@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ROR2_HUMAN: (2020-09-20 )
MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNAPEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA
Atome Classification :
(299 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460....---...470.......480.......490..---.-----------.---...500.----.--.....510..-.....-.520.......530........540.......550.......560...-----....570..--.....580...-....590--..---.......600.......610.......620..---.....630....--...640--...--.....650.......660.......670.......680.....-.-.690...-....700----...------..-------..710........720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MARGSALPRRP
L
L
C
I
P
A
V
W
A
A
A
A
L
L
L
S
VSRTSG
E
V
E
V
LDPNDPLGPLDGQDGPI
P
T
L
K
G
Y
F
L
N
F
L
EPVN
N
I
T
I
VQG
Q
T
A
I
L
H
C
K
VAGNPPPN
V
R
W
LKNDAPVVQEP
R
R
I
I
I
R
KTEYG
S
R
L
R
I
Q
DLDTTDTG
Y
Y
Q
C
V
ATNG
M
K
T
I
T
A
T
G
V
L
F
V
R
LGPTHSPNHNFQDDYHEDGFCQ
P
Y
R
G
I
A
C
A
R
F
IGN
R
T
I
Y
V
D
S
L
Q
MQ
G
E
I
EN
R
I
T
A
A
F
T
M
IGTSTH
L
S
D
Q
C
S
QFA
I
P
S
F
C
H
F
V
F
P
LCDARSRTP
K
P
R
E
L
C
R
D
E
C
E
V
L
E
S
D
L
C
R
Q
E
Y
T
IARSN
P
L
I
L
M
R
LQLPKCEALPMPESPDAA
N
C
M
RIGI
P
A
E
R
L
G
R
Y
H
Q
CYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGH
A
Y
CRNPGGQMEG
P
W
C
FTQNK
N
V
R
M
E
L
CDVPSCSPRDSSK
M
G
I
L
Y
I
LVPS
I
A
I
P
L
V
I
A
C
L
F
F
L
V
C
M
CRNKQKASAS
T
P
Q
R
R
Q
LMASPSQDMEMP
L
I
N
Q
H
K
Q
A
K
L
K
---
E
I
S
L
S
A
V
R
F
M
E
E
LGE
D
R
F
G
K
VYKGHLFG---P-----------A---PGEQ
T
Q
A
----
V
--
A
I
K
T
L
K
-
D
KA-EG
P
L
R
-
E
E
F
R
H
E
A
M
L
R
A
R
L-QHP
N
V
V
C
L
L
G
VVTKDQ
P
L
S
M
I
F
S
Y
CSHG
D
L
H
E
F
L
-----
V
MRSPHSDV--GSTDD
D
R
T
V
K
S-ALEP
P
----
D
F
---
V
H
L
V
A
Q
I
A
A
G
M
E
Y
L
S
SH
H
V
V
H
K
DLATR
N
V
L
V
Y
---
D
KL
N
V
K
I
S
D
L
G
L
--
F
R
E
V
Y
---
A
A
D
--
Y
Y
K
L
LGNSLL
P
I
R
WMAP
E
A
I
M
Y
GKFSID
S
D
I
W
S
Y
G
V
V
L
W
E
V
F
S
-Y-GLQPYCG-YS
N
Q
D
V
V
----
E
M
I
------RN-------RQV-LPCPDD
C
P
A
W
V
Y
A
L
M
I
E
C
W
N
EFPSRR
P
R
F
K
D
I
H
S
R
L
R
AWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQP
Q
F
IPMKGQIRPMVPPP
Q
L
Y
V
PVNGYQPVPAYGAYLPN
F
Y
P
V
QI
P
M
QMAPQQVPPQMVPKPSSHHSGSGSTST
G
Y
V
T
TAPSNT
S
M
A
D
R
A
A
L
L
SEGADDTQNAPED
G
A
Q
S
T
V
Q
E
A
E
E
EEEGSVP
E
T
E
LLGDCDT
L
Q
VDE
A
Q
V
Q
LEA
558
HHSearch
94.80
100%
-146
- C2 -
-
4GT4
-
B:
[19-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
---
E
I
S
L
S
A
V
R
F
M
E
E
L
G
E
D
R
F
G
K
V
Y
K
G
H
L
F
------------------------
T
Q
A
----
V
--
A
I
K
T
L
K
-
D
K
A
-
E
-
P
L
R
-
E
E
F
R
H
E
A
M
L
R
A
R
L
-
Q
H
P
N
V
V
C
L
L
G
V
V
T
K
D
Q
P
L
S
M
I
F
S
Y
C
S
H
G
D
L
H
E
F
L
-----
V
M
R
S
P
H
S
----------
R
T
V
K
S
-
A
L
E
P
P
----
D
F
---
V
H
L
V
A
Q
I
A
A
G
M
E
Y
L
S
S
H
H
V
V
H
K
D
L
A
T
R
N
V
L
V
Y
---
D
K
L
N
V
K
I
S
D
L
G
L
--
F
R
E
V
Y
---
A
A
D
--
Y
Y
K
L
L
G
N
S
L
L
P
I
R
W
M
A
P
E
A
I
M
Y
G
K
F
S
I
D
S
D
I
W
S
Y
G
V
V
L
W
E
V
F
S
-
Y
-
G
L
Q
P
Y
C
G
-
Y
S
N
Q
D
V
V
----
E
M
I
------
R
N
-------
R
Q
V
-
L
P
C
P
D
D
C
P
A
W
V
Y
A
L
M
I
E
C
W
N
E
F
P
S
R
R
P
R
F
K
D
I
H
S
R
L
R
A
W
G
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
94.34
100%
-153
- C2 -
-
4GT4
-
ROR2_HUMAN
A:
[19-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
---
E
I
S
L
S
A
V
R
F
M
E
E
L
G
E
D
R
F
G
K
V
Y
K
G
H
L
F
------------------------
T
Q
A
----
V
--
A
I
K
T
L
K
-
D
-
A
-
E
G
-
L
R
-
E
E
F
R
H
E
A
M
L
R
A
R
L
-
Q
H
P
N
V
V
C
L
L
G
V
V
T
K
D
Q
P
L
S
M
I
F
S
Y
C
S
H
G
D
L
H
E
F
L
-----
V
M
R
S
P
H
S
D
V
--
G
-----
R
T
V
K
S
-
A
L
E
P
P
----
D
F
---
V
H
L
V
A
Q
I
A
A
G
M
E
Y
L
S
S
H
H
V
V
H
K
D
L
A
T
R
N
V
L
V
Y
---
D
K
L
N
V
K
I
S
D
L
G
L
--
F
R
E
V
Y
---
A
A
D
--
Y
Y
K
L
L
G
N
S
L
L
P
I
R
W
M
A
P
E
A
I
M
Y
G
K
F
S
I
D
S
D
I
W
S
Y
G
V
V
L
W
E
V
F
S
-
Y
-
G
L
Q
P
Y
C
G
-
Y
S
N
Q
D
V
V
----
E
M
I
------
R
N
-------
R
Q
V
-
L
P
C
P
D
D
C
P
A
W
V
Y
A
L
M
I
E
C
W
N
E
F
P
S
R
R
P
R
F
K
D
I
H
S
R
L
R
A
W
G
N
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
559
HHSearch
90.36
100%
-150
- C2 -
-
3ZZW
-
ROR2_HUMAN
A:
[4-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
S
L
S
A
V
R
F
M
E
E
L
G
E
D
R
F
G
K
V
Y
K
G
H
L
F
G
---
P
-----------
A
---
P
G
E
Q
T
Q
A
----
V
--
A
I
K
T
L
K
-
D
K
A
-
E
G
P
L
R
-
E
E
F
R
H
E
A
M
L
R
A
R
L
-
Q
H
P
N
V
V
C
L
L
G
V
V
T
K
D
Q
P
L
S
M
I
F
S
Y
C
S
H
G
D
L
H
E
F
L
-----
V
M
R
------------------
S
-
A
L
E
P
P
----
D
F
---
V
H
L
V
A
Q
I
A
A
G
M
E
Y
L
S
S
H
H
V
V
H
K
D
L
A
T
R
N
V
L
V
Y
---
D
K
L
N
V
K
I
S
D
L
G
L
--
F
R
E
V
Y
---
A
A
D
--
Y
Y
K
L
L
G
N
S
L
L
P
I
R
W
M
A
P
E
A
I
M
Y
G
K
F
S
I
D
S
D
I
W
S
Y
G
V
V
L
W
E
V
F
S
-
Y
-
G
L
Q
P
Y
C
G
-
Y
S
N
Q
D
V
V
----
E
M
I
------
R
N
-------
R
Q
V
-
L
P
C
P
D
D
C
P
A
W
V
Y
A
L
M
I
E
C
W
N
E
F
P
S
R
R
P
R
F
K
D
I
H
S
R
L
R
A
W
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
90.16
99%
-150
- C2 -
-
3ZZW
-
ROR2_HUMAN
A:
[4-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
S
L
S
A
V
R
F
M
E
E
L
G
E
D
R
F
G
K
V
Y
K
G
H
L
F
G
---
P
-----------
A
---
P
G
E
Q
T
Q
A
----
V
--
A
I
K
T
L
K
-
D
K
A
-
E
G
P
L
R
-
E
E
F
R
H
E
A
M
L
R
A
R
L
-
Q
H
P
N
V
V
C
L
L
G
V
V
T
K
D
Q
P
L
S
M
I
F
S
Y
C
S
H
G
D
L
H
E
F
L
-----
V
M
R
------------------
S
-
A
L
E
P
P
----
D
F
---
V
H
L
V
A
Q
I
A
A
G
M
E
Y
L
S
S
H
H
V
V
H
K
D
L
A
T
R
N
V
L
V
Y
---
D
K
L
N
V
K
I
S
D
L
G
L
--
F
R
E
V
Y
---
A
A
D
--
Y
Y
K
L
L
G
N
S
L
L
P
I
R
W
M
A
P
E
A
I
M
Y
G
K
F
S
I
D
S
D
I
W
S
Y
G
V
V
L
W
E
V
F
S
-
Y
-
G
L
Q
P
Y
C
G
-
Y
S
N
Q
D
V
V
----
E
M
I
------
R
N
-------
R
Q
V
-
L
P
C
P
D
D
C
P
A
W
V
Y
A
L
M
I
E
C
W
N
E
F
P
S
R
R
P
R
F
K
D
I
H
S
R
L
R
A
W
G
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.42
44%
-145
- C2 -
-
4AT3
1
A:
[7-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
---
L
-----------
C
-------
K
I
L
----
V
--
A
V
K
T
L
---
A
S
-
D
N
A
-
R
-
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
-----
R
A
H
G
P
D
A
V
L
--
M
A
--
N
P
P
T
----
E
L
T
Q
S
----
Q
M
---
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
L
L
V
K
I
G
D
F
G
M
--
S
R
--
Y
---
S
T
D
--
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
N
E
V
I
----
E
C
I
------
T
Q
-------
G
R
V
-
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.44
44%
-147
- C2 -
-
4AT4
1
A:
[7-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
---
L
-----------
C
-------
K
I
L
----
V
--
A
V
K
T
L
K
-
D
A
S
-
D
N
A
-
R
-
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
-----
R
A
H
G
P
D
A
V
L
--
M
A
---
P
P
T
----
E
L
T
Q
S
----
Q
M
---
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
L
L
V
K
I
G
D
F
G
M
--
S
R
D
V
Y
---
S
T
D
--
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
N
E
V
I
----
E
C
I
------
T
Q
-------
G
R
V
-
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
77.02
44%
-141
- C2 -
-
4AT5
2
A:
[7-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
---
L
-------------------
K
I
L
----
V
--
A
V
K
T
L
K
-
D
A
S
-
D
N
A
-
R
-
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
-----
R
A
H
G
P
D
A
V
L
--
M
A
E
G
N
P
P
T
----
E
L
T
Q
S
----
Q
M
---
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
L
L
V
K
I
G
D
F
G
M
--
S
R
D
V
Y
---
S
T
D
--
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
N
E
V
I
----
E
C
I
------
T
Q
-------
G
R
V
-
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
75.85
43%
-129
- C2 -
-
4PMM
2
A:
[15-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
------
D
K
M
L
----
V
--
A
V
K
A
L
K
-----
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
75.83
39%
-144
- C2 -
-
2Y6O
1
A:
[4-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
---
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
-----
K
-----------
V
---
P
G
K
R
E
I
C
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
D
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
-----------------
R
K
N
D
G
R
F
T
V
I
-
Q
L
------------
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
--------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
-
Y
-
G
E
R
P
Y
W
D
-
M
S
N
Q
D
V
I
----
K
A
I
------
E
E
-------
G
Y
R
-
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
--
I
R
N
P
N
S
L
K
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
75.76
43%
-136
- C2 -
-
4PMS
1
A:
[15-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
------
D
K
M
L
----
V
--
A
V
K
A
L
K
-----
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
--
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
75.72
44%
-150
- C2 -
-
4ASZ
-
NTRK2_HUMAN
A:
[546-824]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
H
N
I
V
L
K
R
E
L
G
E
--
F
G
K
V
F
L
A
E
C
Y
N
---
L
-----------
C
-------
K
I
L
----
V
--
A
V
K
T
L
K
-
D
A
S
-
D
N
A
-
R
-
K
D
F
H
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
V
E
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
-----
R
A
H
G
P
D
A
V
L
--
M
----
P
P
T
----
E
L
T
Q
S
----
Q
M
---
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
L
L
V
K
I
G
D
F
G
M
--
S
R
D
V
Y
---
S
T
D
--
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
N
E
V
I
----
E
C
I
------
T
Q
-------
G
R
V
-
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.22
41%
-145
- C2 -
-
6KZD
1
?
A:
[3-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
---
L
-----------
S
---
P
T
K
D
K
M
L
----
V
--
A
V
K
A
L
K
-
D
P
T
-
L
A
A
-
R
-
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
-----
R
A
H
G
P
D
A
--------------
G
-
E
L
G
L
S
----
Q
M
---
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
A
N
L
L
V
K
I
G
D
F
G
M
--
S
R
D
V
Y
---
S
T
D
--
Y
Y
R
L
--
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
F
Q
-
L
S
N
T
E
V
I
----
E
C
I
------
T
Q
-------
G
R
V
-
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
75.14
43%
-150
- C2 -
-
4YMJ
4
NTRK3_HUMAN
A:
[9-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
---
L
-----------
S
---
P
T
K
D
K
M
L
----
V
--
A
V
K
A
L
K
-
D
P
T
-
L
A
A
-
R
-
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
-----
R
A
H
G
P
----------------
G
-
E
L
G
L
S
----
Q
M
---
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
A
N
L
L
V
K
I
G
D
F
G
-----
D
V
Y
---
S
T
D
--
Y
Y
R
---
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
F
Q
-
L
S
N
T
E
V
I
----
E
C
I
------
T
Q
-------
G
R
V
-
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
74.95
39%
-141
- C2 -
-
2Y6M
3
A:
[4-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
R
E
F
A
K
---
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
-----
K
-----------
V
---
P
G
K
R
E
I
C
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
D
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
-----------------
R
K
N
D
G
R
F
T
V
I
-
Q
L
------------
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
---------------------------
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
-
Y
-
G
E
R
P
Y
W
D
-
M
S
N
Q
D
V
I
----
K
A
I
------
E
E
-------
G
Y
R
-
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
--
I
R
N
P
N
S
L
K
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
576
HHSearch
74.84
40%
-144
- C2 -
-
2QOC
2
A:
[12-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
D
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
---
P
----------------
S
K
K
E
I
S
----
V
--
A
I
K
T
L
K
-
V
G
Y
-
T
E
K
Q
R
-
R
D
F
L
G
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
K
P
V
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
-----
R
K
H
D
-----------------
A
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
---
D
------------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
-
G
E
R
P
Y
W
E
-
M
S
N
Q
D
V
I
----
K
A
V
------
D
E
-------
G
Y
R
-
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
74.66
41%
-146
- C2 -
-
6KZC
1
?
A:
[3-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
---
L
-----------
S
---
P
T
K
D
K
M
L
----
V
--
A
V
K
A
L
K
-
D
P
T
-
L
A
A
-
R
-
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
-----
R
A
H
G
P
D
A
--------------
G
-
E
L
G
L
S
----
Q
M
---
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
A
N
L
L
V
K
I
G
D
F
G
M
--
S
R
-
V
Y
---
S
T
D
--
Y
Y
R
L
--
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
F
Q
-
L
S
N
T
E
V
I
----
E
C
I
------
T
Q
-------
G
R
V
-
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.44
43%
-139
- C2 -
-
5KMO
1
A:
[42-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-----
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
----
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
----
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
74.29
39%
-123
- C2 -
-
3EKN
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
---
I
-----------
I
---
K
G
E
A
E
T
R
----
V
--
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
A
E
N
--
N
P
G
R
P
P
P
T
L
Q
-----------
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
---
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
K
F
V
------
M
D
-------
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.25
43%
-137
- C2 -
-
5KMK
1
A:
[42-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-----
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
----
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
74.12
39%
-117
- C2 -
-
5HHW
2
?
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
---
I
-----------
I
---
K
G
E
A
E
T
R
----
V
--
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
A
E
N
--
N
P
G
R
P
P
P
T
L
Q
-----------
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
K
F
V
------
M
D
-------
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
74.04
44%
-143
- C2 -
-
6D20
2
A:
[39-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
--------------
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
73.95
40%
-146
- C2 -
-
2XYU
7
A:
[3-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
I
D
A
S
C
I
K
I
E
K
V
I
G
V
G
E
F
G
E
V
C
S
G
R
L
-----
K
-----------
V
---
P
G
K
R
E
I
C
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
D
K
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
H
L
E
G
V
V
T
K
C
K
P
V
M
I
I
T
E
Y
M
E
N
G
S
L
D
A
F
L
-----------------
R
K
N
D
G
R
F
T
V
I
-
Q
L
------------
V
G
M
L
R
G
I
G
S
G
M
K
Y
L
S
D
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
--------------------------
I
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
-
Y
-
G
E
R
P
Y
W
D
-
M
S
N
Q
D
V
I
----
K
A
I
------
E
E
-------
G
Y
R
-
L
P
P
P
M
D
C
P
I
A
L
H
Q
L
M
L
D
C
W
Q
K
E
R
S
D
R
P
K
F
G
Q
I
V
N
M
L
D
K
L
--
I
R
N
P
N
S
L
K
R
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
73.95
43%
-135
- C2 -
-
5KMM
1
A:
[42-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-----
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
----
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
73.79
44%
-137
- C2 -
-
6PL3
1
A:
[31-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
-
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
------
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
73.79
43%
-152
- C2 -
-
3V5Q
1
B:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
H
V
Q
---
H
I
K
R
R
D
I
V
L
K
R
E
L
G
---
F
-
K
V
F
L
A
E
C
Y
N
---
L
-----------
S
---
P
T
K
D
K
M
L
----
V
--
A
V
K
A
L
K
-
D
P
T
-
L
A
A
-
R
-
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
--
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
-----
R
A
H
G
P
------------------
E
L
G
L
S
----
Q
M
---
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
A
N
L
L
V
K
I
G
D
F
G
M
----
D
V
Y
---
S
T
D
--
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
F
Q
-
L
S
N
T
E
V
I
----
E
C
I
------
T
Q
-------
G
R
V
-
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
73.73
42%
-157
- C2 -
-
3V5Q
1
NTRK3_HUMAN
A:
[6-294]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
I
H
V
Q
---
H
I
K
R
R
D
I
V
L
K
R
E
L
------
K
V
F
L
A
E
C
Y
N
---
L
-----------
S
---
P
T
K
D
K
M
L
----
V
--
A
V
K
A
L
---
P
T
-
L
A
A
-
R
-
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
D
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
-----
R
A
H
G
P
------------------
E
L
G
L
S
----
Q
M
---
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
A
N
L
L
V
K
I
G
D
F
G
M
----
D
V
Y
---
S
T
D
--
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
F
Q
-
L
S
N
T
E
V
I
----
E
C
I
------
T
Q
-------
G
R
V
-
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
73.68
43%
-134
- C2 -
-
4PMP
1
A:
[15-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
-------
K
M
L
----
V
--
A
V
K
A
L
K
------
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
-
I
Y
---
S
T
D
--
Y
Y
R
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
73.46
43%
-137
- C2 -
-
5KMJ
1
A:
[42-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
---
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
------
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
73.30
44%
-133
- C2 -
-
6NSS
1
A:
[31-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-----
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
73.15
43%
-136
- C2 -
-
5KMI
1
A:
[42-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-----
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
-----
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
72.98
44%
-134
- C2 -
-
6NSP
1
A:
[16-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
-----
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
300
Blastp_CBE
72.91
37%
-155
- C2 -
-
4D4V
2
B:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
M
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
F
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
C
V
K
L
G
D
F
G
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
72.76
44%
-139
- C2 -
-
6DKI
2
A:
[39-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
---------------
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
----
R
D
I
Y
---
S
T
D
--
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
72.67
43%
-136
- C2 -
-
5H3Q
3
A:
[43-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
-----------------------
K
M
L
----
V
--
A
V
K
A
L
K
-
E
-----
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
72.61
44%
-151
- C2 -
-
6DKW
1
NTRK1_HUMAN
A:
[27-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
----
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
-------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
72.59
44%
-130
- C2 -
-
5KVT
2
A:
[15-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
------------------
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
72.52
43%
-133
- C2 -
-
5KML
1
A:
[43-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
--
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
-
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
-------
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
72.51
44%
-145
- C2 -
-
6DKG
2
A:
[39-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
---------------
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
-------
Y
---
S
T
D
--
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
72.33
37%
-147
- C2 -
-
4D58
1
?
B:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
M
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
F
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
C
V
K
L
G
D
F
G
L
--
S
R
Y
M
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
72.27
44%
-138
- C2 -
-
6D1Y
1
A:
[39-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
------
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
------------
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
301
Blastp_CBE
72.25
37%
-154
- C2 -
-
4D4V
2
FAK1_CHICK
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
M
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
F
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
C
V
K
L
G
D
F
------------------------
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
72.22
39%
-126
- C2 -
-
1I44
1
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
---
I
-----------
I
---
K
G
E
A
E
T
R
----
V
--
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
A
E
N
--
N
P
G
R
P
P
P
T
L
Q
-----------
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
--
T
---------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
K
F
V
------
M
D
-------
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
72.22
44%
-139
- C2 -
-
6D1Z
3
A:
[39-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
---------------
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
72.15
44%
-150
- C2 -
-
6DKB
1
A:
[39-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
----------------
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
-----------
S
T
D
--
Y
Y
R
-----
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
72.11
43%
-134
- C2 -
-
5KMN
1
A:
[43-311]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
--
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
-
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
-------
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
564
HHSearch
71.90
38%
-110
- C2 -
-
6BSD
1
DDR1_HUMAN
A:
[567-872]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
-----------------------
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
A
-----------
G
P
-
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
----
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
-
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
----
E
N
A
------
G
E
FFRDQGR
Q
V
Y
-
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
305
Blastp_CBE
71.82
37%
-145
- C2 -
-
4C7T
1
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
M
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
F
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
C
V
K
L
G
D
F
G
L
--
S
R
Y
M
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
71.81
37%
-149
- C2 -
-
4D4S
1
B:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
M
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
F
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
C
V
K
L
G
D
F
G
L
--
S
R
Y
M
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
71.72
37%
-147
- C2 -
-
4BRX
1
FAK1_CHICK
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
-
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
M
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
F
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
C
V
K
L
G
D
F
G
L
--
S
R
Y
M
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
71.71
44%
-151
- C2 -
-
4AOJ
1
NTRK1_HUMAN
B:
[48-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
---
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
---------------
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
--------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
574
HHSearch
71.69
33%
-127
- C2 -
-
4CKJ
16
A:
[19-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
---
L
-----------
K
---
G
R
A
G
Y
T
T
----
V
--
A
V
K
M
L
K
-
E
N
A
-
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
-----
R
E
S
R
K
V
---------------
R
-
A
L
T
M
G
----
D
L
---
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
--
S
R
D
V
Y
---
E
E
D
--
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
-
G
G
N
P
Y
P
G
-
I
P
P
E
R
L
F
----
N
L
L
------
K
T
-------
G
H
R
-
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
71.61
44%
-149
- C2 -
-
4AOJ
1
C:
[48-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
-
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
---------------
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
-----------------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
71.46
37%
-149
- C2 -
-
2JKK
1
?
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
M
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
F
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
C
V
K
L
G
D
F
G
L
--
S
R
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
71.42
44%
-153
- C2 -
-
5JFV
1
A:
[27-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
-------------
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
-------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
563
HHSearch
71.39
38%
-122
- C2 -
-
6BRJ
1
DDR1_HUMAN
A:
[568-872]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
--------------------------
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
--------------
P
-
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
-
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
----
E
N
A
------
G
E
FFRDQGR
Q
V
Y
-
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
71.29
37%
-148
- C2 -
-
2JKO
1
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
M
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
F
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
C
V
K
L
G
D
F
G
L
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
71.06
39%
-114
- C2 -
-
6FIL
1
A:
[16-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
-------------------
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
--------
S
A
H
Q
L
E
--
D
K
A
A
E
G
A
P
G
D
P
-
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
71.05
44%
-135
- C2 -
-
6J5L
1
A:
[22-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
------------------
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
------
I
Y
---
S
T
D
--
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
71.04
44%
-147
- C2 -
-
5JFX
1
A:
[27-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
-------------
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
-------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
71.04
44%
-155
- C2 -
-
6DKW
1
B:
[27-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
-------------
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
-----------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
70.91
44%
-150
- C2 -
-
5JFW
1
A:
[27-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
-------------
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
-------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.86
43%
-150
- C2 -
-
4AOJ
1
NTRK1_HUMAN
A:
[48-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
---
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
--------------
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
-----------------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
70.78
44%
-132
- C2 -
-
4YNE
2
A:
[22-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
--
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
-------
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
----------
S
T
D
--
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
70.74
44%
-148
- C2 -
-
5JFS
1
A:
[27-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
-------------
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
-------------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
70.62
37%
-154
- C2 -
-
6I8Z
1
A:
[8-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
R
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
70.51
41%
-137
- C2 -
-
6FNJ
2
B:
[12-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
-----
K
-----------
A
---
P
G
K
K
E
S
C
----
V
--
A
I
K
T
L
K
-
G
G
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
-
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----
R
L
-----------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
-
F
-
G
E
R
P
Y
W
D
-
M
S
N
Q
D
V
I
----
N
A
I
------
E
Q
-------
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
70.44
37%
-153
- C2 -
-
6GCX
1
FAK1_CHICK
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
M
A
----
V
--
A
I
K
T
C
K
-
N
---
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
F
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
A
T
D
C
V
K
L
G
D
F
G
L
--
S
R
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
70.37
43%
-139
- C2 -
-
4PMT
1
A:
[15-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
------------------
D
K
M
L
----
V
--
A
V
K
A
L
-------------
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
----
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
L
A
Q
A
H
H
H
H
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
70.34
37%
-158
- C2 -
-
3PXK
1
FAK1_HUMAN
A:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
70.21
37%
-165
- C2 -
-
4KAB
1
FAK1_HUMAN
A:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
--
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
557
HHSearch
70.08
33%
-132
- C2 -
-
5FM3
1
A:
[60-351]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
---
L
-----------
K
---
G
R
A
G
Y
T
T
----
V
--
A
V
K
M
L
K
-
E
N
A
-
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
-----
R
E
S
--------------------
A
L
T
M
G
----
D
L
---
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
--
S
R
D
V
Y
---
E
E
D
--
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
-
G
G
N
P
Y
P
G
-
I
P
P
E
R
L
F
----
N
L
L
------
K
T
-------
G
H
R
-
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
70.05
37%
-151
- C2 -
-
2JKQ
1
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
69.99
41%
-136
- C2 -
-
6FNJ
1
EPHB4_HUMAN
A:
[12-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
-----
K
-----------
A
---
P
G
K
K
E
S
C
----
V
--
A
I
K
T
L
K
-
G
G
Y
-
T
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
-
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----
R
L
-----------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
-----------------------
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
-
F
-
G
E
R
P
Y
W
D
-
M
S
N
Q
D
V
I
----
N
A
I
------
E
Q
-------
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
69.96
37%
-149
- C2 -
-
4KAB
1
B:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
-
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
R
Y
M
------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
69.91
37%
-144
- C2 -
-
4K8A
1
B:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
R
Y
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
69.87
37%
-153
- C2 -
-
3PXK
1
B:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
69.85
37%
-162
- C2 -
-
2J0M
1
?
B:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
573
HHSearch
69.77
33%
-130
- C2 -
-
6FEK
3
A:
[19-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
---
L
-----------
K
---
G
R
A
G
Y
T
T
----
V
--
A
V
K
M
L
K
-
E
N
A
-
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
G
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
-----
R
E
S
R
K
V
G
---------
P
G
P
D
E
R
-
A
L
T
M
G
----
D
L
---
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
--
S
R
D
V
Y
---
E
E
D
--
F
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
-
G
G
N
P
Y
P
G
-
I
P
P
E
R
L
F
----
N
L
L
------
K
T
-------
G
H
R
-
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
M
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
69.70
37%
-150
- C2 -
-
2JKM
1
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
M
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
R
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
69.50
40%
-147
- C2 -
-
3DKO
1
A:
[38-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
E
L
D
A
S
C
I
K
I
E
R
V
I
G
A
-
E
F
G
E
V
C
S
G
R
L
-----
K
-----------
L
---
P
G
K
R
D
V
A
----
V
--
A
I
K
T
L
K
-
V
G
Y
-
T
E
K
Q
R
-
R
D
F
L
C
E
A
S
I
M
G
Q
F
-
D
H
P
N
V
V
H
L
E
G
V
V
T
R
G
K
P
V
M
I
V
I
E
F
M
E
N
G
A
L
D
A
F
L
----------------------
R
K
H
D
G
-
Q
F
T
V
I
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
R
Y
L
A
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
V
R
W
T
A
P
E
A
I
Q
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
-
Y
-
G
E
R
P
Y
W
D
-
M
S
N
Q
D
V
I
----
K
A
I
------
E
E
-------
G
Y
R
-
L
P
A
P
M
D
C
P
A
G
L
H
Q
L
M
L
D
C
W
Q
K
E
R
A
E
R
P
K
F
E
Q
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
69.44
37%
-160
- C2 -
-
4GU9
1
FAK1_HUMAN
A:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
--
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
69.36
37%
-149
- C2 -
-
2IJM
1
FAK1_HUMAN
A:
[8-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
69.34
37%
-139
- C2 -
-
4GU6
1
FAK1_HUMAN
A:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
-----
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
R
Y
M
E
---
D
S
T
--
Y
Y
K
A
-
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
69.30
37%
-153
- C2 -
-
4I4E
1
A:
[11-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
-
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
--------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
69.18
37%
-153
- C2 -
-
2IJM
1
B:
[8-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
69.13
37%
-152
- C2 -
-
4K8A
1
FAK1_HUMAN
A:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
--
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
-------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
69.12
37%
-151
- C2 -
-
2ETM
1
FAK1_HUMAN
A:
[8-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
R
Y
M
E
----------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
69.01
44%
-134
- C2 -
-
4YPS
1
A:
[22-290]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
------
D
K
M
L
----
V
--
A
V
K
A
L
----
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
--
M
--
S
R
D
I
Y
---
S
T
D
--
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
68.91
37%
-151
- C2 -
-
4GU6
1
B:
[9-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
R
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
68.40
39%
-58
- C2 -
-
3ETA
1
INSR_HUMAN
A:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
---
I
-----------
I
---
K
G
E
A
E
T
R
----
V
--
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
A
E
------------
N
N
-
P
G
R
P
P
PTLQ
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
K
-
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
K
F
V
------
M
D
-------
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
68.08
37%
-146
- C2 -
-
2ETM
1
B:
[8-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
R
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
68.08
38%
-73
- C2 -
-
3LVP
2
IGF1R_HUMAN
A:
[43-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
M
E
----
P
V
----------
L
A
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
------------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
67.96
38%
-66
- C2 -
-
3I81
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
-
E
N
--
N
P
V
----------
L
A
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
67.96
44%
-140
- C2 -
-
5I8A
1
A:
[18-283]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
-----------------------
K
M
L
----
V
--
A
V
K
A
L
K
------------
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
---
S
R
D
I
----
S
T
D
--
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
67.85
37%
-146
- C2 -
-
1MP8
1
A:
[11-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
--
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
---------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
67.75
37%
-153
- C2 -
-
4Q9S
1
A:
[11-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
--
P
A
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
---------------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
67.75
39%
-60
- C2 -
-
3ETA
1
B:
[12-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
---
I
-----------
I
---
K
G
E
A
E
T
R
----
V
--
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
A
E
------------
N
N
-
P
G
R
P
P
PTLQ
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
K
F
V
------
M
D
-------
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
67.50
38%
-57
- C2 -
-
3NW6
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
M
E
N
--
N
P
V
----------
L
A
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Blastp_CBE
67.50
38%
-59
- C2 -
-
3NW7
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
M
E
N
--
N
P
V
----------
L
A
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
67.48
37%
-146
- C2 -
-
3BZ3
1
A:
[3-263]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
----
L
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
Y
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
R
Y
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
67.35
41%
-109
- C2 -
-
5L6P
2
A:
[20-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
-----
K
-----------
Q
---
P
G
R
R
E
V
F
----
V
--
A
I
K
T
L
K
-
V
G
Y
-
T
E
R
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
R
P
V
M
I
L
T
E
F
M
E
N
C
A
L
D
S
F
L
-----
R
L
-----------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
SR
F
L
E
D
D
---
P
S
D
PT
Y
T
S
S
L
G
G
K
I
-
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
-
Y
-
G
E
R
P
Y
W
D
-
M
S
N
Q
D
V
I
----
N
A
V
------
E
Q
-------
D
Y
R
-
L
P
P
P
M
D
C
P
T
A
L
H
Q
L
M
L
D
C
W
V
R
D
R
N
L
R
P
K
F
S
Q
I
V
N
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
67.13
43%
-118
- C2 -
-
4YMJ
4
B:
[9-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
---
H
I
K
R
R
D
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
---
L
-----------
S
---
P
T
K
D
K
M
L
----
V
--
A
V
K
A
L
K
-
D
P
T
-
L
A
A
-
R
-
K
D
F
Q
R
E
A
E
L
L
T
N
L
-
Q
H
E
H
I
V
K
F
Y
G
V
C
G
D
G
-
P
L
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
-----
R
A
H
G
P
----------------
G
-
E
L
G
L
S
----
Q
M
---
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
A
N
L
L
V
K
I
G
D
F
G
M
--
S
R
D
V
Y
---
T
-
D
--
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
F
Q
-
L
S
N
T
E
V
I
----
E
C
I
------
T
Q
-------
G
R
V
-
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
L
N
I
K
E
I
Y
K
I
L
H
A
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Blastp_CBE
66.31
38%
-91
- C2 -
-
5BVN
1
A:
[19-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
----------------------
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
--------------P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
66.18
44%
-110
- C2 -
-
6PL2
1
A:
[31-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
T
-
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Blastp_CBE
65.99
38%
-66
- C2 -
-
1JQH
1
C:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
-------
V
----------
L
A
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
------------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
65.87
38%
-76
- C2 -
-
6BSD
1
DDR1_HUMAN
A:
[571-868]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
-----------------------
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
A
------------
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
----
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
----
E
N
A
GEFFRD
Q
G
-------
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Blastp_CBE
65.86
38%
-66
- C2 -
-
1JQH
1
IGF1R_HUMAN
B:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-----
R
S
L
R
P
---------------------
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
------------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
146
Blastp_CBE
65.81
38%
-58
- C2 -
-
3LW0
2
IGF1R_HUMAN
A:
[11-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-------
R
S
L
R
P
-------------------
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
144
Blastp_CBE
65.71
38%
-56
- C2 -
-
3LW0
3
IGF1R_HUMAN
C:
[11-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-------
R
S
L
R
P
-------------------
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
65.67
38%
-57
- C2 -
-
3LW0
3
IGF1R_HUMAN
B:
[11-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-------
R
S
L
R
P
-------------------
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
104
Blastp_CBE
65.60
38%
-69
- C2 -
-
1JQH
1
IGF1R_HUMAN
A:
[15-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
-------
V
----------
L
A
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
------------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
65.52
41%
-90
- C2 -
-
5L6O
2
A:
[20-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
C
V
K
I
E
E
V
I
G
A
---
G
E
V
C
R
G
R
L
-----
K
-----------
Q
---
P
G
R
R
E
V
F
----
V
--
A
I
K
T
L
K
-
V
G
Y
-
T
E
R
Q
R
-
R
D
F
L
S
E
A
S
I
M
G
Q
F
-
D
H
P
N
I
I
R
L
E
G
V
V
T
K
S
R
P
V
M
I
L
T
E
F
M
E
N
C
A
L
D
S
F
L
-----
R
L
-----------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
S
E
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
----
L
E
D
D
---
P
S
D
PT
Y
T
S
S
L
G
G
K
I
-
P
I
R
W
T
A
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
-
Y
-
G
E
R
P
Y
W
D
-
M
S
N
Q
D
V
I
----
N
A
V
------
E
Q
-------
D
Y
R
-
L
P
P
P
M
D
C
P
T
A
L
H
Q
L
M
L
D
C
W
V
R
D
R
N
L
R
P
K
F
S
Q
I
V
N
T
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
555
Blastp_CBE
65.50
36%
-72
- C2 -
-
6T2W
1
?
A:
[35-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
---
L
-----------
G
---
K
E
D
A
V
L
K
----
V
--
A
V
K
M
L
K
-
S
T
A
-
H
A
D
E
K
-
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
RRKAE
A
M
L
------------------
R
-
P
L
E
L
R
----
D
L
---
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
--
A
R
D
I
M
---
N
D
S
--
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
----
K
L
V
------
K
D
-------
G
Y
Q
-
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
65.45
36%
-70
- C2 -
-
3KRJ
1
A:
[42-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
---
L
-----------
G
---
K
E
D
A
V
L
K
----
V
--
A
V
K
M
L
K
-
S
T
A
-
H
A
D
E
K
-
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-----
R
R
K
R
P
P
G
----------------
Q
L
S
S
R
----
D
L
---
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
--
A
R
D
I
M
---
N
D
S
--
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
----
K
L
V
------
K
D
-------
G
Y
Q
-
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
108
Blastp_CBE
65.35
38%
-57
- C2 -
-
2OJ9
1
A:
[14-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
--------------------
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
110
Blastp_CBE
65.34
38%
-90
- C2 -
-
5BVO
1
A:
[19-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
--
F
G
E
V
H
L
C
E
V
D
S
----------------------
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
--------------P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
65.28
37%
-70
- C2 -
-
3BEA
1
A:
[48-322]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
---
L
-----------
G
---
K
E
D
A
V
L
K
----
V
--
A
V
K
M
L
K
-
S
T
A
-
H
A
D
E
K
-
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-----
R
R
K
S
---
R
V
--
L
---------
S
-
T
L
S
T
R
----
D
L
---
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
--
A
R
D
I
M
---
N
D
S
--
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
----
K
L
V
------
K
D
-------
G
Y
Q
-
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
65.18
36%
-69
- C2 -
-
2I0V
1
A:
[42-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
---
L
-----------
G
---
K
E
D
A
V
L
K
----
V
--
A
V
K
M
L
K
-
S
T
A
-
H
A
D
E
K
-
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-----
R
R
K
R
-------------------
Q
L
S
S
R
----
D
L
---
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
--
A
R
D
I
M
---
N
D
S
--
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
----
K
L
V
------
K
D
-------
G
Y
Q
-
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
65.09
36%
-69
- C2 -
-
3LCD
1
?
A:
[42-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
---
L
-----------
G
---
K
E
D
A
V
L
K
----
V
--
A
V
K
M
L
K
-
S
T
A
-
H
A
D
E
K
-
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-----
R
R
K
A
--------
E
A
D
L
D
------
P
L
E
L
R
----
D
L
---
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
--
A
R
D
I
M
-----
S
--
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
----
K
L
V
------
K
D
-------
G
Y
Q
-
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
65.00
36%
-68
- C2 -
-
6N33
1
A:
[52-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
---
L
-----------
G
---
K
E
D
A
V
L
K
----
V
--
A
V
K
M
L
K
-
S
T
A
-
H
A
D
E
K
-
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
RRKAE
A
M
L
G
P
S
L
S
------------
G
R
-
P
L
E
L
R
----
D
L
---
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
--
A
R
D
I
M
---
N
D
S
--
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
----
K
L
V
------
K
D
-------
G
Y
Q
-
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
65.00
38%
-56
- C2 -
-
3LW0
2
D:
[11-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
A
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
---
V
-----------
V
---
K
D
E
P
E
T
R
----
V
--
A
I
K
T
V
N
-
E
A
A
-
S
M
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
-------
R
S
L
R
P
-------------------
P
P
----
S
L
SKM
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
---
E
T
D
--
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
R
F
V
------
M
E
-------
G
G
L
-
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
I
S
S
I
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
64.94
38%
-78
- C2 -
-
6BRJ
1
DDR1_HUMAN
A:
[571-868]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
--------------------------
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
---------------P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
----
E
N
A
GEFFRD
Q
G
-------
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
497
Blastp_CBE
64.93
36%
-70
- C2 -
-
3KRL
1
A:
[42-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
---
L
-----------
G
---
K
E
D
A
V
L
K
----
V
--
A
V
K
M
L
K
-
S
T
A
--
A
D
E
K
-
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-----
R
R
K
R
-------------------
Q
L
S
S
R
----
D
L
---
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
--
A
R
D
I
M
---
N
D
S
--
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
----
K
L
V
------
K
D
-------
G
Y
Q
-
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
64.80
36%
-70
- C2 -
-
4R7I
1
?
A:
[52-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
---
L
-----------
G
---
K
E
D
A
V
L
K
----
V
--
A
V
K
M
L
K
-
S
T
A
-
H
A
D
E
K
-
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
RRKAE
A
M
L
G
P
S
L
S
------------
G
R
-
P
L
E
L
R
----
D
L
---
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
--
A
R
D
I
M
---
N
D
S
--
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
----
K
L
V
------
K
D
-------
G
Y
Q
-
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
112
Blastp_CBE
64.75
38%
-83
- C2 -
-
5BVK
1
A:
[19-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
----------------------
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
--------------P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
109
Blastp_CBE
64.48
38%
-88
- C2 -
-
5BVW
1
A:
[19-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
----------------------
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
--------------P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
------
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
64.46
36%
-71
- C2 -
-
4HW7
1
A:
[52-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
---
L
-----------
G
---
K
E
D
A
V
L
K
----
V
--
A
V
K
M
L
K
-
S
T
A
-
H
A
D
E
K
-
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
T
Y
G
D
L
L
N
F
L
RRKAE
A
M
L
G
P
S
--------------
G
R
-
P
L
E
L
R
----
D
L
---
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
--
A
R
D
I
M
---
N
D
S
--
N
Y
I
V
K
G
N
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
S
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
----
K
L
V
------
K
D
-------
G
Y
Q
-
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
T
S
F
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
64.36
41%
-81
- C2 -
-
6FNI
1
A:
[12-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
K
---
E
I
D
V
S
Y
V
K
I
E
E
V
I
G
A
G
E
F
G
E
V
C
R
G
R
L
-----
K
-----------
A
---
P
G
K
K
E
S
C
----
V
--
A
I
K
T
L
-------
E
R
Q
R
-
R
E
F
L
S
E
A
S
I
M
G
Q
F
-
E
H
P
N
I
I
R
L
E
G
V
V
T
N
S
M
P
V
M
I
L
T
E
F
M
E
N
G
A
L
D
S
F
L
-----
R
L
-----------
N
D
G
Q
F
T
V
I
Q
-----------
L
---
V
G
M
L
R
G
I
A
S
G
M
R
Y
L
A
E
M
S
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
SR
F
--------------------
I
-
P
I
R
W
T
A
P
E
A
I
A
F
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
M
W
E
V
M
S
-
F
-
G
E
R
P
Y
W
D
-
M
S
N
Q
D
V
I
----
N
A
I
------
E
Q
-------
D
Y
R
-
L
P
P
P
P
D
C
P
T
S
L
H
Q
L
M
L
D
C
W
Q
K
D
R
N
A
R
P
R
F
P
Q
I
V
S
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
64.34
39%
-45
- C2 -
-
6FIQ
1
A:
[16-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QD-----------------
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
--------
S
A
H
Q
L
E
--
D
K
A
A
E
G
A
P
G
D
P
-
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
551
Blastp_CBE
63.98
34%
-92
- C2 -
-
3AOX
5
A:
[39-316]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
K
---
E
V
P
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
V
------------------------
S
P
L
Q
----
V
--
A
V
K
T
L
P
-
E
V
C
-
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
-----
R
E
T
R
P
R
P
-----------
S
Q
P
S
-
S
L
A
M
L
----
D
L
---
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
--
A
R
D
I
Y
---
R
A
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
-
G
Y
M
P
Y
P
S
-
K
S
N
Q
E
V
L
----
E
F
V
------
T
S
-------
G
G
R
-
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
133
Blastp_CBE
63.63
39%
-35
- C2 -
-
6FEW
1
A:
[16-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVS------
V
---
R
K
G
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
--------
S
A
H
Q
L
E
--
D
K
A
A
------
P
-
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
63.53
36%
-65
- C2 -
-
2I0Y
1
?
A:
[42-324]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
P
R
N
N
L
Q
F
G
K
T
L
G
A
G
A
F
G
K
V
V
E
A
T
A
F
G
---
L
-----------
G
---
K
E
D
A
V
L
K
----
V
--
A
V
K
M
L
K
-
S
T
A
-
H
A
D
E
K
-
E
A
L
M
S
E
L
K
I
M
S
H
L
G
Q
H
E
N
I
V
N
L
L
G
A
C
T
H
G
G
P
V
L
V
I
T
E
Y
C
C
Y
G
D
L
L
N
F
L
-----
R
R
K
R
-------------------
Q
L
S
S
R
----
D
L
---
L
H
F
S
S
Q
V
A
Q
G
M
A
F
L
A
S
K
N
C
I
H
R
D
V
A
A
R
N
V
L
L
T
---
N
G
H
V
A
K
I
G
D
F
G
L
--
A
R
D
I
M
---
N
D
S
--
N
Y
I
V
K
G
-
A
R
L
P
V
K
W
M
A
P
E
S
I
F
D
C
V
Y
T
V
Q
S
D
V
W
S
Y
G
I
L
L
W
E
I
F
S
-
L
-
G
L
N
P
Y
P
G
I
L
V
N
S
K
F
Y
----
K
L
V
------
K
D
-------
G
Y
Q
-
M
A
Q
P
A
F
A
P
K
N
I
Y
S
I
M
Q
A
C
W
A
L
E
P
T
H
R
P
T
F
Q
Q
I
C
S
F
L
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
115
Blastp_CBE
63.53
38%
-42
- C2 -
-
6HP9
1
B:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDL---------------
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
--------------
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
63.49
40%
-38
- C2 -
-
6Q7C
1
?
A:
[5-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
--
F
G
E
V
Y
K
G
M
L
-
K
---
T
------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
-----------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
63.48
44%
-107
- C2 -
-
6NPT
1
A:
[25-293]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
-----
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
--------
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
T
-
D
--
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
209
Blastp_CBE
63.36
40%
-30
- C2 -
-
6FNH
6
EPHA2_HUMAN
B:
[8-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
---------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
63.28
44%
-98
- C2 -
-
5WR7
1
A:
[27-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-
E
A
S
-
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
T
-
D
--
Y
Y
R
V
G
G
--
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
Blastp_CBE
63.12
38%
-30
- C2 -
-
6GWR
8
B:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVS--------------
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
A
A-----------
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
62.69
40%
-29
- C2 -
-
5NKH
1
A:
[7-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
---
S
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
Blastp_CBE
62.58
44%
-102
- C2 -
-
6PL1
1
?
A:
[31-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---
L
-----------
L
---
P
E
Q
D
K
M
L
----
V
--
A
V
K
A
L
K
-----
E
S
A
-
R
-
Q
D
F
Q
R
E
A
E
L
L
T
M
L
-
Q
H
Q
H
I
V
R
F
F
G
V
C
T
E
G
R
P
L
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
-----
R
S
H
G
P
D
A
K
L
--
L
A
G
G
E
D
-
V
A
P
G
-
P
L
G
L
G
----
Q
L
---
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
Q
G
L
V
V
K
I
G
D
F
G
M
--
S
R
D
I
Y
---
T
-
D
--
Y
Y
R
V
G
---
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
-
G
K
Q
P
W
Y
Q
-
L
S
N
T
E
A
I
----
D
C
I
------
T
Q
-------
G
R
E
-
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
62.55
40%
-23
- C2 -
-
5IA2
3
A:
[5-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
560
HHSearch
62.42
35%
-26
- C2 -
-
5A46
2
B:
[35-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
---
E
L
P
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
---
L
------------D--
K
P
N
R
V
T
K
----
V
--
A
V
K
M
L
K
-
S
D
A
-
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
-----------
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
62.36
39%
-21
- C2 -
-
5FDX
6
DDR1_HUMAN
A:
[32-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
-----------
Q
DLV-------HPLL
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
---------------
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
62.30
38%
-28
- C2 -
-
4J98
1
FGFR2_HUMAN
B:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
M
E
--
Y
S
Y
D
I
N
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
Q
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
62.26
40%
-30
- C2 -
-
6Q7B
1
?
A:
[5-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
-----------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
62.25
40%
-32
- C2 -
-
5NK4
2
A:
[7-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
------------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
62.20
40%
-29
- C2 -
-
5IA0
11
EPHA2_HUMAN
B:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
62.18
40%
-31
- C2 -
-
6HEY
1
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
-------
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
62.16
38%
-30
- C2 -
-
4J96
1
FGFR2_HUMAN
B:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
M
E
--
Y
S
Y
D
I
N
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
62.10
40%
-31
- C2 -
-
5NK0
1
A:
[8-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
---
S
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
62.04
40%
-26
- C2 -
-
1MQB
1
B:
[35-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
---------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
62.03
39%
-7
- C2 -
-
6FIN
1
A:
[16-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVSPLN---
V
---
R
K
G
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
--------
S
A
H
Q
L
E
--
D
K
A
A
------
P
-
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
62.01
39%
-43
- C2 -
-
5FDX
5
B:
[32-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
--------------------------PLL-
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
A
------------
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
61.93
40%
-29
- C2 -
-
5IA3
1
A:
[8-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
--------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
61.90
40%
-29
- C2 -
-
5NKD
2
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
------------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
61.86
39%
3
- C2 -
-
6FIO
1
A:
[16-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVSLDFPLN
V
---
R
K
G
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
--------
S
A
H
Q
L
E
--
D
K
A
A
E
G
A
--
D
P
-
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
61.82
40%
-27
- C2 -
-
6FNH
11
EPHA2_HUMAN
A:
[8-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
---------------
S
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
D------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
61.79
38%
-33
- C2 -
-
5UI0
1
B:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
M
E
--
Y
S
Y
D
I
N
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
61.71
40%
-28
- C2 -
-
6Q7D
1
?
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
61.60
40%
-28
- C2 -
-
6HEV
1
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
---------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
61.59
38%
-25
- C2 -
-
5UGX
1
FGFR2_HUMAN
A:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
M
E
--
Y
S
Y
D
I
N
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
V
I
N
---
N
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
61.57
38%
-58
- C2 -
-
3BU5
1
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
---
G
M
V
Y
E
G
N
A
R
D
---
I
-----------
I
---
K
G
E
A
E
T
R
----
V
--
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
A
E
------------
N
N
-
P
G
R
P
P
PTLQ
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
-----
E
--
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
K
F
V
------
M
D
-------
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
121
Blastp_CBE
61.57
38%
-13
- C2 -
-
4BKJ
10
DDR1_HUMAN
A:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVSLDFPLN
V
---
R
K
G
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
---------------P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
61.52
40%
-24
- C2 -
-
5NK7
1
A:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
61.48
39%
-23
- C2 -
-
5FDP
7
A:
[32-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
-----------
Q
D---------HPLL
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
A
A-----------
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
61.44
40%
-19
- C2 -
-
5I9Y
4
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
---------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
61.44
40%
-24
- C2 -
-
5NK2
2
A:
[5-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
61.36
40%
-28
- C2 -
-
5NJZ
1
A:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
---------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
61.33
38%
-52
- C2 -
-
1RQQ
1
B:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
---
I
-----------
I
---
K
G
E
A
E
T
R
----
V
--
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
A
E
------------
N
N
-
P
G
R
P
P
PTLQ
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
-----
E
--
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
K
F
V
------
M
D
-------
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
61.33
40%
-26
- C2 -
-
5NK1
1
A:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
61.29
40%
-35
- C2 -
-
6FNF
1
A:
[12-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------T--
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
61.23
40%
0
- C2 -
-
5NKE
1
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
---
S
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
Blastp_CBE
61.16
38%
-10
- C2 -
-
6HP9
1
DDR1_HUMAN
A:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVSLDFPLN
V
---
R
K
G
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
--------------
Q
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
Blastp_CBE
61.15
38%
-5
- C2 -
-
3ZOS
4
DDR1_HUMAN
A:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVSLDFPLN
V
---
R
K
G
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
-----------
A
A
Q
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
61.12
37%
-98
- C2 -
-
2J0L
1
A:
[6-266]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
Q
R
E
R
I
E
L
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I
Y
M
----------------
S
---
P
E
N
P
A
M
A
----
V
--
A
I
K
T
C
K
-
N
C
T
-
S
D
S
V
R
-
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
E
N
-
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
-----
Q
V
R
-----------------
K
F
-
S
L
D
L
A
----
S
L
---
I
L
Y
A
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
--
S
R
--
Y
---
M
E
D
--
S
T
K
A
-
S
K
G
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
-
H
-
G
V
K
P
F
Q
G
-
V
K
N
N
D
V
I
----
G
R
I
------
E
N
-------
G
E
R
-
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
L
K
A
Q
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
Blastp_CBE
61.11
38%
-1
- C2 -
-
3ZOS
3
B:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVSLDFPLN
V
---
R
K
G
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
------------
Q
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
61.09
38%
-52
- C2 -
-
1IR3
1
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
---
I
-----------
I
---
K
G
E
A
E
T
R
----
V
--
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
A
E
------------
N
N
-
P
G
R
P
P
PTLQ
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
-----
E
--
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
K
F
V
------
M
D
-------
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
61.07
40%
-27
- C2 -
-
5I9X
5
A:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-------------------
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
----
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
61.04
40%
-28
- C2 -
-
6Q7G
1
?
A:
[7-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
119
Blastp_CBE
61.00
38%
-10
- C2 -
-
4CKR
6
A:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVSLDFPLN
V
---
R
K
G
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
---------------P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
----
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
Blastp_CBE
60.96
38%
6
- C2 -
-
6GWR
12
DDR1_HUMAN
A:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVSLDFPL-------
G
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
A
AE---------
Q
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
60.95
40%
-27
- C2 -
-
5IA0
7
EPHA2_HUMAN
A:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
-------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
60.91
38%
-33
- C2 -
-
5UHN
1
FGFR2_HUMAN
A:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
----------------
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
369
Blastp_CBE
60.89
37%
-28
- C2 -
-
5EG3
1
A:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
---------
N
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
F
F
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
207
Blastp_CBE
60.87
40%
-26
- C2 -
-
6HES
1
A:
[5-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
60.84
38%
-23
- C2 -
-
2PVY
1
?
A:
[37-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
M
------
D
I
N
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
60.75
40%
-19
- C2 -
-
5NKC
2
A:
[7-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
-----
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
60.69
38%
-54
- C2 -
-
1GAG
1
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
---
I
-----------
I
---
K
G
E
A
E
T
R
----
V
--
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
A
E
------------
N
N
-
P
G
R
P
P
PTLQ
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
-----
E
--
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
K
F
V
------
M
D
-------
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
60.67
40%
-24
- C2 -
-
6FNG
6
A:
[5-277]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
---------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
60.60
40%
-29
- C2 -
-
6HEU
1
A:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
120
Blastp_CBE
60.50
38%
-6
- C2 -
-
4BKJ
10
B:
[10-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVSLDFPLN
V
---
R
K
G
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
-----
S
A
H
Q
L
E
D
K
-------------
G
P
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
----
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
60.49
40%
-33
- C2 -
-
5NKI
1
A:
[10-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
60.41
38%
-31
- C2 -
-
4J97
1
?
D:
[39-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
-
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
-----------
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
60.32
38%
-32
- C2 -
-
4J99
1
B:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
M
E
--
Y
S
Y
D
--------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
60.20
39%
-4
- C2 -
-
6FEX
2
A:
[16-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---
P
QDLVFPLN---
V
---
R
K
G
H
P
L
L
----
V
--
A
V
K
I
L
R
-
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
--------
S
A
H
Q
L
E
-----------
D
P
-
T
I
S
Y
P
----
M
L
---
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
--
S
R
N
L
Y
---
A
G
D
--
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
-
L
C
R
A
Q
P
F
G
Q
-
L
T
D
E
Q
V
I
ENAG
E
F
F
------
R
D
QG-----
R
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
60.18
38%
-52
- C2 -
-
1RQQ
1
INSR_HUMAN
A:
[13-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
S
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
---
I
-----------
I
---
K
G
E
A
E
T
R
----
V
--
A
V
K
T
V
N
-
E
S
A
-
S
L
R
E
R
-
I
E
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
-----
R
S
L
R
P
E
A
E
------------
N
N
-
P
G
R
P
P
PTLQ
E
M
---
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
--
T
R
D
I
Y
-----
E
--
T
D
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
-
A
E
Q
P
Y
Q
G
-
L
S
N
E
Q
V
L
----
K
F
V
------
M
D
-------
G
G
Y
-
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
60.18
40%
-29
- C2 -
-
6Q7E
1
?
A:
[7-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-------------------
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
60.15
40%
3
- C2 -
-
5NKG
1
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
---
S
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
60.13
40%
-2
- C2 -
-
5NK5
1
A:
[11-278]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
---
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
---
S
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
T
-
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
60.05
40%
4
- C2 -
-
5NKF
1
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
---------------
S
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
60.04
40%
-19
- C2 -
-
5NK3
2
A:
[7-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
---
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
208
Blastp_CBE
60.03
40%
-25
- C2 -
-
6FNH
5
C:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
----------------
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
60.00
38%
-49
- C2 -
-
4RWL
1
B:
[36-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LD-----------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
---------------
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
59.92
40%
-27
- C2 -
-
5IA0
7
C:
[6-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
K
FTT
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
----------------
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
---
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
----------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
59.88
38%
-35
- C2 -
-
4J95
1
?
B:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
------------------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
59.60
38%
-34
- C2 -
-
4J95
1
?
C:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
-------------------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
59.52
38%
-30
- C2 -
-
4J97
1
FGFR2_HUMAN
A:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
M
A
E
A
V
G
---
I
----------------
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
------------
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
59.46
40%
2
- C2 -
-
5IA5
3
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
333
Blastp_CBE
59.43
38%
-31
- C2 -
-
4J95
1
FGFR2_HUMAN
A:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
------------------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
---------
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
59.36
38%
-36
- C2 -
-
2PY3
1
B:
[39-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
-------------
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
59.34
38%
-23
- C2 -
-
5VND
10
FGFR1_HUMAN
A:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
E
--
Y
S
Y
N
P
S
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
-
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
59.30
38%
-41
- C2 -
-
4J99
1
?
D:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
-------------------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
T
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
59.25
38%
-38
- C2 -
-
4J95
2
?
D:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
-------------------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
59.20
38%
-35
- C2 -
-
5UGL
1
A:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
--------------
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
V
I
N
---
N
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
58.99
40%
9
- C2 -
-
5I9V
1
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
---
S
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
---------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
58.93
40%
9
- C2 -
-
5NKA
2
A:
[11-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
---
S
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
----------------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
58.92
38%
-42
- C2 -
-
5UHN
2
B:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
-------------------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
58.73
38%
-23
- C2 -
-
3JS2
1
FGFR1_HUMAN
A:
[36-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
---------
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
58.69
40%
1
- C2 -
-
5I9W
3
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
------------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
------------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
58.67
38%
-27
- C2 -
-
2PVY
1
?
B:
[37-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
-------
D
I
N
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
----
Y
Y
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
58.63
38%
-14
- C2 -
-
4UWB
4
FGFR1_HUMAN
A:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
E
--
Y
S
--
P
S
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
-
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
58.62
38%
-33
- C2 -
-
4J99
1
FGFR2_HUMAN
A:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
------------------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
-----
D
--
Y
Y
K
--
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
58.61
40%
11
- C2 -
-
5NK9
1
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
T
--
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
58.54
38%
-40
- C2 -
-
5O49
1
B:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LD-----------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
--------------
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
----------
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
58.49
38%
-27
- C2 -
-
4UWC
9
FGFR1_HUMAN
A:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
E
--
Y
S
Y
-
P
S
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
58.43
38%
-28
- C2 -
-
4V04
6
FGFR1_HUMAN
A:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
E
--
Y
S
--
P
S
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
-------------
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
58.29
38%
-40
- C2 -
-
2PZR
1
B:
[37-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
--------------
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
R
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
58.24
40%
9
- C2 -
-
5IA4
1
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
T
S
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
58.22
38%
-33
- C2 -
-
3B2T
1
FGFR2_HUMAN
A:
[30-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
------
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
-----------------
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
58.12
38%
-21
- C2 -
-
5EW8
1
FGFR1_HUMAN
A:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
-------------
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
58.09
38%
-37
- C2 -
-
6ITJ
1
?
B:
[27-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
E
--
Y
S
Y
-----
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
--------
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
58.05
38%
-29
- C2 -
-
5B7V
1
FGFR1_HUMAN
A:
[25-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
-------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
------
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
57.99
40%
3
- C2 -
-
5NK6
1
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
---
G
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
57.80
38%
-31
- C2 -
-
6NVL
1
FGFR1_HUMAN
A:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
-----------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
---------------
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
57.71
38%
-26
- C2 -
-
4J97
1
B:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
--------
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
--------
I
N
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
57.68
39%
-56
- C2 -
-
4UEU
1
?
A:
[7-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
----------------------
R
N
Y
N
I
E
----
V
--
A
V
K
T
L
K
-----
E
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
-----
R
D
C
E
G
H
T
-----------------
V
N
A
Q
----
A
L
---
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
V
V
K
V
A
D
F
G
L
--
A
R
L
I
----------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
-
Y
-
G
Q
V
P
Y
P
G
-
M
S
G
S
E
V
I
----
E
Q
V
------
E
R
-------
G
Y
R
-
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
220
Blastp_CBE
57.53
40%
13
- C2 -
-
5NKB
3
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
R
V
L
E
DDP
E
A
T
--
Y
T
T
--
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
57.52
40%
8
- C2 -
-
1MQB
1
EPHA2_HUMAN
A:
[38-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-----------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
---------------------
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
57.46
39%
-60
- C2 -
-
4CSV
1
?
A:
[7-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
I
P
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
----------------------
R
N
Y
N
I
E
----
V
--
A
V
K
T
L
K
-----
E
G
T
M
S
V
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
-----
R
D
C
---------------------
V
N
A
Q
----
A
L
---
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
V
V
K
V
A
D
F
G
-------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
-
Y
-
G
Q
V
P
Y
P
G
-
M
S
G
S
E
V
I
----
E
Q
V
------
E
R
-------
G
Y
R
-
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
203
Blastp_CBE
57.42
40%
10
- C2 -
-
6HEW
1
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
-----------------
G
K
--
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
57.31
38%
-36
- C2 -
-
2PWL
1
FGFR2_HUMAN
B:
[43-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
--------------
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
57.13
38%
-15
- C2 -
-
5A46
2
B:
[48-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L--
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
-----------
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
448
Blastp_CBE
57.12
38%
-16
- C2 -
-
5AM6
1
FGFR1_HUMAN
A:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
-------------
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
57.07
38%
-19
- C2 -
-
3JS2
1
B:
[36-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
---------------
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
57.05
40%
5
- C2 -
-
5IA1
2
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
------------------------
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
--
S
---------------------
I
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
57.03
40%
8
- C2 -
-
6HET
1
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-------------------
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
57.02
38%
-37
- C2 -
-
1OEC
1
A:
[35-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------------
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
-----------------
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
196
Blastp_CBE
56.94
40%
5
- C2 -
-
6Q7F
1
?
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-
K
---
T
-------------------
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
56.92
38%
-41
- C2 -
-
5UGL
1
?
B:
[43-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
-------------------
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
V
I
----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
56.89
38%
-19
- C2 -
-
1FGI
1
FGFR1_HUMAN
A:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L------------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
56.88
40%
9
- C2 -
-
6HEX
1
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
A
G
E
F
G
E
V
Y
K
G
M
L
-----------------------
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
L
-------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
56.78
38%
-25
- C2 -
-
6C19
1
FGFR1_HUMAN
A:
[26-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
--
E
--
Y
S
Y
N
P
S
---
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
56.76
38%
-19
- C2 -
-
6MZW
1
FGFR1_HUMAN
A:
[30-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
E
--
Y
S
Y
N
P
S
--
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
56.66
38%
-27
- C2 -
-
3C4F
1
FGFR1_HUMAN
A:
[21-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
56.64
38%
-15
- C2 -
-
2FGI
1
FGFR1_HUMAN
A:
[25-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
-
A
F
G
Q
V
V
L
A
E
A
I
G
L------------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
-----------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
-
D
I
H
---
H
I
D
--
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
487
Blastp_CBE
56.55
38%
-29
- C2 -
-
3GQL
1
FGFR1_HUMAN
B:
[36-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
-------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
---------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
56.52
38%
-19
- C2 -
-
3RHX
4
FGFR1_HUMAN
A:
[25-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
56.37
38%
-23
- C2 -
-
6C18
1
FGFR1_HUMAN
A:
[26-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
-----
S
Y
N
P
S
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
56.34
40%
7
- C2 -
-
5NK8
1
A:
[11-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TT-
E
I
H
P
S
C
V
T
R
Q
K
V
I
G
----
G
E
V
Y
K
G
M
L
-
K
---
T
-----------
S
---
S
G
K
K
E
V
P
----
V
--
A
I
K
T
L
K
-
A
G
Y
-
T
E
K
Q
R
-
V
D
F
L
G
E
A
G
I
M
G
Q
F
-
S
H
H
N
I
I
R
L
E
G
V
I
S
K
Y
K
P
M
M
I
I
T
E
Y
M
E
N
G
A
L
D
K
F
L
----------------------
R
E
K
D
G
-
E
F
S
V
L
----
Q
L
---
V
G
M
L
R
G
I
A
A
G
M
K
Y
L
A
N
M
N
Y
V
H
R
D
L
A
A
R
N
I
L
V
N
---
S
N
L
V
C
K
V
S
D
F
G
--------------------------
P
I
R
W
T
A
P
E
A
I
S
Y
R
K
F
T
S
A
S
D
V
W
S
F
G
I
V
M
W
E
V
M
T
-
Y
-
G
E
R
P
Y
W
E
-
L
S
N
H
E
V
M
----
K
A
I
------
N
D
-------
G
F
R
-
L
P
T
P
M
D
C
P
S
A
I
Y
Q
L
M
M
Q
C
W
Q
Q
E
R
A
R
R
P
K
F
A
D
I
V
S
I
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
398
Blastp_CBE
56.32
38%
-19
- C2 -
-
5O4A
2
FGFR1_HUMAN
A:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
-------------
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
56.29
38%
-16
- C2 -
-
5A46
4
FGFR1_HUMAN
A:
[48-314]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
------------
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
------
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
56.29
38%
-22
- C2 -
-
6ITJ
1
?
A:
[27-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
56.25
38%
-19
- C2 -
-
1FGI
1
B:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L------------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
-------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
---------
D
--
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
56.18
38%
-14
- C2 -
-
4UWC
9
B:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L--
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
E
--
Y
S
Y
---
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
55.95
38%
-36
- C2 -
-
2PWL
1
FGFR2_HUMAN
A:
[43-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
D
K
P
K
E
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
H
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
----------------
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
55.82
38%
-19
- C2 -
-
4F63
3
FGFR1_HUMAN
A:
[24-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
-
A
F
G
Q
V
V
L
A
E
A
I
G
L------------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
55.80
38%
-29
- C2 -
-
4ZSA
1
B:
[27-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
55.76
38%
-20
- C2 -
-
5O49
1
FGFR1_HUMAN
A:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
55.64
38%
-24
- C2 -
-
3C4F
1
B:
[21-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
55.63
38%
-15
- C2 -
-
5O4A
1
B:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L--
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
E
--
Y
S
Y
------
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
----------
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
55.55
38%
-19
- C2 -
-
4F64
3
FGFR1_HUMAN
A:
[24-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
-
A
F
G
Q
V
V
L
A
E
A
I
G
L------------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
55.51
38%
-43
- C2 -
-
4F65
4
B:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LD-----------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
------------
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
55.34
38%
-16
- C2 -
-
5Z0S
1
FGFR1_HUMAN
A:
[27-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L--
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
113
Blastp_CBE
55.32
40%
-55
- C2 -
-
5XFF
1
A:
[31-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
MD-
P
-----------
A
---
R
P
D
Q
A
S
T
----
V
--
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
-
D
L
V
S
E
M
E
V
M
K
L
I
G
-
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
-----
R
A
R
R
P
P
G
P
---------------
P
L
S
F
P
----
V
L
---
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
S
L
L
------
R
E
-------
G
H
R
-
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
55.29
38%
-15
- C2 -
-
4F64
3
B:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L------------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
-------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
---------
D
--
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
55.21
38%
-10
- C2 -
-
3RHX
2
B:
[25-291]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L------------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
-------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
---------
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
55.21
38%
-23
- C2 -
-
6C1C
1
FGFR1_HUMAN
A:
[30-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
------
S
Y
N
P
S
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
55.12
38%
-10
- C2 -
-
4UWB
3
B:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L--
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
E
--
Y
S
Y
---
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
------
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
55.11
38%
-26
- C2 -
-
5UR1
1
FGFR1_HUMAN
A:
[30-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
-
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
-------
Y
N
P
S
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
55.01
38%
-21
- C2 -
-
6MZQ
1
FGFR1_HUMAN
A:
[30-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
E
--
Y
S
Y
N
P
S
---
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
54.98
38%
-17
- C2 -
-
5Z0S
1
B:
[27-293]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L------------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
-
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
54.74
38%
-9
- C2 -
-
3TT0
1
FGFR1_HUMAN
A:
[77-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
G
L
E
--
Y
S
Y
N
P
S
H
N
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
H
---
H
I
D
--
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
54.55
38%
-25
- C2 -
-
3GQL
1
C:
[36-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
---------------
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
---------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
54.50
38%
-20
- C2 -
-
5AM6
1
B:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
--------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
------------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
54.45
38%
-17
- C2 -
-
4F65
5
FGFR1_HUMAN
A:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L--
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
-------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
-----------------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
54.33
38%
-61
- C2 -
-
6C1B
1
B:
[30-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
L
A
E
A
I
----------------------
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
-------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
54.22
38%
-23
- C2 -
-
3GQL
1
FGFR1_HUMAN
A:
[36-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
P
---------------
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
-----------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
54.11
38%
-9
- C2 -
-
5B7V
1
B:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L--
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
---------------
P
E
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
R
--------
D
--
Y
Y
K
K
T
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
53.99
38%
-28
- C2 -
-
6MZQ
1
B:
[30-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
---------------------
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
--------------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
53.74
38%
-12
- C2 -
-
1AGW
1
B:
[29-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L------------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
-------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
---------
D
--
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
53.38
38%
-28
- C2 -
-
3TT0
4
B:
[77-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
-------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
----------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
52.54
38%
-33
- C2 -
-
6C19
1
B:
[30-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
LDK
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
-----------------
E
-
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
52.40
38%
-8
- C2 -
-
4F63
3
B:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L------------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
-------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
---------
D
--
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
52.15
38%
-9
- C2 -
-
5UQ0
1
B:
[30-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L--------------------
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
-------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------------------------
L
P
V
K
W
M
A
P
E
A
L
--
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
134
Blastp_CBE
52.11
40%
-21
- C2 -
-
5XFJ
1
A:
[31-297]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
MD-
P
-----------
A
---
R
P
D
Q
A
S
T
----
V
--
A
V
K
M
L
K
-
D
---
D
K
D
L
A
-
D
L
V
S
E
M
E
V
M
K
L
I
G
-
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
E
G
P
L
Y
V
I
M
E
C
A
A
K
G
N
L
R
E
F
L
-----
R
A
R
R
P
P
G
P
---------------
P
L
S
F
P
----
V
L
---
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
S
L
L
------
R
E
-------
G
H
R
-
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
51.70
38%
-11
- C2 -
-
4NKS
1
B:
[28-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L------------------
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
-------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
---------
D
--
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
51.09
38%
-14
- C2 -
-
5UR1
1
B:
[30-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L--
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
50.57
38%
-19
- C2 -
-
6C1C
1
B:
[30-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
-
F
G
Q
V
V
L
A
E
A
I
G
L--
D
-----------
K
---
P
N
R
V
T
K
-----
V
--
A
V
K
M
L
K
S
D
A
T
-
E
K
D
L
S
-
D
L
I
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
Q
A
R
R
P
------------------
Q
L
S
S
K
----
D
L
---
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--
A
---------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
V
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
50.22
38%
-18
- C2 -
-
4J97
1
?
C:
[39-313]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
---
I
-----------
D
---
K
-----
A
----
V
TV
A
V
K
M
L
K
-
D
D
A
T
E
K
D
L
S
-
D
L
V
S
E
M
E
M
M
K
M
I
G
-
K
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
-----
R
A
R
R
P
P
G
---------
N
R
V
P
E
E
-
Q
M
T
F
K
----
D
L
---
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
--
A
R
D
I
N
---
N
I
D
--
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
-
G
G
S
P
Y
P
G
-
I
P
V
E
E
L
F
----
K
L
L
------
K
E
-------
G
H
R
-
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------