]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
54.03
32%
-43
- C4 -
-
2OG8
1
?
B:
[16-265]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
------------------------
P
------
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
54.02
33%
-9
- C4 -
-
5WNJ
1
RIPK4_MOUSE
A:
[19-289]
---------------
A
G
E
F
A
G
W
E
K
V
G
S
--
F
G
Q
V
------
Y
K
V
RH
V
H
--
W
K
T
W
L
-
A
-
I
K
C
S
P
S
L
H
V
D
D
R
E
R
M
E
-
L
L
E
E
A
K
K
M
E
M
A
-
K
F
R
Y
I
L
P
V
Y
G
I
C
Q
E
--
P
-
V
------
G
L
V
M
E
Y
M
E
T
G
S
L
---
E
K
L
L
A
S
E
------------------------
P
L
--
P
---
W
D
L
R
F
R
----------
I
--
V
H
--------
E
T
A
--------
V
G
M
N
F
L
H
--
C
M
S
PP
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
K
I
S
D
F
G
L
A
------
K
C
--------------
F
----
G
-
T
-
I
--
A
---
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
K
H
------
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
-
Q
-
K
K
-
P
------
F
A
D
E
K
N
I
L
H
I
M
M
K
V
V
K
G
--
H
---
R
-
P
E
L
P
P
---
I
C
R
----
P
R
P
-----
R
ACA-
S
L
------
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
----
I
T
S
E
-----
T
E
D
L
C
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
53.81
31%
-64
- C4 -
-
5D12
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
--------
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
53.80
32%
-46
- C4 -
-
3BYU
1
LCK_HUMAN
A:
[27-276]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-----------------------
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
53.78
31%
-51
- C4 -
-
4YBK
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
-------------------------
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
554
Blastp_CBE
53.76
31%
-40
- C4 -
-
4K11
1
SRC_HUMAN
A:
[188-439]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
G
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
Q
G
A
K
-
F
P
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
53.72
33%
-12
- C4 -
-
5WNK
1
RIPK4_MOUSE
A:
[19-288]
---------------
A
G
E
F
A
G
W
E
K
V
G
S
--
F
G
Q
V
------
Y
K
V
RH
V
H
--
W
K
T
W
L
-
A
-
I
K
C
S
P
S
L
H
V
D
D
R
E
R
M
E
-
L
L
E
E
A
K
K
M
E
M
A
-
K
F
R
Y
I
L
P
V
Y
G
I
C
Q
E
--
P
-
V
------
G
L
V
M
E
Y
M
E
T
G
S
L
---
E
K
L
L
A
S
E
------------------------
P
L
--
P
---
W
D
L
R
F
R
----------
I
--
V
H
--------
E
T
A
--------
V
G
M
N
F
L
H
--
C
M
S
PP
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
K
I
S
D
F
G
L
A
------
K
C
--------------
F
----
G
-
T
-
I
--
A
---
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
K
H
------
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
-
Q
-
K
K
-
P
------
F
A
D
E
K
N
I
L
H
I
M
M
K
V
V
K
G
--
H
---
R
-
P
E
L
P
P
---
I
C
R
----
P
R
P
-----
R
ACA-
S
L
------
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
----
I
T
S
E
-----
T
E
D
L
C
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
53.70
31%
-50
- C4 -
-
5XP5
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
-------------
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
372
Blastp_CBE
53.49
31%
-49
- C4 -
-
4U5J
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
-------------
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
53.32
31%
-48
- C4 -
-
3DQW
1
SRC_CHICK
D:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
I
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
Q
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
53.30
31%
-51
- C4 -
-
4MCV
1
SRC_CHICK
A:
[16-267]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
G
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
----------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
53.25
31%
-50
- C4 -
-
3DQW
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
I
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
Q
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
53.21
31%
-59
- C4 -
-
4MXY
1
SRC_HUMAN
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
L
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
53.21
31%
-59
- C4 -
-
4MXZ
1
SRC_HUMAN
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
L
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
53.13
31%
-46
- C4 -
-
3DQX
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
-------------
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
53.13
31%
-45
- C4 -
-
3DQW
1
SRC_CHICK
C:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
I
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
Q
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
53.11
33%
-6
- C4 -
-
5WNM
1
RIPK4_MOUSE
A:
[19-289]
---------------
A
G
E
F
A
G
W
E
K
V
G
S
--
F
G
Q
V
------
Y
K
V
RH
V
H
--
W
K
T
W
L
-
A
-
I
K
C
S
P
S
L
H
V
D
D
R
E
R
M
E
-
L
L
E
E
A
K
K
M
E
M
A
-
K
F
R
Y
I
L
P
V
Y
G
I
C
Q
E
--
P
-
V
------
G
L
V
M
E
Y
M
E
T
G
S
L
---
E
K
L
L
A
S
E
------------------------
P
L
--
P
---
W
D
L
R
F
R
----------
I
--
V
H
--------
E
T
A
--------
V
G
M
N
F
L
H
--
C
M
S
PP
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
K
I
S
D
F
G
L
A
------
K
---------------
F
----
G
-
T
-
I
--
A
---
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
K
H
------
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
-
Q
-
K
K
-
P
------
F
A
D
E
K
N
I
L
H
I
M
M
K
V
V
K
G
--
H
---
R
-
P
E
L
P
P
---
I
C
R
----
P
R
P
-----
R
ACA-
S
L
------
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
----
I
T
S
E
-----
T
E
D
L
C
E
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
395
Blastp_CBE
53.05
31%
-48
- C4 -
-
3EN4
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
------------------------
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
564
HHSearch
52.94
33%
-16
- C4 -
-
5WNI
1
RIPK4_MOUSE
A:
[18-284]
--------------
D
A
G
E
F
A
G
W
E
K
V
G
S
----
Q
V
------
Y
K
V
--
R
H
--
V
H
W
K
T
-
W
L
A
I
K
C
S
P
S
L
H
V
D
D
R
E
R
M
E
L
L
E
E
A
K
K
M
E
M
A
-
K
F
R
Y
I
L
P
V
Y
G
I
C
Q
--
E
P
-
V
------
G
L
V
M
E
Y
M
E
T
G
S
L
---
E
K
L
L
A
S
E
------------------------
P
L
--
P
---
W
D
L
R
F
R
----------
I
--
V
H
--------
E
T
A
--------
V
G
M
N
F
L
H
CM
S
P
P
--
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
K
I
S
D
F
G
L
A
K
C
N
-----------------------
F
G
-
T
-
I
--
A
---
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
K
H
------
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
-
Q
-
K
K
-
P
------
F
A
D
E
K
N
I
L
H
I
M
M
K
V
V
K
G
--
H
---
R
-
P
E
L
P
P
ICR
P
R
P
----
R
A
C
-----
A
----
S
L
------
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
----
I
T
S
E
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
52.94
31%
-57
- C4 -
-
5T0P
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
C
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
52.85
31%
-49
- C4 -
-
5XP5
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
-------------
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
52.83
31%
-45
- C4 -
-
1Y57
1
SRC_HUMAN
A:
[190-441]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
Q
G
A
K
-
F
P
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
52.77
31%
-44
- C4 -
-
3DQX
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
------------
Q
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
52.76
31%
-52
- C4 -
-
3GEQ
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
52.72
31%
-60
- C4 -
-
5T0P
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
C
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
52.72
33%
-8
- C4 -
-
5WNL
1
RIPK4_MOUSE
A:
[19-288]
---------------
A
G
E
F
A
G
W
E
K
V
G
S
G
G
F
G
Q
V
------
Y
K
V
RH
V
H
--
W
K
T
W
L
-
A
-
I
K
C
S
P
---
V
D
D
R
E
R
M
E
-
L
L
E
E
A
K
K
M
E
M
A
-
K
F
R
Y
I
L
P
V
Y
G
I
C
Q
E
--
P
-
V
------
G
L
V
M
E
Y
M
E
T
G
S
L
---
E
K
L
L
A
S
E
------------------------
P
L
--
P
---
W
D
L
R
F
R
----------
I
--
V
H
--------
E
T
A
--------
V
G
M
N
F
L
H
--
C
M
S
PP
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
K
I
S
D
F
G
L
A
------
K
C
--------------
F
----
G
-
T
-
I
--
A
---
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
K
H
------
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
-
Q
-
K
K
-
P
------
F
A
D
E
K
N
I
L
H
I
M
M
K
V
V
K
G
--
H
---
R
-
P
E
L
P
P
---
I
C
R
----
P
R
P
-----
R
ACA-
S
L
------
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
----
I
T
S
E
-----
T
E
D
L
C
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
52.71
31%
-54
- C4 -
-
6HVE
1
?
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
----------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
52.69
31%
-41
- C4 -
-
2SRC
1
SRC_HUMAN
A:
[190-441]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
Q
G
A
K
-
F
P
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
561
HHSearch
52.65
32%
-25
- C4 -
-
5WNJ
1
RIPK4_MOUSE
A:
[17-284]
-------------
F
D
A
G
E
F
A
G
W
E
K
V
G
S
--
F
G
Q
V
------
Y
K
V
--
R
H
--
V
H
W
K
T
-
W
L
A
I
K
C
S
P
S
L
H
V
D
D
R
E
R
M
E
L
L
E
E
A
K
K
M
E
M
A
-
K
F
R
Y
I
L
P
V
Y
G
I
C
Q
--
E
P
-
V
------
G
L
V
M
E
Y
M
E
T
G
S
L
---
E
K
L
L
A
S
E
------------------------
P
L
--
P
---
W
D
L
R
F
R
----------
I
--
V
H
--------
E
T
A
--------
V
G
M
N
F
L
H
CM
S
P
P
--
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
K
I
S
D
F
G
L
A
K
C
------------------------
F
G
-
T
-
I
--
A
---
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
K
H
------
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
-
Q
-
K
K
-
P
------
F
A
D
E
K
N
I
L
H
I
M
M
K
V
V
K
G
--
H
---
R
-
P
E
L
P
P
ICR
P
R
P
----
R
A
C
-----
A
----
S
L
------
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
----
I
T
S
E
T
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
52.53
31%
-47
- C4 -
-
2BDF
1
SRC_HUMAN
A:
[17-268]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
----------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
52.48
32%
-46
- C4 -
-
3BYS
1
LCK_HUMAN
A:
[27-276]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
------------------------------
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
52.45
31%
-65
- C4 -
-
3TZ9
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
52.40
32%
-42
- C4 -
-
2HK5
1
HCK_HUMAN
A:
[22-269]
-----------------------
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
--
N
K
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
S
V
E
---
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
E
P
I
-
Y
-------
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
D
---------
E
--------------
G
S
KQ
P
---
L
P
K
L
I
D
----------
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
--------
E
D
N
E
Y
T
A
R
E
G
A
K
----
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
F
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
Y
G
-
R
I
-
P
------
Y
P
-
G
M
S
N
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
M
P
R
-------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
52.33
31%
-46
- C4 -
-
3F6X
1
SRC_CHICK
C:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
-------
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
---------------
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
361
Blastp_CBE
52.33
31%
-50
- C4 -
-
5XP7
2
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
343
Blastp_CBE
52.33
31%
-47
- C4 -
-
3DQW
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
I
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
Q
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
52.28
31%
-51
- C4 -
-
4O2P
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
-
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
-------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
52.25
31%
-47
- C4 -
-
3F6X
1
SRC_CHICK
D:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
---------------
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
52.25
31%
-44
- C4 -
-
5XP7
2
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
----------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
52.23
31%
-56
- C4 -
-
3UQG
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
52.21
31%
-66
- C4 -
-
3TZ9
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
52.17
31%
-59
- C4 -
-
3UQF
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
-----------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
52.16
32%
-44
- C4 -
-
2OG8
1
LCK_HUMAN
A:
[16-264]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
-------------------------
P
------
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
52.15
31%
-55
- C4 -
-
3QLG
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
I
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
52.11
31%
-50
- C4 -
-
3F6X
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
--------
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
---------------
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
51.97
31%
-61
- C4 -
-
3F3U
2
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
51.83
31%
-50
- C4 -
-
3D7T
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
------------------------
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
51.64
31%
-53
- C4 -
-
3GEQ
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
51.60
31%
-48
- C4 -
-
2BDJ
1
SRC_HUMAN
A:
[17-267]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
----------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
51.60
31%
-63
- C4 -
-
3F3W
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
51.60
31%
-62
- C4 -
-
5D11
2
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
------
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
371
Blastp_CBE
51.53
31%
-40
- C4 -
-
4U5J
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
-------------
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
555
Blastp_CBE
51.47
31%
-42
- C4 -
-
1KSW
1
SRC_HUMAN
A:
[190-441]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
G
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------
E
D
N
E
Y
-----
T
A
R
Q
G
A
K
-
F
P
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
51.48
31%
-60
- C4 -
-
3EN5
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
377
Blastp_CBE
51.48
31%
-59
- C4 -
-
4DGG
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
---------
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
51.47
31%
-55
- C4 -
-
5SWH
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
C
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
51.42
31%
-52
- C4 -
-
3F6X
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
-
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
------------------------
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
51.40
31%
-50
- C4 -
-
3EL8
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
51.36
31%
-53
- C4 -
-
5SWH
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
C
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
51.30
31%
-58
- C4 -
-
3F3T
2
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
51.25
31%
-61
- C4 -
-
3F3W
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
Blastp_CBE
51.21
32%
-42
- C4 -
-
2OFV
1
LCK_HUMAN
A:
[26-273]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
----------
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
-------------------------------
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
51.15
31%
-48
- C4 -
-
3G6G
3
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
---------------------------
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
51.14
31%
-57
- C4 -
-
3TZ8
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
51.00
31%
-62
- C4 -
-
3F3V
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
51.00
31%
-59
- C4 -
-
3G5D
2
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
---
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
------
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
50.90
31%
-61
- C4 -
-
5D11
2
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
------------
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
396
Blastp_CBE
50.70
31%
-49
- C4 -
-
3EN4
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
-----
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
50.56
31%
-51
- C4 -
-
4DGG
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
50.56
33%
-60
- C4 -
-
6NVH
1
A:
[69-292]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
RPPGSSEGP
L
--------------
S
F
--
P
---
V
L
V
S
------------
C
--
A
Y
--------
Q
V
A
--------
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------------------
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
50.55
31%
-39
- C4 -
-
3MJ2
1
A:
[14-251]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
S
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
---------------
D
D
Q
Y
T
S
S
T
G
-
T
-
K
--
F
PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
50.50
31%
-52
- C4 -
-
3F3U
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
-----
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
50.51
31%
-37
- C4 -
-
4M14
2
A:
[17-254]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
---------------
D
D
Q
Y
T
S
S
T
G
-
T
-
K
--
F
PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
50.50
31%
-51
- C4 -
-
5K9I
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
50.47
31%
-52
- C4 -
-
5SYS
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
C
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
50.40
31%
-58
- C4 -
-
3G6H
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
I
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
50.35
31%
-63
- C4 -
-
3F3V
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
50.34
31%
-35
- C4 -
-
4M15
2
A:
[17-254]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
---------------
D
D
Q
Y
T
S
S
T
G
-
T
-
K
--
F
PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
50.30
33%
-8
- C4 -
-
5WNI
1
RIPK4_MOUSE
A:
[19-288]
---------------
A
G
E
F
A
G
W
E
K
V
G
S
----
Q
V
------
Y
K
V
RH
V
H
--
W
K
T
W
L
-
A
-
I
K
C
S
P
S
L
H
V
D
D
R
E
R
M
E
-
L
L
E
E
A
K
K
M
E
M
A
-
K
F
R
Y
I
L
P
V
Y
G
I
C
Q
E
--
P
-
V
------
G
L
V
M
E
Y
M
E
T
G
S
L
---
E
K
L
L
A
S
E
------------------------
P
L
--
P
---
W
D
L
R
F
R
----------
I
--
V
H
--------
E
T
A
--------
V
G
M
N
F
L
H
--
C
M
S
PP
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
K
I
S
D
F
G
L
A
------
K
C
N
-------------
F
----
G
-
T
-
I
--
A
---
Y
L
P
P
E
R
I
R
E
K
S
R
L
F
D
T
K
H
------
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
-
Q
-
K
K
-
P
------
F
A
D
E
K
N
I
L
H
I
M
M
K
V
V
K
G
--
H
---
R
-
P
E
L
P
P
---
I
C
R
----
P
R
P
-----
R
ACA-
S
L
------
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
----
I
T
S
E
-----
T
E
D
L
C
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
50.26
31%
-66
- C4 -
-
5D12
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
----------
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
-----------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
50.22
31%
-31
- C4 -
-
4M12
1
A:
[17-254]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
---------------
D
D
Q
Y
T
S
S
T
G
-
T
-
K
--
F
PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
50.20
33%
-36
- C4 -
-
5J7B
1
RIPK2_HUMAN
A:
[79-326]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
----------------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
----
S
RASIKH
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
576
Fugue
50.10
32%
35
- C4 -
-
1QCF
1
HCK_HUMAN
A:
[173-454]
KP
Q
K
P
-
W
E
K
D
A
W
E
I
P
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
------
W
M
A
--
T
Y
NK--
H
T
K
-
V
-
A
V
K
T
M
K
P
G
S
M
---
S
V
E
A
F
L
A
E
A
N
V
M
K
T
L
-
Q
H
D
K
L
V
K
L
H
A
V
V
T
K
--
E
P
I
------
Y
I
I
T
E
F
M
A
K
G
S
L
---
L
D
F
L
K
S
------------------------------------
D
E
G
SKQPLPKLID
F
--
S
A
--------
Q
I
A
--------
E
G
M
A
F
I
E
--
Q
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
A
S
L
V
C
K
I
A
D
F
G
L
A
R
V
I
E
D
N
E
Y
T
A
R
E
G
------------
A
K
F
-
P
-
I
--
K
---
W
T
A
P
E
A
I
N
F
--
G
S
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
M
E
I
V
T
-
Y
G
R
I
-
P
------
Y
P
G
M
S
N
-
P
E
V
I
R
A
L
E
R
G
--
Y
---
R
-
M
P
R
------
P
E
----
N
C
P
-----
E
----
E
L
------
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
----
I
Q
S
V
L
D
D
F
Y
T
--
A
T
E
S
Q
E
E
I
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
50.06
31%
-39
- C4 -
-
4M0Y
2
A:
[17-254]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
---------------
D
D
Q
Y
T
S
S
T
G
-
T
-
K
--
F
PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
50.01
31%
-52
- C4 -
-
5J5S
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
--
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
49.94
33%
-37
- C4 -
-
6S1F
1
?
A:
[63-311]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
------------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
G
Q
K
-KH----
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
49.89
31%
-46
- C4 -
-
1YOL
1
SRC_HUMAN
B:
[21-272]
----------------------
V
K
L
G
Q
G
--
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
N
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
SA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------------
P
-
I
--
K
---
W
T
A
P
E
A
--
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
49.83
31%
-55
- C4 -
-
1YOM
1
SRC_HUMAN
B:
[21-272]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
N
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
SA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------------F
P
-
I
--
K
---
W
T
A
P
E
A
--
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
49.84
31%
-55
- C4 -
-
3TZ8
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
----------------------------
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
49.83
31%
-39
- C4 -
-
3T9T
3
A:
[15-252]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
T
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
---------------
D
D
Q
Y
T
S
S
T
G
-
T
-
K
--
F
PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
49.81
31%
-54
- C4 -
-
3G5D
2
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
---
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
--------
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
--------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
49.79
31%
-51
- C4 -
-
5SYS
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
C
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
49.75
31%
-49
- C4 -
-
1YOL
1
SRC_HUMAN
A:
[21-272]
----------------------
V
K
L
G
Q
G
--
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
N
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
SA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------------
P
-
I
--
K
---
W
T
A
P
E
A
--
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
49.74
31%
-56
- C4 -
-
4KIO
3
ITK_HUMAN
C:
[14-251]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
----------------------------------
F
PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
49.66
33%
-30
- C4 -
-
6UL8
1
?
B:
[59-306]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
C
K
W
-------------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
G
Q
K
S
RASIKH
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
49.60
31%
-53
- C4 -
-
6ATE
1
SRC_HUMAN
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
---------
P
E
A
F
--
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
49.59
31%
-49
- C4 -
-
5TEH
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
C
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
49.55
31%
-53
- C4 -
-
4RFM
1
A:
[14-251]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
S
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
---------------------------------PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
49.49
31%
-33
- C4 -
-
4M13
1
A:
[17-254]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
---------------
D
D
Q
Y
T
S
S
T
G
-
T
-
K
--
F
PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
49.49
32%
-37
- C4 -
-
2ZM1
2
LCK_HUMAN
A:
[27-276]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------
R
L
I
E
D
N
E
T
A
R
E
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
49.43
31%
-57
- C4 -
-
3SVV
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
---
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
----
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
C
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
49.43
33%
-34
- C4 -
-
6S1F
1
?
B:
[63-311]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
M
M
S
-----------------------
T
-
I
--
I
---
Y
M
P
P
E
-----------
K
S
RASIKH
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
49.35
33%
-19
- C4 -
-
5J79
1
RIPK2_HUMAN
A:
[79-326]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
M
----------
S
A
P
E
--------
G
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
----SIKH--
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
49.31
31%
-64
- C4 -
-
2QQ7
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
-
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
--------------
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
49.29
31%
-52
- C4 -
-
1YOM
1
SRC_HUMAN
A:
[21-272]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
N
K
G
S
L
---
L
D
F
L
K
G
E
---------
T
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
SA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------------F
P
-
I
--
K
---
W
T
A
P
E
A
--
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
49.27
31%
-52
- C4 -
-
3UQF
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
----------
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
49.23
33%
-32
- C4 -
-
6S1F
1
?
D:
[63-311]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
-------------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
------ASIKH-
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
49.16
31%
-68
- C4 -
-
1SM2
1
B:
[12-249]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------------------
F
PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
49.11
31%
-66
- C4 -
-
4KIO
3
D:
[14-251]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
--------
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
------------------------------------PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
49.07
31%
-61
- C4 -
-
3UQG
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
----
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
-------
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
I
--------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
49.07
31%
-64
- C4 -
-
5D10
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
----------------
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
49.05
33%
-25
- C4 -
-
5AR3
1
RIPK2_HUMAN
B:
[79-326]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
M
-------------------------
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
----ASIKH-
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
49.02
31%
-35
- C4 -
-
4M0Z
2
A:
[17-254]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
R
F
V
L
---------------
D
D
Q
Y
T
S
S
T
G
-
T
-
K
--
F
PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
R
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
48.98
31%
-52
- C4 -
-
3EL7
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
--
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
----
T
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
--
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
-------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
48.95
33%
-28
- C4 -
-
5AR4
1
RIPK2_HUMAN
B:
[79-326]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
----------------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
G
Q
K
S
RASIKH
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
376
Blastp_CBE
48.93
31%
-57
- C4 -
-
4FIC
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
---
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
-----------
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
48.85
33%
-17
- C4 -
-
6SZE
1
?
B:
[64-311]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
---------------
E
--------
G
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
----SIKH--
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
48.79
31%
26
- C4 -
-
3LW0
3
IGF1R_HUMAN
A:
[20-303]
---------------------
S
R
E
L
G
Q
G
S
F
G
M
V
YEGVAK
G
V
V
--
K
D
--
E
P
E
T
R
-
V
-
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
-
T
------
L
V
I
M
E
L
M
T
R
G
D
L
KSY
L
R
S
L
R
P
-----------------------------
P
---
P
S
L
S
K
M
----------
I
--
Q
M
AG------
E
I
A
--------
D
G
M
A
Y
L
N
--
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
-
L
-
L
PV
R
---
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
LL
D
---
K
-
P
D
-------------
N
C
P
-----
D
----
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
48.69
33%
-17
- C4 -
-
6S1F
1
?
C:
[63-311]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
------------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
----SIKH--
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
48.63
33%
-26
- C4 -
-
5AR5
1
RIPK2_HUMAN
B:
[79-326]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
--------------------------
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
-----SIKH--
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
48.48
31%
-65
- C4 -
-
3LOK
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
---
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
---------------
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
A
R
L
---------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
48.37
33%
-65
- C4 -
-
6NVJ
1
A:
[69-292]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
RPPGSSEGP
L
--------------
S
F
--
P
---
V
L
V
S
------------
C
--
A
Y
--------
Q
V
A
--------
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
48.33
31%
-59
- C4 -
-
3EN5
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
-
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
-----------------
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
----------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
48.21
31%
-45
- C4 -
-
3QLF
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
-----
M
S
P
E
A
F
L
Q
E
A
Q
V
M
K
K
I
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-----------------------------
A
K
F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
48.19
31%
28
- C4 -
-
3LW0
3
D:
[20-303]
---------------------
S
R
E
L
G
Q
G
S
F
G
M
V
YEGVAK
G
V
V
--
K
D
--
E
P
E
T
R
-
V
-
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
-
T
------
L
V
I
M
E
L
M
T
R
G
D
L
KSY
L
R
S
L
R
P
-----------------------------
P
---
P
S
L
S
K
M
----------
I
--
Q
M
AG------
E
I
A
--------
D
G
M
A
Y
L
N
--
A
N
K
--
F
V
H
R
D
L
A
A
R
N
C
M
V
A
E
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
---
K
G
-
L
-
L
PV
R
---
W
M
S
P
E
S
L
K
D
--
G
V
F
T
T
Y
S
------
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
------
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
G
G
LL
D
---
K
-
P
D
-------------
N
C
P
-----
D
----
M
L
------
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
--------
I
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
48.19
32%
-30
- C4 -
-
3AC4
2
LCK_HUMAN
A:
[27-276]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------
R
L
I
E
D
N
E
T
A
R
E
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
48.14
33%
-12
- C4 -
-
6SZJ
1
?
B:
[64-311]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
-----------------
E
--------
G
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
G
Q
K
S
RASIKH
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Blastp_CBE
48.14
34%
-40
- C4 -
-
5NG0
1
RIPK2_HUMAN
B:
[67-301]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
M
----------
S
A
P
E
--------
G
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
G
---RASIKH
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
CLIE
L
E
P
V
F
R
T
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
48.12
32%
-33
- C4 -
-
3AC1
3
LCK_HUMAN
A:
[27-276]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------
R
L
I
E
D
N
E
T
A
R
E
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
48.10
33%
-24
- C4 -
-
6FU5
1
RIPK2_HUMAN
A:
[63-311]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
----------------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
----SIKH--
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
48.09
33%
-25
- C4 -
-
5AR3
1
RIPK2_HUMAN
A:
[79-326]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
M
----------------------
G
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
------ASIKH-
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
48.03
33%
-13
- C4 -
-
5J79
1
RIPK2_HUMAN
B:
[79-326]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
M
-----------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
G
Q
--SIKH--
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
47.98
31%
-56
- C4 -
-
2QLQ
2
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
----------------
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
47.98
31%
-54
- C4 -
-
3QLF
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
------------
L
Q
E
A
Q
V
M
K
K
I
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
47.98
33%
-35
- C4 -
-
5AR4
1
RIPK2_HUMAN
A:
[79-326]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
------------------------------
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
-----ASIKH-
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
47.97
32%
-31
- C4 -
-
2ZM4
2
LCK_HUMAN
A:
[27-276]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------
R
L
I
E
D
N
E
T
A
R
E
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
47.97
33%
-18
- C4 -
-
6SZJ
1
?
A:
[64-311]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
----------------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
G
Q
--SIKH--
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
47.95
33%
-32
- C4 -
-
6UL8
1
?
A:
[59-306]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
C
K
W
-------------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
-----SIKH--
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
47.94
31%
-57
- C4 -
-
2HWP
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
C
-
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
-------------
F
L
Q
-
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
-
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
-------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
47.91
32%
-32
- C4 -
-
2ZYB
1
LCK_HUMAN
A:
[27-276]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------
R
L
I
E
D
N
E
T
A
R
E
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
47.73
31%
-65
- C4 -
-
3LOK
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
--
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
------------------
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
47.72
31%
-66
- C4 -
-
2QQ7
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
--
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
----------------
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
47.72
33%
-25
- C4 -
-
4XCU
1
A:
[69-292]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
RPPGSSEGP
L
--------------
S
F
--
P
---
V
L
V
S
------------
C
--
A
Y
--------
Q
V
A
--------
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
47.70
33%
-57
- C4 -
-
6NVG
1
A:
[69-292]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
RPPGSSEGP
L
--------------
S
F
--
P
---
V
L
V
S
------------
C
--
A
Y
--------
Q
V
A
--------
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
47.61
31%
-50
- C4 -
-
4FIC
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
-----------------
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
47.54
31%
-49
- C4 -
-
1SM2
1
ITK_HUMAN
A:
[12-249]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------------------PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
47.43
31%
-56
- C4 -
-
1SNU
1
ITK_HUMAN
A:
[12-249]
-----------------------
E
I
G
S
G
Q
F
G
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
R
E
G
A
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
-------------------------------------PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
47.38
31%
-57
- C4 -
-
5D10
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
----
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
G
---
T
M
S
P
E
A
----
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
---------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
47.30
32%
-34
- C4 -
-
3AD4
3
LCK_HUMAN
A:
[27-276]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------
R
L
I
E
D
N
E
T
A
R
E
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
47.26
33%
-25
- C4 -
-
6SZE
1
?
A:
[64-311]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
-----------------------------
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
-----SIKH--
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
47.16
33%
-62
- C4 -
-
6NVK
1
A:
[69-292]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
RPPGSSEGP
L
--------------
S
F
--
P
---
V
L
V
S
------------
C
--
A
Y
--------
Q
V
A
--------
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
47.03
33%
-10
- C4 -
-
5J7B
1
RIPK2_HUMAN
B:
[79-326]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
------------------
E
--------
G
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
G
Q
K
S
RASIKH
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
46.87
31%
-55
- C4 -
-
6HVE
1
?
B:
[24-275]
----------------------
V
K
L
G
Q
G
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
--------------
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
M
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
Blastp_CBE
46.84
34%
-25
- C4 -
-
5NG0
1
RIPK2_HUMAN
A:
[67-301]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
M
-----------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
----SIKH--
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
CLIE
L
E
P
V
F
R
T
F
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
46.80
31%
-58
- C4 -
-
3EN6
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
--
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
----------------
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
---
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
----------------------------------
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
114
Blastp_CBE
46.75
32%
-30
- C4 -
-
3AC8
1
LCK_HUMAN
A:
[27-276]
------------------------
L
G
A
G
Q
F
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------
R
L
I
E
D
N
E
T
A
R
E
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
46.53
33%
-14
- C4 -
-
5AM7
1
FGFR1_HUMAN
A:
[73-299]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
M
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGP----------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Blastp_CBE
46.52
33%
-33
- C4 -
-
5W5J
1
RIPK2_HUMAN
B:
[62-310]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP--
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
--------------------------------
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
-----IKH---
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
46.48
32%
10
- C4 -
-
5HHW
2
?
A:
[25-280]
-----------------------
E
L
G
Q
G
S
F
G
M
V
YEGNAR
D
I
I
--
K
G
--
E
A
E
T
R
-
V
-
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
-
T
------
L
V
V
M
E
L
M
A
H
G
D
L
---
K
S
Y
L
R
S
L
---------
R
--------------
P
E
--
A
---
E
N
N
P
G
R
PPPTLQEMIQ
M
--
A
A
--------
E
I
A
--------
D
G
M
A
Y
L
N
--
A
K
K
--
F
V
H
R
N
L
A
A
R
N
C
M
V
A
H
D
F
T
V
K
I
G
D
F
G
M
T
-------------
R
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
-
L
-
L
PV
R
---
W
M
A
P
E
S
L
K
D
--
G
V
F
T
T
S
S
------
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
------
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
G
G
YL
D
---
Q
-
P
D
-------------
N
C
P
-----
E
----
R
V
------
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
46.46
33%
-46
- C4 -
-
5NG2
1
RIPK2_HUMAN
B:
[67-287]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
N
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
M
-----------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
-
Q
K
S
RASIKH
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
46.40
33%
-16
- C4 -
-
6FU5
1
RIPK2_HUMAN
B:
[63-311]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
------------------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
G
Q
K
S
RASIKH
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
----
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
46.19
31%
-53
- C4 -
-
4LGH
1
SRC_CHICK
B:
[15-266]
----------------------
V
K
L
G
Q
-
C
F
G
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
K
P
-------------
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
G
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
F
G
L
------------------------------
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
46.09
31%
-33
- C4 -
-
1QPD
1
?
A:
[21-270]
------------------------
L
G
A
G
Q
A
G
E
V
------
W
M
G
--
Y
Y
--
N
G
H
T
K
-
V
-
A
V
K
S
L
K
Q
G
S
M
S
---
P
D
A
F
L
A
E
A
N
L
M
K
Q
L
-
Q
H
Q
R
L
V
R
L
Y
A
V
V
T
Q
E
P
I
-
Y
-------
I
I
T
E
Y
M
E
N
G
S
L
---
V
D
F
L
K
T
P
---------
S
--------------
G
I
--
K
---
L
T
I
N
K
L
----------
L
--
D
M
AA------
Q
I
A
--------
E
G
M
A
F
I
E
--
E
R
N
--
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
D
T
L
S
C
K
I
A
D
F
G
L
A
--------------
R
L
I
E
D
A
E
T
A
R
E
G
A
K
F
P
-
I
--
K
---
W
T
A
P
E
A
I
N
--
Y
G
T
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
I
V
T
-
H
G
R
I
-
P
------
Y
P
-
G
M
T
N
P
E
V
I
Q
N
L
E
R
G
--
Y
RMV
R
-
P
D
-------------
N
C
P
-----
E
----
E
L
------
Y
Q
L
M
R
L
C
W
K
E
R
P
E
D
R
P
T
F
D
Y
----
L
R
S
V
L
E
D
F
F
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
46.02
31%
-47
- C4 -
-
3EN7
1
SRC_CHICK
A:
[24-275]
----------------------
V
K
L
G
Q
G
---
E
V
------
W
M
G
--
T
W
--
N
--
T
R
-
V
-
A
I
K
T
L
K
P
----------
F
L
Q
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
45.79
33%
-19
- C4 -
-
4QRC
1
A:
[87-320]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PPGPDLSP------
D
G
--
P
---
R
S
S
E
G
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
E
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
45.63
32%
-16
- C4 -
-
4M69
1
RIPK3_MOUSE
A:
[31-311]
---------------------------
G
G
F
G
V
V
------
F
R
A
--
H
H
--
R
T
W
N
H
-
D
-
V
A
V
K
-------
I
V
N
S
K
K
I
S
W
E
V
K
A
M
V
N
L
-
R
N
E
N
V
L
L
L
L
G
V
T
-
E
D
L
Q
-
W
DFVSGQ
A
L
V
T
R
F
M
E
N
G
S
L
---
A
G
L
L
Q
P
E
---------
C
--------------
P
R
--
P
---
W
P
L
L
C
R
----------
L
--
L
Q
--------
E
V
V
--------
L
G
M
C
Y
L
H
--
S
L
D
PP
L
L
H
R
D
L
K
P
S
N
I
L
L
D
P
E
L
H
A
K
L
A
D
F
G
L
S
T
F
Q
G
G
---------------------
G
G
-
T
-
L
--
A
---
Y
L
D
P
E
L
L
F
K
V
N
L
K
A
S
K
A
S
------
D
V
Y
S
F
G
I
L
V
W
A
V
L
A
-
G
-
R
E
-
A
ELVDKL
I
R
E
T
V
C
D
R
Q
----------
S
---
R
-
P
P
L
T
E
---
L
P
P
----
G
S
P
ETPGL
E
----
K
L
------
K
E
L
M
I
H
C
W
G
S
Q
S
E
N
R
P
S
F
Q
D
----
C
E
P
K
T
N
E
V
Y
-
N
L
V
K
D
K
V
D
A
A
V
S
E
V
K
H
Y
L
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
45.44
33%
-21
- C4 -
-
4F63
3
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
45.41
33%
-29
- C4 -
-
4V05
3
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP-------------
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-----------------
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
45.38
33%
-18
- C4 -
-
4ZSA
1
FGFR1_HUMAN
A:
[71-297]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
45.37
31%
-58
- C4 -
-
2HWP
1
SRC_CHICK
B:
[24-275]
----------------------
V
K
L
G
Q
G
---
E
V
------
W
M
G
--
T
W
--
N
G
T
T
R
-
V
-
A
I
K
T
L
-----------------
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
T
E
Y
M
S
K
G
C
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
---------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
45.38
33%
-30
- C4 -
-
5NG2
1
RIPK2_HUMAN
A:
[67-287]
-------------------------------------------------------------------------
V
L
R
E
A
E
I
L
H
K
A
-
R
F
S
Y
I
L
P
I
L
G
I
C
N
E
P
E
F
-
L
------
G
I
V
T
E
Y
M
P
N
G
S
L
---
N
E
L
L
H
R
K
---------
T
--------------
E
Y
--
P
DVA
W
P
L
R
F
R
----------
I
--
L
H
--------
E
I
A
--------
L
G
V
N
Y
L
H
--
N
M
T
PP
L
L
H
H
N
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
K
I
A
D
F
G
L
S
K
W
R
M
M
----------------------
G
-
T
-
I
--
I
---
Y
M
P
P
E
-----
N
Y
E
P
----SIKH--
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
-
R
-
K
Q
-
P
------
F
E
D
V
T
N
P
L
Q
I
M
Y
S
V
S
Q
G
--
H
---
R
-
P
V
I
N
E
-----
E
----
S
L
P
-----
Y
----
D
I
PHRARM
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
45.37
33%
-32
- C4 -
-
6IUP
2
?
A:
[86-319]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
P-----------------
P
---
R
S
S
E
G
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
E
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
552
Blastp_CBE
45.35
33%
-18
- C4 -
-
3C4F
1
B:
[65-291]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
553
Blastp_CBE
45.34
33%
-24
- C4 -
-
3C4F
1
FGFR1_HUMAN
A:
[65-291]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
527
Blastp_CBE
45.31
33%
-19
- C4 -
-
5A4C
6
FGFR1_HUMAN
A:
[70-296]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGLEYSYNPSHNP
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
45.27
33%
-15
- C4 -
-
5AM7
1
B:
[73-299]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
M
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGP----------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
-----
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
45.26
33%
-6
- C4 -
-
6JPJ
1
A:
[75-310]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PPGPDLSP------
D
G
--
P
---
R
S
S
E
G
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
E
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
S
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
45.20
33%
-23
- C4 -
-
4F64
3
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
45.19
33%
3
- C4 -
-
4UWC
9
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGLEYSYPSHNP-
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
45.17
33%
-46
- C4 -
-
4WUN
1
B:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP----------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
45.14
31%
-45
- C4 -
-
4LGH
1
SRC_CHICK
A:
[15-266]
----------------------
V
K
L
G
Q
G
--
G
E
V
------
W
M
G
--
T
W
--
N
G
-
T
R
-
V
-
A
I
K
T
L
---------------
E
A
Q
V
M
K
K
L
-
R
H
E
K
L
V
Q
L
Y
A
V
V
S
E
E
P
I
-
Y
-------
I
V
G
E
Y
M
S
K
G
S
L
---
L
D
F
L
K
G
E
---------
M
--------------
G
K
--
Y
---
L
R
L
P
Q
L
----------
V
--
D
M
AA------
Q
I
A
--------
S
G
M
A
Y
V
E
--
R
M
N
--
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
E
N
L
V
C
K
V
A
D
--------------------------------F
P
-
I
--
K
---
W
T
A
P
E
--
A
A
L
Y
G
R
F
T
I
K
S
------
D
V
W
S
F
G
I
L
L
T
E
L
T
T
K
G
-
R
V
-
P
------
Y
P
G
M
V
N
R
E
V
L
D
Q
V
E
R
G
Y
--
R
---
M
-
P
C
P
P
E
-----------
C
P
-----
E
----
S
L
------
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
----
L
Q
A
F
L
E
D
Y
F
T
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
45.10
33%
-21
- C4 -
-
5O49
1
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
45.07
33%
-21
- C4 -
-
5Z0S
1
FGFR1_HUMAN
A:
[71-297]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
44.96
33%
-31
- C4 -
-
4NKS
1
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP----------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
44.89
33%
-18
- C4 -
-
5Z0S
1
B:
[71-297]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
44.83
33%
-21
- C4 -
-
4ZSA
1
B:
[71-297]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
-------------------
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
44.71
33%
-23
- C4 -
-
4V01
6
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
P-----------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
---------------------
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
44.65
33%
-32
- C4 -
-
6NVI
1
A:
[69-292]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
RPPSEGP--
L
--------------
S
F
--
P
---
V
L
V
S
------------
C
--
A
Y
--------
Q
V
A
--------
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
G
V
---------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
44.63
33%
-14
- C4 -
-
6ITJ
1
?
A:
[71-297]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
44.58
33%
-25
- C4 -
-
4WUN
1
FGFR1_HUMAN
A:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPLEYSYNPSHNP-
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
44.55
33%
-14
- C4 -
-
4NKA
2
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP-------------
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-------------------
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
44.47
33%
12
- C4 -
-
4UWB
3
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGLEYSYHNP---
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
---
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
44.40
33%
-27
- C4 -
-
6C1C
1
B:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
P-----------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
44.24
31%
-53
- C4 -
-
4MF0
2
ITK_HUMAN
A:
[14-251]
-----------------------
E
I
G
S
G
---
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
----
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
F
G
M
T
-----------------------------------PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
44.20
33%
-53
- C4 -
-
5NUD
1
FGFR4_HUMAN
A:
[71-307]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
P--------------------------
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
------------------------------
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
S
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
547
Blastp_CBE
44.19
33%
-20
- C4 -
-
3RHX
5
FGFR1_HUMAN
A:
[69-295]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
44.12
33%
2
- C4 -
-
4UWC
9
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGLEYSYHNP---
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
44.08
33%
-20
- C4 -
-
4V04
5
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP-------------
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
---------------------
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
44.04
33%
-1
- C4 -
-
5O4A
2
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPG-----------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
526
Blastp_CBE
44.00
33%
-16
- C4 -
-
5A4C
6
B:
[70-296]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP-------------
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------------------
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
44.00
33%
-22
- C4 -
-
4V01
6
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP----------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
---------------------
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
43.93
33%
7
- C4 -
-
4RWK
1
FGFR1_HUMAN
A:
[80-306]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
M
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGLEYSYNPSHNP
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
546
Blastp_CBE
43.87
33%
-22
- C4 -
-
3RHX
2
B:
[69-295]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
------------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
534
Blastp_CBE
43.82
33%
-36
- C4 -
-
6C1B
1
B:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
------------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
43.80
33%
-21
- C4 -
-
4NKA
3
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
43.64
33%
-28
- C4 -
-
4RWK
1
B:
[80-306]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
M
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
------------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------------------
I
D
Y
Y
K
K
T
--
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
43.42
33%
-23
- C4 -
-
4F64
3
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
------------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------
D
Y
Y
K
K
---
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
508
Blastp_CBE
43.34
33%
-23
- C4 -
-
4NKS
1
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
------------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------
D
Y
Y
K
K
---
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
43.32
33%
-19
- C4 -
-
4NK9
5
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP-------------
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
43.06
33%
-22
- C4 -
-
4F63
3
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
------------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------
D
Y
Y
K
K
---
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
43.05
33%
-14
- C4 -
-
4F65
4
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
P-----------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
--------------------
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
42.94
33%
-26
- C4 -
-
5UR1
1
B:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
P-----------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
42.90
33%
-14
- C4 -
-
6C1C
1
FGFR1_HUMAN
A:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPSYNPSHNP----
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
549
Blastp_CBE
42.85
33%
-3
- C4 -
-
5ZV2
1
FGFR1_HUMAN
A:
[69-295]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
P--------------
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
--
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
42.82
33%
-20
- C4 -
-
6C1B
1
FGFR1_HUMAN
A:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
P-------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
42.74
33%
-7
- C4 -
-
4NK9
2
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PP----------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
42.72
33%
16
- C4 -
-
4UWB
4
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGLEYSPSHNP--
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
Blastp_CBE
42.65
33%
-16
- C4 -
-
6MZW
1
FGFR1_HUMAN
A:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGLEYSYNPSP--
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
42.62
33%
-52
- C4 -
-
4TYJ
2
A:
[75-311]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
P--------------------------
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------------------
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
S
E
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
42.61
33%
-0
- C4 -
-
5O4A
1
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGLEYSY------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
543
Blastp_CBE
42.56
33%
-25
- C4 -
-
5UQ0
1
FGFR1_HUMAN
A:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
P--------------
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
--
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
530
Blastp_CBE
42.56
33%
-24
- C4 -
-
6C1O
1
B:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
P-----------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
42.40
33%
-30
- C4 -
-
6C18
1
B:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
------------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-----------------------------------PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
548
Blastp_CBE
42.33
33%
-15
- C4 -
-
5ZV2
1
B:
[69-295]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
P-------------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------
D
Y
Y
K
K
T
----
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
42.30
33%
-26
- C4 -
-
6C19
1
B:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
---------------
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
42.18
33%
-3
- C4 -
-
6C18
1
FGFR1_HUMAN
A:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGSYNPSHNP---
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
550
Blastp_CBE
42.15
33%
-15
- C4 -
-
6MZW
1
B:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
P-----------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-----------------------------------PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
41.99
33%
-3
- C4 -
-
6MZQ
1
FGFR1_HUMAN
A:
[74-301]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGLEYSYNPS---
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
41.98
33%
2
- C4 -
-
5O49
1
B:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPG------------
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
H
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
41.83
33%
-25
- C4 -
-
6IUO
1
?
A:
[86-319]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PP------------------------
G
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
E
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
41.81
33%
-2
- C4 -
-
4V04
6
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGLEYSPSHNP--
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
---------------------
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
41.77
33%
20
- C4 -
-
6ITJ
1
?
B:
[71-297]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPGLEYSYP-----
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------------------
I
D
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
41.74
31%
-45
- C4 -
-
4MF0
2
B:
[14-251]
-----------------------
E
I
G
S
G
---
L
V
------
H
L
G
--
Y
W
--
L
N
K
D
K
-
V
-
A
I
K
T
I
----
M
---
S
E
E
D
F
I
E
E
A
E
V
M
M
K
L
-
S
H
P
K
L
V
Q
L
Y
G
V
C
L
E
Q
A
P
-
I
------
C
L
V
F
E
F
M
E
H
G
C
L
---
S
D
Y
L
R
T
Q
RG-------
L
--------------
F
A
--
A
---
E
T
L
L
G
-----------
M
--
C
L
--------
D
V
C
--------
E
G
M
A
Y
L
E
--
E
A
C
--
V
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
Q
V
I
K
V
S
D
--------------------------------------
F
PVK
W
A
S
P
E
V
F
S
--
F
S
R
Y
S
S
K
S
------
D
V
W
S
F
G
V
L
M
W
E
V
F
S
E
G
-
K
I
-
P
------
Y
E
N
------------
R
S
--
N
---
S
-
E
V
V
E
D
---
I
S
T
GFRL
Y
K
P
-----
R
LAST
H
V
------
Y
Q
I
M
N
H
C
W
K
E
R
P
E
D
R
P
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
41.66
33%
-31
- C4 -
-
6MZQ
1
B:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
--------------------------------
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
----------------------------------PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
41.66
33%
-28
- C4 -
-
4TYI
1
A:
[75-308]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PP-------------------------
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------
R
G
----------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
41.53
33%
-30
- C4 -
-
5NUD
1
B:
[71-304]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PP-------------------------
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
--------------------------------
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
41.25
33%
-23
- C4 -
-
5UQ0
1
B:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
------------------
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
--
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
41.19
33%
-21
- C4 -
-
4QQC
1
A:
[87-320]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PP------------------------
G
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
E
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
41.10
33%
-18
- C4 -
-
4R6V
1
A:
[87-320]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
L
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PP------------------------
G
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
--------------------------------PV
K
---
W
M
A
P
E
A
L
F
D
E
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
40.96
33%
19
- C4 -
-
4F65
5
FGFR1_HUMAN
A:
[72-298]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPP-----------
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
-----------------------
Y
Y
K
K
T
T
N
G
-
R
-
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
40.89
33%
-22
- C4 -
-
4QQ5
1
A:
[87-320]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
L
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PP------------------------
G
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
E
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
40.39
33%
-15
- C4 -
-
5XFF
1
A:
[75-308]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
L
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PPGP-----------------------
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
40.21
33%
-12
- C4 -
-
5JKG
1
A:
[75-308]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
V
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PPGP-----------------------
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
40.00
33%
5
- C4 -
-
6C19
1
FGFR1_HUMAN
A:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPEYSYNPS-----
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
39.94
33%
-15
- C4 -
-
5XFJ
1
A:
[75-308]
-------------------------------------------------------------------------
L
V
S
E
M
E
V
M
K
L
I
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
-
L
------
Y
V
I
M
E
C
A
A
K
G
N
L
---
R
E
F
L
R
A
R
---------
R
PPGP-----------------------
P
----------
L
--
S
F
--------
P
V
L
VSCAYQVA
R
G
M
Q
Y
L
E
--
S
R
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
V
Y
--
T
H
Q
S
------
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
-
I
P
V
E
E
L
F
S
L
L
R
E
G
--
H
---
R
----
M
D
---
R
P
P
----
H
C
P
-----
P
----
E
L
------
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
----
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
531
Blastp_CBE
39.87
33%
9
- C4 -
-
6C1O
1
FGFR1_HUMAN
A:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPYNPSHNP-----
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
L
--------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
39.82
33%
23
- C4 -
-
5UR1
1
FGFR1_HUMAN
A:
[74-300]
-------------------------------------------------------------------------
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
-
L
------
Y
V
I
V
E
Y
A
S
K
G
N
L
---
R
E
Y
L
Q
A
R
---------
R
PPYNPSHNP-----
E
E
--
Q
---
L
S
S
K
D
L
----------
V
SC
A
Y
--------
Q
V
A
--------
R
G
M
E
Y
L
A
--
S
K
K
--
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
D
N
V
M
K
I
A
D
F
G
---------------------------------
L
PV
K
---
W
M
A
P
E
A
L
F
D
R
I
Y
--
T
H
Q
S
------
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
G
-
G
S
-
P
------
Y
P
G
V
P
V
E
-
E
L
F
K
L
L
K
E
G
--
H
---
R
-
M
D
K
------
P
S
----
N
C
T
-----
N
----
E
L
------
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------