@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ROS1_HUMAN: (2020-09-20 )
MKNIYCLIPKLVNFATLGCLWISVVQCTVLNSCLKSCVTNLGQQLDLGTPHNLSEPCIQGCHFWNSVDQKNCALKCRESCEVGCSSAEGAYEEEVLENADLPTAPFASSIGSHNMTLRWKSANFSGVKYIIQWKYAQLLGSWTYTKTVSRPSYVVKPLHPFTEYIFRVVWIFTAQLQLYSPPSPSYRTHPHGVPETAPLIRNIESSSPDTVEVSWDPPQFPGGPILGYNLRLISKNQKLDAGTQRTSFQFYSTLPNTIYRFSIAAVNEVGEGPEAESSITTSSSAVQQEEQWLFLSRKTSLRKRSLKHLVDEAHCLRLDAIYHNITGISVDVHQQIVYFSEGTLIWAKKAANMSDVSDLRIFYRGSGLISSISIDWLYQRMYFIMDELVCVCDLENCSNIEEITPPSISAPQKIVADSYNGYVFYLLRDGIYRADLPVPSGRCAEAVRIVESCTLKDFAIKPQAKRIIYFNDTAQVFMSTFLDGSASHLILPRIPFADVKSFACENNDFLVTDGKVIFQQDALSFNEFIVGCDLSHIEEFGFGNLVIFGSSSQLHPLPGRPQELSVLFGSHQALVQWKPPALAIGANVILISDIIELFELGPSAWQNWTYEVKVSTQDPPEVTHIFLNISGTMLNVPELQSAMKYKVSVRASSPKRPGPWSEPSVGTTLVPASEPPFIMAVKEDGLWSKPLNSFGPGEFLSSDIGNVSDMDWYNNSLYYSDTKGDVFVWLLNGTDISENYHLPSIAGAGALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMVVDSVGGYLYWTTLYSVESTRLNGESSLVLQTQPWFSGKKVIALTLDLSDGLLYWLVQDSQCIHLYTAVLRGQSTGDTTITEFAAWSTSEISQNALMYYSGRLFWINGFRIITTQEIGQKTSVSVLEPARFNQFTIIQTSLKPLPGNFSFTPKVIPDSVQESSFRIEGNASSFQILWNGPPAVDWGVVFYSVEFSAHSKFLASEQHSLPVFTVEGLEPYALFNLSVTPYTYWGKGPKTSLSLRAPETVPSAPENPRIFILPSGKCCNKNEVVVEFRWNKPKHENGVLTKFEIFYNISNQSITNKTCEDWIAVNVTPSVMSFQLEGMSPRCFIAFQVRAFTSKGPGPYADVVKSTTSEINPFPHLITLLGNKIVFLDMDQNQVVWTFSAERVISAVCYTADNEMGYYAEGDSLFLLHLHNRSSSELFQDSLVFDITVITIDWISRHLYFALKESQNGMQVFDVDLEHKVKYPREVKIHNRNSTIISFSVYPLLSRLYWTEVSNFGYQMFYYSIISHTLHRILQPTATNQQNKRNQCSCNVTEFELSGAMAIDTSNLEKPLIYFAKAQEIWAMDLEGCQCWRVITVPAMLAGKTLVSLTVDGDLIYWIITAKDSTQIYQAKKGNGAIVSQVKALRSRHILAYSSVMQPFPDKAFLSLASDTVEPTILNATNTSLTIRLPLAKTNLTWYGITSPTPTYLVYYAEVNDRKNSSDLKYRILEFQDSIALIEDLQPFSTYMIQIAVKNYYSDPLEHLPPGKEIWGKTKNGVPEAVQLINTTVRSDTSLIISWRESHKPNGPKESVRYQLAISHLALIPETPLRQSEFPNGRLTLLVTRLSGGNIYVLKVLACHSEEMWCTESHPVTVEMFNTPEKPYSLVPENTSLQFNWKAPLNVNLIRFWVELQKWKYNEFYHVKTSCSQGPAYVCNITNLQPYTSYNVRVVVVYKTGENSTSLPESFKTKAGVPNKPGIPKLLEGSKNSIQWEKAEDNGCRITYYILEIRKSTSNNLQNQNLRWKMTFNGSCSSVCTWKSKNLKGIFQFRVVAANNLGFGEYSGISENIILVGDDFWIPETSFILTIIVGIFLVVTIPLTFVWHRRLKNQKSAKEGVTVLINEDKELAELRGLAAGVGLANACYAIHTLPTQEEIENLPAFPREKLTLRLLLGSGAFGEVYEGTAVDILGVGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLNEPQYIILELMEGGDLLTYLRKARMATFYGPLLTLVDLVDLCVDISKGCVYLERMHFIHRDLAARNCLVSVKDYTSPRIVKIGDFGLARDIYKNDYYRKRGEGLLPVRWMAPESLMDGIFTTQSDVWSFGILIWEILTLGHQPYPAHSNLDVLNYVQTGGRLEPPRNCPDDLWNLMTQCWAQEPDQRPTFHRIQDQLQLFRNFFLNSIYKSRDEANNSGVINESFEGEDGDVICLNSDDIMPVALMETKNREGLNYMVLATECGQGEEKSEGPLGSQESESCGLRKEEKEPHADKDFCQEKQVAYCPSGKPEGLNYACLTHSGYGDGSD
Atome Classification :
(473 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270......1280......1290......1300......1310......1320......1330......1340......1350......1360......1370......1380......1390......1400......1410......1420......1430......1440......1450......1460......1470......1480......1490......1500......1510......1520......1530......1540......1550......1560......1570......1580......1590......1600......1610......1620......1630......1640......1650......1660......1670......1680......1690......1700......1710......1720......1730......1740......1750......1760......1770......1780......1790......1800......1810......1820......1830......1840......1850...----...1860....-..1870......1880......1890......1900......1910......1920......1930......1940---........1950......1960....-..-1970.-.-.-...1980......1990-......2000.-.-....2010....-..2020----.......2030......2040--..-------.-.----------.---------..-----.------.------2050----.---....------....2060......2070......2080......2090......2100....-..2110......2120......2130......2140......2150...-...2160...-...2170...-------...2180......2190......2200......2210......2220......2230......2240......2250......2260......2270......2280......2290......2300......2310......2320......2330......2340....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MK
N
I
Y
C
L
I
P
K
L
V
N
F
A
T
L
G
C
L
W
I
S
V
V
Q
C
T
V
L
N
S
C
L
K
S
C
V
T
N
L
GQQLDLGTPHNL
S
E
P
C
I
Q
G
C
HFWNSVDQK
N
C
A
L
K
C
R
E
S
CEVGCSSAEG
A
Y
E
E
E
V
L
ENADLPTA
P
F
A
S
SIGSH
N
M
T
L
R
W
KSANFS
G
V
K
Y
I
I
Q
W
K
Y
A
Q
L
LGSWT
Y
T
K
TVSRPS
Y
V
VKPL
H
P
F
T
E
Y
I
F
R
V
V
W
I
F
T
A
Q
L
Q
L
YSPPSPSYRTHPHGVP
E
T
A
P
L
I
R
NIESSSP
D
T
V
E
V
SWDPPQFPGG
P
I
L
G
Y
N
L
R
L
I
SKNQKLDAGTQR
T
S
F
Q
F
YSTLPN
T
I
Y
R
F
S
I
A
A
V
N
EVGEGPEAESSITTS
S
S
A
V
Q
QEE
Q
W
L
F
LSRKT
S
L
R
K
R
S
L
K
H
L
V
D
E
A
H
C
L
R
L
D
A
I
Y
HNITG
I
S
V
D
V
H
Q
Q
I
V
Y
FSE
G
T
L
I
W
A
KKAANMSDVS
D
L
R
I
F
Y
RGSGL
I
S
S
I
S
I
D
W
L
Y
Q
R
M
Y
F
I
M
D
E
L
V
C
V
CDLENCSN
I
E
EITPPSISA
P
Q
K
I
V
ADSYN
G
Y
V
F
Y
L
LRDGIYRADLPVPS
G
R
C
A
E
A
V
R
I
V
E
SCTLKDFAIKPQA
K
R
I
I
Y
FN
D
T
A
Q
V
F
M
S
T
F
LDGSAS
H
L
ILPRI
P
F
A
D
V
K
S
FACENN
D
F
L
VTD
G
K
V
I
F
QQDAL
S
F
N
E
F
I
VGC
D
L
S
H
I
E
E
FGFG
N
L
V
I
FGSSSQLHPLPGR
P
Q
E
L
S
V
LFGS
H
Q
A
L
V
Q
WKPP
A
L
A
IG
A
N
V
I
L
I
S
D
I
I
E
L
F
ELG
P
S
A
WQ
N
W
T
Y
E
V
K
VSTQDPP
E
V
T
H
I
F
L
NISG
T
M
L
N
V
P
E
L
Q
S
A
M
K
Y
K
V
S
V
R
ASSPKRPGPWSEPSVG
T
T
LVPASEP
P
F
I
M
A
V
KEDGLWSKPLNSFG
P
G
E
F
L
S
S
D
IGNVSDMDWYNN
S
L
Y
Y
SDTKG
D
V
F
V
W
L
LNGTDISENYHLPSIAG
A
G
A
L
A
F
E
W
L
G
H
F
L
Y
WAG
K
T
Y
V
I
Q
R
QSVLTG
H
T
D
I
V
T
H
V
K
L
L
V
N
D
M
V
V
DSVG
G
Y
L
Y
W
T
T
L
Y
S
V
E
S
T
RLNGE
S
S
L
V
L
Q
TQPWFSG
K
K
V
I
A
L
T
L
DLSD
G
L
L
Y
W
L
VQDS
Q
C
I
H
L
Y
T
A
V
L
RGQSTGD
T
T
I
T
E
FAAWS
T
S
E
ISQN
A
L
M
Y
YS
G
R
L
F
W
I
N
G
F
R
I
I
T
T
Q
EIGQKTS
V
S
VLEPARF
N
Q
F
T
I
I
QTSLKPLPGNFSFTPKVIPDSVQES
S
F
R
IEGNA
S
S
F
Q
I
L
WNGPPA
V
D
W
G
V
V
F
Y
S
V
E
FSAH
S
K
F
L
ASEQHS
L
P
V
F
T
VEGLE
P
Y
A
L
F
N
L
SVT
P
Y
TYWGKGPKT
S
L
S
LRAPETVPSAPEN
P
R
I
F
I
LPSGKCCNKN
E
V
V
V
E
F
R
WNKPKHENG
V
L
T
K
F
E
I
F
Y
NISNQSITNKTCE
D
W
I
A
V
NVTP
S
V
M
S
F
Q
LEGMSP
R
C
F
I
A
F
Q
V
R
A
FTSKGPG
P
Y
A
D
V
V
K
S
TTSEINP
F
P
H
L
I
T
L
LG
N
K
I
V
F
L
DMDQ
N
Q
V
V
W
T
F
S
A
E
R
V
I
S
A
V
C
YTADNEM
G
Y
Y
AEG
D
S
L
F
L
L
H
LHNR
S
S
S
E
L
FQDS
L
V
F
D
I
T
V
I
T
I
D
W
I
S
R
H
L
Y
F
A
L
KESQNG
M
Q
V
F
DVD
L
E
H
KVKYP
R
E
V
K
I
HNRN
S
T
I
I
S
F
S
V
Y
P
L
L
S
R
L
Y
W
T
E
VSNF
G
Y
Q
M
F
Y
Y
S
I
I
S
H
T
L
H
R
I
LQPTATNQQNKRNQCSCN
V
T
E
F
E
LS
G
A
M
A
IDTSNLEKP
L
I
Y
F
AKA
Q
E
I
W
A
MDLEG
C
Q
C
W
R
V
I
T
V
P
A
M
LAG
K
T
L
V
S
L
T
VDG
D
L
I
Y
W
I
I
TAKDS
T
Q
I
Y
Q
AKKGN
G
A
I
V
S
Q
V
K
A
L
R
S
R
H
I
L
A
Y
S
S
V
MQPFP
D
K
A
F
L
S
L
A
SDTVE
P
T
I
L
NATN
T
S
L
T
I
R
L
PLAKT
N
L
T
W
Y
GITSPT
P
T
Y
L
V
Y
Y
A
E
VNDRKNSSD
L
K
Y
R
I
L
EFQD
S
I
A
L
I
E
DLQ
P
F
S
T
Y
M
I
Q
I
A
V
K
N
YYSD
P
L
E
HLP
P
G
K
E
I
WGKTKNG
V
P
E
A
V
Q
L
I
N
T
T
VRSD
T
S
L
I
I
S
W
R
E
SHKPNG
P
K
E
S
V
R
Y
Q
L
A
I
S
H
L
ALIPETPLRQSEFPNG
R
L
T
L
L
V
T
RLSGG
N
I
Y
V
L
K
V
L
ACHSEEMWCTESH
P
V
T
V
E
MFNTPEK
P
Y
SLVPEN
T
S
L
Q
F
NWKAPL
N
V
N
L
I
R
F
W
V
E
L
Q
KWKYN
E
F
Y
H
V
KTSCSQG
P
A
Y
V
C
NITNLQPYTSY
N
V
R
V
V
V
V
Y
KTGENSTSL
P
E
S
FKTKAGVPNKPGI
P
K
L
LEGSKNS
I
Q
W
EKAEDNG
C
R
I
T
Y
Y
I
L
E
I
RKSTSNNLQNQN
L
R
W
K
M
T
FNGSCS
S
V
C
T
WKSKNL
K
G
I
F
Q
F
R
V
V
A
ANNLGFGEYSGISE
N
I
I
L
VGDDFW----IP
E
T
S
F
I
L
T
I
I
-
V
G
I
F
L
V
V
T
I
P
L
T
F
V
W
H
R
R
LKNQKSAKE
G
V
T
V
L
INE
D
K
E
L
A
E
L
R
G
L
A
AGV
G
L
A
N
A
C
Y
A
IHTLP
T
Q
E
E
I
E
NLPAFP-----RE
K
L
T
L
R
L
L
LGSGAFGEVYEG
T
A
V
D
I
-
L
G-VGSG
E
-
I
-
K
-
V
A
V
K
T
L
KKGST
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
KF-N-
H
P
N
I
L
K
Q
L
G
V
C
L-LNEPQ-----
Y
I
I
L
E
L
MEGG
D
L
L
T
Y
L
R
K
-----
A
R
-------
M
-
A
----------
T
---------
F
Y
-----
G
------
P
------
L
-------
L
---
T
L
V
D
------
L
V
D
L
C
V
D
IS
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
ARN
C
L
V
S
VKDYTS
P
R
I
V
K
IGDF
G
L
A
R
-
D
I
Y
KN
D
Y
Y
R
KRGEGL
L
P
V
R
WM
A
P
E
S
L
M
D
G
I
FTTQ
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
-LGHQPYPAHS-NL
D
V
L
N
Y
V
QT-------GGRLEPPRN
C
P
D
D
L
W
N
L
M
T
Q
C
WAQEPDQRP
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
KSRDEANNSGVINESFEGEDG
D
V
I
C
LNSDD
I
M
P
V
A
L
M
ETKNREG
L
N
Y
M
V
L
A
TECGQGEEKSEGPLGSQ
E
S
E
SCGLRKEEKEPHA
D
K
D
F
C
Q
EK
Q
V
A
YCPSGKPEG
L
N
Y
A
C
L
T
HSGYGDGSD
1
PsiBlast_PDB
87.87
99%
-133
- C4 -
-
3ZBF
1
A:
[24-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
N
L
P
A
F
P
-----
R
E
K
L
T
L
R
L
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
I
-
L
G
-
V
G
S
G
E
-
I
-
K
-
V
A
V
K
T
L
K
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
-
L
N
E
P
Q
-----
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
-----
A
R
-------
M
-
A
----------
T
---------
F
Y
-----
G
------
P
------
L
-------
L
---
T
L
V
D
------
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D
Y
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
-
D
I
Y
------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
-
L
G
H
Q
P
Y
P
A
H
S
-
N
L
D
V
L
N
Y
V
Q
T
-------
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
----------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.80
99%
-130
- C4 -
-
4UXL
1
A:
[24-319]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
N
L
P
A
F
P
-----
R
E
K
L
T
L
R
L
L
L
G
S
G
A
F
G
E
V
Y
E
G
T
A
V
D
I
-
L
G
-
V
G
S
G
E
-
I
-
K
-
V
A
V
K
T
L
K
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
-
L
N
E
P
Q
-----
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
-----
A
R
-------
M
-
A
----------
T
---------
F
Y
-----
G
------
P
------
L
-------
L
---
T
L
V
D
------
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D
Y
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
-
D
I
Y
K
--------
E
G
L
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
-
L
G
H
Q
P
Y
P
A
H
S
-
N
L
D
V
L
N
Y
V
Q
T
-------
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
S
----------------------------------------------------------------------------------------------------------------------
563
HHSearch
87.63
100%
-133
- C4 -
-
3ZBF
1
A:
[25-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
P
A
F
P
-----
R
E
K
L
T
L
R
L
L
L
G
S
---
G
E
V
Y
E
G
T
A
V
D
I
-
L
G
-
V
G
S
G
E
-
I
-
K
-
V
A
V
K
T
L
K
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
-
L
N
E
P
Q
-----
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
-----
A
R
-------
M
-
A
----------
T
---------
F
Y
-----
G
------
P
------
L
-------
L
---
T
L
V
D
------
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D
Y
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
-
D
I
Y
------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
-
L
G
H
Q
P
Y
P
A
H
S
-
N
L
D
V
L
N
Y
V
Q
T
-------
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
-----------------------------------------------------------------------------------------------------------------------
562
HHSearch
87.57
100%
-130
- C4 -
-
4UXL
1
A:
[25-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
P
A
F
P
-----
R
E
K
L
T
L
R
L
L
L
G
S
G
A
F
G
E
V
Y
E
G
T
A
V
D
I
-
L
G
-
V
G
S
G
E
-
I
-
K
-
V
A
V
K
T
L
K
K
G
S
T
D
Q
E
K
I
E
-
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
-
L
N
E
P
Q
-----
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
-----
A
R
-------
M
-
A
----------
T
---------
F
Y
-----
G
------
P
------
L
-------
L
---
T
L
V
D
------
L
V
D
L
C
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
S
V
K
D
Y
T
S
P
R
I
V
K
I
G
D
F
G
L
A
R
-
D
I
Y
K
--------
E
G
L
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
-
L
G
H
Q
P
Y
P
A
H
S
-
N
L
D
V
L
N
Y
V
Q
T
-------
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
H
R
I
Q
D
Q
L
Q
L
F
R
N
F
F
L
N
S
I
Y
K
-----------------------------------------------------------------------------------------------------------------------
40
Blastp_CBE
72.43
48%
-128
- C4 -
-
5AAB
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
--
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
37
Blastp_CBE
72.20
48%
-127
- C4 -
-
5AAA
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
38
Blastp_CBE
72.10
48%
-129
- C4 -
-
5AA9
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
29
Blastp_CBE
71.94
48%
-123
- C4 -
-
4CNH
2
B:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
---------------------------
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
S
Y
-----
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
71.90
48%
-128
- C4 -
-
4CLI
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
30
Blastp_CBE
71.79
48%
-120
- C4 -
-
4TT7
5
A:
[2-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
-
V
S
---------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
---------------------------
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
S
--
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
42
Blastp_CBE
71.74
49%
-129
- C4 -
-
5IUI
1
A:
[22-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G
------
P
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
-----
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
51
Blastp_CBE
71.62
49%
-125
- C4 -
-
4FOB
1
A:
[48-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
--------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
---------------------------
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
31
Blastp_CBE
71.55
48%
-125
- C4 -
-
5AAC
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
71.51
48%
-127
- C4 -
-
4CCU
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
50
Blastp_CBE
71.50
49%
-128
- C4 -
-
4FOC
1
A:
[48-327]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
--------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
71.48
48%
-126
- C4 -
-
4CMO
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
71.46
48%
-126
- C4 -
-
4CMU
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
41
Blastp_CBE
71.38
48%
-128
- C4 -
-
5AA8
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
46
Blastp_CBE
71.29
49%
-127
- C4 -
-
4FOD
2
A:
[28-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
--------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
71.28
48%
-115
- C4 -
-
3LCT
3
A:
[29-318]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G
-
M
P
-
N
D
P
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
71.21
48%
-117
- C4 -
-
3LCS
3
A:
[30-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G
-
M
P
-
N
D
P
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
385
Blastp_CBE
71.17
43%
-141
- C4 -
-
4MXO
1
SRC_HUMAN
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
416
Blastp_CBE
71.15
43%
-129
- C4 -
-
3U4W
4
A:
[4-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
---------
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
D
N
E
Y
T
A
R
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
532
Blastp_CBE
71.05
43%
-147
- C4 -
-
3G5D
2
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
---
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.05
48%
-118
- C4 -
-
3L9P
4
A:
[52-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G
-------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
32
Blastp_CBE
71.02
48%
-124
- C4 -
-
5A9U
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
70.95
48%
-119
- C4 -
-
4MKC
3
A:
[52-341]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
--------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
G
Y
Y
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
21
Blastp_CBE
70.91
48%
-130
- C4 -
-
6MX8
1
A:
[2-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
S
---------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
----------------
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
--------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
70.88
48%
-128
- C4 -
-
4CCB
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
---------------------------
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
39
Blastp_CBE
70.85
48%
-126
- C4 -
-
4CD0
1
A:
[26-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
437
Blastp_CBE
70.61
42%
-127
- C4 -
-
5ZJ6
1
HCK_HUMAN
A:
[24-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
---------
N
K
H
-
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
---
F
L
A
E
A
N
V
M
K
T
L
-
Q
-
H
D
K
L
V
K
-
L
H
A
V
V
-
T
K
E
P
I
-----
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-----
D
E
-------------------------------------
G
------
S
------
K
-------
Q
---
P
L
P
K
------
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-
V
I
E
D
N
E
Y
T
A
R
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
-
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
-------
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---------------------------------------------------------------------------------------------------------------------------------
47
Blastp_CBE
70.59
49%
-133
- C4 -
-
4DCE
1
B:
[28-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
----
E
V
Y
E
G
Q
-
V
S
--------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
35
Blastp_CBE
70.51
48%
-128
- C4 -
-
2YFX
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
435
Blastp_CBE
70.41
42%
-132
- C4 -
-
2HK5
1
HCK_HUMAN
A:
[13-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
---------
N
K
H
-
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
---
F
L
A
E
A
N
V
M
K
T
L
-
Q
-
H
D
K
L
V
K
-
L
H
A
V
V
-
T
K
E
P
I
-----
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-----
D
E
-------------------------------------
G
------
S
------
K
-------
Q
---
P
L
P
K
------
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-
V
I
E
D
N
E
Y
T
A
R
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
-
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
-------
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---------------------------------------------------------------------------------------------------------------------------------
48
Blastp_CBE
70.37
49%
-127
- C4 -
-
4DCE
1
ALK_HUMAN
A:
[28-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
S
-------
P
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
---------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
45
Blastp_CBE
70.35
49%
-128
- C4 -
-
4FNZ
1
A:
[22-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
S
G
-------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
----------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
33
Blastp_CBE
70.27
48%
-121
- C4 -
-
4Z55
3
A:
[24-313]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
--------------------------------------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
G
Y
Y
-
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
34
Blastp_CBE
70.19
48%
-123
- C4 -
-
4CLJ
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
27
Blastp_CBE
70.19
48%
-131
- C4 -
-
6EBW
1
A:
[12-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
C
F
---
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
--
F
G
E
V
Y
E
G
Q
-
V
S
--------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
----------------
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
--------------
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
23
Blastp_CBE
70.15
48%
-127
- C4 -
-
5FTO
1
A:
[3-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
S
G
-
M
-----
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
-------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
49
Blastp_CBE
70.04
48%
-128
- C4 -
-
4ANQ
1
A:
[26-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
A
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
22
Blastp_CBE
69.98
48%
-127
- C4 -
-
5FTQ
2
A:
[3-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
--------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
-
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
69.97
48%
-129
- C4 -
-
4CTB
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
---
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
384
Blastp_CBE
69.90
43%
-137
- C4 -
-
4MXO
1
SRC_HUMAN
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
-------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
52
Blastp_CBE
69.90
48%
-132
- C4 -
-
4ANS
1
A:
[26-315]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
A
D
F
G
M
A
R
-
D
I
Y
R
------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
495
Blastp_CBE
69.88
43%
-145
- C4 -
-
6HVE
1
?
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.83
48%
-129
- C4 -
-
4CMT
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
---------------------------
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
546
Blastp_CBE
69.81
41%
-131
- C4 -
-
2ZV9
1
LYN_MOUSE
A:
[10-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
R
E
S
I
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
--------
M
G
-
Y
Y
N
N
S
-
T
-
K
-
V
A
V
K
T
L
K
P
G
T
M
S
V
Q
A
---
F
L
E
E
A
N
L
M
K
T
L
-
Q
-
H
D
K
L
V
R
L
Y
A
V
V
T
-
K
E
E
P
I
-----
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-----
D
E
-------------------------------------
G
------
G
------
K
-------
V
---
L
L
P
K
------
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
-----
E
S
L
M
C
K
I
A
D
F
G
L
A
R
-
V
I
--------
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
-
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
-------
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
---------------------------------------------------------------------------------------------------------------------------------
558
HHSearch
69.78
45%
-121
- C4 -
-
5FM3
1
A:
[61-350]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
--
G
R
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-----
S
----------------------------------------------------
A
-------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
E
-----
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
K
M
---------------------------------------------------------------------------------------------------------------------------------
43
Blastp_CBE
69.73
49%
-139
- C4 -
-
5IUH
1
A:
[22-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
-----
G
E
V
Y
E
G
Q
-
V
S
G
--------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
---------------------------
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
--------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
69.71
48%
-128
- C4 -
-
3AOX
5
A:
[28-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
-
V
S
---------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
A
-------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
69.70
48%
-122
- C4 -
-
5KZ0
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
28
Blastp_CBE
69.64
48%
-125
- C4 -
-
6E0R
1
A:
[15-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
----
V
Y
E
G
Q
-
V
---------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
-----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
69.64
48%
-128
- C4 -
-
4CTC
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
--------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.64
48%
-129
- C4 -
-
2XP2
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
Q
-
V
----------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
---------------------------
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
485
Blastp_CBE
69.62
43%
-136
- C4 -
-
3DQX
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
--------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
472
Blastp_CBE
69.55
43%
-133
- C4 -
-
3F6X
1
SRC_CHICK
D:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
-----------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
436
Blastp_CBE
69.49
42%
-126
- C4 -
-
5ZJ6
1
HCK_HUMAN
B:
[24-280]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
R
E
S
L
K
L
E
K
K
L
G
A
G
Q
F
G
E
V
W
M
A
T
Y
---------
N
K
H
-
T
-
K
-
V
A
V
K
T
M
K
P
G
S
M
S
V
E
A
---
F
L
A
E
A
N
V
M
K
T
L
-
Q
-
H
D
K
L
V
K
-
L
H
A
V
V
-
T
K
E
P
I
-----
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-----
D
E
-------------------------------------
G
------
S
------
K
-------
Q
---
P
L
P
K
------
L
I
D
F
S
A
Q
I
A
E
G
M
A
F
I
E
Q
R
N
Y
I
H
R
D
L
R
A
A
N
I
L
V
S
-----
A
S
L
V
C
K
I
A
D
F
G
L
A
R
-
V
I
E
D
N
E
Y
T
A
R
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
S
F
T
I
K
S
D
V
W
S
F
G
I
L
L
M
E
I
V
T
-
Y
G
R
I
P
Y
P
G
M
S
-
N
P
E
V
I
R
A
L
E
R
-------
G
Y
R
M
P
R
P
E
N
C
P
E
E
L
Y
N
I
M
M
R
C
W
K
N
R
P
E
E
R
P
T
F
E
Y
I
Q
S
V
L
D
D
F
---------------------------------------------------------------------------------------------------------------------------------
44
Blastp_CBE
69.47
49%
-132
- C4 -
-
5IUG
1
A:
[22-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
----
G
E
V
Y
E
G
Q
-
V
---------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
------------------------------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
-------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
439
Blastp_CBE
69.44
43%
-136
- C4 -
-
5XP7
2
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
26
Blastp_CBE
69.29
48%
-126
- C4 -
-
6EDL
1
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
S
--------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
-----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
484
Blastp_CBE
69.24
43%
-132
- C4 -
-
3DQX
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
-------
Q
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
440
Blastp_CBE
69.24
43%
-140
- C4 -
-
5XP7
2
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
-------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
197
Blastp_CBE
69.11
42%
-118
- C4 -
-
6JMF
1
A:
[112-372]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
--------
L
R
A
D
N
-
T
-
L
-
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
-----
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-----
E
--------------------------------------
G
------
A
------
R
-------
L
---
R
V
K
T
------
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
-
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-------------------------------------------------------------------------------------------------------------------------------
567
HHSearch
69.10
39%
-136
- C4 -
-
2QOC
2
A:
[12-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
D
-----
A
T
N
I
S
I
D
K
V
V
G
A
G
E
F
G
E
V
C
S
G
R
L
K
L
P
-----
S
K
K
E
-
I
-
S
-
V
A
I
K
T
L
K
V
G
Y
T
E
K
Q
R
R
D
-
F
L
G
E
A
S
I
M
G
Q
F
-
D
-
H
P
N
I
I
R
L
E
G
V
V
T
-
K
S
K
P
V
-----
M
I
V
T
E
Y
M
E
N
G
S
L
D
S
F
L
R
K
-----
H
D
--------------------------------------------
A
------
Q
-------
F
---
T
V
I
Q
------
L
V
G
M
L
R
G
I
A
S
G
M
K
Y
L
S
D
M
G
Y
V
H
R
D
L
A
A
R
N
I
L
I
N
S
-----
N
L
V
C
K
V
S
D
F
G
L
S
R
-
V
L
E
D
----------
K
I
P
I
R
W
T
S
P
E
A
I
A
Y
R
K
F
T
S
A
S
D
V
W
S
Y
G
I
V
L
W
E
V
M
S
-
Y
G
E
R
P
Y
W
E
M
S
-
N
Q
D
V
I
K
A
V
D
E
-------
G
Y
R
L
P
P
P
M
D
C
P
A
A
L
Y
Q
L
M
L
D
C
W
Q
K
D
R
N
N
R
P
K
F
E
Q
I
V
S
I
L
D
K
L
I
--------------------------------------------------------------------------------------------------------------------------------
24
Blastp_CBE
69.06
48%
-134
- C4 -
-
2XBA
1
A:
[3-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
-------
V
Y
E
G
Q
-
V
---------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
----------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
547
Blastp_CBE
69.00
41%
-127
- C4 -
-
2ZV8
1
LYN_MOUSE
A:
[10-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
R
E
S
I
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
--------
M
G
-
Y
Y
N
N
S
-
T
-
K
-
V
A
V
K
T
L
K
P
G
T
M
S
V
Q
A
---
F
L
E
E
A
N
L
M
K
T
L
-
Q
-
H
D
K
L
V
R
L
Y
A
V
V
T
-
K
E
E
P
I
-----
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-----
D
E
-------------------------------------
G
------
G
------
K
-------
V
---
L
L
P
K
------
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
-----
E
S
L
M
C
K
I
A
D
F
G
L
A
R
-
V
I
-------
R
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
-
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
-------
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
---------------------------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
69.04
43%
-133
- C4 -
-
2BDF
1
SRC_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
25
Blastp_CBE
69.00
48%
-125
- C4 -
-
2XB7
1
A:
[3-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
---------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
464
Blastp_CBE
68.96
43%
-145
- C4 -
-
3QLG
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
-----
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
I
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
545
Blastp_CBE
68.94
41%
-128
- C4 -
-
2ZVA
1
LYN_MOUSE
A:
[10-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
R
E
S
I
K
L
V
K
K
L
G
A
G
Q
F
G
E
V
W
--------
M
G
-
Y
Y
N
N
S
-
T
-
K
-
V
A
V
K
T
L
K
P
G
T
M
S
V
Q
A
---
F
L
E
E
A
N
L
M
K
T
L
-
Q
-
H
D
K
L
V
R
L
Y
A
V
V
T
-
K
E
E
P
I
-----
Y
I
I
T
E
F
M
A
K
G
S
L
L
D
F
L
K
S
-----
D
E
-------------------------------------
G
------
G
------
K
-------
V
---
L
L
P
K
------
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
-----
E
S
L
M
C
K
I
A
D
F
G
L
A
R
-
V
I
E
----
T
A
R
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
N
V
W
S
F
G
I
L
L
Y
E
I
V
T
-
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
S
A
L
S
Q
-------
G
Y
R
M
P
R
M
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
---------------------------------------------------------------------------------------------------------------------------------
565
HHSearch
68.91
44%
-119
- C4 -
-
3CBL
3
A:
[113-374]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
--------
D
N
-
T
-
L
-
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
-----
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-----
E
G
--------------------------------------------
A
------
R
-------
L
---
R
V
K
T
------
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
-----
K
N
V
L
K
I
S
D
F
G
M
S
R
-
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-------------------------------------------------------------------------------------------------------------------------------
452
Blastp_CBE
68.90
43%
-142
- C4 -
-
4O2P
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
-------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
389
Blastp_CBE
68.80
43%
-136
- C4 -
-
4MXY
1
SRC_HUMAN
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
L
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
-------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
561
HHSearch
68.82
44%
-118
- C4 -
-
6JMF
1
A:
[111-372]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
--------
D
N
-
T
-
L
-
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
-----
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-----
E
G
--------------------------------------------
A
------
R
-------
L
---
R
V
K
T
------
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
-----
K
N
V
L
K
I
S
D
F
G
M
S
R
-
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-------------------------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
68.80
43%
-136
- C4 -
-
4MXZ
1
SRC_HUMAN
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
L
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
-------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
473
Blastp_CBE
68.73
43%
-134
- C4 -
-
3F6X
1
SRC_CHICK
C:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
----
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
-----------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
195
Blastp_CBE
68.73
42%
-119
- C4 -
-
3CBL
3
A:
[114-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
--------
L
R
A
D
N
-
T
-
L
-
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
-----
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-----
E
--------------------------------------
G
------
A
------
R
-------
L
---
R
V
K
T
------
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
-
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-------------------------------------------------------------------------------------------------------------------------------
533
Blastp_CBE
68.64
43%
-146
- C4 -
-
3G5D
2
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
-----
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
442
Blastp_CBE
68.68
43%
-136
- C4 -
-
5XP5
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
--------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
68.64
43%
-132
- C4 -
-
2BDJ
1
SRC_HUMAN
A:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
438
Blastp_CBE
68.60
41%
-134
- C4 -
-
5XY1
1
LYN_HUMAN
A:
[10-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
R
E
S
I
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
--------
M
G
-
Y
Y
N
N
S
-
T
-
K
-
V
A
V
K
T
L
K
P
G
T
M
S
V
Q
A
---
F
L
E
E
A
N
L
M
K
T
L
-
Q
-
H
D
K
L
V
R
L
Y
A
V
V
T
-
R
E
E
P
I
-----
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
-----
D
E
-------------------------------------
G
------
G
------
K
-------
V
---
L
L
P
K
------
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
-----
E
S
L
M
C
K
I
A
D
F
G
L
A
R
-
V
-------------
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
-
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
T
A
L
S
Q
-------
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
---------------------------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
68.57
43%
-133
- C4 -
-
2BDF
1
SRC_HUMAN
B:
[8-263]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
----------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
474
Blastp_CBE
68.47
43%
-135
- C4 -
-
3F6X
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
478
Blastp_CBE
68.48
43%
-141
- C4 -
-
3EN5
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
468
Blastp_CBE
68.47
43%
-136
- C4 -
-
3OEZ
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
I
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
447
Blastp_CBE
68.45
43%
-142
- C4 -
-
4YBK
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
-------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
480
Blastp_CBE
68.42
43%
-137
- C4 -
-
3EN4
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
461
Blastp_CBE
68.39
43%
-134
- C4 -
-
3UQG
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
--------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
466
Blastp_CBE
68.37
43%
-141
- C4 -
-
3QLF
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
--
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
I
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
------------------
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
359
Blastp_CBE
68.30
43%
-133
- C4 -
-
3GEQ
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
--------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
360
Blastp_CBE
68.29
43%
-133
- C4 -
-
3GEQ
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
A
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
---------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
451
Blastp_CBE
68.25
43%
-138
- C4 -
-
4U5J
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
--------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
53
Blastp_CBE
68.24
49%
-128
- C4 -
-
4FNY
1
A:
[22-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
---
G
E
V
Y
E
G
Q
-
V
S
G
--------
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
------------------------------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
-----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
564
HHSearch
68.06
44%
-115
- C4 -
-
3BKB
7
A:
[113-374]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
R
A
--------
D
N
-
T
-
L
-
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
-----
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-----
E
G
--------------------------------------------
A
------
R
-------
L
---
R
V
K
T
------
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
-----
K
N
V
L
K
I
S
D
F
G
M
S
R
-
E
E
A
D
G
V
Y
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-------------------------------------------------------------------------------------------------------------------------------
446
Blastp_CBE
68.06
43%
-137
- C4 -
-
5J5S
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
390
Blastp_CBE
68.03
43%
-139
- C4 -
-
4MXY
1
SRC_HUMAN
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
L
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
194
Blastp_CBE
68.05
42%
-123
- C4 -
-
4E93
1
A:
[114-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
--------
L
R
A
D
N
-
T
-
L
-
V
A
V
K
S
C
R
E
T
L
P
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
-----
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-----
E
--------------------------------------
G
------
A
------
R
-------
L
---
R
V
K
T
------
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
-
E
--------------
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-------------------------------------------------------------------------------------------------------------------------------
551
Blastp_CBE
68.00
43%
-139
- C4 -
-
5TEH
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
388
Blastp_CBE
68.03
43%
-139
- C4 -
-
4MXZ
1
SRC_HUMAN
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
L
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
465
Blastp_CBE
68.00
43%
-139
- C4 -
-
3QLG
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
I
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
516
Blastp_CBE
67.95
43%
-132
- C4 -
-
4MCV
1
SRC_CHICK
A:
[7-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
---------
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
498
Blastp_CBE
67.95
43%
-151
- C4 -
-
5D11
2
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
------------
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.92
48%
-129
- C4 -
-
4CNH
1
ALK_HUMAN
A:
[11-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
Y
C
F
A
G
K
T
----
S
S
I
S
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
------
E
V
Y
E
G
Q
-
V
---------
S
P
-
L
-
Q
-
V
A
V
K
T
L
P
E
V
C
S
E
Q
D
E
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
R
----------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
460
Blastp_CBE
67.87
43%
-141
- C4 -
-
3UQG
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
----
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
--------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
441
Blastp_CBE
67.80
43%
-132
- C4 -
-
5XP5
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
--------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
529
Blastp_CBE
67.78
43%
-139
- C4 -
-
3TZ8
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
457
Blastp_CBE
67.75
43%
-136
- C4 -
-
4DGG
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
450
Blastp_CBE
67.67
43%
-131
- C4 -
-
4U5J
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
--------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
475
Blastp_CBE
67.62
43%
-141
- C4 -
-
3F6X
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
-----
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
-----------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
550
Blastp_CBE
67.63
43%
-138
- C4 -
-
5TEH
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
443
Blastp_CBE
67.62
43%
-137
- C4 -
-
5K9I
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
471
Blastp_CBE
67.55
43%
-134
- C4 -
-
3G6G
3
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
---------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
481
Blastp_CBE
67.58
43%
-136
- C4 -
-
3EN4
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
--
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
463
Blastp_CBE
67.55
43%
-141
- C4 -
-
3UQF
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
488
Blastp_CBE
67.49
43%
-134
- C4 -
-
2OIQ
3
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
--------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
504
Blastp_CBE
67.44
43%
-139
- C4 -
-
3F3W
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
490
Blastp_CBE
67.37
43%
-136
- C4 -
-
3SVV
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
431
Blastp_CBE
67.33
43%
-138
- C4 -
-
4MXX
1
SRC_HUMAN
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
T
D
F
G
L
A
R
-
L
I
E
------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
505
Blastp_CBE
67.29
43%
-139
- C4 -
-
3F3W
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
462
Blastp_CBE
67.29
43%
-147
- C4 -
-
3UQF
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
-------
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
430
Blastp_CBE
67.30
43%
-136
- C4 -
-
4MXX
1
SRC_HUMAN
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
T
D
F
G
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
415
Blastp_CBE
67.29
43%
-136
- C4 -
-
3U51
1
SRC_CHICK
A:
[4-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
---------
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
469
Blastp_CBE
67.22
43%
-134
- C4 -
-
3OEZ
2
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
I
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
515
Blastp_CBE
67.19
43%
-133
- C4 -
-
4MCV
1
SRC_CHICK
B:
[7-262]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
---------
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
-
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
520
Blastp_CBE
67.14
43%
-133
- C4 -
-
5T0P
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
C
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
--------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
445
Blastp_CBE
67.16
43%
-139
- C4 -
-
5J5S
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
470
Blastp_CBE
67.14
43%
-136
- C4 -
-
3G6G
2
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
----------------
G
-
A
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
489
Blastp_CBE
67.12
43%
-141
- C4 -
-
3SVV
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
-
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
C
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
482
Blastp_CBE
67.07
43%
-132
- C4 -
-
3EL8
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
444
Blastp_CBE
67.00
43%
-138
- C4 -
-
5K9I
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
499
Blastp_CBE
66.97
43%
-148
- C4 -
-
5D11
2
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
---------
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
521
Blastp_CBE
66.95
43%
-136
- C4 -
-
5T0P
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
C
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
--------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
453
Blastp_CBE
66.88
43%
-131
- C4 -
-
4O2P
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
--
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
E
D
-----------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
537
Blastp_CBE
66.86
43%
-134
- C4 -
-
3F3U
2
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
517
Blastp_CBE
66.78
42%
-140
- C4 -
-
1YOM
1
SRC_HUMAN
B:
[12-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
456
Blastp_CBE
66.78
43%
-140
- C4 -
-
4DGG
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
------
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
--------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
538
Blastp_CBE
66.74
43%
-139
- C4 -
-
3F3T
2
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
552
Blastp_CBE
66.69
43%
-134
- C4 -
-
5SYS
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
C
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
414
Blastp_CBE
66.66
43%
-136
- C4 -
-
3U51
1
B:
[4-259]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
---------
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
536
Blastp_CBE
66.62
43%
-135
- C4 -
-
3F3U
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
--
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
486
Blastp_CBE
66.59
43%
-132
- C4 -
-
3D7T
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
I
------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
528
Blastp_CBE
66.47
43%
-136
- C4 -
-
3TZ8
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-----------------
K
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
88
Blastp_CBE
66.45
50%
-51
- C4 -
-
3ETA
1
INSR_HUMAN
A:
[15-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
-
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
467
Blastp_CBE
66.40
43%
-147
- C4 -
-
3QLF
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
------------
L
Q
E
A
Q
V
M
K
K
I
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
66.36
43%
-134
- C4 -
-
1YOL
1
SRC_HUMAN
A:
[12-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
458
Blastp_CBE
66.30
43%
-134
- C4 -
-
4AGW
3
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
535
Blastp_CBE
66.25
43%
-134
- C4 -
-
3F3V
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
66.14
48%
-126
- C4 -
-
5IMX
1
A:
[25-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
Q
-
V
---------
S
P
-
L
-
Q
-
V
A
V
K
T
L
---------
L
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
----------
P
---------
S
Q
-----
P
------
S
------
S
-------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
66.09
43%
-132
- C4 -
-
1YOL
1
SRC_HUMAN
B:
[12-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
137
Blastp_CBE
66.02
44%
-127
- C4 -
-
4UEU
1
?
A:
[8-268]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
--------
N
-
I
-
E
-
V
A
V
K
T
L
K
E
G
T
M
S
V
E
--
E
-
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
E
P
P
I
-----
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
-----
C
E
-------------------------------------
G
------
H
------
T
-------
V
---
N
A
Q
A
------
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
-----
V
V
K
V
A
D
F
G
L
A
R
-
L
I
-----------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
-
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
-------
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
---
A
E
T
L
H
A
L
E
T
M
F
-----------------------------------------------------------------------------------------------------------------------------
539
Blastp_CBE
66.01
43%
-148
- C4 -
-
2QLQ
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
-----------------
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-----------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
138
Blastp_CBE
65.96
44%
-133
- C4 -
-
4CSV
1
?
A:
[8-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
S
E
I
T
L
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
K
W
R
N
Y
--------
N
-
I
-
E
-
V
A
V
K
T
L
K
E
G
T
M
S
V
E
--
E
-
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
-
K
E
P
P
I
-----
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
R
D
-----
C
------------------------------------------------------------
V
---
N
A
Q
A
------
L
L
D
M
A
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
E
N
N
-----
V
V
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
-
Y
G
Q
V
P
Y
P
G
M
S
-
G
S
E
V
I
E
Q
V
E
R
-------
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
---
A
E
T
L
H
A
L
E
T
M
F
L
----------------------------------------------------------------------------------------------------------------------------
95
Blastp_CBE
65.90
49%
-55
- C4 -
-
5HHW
2
?
A:
[17-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
397
Blastp_CBE
65.72
43%
-129
- C4 -
-
3G6H
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
I
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
459
Blastp_CBE
65.56
43%
-133
- C4 -
-
4AGW
3
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
454
Blastp_CBE
65.55
43%
-146
- C4 -
-
4FIC
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
-----------------
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
500
Blastp_CBE
65.48
43%
-156
- C4 -
-
5D10
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
----------------
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
455
Blastp_CBE
65.42
43%
-149
- C4 -
-
4FIC
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
-----------
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
-------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
476
Blastp_CBE
65.37
43%
-151
- C4 -
-
3EN7
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
---------
N
---
T
-
R
-
V
A
I
K
T
L
K
P
----------
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
518
Blastp_CBE
65.35
42%
-126
- C4 -
-
1YOM
1
SRC_HUMAN
A:
[12-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
N
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
S
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
87
Blastp_CBE
65.30
50%
-53
- C4 -
-
3ETA
1
B:
[15-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
493
Blastp_CBE
65.22
43%
-151
- C4 -
-
6HVF
3
?
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
-------------
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
136
Blastp_CBE
65.15
43%
-55
- C4 -
-
2IVS
5
RET_HUMAN
A:
[20-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-----
S
R
-------
K
-
V
---------------------------
G
------
P
GYLR--
A
-------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
Y
E
E
D
S
Y
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
506
Blastp_CBE
65.14
43%
-152
- C4 -
-
2QQ7
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
----------------
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
383
Blastp_CBE
65.12
43%
-135
- C4 -
-
6ATE
1
SRC_HUMAN
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
--------
M
G
-
T
W
N
G
T
-
T
-
R
-
V
A
I
K
T
L
------
P
E
A
---
F
--
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
K
G
-----
E
T
-------------------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
---------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
E
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
519
Blastp_CBE
64.91
41%
-118
- C4 -
-
3A4O
1
LYN_HUMAN
X:
[11-268]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
-----
R
E
S
I
K
L
V
K
R
L
G
A
G
Q
F
G
E
V
W
--------
M
G
-
Y
Y
N
N
S
-
T
-
K
-
V
A
V
K
T
L
K
P
G
T
M
S
V
Q
A
---
F
L
E
E
A
N
L
M
K
T
L
-
Q
-
H
D
K
L
V
R
L
Y
A
V
V
T
-
R
E
E
P
I
-----
Y
I
I
T
E
Y
M
A
K
G
S
L
L
D
F
L
K
S
-----
D
E
-------------------------------------
G
------
G
------
K
-------
V
---
L
L
P
K
------
L
I
D
F
S
A
Q
I
A
E
G
M
A
Y
I
E
R
K
N
Y
I
H
R
D
L
R
A
A
N
V
L
V
S
-----
E
S
L
M
C
K
I
A
D
F
G
L
A
R
-
V
---------
E
G
-
A
K
F
P
I
K
W
T
A
P
E
A
I
N
F
G
C
F
T
I
K
S
D
V
W
S
F
G
I
L
L
Y
E
I
V
T
-
Y
G
K
I
P
Y
P
G
R
T
-
N
A
D
V
M
T
A
L
S
Q
-------
G
Y
R
M
P
R
V
E
N
C
P
D
E
L
Y
D
I
M
K
M
C
W
K
E
K
A
E
E
R
P
T
F
D
Y
L
Q
S
V
L
D
D
F
---------------------------------------------------------------------------------------------------------------------------------
502
Blastp_CBE
64.76
43%
-151
- C4 -
-
3LOK
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
------------------
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
494
Blastp_CBE
64.72
43%
-153
- C4 -
-
6HVE
1
?
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
--------------
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
83
Blastp_CBE
64.63
50%
-49
- C4 -
-
4IBM
1
?
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
411
Blastp_CBE
64.54
40%
-74
- C4 -
-
6D20
2
A:
[31-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
--------------------------------------
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
93
Blastp_CBE
64.41
49%
-69
- C4 -
-
3EKN
1
A:
[17-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
540
Blastp_CBE
64.39
43%
-157
- C4 -
-
2QLQ
2
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
----------------
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
-
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
492
Blastp_CBE
64.32
43%
-144
- C4 -
-
6HVF
2
?
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
-------------
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
503
Blastp_CBE
64.24
43%
-151
- C4 -
-
3LOK
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
---
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
---------------
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
---------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
568
HHSearch
64.14
39%
-115
- C4 -
-
6BRJ
1
DDR1_HUMAN
A:
[568-871]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
-------------
L
-
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
D
D
P
L
-----
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-----
H
Q
-------
L
-
E
----------
D
-----------------------
P
------
T
-------
I
---
S
Y
P
M
------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
-----
N
F
T
I
K
I
A
D
F
G
M
S
R
-
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
-
D
E
Q
V
I
E
N
A
G
E
FFRDQGR
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
---------------------------------------------------------------------------------------------------------------------------------
483
Blastp_CBE
64.09
43%
-133
- C4 -
-
3EL7
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
-
T
M
S
P
E
A
---
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
--
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
507
Blastp_CBE
64.05
43%
-148
- C4 -
-
2QQ7
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
--------------
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
A
R
-
L
---------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
514
Blastp_CBE
64.02
43%
-148
- C4 -
-
4LGH
1
SRC_CHICK
A:
[6-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
---------
N
G
--
T
-
R
-
V
A
I
K
T
L
---------------
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
542
Blastp_CBE
63.98
43%
-156
- C4 -
-
2HWP
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
--
V
K
L
G
Q
G
C
-
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
-------------
F
L
Q
-
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
-
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
--------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
36
Blastp_CBE
63.96
48%
-141
- C4 -
-
4JOA
1
A:
[41-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
E
V
P
-----
R
K
N
I
T
L
I
R
G
L
G
------
V
Y
E
G
Q
-
V
S
-----------
L
-
Q
-
V
A
V
K
T
L
P
---------
D
-
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
-
Q
S
L
P
R
-----
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
-----
T
R
-------
P
-
R
-------------------------------------------------
L
---
A
M
L
D
------
L
L
H
V
A
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
C
P
G
--
P
G
R
V
A
K
I
G
D
F
G
M
A
R
-
D
I
Y
----------
A
M
L
P
V
K
W
M
P
P
E
A
---
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
-
L
G
Y
M
P
Y
P
S
K
S
-
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
I
L
E
R
I
E
-----------------------------------------------------------------------------------------------------------------------------------
317
Blastp_CBE
63.91
42%
-74
- C4 -
-
4AT3
1
A:
[12-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
--
L
C
-----
K
-
I
-
L
-
V
A
V
K
T
L
--
A
S
-
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
-
E
G
D
P
L
-----
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
HGPDA
V
L
-------
M
-
A
---------------------
N
-----
P
------
P
------
T
E------
L
---
T
Q
S
Q
------
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
---
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
N
E
V
I
E
C
I
T
Q
-------
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
541
Blastp_CBE
63.60
43%
-151
- C4 -
-
2HWP
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
---
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
-----------------
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
----------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
409
Blastp_CBE
63.56
40%
-73
- C4 -
-
6DKG
2
A:
[31-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD----------------------------------------
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
------
Y
S
T
D
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
412
Blastp_CBE
63.39
40%
-76
- C4 -
-
6D1Z
3
A:
[31-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD----------------------------------------
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
82
Blastp_CBE
63.25
50%
-51
- C4 -
-
4IBM
1
?
B:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
----
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
513
Blastp_CBE
63.18
43%
-133
- C4 -
-
4LGH
1
SRC_CHICK
B:
[6-261]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
-
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
-------------
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
G
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
L
-------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
544
Blastp_CBE
63.17
43%
-151
- C4 -
-
2HWO
2
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
-
G
C
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
----------
F
L
Q
E
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
--
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
G
--------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
421
Blastp_CBE
63.18
40%
-82
- C4 -
-
5JFV
1
A:
[19-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGP------------------------------------VAP--
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
420
Blastp_CBE
63.17
40%
-81
- C4 -
-
5JFW
1
A:
[19-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGP------------------------------------VAP--
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
80
Blastp_CBE
63.09
50%
-61
- C4 -
-
3QQU
1
IGF1R_HUMAN
B:
[11-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
------------------------------------------------------------P--
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
97
Blastp_CBE
63.00
49%
-65
- C4 -
-
1I44
1
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
-----------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
94
Blastp_CBE
62.88
49%
-71
- C4 -
-
3EKK
1
A:
[17-288]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
-------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
410
Blastp_CBE
62.87
40%
-64
- C4 -
-
6DKB
1
A:
[31-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HG-------------------------------------P----
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-------
S
T
D
Y
Y
R
-----
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
72
Blastp_CBE
62.86
50%
-64
- C4 -
-
1JQH
1
IGF1R_HUMAN
A:
[18-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
-----------------------------------------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
--------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
408
Blastp_CBE
62.84
40%
-71
- C4 -
-
6DKI
2
A:
[31-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD----------------------------------------
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
--
R
-
D
I
Y
S
T
D
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
413
Blastp_CBE
62.82
40%
-73
- C4 -
-
6D1Y
1
A:
[31-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
-----
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-----------------------------
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
68
Blastp_CBE
62.77
50%
-59
- C4 -
-
5FXQ
1
A:
[18-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
M
----------------
N
------
P
------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
96
Blastp_CBE
62.75
49%
-70
- C4 -
-
5E1S
1
A:
[18-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
62.65
40%
-55
- C4 -
-
6NSP
1
A:
[8-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
---------------------
A
---------
G
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
543
Blastp_CBE
62.64
43%
-143
- C4 -
-
2HWO
2
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
--
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
----------------
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
---------------------
F
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
477
Blastp_CBE
62.62
43%
-156
- C4 -
-
3EN6
1
SRC_CHICK
B:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
--
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
----------------
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
---
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
F
----------------------
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
501
Blastp_CBE
62.61
43%
-135
- C4 -
-
5D10
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
----
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
K
P
G
T
M
S
P
E
A
-------
A
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
M
E
Y
M
S
K
G
C
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
D
----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
419
Blastp_CBE
62.55
40%
-82
- C4 -
-
5JFX
1
A:
[19-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGP------------------------------------VAP--
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
479
Blastp_CBE
62.54
43%
-150
- C4 -
-
3EN5
1
SRC_CHICK
A:
[15-270]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
-----
R
E
S
L
R
L
E
V
K
L
G
Q
G
-
F
G
E
V
W
M
G
T
W
---------
N
G
T
-
T
-
R
-
V
A
I
K
T
L
-----------------
Q
V
M
K
K
L
-
R
-
H
E
K
L
V
-
Q
L
Y
A
V
V
-
S
E
E
P
I
-----
Y
I
V
T
E
Y
M
S
K
G
S
L
L
D
F
L
-
K
-----
G
E
-------
M
-----------------------------
G
------
K
------
Y
-------
L
---
R
L
P
Q
------
L
V
D
M
A
A
Q
I
A
S
G
M
A
Y
V
E
R
M
N
Y
V
H
R
D
L
R
A
A
N
I
L
V
G
-----
E
N
L
V
C
K
V
A
-----------------------
P
I
K
W
T
A
P
E
A
A
L
Y
G
R
F
T
I
K
S
D
V
W
S
F
G
I
L
L
T
E
L
T
T
-
K
G
R
V
P
Y
P
G
M
V
-
N
R
E
V
L
D
Q
V
E
R
-------
G
Y
R
M
P
C
P
P
E
C
P
E
S
L
H
D
L
M
C
Q
C
W
R
K
D
P
E
E
R
P
T
F
E
Y
L
Q
A
F
L
E
-----------------------------------------------------------------------------------------------------------------------------------
316
Blastp_CBE
62.46
42%
-69
- C4 -
-
4AT4
1
A:
[12-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
--
L
C
-----
K
-
I
-
L
-
V
A
V
K
T
L
K
D
A
S
-
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
-
E
G
D
P
L
-----
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
HGPDA
V
L
-------
M
-
A
---------------------------
P
------
P
------
T
E------
L
---
T
Q
S
Q
------
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
-
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
N
E
V
I
E
C
I
T
Q
-------
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
75
Blastp_CBE
62.45
50%
-50
- C4 -
-
3NW6
1
A:
[17-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
M
---------
E
N
-----
N
------
P
------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
315
Blastp_CBE
62.36
42%
-69
- C4 -
-
4AT5
2
A:
[12-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
H
N
I
V
L
K
R
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
Y
N
--
L
------
K
-
I
-
L
-
V
A
V
K
T
L
K
D
A
S
-
D
N
A
R
K
D
-
F
H
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
V
-
E
G
D
P
L
-----
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
HGPDA
V
L
-------
M
-
A
----------
E
---------
G
N
-----
P
------
P
------
T
E------
L
---
T
Q
S
Q
------
M
L
H
I
A
Q
Q
I
A
A
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
E
N
L
L
V
K
I
G
D
F
G
M
S
R
-
D
V
Y
S
T
D
Y
Y
R
V
G
G
H
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
L
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
N
E
V
I
E
C
I
T
Q
-------
G
R
V
L
Q
R
P
R
T
C
P
Q
E
V
Y
E
L
M
L
G
C
W
Q
R
E
P
H
M
R
K
N
I
K
G
I
H
T
L
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
406
Blastp_CBE
62.33
40%
-61
- C4 -
-
6PL3
1
A:
[23-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
-
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-----------------------
A
---------
G
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
91
Blastp_CBE
62.33
50%
-56
- C4 -
-
3LVP
1
IGF1R_HUMAN
B:
[46-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
-----------------------------------------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
69
Blastp_CBE
62.21
50%
-63
- C4 -
-
3I81
1
A:
[17-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
--------------------
E
N
-----
N
------
P
------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
90
Blastp_CBE
62.13
50%
-49
- C4 -
-
3LVP
1
IGF1R_HUMAN
C:
[46-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
-----------------------------------------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
135
Blastp_CBE
62.08
43%
-67
- C4 -
-
2IVS
3
B:
[20-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-----
S
R
-------
K
-------------------------------------R-----
A
-------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
-----------
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
70
Blastp_CBE
62.08
50%
-62
- C4 -
-
1JQH
1
C:
[18-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
-----------------------------------------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
--------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
422
Blastp_CBE
62.00
40%
-82
- C4 -
-
5JFS
1
A:
[19-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGP------------------------------------VAP--
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
433
Blastp_CBE
61.96
40%
-80
- C4 -
-
4AOJ
1
NTRK1_HUMAN
B:
[40-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
---
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD----------------------------------------
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
--------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
84
Blastp_CBE
61.79
50%
-58
- C4 -
-
5FXR
1
A:
[18-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
-
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
M
---------
E
N
-----
N
------
P
------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
428
Blastp_CBE
61.77
40%
-49
- C4 -
-
5KMJ
1
A:
[34-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
---
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------------------------------
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
92
Blastp_CBE
61.74
50%
-66
- C4 -
-
3LVP
2
IGF1R_HUMAN
A:
[46-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
M
---------
E
-------------
P
------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
-------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
417
Blastp_CBE
61.68
40%
-75
- C4 -
-
6DKW
1
B:
[19-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------------------------------------
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
85
Blastp_CBE
61.67
50%
-54
- C4 -
-
4D2R
1
A:
[12-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
M
---------
E
N
-----
N
------
P
------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
98
Blastp_CBE
61.64
49%
-55
- C4 -
-
5FXS
1
A:
[18-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
M
---------
E
N
-----
N
------
P
------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
A
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
E
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
427
Blastp_CBE
61.62
40%
-56
- C4 -
-
5KMK
1
A:
[34-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
----------------------
G
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
425
Blastp_CBE
61.61
40%
-57
- C4 -
-
5KMM
1
A:
[34-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
----------------------
G
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
74
Blastp_CBE
61.57
50%
-56
- C4 -
-
3NW7
1
A:
[17-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
M
---------
E
N
-----
N
------
P
------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
407
Blastp_CBE
61.51
40%
-55
- C4 -
-
6NSS
1
A:
[23-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
---------
G
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
177
Blastp_CBE
61.51
40%
-58
- C4 -
-
4PMP
1
A:
[7-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
------
K
-
M
-
L
-
V
A
V
K
A
L
K
-----
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
GGEDV----
A
P
-----
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
--
I
Y
S
T
D
Y
Y
R
V
G
--
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
423
Blastp_CBE
61.44
40%
-56
- C4 -
-
5KMO
1
A:
[34-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
----------------------
G
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
--
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
429
Blastp_CBE
61.30
40%
-50
- C4 -
-
5KMI
1
A:
[34-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
----
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-----------------------
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
434
Blastp_CBE
61.29
40%
-73
- C4 -
-
4AOJ
1
NTRK1_HUMAN
A:
[40-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
---
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-----------------------------------P----
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-----------------
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
432
Blastp_CBE
61.05
40%
-80
- C4 -
-
4AOJ
1
C:
[40-315]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
-
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD----------------------------------------
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
-----------------
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
418
Blastp_CBE
61.00
40%
-78
- C4 -
-
6DKW
1
NTRK1_HUMAN
A:
[19-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
E
Q
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
---------
G
G
ED---
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-------------------
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
569
HHSearch
60.93
39%
-67
- C4 -
-
6BSD
1
DDR1_HUMAN
A:
[568-871]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
S
R
L
R
F
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
E
V
D
S
---------
P
-
L
-
L
-
V
A
V
K
I
L
R
P
D
A
T
K
N
A
R
N
D
-
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
-
Q
D
D
P
L
-----
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
-----
H
Q
-------
L
-
E
----------
D
KA--------------
G
------
P
------
T
-------
I
---
S
Y
P
M
------
L
L
H
V
A
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
E
-----
N
F
T
I
K
I
A
D
F
G
--
R
-
N
L
Y
A
G
D
Y
Y
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
-
D
E
Q
V
I
E
N
A
G
E
FFRDQGR
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
L
H
R
F
L
A
E
D
---------------------------------------------------------------------------------------------------------------------------------
76
Blastp_CBE
60.93
50%
-46
- C4 -
-
3NW5
1
A:
[17-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
M
---------
E
N
-----
N
------
P
------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
178
Blastp_CBE
60.82
40%
-56
- C4 -
-
4PMM
2
A:
[7-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
-----
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
----
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
GGEDV----
A
P
-----
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
424
Blastp_CBE
60.75
40%
-54
- C4 -
-
5KMN
1
A:
[35-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
--
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
-
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
--------------------------------
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
81
Blastp_CBE
60.64
50%
-22
- C4 -
-
3QQU
1
IGF1R_HUMAN
A:
[11-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
------------------------------------------------------------PP-
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
189
Blastp_CBE
60.52
40%
-63
- C4 -
-
4YNE
2
A:
[14-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
P
----
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
------
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
GGEDV----
A
P
-----
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
------
S
T
D
Y
Y
----
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
60.47
41%
-36
- C4 -
-
5EG3
1
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG------
N
----------
R
---------
V
P
-----
E
------
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
F
F
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
426
Blastp_CBE
60.40
40%
-54
- C4 -
-
5KML
1
A:
[35-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
--
P
--
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
-
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
--------------------------------
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
142
Blastp_CBE
60.21
42%
-105
- C4 -
-
2X2M
4
B:
[20-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
----
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-----
S
----------------------------------------------------
A
-------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
Y
E
E
D
S
V
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
59.99
40%
-34
- C4 -
-
5A46
4
FGFR1_HUMAN
A:
[37-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-------------------------------------EE----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-------------------------------------------------------------------------------------------------------------------------
285
Blastp_CBE
59.95
41%
-34
- C4 -
-
3RHX
5
FGFR1_HUMAN
A:
[14-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
354
Blastp_CBE
59.76
42%
-65
- C4 -
-
3BPR
1
MERTK_HUMAN
A:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
K
------
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
M
S
S
-P----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
78
Blastp_CBE
59.74
50%
-47
- C4 -
-
3QQU
1
D:
[11-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
M
--------------------------------------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
570
HHSearch
59.73
42%
-46
- C4 -
-
5A46
2
B:
[37-323]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
---D
K
P
N
R
V
-
T
-
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
-------
P
-
P
-----------H--------
N
P
-----
E
------
E
------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
-----
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
-------------------------------------------------------------------------------------------------------------------------------
168
Blastp_CBE
59.67
43%
-23
- C4 -
-
4J97
1
FGFR2_HUMAN
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
---
G
Q
V
V
M
A
E
A
V
G
I
----
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG-----------------------------------PE----
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
79
Blastp_CBE
59.66
50%
-47
- C4 -
-
3QQU
1
IGF1R_HUMAN
C:
[11-277]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
M
------------------------------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
224
Blastp_CBE
59.62
41%
-35
- C4 -
-
1FGI
1
FGFR1_HUMAN
A:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
192
Blastp_CBE
59.60
43%
-31
- C4 -
-
4J99
1
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG----
M
-
E
----------
Y
---------
S
Y
-----
D
-------------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
351
Blastp_CBE
59.52
42%
-66
- C4 -
-
3BPR
1
D:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
K
--------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
M
S
S
-P----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
340
Blastp_CBE
59.47
42%
-67
- C4 -
-
5K0K
1
MERTK_HUMAN
A:
[26-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
----PKP--
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
187
Blastp_CBE
59.47
40%
-56
- C4 -
-
6J5L
1
A:
[14-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-------
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
GGEDV----
A
P
-----
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-----
I
Y
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
173
Blastp_CBE
59.42
43%
-22
- C4 -
-
4J98
1
FGFR2_HUMAN
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG----
M
-
E
----------
Y
---------
S
Y
-----
D
INRVPE
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
Q
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
304
Blastp_CBE
59.41
43%
-28
- C4 -
-
5UI0
1
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG----
M
-
E
----------
Y
---------
S
Y
-----
D
INRVPE
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
176
Blastp_CBE
59.33
40%
-51
- C4 -
-
4PMS
1
A:
[7-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-
L
-----
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
----
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
GGEDV----
A
P
-----
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
--
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
292
Blastp_CBE
59.29
41%
-26
- C4 -
-
5VND
10
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-----
N
------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
170
Blastp_CBE
59.29
43%
-26
- C4 -
-
3RI1
1
?
A:
[21-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PP------------------------------------------
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
148
Blastp_CBE
59.27
42%
-94
- C4 -
-
2IVV
3
A:
[20-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-----
S
R
-----------------------------------------------------------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
S
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
Y
E
E
D
S
V
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
303
Blastp_CBE
59.25
41%
-33
- C4 -
-
3JS2
1
FGFR1_HUMAN
A:
[25-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-------------------------------------HNPEE-
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
157
Blastp_CBE
59.22
43%
-30
- C4 -
-
2PWL
1
FGFR2_HUMAN
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
P-------------------------------------------
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
291
Blastp_CBE
59.19
41%
-34
- C4 -
-
5VND
8
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG------------------------------------------EE----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
201
Blastp_CBE
59.11
43%
-28
- C4 -
-
5UHN
1
FGFR2_HUMAN
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
--------------------------------------E-----
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
89
Blastp_CBE
59.08
50%
-60
- C4 -
-
3LVP
2
D:
[46-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
----------
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
-----------------------------------------
V
-------
L
APP
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
202
Blastp_CBE
59.02
43%
-22
- C4 -
-
4J96
1
FGFR2_HUMAN
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG----
M
-
E
----------
Y
---------
S
Y
-----
D
INRVPE
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
156
Blastp_CBE
58.99
43%
-27
- C4 -
-
2PWL
1
FGFR2_HUMAN
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG-----------------------------------------
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
402
Blastp_CBE
58.98
41%
-62
- C4 -
-
5NWZ
1
FGFR4_HUMAN
A:
[16-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
GPDL------------------------------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
294
Blastp_CBE
58.97
41%
-33
- C4 -
-
3C4F
1
FGFR1_HUMAN
A:
[10-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
302
Blastp_CBE
58.87
41%
-36
- C4 -
-
3JS2
1
B:
[25-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
251
Blastp_CBE
58.86
41%
-28
- C4 -
-
4UWC
9
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
------------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
205
Blastp_CBE
58.78
43%
-28
- C4 -
-
2PY3
1
FGFR2_HUMAN
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
--------------------------------------PE----
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
287
Blastp_CBE
58.72
41%
-30
- C4 -
-
6P69
3
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
548
Blastp_CBE
58.69
41%
-74
- C4 -
-
3V5Q
1
B:
[14-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
R
E
L
G
---
F
-
K
V
F
L
A
E
C
Y
N
--
L
S
-
P
T
K
D
K
-
M
-
L
-
V
A
V
K
A
L
K
D
P
T
L
A
A
R
K
-
D
-
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
---
G
D
P
L
-----
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
--------------------------------------
H
-----
G
------
P
----------------------ELGLSQ
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
A
N
L
L
V
K
I
G
D
F
G
M
---
D
V
Y
S
T
D
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
G
K
Q
P
W
F
Q
L
S
-
N
T
E
V
I
E
C
I
T
Q
-------
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
----------------------------------------------------------------------------------------------------------------------------------------------
289
Blastp_CBE
58.66
41%
-35
- C4 -
-
6P68
1
FGFR1_HUMAN
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
350
Blastp_CBE
58.63
42%
-69
- C4 -
-
3BRB
2
MERTK_HUMAN
A:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
---
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
----KP---
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
-----------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
293
Blastp_CBE
58.60
41%
-30
- C4 -
-
3C4F
1
B:
[10-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
167
Blastp_CBE
58.60
43%
-20
- C4 -
-
4J97
1
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
---
G
Q
V
V
M
A
E
A
V
G
I
-
D
------
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG-----------------------------------INRVPE
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
166
Blastp_CBE
58.54
43%
-29
- C4 -
-
4J97
1
?
C:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
---
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
------
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PP------------------------------------INRVPE
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
348
Blastp_CBE
58.50
42%
-65
- C4 -
-
3TCP
1
MERTK_HUMAN
A:
[26-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
-----
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
----PKP--
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
204
Blastp_CBE
58.52
43%
-30
- C4 -
-
2PY3
1
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
----
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG-----------------------------------E-----
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
325
Blastp_CBE
58.50
43%
-26
- C4 -
-
5UGX
1
FGFR2_HUMAN
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG----
M
-
E
----------
Y
---------
S
Y
-----
D
INRVPE
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
V
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
232
Blastp_CBE
58.48
41%
-33
- C4 -
-
4ZSA
1
FGFR1_HUMAN
A:
[16-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
352
Blastp_CBE
58.43
42%
-62
- C4 -
-
3BPR
1
MERTK_HUMAN
C:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
K
--------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
M
S
--KP---
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
405
Blastp_CBE
58.39
40%
-48
- C4 -
-
5H3Q
3
A:
[35-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
---------
K
-
M
-
L
-
V
A
V
K
A
L
K
E
-----
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
---------
G
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
512
Blastp_CBE
58.36
41%
-53
- C4 -
-
5KVT
2
A:
[7-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-------
D
K
-
M
-
L
-
V
A
V
K
A
L
K
E
A
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
---------
G
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
G
G
R
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
---
H
S
I
K
D
--------------------------------------------------------------------------------------------------------------------------------------
572
HHSearch
58.30
42%
-24
- C4 -
-
3TT0
1
FGFR1_HUMAN
A:
[66-353]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
D
K
P
N
R
V
-
T
-
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
-------
P
-
P
----------
G
LEYSYNPSH
N
P
-----
E
------
E
------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
E
-----
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
------------------------------------------------------------------------------------------------------------------------------
296
Blastp_CBE
58.34
41%
-21
- C4 -
-
4RWK
1
FGFR1_HUMAN
A:
[25-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-----
N
------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
186
Blastp_CBE
58.31
43%
-21
- C4 -
-
2PVY
1
?
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG----
M
-----------------------------
D
INRVPE
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
169
Blastp_CBE
58.30
43%
-25
- C4 -
-
3RI1
1
FGFR2_HUMAN
B:
[21-302]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
----
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PP------------------------------------------
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
234
Blastp_CBE
58.29
43%
-40
- C4 -
-
5UGL
1
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
---------------------------------------RVPE--
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
V
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
313
Blastp_CBE
58.28
40%
-38
- C4 -
-
3GQL
1
FGFR1_HUMAN
B:
[25-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-------------------------------------------------------------------------------------------------------------------------
242
Blastp_CBE
58.26
41%
-36
- C4 -
-
5EW8
1
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
228
Blastp_CBE
58.26
41%
-29
- C4 -
-
6ITJ
1
?
A:
[16-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
349
Blastp_CBE
58.24
42%
-47
- C4 -
-
3BRB
2
B:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
M
S
S
Q
GIPKP
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
233
Blastp_CBE
58.22
43%
-42
- C4 -
-
5UGL
1
?
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
P----------------------------------------------------------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
V
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
240
Blastp_CBE
58.21
41%
-35
- C4 -
-
5O49
1
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
----
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
191
Blastp_CBE
58.18
43%
-31
- C4 -
-
4J99
1
?
C:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG----
M
-
E
----------
Y
---------
S
Y
-----
D
-------------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
243
Blastp_CBE
58.16
41%
-31
- C4 -
-
5EW8
1
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG------------------------------------------EE----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
182
Blastp_CBE
58.14
43%
-27
- C4 -
-
4J95
1
FGFR2_HUMAN
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
P--------------------------------------------------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
----
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
58.11
40%
-28
- C4 -
-
5A46
2
B:
[37-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------HNPEE-
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
-------------------------------------------------------------------------------------------------------------------------
181
Blastp_CBE
58.10
43%
-26
- C4 -
-
4J95
1
?
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
P--------------------------------------------------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
175
Blastp_CBE
58.09
40%
-62
- C4 -
-
4PMT
1
A:
[7-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
G
A
F
G
K
V
F
L
A
E
C
H
N
L
-------
D
K
-
M
-
L
-
V
A
V
K
A
L
----------
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
GGEDV----
A
P
-----
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
--
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
244
Blastp_CBE
58.05
41%
-36
- C4 -
-
4V05
3
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
----
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
-----
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
241
Blastp_CBE
57.96
41%
-33
- C4 -
-
5O49
1
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
188
Blastp_CBE
57.96
40%
-52
- C4 -
-
4YPS
1
A:
[14-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
L
-
L
-----
D
K
-
M
-
L
-
V
A
V
K
A
L
---
S
-
E
S
A
R
Q
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
GGEDV----
A
P
-----
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
--
M
S
R
-
D
I
Y
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
H
S
I
K
D
V
H
A
R
L
Q
-----------------------------------------------------------------------------------------------------------------------------------
214
Blastp_CBE
57.95
41%
-37
- C4 -
-
5A4C
7
B:
[15-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
----
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
245
Blastp_CBE
57.93
41%
-37
- C4 -
-
4V05
4
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG------------------------------------------EE----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
236
Blastp_CBE
57.91
41%
-29
- C4 -
-
5ZV2
1
FGFR1_HUMAN
A:
[14-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
--
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
328
Blastp_CBE
57.89
42%
-54
- C4 -
-
5U6C
1
MERTK_HUMAN
A:
[25-306]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
N
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
M
R
L
L
G
V
C
I
-
E
M
---IPKP-
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
238
Blastp_CBE
57.89
41%
-33
- C4 -
-
5O4A
1
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-------------EE----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
362
Blastp_CBE
57.85
42%
-48
- C4 -
-
5JKG
1
A:
[20-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
---
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
GP--------------------------------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
77
Blastp_CBE
57.83
50%
-16
- C4 -
-
2OJ9
1
A:
[17-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
--------------------------------------------------PP-
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
Y
E
T
D
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
219
Blastp_CBE
57.78
41%
-33
- C4 -
-
5AM6
1
FGFR1_HUMAN
A:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG------------------------------------------EE----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
324
Blastp_CBE
57.75
43%
-27
- C4 -
-
5UGX
1
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG----
M
------------------------------INRVPE
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
V
----------
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
230
Blastp_CBE
57.76
41%
-31
- C4 -
-
5Z0S
1
FGFR1_HUMAN
A:
[16-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
235
Blastp_CBE
57.75
41%
-38
- C4 -
-
5ZV2
1
B:
[14-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
--------
D
Y
Y
K
K
T
---
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
400
Blastp_CBE
57.71
41%
-89
- C4 -
-
3QUP
1
A:
[16-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
-
L
I
P
--------
F
T
L
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
Q
L
-------------
V
-
K
-
V
A
V
K
M
L
---
S
S
D
I
E
--
E
-
F
L
R
E
A
A
C
M
K
E
F
-
D
-
H
P
H
V
A
K
L
V
G
V
S
L
-
R
S
---IP---
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
-----
S
R
-------
I
-------------P--------
F
N
-----
L
------
P
------
L
-------
Q
---
T
L
V
R
------
F
M
---
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
-
E
D
M
T
----
V
C
V
A
D
F
G
L
------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
-
R
G
Q
T
P
Y
A
G
I
E
-
N
A
E
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------
253
Blastp_CBE
57.70
41%
-17
- C4 -
-
4UWB
4
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
-------------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
198
Blastp_CBE
57.69
43%
-31
- C4 -
-
2Q0B
1
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
P-------------------------------------PE----
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
239
Blastp_CBE
57.67
41%
-36
- C4 -
-
5O4A
2
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG------------------------------------------EE----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
57.66
42%
-54
- C4 -
-
5K0X
1
MERTK_HUMAN
A:
[25-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
K
L
D
N
S
S
Q
--
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
----PKP--
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
250
Blastp_CBE
57.64
41%
-32
- C4 -
-
4UWC
9
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-------------HNPEE-
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
288
Blastp_CBE
57.63
41%
-25
- C4 -
-
6P68
1
C:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
259
Blastp_CBE
57.59
41%
-35
- C4 -
-
4NK9
5
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
--
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
357
Blastp_CBE
57.48
42%
-86
- C4 -
-
3CD3
3
A:
[114-374]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
--------
L
R
A
D
N
-
T
-
L
-
V
A
V
K
S
C
R
----
P
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
-----
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-----
E
--------------------------------------
G
------
A
------
R
-------
L
---
R
V
K
T
------
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
E
K
N
-----
V
L
K
I
S
D
F
G
M
S
R
-
E
-
E
A
D
G
V
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
-------------------------------------------------------------------------------------------------------------------------------
332
Blastp_CBE
57.48
42%
-47
- C4 -
-
5XFF
1
A:
[20-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
GP--------------------------------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
263
Blastp_CBE
57.47
41%
-36
- C4 -
-
4F64
3
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
336
Blastp_CBE
57.46
42%
-66
- C4 -
-
6MEP
1
MERTK_HUMAN
A:
[25-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
------------E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
------P----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
71
Blastp_CBE
57.44
50%
-22
- C4 -
-
1JQH
1
IGF1R_HUMAN
B:
[18-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
----------------------------------------------------PP-
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
--------
Y
Y
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
256
Blastp_CBE
57.42
41%
-35
- C4 -
-
4NKA
2
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
-------
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
154
Blastp_CBE
57.40
43%
-33
- C4 -
-
2PZ5
1
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
T
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PP------------------------------------------
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
229
Blastp_CBE
57.37
41%
-30
- C4 -
-
5Z0S
1
B:
[16-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
-
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
342
Blastp_CBE
57.33
42%
-58
- C4 -
-
4MHA
1
MERTK_HUMAN
A:
[29-304]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
----PKP--
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
347
Blastp_CBE
57.28
42%
-71
- C4 -
-
3TCP
1
B:
[25-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
K
--------------
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
M
S
S
Q
GIPKP
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
--------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
171
Blastp_CBE
57.20
43%
-6
- C4 -
-
1OEC
1
A:
[24-305]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-----
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
--------------------------------------------
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
312
Blastp_CBE
57.15
40%
-27
- C4 -
-
3GQL
1
C:
[25-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
------------------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
57.13
42%
-27
- C4 -
-
4QRC
1
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
GPDLSPDGPR
S
---------
S
E
-----
G
------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
549
Blastp_CBE
57.11
41%
-76
- C4 -
-
3V5Q
1
NTRK3_HUMAN
A:
[14-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
R
E
L
------
K
V
F
L
A
E
C
Y
N
--
L
S
-
P
T
K
D
K
-
M
-
L
-
V
A
V
K
A
L
--
P
T
L
A
A
R
K
-
D
-
F
Q
R
E
A
E
L
L
T
N
L
-
Q
-
H
E
H
I
V
K
F
Y
G
V
C
G
-
D
G
D
P
L
-----
I
M
V
F
E
Y
M
K
H
G
D
L
N
K
F
L
R
A
--------------------------------------
H
-----
G
------
P
----------------------ELGLSQ
M
L
H
I
A
S
Q
I
A
S
G
M
V
Y
L
A
S
Q
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
A
N
L
L
V
K
I
G
D
F
G
M
---
D
V
Y
S
T
D
Y
Y
R
----
T
M
L
P
I
R
W
M
P
P
E
S
I
M
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
I
L
W
E
I
F
T
-
Y
G
K
Q
P
W
F
Q
L
S
-
N
T
E
V
I
E
C
I
T
Q
-------
G
R
V
L
E
R
P
R
V
C
P
K
E
V
Y
D
V
M
L
G
C
W
Q
R
E
P
Q
Q
R
----------------------------------------------------------------------------------------------------------------------------------------------
574
Fugue
57.05
37%
-6
- C4 -
-
3CD3
3
A:
[1-376]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
I
P
E
V
Q
K
P
L
H
E
Q
L
W
YHGA
I
P
R
A
E
V
A
E
L
L
V
H
S
G
D
F
L
V
R
E
S
Q
E
Y
V
L
S
V
P
R
-----------
H
F
I
I
N
L
Y
R
L
F
P
S
I
P
L
L
I
D
H
L
L
S
T
Q
Q
P
L
S
G
V
V
L
H
R
A
V
P
-
K
D
K
W
V
L
N
-----
H
E
D
L
V
L
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
R
L
--------
R
A
D
N
-
T
-
L
-
V
A
V
K
S
C
R
P
----
D
L
K
A
K
-
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
-
H
P
N
I
V
R
L
I
G
V
C
T
-
Q
K
Q
P
I
-----
Y
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
R
T
-----
E
G
-------
A
-
R
-------------------------------------------------
L
---
R
V
K
T
------
L
L
Q
M
V
G
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
-----
E
K
N
V
L
K
I
S
D
F
G
M
S
R
-
E
E
-
A
D
G
V
A
A
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
-
L
G
A
S
P
Y
P
N
L
S
-
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
I
Y
Q
E
L
Q
S
I
R
K
R
H
-----------------------------------------------------------------------------------------------------------------------------
358
Blastp_CBE
57.10
42%
-52
- C4 -
-
5XFJ
1
A:
[20-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
---
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
M
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
GP--------------------------------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
283
Blastp_CBE
57.09
41%
-41
- C4 -
-
4WUN
1
FGFR1_HUMAN
A:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-----
L
-
E
----------
Y
---------
S
Y
-----
N
------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
297
Blastp_CBE
57.06
41%
-42
- C4 -
-
4RWL
1
B:
[25-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
----
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
286
Blastp_CBE
57.06
41%
-28
- C4 -
-
6P69
2
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
193
Blastp_CBE
57.05
43%
-31
- C4 -
-
4J99
1
FGFR2_HUMAN
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
P--------------------------------------------------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
--
D
Y
Y
K
--
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
185
Blastp_CBE
57.03
43%
-23
- C4 -
-
2PVY
1
?
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG----------------------------------
D
INRVPE
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
--
Y
Y
K
----
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
353
Blastp_CBE
57.02
42%
-68
- C4 -
-
3BPR
1
MERTK_HUMAN
B:
[25-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
K
L
-------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
M
---P----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
S
------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
231
Blastp_CBE
57.00
41%
-33
- C4 -
-
4ZSA
1
B:
[16-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
330
Blastp_CBE
56.99
41%
-25
- C4 -
-
3TT0
1
FGFR1_HUMAN
A:
[66-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-----
N
------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
327
Blastp_CBE
56.97
42%
-44
- C4 -
-
5U6C
1
B:
[26-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
---------
I
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
M
R
L
L
G
V
C
I
-
E
M
S
S
Q
GIPKP
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
--------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
252
Blastp_CBE
56.94
41%
-24
- C4 -
-
4UWB
3
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-------------HNPEE-
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
152
Blastp_CBE
56.86
43%
-29
- C4 -
-
2PZP
1
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
E
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG-----------------------------------E-----
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
155
Blastp_CBE
56.84
43%
-27
- C4 -
-
2PZ5
1
FGFR2_HUMAN
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
T
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
--------------------------------------PE----
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
345
Blastp_CBE
56.83
42%
-85
- C4 -
-
4M3Q
1
B:
[26-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
-----
G
S
V
M
E
G
N
L
K
-------
S
----
L
-
K
-
V
A
V
K
T
M
------------
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
------KP---
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
311
Blastp_CBE
56.80
42%
-45
- C4 -
-
4XCU
1
A:
[14-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
-
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
P
G
----------
S
---------
S
E
-----
G
------
P
------
L
-----------
S
F
P
V
------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
211
Blastp_CBE
56.76
43%
-21
- C4 -
-
3B2T
1
FGFR2_HUMAN
A:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
----
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PP-------------------------------------------------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
258
Blastp_CBE
56.75
41%
-37
- C4 -
-
4NK9
2
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
---------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
246
Blastp_CBE
56.73
41%
-34
- C4 -
-
4V04
6
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
---------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
199
Blastp_CBE
56.72
43%
-26
- C4 -
-
2Q0B
1
FGFR2_HUMAN
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
--------------------------------------PE----
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
153
Blastp_CBE
56.71
43%
-26
- C4 -
-
2PZP
1
FGFR2_HUMAN
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
E
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
--------------------------------------PE----
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
269
Blastp_CBE
56.59
41%
-32
- C4 -
-
6C1O
1
FGFR1_HUMAN
A:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-----------------------------
Y
-----
N
------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
190
Blastp_CBE
56.59
43%
-12
- C4 -
-
4J99
1
?
D:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
---------------------------------------------------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
T
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
299
Blastp_CBE
56.56
41%
-25
- C4 -
-
4RWJ
1
FGFR1_HUMAN
A:
[25-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-----
N
------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
56.55
41%
-32
- C4 -
-
6MZW
1
FGFR1_HUMAN
A:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-----
N
------
P
SPEE--
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
183
Blastp_CBE
56.44
43%
-16
- C4 -
-
2PVY
1
?
D:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG-----------------------------------VPE---
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
248
Blastp_CBE
56.43
41%
-41
- C4 -
-
4V01
6
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
L
A
E
A
I
G
L
-
D
----
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
---------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
222
Blastp_CBE
56.35
41%
-34
- C4 -
-
2FGI
1
FGFR1_HUMAN
A:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
--
D
I
H
H
I
D
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
265
Blastp_CBE
56.33
41%
-35
- C4 -
-
4F63
3
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
56.31
41%
-23
- C4 -
-
6P68
1
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
---
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
282
Blastp_CBE
56.14
41%
-42
- C4 -
-
4WUN
1
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-----
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
227
Blastp_CBE
56.13
41%
-17
- C4 -
-
6ITJ
1
?
B:
[16-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
274
Blastp_CBE
56.11
41%
-45
- C4 -
-
6C19
1
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
210
Blastp_CBE
56.09
43%
-24
- C4 -
-
3B2T
1
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
----
F
G
Q
V
V
M
A
E
A
V
G
I
----
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PP-------------------------------------------------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
334
Blastp_CBE
56.02
42%
-13
- C4 -
-
4UXQ
1
A:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
---------------------------
G
------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
216
Blastp_CBE
56.00
41%
-34
- C4 -
-
5B7V
1
B:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------
D
Y
Y
K
K
T
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
275
Blastp_CBE
55.98
41%
-43
- C4 -
-
6C19
1
FGFR1_HUMAN
A:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------
E
----------
Y
---------
S
Y
-----
N
------
P
SEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
310
Blastp_CBE
55.95
42%
-51
- C4 -
-
6NVG
1
A:
[14-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
-
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
P
G
----------
S
---------
S
E
-----
G
------
P
------
L
-----------
S
F
P
V
------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
509
Blastp_CBE
55.91
41%
-35
- C4 -
-
6IUP
2
?
A:
[31-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
--
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
--PR--------
S
---------
S
E
-----
G
------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
G
V
H
H
I
D
Y
Y
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
511
Blastp_CBE
55.88
41%
-54
- C4 -
-
5I8A
1
A:
[10-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
R
D
I
V
L
K
W
E
L
G
E
---
G
K
V
F
L
A
E
C
H
N
---------
K
-
M
-
L
-
V
A
V
K
A
L
K
---------
D
-
F
Q
R
E
A
E
L
L
T
M
L
-
Q
-
H
Q
H
I
V
R
F
F
G
V
C
T
-
E
G
R
P
L
-----
L
M
V
F
E
Y
M
R
H
G
D
L
N
R
F
L
R
S
HGPD-
A
K
-------
L
-
L
----------
A
---------
G
G
EDVAP
G
------
P
------
L
-----------
G
L
G
Q
------
L
L
A
V
A
S
Q
V
A
A
G
M
V
Y
L
A
G
L
H
F
V
H
R
D
L
A
T
R
N
C
L
V
G
-----
Q
G
L
V
V
K
I
G
D
F
G
-
S
R
-
D
I
-
S
T
D
Y
Y
R
V
---
T
M
L
P
I
R
W
M
P
P
E
S
I
L
Y
R
K
F
T
T
E
S
D
V
W
S
F
G
V
V
L
W
E
I
F
T
-
Y
G
K
Q
P
W
Y
Q
L
S
-
N
T
E
A
I
D
C
I
T
Q
-------
G
R
E
L
E
R
P
R
A
C
P
P
E
V
Y
A
I
M
R
G
C
W
Q
R
E
P
Q
Q
R
---
H
S
I
K
D
--------------------------------------------------------------------------------------------------------------------------------------
184
Blastp_CBE
55.91
43%
-20
- C4 -
-
2PVY
1
?
C:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
------
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG----
M
-
E
----------------------------VPE---
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
--
Y
Y
K
---
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
218
Blastp_CBE
55.89
41%
-40
- C4 -
-
5AM6
1
B:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
--------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
307
Blastp_CBE
55.88
42%
-53
- C4 -
-
6NVJ
1
A:
[14-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
-
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
P
G
----------
S
---------
S
E
-----
G
------
P
------
L
-----------
S
F
P
V
------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
314
Blastp_CBE
55.84
40%
-23
- C4 -
-
3GQL
1
FGFR1_HUMAN
A:
[25-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
N
Q
E
Y
------------------------------------------------------------------------------------------------------------------------
165
Blastp_CBE
55.82
43%
-12
- C4 -
-
4J97
1
?
D:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
-----
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PP------------------------------------RVPE--
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
279
Blastp_CBE
55.77
41%
-32
- C4 -
-
5UR1
1
FGFR1_HUMAN
A:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-----------------------------
Y
-----
N
------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
247
Blastp_CBE
55.72
41%
-16
- C4 -
-
4V04
6
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
-------------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
---------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
237
Blastp_CBE
55.69
41%
17
- C4 -
-
4K33
1
A:
[25-314]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
A
D
P
KWELS
R
A
R
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
I
G
I
D
K
D
-
R
A
A
K
P
-
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
D
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
G
G
P
L
-----
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
PPGLDYS
F
-
D
----------
T
---------
S
--------------E-----
Q
-------
L
---
T
F
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
V
H
N
L
D
Y
Y
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
339
Blastp_CBE
55.66
42%
-60
- C4 -
-
5K0K
1
B:
[26-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
--
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
----------------
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
M
S
S
Q
GIPKP
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
200
Blastp_CBE
55.66
43%
-21
- C4 -
-
5UHN
2
B:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
H
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
---------------------------------------------------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
344
Blastp_CBE
55.64
42%
-63
- C4 -
-
4MH7
1
MERTK_HUMAN
A:
[26-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
-----------------
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
M
S
S
Q
GIPKP
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
270
Blastp_CBE
55.61
41%
-44
- C4 -
-
6C1C
1
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
226
Blastp_CBE
55.58
41%
-32
- C4 -
-
1AGW
1
FGFR1_HUMAN
A:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
217
Blastp_CBE
55.58
41%
-24
- C4 -
-
5B7V
1
FGFR1_HUMAN
A:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
249
Blastp_CBE
55.52
41%
-40
- C4 -
-
4V01
6
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
---------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
399
Blastp_CBE
55.43
41%
-90
- C4 -
-
4FEQ
1
A:
[22-294]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
F
T
L
G
R
M
L
G
K
---
G
S
V
R
E
A
Q
L
K
---
D
G
----
S
F
-
V
-
K
-
V
A
V
K
M
L
------------
F
L
R
E
A
A
C
M
K
E
F
-
D
-
H
P
H
V
A
K
L
V
G
V
S
-------P----
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
-----
S
R
-------
I
------------------------------------
P
------
L
-------
Q
---
T
L
V
R
------
F
M
---
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
-
E
D
M
T
----
V
C
V
A
D
F
G
---------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
-
R
G
Q
T
P
Y
A
G
I
E
-
N
A
E
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
L
R
M
E
L
E
-----------------------------------------------------------------------------------------------------------------------------------
179
Blastp_CBE
55.30
43%
-16
- C4 -
-
4J95
2
?
D:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
---------------------------------------------------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
-----------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
180
Blastp_CBE
55.25
43%
-4
- C4 -
-
4J95
1
?
C:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
---------------------------------------------------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
N
N
I
D
Y
Y
K
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
213
Blastp_CBE
55.24
41%
-16
- C4 -
-
5AM7
1
FGFR1_HUMAN
A:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
H
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
278
Blastp_CBE
55.17
41%
-42
- C4 -
-
5UR1
1
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
298
Blastp_CBE
55.16
41%
-34
- C4 -
-
4RWJ
1
B:
[25-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
----------
Y
K
K
T
T
-
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
323
Blastp_CBE
55.14
41%
-36
- C4 -
-
6NVL
1
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
---------
Y
Y
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
147
Blastp_CBE
55.12
42%
-43
- C4 -
-
2IVT
3
A:
[20-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-----
S
R
-------
K
-
V
-----------------------------------R-----
A
-------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
Y
E
E
D
S
V
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
295
Blastp_CBE
55.11
41%
-20
- C4 -
-
4RWK
1
B:
[25-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------
I
D
Y
Y
K
K
T
--
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
141
Blastp_CBE
55.10
42%
-42
- C4 -
-
4CKJ
16
A:
[20-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-----
S
R
-------
K
-
V
-----------------------------------R-----
A
-------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
Y
E
E
D
S
V
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
308
Blastp_CBE
55.07
42%
-50
- C4 -
-
6NVI
1
A:
[14-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
-
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
P---------------------
S
E
-----
G
------
P
------
L
-----------
S
F
P
V
------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
G
V
-------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
143
Blastp_CBE
55.08
42%
-48
- C4 -
-
2X2M
3
RET_HUMAN
A:
[20-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
--
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-----
S
----------------------------------------------R-----
A
-------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
Y
E
E
D
S
V
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
271
Blastp_CBE
55.07
41%
-31
- C4 -
-
6C1C
1
FGFR1_HUMAN
A:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP----------------------------
S
Y
-----
N
------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
309
Blastp_CBE
55.03
42%
-55
- C4 -
-
6NVH
1
A:
[14-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
-
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
P
G
----------
S
---------
S
E
-----
G
------
P
------
L
-----------
S
F
P
V
------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
----------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
277
Blastp_CBE
55.01
41%
-33
- C4 -
-
6C18
1
FGFR1_HUMAN
A:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG---------------------------
S
Y
-----
N
------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
306
Blastp_CBE
54.98
42%
-50
- C4 -
-
6NVK
1
A:
[14-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
G
R
-
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
P
G
----------
S
---------
S
E
-----
G
------
P
------
L
-----------
S
F
P
V
------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
145
Blastp_CBE
54.98
42%
-46
- C4 -
-
2X2K
4
A:
[20-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-----
S
R
-------
K
-
V
-----------------------------------R-----
A
-------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
Y
E
E
D
S
V
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
341
Blastp_CBE
54.95
42%
-61
- C4 -
-
4MHA
1
B:
[26-304]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
--------------------
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
M
S
S
Q
GIPKP
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
131
Blastp_CBE
54.94
48%
-36
- C4 -
-
4XLV
1
?
A:
[38-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
E
T
D
---
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
215
Blastp_CBE
54.93
41%
-18
- C4 -
-
5A4C
6
FGFR1_HUMAN
A:
[15-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-----
N
------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
355
Blastp_CBE
54.83
42%
-56
- C4 -
-
2P0C
1
B:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
---
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
-----------E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
-------IPKP-
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
322
Blastp_CBE
54.83
41%
-47
- C4 -
-
6NVL
1
FGFR1_HUMAN
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
-------
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
260
Blastp_CBE
54.76
41%
-37
- C4 -
-
4F65
4
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
----
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
--------
H
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
255
Blastp_CBE
54.74
41%
-38
- C4 -
-
4NKS
1
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
---------
N
R
-
V
T
K
-
V
A
V
K
M
L
K
-
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
-------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
573
Fugue
54.72
43%
-30
- C4 -
-
1IR3
1
A:
[4-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
V
F
V
P
---
D
E
W
E
V
S
-----
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K-
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
PEA----
E
-
N
----------
N
---------
P
G
-----
R
------
P
------
P
-------
P
---
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-----
H
D
F
T
V
K
I
G
D
F
G
M
T
-R
D
I
E
T
D
R
K
G
G
K
G
---
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
N-
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
D
D
L
H
P
S
F
P
E
V
S
F
F
H
S
E
E
N
K
----------------------------------------------------------------------------------------------------------------
129
Blastp_CBE
54.68
48%
-37
- C4 -
-
1IR3
1
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
E
T
D
---
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
54.67
41%
-19
- C4 -
-
4TYI
1
A:
[20-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
----------------------------------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-
G
--------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
101
Blastp_CBE
54.65
48%
-40
- C4 -
-
3BU5
1
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
---
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
E
T
D
---
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
257
Blastp_CBE
54.64
41%
-20
- C4 -
-
4NKA
3
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
----
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
--------
I
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
267
Blastp_CBE
54.50
41%
-26
- C4 -
-
6MZQ
1
FGFR1_HUMAN
A:
[19-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-----
N
------
P
SEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
273
Blastp_CBE
54.41
41%
-38
- C4 -
-
6C1B
1
FGFR1_HUMAN
A:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
356
Blastp_CBE
54.38
42%
-58
- C4 -
-
2P0C
2
MERTK_HUMAN
A:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
--
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
-----------E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
-------IPKP-
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
G
L
-------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
132
Blastp_CBE
54.36
48%
-54
- C4 -
-
1K3A
1
A:
[9-275]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
M
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
V
A
K
G
V
-
V
K
--
D
E
P
E
-
T
-
R
-
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
-
Q
G
Q
P
T
-----
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
M
---------------------------------------P--
S
L
S
K
------
M
I
Q
M
A
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
E
T
D
---
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
I
----------------------------------------------------------------------------------------------------------------------------------------
151
Blastp_CBE
54.27
41%
-53
- C4 -
-
4CKI
8
A:
[20-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-----
S
R
-------
K
-
V
-----------------------------------DER---
A
-------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
E
E
D
S
V
Y
-
K
R
S
Q
G
R
I
P
V
K
W
T
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
401
Blastp_CBE
54.20
41%
-26
- C4 -
-
5NWZ
1
B:
[16-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
----------------------------------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
------------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
321
Blastp_CBE
54.19
41%
-37
- C4 -
-
6NVL
1
FGFR1_HUMAN
C:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
-
D
----
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
--
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
-----
H
H
I
D
Y
Y
K
K
T
-----
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
392
Blastp_CBE
54.11
42%
-22
- C4 -
-
4QQ5
1
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-------
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
---------------------------
G
------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
149
Blastp_CBE
54.08
42%
-40
- C4 -
-
6NJA
2
A:
[20-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
-----
S
R
-------
K
-
V
-----------------------------------ER----
A
-------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
E
E
D
S
V
Y
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
391
Blastp_CBE
53.96
42%
-20
- C4 -
-
4R6V
1
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-------
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
L
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
---------------------------
G
------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------------------
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
212
Blastp_CBE
53.96
41%
-10
- C4 -
-
5AM7
1
B:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
284
Blastp_CBE
53.83
41%
-10
- C4 -
-
3RHX
2
B:
[14-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
403
Blastp_CBE
53.78
41%
-21
- C4 -
-
5NUD
1
B:
[16-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
----------------------------------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
-------------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
346
Blastp_CBE
53.73
42%
-65
- C4 -
-
4M3Q
1
MERTK_HUMAN
A:
[27-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
-------------------
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
M
S
S
Q
GIPKP
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
---------------------
P
V
K
W
I
A
I
E
S
L
--
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
510
Blastp_CBE
53.72
41%
-17
- C4 -
-
6IUO
1
?
A:
[31-312]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
----
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
---------------------------
G
------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
491
Blastp_CBE
53.68
41%
-21
- C4 -
-
4QQC
1
A:
[32-313]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
R
A
E
A
F
G
M
-------
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
-
P
---------------------------
G
------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
130
Blastp_CBE
53.67
48%
-39
- C4 -
-
1GAG
1
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
E
T
D
---
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
223
Blastp_CBE
53.65
41%
-14
- C4 -
-
1FGI
1
B:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
221
Blastp_CBE
53.65
41%
-15
- C4 -
-
2FGI
1
B:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
261
Blastp_CBE
53.63
41%
-22
- C4 -
-
4F65
5
FGFR1_HUMAN
A:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PP-------------------------------------------PEE---
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
-----------
Y
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
337
Blastp_CBE
53.45
42%
-40
- C4 -
-
5K0X
1
B:
[24-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
--
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
------------E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
-
E
M
S
S
Q
GIPKP
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
331
Blastp_CBE
53.42
42%
-58
- C4 -
-
5TC0
1
MERTK_HUMAN
A:
[28-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
--------------------
M
K
D
F
-
S
-
H
P
N
V
M
R
L
L
G
V
C
I
-
E
M
S
S
Q
GIPKP
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
--------------------
M
P
V
K
W
I
A
I
E
-------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
106
Blastp_CBE
53.42
48%
-41
- C4 -
-
1RQQ
1
B:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
E
T
D
---
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
262
Blastp_CBE
53.29
41%
-15
- C4 -
-
4F64
3
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
281
Blastp_CBE
53.27
41%
-38
- C4 -
-
5UQ0
1
FGFR1_HUMAN
A:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------E-----
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
-
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
107
Blastp_CBE
53.25
48%
-41
- C4 -
-
1RQQ
1
INSR_HUMAN
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
E
T
D
---
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
268
Blastp_CBE
53.19
41%
-40
- C4 -
-
6C1O
1
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
--
F
G
Q
V
V
L
A
E
A
I
G
L
-----
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
-------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
150
Blastp_CBE
53.14
41%
-40
- C4 -
-
6NE7
2
A:
[20-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
Y
A
S
L
R
G
F
L
R
E
-----
S
R
-------
K
-
V
---------------------------
G
-------ER----
A
-------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
E
E
D
S
V
Y
-
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
335
Blastp_CBE
53.08
42%
-46
- C4 -
-
6MEP
1
B:
[27-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
-
V
I
D
-----
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
-----------------
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
-------P----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
--
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
318
Blastp_CBE
52.84
41%
-40
- C4 -
-
6MZW
1
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
-----
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
P--------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
---------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
393
Blastp_CBE
52.70
41%
-25
- C4 -
-
4TYJ
2
A:
[20-301]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
------------------------------------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
----------------
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
329
Blastp_CBE
52.40
41%
-10
- C4 -
-
3TT0
4
B:
[66-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
272
Blastp_CBE
52.30
41%
-8
- C4 -
-
6C1B
1
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
----------
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
225
Blastp_CBE
52.20
41%
-12
- C4 -
-
1AGW
1
B:
[18-299]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
264
Blastp_CBE
52.16
41%
-5
- C4 -
-
4F63
3
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
128
Blastp_CBE
52.07
48%
-30
- C4 -
-
2Z8C
1
A:
[13-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
E
K
I
T
L
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
N
A
R
D
I
-
I
K
--
G
E
A
E
-
T
-
R
-
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
-
K
G
Q
P
T
-----
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
-----
L
R
-------
P
-
E
----------
A
---------
E
N
-----
N
------
P
------
G
-------
R
PPP
T
L
Q
E
------
M
I
Q
M
A
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
-
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
-
D
I
E
T
D
---
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
-
L
A
E
Q
P
Y
Q
G
L
S
-
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
I
V
N
L
L
K
-----------------------------------------------------------------------------------------------------------------------------------
266
Blastp_CBE
51.89
41%
-11
- C4 -
-
6MZQ
1
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
-
D
K
-
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
------------------------------------------------------------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
51.55
41%
-19
- C4 -
-
6NVL
1
D:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
--------
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
--
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
---
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
PPG----
L
-
E
----------
Y
---------
S
Y
-----
N
------
P
SHNPEE
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
----------
Y
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
254
Blastp_CBE
51.55
41%
-5
- C4 -
-
4NKS
1
B:
[17-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
E
A
I
G
L
------
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
A
-------
D
Y
Y
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
404
Blastp_CBE
51.16
41%
-18
- C4 -
-
5NUD
1
FGFR4_HUMAN
A:
[16-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
G
--
G
Q
V
V
R
A
E
A
F
G
M
-
D
P
-
A
R
P
D
Q
-
A
-
S
T
V
A
V
K
M
L
K
D
N
A
S
D
K
D
L
A
D
-
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
-
Q
E
G
P
L
-----
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
-----
R
R
-------
P
------------------------------------
P
------
L
-------
S
---
F
P
V
-------
L
V
S
C
A
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
------------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
K
Q
L
V
E
A
L
------------------------------------------------------------------------------------------------------------------------------------
276
Blastp_CBE
51.07
41%
-11
- C4 -
-
6C18
1
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
----
G
Q
V
V
L
A
E
A
I
G
L
----
D
K
P
N
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
---------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
326
Blastp_CBE
50.84
43%
-43
- C4 -
-
5TD2
1
MERTK_HUMAN
A:
[8-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
L
L
I
L
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
N
L
K
Q
E
-
D
G
-
T
S
----
L
-
K
-
V
A
V
K
T
M
----------------
A
A
C
M
K
D
F
-
S
-
H
P
N
V
M
R
L
L
G
V
C
I
-
E
M
S
S
-P----
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
-----
S
R
-------
L
-
E
----------
T
----------------
G
------
P
------
K
H------
I
---
P
L
Q
T
------
L
L
K
F
M
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
-
D
D
M
T
----
V
C
V
A
D
F
---------------------
P
V
K
W
I
A
I
E
S
L
----
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
-
R
G
M
T
P
Y
P
G
V
Q
-
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
L
R
L
Q
L
E
-----------------------------------------------------------------------------------------------------------------------------------
280
Blastp_CBE
50.31
41%
-10
- C4 -
-
5UQ0
1
B:
[19-300]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
-----
R
D
R
L
V
L
G
K
P
L
G
E
---
G
Q
V
V
L
A
E
A
I
G
L
--------
R
-
V
T
K
-
V
A
V
K
M
L
K
S
D
A
T
E
K
D
L
S
D
-
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
-----
R
R
---------------------------------------------------
Q
-------
L
---
S
S
K
D
------
L
V
S
C
A
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
D
N
V
M
K
I
A
D
F
G
L
------------------
L
P
V
K
W
M
A
P
E
A
L
--
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
V
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
49.87
41%
-48
- C4 -
-
2PVF
1
A:
[32-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
---
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
PPG----
M
-
E
----------
S
---------
Y
D
---------------------------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
--
N
N
I
D
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
E
E
-------------------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
48.59
41%
-25
- C4 -
-
3CLY
1
FGFR2_HUMAN
A:
[32-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
--------------------------------------E-----
E
------
Q
-------
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
--
N
N
I
D
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
D
R
I
L
T
L
T
T
N
E
E
Y
------------------------------------------------------------------------------------------------------------------------
206
Blastp_CBE
48.48
42%
-54
- C4 -
-
5FM3
1
A:
[61-348]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
K
N
L
V
L
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
T
A
F
H
L
-
K
G
-
R
-
A
G
Y
-
T
-
T
-
V
A
V
K
M
L
K
E
N
A
S
P
S
E
L
R
D
-
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
-
Q
D
G
P
L
-----
L
L
I
V
E
Y
A
K
G
S
-
L
R
G
F
L
R
E
-----
S
R
-----------------------------------------------------------
L
---
T
M
G
D
------
L
I
S
F
A
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
-----
E
G
R
K
M
K
I
S
D
F
G
L
S
R
-
D
V
Y
E
E
D
S
V
K
R
Q
G
R
--
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
-
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
-
L
G
G
N
P
Y
P
G
I
P
-
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
I
S
K
D
L
E
-----------------------------------------------------------------------------------------------------------------------------------
523
Blastp_CBE
47.60
41%
-4
- C4 -
-
6AGX
1
?
C:
[10-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
-------
P
--------------------------------------------NRVPEEQ
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
--
N
---
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
525
Blastp_CBE
46.93
41%
-3
- C4 -
-
6AGX
1
FGFR2_HUMAN
A:
[10-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
-------
P
-------------------------------------------
I
NRVPEEQ
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
--
N
---
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
524
Blastp_CBE
46.57
41%
-25
* C4 *
-
6AGX
1
B:
[10-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
-------
P
-
P
----------
G
---------
M
E
-----
S
------
D
------
I
NRVPEEQ
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
--
N
N
I
D
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
522
Blastp_CBE
46.49
41%
-26
- C4 -
-
6AGX
1
?
D:
[10-291]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
-----
R
D
K
L
T
L
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
E
A
V
G
I
-
D
K
-
D
K
P
K
E
A
V
-
T
-
V
A
V
K
M
L
K
D
D
A
T
E
K
D
L
S
D
-
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
-
Q
D
G
P
L
-----
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
R
A
-----
R
R
-------
P
-
P
----------
G
---------
M
E
-----
S
------
D
------
I
NRVPEEQ
M
---
T
F
K
D
------
L
V
S
C
T
Y
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
T
A
R
N
V
L
V
-----
T
E
N
N
V
M
K
I
A
D
F
G
L
A
R
-
D
I
--
N
N
I
D
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
-
L
G
G
S
P
Y
P
G
I
P
-
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
L
V
E
D
L
------------------------------------------------------------------------------------------------------------------------------------
-
* C *
-
-
:
----------------------------------------------------------------------------------------------------