@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : RIPK2_HUMAN: (2020-09-20 )
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
Atome Classification :
(168 SA)
.........10........20........30........40..-....---..50........60...-.....70........80....-....90----.........100.......110-.......120.......130....-.-..140........150.......160........170.......180.......190.......200....-...210.......220.......230...-....240....-...250....---...260-.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
N
G
E
A
I
C
S
ALPTIP
Y
H
K
L
A
D
L
R
Y
L
SRGASGTVSSARHA
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
IHTPLL
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
LGIC-NE
P
E
F
-----
L
G
I
V
T
E
YMPNG
S
L
N
E
L
L
H
RKTE-YPDV
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H-N-MT
P
-
P
L
L
H
HDLKT
Q
N
I
L
LDNEF
H
V
-
K
I
ADFGLS
K
W
R
M
M
S
L
SQSRSSKSAPEG
G
T
I
I
Y
MPPENYEPGQK
S
R
A
-
S
I
K
HDI
Y
S
Y
A
V
I
T
W
E
V
L
SRKQ
P
F
E
DVT
N
P
-
L
Q
I
M
YSVSQGH-RPVINEESLP---YDI
P
H
R
-
A
R
M
I
S
L
I
E
SGWAQNPDE
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
V
S
S
A
I
H
LCDK
K
K
M
E
L
S
L
NIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQD
N
D
F
L
S
R
KAQ
D
C
Y
F
M
K
L
HHCPGNHSWDSTISGSQ
R
A
A
FCDHKTTPC
S
S
A
IIN
P
L
STAG
N
S
E
RLQ
P
G
I
A
Q
Q
W
I
Q
S
K
R
E
D
I
V
N
Q
M
T
E
A
C
L
N
Q
S
L
D
A
L
L
S
R
D
L
I
MKEDYELVSTKPT
R
T
S
K
V
R
Q
L
L
DTTDI
Q
G
E
E
F
A
K
V
I
V
Q
K
L
KDNKQMGLQPYP
E
I
L
V
V
SRSPSL
N
L
LQNKSM
35
Blastp_CBE
96.32
100%
-135
- C3 -
-
5AR7
1
RIPK2_HUMAN
B:
[22-326]
-----
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
-----
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
---------------------
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
--
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
96.23
100%
-140
- C3 -
-
6RN8
1
RIPK2_HUMAN
B:
[6-311]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
-
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
--
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
-------------
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
95.41
100%
-134
- C3 -
-
6ES0
1
RIPK2_HUMAN
B:
[5-315]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
--------
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
----------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
95.30
100%
-137
- C3 -
-
6RNA
1
RIPK2_HUMAN
B:
[5-311]
---
E
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
---
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
-------
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
-------------
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
95.01
100%
-115
- C3 -
-
6S1F
1
?
A:
[5-316]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
----------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
------
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
94.99
100%
-129
- C3 -
-
5J79
1
RIPK2_HUMAN
A:
[18-326]
-
N
G
E
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
----------
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
----------
S
A
P
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
94.96
100%
-128
- C3 -
-
6S1F
1
?
C:
[5-315]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
----------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
94.83
100%
-133
- C3 -
-
6HMX
1
RIPK2_HUMAN
B:
[6-311]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
----------
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
--------------
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
94.78
100%
-136
- C3 -
-
5J7B
1
RIPK2_HUMAN
B:
[20-326]
---
E
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
--------
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
------------------
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.68
100%
-138
- C3 -
-
6ES0
1
RIPK2_HUMAN
A:
[5-316]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
-----------------
G
T
I
I
Y
M
P
P
E
N
Y
-------
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
94.54
100%
-138
- C3 -
-
6HMX
1
RIPK2_HUMAN
A:
[6-311]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
-----
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
---------------
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
94.41
100%
-131
- C3 -
-
5AR5
1
RIPK2_HUMAN
A:
[20-326]
---
E
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
----
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
-------------
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
94.30
100%
-140
- C3 -
-
5AR4
1
RIPK2_HUMAN
B:
[22-326]
-----
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
------
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
--------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
94.18
100%
-129
- C3 -
-
6S1F
1
?
D:
[5-316]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
-----------------
G
T
I
I
Y
M
P
P
E
N
Y
-------
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
94.05
100%
-141
- C3 -
-
6SZE
1
?
B:
[6-311]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
---
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
------
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
---------------
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
93.89
100%
-143
- C3 -
-
5J7B
1
RIPK2_HUMAN
A:
[21-326]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
-----
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
--------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
----
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
93.82
100%
-141
- C3 -
-
5AR2
-
RIPK2_HUMAN
A:
[20-326]
---
E
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
----
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
------
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
--------------
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
93.73
100%
-137
- C3 -
-
5W5O
1
RIPK2_HUMAN
B:
[4-309]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
---------
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
---------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
--------
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
93.71
100%
-140
- C3 -
-
6SZJ
1
?
A:
[6-311]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
---
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
--------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
-----
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
93.66
100%
-135
- C3 -
-
5AR3
1
RIPK2_HUMAN
B:
[22-326]
-----
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
--------
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
----------------
T
I
I
Y
M
P
P
E
N
Y
E
P
-----
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
93.44
100%
-133
- C3 -
-
6FU5
1
RIPK2_HUMAN
B:
[5-316]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
----
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
----------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
93.40
100%
-135
- C3 -
-
5AR5
1
RIPK2_HUMAN
B:
[20-326]
---
E
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
----
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
-----------------
T
I
I
Y
M
P
P
E
N
Y
E
--------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
93.32
100%
-136
- C3 -
-
5J79
1
RIPK2_HUMAN
B:
[21-326]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
----------
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
---------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
-----
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
60
Blastp_CBE
93.27
99%
-137
- C3 -
-
5NG2
1
RIPK2_HUMAN
B:
[9-302]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
N
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
---------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
HHSearch
93.16
100%
-123
- C3 -
-
5NG0
1
RIPK2_HUMAN
B:
[9-302]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
----------
S
A
P
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
---
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
F
R
T
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
93.12
100%
-128
- C3 -
-
6S1F
1
?
B:
[5-315]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
-----
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
M
S
--------------
T
I
I
Y
M
P
P
E
------
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
Blastp_CBE
93.02
99%
-123
- C3 -
-
5NG0
1
RIPK2_HUMAN
B:
[9-303]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
----------
S
A
P
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
---
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
F
R
T
F
E
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
92.86
100%
-133
- C3 -
-
6RN8
1
RIPK2_HUMAN
A:
[6-311]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
---
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
---------------
G
T
I
I
Y
M
P
P
E
N
Y
E
--------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
92.82
100%
-133
- C3 -
-
6FU5
1
RIPK2_HUMAN
A:
[5-315]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
---
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
--------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
92.79
100%
-130
- C3 -
-
6SZJ
1
?
B:
[6-311]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
------
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
-----------------
E
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
Blastp_CBE
92.57
99%
-134
- C3 -
-
6UL8
1
?
B:
[1-306]
----
A
I
S
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
------
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
C
K
W
-----------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
92.57
100%
-144
- C3 -
-
5AR4
1
RIPK2_HUMAN
A:
[21-326]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
-----
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
---------------------
T
I
I
Y
M
P
P
E
N
Y
E
------
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
92.53
100%
-138
- C3 -
-
6RNA
1
RIPK2_HUMAN
A:
[6-311]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
-
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
------
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
--------------
G
G
T
I
I
Y
M
P
P
E
N
Y
---------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
92.35
100%
-135
- C3 -
-
5AR3
1
RIPK2_HUMAN
A:
[22-326]
-----
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
-----
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
--------------
G
G
T
I
I
Y
M
P
P
E
N
Y
-------
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
Blastp_CBE
92.21
99%
-129
- C3 -
-
4C8B
1
RIPK2_HUMAN
B:
[26-333]
--------
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
-----
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
----------------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
91.93
100%
-134
- C3 -
-
5AR7
1
RIPK2_HUMAN
A:
[22-326]
-----
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
-----
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
----------------
T
I
I
Y
M
P
P
E
N
Y
E
------
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
91.84
100%
-136
- C3 -
-
6SZE
1
?
A:
[6-311]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
-----
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
--------------------
T
I
I
Y
M
P
P
E
N
Y
E
--------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
91.81
100%
-139
- C3 -
-
5AR8
1
RIPK2_HUMAN
B:
[24-326]
-------
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
----------
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
-------------------
G
G
T
I
I
Y
M
P
P
E
N
Y
E
P
G
Q
K
S
R
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
91.77
99%
-134
- C3 -
-
4C8B
2
RIPK2_HUMAN
A:
[25-333]
-------
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
----------------------
G
T
I
I
Y
M
P
P
E
N
Y
---------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
T
K
L
Q
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
304
HHSearch
91.40
100%
-138
- C3 -
-
6RNA
1
RIPK2_HUMAN
A:
[6-307]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
-
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
------
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
--------------
G
G
T
I
I
Y
M
P
P
E
N
Y
---------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
58
Blastp_CBE
91.39
99%
-139
- C3 -
-
6UL8
1
?
A:
[1-306]
----
A
I
S
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
---
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
C
K
W
-----------------
G
T
I
I
Y
M
P
P
E
N
Y
E
--------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
91.26
99%
-136
- C3 -
-
5NG0
1
RIPK2_HUMAN
A:
[10-304]
-----
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
---------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
F
R
T
F
E
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
Blastp_CBE
91.12
99%
-141
- C3 -
-
5NG2
1
RIPK2_HUMAN
A:
[9-302]
----
A
I
C
S
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
I
H
T
P
L
L
D
S
E
R
K
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
N
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
G
L
S
K
W
R
M
M
--------------
G
T
I
I
Y
M
P
P
E
N
Y
E
P
-------
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Blastp_CBE
89.43
100%
-148
- C3 -
-
5W5J
1
RIPK2_HUMAN
B:
[9-310]
---------
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
-
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
H
-----------
D
V
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
E
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
--
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
-----------------------
T
I
I
Y
M
P
P
E
N
Y
E
---------
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
87.92
100%
-148
- C3 -
-
5W5J
1
RIPK2_HUMAN
A:
[8-309]
--------
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
---------------------
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
E
P
-
F
-----
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
-----------------------
T
I
I
Y
M
P
P
E
N
Y
E
P
--------
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
87.09
100%
-150
- C3 -
-
5AR8
1
RIPK2_HUMAN
A:
[25-326]
--------
A
L
P
T
I
P
Y
H
K
L
A
D
L
R
Y
L
S
R
G
A
S
G
T
V
S
S
A
R
H
A
D
W
R
V
Q
-
V
A
V
K
---
H
L
--------------
L
-
R
E
A
E
I
L
H
K
A
R
F
S
Y
I
L
P
I
L
G
I
C
-
N
---------
L
G
I
V
T
E
Y
M
P
N
G
S
L
N
E
L
L
H
R
K
T
E
-
Y
P
D
V
A
W
P
L
R
F
R
I
L
H
E
I
A
L
G
V
N
Y
L
H
-
N
-
M
T
P
-
P
L
L
H
H
D
L
K
T
Q
N
I
L
L
D
N
E
F
H
V
-
K
I
A
D
F
----------------------
G
T
I
I
Y
M
P
P
E
N
Y
-------
A
-
S
I
K
H
D
I
Y
S
Y
A
V
I
T
W
E
V
L
S
R
K
Q
P
F
E
D
V
T
N
P
-
L
Q
I
M
Y
S
V
S
Q
G
H
-
R
P
V
I
N
E
E
S
L
P
---
Y
D
I
P
H
R
-
A
R
M
I
S
L
I
E
S
G
W
A
Q
N
P
D
E
R
P
S
F
L
K
C
L
I
E
L
E
P
V
L
R
T
F
E
E
I
T
F
L
E
A
V
I
Q
L
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
HHSearch
71.33
41%
-138
- C3 -
-
5WNL
1
RIPK4_MOUSE
A:
[13-288]
--------
L
L
R
T
F
D
A
G
E
F
A
G
W
E
K
V
G
S
G
G
F
G
Q
V
Y
K
V
R
H
V
H
W
K
T
W
-
L
A
I
K
---
C
S
P
----
V
D
D
R
E
R
M
E
L
L
-
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
--
P
-----
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
L
L
A
S
E
P
-----
L
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
-
C
-
M
S
P
-
P
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
C
----------------
F
G
T
I
A
Y
L
P
P
E
R
I
R
E
K
-
S
R
L
F
-
D
T
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
A
D
E
K
N
I
-
L
H
I
M
M
K
V
V
K
G
H
-
R
P
E
L
P
P
I
-
C
R
---
P
R
P
R
A
C
-
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
I
T
S
E
T
E
D
L
C
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
309
HHSearch
70.68
41%
-135
- C3 -
-
5WNJ
1
RIPK4_MOUSE
A:
[13-288]
--------
L
L
R
T
F
D
A
G
E
F
A
G
W
E
K
V
G
S
--
F
G
Q
V
Y
K
V
R
H
V
H
W
K
T
W
-
L
A
I
K
---
C
S
P
S
L
H
-
V
D
D
R
E
R
M
E
L
L
-
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
--
P
-----
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
L
L
A
S
E
P
-----
L
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
-
C
-
M
S
P
-
P
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
C
----------------
F
G
T
I
A
Y
L
P
P
E
R
I
R
E
K
S
-
R
L
F
-
D
T
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
A
D
E
K
N
I
-
L
H
I
M
M
K
V
V
K
G
H
-
R
P
E
L
P
P
I
-
C
R
---
P
R
P
R
A
C
-
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
I
T
S
E
T
E
D
L
C
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
310
HHSearch
69.59
41%
-129
- C3 -
-
5WNI
1
RIPK4_MOUSE
A:
[13-288]
--------
L
L
R
T
F
D
A
G
E
F
A
G
W
E
K
V
G
S
----
Q
V
Y
K
V
R
H
V
H
W
K
T
W
-
L
A
I
K
---
C
S
P
S
L
H
-
V
D
D
R
E
R
M
E
L
L
-
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
--
P
-----
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
L
L
A
S
E
P
-----
L
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
-
C
-
M
S
P
-
P
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
C
N
---------------
F
G
T
I
A
Y
L
P
P
E
R
I
R
E
K
S
-
R
L
F
-
D
T
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
A
D
E
K
N
I
-
L
H
I
M
M
K
V
V
K
G
H
-
R
P
E
L
P
P
I
C
-
R
---
P
R
P
R
A
C
-
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
T
F
Q
E
I
T
S
E
T
E
D
L
C
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
60.57
38%
-11
- C3 -
-
5WNM
1
RIPK4_MOUSE
A:
[10-289]
-----
A
L
G
L
L
R
T
F
D
A
G
E
F
A
G
W
E
K
V
G
S
--
F
G
Q
V
Y
K
V
R
H
V
H
W
K
T
W
-
L
A
I
K
CSP
S
L
H
V
D
----
D
R
E
R
M
E
L
L
-
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
P
-------
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
L
L
A
S
E
P
-----
L
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
-
C
-
M
S
P
-
P
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
-----------------
F
G
T
I
A
Y
L
P
P
E
R
I
R
--
E
K
S
R
L
F
D
T
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
A
D
E
K
N
I
-
L
H
I
M
M
K
V
V
K
G
H
-
R
P
E
L
P
P
I
C
R
P
---
R
--
P
R
A
C
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
--------------
T
F
Q
E
I
T
----------------
S
E
T
E
D
L
C
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
59.99
38%
-15
- C3 -
-
5WNJ
1
RIPK4_MOUSE
A:
[10-289]
-----
A
L
G
L
L
R
T
F
D
A
G
E
F
A
G
W
E
K
V
G
S
--
F
G
Q
V
Y
K
V
R
H
V
H
W
K
T
W
-
L
A
I
K
CSP
S
L
H
V
D
----
D
R
E
R
M
E
L
L
-
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
P
-------
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
L
L
A
S
E
P
-----
L
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
-
C
-
M
S
P
-
P
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
C
----------------
F
G
T
I
A
Y
L
P
P
E
R
I
R
--
E
K
S
R
L
F
D
T
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
A
D
E
K
N
I
-
L
H
I
M
M
K
V
V
K
G
H
-
R
P
E
L
P
P
I
C
R
P
---
R
--
P
R
A
C
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
--------------
T
F
Q
E
I
T
----------------
S
E
T
E
D
L
C
E
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
139
Blastp_CBE
59.89
31%
-40
- C3 -
-
5JGA
1
M3K7_HUMAN
A:
[3-266]
---------
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
---
W
R
A
K
D
V
A
I
K
---
Q
I
E
S
-----
E
S
E
R
K
A
F
I
-
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
P
-------
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
G
A
E
P
-
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
-
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
T
A
-------------------
G
S
A
A
W
M
A
P
E
V
F
E
---
G
S
N
Y
-
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
V
H
N
G
T
-
R
P
P
L
I
-
K
N
L
P
---
K
P
I
E
-------
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
59.51
38%
-13
- C3 -
-
5WNL
1
RIPK4_MOUSE
A:
[10-288]
-----
A
L
G
L
L
R
T
F
D
A
G
E
F
A
G
W
E
K
V
G
S
G
G
F
G
Q
V
Y
K
V
R
H
V
H
W
K
T
W
-
L
A
I
K
CSP---
V
D
----
D
R
E
R
M
E
L
L
-
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
P
-------
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
L
L
A
S
E
P
-----
L
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
-
C
-
M
S
P
-
P
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
C
----------------
F
G
T
I
A
Y
L
P
P
E
R
I
R
--
E
K
S
R
L
F
D
T
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
A
D
E
K
N
I
-
L
H
I
M
M
K
V
V
K
G
H
-
R
P
E
L
P
P
I
C
R
P
---
R
--
P
R
A
C
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
--------------
T
F
Q
E
I
T
----------------
S
E
T
E
D
L
C
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
59.09
31%
-40
- C3 -
-
5GJD
1
M3K7_HUMAN
A:
[3-270]
---------
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
---
W
R
A
K
D
V
A
I
K
---
Q
I
E
S
-----
E
S
E
R
K
A
F
I
-
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
P
-------
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
G
A
E
P
-
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
-
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
T
A
C
------------------
G
S
A
A
W
M
A
P
E
V
F
E
---
G
S
N
Y
-
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
V
H
N
G
T
-
R
P
P
L
I
-
K
N
L
P
---
K
P
I
E
-------
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
58.97
38%
-16
- C3 -
-
5WNK
1
RIPK4_MOUSE
A:
[10-288]
-----
A
L
G
L
L
R
T
F
D
A
G
E
F
A
G
W
E
K
V
G
S
--
F
G
Q
V
Y
K
V
R
H
V
H
W
K
T
W
-
L
A
I
K
CSP
S
L
H
V
D
----
D
R
E
R
M
E
L
L
-
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
P
-------
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
L
L
A
S
E
P
-----
L
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
-
C
-
M
S
P
-
P
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
C
----------------
F
G
T
I
A
Y
L
P
P
E
R
I
R
--
E
K
S
R
L
F
D
T
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
A
D
E
K
N
I
-
L
H
I
M
M
K
V
V
K
G
H
-
R
P
E
L
P
P
I
C
R
P
---
R
--
P
R
A
C
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
--------------
T
F
Q
E
I
T
----------------
S
E
T
E
D
L
C
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
58.53
38%
-10
- C3 -
-
5WNI
1
RIPK4_MOUSE
A:
[9-288]
----
W
A
L
G
L
L
R
T
F
D
A
G
E
F
A
G
W
E
K
V
G
S
----
Q
V
Y
K
V
R
H
V
H
W
K
T
W
-
L
A
I
K
CSP
S
L
H
V
D
----
D
R
E
R
M
E
L
L
-
E
E
A
K
K
M
E
M
A
K
F
R
Y
I
L
P
V
Y
G
I
C
-
Q
E
P
-------
V
G
L
V
M
E
Y
M
E
T
G
S
L
E
K
L
L
A
S
E
P
-----
L
P
W
D
L
R
F
R
I
V
H
E
T
A
V
G
M
N
F
L
H
-
C
-
M
S
P
-
P
L
L
H
L
N
L
K
P
A
N
I
L
L
D
A
H
Y
H
V
-
K
I
S
D
F
G
L
A
K
C
N
---------------
F
G
T
I
A
Y
L
P
P
E
R
I
R
--
E
K
S
R
L
F
D
T
K
H
D
V
Y
S
F
A
I
V
I
W
G
V
L
T
Q
K
K
P
F
A
D
E
K
N
I
-
L
H
I
M
M
K
V
V
K
G
H
-
R
P
E
L
P
P
I
C
R
P
---
R
--
P
R
A
C
A
S
L
I
G
L
M
Q
R
C
W
H
A
D
P
Q
V
R
P
--------------
T
F
Q
E
I
T
----------------
S
E
T
E
D
L
C
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
58.50
31%
-40
- C3 -
-
4L3P
1
M3K7_HUMAN
A:
[1-266]
-------
G
S
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
---
W
R
A
K
D
V
A
I
K
---
Q
I
E
S
-----
E
S
E
R
K
A
F
I
-
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
P
-------
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
G
A
E
P
-
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
-
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
---------------------
G
S
A
A
W
M
A
P
E
V
F
E
---
G
S
N
Y
-
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
V
H
N
G
T
-
R
P
P
L
I
-
K
N
L
P
---
K
P
I
E
-------
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
Blastp_CBE
58.38
31%
-40
- C3 -
-
5V5N
1
M3K7_HUMAN
A:
[1-265]
--------
S
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
---
W
R
A
K
D
V
A
I
K
---
Q
I
E
S
-----
E
S
E
R
K
A
F
I
-
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
P
-------
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
G
A
E
P
-
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
-
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
T
--------------------
G
S
A
A
W
M
A
P
E
V
F
E
---
G
S
N
Y
-
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
V
H
N
G
T
-
R
P
P
L
I
-
K
N
L
P
---
K
P
I
E
-------
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
57.85
31%
-30
- C3 -
-
4L53
3
M3K7_HUMAN
A:
[1-266]
-------
G
S
L
H
M
I
D
Y
K
E
I
E
V
E
E
V
V
G
R
G
A
F
G
V
V
C
K
A
K
---
W
R
A
K
D
V
A
I
K
---
Q
I
E
S
-----
E
S
E
R
K
A
F
I
-
V
E
L
R
Q
L
S
R
V
N
H
P
N
I
V
K
L
Y
G
A
C
-
L
N
P
-------
V
C
L
V
M
E
Y
A
E
G
G
S
L
Y
N
V
L
H
G
A
E
P
-
L
P
Y
Y
T
A
A
H
A
M
S
W
C
L
Q
C
S
Q
G
V
A
Y
L
H
-
S
-
M
Q
P
K
A
L
I
H
R
D
L
K
P
P
N
L
L
L
V
A
G
G
T
V
L
K
I
C
D
F
G
T
-----------
K
--------
G
S
A
A
W
M
A
P
E
V
F
E
---
G
S
N
Y
-
S
E
K
C
D
V
F
S
W
G
I
I
L
W
E
V
I
T
R
R
K
P
F
D
E
I
G
G
P
A
F
R
I
M
W
A
V
H
N
G
T
-
R
P
P
L
I
-
K
N
L
P
---
K
P
I
E
-------
S
L
M
T
R
C
W
S
K
D
P
S
Q
R
P
S
M
E
E
I
V
K
I
M
T
H
L
M
R
Y
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
54.12
31%
-28
- C3 -
-
4YFF
1
TNI3K_HUMAN
C:
[33-306]
---------
L
P
S
H
F
H
L
Q
L
S
E
I
E
F
H
E
I
I
G
S
G
S
F
G
K
V
Y
K
G
R
C
R
N
K
I
V
A
I
K
---
R
Y
--------
S
D
V
D
M
F
C
-
R
E
V
S
I
L
C
Q
L
N
H
P
C
V
I
Q
F
V
G
A
C
L
N
D
P
S
Q
-----
F
A
I
V
T
Q
Y
I
S
G
G
S
L
F
S
L
L
H
E
Q
K
R
-
I
L
D
L
Q
S
K
L
I
I
A
V
--
D
V
A
K
G
M
E
Y
L
H
-
N
-
L
T
Q
-
P
I
I
H
R
D
L
N
S
H
N
I
L
L
Y
E
D
G
H
A
-
V
V
A
D
F
G
E
S
R
F
-
L
Q
S
-----------
Q
P
G
N
L
R
W
M
A
P
E
V
F
T
--
Q
C
T
R
Y
-
T
I
K
A
D
V
F
S
Y
A
L
C
L
W
E
I
L
T
G
E
I
P
F
A
H
L
-
K
P
-
A
A
A
A
A
D
M
A
Y
H
H
I
R
P
P
I
G
--------
Y
S
I
P
---
K
P
I
S
S
L
L
I
R
G
W
N
A
C
P
E
G
R
P
E
F
S
E
V
V
M
K
L
E
E
C
L
C
N
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
52.12
33%
-22
- C3 -
-
4M69
1
RIPK3_MOUSE
A:
[12-284]
-------
S
A
V
P
L
V
S
R
E
E
L
K
K
L
E
F
V
G
K
G
G
F
G
V
V
F
R
A
H
H
R
T
W
N
H
D
-
V
A
V
K
---
I
V
N
---------
S
K
K
I
S
-
W
E
V
K
A
M
V
N
L
R
N
E
N
V
L
L
L
L
G
V
T
-
E
D
L
Q
W
DFVSG
Q
A
L
V
T
R
F
M
E
N
G
S
L
A
G
L
L
Q
P
E
C
P
-
R
P
---
W
P
L
L
C
R
L
L
Q
E
V
V
L
G
M
C
Y
L
H
-
S
-
L
D
P
-
P
L
L
H
R
D
L
K
P
S
N
I
L
L
D
P
E
L
H
A
-
K
L
A
D
F
G
L
S
T
F
Q
G
G
-------------
G
G
T
L
A
Y
L
D
P
E
L
L
F
K
-
V
N
L
K
A
-
S
K
A
S
D
V
Y
S
F
G
I
L
V
W
A
V
L
A
G
R
E
--
A
E
L
V
D
K
-
L
I
R
E
T
V
C
D
R
Q
S
-
R
P
P
L
T
E
--
L
P
PGS
P
E
T
P
G
L
-
E
K
L
K
E
L
M
I
H
C
W
G
S
Q
S
E
N
R
P
S
F
Q
D
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
42.36
32%
-55
- C3 -
-
4OH4
1
BRI1_ARATH
A:
[50-246]
-----------------------
I
G
S
G
G
F
G
D
V
Y
K
A
I
L
K
D
G
S
A
--
V
A
I
K
---
K
L
-
I
H
V
S
--
G
Q
G
D
R
E
F
M
-
A
E
M
E
T
I
G
K
I
K
H
R
N
L
V
P
L
L
G
Y
C
-
K
V
G
D
E
-----
R
L
L
V
Y
E
F
M
K
Y
G
S
L
E
D
V
L
H
D
------
K
L
N
W
S
T
R
R
K
I
A
I
G
S
A
R
G
L
A
F
L
H
H
N
-
C
S
P
-
H
I
I
H
R
D
M
K
S
S
N
V
L
L
D
E
N
L
E
A
-
R
V
S
D
F
G
M
A
--
R
L
M
S
A
M
D
H
L
V
T
L
A
G
T
P
G
----
Y
V
P
P
E
Y
Y
Q
----
F
R
C
-
S
T
K
G
D
V
Y
S
Y
G
V
V
L
L
E
L
L
T
G
K
R
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
41.39
32%
-41
- C3 -
-
3UIM
1
A:
[38-236]
-----------------------
L
G
R
G
G
F
G
K
V
Y
K
G
R
L
A
D
G
T
-
L
-
V
A
V
K
---
R
L
K
E
-------
G
E
L
Q
F
Q
-
T
E
V
E
M
I
S
M
A
V
H
R
N
L
L
R
L
R
G
F
C
-
M
T
P
T
E
-----
R
L
L
V
Y
P
Y
M
A
N
G
S
V
A
S
C
L
R
E
R
P
E
S
Q
P
P
L
D
W
P
K
R
Q
R
I
A
L
G
S
A
R
G
L
A
Y
L
H
-
D
H
C
D
P
-
K
I
I
H
R
D
V
K
A
A
N
I
L
L
D
E
E
F
E
A
-
V
V
G
D
F
G
L
A
K
--
L
M
D
Y
K
D
H
V
A
V
R
G
------
I
G
H
I
A
P
E
Y
L
S
T
G
K
S
S
E
----
K
T
D
V
F
G
Y
G
V
M
L
L
E
L
I
T
G
Q
R
A
F
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
39.34
32%
-53
- C3 -
-
6EGF
1
IRAK4_HUMAN
B:
[52-224]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
---
N
-
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
S
E
K
---------------
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
39.23
32%
-63
- C3 -
-
6EGD
1
IRAK4_HUMAN
D:
[52-224]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
---
N
-
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-------------------
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
39.19
32%
-42
- C3 -
-
6O94
1
IRAK4_HUMAN
B:
[67-239]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
39.13
32%
-40
- C3 -
-
6UYA
1
?
B:
[67-239]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
174
Blastp_CBE
38.77
32%
-46
- C3 -
-
4Y73
1
IRAK4_HUMAN
C:
[52-224]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
38.69
32%
-43
- C3 -
-
6O95
1
IRAK4_HUMAN
D:
[67-239]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
---
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
38.69
32%
-38
- C3 -
-
6MOM
1
?
C:
[53-225]
--------------------------------------------
V
A
V
K
---
K
L
A
---
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
38.67
32%
-58
- C3 -
-
4U97
1
IRAK4_HUMAN
B:
[62-234]
--------------------------------------------
V
A
V
K
---
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
---
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
---
N
-
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
------------
V
M
T
S
R
I
V
---
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
38.62
32%
-39
- C3 -
-
4RMZ
1
IRAK4_HUMAN
A:
[57-229]
--------------------------------------------
V
A
V
K
---
K
L
A
----
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
38.60
32%
-52
- C3 -
-
6RFI
1
?
B:
[72-244]
--------------------------------------------
V
A
V
K
---
K
L
-------
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----------
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
38.54
32%
-51
- C3 -
-
6RFJ
1
?
B:
[72-244]
--------------------------------------------
V
A
V
K
---
K
L
--------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----------
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
38.49
32%
-64
- C3 -
-
6EGD
1
IRAK4_HUMAN
A:
[52-224]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
---
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
---
N
-
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-------------------
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
38.38
32%
-41
- C3 -
-
6MOM
1
?
A:
[53-225]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
38.27
32%
-50
- C3 -
-
6UYA
1
?
D:
[67-239]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
---
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
38.25
32%
-58
- C3 -
-
4U9A
1
IRAK4_HUMAN
B:
[62-234]
--------------------------------------------
V
A
V
K
---
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
---
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
---
N
-
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
------------
V
M
T
S
R
I
V
---
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
38.15
32%
-50
- C3 -
-
5K7G
1
IRAK4_HUMAN
B:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
---
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
--
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
-----------------
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
38.15
32%
-42
- C3 -
-
4RMZ
1
IRAK4_HUMAN
B:
[57-229]
--------------------------------------------
V
A
V
K
---
K
L
A
----
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
---
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
38.14
32%
-38
- C3 -
-
6O94
1
IRAK4_HUMAN
A:
[67-239]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
38.09
32%
-39
- C3 -
-
6N8G
1
IRAK4_HUMAN
C:
[47-219]
--------------------------------------------
V
A
V
K
---
K
L
A
---
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
37.99
32%
-53
- C3 -
-
4Y73
1
IRAK4_HUMAN
B:
[52-224]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
----
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
37.96
32%
-44
- C3 -
-
6N8G
1
IRAK4_HUMAN
B:
[47-219]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
37.95
32%
-45
- C3 -
-
5UIU
1
IRAK4_HUMAN
A:
[73-245]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
37.92
32%
-31
- C3 -
-
2OIC
1
IRAK4_HUMAN
A:
[40-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
---
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
37.89
32%
-53
- C3 -
-
5K72
1
IRAK4_HUMAN
D:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
-----
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
----------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
-----
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
37.89
32%
-47
- C3 -
-
5KX8
1
IRAK4_HUMAN
C:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
37.88
32%
-50
- C3 -
-
4ZTL
1
IRAK4_HUMAN
D:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
37.87
32%
-43
- C3 -
-
5KX7
1
IRAK4_HUMAN
B:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
37.80
32%
-42
- C3 -
-
4YO6
1
IRAK4_HUMAN
C:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
37.79
32%
-38
- C3 -
-
6MOM
2
?
D:
[53-225]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
37.76
32%
-48
- C3 -
-
6O95
1
IRAK4_HUMAN
C:
[67-239]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
---
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
37.73
32%
-47
- C3 -
-
4Y73
1
IRAK4_HUMAN
D:
[52-224]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
37.70
32%
-33
- C3 -
-
5UIS
1
IRAK4_HUMAN
A:
[62-248]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----------
V
M
S
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
37.70
32%
-45
- C3 -
-
5K75
1
IRAK4_HUMAN
C:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
-----
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
----
Q
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
37.69
32%
-42
- C3 -
-
5UIU
1
IRAK4_HUMAN
B:
[73-245]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
37.65
32%
-58
- C3 -
-
4U97
1
IRAK4_HUMAN
A:
[62-234]
--------------------------------------------
V
A
V
K
---
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-----------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
---
N
-
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
--------
T
V
M
T
S
R
I
V
---
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
37.65
32%
-42
- C3 -
-
4YP8
2
IRAK4_HUMAN
C:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
37.63
32%
-40
- C3 -
-
6O9D
1
IRAK4_HUMAN
B:
[67-239]
--------------------------------------------
V
A
V
K
---
K
L
A
----
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
--------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
37.59
32%
-51
- C3 -
-
2OIC
1
IRAK4_HUMAN
C:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
--------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
-------
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
37.48
32%
-57
- C3 -
-
4U9A
1
IRAK4_HUMAN
A:
[62-234]
--------------------------------------------
V
A
V
K
---
K
L
A
A
--------
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-----------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
---
N
-
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
--------
T
V
M
T
S
R
I
V
---
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
37.49
32%
-39
- C3 -
-
5K72
1
IRAK4_HUMAN
B:
[40-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
--
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
-----------------
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
37.48
32%
-35
- C3 -
-
5UIT
1
IRAK4_HUMAN
B:
[73-245]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
E
K
F
A
Q
---
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
37.44
32%
-52
- C3 -
-
5UIS
1
IRAK4_HUMAN
C:
[73-248]
--------------------------------------------
V
A
V
K
---
K
L
A
--------
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-----------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----------
V
M
S
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
37.42
32%
-38
- C3 -
-
6N8G
1
IRAK4_HUMAN
A:
[47-219]
--------------------------------------------
V
A
V
K
---
K
L
A
----
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
37.41
32%
-42
- C3 -
-
4Y73
1
IRAK4_HUMAN
A:
[52-224]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
37.39
32%
-39
- C3 -
-
6O8U
1
IRAK4_HUMAN
C:
[52-224]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
E
K
F
A
Q
T
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
37.36
32%
-45
- C3 -
-
5KX8
1
IRAK4_HUMAN
A:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
37.35
32%
-45
- C3 -
-
4ZTM
1
IRAK4_HUMAN
A:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
37.33
32%
-43
- C3 -
-
6O8U
1
IRAK4_HUMAN
D:
[52-224]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
-
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
----
Q
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
37.31
32%
-33
- C3 -
-
2NRU
1
IRAK4_HUMAN
B:
[57-229]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
E
K
F
A
Q
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
37.27
32%
-36
- C3 -
-
2NRU
1
IRAK4_HUMAN
A:
[57-229]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
E
K
F
A
Q
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
37.21
32%
-41
- C3 -
-
4ZTN
1
IRAK4_HUMAN
D:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
37.13
32%
-48
- C3 -
-
4ZTM
1
IRAK4_HUMAN
D:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
37.11
32%
-43
- C3 -
-
4ZTN
1
IRAK4_HUMAN
A:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
164
Blastp_CBE
37.11
32%
-62
- C3 -
-
6EG9
1
IRAK4_HUMAN
A:
[62-234]
--------------------------------------------
V
A
V
K
---
K
L
A
A
---
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
---
N
-
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
-----------------
V
---
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
37.09
32%
-44
- C3 -
-
4YO6
1
IRAK4_HUMAN
A:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
37.00
32%
-38
- C3 -
-
6MOM
2
?
B:
[53-225]
--------------------------------------------
V
A
V
K
---
K
L
A
A
---
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
36.94
32%
-45
- C3 -
-
6UYA
1
?
A:
[67-239]
--------------------------------------------
V
A
V
K
---
K
L
A
A
---
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
36.94
32%
-46
- C3 -
-
5KX8
1
IRAK4_HUMAN
D:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
36.93
32%
-41
- C3 -
-
5UIS
1
IRAK4_HUMAN
B:
[73-247]
--------------------------------------------
V
A
V
K
---
K
L
A
-------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
---
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
-----
V
M
S
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
36.87
32%
-41
- C3 -
-
6O95
1
IRAK4_HUMAN
A:
[67-239]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
--
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
36.84
32%
-40
- C3 -
-
5T1T
1
IRAK4_HUMAN
C:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
36.73
32%
-46
- C3 -
-
5K7G
1
IRAK4_HUMAN
D:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
---
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
-----
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
36.72
32%
-47
- C3 -
-
5K76
1
IRAK4_HUMAN
B:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
-----
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
-----
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
36.69
32%
-48
- C3 -
-
4XS2
1
IRAK4_HUMAN
D:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
36.68
32%
-40
- C3 -
-
4YP8
1
IRAK4_HUMAN
D:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
36.66
32%
-32
- C3 -
-
5T1T
1
IRAK4_HUMAN
B:
[40-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
---
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
36.66
32%
-33
- C3 -
-
2NRU
1
IRAK4_HUMAN
C:
[57-229]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
E
K
F
A
Q
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
36.64
32%
-32
- C3 -
-
6O9D
1
IRAK4_HUMAN
A:
[67-239]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
-------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
36.60
32%
-30
- C3 -
-
6N8G
1
IRAK4_HUMAN
D:
[36-219]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
36.54
32%
-46
- C3 -
-
4YO6
2
IRAK4_HUMAN
D:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
----
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
36.49
32%
-51
- C3 -
-
4ZTL
1
IRAK4_HUMAN
A:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
----
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
36.49
32%
-35
- C3 -
-
4ZTN
1
IRAK4_HUMAN
B:
[40-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
36.45
32%
-40
- C3 -
-
5T1T
1
IRAK4_HUMAN
A:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
---
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
163
Blastp_CBE
36.44
32%
-60
- C3 -
-
6EG9
1
IRAK4_HUMAN
B:
[62-234]
--------------------------------------------
V
A
V
K
---
K
L
A
A
---
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
---
N
-
H
H
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
------------------
V
---
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
36.40
32%
-49
- C3 -
-
5K72
1
IRAK4_HUMAN
C:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
-----
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
---------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
-----
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
36.27
32%
-36
- C3 -
-
6F3G
1
IRAK4_HUMAN
B:
[47-219]
--------------------------------------------
V
A
V
K
---
K
L
-------
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
---
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
----
Q
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
36.27
32%
-45
- C3 -
-
4XS2
1
IRAK4_HUMAN
A:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
36.21
32%
-55
- C3 -
-
6EGE
1
IRAK4_HUMAN
D:
[52-224]
--------------------------------------------
V
A
V
K
---
K
L
A
-------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
---
N
-
H
H
I
H
R
N
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
S
E
K
F
A
Q
T
V
M
T
S
--------
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
36.19
32%
-41
- C3 -
-
6F3I
1
IRAK4_HUMAN
B:
[72-244]
--------------------------------------------
V
A
V
K
---
K
L
-------
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
-----
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
36.19
32%
-33
- C3 -
-
5UIQ
1
IRAK4_HUMAN
C:
[73-247]
--------------------------------------------
V
A
V
K
---
K
L
A
A
----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
--
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
36.15
32%
-39
- C3 -
-
5W85
1
IRAK4_HUMAN
A:
[55-227]
--------------------------------------------
V
A
V
K
---
K
L
--------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
36.08
32%
-39
- C3 -
-
5T1T
1
IRAK4_HUMAN
D:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
36.07
32%
-44
- C3 -
-
5UIR
1
IRAK4_HUMAN
B:
[73-246]
--------------------------------------------
V
A
V
K
---
K
L
A
A
------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
--
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
36.04
32%
-43
- C3 -
-
6O95
1
IRAK4_HUMAN
B:
[67-239]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
--
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
36.05
32%
-40
- C3 -
-
6F3G
1
IRAK4_HUMAN
A:
[47-219]
--------------------------------------------
V
A
V
K
---
K
L
A
-----
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
--
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
---
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
36.04
32%
-42
- C3 -
-
5K7G
1
IRAK4_HUMAN
C:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
---
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
-----
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
36.04
32%
-26
- C3 -
-
2OID
1
IRAK4_HUMAN
B:
[40-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
---
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
35.98
32%
-31
- C3 -
-
2NRU
1
IRAK4_HUMAN
D:
[57-229]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
E
K
F
A
Q
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
35.93
32%
-46
- C3 -
-
5UIQ
1
IRAK4_HUMAN
B:
[73-247]
--------------------------------------------
V
A
V
K
---
K
L
A
A
------
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
--
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
35.85
32%
-44
- C3 -
-
6F3D
1
IRAK4_HUMAN
B:
[47-219]
--------------------------------------------
V
A
V
K
---
K
L
A
A
---
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
-----
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
159
Blastp_CBE
35.74
33%
-34
- C3 -
-
2NRY
1
IRAK4_HUMAN
B:
[57-229]
--------------------------------------------
V
A
V
K
---
K
L
A
A
---
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
S
-----
Q
T
V
M
S
R
I
V
---
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
35.62
32%
-41
- C3 -
-
5T1S
1
IRAK4_HUMAN
D:
[51-223]
--------------------------------------------
V
A
V
K
---
K
L
A
--------
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
--
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
35.61
32%
-41
- C3 -
-
6F3I
1
IRAK4_HUMAN
A:
[61-244]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
-
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
------------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
-----
T
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
35.53
32%
-47
- C3 -
-
5UIR
1
IRAK4_HUMAN
A:
[73-248]
--------------------------------------------
V
A
V
K
---
K
L
A
---
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-----
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-----
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
160
Blastp_CBE
35.45
33%
-33
- C3 -
-
2NRY
1
IRAK4_HUMAN
A:
[57-229]
--------------------------------------------
V
A
V
K
---
K
L
A
A
---
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
S
-----
Q
T
V
M
S
R
I
V
---
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
34.82
32%
-35
- C3 -
-
5UIQ
1
IRAK4_HUMAN
A:
[62-245]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
---------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
-
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
172
Blastp_CBE
25.34
32%
14
- C3 -
-
5W84
1
IRAK4_HUMAN
A:
[44-227]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
V
M
R
--
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
25.10
32%
20
- C3 -
-
5T1S
1
IRAK4_HUMAN
B:
[40-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
---
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
25.03
32%
10
- C3 -
-
5K7I
1
IRAK4_HUMAN
A:
[40-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
---------
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
E
-----
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
24.88
32%
9
- C3 -
-
6F3E
1
IRAK4_HUMAN
A:
[36-219]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
----------
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
------
M
S
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
24.80
32%
2
- C3 -
-
6O8U
2
IRAK4_HUMAN
A:
[29-224]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
-----
S
E
K
F
A
Q
T
V
M
R
I
V
G
T
T
A
Y
M
--------
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
24.26
32%
23
- C3 -
-
2OIC
1
IRAK4_HUMAN
B:
[40-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
---
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
24.20
32%
39
- C3 -
-
2OIC
1
IRAK4_HUMAN
D:
[40-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
E
K
F
A
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
158
Blastp_CBE
23.46
33%
31
- C3 -
-
2NRY
1
IRAK4_HUMAN
C:
[46-229]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
A
S
-
E
----
T
V
M
S
R
I
V
---
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
23.40
32%
24
- C3 -
-
4ZTM
1
IRAK4_HUMAN
B:
[40-223]
--------------------------------------------
V
A
V
K
---
K
L
A
A
M
V
D
I
T
T
E
E
L
K
Q
Q
F
D
Q
E
I
K
V
M
A
K
C
Q
H
E
N
L
V
E
L
L
G
F
S
-
S
D
G
D
D
-----
L
C
L
V
Y
V
Y
M
P
N
G
S
L
L
D
R
L
S
C
L
D
G
-
T
P
P
L
S
W
H
M
R
C
K
I
A
Q
G
A
A
N
G
I
N
F
L
H
-
E
-
N
H
H
---
I
H
R
D
I
K
S
A
N
I
L
L
D
E
A
F
T
A
-
K
I
S
D
F
G
L
A
R
------
A
S
----
Q
V
M
R
I
V
G
T
T
A
Y
M
A
P
E
----
A
L
R
G
E
I
-
T
P
K
S
D
I
Y
S
F
G
V
V
L
L
E
I
I
T
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------