@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : SGK3_HUMAN: (2020-09-21 )
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL
Atome Classification :
(439 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150......-.160.......170........180-...---.---.----....190....-...-200.......210..--..-..-.220.......230..-.....240.......250..-.....260.......270.......-280........290.....-..300.......310--.....-..--..----320.......330....-----.-..340.......350......-.360.....---..370---------.-..--...----.380.-----..---......390.......400--..-.-.--.--.-.410.--.......420.---......430.......440.......450.......460.......470.......480.....---..490....
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MQRDHTM
D
Y
K
ESCPSVSIPSS
D
E
H
R
E
K
K
K
R
F
T
V
Y
K
V
L
V
S
VGRS
E
W
F
V
F
R
R
Y
A
E
F
D
K
L
Y
N
T
L
K
K
QFPA
M
A
L
KI
P
A
K
R
IFGDNF
D
P
D
F
I
K
Q
R
R
A
G
L
N
E
F
I
Q
N
L
V
RY
P
E
LYNHP
D
V
R
A
F
L
QMDSPKHQSDPSE
D
E
D
E
R
S
S
Q
K
LHSTSQNINLGPSGNPHAK-PT
D
F
D
F
L
K
V
IGKG-SFG
K
V
L
L
A
K---RKL---D---G----
K
F
Y
A
V
K
V
L
Q
K
K
-
I
VL-N
R
K
E
Q
K
H
I
M
A
E
R
N
V
L
--
L
K
-NV-KH
P
F
L
V
G
L
H
Y
S
FQT
T
E
-
K
L
Y
F
V
L
D
FVNGG
E
L
F
F
H
L
Q
R
-ERS
F
P
E
H
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
I
K
-
I
V
YRDLKPE
N
I
L
L
DSV-GH
V
V
L
T
D
F
GLCKE----GIAIS-DT--TT----TFCG
T
P
E
Y
L
A
P
E
V
I
RKQ-----P-YDN
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
YGL-
P
P
F
Y
C
R
D
V
A
---
E
M
Y
D
N
---------
I
-
L
H--KPL----SL--R-----PG---VS
L
T
A
W
S
I
L
E
E
L
L
E
K
D
R
Q
N--RL-G-A--
K
--
E
-
D
F
L
-
E
--IQNHPFFESL
S
---
W
A
D
L
V
Q
K
KIPPPFNPNVA
G
P
D
D
I
R
N
F
D
T
AFTEETV
P
Y
S
V
C
VSSDY
S
I
V
N
A
S
V
LEADD
A
F
V
GFSY---APPSEDLFL
1
PsiBlast_PDB
88.29
72%
-143
- C1 -
-
2R5T
1
SGK1_HUMAN
A:
[24-320]
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
N
L
G
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
K
A
---
E
---
E
----
V
F
Y
A
V
K
V
L
Q
K
K
-
A
I
L
--------------
V
L
--
L
K
-
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
K
E
----
N
I
E
H
N
-
S
T
--
T
S
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
-----
P
-
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
Y
S
R
N
T
A
---
E
M
Y
D
N
---------
I
-
L
N
--
K
P
L
----
Q
L
--
K
-----
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
-
A
--
K
--
D
-
D
F
M
-
E
--
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------------
551
HHSearch
87.04
73%
-140
- C1 -
-
2R5T
1
SGK1_HUMAN
A:
[28-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
K
A
---
E
---
E
----
V
F
Y
A
V
K
V
L
Q
K
K
-
A
I
L
--------------
V
L
--
L
K
-
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
K
E
----
N
I
E
H
N
-
S
T
--
T
S
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
-----
P
-
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
Y
S
R
N
T
A
---
E
M
Y
D
N
---------
I
-
L
N
--
K
P
L
----
Q
L
--
K
-----
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
-
A
--
K
--
D
-
D
F
M
-
E
--
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------------
2
PsiBlast_PDB
85.72
72%
-132
- C1 -
-
3HDM
1
SGK1_HUMAN
A:
[23-320]
------------------------------------------------------------------------------------------------------------------------------------------------
Q
Q
I
N
L
G
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
K
A
---
E
---
E
----
V
F
Y
A
V
K
V
L
Q
K
K
-
A
I
L
--------------
V
L
--
L
K
-
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
K
E
----
N
I
E
H
N
-
S
T
--
T
S
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
-----
P
-
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
Y
S
R
N
T
A
---
E
M
Y
D
N
---------
I
-
L
N
--
K
P
L
----
Q
L
--
K
-----
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
-
A
--
K
--
D
-
D
F
M
-
E
--
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------------
3
PsiBlast_PDB
84.38
72%
-143
- C1 -
-
3HDN
1
SGK1_HUMAN
A:
[24-316]
-------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
N
L
G
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
K
A
---
E
---
E
----
V
F
Y
A
V
K
V
L
Q
K
K
-
A
I
L
--------------
V
L
--
L
K
-
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
K
E
----
N
I
E
H
N
-
S
T
--
T
S
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
-----
P
-
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
Y
S
R
N
T
A
---
E
M
Y
D
N
---------
I
-
L
N
--
K
P
L
----
Q
L
--
K
-----
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
-
A
--
K
--
D
-
D
F
M
-
E
--
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
-------------------------------------------------------------
550
HHSearch
84.25
73%
-131
- C1 -
-
3HDM
1
SGK1_HUMAN
A:
[28-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------
G
P
S
S
N
P
H
A
K
-
P
S
D
F
H
F
L
K
V
I
G
K
G
-
S
F
G
K
V
L
L
A
R
---
H
K
A
---
E
---
E
----
V
F
Y
A
V
K
V
L
Q
K
K
-
A
I
L
--------------
V
L
--
L
K
-
N
V
-
K
H
P
F
L
V
G
L
H
F
S
F
Q
T
A
D
-
K
L
Y
F
V
L
D
Y
I
N
G
G
E
L
F
Y
H
L
Q
R
-
E
R
C
F
L
E
P
R
A
R
F
Y
A
A
E
I
A
S
A
L
G
Y
L
H
S
-
L
N
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
S
Q
-
G
H
I
V
L
T
D
F
G
L
C
K
E
----
N
I
E
H
N
-
S
T
--
T
S
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
H
K
Q
-----
P
-
Y
D
R
T
V
D
W
W
C
L
G
A
V
L
Y
E
M
L
Y
G
L
-
P
P
F
Y
S
R
N
T
A
---
E
M
Y
D
N
---------
I
-
L
N
--
K
P
L
----
Q
L
--
K
-----
P
N
---
I
T
N
S
A
R
H
L
L
E
G
L
L
Q
K
D
R
T
K
--
R
L
-
G
-
A
--
K
--
D
-
D
F
M
-
E
--
I
K
S
H
V
F
F
S
L
I
N
---
W
D
D
L
I
N
K
K
I
T
P
P
F
N
P
N
V
S
G
---------------------------------------------------------
553
HHSearch
79.18
48%
-91
- C1 -
-
2JDO
2
AKT2_HUMAN
A:
[7-341]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
-
M
N
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
R
K
E
-
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
---
Q
-
N
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
S
D
G
-
A
T
--
M
K
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
R
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
P-
S
-
D
A
K
-
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
---------------------
M
F
E
D
F
D
Y
---
I
A
D
------
549
HHSearch
78.08
41%
-106
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[3-329]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
K
K
---
T
---
N
----
Q
F
F
A
I
K
A
L
K
K
D
-
V
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
N
M
L
G
D
-
A
K
--
T
N
----
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
-
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
G
Q
D
E
E
---
E
L
F
H
S
---------
I
-
R
M
--
D
N
P
----
F
Y
--
P
-----
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
------
G
-
D
--
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
K
P
R
L
S
F
A
D
R
A
L
------
I
N
S
M
D
Q
N
M
F
R
N
F
S
F
---
M
N
P
G
M
E
---
19
PsiBlast_PDB
77.70
50%
-93
- C1 -
-
1O6L
1
AKT2_HUMAN
A:
[6-326]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
R
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
R
K
E
-
V
I
I
-
A
K
D
E
V
A
H
T
V
T
E
S
R
V
L
---
Q
-
N
T
-
R
H
P
F
L
T
A
L
K
Y
A
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
T
E
E
R
A
R
F
Y
G
A
E
I
V
S
A
L
E
Y
L
H
S
-
R
D
-
V
V
Y
R
D
I
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
S
D
G
-
A
T
--
M
K
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
R
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
S
P
E
A
K
S
L
L
A
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
P-
S
-
D
A
K
-
E
--
V
M
E
H
R
F
F
L
S
I
N
---
W
Q
D
V
V
Q
K
K
L
L
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
D
E
F
T
A
Q
S
I
T
I
T
--------------------------------------
561
HHSearch
76.63
48%
-38
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[7-337]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
N
R
V
L
---
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
-
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
D
G
-
A
T
--
M
K
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
S-
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
-----
S
M
E
C
--
V
D
S
E
R
R
P
H
F
P
Q
F
D
Y
---
S
A
S
------
27
Blastp_CBE
76.38
50%
0
- C- -
-
3CQW
1
AKT1_HUMAN
A:
[6-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
-
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
26
Blastp_CBE
76.38
50%
0
- C- -
-
3MV5
1
AKT1_HUMAN
A:
[6-327]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
-
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
52
Blastp_CBE
76.32
51%
0
- C- -
-
6NPZ
2
AKT1_HUMAN
A:
[27-340]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
51
Blastp_CBE
76.32
51%
0
- C- -
-
6NPZ
1
AKT1_HUMAN
B:
[27-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
49
Blastp_CBE
76.32
51%
0
- C- -
-
3OCB
1
AKT1_HUMAN
B:
[10-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
48
Blastp_CBE
76.32
51%
0
- C- -
-
3OW4
1
AKT1_HUMAN
A:
[10-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
47
Blastp_CBE
76.32
51%
0
- C- -
-
3OW4
1
AKT1_HUMAN
B:
[10-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
46
Blastp_CBE
76.32
51%
0
- C- -
-
3QKK
1
AKT1_HUMAN
A:
[10-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
45
Blastp_CBE
76.32
51%
0
- C- -
-
3QKL
1
AKT1_HUMAN
A:
[10-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
44
Blastp_CBE
76.32
51%
0
- C- -
-
3QKM
1
AKT1_HUMAN
A:
[10-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
43
Blastp_CBE
76.32
51%
0
- C- -
-
4EKK
1
AKT1_HUMAN
A:
[10-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
572
Fugue
75.72
34%
-43
- C1 -
-
4AW2
5
MRCKA_RAT
A:
[1-416]
--------------------
S
G
E
V
R
L
R
Q
L
E
Q
F
I
L
D
-------------------------------------
G
P
A
Q
T
N
G
Q
C
F
S
V
E
T
L
L
D
I
L
I
C
L
Y
D
E
C
N
N
--------------------
S
P
L
R
R
E
K
N
I
L
E
Y
L
E
W
A
K
P
F
T
S
K
V
K
Q
M
---------
R
L
H
-
R
E
D
F
E
I
L
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
L
K
N
---
A
---
D
----
K
V
F
A
M
K
I
L
N
K
W
-
E
M
L
-
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
--
V
N
-
G
--
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
-
N
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
R
L
P
E
E
M
A
R
F
Y
L
A
E
M
V
I
A
I
D
S
V
H
Q
-
L
H
-
Y
V
H
R
D
I
K
P
D
N
I
L
M
D
M
N
-
G
H
I
R
L
A
D
F
G
S
C
L
K
LMED
G
T
V
Q
S
-
S
V
--
A
V
-------
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
EGGKG
R
-
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
Y
A
E
S
L
V
---
E
T
Y
G
K
---------
I
-
M
N
--
H
K
E
----
R
F
--
Q
FPTQV
T
D
---
V
S
E
N
A
K
D
L
I
R
R
L
I
-
C
S
R
E
H
--
R
L
-
G
----
Q
--
N
-
G
I
E
-
D
--
F
K
K
H
P
F
F
S
G
I
D
---
W
D
N
I
R
N
--
C
E
A
P
Y
I
P
E
V
S
S
P
T
D
T
S
N
F
D
-------------
V
D
S
G
H
H
----------
L
P
F
V
G
F
T
Y
TSS
C
V
L
S
D
R
S
C
L
554
HHSearch
74.72
43%
-81
- C1 -
-
3TXO
1
KPCL_HUMAN
A:
[23-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
---
V
K
E
---
T
---
G
----
D
L
Y
A
V
K
V
L
K
K
D
-
V
I
L
-
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
--
S
L
-
A
R
-
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
-
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
-
G
H
C
K
L
A
D
F
G
M
C
K
E
----
G
I
----------------
C
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
-----
L
-
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
-
A
P
F
E
A
E
N
E
D
---
D
L
F
E
A
---------
I
-
L
N
--
D
E
V
----
V
Y
--
P
-----
T
W
---
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
-
G
-
S
--
L
TQ
G
-
G
E
H
-
A
--
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
P
V
L
T
P
I
D
E
G
------
H
L
P
M
I
N
Q
D
E
F
R
N
F
E
Y
---
V
S
P
------
110
Blastp_CBE
73.60
44%
-75
- C1 -
-
5F9E
1
KPCT_HUMAN
A:
[15-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
K
K
---
T
---
N
----
Q
F
F
A
I
K
A
L
K
K
D
-
V
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
N
M
L
G
D
-
A
K
--
T
N
----
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
-
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
G
Q
D
E
E
---
E
L
F
H
S
---------
I
R
M
D
--
N
P
F
----
Y
P
--
R
------
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
-------------------------------------------
20
PsiBlast_PDB
73.60
49%
-35
- C1 -
-
3CQU
1
AKT1_HUMAN
A:
[6-325]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
-
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
D
G
-
A
T
--
M
K
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
552
HHSearch
72.68
41%
-125
- C1 -
-
1XJD
1
A:
[16-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
K
K
---
T
---
N
----
Q
F
F
A
I
K
A
L
K
K
D
-
V
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
N
M
L
G
D
-
A
K
--
T
N
----
T
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
-
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
G
Q
D
E
E
---
E
L
F
H
S
---------
I
-
R
M
--
D
N
P
----
F
Y
--
P
-----
R
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
------
G
-
D
--
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
--------------------------------------------
Q
N
M
F
R
N
F
S
F
------------
555
HHSearch
72.65
45%
-64
- C1 -
-
5LI9
13
KPCI_HUMAN
A:
[4-343]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
T
--
T
S
----
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
------TED
Y
L
F
Q
V
---------
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
--
H
PQ
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
------
R
K
I
D
Q
S
E
F
E
G
F
E
Y
---
I
N
P
L
L
----
57
Blastp_CBE
72.48
45%
-3
- C1 -
-
4L45
1
KS6B1_HUMAN
A:
[10-346]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
---
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
-
P
V
------------
E
S
---
A
N
Q
V
F
L
G
F
E
Y
---
V
A
P
S
-----
86
Blastp_CBE
72.34
42%
-82
- C1 -
-
3TXO
1
KPCL_HUMAN
A:
[23-349]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
F
E
F
I
R
V
L
G
K
G
-
S
F
G
K
V
M
L
A
R
---
V
K
E
---
T
---
G
----
D
L
Y
A
V
K
V
L
K
K
D
-
V
I
L
-
Q
D
D
D
V
E
C
T
M
T
E
K
R
I
L
--
S
L
-
A
R
-
N
H
P
F
L
T
Q
L
F
C
C
F
Q
T
P
D
-
R
L
F
F
V
M
E
F
V
N
G
G
D
L
M
F
H
I
Q
K
-
S
R
R
F
D
E
A
R
A
R
F
Y
A
A
E
I
I
S
A
L
M
F
L
H
D
-
K
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
H
E
-
G
H
C
K
L
A
D
F
G
M
C
K
E
----
G
I
----------------
C
G
T
P
D
Y
I
A
P
E
I
L
Q
E
M
-----
L
-
Y
G
P
A
V
D
W
W
A
M
G
V
L
L
Y
E
M
L
C
G
H
-
A
P
F
E
A
E
N
E
D
---
D
L
F
E
A
---------
I
-
L
N
--
D
E
V
----
V
Y
--
P
-----
T
W
---
L
H
E
D
A
T
G
I
L
K
S
F
M
T
K
N
P
T
M
--
R
L
-
G
-
S
--
L
--
T
-
Q
G
G
-
E
HA
I
L
R
H
P
F
F
K
E
I
D
---
W
A
Q
L
N
H
R
Q
I
E
P
P
F
R
P
R
I
K
S
R
E
D
V
S
N
F
D
P
D
F
I
K
E
E
-
P
V
L
P
I
D
E
G
H
L
P
M
I
N
------
Q
D
E
F
R
N
F
E
Y
---
V
S
P
------
114
Blastp_CBE
72.13
44%
-79
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[3-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
K
K
---
T
---
N
----
Q
F
F
A
I
K
A
L
K
K
D
-
V
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
N
M
L
G
D
-
A
K
--
T
N
----
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
-
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
G
Q
D
E
E
---
E
L
F
H
S
---------
I
R
M
D
--
N
P
F
----
Y
P
--
R
------
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
-------------------------------------------
116
Blastp_CBE
71.78
44%
-76
- C1 -
-
4Q9Z
1
KPCT_HUMAN
A:
[3-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
K
K
---
T
---
N
----
Q
F
F
A
I
K
A
L
K
K
D
-
V
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
N
M
L
G
D
-
A
K
--
T
N
----
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
-
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
G
Q
D
E
E
---
E
L
F
H
S
---------
I
R
M
D
--
N
P
F
----
Y
P
--
R
------
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
-------------------------------------------
30
Blastp_CBE
71.68
51%
-48
- C1 -
-
6S9W
1
?
A:
[149-444]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
---
A
T
--
M
K
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
--------------------------------------------
113
Blastp_CBE
71.49
44%
-76
- C1 -
-
4RA5
1
B:
[3-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
K
K
---
T
---
N
----
Q
F
F
A
I
K
A
L
K
K
D
-
V
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
N
M
L
G
D
-
A
K
--
T
N
----
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
-
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
G
Q
D
E
E
---
E
L
F
H
S
---------
I
R
M
D
--
N
P
F
----
Y
P
--
R
------
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
-------------------------------------------
58
Blastp_CBE
71.06
45%
-16
- C1 -
-
4L46
1
KS6B1_HUMAN
A:
[9-345]
---------------------------------------------------------------------------------------------------------------------------------------------------
N
R
G
P
E
---
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
D
-------
H
----
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
---
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
-
P
V
-------------------
Q
V
F
L
G
F
Y
V
---
A
P
-------
571
Fugue
70.95
42%
-50
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[20-452]
-----------------
I
V
K
E
G
W
L
H
K
R
G
E
Y
I
T
W
R
P
R
Y
F
L
L
K
N
D
G
T
F
I
G
Y
K
-
E
R
P
A
P
L
N
N
F
S
V
A
Q
C
Q
L
M
K
T
E
R
P
---------
R
P
N
T
F
I
I
R
C
L
Q
W
T
T
V
I
E
R
T
F
H
V
E
-----------------------
T
P
E
E
R
E
E
W
T
T
A
I
Q
R
V
T
M
N
E
---------------
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
V
----------------------
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
---------------------------
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
G-
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
--------------------------------------------------
55
Blastp_CBE
70.81
45%
-2
- C1 -
-
4L43
1
KS6B1_HUMAN
A:
[10-346]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
---
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
D
S
K
F
T
R
Q
T
-
P
V
-------------
S
---
A
N
Q
V
F
L
G
F
A
Y
---
V
A
P
S
-----
162
Blastp_CBE
70.75
41%
-84
- C1 -
-
2UZW
1
KAPCA_BOVIN
E:
[29-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-------
V
K
-
G
R
--
T
W
----
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
109
Blastp_CBE
70.63
44%
-80
- C1 -
-
5F9E
1
B:
[16-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
K
K
---
T
---
N
----
Q
F
F
A
I
K
A
L
K
K
D
-
V
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
N
M
L
G
D
-
A
K
--
T
N
----
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
-
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
G
Q
D
E
E
---
E
L
F
H
S
---------
I
R
M
D
--
N
P
F
----
Y
P
--
R
------
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
--
S
N
F
D
--
F
L
N
E
-------------------------------------------
31
Blastp_CBE
70.49
51%
-46
- C1 -
-
6HHJ
1
AKT1_HUMAN
A:
[149-444]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
D
G
-
A
T
--
M
K
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
--------------------------------------------
165
Blastp_CBE
70.40
41%
-85
- C1 -
-
2UZT
1
KAPCA_BOVIN
A:
[29-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-------
V
K
-
G
R
--
T
W
----
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
557
HHSearch
70.11
45%
-61
- C1 -
-
5LI1
2
KPCI_HUMAN
A:
[8-347]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
L
Q
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
T
--
T
S
----
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
D
I
----TED
Y
L
F
Q
V
---------
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
--
H
PQ
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
Q
L
T
P
D
D
D
D
I
V
------
R
K
I
D
Q
S
E
F
E
G
F
E
Y
---
I
N
P
L
L
----
170
Blastp_CBE
69.98
41%
-80
- C1 -
-
2F7E
1
KAPCA_BOVIN
E:
[44-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-------
V
K
-
G
R
--
T
W
----
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
168
Blastp_CBE
69.88
41%
-89
- C1 -
-
2F7Z
1
KAPCA_BOVIN
E:
[44-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-------
V
K
-
G
R
--
T
W
----
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
167
Blastp_CBE
69.88
41%
-86
- C1 -
-
2OH0
1
KAPCA_BOVIN
E:
[44-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-------
V
K
-
G
R
--
T
W
----
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
166
Blastp_CBE
69.83
41%
-83
- C1 -
-
2OJF
1
KAPCA_BOVIN
E:
[44-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-------
V
K
-
G
R
--
T
W
----
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
115
Blastp_CBE
69.72
44%
-73
- C1 -
-
4Q9Z
1
B:
[3-320]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
I
E
D
F
E
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
K
K
---
T
---
N
----
Q
F
F
A
I
K
A
L
K
K
D
-
V
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
N
M
L
G
D
-
A
K
--
T
N
----
E
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
-
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
G
Q
D
E
E
---
E
L
F
H
S
---------
I
R
M
D
--
N
P
F
----
Y
P
--
R
------
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
F
R
P
K
V
K
S
P
F
D
C
S
N
F
D
K
E
F
L
N
E
-------------------------------------------
163
Blastp_CBE
69.50
41%
-84
- C1 -
-
2UZV
1
KAPCA_BOVIN
A:
[29-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-------
V
K
-
G
R
--
T
W
----
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
169
Blastp_CBE
69.27
41%
-79
- C1 -
-
2F7X
1
KAPCA_BOVIN
E:
[44-340]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-------
V
K
-
G
R
--
T
W
----
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
54
Blastp_CBE
69.14
45%
5
- C1 -
-
4L44
1
KS6B1_HUMAN
A:
[10-346]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
G
P
E
---
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
--------
H
----
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
-
D
S
K
F
T
R
Q
T
--------------
S
E
S
---
A
N
Q
V
F
L
G
F
A
Y
---
V
A
P
S
-----
164
Blastp_CBE
68.11
41%
-86
- C1 -
-
2UZU
1
KAPCA_BOVIN
E:
[29-325]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
-------
V
K
-
G
R
--
T
W
----
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
566
HHSearch
67.57
42%
-43
- C1 -
-
4OTH
1
A:
[9-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
-
L
E
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
R
P
---
S
---
G
----
E
L
F
A
I
K
A
L
K
K
G
-
D
I
V
-
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
AA
V
T
-
S
A
-
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
--
D
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
-
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
-
G
Y
V
K
I
A
D
F
G
L
C
K
----------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
P
G
D
D
E
E
---
E
V
F
D
S
---------
I
-
V
N
--
D
E
V
----
R
Y
--
P
-----
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
-
G
-
S
--
S
--
E
R
D
A
E
-
D
--
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
E
E
F
T
G
E
A
P
T
L
S
P
P
R
D
A
-----
R
P
L
T
A
A
E
Q
A
A
F
L
D
F
D
F
---
V
A
-------
568
HHSearch
67.29
44%
-52
- C1 -
-
4RA4
1
KPCA_HUMAN
A:
[17-347]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
-
L
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
A
D
---
R
K
G
---
T
---
E
----
E
L
Y
A
I
K
I
L
K
K
D
-
V
V
I
-
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
---
A
-
L
L
D
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
H
M
M
D
G
-
V
T
--
T
R
----
T
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
-----
P
-
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
-
P
P
F
D
G
E
D
E
D
---
E
L
F
Q
S
---------
I
-
M
E
--
H
N
V
----
S
Y
--
P
-----
K
S
---
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
--
R
L
-
G
-
C
--
G
P-
E
-
G
E
R
-
D
--
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
----------------
G
Q
P
V
L
T
P
P
D
Q
L
------
V
I
A
N
I
D
Q
S
D
F
E
G
F
S
Y
---
V
N
P
Q
F
V
---
564
HHSearch
67.12
47%
2
- C1 -
-
4L44
1
KS6B1_HUMAN
A:
[15-346]
------------------------------------------------------------------------------------------------------------------------------------------------------------
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
GAN
T
---
G
----
K
I
F
A
M
K
V
L
K
K
A
-
M
I
V
R
N
A
K
D
T
A
H
T
K
A
E
R
N
I
---
L
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
--------
H
----
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
--
P
G
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
-
D
S
K
F
T
R
Q
T
-----------------
S
E
S
A
N
Q
V
F
L
G
F
A
Y
---
V
A
P
S
-----
32
Blastp_CBE
67.06
51%
-39
- C1 -
-
6HHI
1
AKT1_HUMAN
A:
[149-444]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
--------------------
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
----
T
--
M
K
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
--------------------------------------------
84
Blastp_CBE
66.62
47%
-12
- C1 -
-
3WE4
1
KS6B1_HUMAN
A:
[15-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
-
D
-----
V
T
----
H
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
----------------------------------------------------------
78
Blastp_CBE
66.46
47%
-5
- C1 -
-
4L42
1
KS6B1_HUMAN
A:
[13-346]
-------------------------------------------------------------------------------------------------------------------------------------------------------
E
---
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
D
G
-
T
V
--
T
H
----
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
E
E
D
V
S
Q
F
--------------------------------------------------
56
Blastp_CBE
66.40
46%
-64
- C1 -
-
4DC2
1
KPCI_MOUSE
A:
[53-361]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
R
V
V
K
K
E
-
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
T
--
T
S
----
T
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
V
---
G
S
---NTEDYLFQV
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-----------------------------------------
500
Blastp_CBE
66.33
38%
-105
- C1 -
-
3QD3
3
PDPK1_HUMAN
A:
[34-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
268
Blastp_CBE
66.17
44%
-29
- C1 -
-
4OTG
1
A:
[13-339]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
R
P
---
S
---
G
----
E
L
F
A
I
K
A
L
K
K
G
-
D
I
V
-
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
AA
V
T
-
S
A
-
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
-
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
-
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
-
G
Y
V
K
I
A
D
F
G
L
C
K
E
----
G
M
G
Y
G
-
D
R
--
T
S
----
T
F
C
G
T
P
E
F
L
A
P
E
V
L
T
D
T
-----
S
-
Y
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
P
G
D
D
E
E
---
E
V
F
D
S
---------
I
-
V
N
--
D
E
V
----
R
Y
--
P
-----
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
-
G
-
S
--
S
--
E
R
D
A
E
-
D
--
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
E
E
F
T
G
E
A
------------------------------------------
81
Blastp_CBE
66.15
47%
-9
- C1 -
-
3WF7
2
KS6B1_HUMAN
A:
[13-304]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
---
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
-
D
-----
V
T
----
H
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
----------------------------------------------------------
457
Blastp_CBE
65.96
38%
-102
- C1 -
-
2PE2
9
PDPK1_HUMAN
A:
[5-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
34
Blastp_CBE
65.94
51%
-36
- C1 -
-
6HHG
1
AKT1_HUMAN
A:
[149-444]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
-----------------------
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
----
T
--
M
K
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
--------------------------------------------
469
Blastp_CBE
65.74
37%
-53
- C1 -
-
4UAK
2
MRCKB_HUMAN
A:
[77-389]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
M
K
N
---
T
---
E
----
R
I
Y
A
M
K
I
L
N
K
W
-
E
M
L
-
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
--
V
--
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
-
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
-------
L
K
M
N
-
D
D
--
G
T
VQSS
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
EDGMG
K
-
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
Y
A
E
S
L
V
---
E
T
Y
G
K
---------
I
-
M
N
--
H
E
E
----
R
F
--
Q
FPSHV
T
D
---
V
S
E
E
A
K
D
L
I
Q
R
L
I
-
C
S
R
E
R
--
R
L
-
G
-
Q
--
N
GI
E
-
D
F
------
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
------------------------------------------------
459
Blastp_CBE
65.73
38%
-103
- C1 -
-
2PE0
4
PDPK1_HUMAN
A:
[5-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
470
Blastp_CBE
65.66
37%
-52
- C1 -
-
3TKU
3
MRCKB_HUMAN
B:
[91-407]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
M
K
N
---
T
---
E
----
R
I
Y
A
M
K
I
L
N
K
W
-
E
M
L
-
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
--
V
--
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
-
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
-------
L
K
M
N
-
D
D
--
G
T
VQSS
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
EDGMG
K
-
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
Y
A
E
S
L
V
---
E
T
Y
G
K
---------
I
-
M
N
--
H
E
E
----
R
F
--
Q
FPSHV
T
D
---
V
S
E
E
A
K
D
L
I
Q
R
L
I
-
C
S
R
E
R
--
R
L
-
G
-
Q
--
N
GI
E
-
D
F
------
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
------------------------------------------------
460
Blastp_CBE
65.61
38%
-102
- C1 -
-
1Z5M
4
PDPK1_HUMAN
A:
[5-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
517
Blastp_CBE
65.59
38%
-102
- C1 -
-
3NUN
5
PDPK1_HUMAN
A:
[15-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
458
Blastp_CBE
65.57
38%
-103
- C1 -
-
2PE1
5
PDPK1_HUMAN
A:
[5-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
496
Blastp_CBE
65.56
38%
-109
- C1 -
-
1UU3
9
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
87
Blastp_CBE
65.54
48%
-12
- C1 -
-
4L3L
1
KS6B1_HUMAN
A:
[14-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
D
G
-
T
V
--
T
H
----
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------
506
Blastp_CBE
65.46
38%
-106
- C1 -
-
3IOP
1
PDPK1_HUMAN
A:
[34-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
468
Blastp_CBE
65.50
37%
-53
- C1 -
-
4UAL
2
MRCKB_HUMAN
A:
[77-385]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
M
K
N
---
T
---
E
----
R
I
Y
A
M
K
I
L
N
K
W
-
E
M
L
-
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
--
V
--
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
-
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
-------
L
K
M
N
-
D
D
--
G
T
V---
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
EDG--
K
-
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
Y
A
E
S
L
V
---
E
T
Y
G
K
---------
I
-
M
N
--
H
E
E
----
R
F
--
Q
FPSHV
T
D
---
V
S
E
E
A
K
D
L
I
Q
R
L
I
-
C
S
R
E
R
--
R
L
-
G
-
Q
--
N
GI
E
-
D
F
------
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
------------------------------------------------
29
Blastp_CBE
65.46
51%
-43
- C1 -
-
6S9X
1
?
A:
[149-443]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
--------------------
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
--------------
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
---------------------------------------------
88
Blastp_CBE
65.40
48%
-11
- C1 -
-
4L3J
1
KS6B1_HUMAN
A:
[14-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
D
G
-
T
V
--
T
H
----
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------
498
Blastp_CBE
65.19
38%
-100
- C1 -
-
1OKY
4
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
-----------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
454
Blastp_CBE
65.12
38%
-101
- C1 -
-
1UU9
8
PDPK1_HUMAN
A:
[7-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
476
Blastp_CBE
65.08
38%
-107
- C1 -
-
5LVP
1
PDPK1_HUMAN
C:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
462
Blastp_CBE
65.02
38%
-101
- C1 -
-
3NUU
5
PDPK1_HUMAN
A:
[6-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
504
Blastp_CBE
64.94
38%
-106
- C1 -
-
3QCS
5
PDPK1_HUMAN
A:
[34-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
467
Blastp_CBE
64.81
37%
-48
- C1 -
-
5OTE
2
MRCKB_HUMAN
A:
[77-384]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
M
K
N
---
T
---
E
----
R
I
Y
A
M
K
I
L
N
K
W
-
E
M
L
-
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
--
V
--
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
-
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
-------
L
K
M
N
-
D
D
--
G
T
VQSS
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
EDG--
K
-
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
Y
A
E
S
L
V
---
E
T
Y
G
K
---------
I
-
M
N
--
H
E
E
----
R
F
--
Q
FPSHV
T
D
---
V
S
E
E
A
K
D
L
I
Q
R
L
I
-
C
S
R
E
R
--
R
L
-
G
-
Q
--
N
GI
E
-
D
F
------
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
------------------------------------------------
509
Blastp_CBE
64.62
38%
-104
- C1 -
-
3RWP
5
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
36
Blastp_CBE
64.61
51%
-46
- C1 -
-
4EJN
3
AKT1_HUMAN
A:
[149-438]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
---------------
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
--------
K
----
T
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
--------------------------------------------------
534
Blastp_CBE
64.59
38%
-103
- C1 -
-
3NAY
1
PDPK1_HUMAN
A:
[30-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
535
Blastp_CBE
64.58
37%
-103
- C1 -
-
2XCK
5
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
T
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
503
Blastp_CBE
64.56
38%
-108
- C1 -
-
3QCX
6
PDPK1_HUMAN
A:
[34-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
493
Blastp_CBE
64.42
38%
-110
- C1 -
-
2R7B
2
PDPK1_HUMAN
A:
[34-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
----------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
461
Blastp_CBE
64.36
38%
-101
- C1 -
-
3NUY
5
PDPK1_HUMAN
A:
[6-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
516
Blastp_CBE
64.35
38%
-101
- C1 -
-
2XCH
7
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
497
Blastp_CBE
64.31
38%
-108
- C1 -
-
1OKZ
7
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
507
Blastp_CBE
64.11
38%
-102
- C1 -
-
3H9O
1
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
502
Blastp_CBE
64.03
38%
-104
- C1 -
-
3QCY
5
PDPK1_HUMAN
A:
[34-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
----------------
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
501
Blastp_CBE
63.87
38%
-102
- C1 -
-
3QD0
6
PDPK1_HUMAN
A:
[34-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
-----------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
463
Blastp_CBE
63.83
38%
-102
- C1 -
-
3NUS
5
PDPK1_HUMAN
A:
[6-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
499
Blastp_CBE
63.59
38%
-102
- C1 -
-
3QD4
1
PDPK1_HUMAN
A:
[34-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
-----------------
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
505
Blastp_CBE
63.57
38%
-105
- C1 -
-
3QCQ
5
PDPK1_HUMAN
A:
[34-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
106
Blastp_CBE
63.53
46%
3
- C1 -
-
4NW5
1
KS6A3_HUMAN
A:
[23-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
---
G
SDAR
Q
L
Y
A
M
K
V
L
-
K
K
-
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----
S
I
D
H
E
-
K
K
--
A
Y
----
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
--
P
-
D
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
-------------------------------------------------
495
Blastp_CBE
63.52
38%
-91
- C1 -
-
1UU7
4
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K----------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
267
Blastp_CBE
63.45
44%
-42
- C1 -
-
4OTH
1
A:
[13-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
R
P
---
S
---
G
----
E
L
F
A
I
K
A
L
K
K
G
-
D
I
V
-
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
AA
V
T
-
S
A
-
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
-
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
-
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
-
G
Y
V
K
I
A
D
F
G
L
C
K
----------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
P
G
D
D
E
E
---
E
V
F
D
S
---------
I
-
V
N
--
D
E
V
----
R
Y
--
P
-----
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
-
G
-
S
--
S
--
E
R
D
A
E
-
D
--
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
E
E
F
T
G
E
A
------------------------------------------
492
Blastp_CBE
63.43
38%
-107
- C1 -
-
3ION
1
PDPK1_HUMAN
A:
[34-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
----------------
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
565
HHSearch
63.34
33%
-66
- C1 -
-
6ED6
1
ROCK2_HUMAN
A:
[85-413]
------------------------------------------------------------------------------------------------------------------------------------------------------------
M
K
-
A
E
D
Y
D
V
V
K
V
I
G
R
G
-
A
F
G
E
V
Q
L
V
R
---
H
K
A
---
S
---
Q
----
K
V
Y
A
M
K
L
L
S
K
F
-
E
M
I
-
K
R
S
D
S
A
F
F
W
E
E
R
D
-
I
--
M
A
-
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
-
Y
L
Y
M
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
-
Y
-
D
V
P
E
K
W
A
K
F
Y
T
A
E
V
V
L
A
L
D
A
I
H
S
-
M
G
-
L
I
H
R
D
V
K
P
D
N
M
L
L
D
K
H
-
G
H
L
K
L
A
D
F
G
T
C
M
K
----
M
D
E
T
G
M
V
H
--
C
D
----
T
A
V
G
T
P
D
Y
I
S
P
E
V
L
K
S
Q
------F
Y
G
R
E
C
D
W
W
S
V
G
V
F
L
Y
E
M
L
V
G
D
-
T
P
F
Y
A
D
S
L
V
---
G
T
Y
S
K
---------
I
-
M
D
--
H
K
N
SLCF
P
E
--
D
-----
A
E
---
I
S
K
H
A
K
N
L
I
C
A
F
L
T
D
R
E
V
R
LG
R
N
-
G
-
V
--
E
--------
E
--
I
R
Q
H
P
F
F
K
N
D
Q
---
W
H
W
D
N
I
R
E
T
A
A
P
V
V
P
E
L
S
S
D
I
D
S
S
N
F
D
D
I
-------
E
T
F
P
I
-------
P
K
A
F
V
G
N
Q
L
P
F
I
G
F
T
Y
------------
464
Blastp_CBE
63.33
37%
-50
- C1 -
-
3QFV
3
MRCKB_HUMAN
B:
[75-390]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
I
K
V
I
G
R
G
-
A
F
G
E
V
A
V
V
K
---
M
K
N
---
T
---
E
----
R
I
Y
A
M
K
I
L
N
K
W
-
E
M
L
-
K
R
A
E
T
A
C
F
R
E
E
R
D
V
L
--
V
--
N
G
-
D
C
Q
W
I
T
A
L
H
Y
A
F
Q
D
E
N
-
H
L
Y
L
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
F
E
D
K
L
P
E
D
M
A
R
F
Y
I
G
E
M
V
L
A
I
D
S
I
H
Q
-
L
H
-
Y
V
H
R
D
I
K
P
D
N
V
L
L
D
V
N
-
G
H
I
R
L
A
D
F
G
S
C
-------
L
K
M
N
-
D
D
--
G
T
VQSS
V
A
V
G
T
P
D
Y
I
S
P
E
I
L
Q
A
M
EDGMG
K
-
Y
G
P
E
C
D
W
W
S
L
G
V
C
M
Y
E
M
L
Y
G
E
-
T
P
F
Y
A
E
S
L
V
---
E
T
Y
G
K
---------
I
-
M
N
--
H
E
E
----
R
F
--
Q
FPSHV
T
D
---
V
S
E
E
A
K
D
L
I
Q
R
L
I
-
C
S
R
E
R
--
R
L
-
G
-
Q
--
N
GI
E
-
D
F
------
K
K
H
A
F
F
E
G
L
N
---
W
E
N
I
--
R
N
L
E
A
P
Y
I
P
D
V
S
S
P
S
D
T
S
N
F
D
V
------------------------------------------------
35
Blastp_CBE
63.09
51%
-48
- C1 -
-
6HHF
1
AKT1_HUMAN
A:
[149-439]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
-----------------------
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
-------------------------
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-------------------------------------------------
510
Blastp_CBE
63.03
38%
-102
- C1 -
-
3SC1
3
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
53
Blastp_CBE
63.07
47%
-28
- C1 -
-
6CCY
1
AKT1_HUMAN
A:
[1-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
L
R
V
T
-
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
S
R
V
L
---
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
-
G
-
G
--
G
P-
S
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
V
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
T
I
T
P
----------------
Q
E
M
F
R
D
F
D
Y
------------
178
Blastp_CBE
63.03
42%
-65
- C1 -
-
5MHI
4
KAPCA_CRIGR
A:
[34-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
174
Blastp_CBE
62.92
42%
-71
- C1 -
-
5N32
3
KAPCA_CRIGR
A:
[34-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
-
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
533
Blastp_CBE
62.84
38%
-108
- C1 -
-
3NAY
1
PDPK1_HUMAN
B:
[30-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
536
Blastp_CBE
62.72
37%
-105
- C1 -
-
3PWY
1
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
C
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
-------------
S
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
S
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
107
Blastp_CBE
62.51
46%
-3
- C1 -
-
4NUS
1
KS6A3_HUMAN
A:
[23-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
---
G
SDAR
Q
L
Y
A
M
K
V
L
-
K
K
-
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----
S
I
D
H
E
-
K
K
--
A
Y
----
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
--
P
-
D
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
------
T
F
Y
F
D
-------------------------------------------------
105
Blastp_CBE
62.46
46%
2
- C1 -
-
4NW6
1
KS6A3_HUMAN
A:
[23-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
---
G
SDAR
Q
L
Y
A
M
K
V
L
-
K
K
-
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----
S
I
D
H
E
-
K
K
--
A
Y
----
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
--
P
-
D
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
-------------------------------------------------
176
Blastp_CBE
62.45
42%
-65
- C1 -
-
5N1E
4
KAPCA_CRIGR
A:
[33-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
494
Blastp_CBE
62.34
38%
-107
- C1 -
-
1UU8
7
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
578
Fugue
62.32
38%
-2
- C1 -
-
1CDK
2
KAPCA_PIG
A:
[8-350]
-----------------------------------------------------------------------------------------------------------------------
K
G
S
E
Q
E
S
V
K
E
F
L
A
K
A
K
E
D
F
L
K
K
W
E
N
P
A
Q
N
T
A
------
H
--
L
D
Q
F
E
R
I
K
T
L
G
T
-G
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
G-------
N
H
F
A
M
K
I
L
D
K
Q
-
K
V
V
K-
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
--
Q
A
V---
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
-S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
I-
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
-Q
G
Y
I
Q
V
T
D
F
G
F
A
K
R
----
V
-
K
---
G
----
R
TW--
T
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
-KGY-----
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
-Y
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
PS-------
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
L-
K
--
D
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
---TTD
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
I
R
V
S
I
---------
N
E
K
C
G
----
K
E
F
S
E
F
--------------
179
Blastp_CBE
62.21
42%
-66
- C1 -
-
5M75
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
159
Blastp_CBE
62.21
42%
-74
- C1 -
-
4NTT
1
KAPCA_MOUSE
B:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
153
Blastp_CBE
62.13
42%
-65
- C1 -
-
1FMO
1
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
173
Blastp_CBE
62.01
42%
-67
- C1 -
-
5N7P
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
187
Blastp_CBE
61.99
42%
-66
- C1 -
-
5LCU
5
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
146
Blastp_CBE
61.93
42%
-63
- C1 -
-
3IDC
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
149
Blastp_CBE
61.82
42%
-69
- C1 -
-
1REK
2
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
172
Blastp_CBE
61.72
42%
-66
- C1 -
-
5N7U
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
190
Blastp_CBE
61.68
42%
-63
- C1 -
-
5LCQ
3
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
33
Blastp_CBE
61.42
51%
-40
- C1 -
-
6HHH
1
AKT1_HUMAN
A:
[149-439]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
----------------
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
------------------
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
-------------------------------------------------
177
Blastp_CBE
61.40
42%
-65
- C1 -
-
5N1D
3
KAPCA_CRIGR
A:
[34-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
175
Blastp_CBE
61.33
42%
-63
- C1 -
-
5N1K
4
KAPCA_CRIGR
A:
[34-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
----
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
156
Blastp_CBE
61.24
42%
-66
- C1 -
-
1BX6
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
186
Blastp_CBE
61.21
42%
-64
- C1 -
-
5M0B
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
104
Blastp_CBE
61.17
46%
5
- C1 -
-
5D9L
2
KS6A3_HUMAN
A:
[23-322]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
---
G
SDAR
Q
L
Y
A
M
K
V
L
-
K
K
-
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
-----------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
--
P
-
D
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
T
G
R
P
E
D
T
F
Y
F
D
-------------------------------------------------
144
Blastp_CBE
61.14
42%
-65
- C1 -
-
3OW3
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
266
Blastp_CBE
61.12
44%
-42
- C1 -
-
4OTI
1
A:
[13-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
L
A
V
L
G
R
G
-
H
F
G
K
V
L
L
S
E
---
F
R
P
---
S
---
G
----
E
L
F
A
I
K
A
L
K
K
G
-
D
I
V
-
A
R
D
E
V
E
S
L
M
C
E
K
R
I
L
AA
V
T
-
S
A
-
G
H
P
F
L
V
N
L
F
G
C
F
Q
T
P
E
-
H
V
C
F
V
M
E
Y
S
A
G
G
D
L
M
L
H
I
H
S
-
D
-
V
F
S
E
P
R
A
I
F
Y
S
A
C
V
V
L
G
L
Q
F
L
H
E
-
H
K
-
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
-
G
Y
V
K
I
A
D
F
G
L
------------------------------------------------
T
R
A
V
D
W
W
G
L
G
V
L
L
Y
E
M
L
V
G
E
-
S
P
F
P
G
D
D
E
E
---
E
V
F
D
S
---------
I
-
V
N
--
D
E
V
----
R
Y
--
P
-----
R
F
---
L
S
A
E
A
I
G
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
-
G
-
S
--
S
--
E
R
D
A
E
-
D
--
V
K
K
Q
P
F
F
R
T
L
G
---
W
E
A
L
L
A
R
R
L
P
P
P
F
V
P
T
L
S
G
R
T
D
V
S
N
F
D
E
E
F
T
G
E
A
------------------------------------------
69
Blastp_CBE
61.11
46%
-76
- C1 -
-
3A8W
1
KPCI_HUMAN
B:
[10-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
---
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
---------EDYLFQV--
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-----------------------------------------
180
Blastp_CBE
61.09
42%
-64
- C1 -
-
5M71
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
155
Blastp_CBE
61.07
42%
-64
- C1 -
-
2GU8
1
KAPCA_HUMAN
A:
[20-321]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
E
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
137
Blastp_CBE
61.06
42%
-67
- C1 -
-
6MM6
1
KAPCA_MOUSE
E:
[22-336]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
182
Blastp_CBE
61.05
42%
-63
- C1 -
-
5M6V
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
25
Blastp_CBE
60.91
50%
-24
- C1 -
-
3MVH
1
AKT1_HUMAN
A:
[7-329]
------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
-
M
N
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
185
Blastp_CBE
60.90
42%
-65
- C1 -
-
5M0C
3
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
143
Blastp_CBE
60.80
42%
-65
- C1 -
-
4DIN
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
160
Blastp_CBE
60.78
42%
-75
- C1 -
-
4NTT
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
518
Blastp_CBE
60.75
38%
-55
- C1 -
-
2BIY
8
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
-
K
Q
AR
A
N
----
A
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
191
Blastp_CBE
60.73
42%
-62
- C1 -
-
5LCP
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
184
Blastp_CBE
60.70
42%
-60
- C1 -
-
5M0L
3
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
98
Blastp_CBE
60.70
46%
-11
- C1 -
-
5D9K
2
KS6A3_HUMAN
A:
[26-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
---
G
SDAR
Q
L
Y
A
M
K
V
L
-
K
K
-
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
-----------------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
--
P
-
D
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
A
------
T
F
Y
F
D
P
------------------------------------------------
422
Blastp_CBE
60.69
41%
-76
- C1 -
-
3AMA
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
Q
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
N
F
D
D
Y
E
E
E
E
-------------------------------------------
120
Blastp_CBE
60.67
46%
-89
- C1 -
-
3PFQ
1
KPCB_RAT
A:
[293-635]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
L
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
S
E
---
R
K
G
---
T
---
D
----
E
L
Y
A
V
K
I
L
K
K
D
-
V
V
I
-
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
--
A
L
-
P
G
-
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
R
F
K
E
P
H
A
V
F
Y
A
A
E
I
A
I
G
L
F
F
L
Q
S
-
K
G
-
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
N
I
-
W
D
-
G
V
--
T
T
----
K
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
-----
P
-
Y
G
K
S
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
-
A
P
F
E
G
E
D
E
D
---
E
L
F
Q
S
---------
I
-
M
E
--
H
N
V
----
A
Y
--
P
-----
K
S
---
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
G
K
--
R
L
-
G
-
C
--
G
P-
E
-
G
E
R
-
D
--
I
K
E
H
A
F
F
R
Y
I
D
---
W
E
K
L
E
R
K
E
I
Q
P
P
Y
K
P
K
A
S
G
-
R
N
A
E
N
F
D
R
F
F
T
---------------------------------------------
345
Blastp_CBE
60.57
42%
-70
- C1 -
-
1SMH
6
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
E
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
L
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
142
Blastp_CBE
60.56
42%
-65
- C1 -
-
4HPT
1
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
378
Blastp_CBE
60.52
42%
-68
- C1 -
-
1SVE
2
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
189
Blastp_CBE
60.42
42%
-62
- C1 -
-
5LCR
6
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
140
Blastp_CBE
60.41
42%
-59
- C1 -
-
2ERZ
1
KAPCA_MOUSE
E:
[34-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
188
Blastp_CBE
60.39
42%
-62
- C1 -
-
5LCT
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
181
Blastp_CBE
60.35
42%
-61
- C1 -
-
5M6Y
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
147
Blastp_CBE
60.33
42%
-62
- C1 -
-
3IDB
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
134
Blastp_CBE
60.29
42%
-62
- C1 -
-
6MM8
6
KAPCA_MOUSE
C:
[22-339]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
210
Blastp_CBE
60.28
42%
-65
- C1 -
-
1RDQ
3
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
A
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
148
Blastp_CBE
60.18
42%
-65
- C1 -
-
3FJQ
1
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
132
Blastp_CBE
60.18
42%
-66
- C1 -
-
1JBP
2
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
E
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
158
Blastp_CBE
60.17
41%
-64
- C1 -
-
3O7L
2
KAPCA_MOUSE
B:
[33-343]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
----
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
I
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
I
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
233
Blastp_CBE
60.10
42%
-62
- C1 -
-
3FHI
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
A
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
255
Blastp_CBE
60.07
42%
-67
- C1 -
-
3OOG
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
451
Blastp_CBE
60.06
39%
-95
- C1 -
-
5LOH
3
GWL_HUMAN
B:
[37-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
S
I
V
K
P
I
S
R
G
-
A
F
G
K
V
Y
L
G
Q
---
K
-----
G
---
G
----
K
L
Y
A
V
K
V
V
K
K
A
-
D
M
I
-
N
K
---------------
A
L
-
S
--
K
S
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
-
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
-
Y
G
Y
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
R
-
H
G
-
I
I
H
R
D
L
K
P
D
N
M
L
I
S
N
E
-
G
H
I
K
L
T
D
F
G
L
--------------------------
G
T
P
D
Y
L
A
P
E
L
L
L
G
R
-----
A
-
H
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
I
-
P
P
F
N
D
E
T
P
Q
---
Q
V
F
Q
N
---------
I
-
L
K
--
R
D
I
----
P
W
--
P
-----
E
G
EEK
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
--
R
A
-
G
-
M
--
K
--------
E
--
L
K
R
H
P
L
F
S
D
V
D
---
W
E
N
L
Q
H
Q
T
M
--
P
F
I
P
Q
---
P
--------------------------------------------------------
473
Blastp_CBE
60.03
38%
-98
- C1 -
-
3QC4
1
PDPK1_HUMAN
A:
[36-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
A
A
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
95
Blastp_CBE
59.98
46%
-76
- C1 -
-
4RA4
1
KPCA_HUMAN
A:
[15-347]
----------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
K
-
L
T
D
F
N
F
L
M
V
L
G
K
G
-
S
F
G
K
V
M
L
A
D
---
R
K
G
---
T
---
E
----
E
L
Y
A
I
K
I
L
K
K
D
-
V
V
I
-
Q
D
D
D
V
E
C
T
M
V
E
K
R
V
L
--
A
L
-
L
D
-
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
V
D
-
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
Q
Q
-
V
G
K
F
K
E
P
Q
A
V
F
Y
A
A
E
I
S
I
G
L
F
F
L
H
K
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
M
L
D
S
E
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
H
M
-
M
D
-
G
V
--
T
T
----
R
F
C
G
T
P
D
Y
I
A
P
E
I
I
A
Y
Q
-----
P
-
Y
G
K
S
V
D
W
W
A
Y
G
V
L
L
Y
E
M
L
A
G
Q
-
P
P
F
D
G
E
D
E
D
---
E
L
F
Q
S
---------
I
-
M
E
--
H
N
V
----
S
Y
--
P
-----
K
S
---
L
S
K
E
A
V
S
I
C
K
G
L
M
T
K
H
P
A
K
--
R
L
-
G
-
C
--
G
P-
E
-
G
E
R
-
D
--
V
R
E
H
A
F
F
R
R
I
D
---
W
E
K
L
E
N
R
E
I
Q
P
P
F
K
P
K
V
S
G
P
K
G
A
E
N
F
D
K
F
F
T
---------------------------------------------
70
Blastp_CBE
59.96
46%
-78
- C1 -
-
3A8W
1
KPCI_HUMAN
A:
[10-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-----
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
---------EDYLFQV--
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-----------------------------------------
410
Blastp_CBE
59.93
41%
-65
- C1 -
-
2GNI
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
380
Blastp_CBE
59.85
42%
-69
- C1 -
-
1Q8U
3
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
472
Blastp_CBE
59.84
38%
-103
- C1 -
-
3QC4
1
PDPK1_HUMAN
B:
[36-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
---------
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
A
A
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
139
Blastp_CBE
59.78
42%
-63
- C1 -
-
6MM5
1
KAPCA_MOUSE
E:
[22-323]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
360
Blastp_CBE
59.74
42%
-70
- C1 -
-
1SVH
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
344
Blastp_CBE
59.74
42%
-65
- C1 -
-
1XHA
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
E
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
L
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
183
Blastp_CBE
59.74
42%
-65
- C1 -
-
5M0U
10
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
-----
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
157
Blastp_CBE
59.67
42%
-68
- C1 -
-
1BKX
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
154
Blastp_CBE
59.67
42%
-63
- C1 -
-
1ATP
1
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
73
Blastp_CBE
59.65
46%
-75
- C1 -
-
5LI9
13
KPCI_HUMAN
A:
[7-315]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
----------EDYLFQV--
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-----------------------------------------
355
Blastp_CBE
59.64
42%
-73
- C1 -
-
4IJ9
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
135
Blastp_CBE
59.54
42%
-63
- C1 -
-
6MM7
9
KAPCA_MOUSE
D:
[22-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
37
Blastp_CBE
59.51
51%
-48
- C1 -
-
5KCV
1
AKT1_HUMAN
A:
[163-452]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
--------------------
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
---------------------------
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
--------------------------------------------------
381
Blastp_CBE
59.46
42%
-69
- C1 -
-
1Q8T
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
359
Blastp_CBE
59.46
42%
-69
- C1 -
-
1XH5
3
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
254
Blastp_CBE
59.45
42%
-67
- C1 -
-
3OVV
2
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
269
Blastp_CBE
59.41
42%
-66
- C1 -
-
6C0U
4
KAPCA_HUMAN
A:
[47-338]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
265
Blastp_CBE
59.35
42%
-66
- C1 -
-
3AGL
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
353
Blastp_CBE
59.21
42%
-72
- C1 -
-
2C1B
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
358
Blastp_CBE
59.22
42%
-68
- C1 -
-
1XH6
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
195
Blastp_CBE
59.21
41%
-70
- C1 -
-
1CDK
2
KAPCA_PIG
B:
[43-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
F
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
376
Blastp_CBE
59.20
42%
-67
- C1 -
-
1VEB
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
346
Blastp_CBE
59.19
42%
-70
- C1 -
-
1XH9
4
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
E
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
L
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
97
Blastp_CBE
59.14
46%
-6
- C1 -
-
5D9K
2
KS6A3_HUMAN
B:
[26-323]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
---
G
SDAR
Q
L
Y
A
M
K
V
L
-
K
K
-
A
T
L
-
K
V
R
D
R
V
R
T
K
M
E
R
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----------------------
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
--
P
-
D
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------
T
F
Y
F
D
P
------------------------------------------------
420
Blastp_CBE
59.12
41%
-65
- C1 -
-
2VO0
4
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
334
Blastp_CBE
59.10
42%
-68
- C1 -
-
3MVJ
1
KAPCA_HUMAN
E:
[64-355]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
263
Blastp_CBE
59.09
42%
-65
- C1 -
-
3VQH
2
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
350
Blastp_CBE
59.06
42%
-70
- C1 -
-
3ZO4
4
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
408
Blastp_CBE
59.04
41%
-68
- C1 -
-
2GNF
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
119
Blastp_CBE
58.99
47%
9
- C1 -
-
4EL9
1
KS6A3_MOUSE
A:
[18-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
---
G
SDAR
Q
L
Y
A
M
K
V
L
-
K
K
-
A
T
L
-
K
V
R
D
R
V
-----
R
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----
S
---
E
-
K
K
--
A
Y
----
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
--
P
-
D
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------
28
Blastp_CBE
58.98
52%
-53
- C1 -
-
3O96
1
AKT1_HUMAN
A:
[152-432]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
-----------
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
-------------------------
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
-----------------------------------------------------------
411
Blastp_CBE
58.96
41%
-69
- C1 -
-
2GNH
2
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
M
P
G
G
D
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
354
Blastp_CBE
58.90
42%
-73
- C1 -
-
2C1A
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
262
Blastp_CBE
58.88
42%
-67
- C1 -
-
4UJB
3
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
352
Blastp_CBE
58.90
42%
-72
- C1 -
-
2VO7
2
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
151
Blastp_CBE
58.88
42%
-63
- C1 -
-
1RE8
2
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
249
Blastp_CBE
58.87
42%
-70
- C1 -
-
4UJ1
2
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
65
Blastp_CBE
58.86
46%
-80
- C1 -
-
6ILZ
1
KPCI_HUMAN
C:
[11-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---------
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
---------DYLFQV---
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
--
E
P
V
-----------------------------------------
341
Blastp_CBE
58.83
41%
-69
- C1 -
-
3NX8
3
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
N
G
V
-
N
--
D
I
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
377
Blastp_CBE
58.81
42%
-70
- C1 -
-
1SVG
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
383
Blastp_CBE
58.75
42%
-74
- C1 -
-
2GNL
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
253
Blastp_CBE
58.76
42%
-67
- C1 -
-
3OWP
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
343
Blastp_CBE
58.75
42%
-69
- C1 -
-
3DND
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
257
Blastp_CBE
58.68
42%
-67
- C1 -
-
3L9L
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
347
Blastp_CBE
58.67
42%
-67
- C1 -
-
6E9L
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
349
Blastp_CBE
58.66
42%
-68
- C1 -
-
4IE9
2
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
260
Blastp_CBE
58.64
42%
-70
- C1 -
-
5BX7
4
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
415
Blastp_CBE
58.59
41%
-67
- C1 -
-
2UW7
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
197
Blastp_CBE
58.60
42%
-68
- C1 -
-
3QAL
1
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
A
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
193
Blastp_CBE
58.59
42%
-64
- C1 -
-
3QAM
1
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
A
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
452
Blastp_CBE
58.56
39%
-100
- C1 -
-
5LOH
2
GWL_HUMAN
A:
[37-316]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
S
I
V
K
P
I
S
-----
G
K
V
Y
L
G
Q
---
K
-----
G
---
G
----
K
L
Y
A
V
K
V
V
K
K
A
-
D
M
----------------
L
--
A
L
-
S
--
K
S
P
F
I
V
H
L
Y
Y
S
L
Q
S
A
N
-
N
V
Y
L
V
M
E
Y
L
I
G
G
D
V
K
S
L
L
H
I
-
Y
G
Y
F
D
E
E
M
A
V
K
Y
I
S
E
V
A
L
A
L
D
Y
L
H
R
-
H
G
-
I
I
H
R
D
L
K
P
D
N
M
L
I
S
N
E
-
G
H
I
K
L
T
D
F
G
L
S
K
----------------------
F
C
G
T
P
D
Y
L
A
P
E
L
L
L
G
R
-----
A
-
H
G
P
A
V
D
W
W
A
L
G
V
C
L
F
E
F
L
T
G
I
-
P
P
F
N
D
E
T
P
Q
---
Q
V
F
Q
N
---------
I
-
L
K
--
R
D
I
----
P
W
--
P
-----
E
G
EEK
L
S
D
N
A
Q
S
A
V
E
I
L
L
T
I
D
D
T
K
--
R
A
-
G
-
M
--
K
--------
E
--
L
K
R
H
P
L
F
S
D
V
D
---
W
E
N
L
Q
H
Q
T
M
--
P
F
I
P
Q
---
P
--------------------------------------------------------
418
Blastp_CBE
58.53
41%
-73
- C1 -
-
2JDV
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
171
Blastp_CBE
58.50
42%
-65
- C1 -
-
6F14
2
KAPCA_CRIGR
A:
[34-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
-----
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
519
Blastp_CBE
58.43
38%
-64
- C1 -
-
3NAX
1
PDPK1_HUMAN
A:
[30-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
-
K
Q
AR-----------
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
384
Blastp_CBE
58.46
42%
-68
- C1 -
-
2GNJ
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
I
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
251
Blastp_CBE
58.43
42%
-70
- C1 -
-
3P0M
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
108
Blastp_CBE
58.43
42%
-78
- C1 -
-
1XJD
1
A:
[16-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
D
F
I
L
H
K
M
L
G
K
G
-
S
F
G
K
V
F
L
A
E
---
F
K
K
---
T
---
N
----
Q
F
F
A
I
K
A
L
K
K
D
-
V
V
L
-
M
D
D
D
V
E
C
T
M
V
E
K
R
V
L
--
S
L
-
A
W
-
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
-
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
Q
S
-
C
H
K
F
D
L
S
R
A
T
F
Y
A
A
E
I
I
L
G
L
Q
F
L
H
S
-
K
G
-
I
V
Y
R
D
L
K
L
D
N
I
L
L
D
K
D
-
G
H
I
K
I
A
D
F
G
M
C
K
E
----
N
M
-
L
G
-
D
A
--
K
T
----
N
F
C
G
T
P
D
Y
I
A
P
E
I
L
L
G
Q
-----
K
-
Y
N
H
S
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
-
S
P
F
H
G
Q
D
E
E
---
E
L
F
H
S
---------
I
R
M
D
--
N
P
F
----
Y
P
--
R
------
W
---
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
E
K
--
R
L
-
G
-
V
--
R
--
G
-
D
------
I
R
Q
H
P
L
F
R
E
I
N
---
W
E
E
L
E
R
K
E
I
D
P
P
--------------------------------------------
N
M
F
R
N
F
F
M
---
N
--------
391
Blastp_CBE
58.41
41%
-68
- C1 -
-
1Q24
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
487
Blastp_CBE
58.35
38%
-102
- C1 -
-
4AW1
4
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
-----------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
357
Blastp_CBE
58.39
42%
-68
- C1 -
-
1XH8
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
50
Blastp_CBE
58.38
51%
-24
- C1 -
-
3OCB
1
AKT1_HUMAN
A:
[10-327]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
E
Y
L
K
L
L
G
K
G
-
T
F
G
K
V
I
L
V
K
---
E
K
A
---
T
---
G
----
R
Y
Y
A
M
K
I
L
K
K
E
-
V
I
V
-
A
K
D
E
V
A
H
T
L
T
E
-
N
R
V
--
L
Q
-
N
S
-
R
H
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
-
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
-
E
R
V
F
S
E
D
R
A
R
F
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
-
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
M
L
D
K
D
-
G
H
I
K
I
T
D
F
G
L
C
K
E
----
G
I
K
-
D
-
G
A
--
T
M
----
K
F
C
G
T
P
E
Y
L
A
P
E
V
L
E
D
N
-----
D
-
Y
G
R
A
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
-
L
P
F
Y
N
Q
D
H
E
---
K
L
F
E
L
---------
I
-
L
M
--
E
E
I
----
R
F
--
P
-----
R
T
---
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
K
Q
--
R
L
G
G
-
G
--
S
--
E
-
D
A
K
-
E
--
I
M
Q
H
R
F
F
A
G
I
V
---
W
Q
H
V
Y
E
K
K
L
S
P
P
F
K
P
Q
V
T
S
E
T
D
T
R
Y
F
D
E
E
F
T
A
Q
M
I
-----------------------------------------
348
Blastp_CBE
58.37
42%
-70
- C1 -
-
6E99
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
252
Blastp_CBE
58.35
42%
-69
- C1 -
-
3OXT
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
246
Blastp_CBE
58.33
42%
-69
- C1 -
-
4UJA
2
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
261
Blastp_CBE
58.32
42%
-66
- C1 -
-
5BX6
4
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
340
Blastp_CBE
58.27
42%
-66
- C1 -
-
4YXR
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
336
Blastp_CBE
58.24
42%
-63
- C1 -
-
3MVJ
1
KAPCA_HUMAN
A:
[64-355]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
150
Blastp_CBE
58.23
42%
-65
- C1 -
-
1REJ
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
122
Blastp_CBE
58.14
45%
-2
- C1 -
-
6G77
2
KS6A6_HUMAN
A:
[22-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
E
K
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
K
T
---
G
PDA
G
----
Q
L
Y
A
M
K
V
L
-
K
K
-
A
S
L
-
K
V
R
D
--------
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----
S
V
D
Q
E
-
K
K
--
A
Y
----
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
N
---
E
T
M
N
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
-
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------
342
Blastp_CBE
58.15
42%
-67
- C1 -
-
3DNE
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
270
Blastp_CBE
58.12
42%
-68
- C1 -
-
1YDT
1
KAPCA_BOVIN
E:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
117
Blastp_CBE
58.14
47%
5
- C1 -
-
3UBD
1
KS6A3_MOUSE
A:
[17-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
---
G
SDAR
Q
L
Y
A
M
K
V
L
-
K
K
-
A
T
L
-
K
V
R
D
R
V
------
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
---------
E
-
K
K
--
A
Y
----
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
--
P
-
D
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------
258
Blastp_CBE
58.13
42%
-65
- C1 -
-
3AGM
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
85
Blastp_CBE
58.11
47%
-16
- C1 -
-
3A62
1
KS6B1_HUMAN
A:
[13-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
---------------
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
---------------------
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
------------------------------------------------------------
64
Blastp_CBE
58.11
46%
-85
- C1 -
-
6ILZ
1
KPCI_HUMAN
E:
[12-318]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---------
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
---------DYLFQV---
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
--
P
V
-----------------------------------------
379
Blastp_CBE
58.09
42%
-70
- C1 -
-
1STC
1
KAPCA_BOVIN
E:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
414
Blastp_CBE
58.08
41%
-65
- C1 -
-
4AXA
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
392
Blastp_CBE
58.02
41%
-70
- C1 -
-
4Z84
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
272
Blastp_CBE
58.01
42%
-68
- C1 -
-
1YDR
1
KAPCA_BOVIN
E:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
66
Blastp_CBE
57.99
46%
-77
- C1 -
-
6ILZ
1
KPCI_HUMAN
A:
[11-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---------
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
V
--------DYLFQV---
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-----------------------------------------
333
Blastp_CBE
57.97
41%
-70
- C1 -
-
2QUR
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
P
-
N
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
A
D
D
Y
E
E
E
E
-------------------------------------------
382
Blastp_CBE
57.94
42%
-62
- C1 -
-
4WB6
1
KAPCA_HUMAN
B:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
264
Blastp_CBE
57.86
42%
-64
- C1 -
-
3AGL
1
KAPCA_HUMAN
B:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
271
Blastp_CBE
57.82
42%
-69
- C1 -
-
1YDS
1
KAPCA_BOVIN
E:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
339
Blastp_CBE
57.77
42%
-67
- C1 -
-
4YXS
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
241
Blastp_CBE
57.72
42%
-68
- C1 -
-
5UZK
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
363
Blastp_CBE
57.65
41%
-66
- C1 -
-
3L9M
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
121
Blastp_CBE
57.63
45%
4
- C1 -
-
6G77
2
KS6A6_HUMAN
B:
[22-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
E
K
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
K
T
---
G
PDA
G
----
Q
L
Y
A
M
K
V
L
-
K
K
-
A
S
L
-
K
V
R
D
--------
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----
S
V
D
Q
E
-
K
K
--
A
Y
----
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
N
---
E
T
M
N
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
-
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------
196
Blastp_CBE
57.61
41%
-70
- C1 -
-
1CDK
2
KAPCA_PIG
A:
[43-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
F
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
Y
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
-
N
--
L
--
K
-
D
G
V
N
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
419
Blastp_CBE
57.59
41%
-66
- C1 -
-
2JDT
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
361
Blastp_CBE
57.55
41%
-69
- C1 -
-
3L9N
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
---
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
248
Blastp_CBE
57.53
42%
-67
- C1 -
-
4UJ2
2
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
96
Blastp_CBE
57.51
46%
-4
- C1 -
-
3G51
1
KS6A3_MOUSE
A:
[17-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
---
G
SDAR
Q
L
Y
A
M
K
V
L
-
K
K
-
A
T
L
-
K
V
---------
R
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----
S
I
------------------
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
--
P
-
D
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------
63
Blastp_CBE
57.49
46%
-84
- C1 -
-
6ILZ
1
KPCI_HUMAN
G:
[11-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
---------
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
V
--------DYLFQV---
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
---
G
L
D
N
F
D
S
Q
F
T
--
P
V
-----------------------------------------
417
Blastp_CBE
57.43
41%
-67
- C1 -
-
2UVX
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
118
Blastp_CBE
57.40
47%
6
- C1 -
-
4GUE
1
KS6A3_MOUSE
A:
[18-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
E
K
A
D
-
P
S
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
K
----
K
I
---
S
---
G
SDAR
Q
L
Y
A
M
K
V
L
-
K
K
-
A
T
L
-
K
V
R
D
R
V
--------
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
---------
E
-
K
K
--
A
Y
----
S
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
T
Q
S
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
A
--
G
--
P
-
D
G
V
E
E
--
I
K
R
H
S
F
F
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
H
P
P
F
K
P
-------------------------------------------------------------
416
Blastp_CBE
57.37
41%
-62
- C1 -
-
2UW4
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
-
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
421
Blastp_CBE
57.32
41%
-72
- C1 -
-
3AMB
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
Q
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
-----
N
F
D
D
Y
E
E
E
E
-------------------------------------------
250
Blastp_CBE
57.31
42%
-69
- C1 -
-
3POO
2
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
----
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
256
Blastp_CBE
57.27
42%
-68
- C1 -
-
3L9L
1
KAPCA_HUMAN
B:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
362
Blastp_CBE
57.25
41%
-67
- C1 -
-
3L9M
1
KAPCA_HUMAN
B:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
351
Blastp_CBE
56.92
42%
-66
- C1 -
-
3AG9
1
KAPCA_BOVIN
B:
[44-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
62
Blastp_CBE
56.89
46%
-53
- C1 -
-
3ZH8
4
KPCI_HUMAN
A:
[6-342]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
V
---
G
----TEDYLFQV-
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-----------------------------------------
449
Blastp_CBE
56.79
37%
-33
- C1 -
-
6BDL
1
B:
[32-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
---
L
K
S
---
E
E--
S
----
K
T
F
A
M
K
I
L
K
K
R
-
H
I
V
-
D
T
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
---
Q
-
G
A
-
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
-
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
H
R
-
G
Y
A
K
L
V
D
F
G
F
A
K
K
-----
I
G
F
G
--
K
--
K
T
----
W
F
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
-----
G
-
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
S
G
P
D
P
M
---
K
T
Y
N
I
---------
I
-
L
R
GI
D
M
I
----
E
F
--
P
-----
K
K
---
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
-
G
N
L
--
K
--
N
-
G
V
K
-
D
--
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
S
P
T
D
T
S
N
F
D
S
------------------------------------------------
72
Blastp_CBE
56.79
46%
-69
- C1 -
-
5LIH
3
KPCI_HUMAN
A:
[6-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
--------
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
V
--------NTEDYLFQV
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-----------------------------------------
393
Blastp_CBE
56.74
41%
-70
- C1 -
-
4Z83
2
KAPCA_BOVIN
E:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
99
Blastp_CBE
56.64
46%
-12
- C1 -
-
2Z7S
1
KS6A1_HUMAN
A:
[24-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
-
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
KVT
R
P
D
---
S
---
G
----
H
L
Y
A
M
K
V
L
-
K
-------------------
I
L
---
A
-
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
-----------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
-----
G
-
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
L
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
--
G
--
P
-
D
G
A
E
E
--
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------
77
Blastp_CBE
56.63
47%
-56
- C1 -
-
5LI1
2
KPCI_HUMAN
A:
[11-319]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
V
--------EDYLFQV--
I
-
L
E
--
K
Q
I
----
R
I
--------
P
R
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-----------------------------------------
455
Blastp_CBE
56.51
38%
-87
- C1 -
-
1UVR
8
PDPK1_HUMAN
A:
[8-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
----
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
71
Blastp_CBE
56.51
46%
-73
- C1 -
-
5LIH
3
KPCI_HUMAN
B:
[6-314]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
----------
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
---------EDYLFQV--
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-----------------------------------------
60
Blastp_CBE
56.47
46%
-46
- C1 -
-
3ZH8
3
KPCI_HUMAN
C:
[6-341]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
V
---
G
----TEDYLFQV-
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-----------------------------------------
450
Blastp_CBE
56.45
37%
-34
- C1 -
-
6BDL
1
KGP1_HUMAN
A:
[32-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
---
L
K
S
---
E
E--
S
----
K
T
F
A
M
K
I
L
K
K
R
-
H
I
V
-
D
T
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
---
Q
-
G
A
-
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
-
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
H
R
-
G
Y
A
K
L
V
D
F
G
F
A
K
K
-----
I
G
F
G
--
K
--
K
T
----
W
F
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
-----
G
-
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
S
G
P
D
P
M
---
K
T
Y
N
I
---------
I
-
L
R
GI
D
M
I
----
E
F
--
P
-----
K
K
---
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
-
G
N
L
--
K
--
N
-
G
V
K
-
D
--
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
S
P
T
D
T
S
N
F
D
S
------------------------------------------------
337
Blastp_CBE
56.43
41%
-73
- C1 -
-
5VIB
1
KAPCA_BOVIN
A:
[44-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
---------
F
D
D
-
Y
E
E
E
E
I
R
----------------------------------------
444
Blastp_CBE
56.36
37%
-30
- C1 -
-
6C0T
3
A:
[32-327]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
K
-
L
S
D
F
N
I
I
D
T
L
G
V
G
-
G
F
G
R
V
E
L
V
Q
---
L
K
S
---
E
E--
S
----
K
T
F
A
M
K
I
L
K
K
R
-
H
I
V
-
D
T
R
Q
Q
E
H
I
R
S
E
K
Q
I
M
---
Q
-
G
A
-
H
S
D
F
I
V
R
L
Y
R
T
F
K
D
S
K
-
Y
L
Y
M
L
M
E
A
C
L
G
G
E
L
W
T
I
L
R
D
-
R
G
S
F
E
D
S
T
T
R
F
Y
T
A
C
V
V
E
A
F
A
Y
L
H
S
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
L
I
L
D
H
R
-
G
Y
A
K
L
V
D
F
G
F
A
K
K
-----
I
G
F
G
--
K
--
K
T
----
W
F
C
G
T
P
E
Y
V
A
P
E
I
I
L
N
K
-----
G
-
H
D
I
S
A
D
Y
W
S
L
G
I
L
M
Y
E
L
L
T
G
S
-
P
P
F
S
G
P
D
P
M
---
K
T
Y
N
I
---------
I
-
L
R
GI
D
M
I
----
E
F
--
P
-----
K
K
---
I
A
K
N
A
A
N
L
I
K
K
L
C
R
D
N
P
S
E
--
R
L
-
G
N
L
--
K
--
N
-
G
V
K
-
D
--
I
Q
K
H
K
W
F
E
G
F
N
---
W
E
G
L
R
K
G
T
L
T
P
P
I
I
P
S
V
A
S
P
T
D
T
S
N
F
D
S
------------------------------------------------
338
Blastp_CBE
56.34
41%
-71
- C1 -
-
5VI9
1
KAPCA_BOVIN
A:
[38-351]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
S
E
P
H
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
----
N
F
D
D
-
Y
E
---------------------------------------------
61
Blastp_CBE
56.14
46%
-50
- C1 -
-
3ZH8
5
KPCI_HUMAN
B:
[6-342]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
D
L
L
R
V
I
G
R
G
-
S
Y
A
K
V
L
L
V
R
---
L
K
K
---
T
---
D
----
R
I
Y
A
M
K
V
V
K
K
E
-
L
V
N
-
D
D
E
D
I
D
W
V
Q
T
E
K
H
V
F
--
E
Q
-
A
S
-
N
H
P
F
L
V
G
L
H
S
C
F
Q
T
E
S
-
R
L
F
F
V
I
E
Y
V
N
G
G
D
L
M
F
H
M
Q
R
-
Q
R
K
L
P
E
E
H
A
R
F
Y
S
A
E
I
S
L
A
L
N
Y
L
H
E
-
R
G
-
I
I
Y
R
D
L
K
L
D
N
V
L
L
D
S
E
-
G
H
I
K
L
T
D
Y
G
M
C
K
E
----
G
L
R
P
G
-
D
---
T
T
----
S
F
C
G
T
P
N
Y
I
A
P
E
I
L
R
G
E
-----
D
-
Y
G
F
S
V
D
W
W
A
L
G
V
L
M
F
E
M
M
A
G
R
-
S
P
F
---
D
I
V
---
G
----TEDYLFQV-
I
-
L
E
--
K
Q
I
----
R
I
--
P
-----
R
S
---
L
S
V
K
A
A
S
V
L
K
S
F
L
N
K
D
P
K
E
--
R
L
-
G
-
C
HP
Q
--
T
-
G
F
A
-
D
--
I
Q
G
H
P
F
F
R
N
V
D
---
W
D
M
M
E
Q
K
Q
V
V
P
P
F
K
P
N
I
S
G
E
F
G
L
D
N
F
D
S
Q
F
T
N
E
P
V
-----------------------------------------
76
Blastp_CBE
55.59
47%
-5
- C1 -
-
3A60
1
KS6B1_HUMAN
A:
[13-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M------------
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
------------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------
75
Blastp_CBE
55.29
47%
-9
- C1 -
-
3A60
1
KS6B1_HUMAN
B:
[13-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
-----------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
-----------------
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
------------------------------------------------------------
123
Blastp_CBE
55.09
45%
-3
- C1 -
-
6G78
1
KS6A6_HUMAN
B:
[22-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
E
K
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
K
T
---
G
PDA
G
----
Q
L
Y
A
M
K
V
L
-
K
K
-
A
S
L
-
K
V
R
D
--------
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----
S
V
-----------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
N
---
E
T
M
N
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
-
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------
74
Blastp_CBE
55.01
47%
-2
- C1 -
-
3A61
1
KS6B1_HUMAN
A:
[15-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
----------------
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
---------------------------
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------
456
Blastp_CBE
54.90
38%
-85
- C1 -
-
1H1W
9
PDPK1_HUMAN
A:
[8-286]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
----
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
491
Blastp_CBE
54.88
38%
-91
- C1 -
-
3HRC
1
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
----
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
79
Blastp_CBE
54.76
47%
-1
- C1 -
-
3WF9
2
KS6B1_HUMAN
A:
[15-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
-
D
-
G
T
--
V
T
----
H
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
-----------------------------------------------------------
511
Blastp_CBE
54.58
38%
-87
- C1 -
-
3RWQ
4
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
----
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
80
Blastp_CBE
54.47
47%
3
- C1 -
-
3WF8
2
KS6B1_HUMAN
A:
[15-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
A
M
I
V
R
-
N
A
K
D
T
A
H
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
-
D
-
G
T
--
V
T
----
H
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
-----------------------------------------------------------
100
Blastp_CBE
54.44
46%
3
- C1 -
-
2Z7R
1
KS6A1_HUMAN
A:
[21-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
S
E
K
A
D
-
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
KVT
R
P
D
---
S
---
G
----
H
L
Y
A
M
K
V
L
-
K
K
-
A
T
L
-
K
V
-----------
I
L
---
A
-
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
-----------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
-----
G
-
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
L
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
--
G
--
P
-
D
G
A
E
E
--
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------
83
Blastp_CBE
54.42
47%
-21
- C1 -
-
3WF5
1
KS6B1_HUMAN
A:
[15-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
-
D
-
G
T
--
V
T
----
H
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
---------------------------------------------------------
101
Blastp_CBE
54.35
46%
-12
- C1 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[24-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
D
-
P
S
H
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
KVT
R
P
D
---
S
---
G
----
H
L
Y
A
M
K
V
L
---------------------
I
L
---
A
-
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
-
E
V
M
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
G
L
D
H
L
H
S
-
L
G
-
I
I
Y
R
D
L
K
P
E
N
I
L
L
D
E
E
-
G
H
I
K
L
T
D
F
G
L
S
K
E
-----------------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
Q
-----
G
-
H
S
H
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
-
L
P
F
Q
G
K
D
R
K
---
E
T
M
T
L
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
--
G
--
P
-
D
G
A
E
E
--
I
K
R
H
V
F
Y
S
T
I
D
---
W
N
K
L
Y
R
R
E
I
K
P
P
F
K
P
-------------------------------------------------------------
235
Blastp_CBE
53.75
42%
-26
- C1 -
-
3PVB
1
KAPCA_MOUSE
A:
[28-329]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
124
Blastp_CBE
53.65
45%
-5
- C1 -
-
6G78
1
KS6A6_HUMAN
A:
[22-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
E
K
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
K
T
---
G
PDA
G
----
Q
L
Y
A
M
K
V
L
-
K
K
-
A
S
L
-
K
V
R
D
--------
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----
S
V
D
Q
---------------
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
N
---
E
T
M
N
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
-
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------
318
Blastp_CBE
53.40
42%
-25
- C1 -
-
5N3D
2
KAPCA_CRIGR
A:
[34-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
205
Blastp_CBE
53.24
42%
-29
- C1 -
-
4DH3
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
486
Blastp_CBE
53.01
38%
-61
- C1 -
-
4RQK
5
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
194
Blastp_CBE
52.97
42%
-22
- C1 -
-
4DG3
1
KAPCA_MOUSE
E:
[54-360]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
A
V
S
I
-------------------------------------
328
Blastp_CBE
52.87
42%
-28
- C1 -
-
5N1M
3
KAPCA_CRIGR
A:
[34-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
218
Blastp_CBE
52.88
42%
-27
- C1 -
-
4IB3
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
325
Blastp_CBE
52.87
42%
-27
- C1 -
-
5N33
3
KAPCA_CRIGR
A:
[34-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
90
Blastp_CBE
52.83
49%
-4
- C1 -
-
4RLO
4
KS6B1_HUMAN
B:
[3-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
-----------------------------
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
------------------
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
-------------------------------------------------------------
326
Blastp_CBE
52.79
42%
-33
- C1 -
-
5N1O
2
KAPCA_CRIGR
A:
[32-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
-
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
484
Blastp_CBE
52.73
38%
-61
- C1 -
-
4RRV
3
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
279
Blastp_CBE
52.71
42%
-29
- C1 -
-
6I2A
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
481
Blastp_CBE
52.69
38%
-63
- C1 -
-
5LVM
2
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
323
Blastp_CBE
52.60
42%
-28
- C1 -
-
5N37
6
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
482
Blastp_CBE
52.56
38%
-61
- C1 -
-
5LVL
5
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
480
Blastp_CBE
52.54
38%
-62
- C1 -
-
5LVN
2
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
475
Blastp_CBE
52.53
38%
-74
- C1 -
-
5LVP
1
PDPK1_HUMAN
D:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
299
Blastp_CBE
52.51
42%
-27
- C1 -
-
5OK3
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
224
Blastp_CBE
52.44
42%
-26
- C1 -
-
4IAI
2
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
286
Blastp_CBE
52.43
42%
-29
- C1 -
-
6EMB
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
82
Blastp_CBE
52.42
47%
-18
- C1 -
-
3WF6
1
KS6B1_HUMAN
A:
[15-304]
-----------------------------------------------------------------------------------------------------------------------------------------------------------
K
I
R
-
P
E
C
F
E
L
L
R
V
L
G
K
G
-
G
Y
G
K
V
F
Q
V
R
---
K
V
T
---
G
ANT
G
----
K
I
F
A
M
K
V
L
K
K
-------------
T
K
A
E
R
N
I
L
---
E
-
E
V
-
K
H
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
-
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
E
R
-
E
G
I
F
M
E
D
T
A
C
F
Y
L
A
E
I
S
M
A
L
G
H
L
H
Q
-
K
G
-
I
I
Y
R
D
L
K
P
E
N
I
M
L
N
H
Q
-
G
H
V
K
L
T
D
F
G
L
C
K
E
----
S
I
H
-
D
-
G
T
--
V
T
----
H
F
C
G
T
I
E
Y
M
A
P
E
I
L
M
R
S
-----
G
-
H
N
R
A
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
-
P
P
F
T
G
E
N
R
K
---
K
T
I
D
K
---------
I
-
L
K
--
C
K
L
----
N
L
--
P
-----
P
Y
---
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
A
S
--
R
L
-
G
-
A
--
G
P-
G
-
D
A
G
-
E
--
V
Q
A
H
P
F
F
R
H
I
N
---
W
E
E
L
L
A
R
K
V
E
P
P
F
K
P
L
L
Q
S
---------------------------------------------------------
225
Blastp_CBE
52.37
42%
-29
- C1 -
-
4IAF
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
538
Blastp_CBE
52.33
38%
-59
- C1 -
-
4A07
3
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
K
S
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
327
Blastp_CBE
52.28
42%
-26
- C1 -
-
5N1N
2
KAPCA_CRIGR
A:
[35-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
321
Blastp_CBE
52.25
42%
-25
- C1 -
-
5N3A
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
490
Blastp_CBE
52.24
38%
-62
- C1 -
-
3HRF
4
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
320
Blastp_CBE
52.23
42%
-26
- C1 -
-
5N3B
2
KAPCA_CRIGR
A:
[35-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
206
Blastp_CBE
52.21
42%
-33
- C1 -
-
4DH1
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
215
Blastp_CBE
52.19
42%
-30
- C1 -
-
4XW6
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
203
Blastp_CBE
52.18
42%
-28
- C1 -
-
4DH7
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
483
Blastp_CBE
52.14
38%
-62
- C1 -
-
5ACK
4
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
294
Blastp_CBE
52.13
42%
-30
- C1 -
-
5OUC
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
226
Blastp_CBE
52.11
42%
-27
- C1 -
-
4IAD
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
322
Blastp_CBE
52.04
42%
-27
- C1 -
-
5N39
5
KAPCA_CRIGR
A:
[34-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
479
Blastp_CBE
52.01
38%
-65
- C1 -
-
5LVO
4
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
209
Blastp_CBE
51.95
42%
-28
- C1 -
-
2QCS
5
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
287
Blastp_CBE
51.90
42%
-32
- C1 -
-
6EMA
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
329
Blastp_CBE
51.91
42%
-27
- C1 -
-
5N1L
4
KAPCA_CRIGR
A:
[34-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
275
Blastp_CBE
51.90
42%
-29
- C1 -
-
6I2H
1
?
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
317
Blastp_CBE
51.85
42%
-27
- C1 -
-
5N3E
3
KAPCA_CRIGR
A:
[35-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
237
Blastp_CBE
51.85
42%
-28
- C1 -
-
4O21
1
KAPCA_MOUSE
A:
[25-326]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
223
Blastp_CBE
51.84
42%
-30
- C1 -
-
4IAK
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
515
Blastp_CBE
51.72
38%
-73
- C1 -
-
5HKM
1
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
301
Blastp_CBE
51.74
42%
-28
- C1 -
-
5O0E
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
208
Blastp_CBE
51.74
42%
-28
- C1 -
-
4DG0
2
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
217
Blastp_CBE
51.72
42%
-24
- C1 -
-
4XW4
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
283
Blastp_CBE
51.68
42%
-29
- C1 -
-
6ERT
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
232
Blastp_CBE
51.68
42%
-27
- C1 -
-
4DFX
5
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
214
Blastp_CBE
51.68
42%
-27
- C1 -
-
6E21
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
399
Blastp_CBE
51.65
44%
-36
- C1 -
-
4CRS
1
A:
[13-318]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
R
C
C
A
V
L
L
R
G
-
H
F
G
K
V
L
L
A
E
---
Y
K
N
---
T
---
N
----
E
M
F
A
I
K
A
L
K
K
G
-
D
I
V
-
A
R
D
E
V
D
S
L
M
C
E
K
R
I
F
ET
V
N
-
S
V
-
R
H
P
F
L
V
N
L
F
A
C
F
Q
T
K
E
-
H
V
C
F
V
M
E
Y
A
A
G
G
D
L
M
M
H
I
H
T
-
D
V
F
E
P
--
R
A
V
F
Y
A
A
C
V
V
L
G
L
Q
Y
L
H
E
-
H
K
-
I
V
Y
R
D
L
K
L
D
N
L
L
L
D
T
E
-
G
F
V
K
I
A
D
F
G
L
C
K
E
----
G
M
G
Y
G
-
D
R
--
T
S
-----
F
C
G
T
P
E
F
L
A
P
E
V
L
T
E
T
-----
S
-
Y
T
R
A
V
D
W
W
G
L
G
V
L
I
Y
E
M
L
V
G
E
-
S
P
F
P
G
D
D
E
E
---
E
V
F
D
S
---------
I
-
V
N
--
D
E
V
----
R
Y
--
P
-----
R
F
---
L
S
T
E
A
I
S
I
M
R
R
L
L
R
R
N
P
E
R
--
R
L
-
G
-
A
--
S
--
E
K
D
A
E
-
D
--
V
K
K
H
P
F
F
R
L
I
D
---
W
S
A
L
M
D
K
K
V
K
P
P
F
I
P
T
I
R
G
R
E
D
V
S
N
F
D
D
E
F
T
S
E
A
------------------------------------------
222
Blastp_CBE
51.63
42%
-27
- C1 -
-
4IAY
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
290
Blastp_CBE
51.64
42%
-29
- C1 -
-
6EH3
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
220
Blastp_CBE
51.63
42%
-28
- C1 -
-
4IB0
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
474
Blastp_CBE
51.60
38%
-63
- C1 -
-
4XX9
6
PDPK1_HUMAN
A:
[32-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
221
Blastp_CBE
51.54
42%
-32
- C1 -
-
4IAZ
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
488
Blastp_CBE
51.52
38%
-59
- C1 -
-
4A06
3
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
200
Blastp_CBE
51.50
42%
-26
- C1 -
-
4WBB
1
KAPCA_MOUSE
B:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
201
Blastp_CBE
51.49
42%
-31
- C1 -
-
4HPU
2
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
127
Blastp_CBE
51.48
45%
-13
- C1 -
-
6G76
1
KS6A6_HUMAN
B:
[22-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
E
K
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
K
T
---
G
PDA
G
----
Q
L
Y
A
M
K
V
L
-
K
K
-
A
S
L
-
K
V
---------
R
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
---
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----
S
V
D
------------------
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
N
---
E
T
--------------------
L
----
G
M
--
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
-
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------
324
Blastp_CBE
51.47
42%
-25
- C1 -
-
5N36
2
KAPCA_CRIGR
A:
[34-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
477
Blastp_CBE
51.44
38%
-67
- C1 -
-
5LVP
1
PDPK1_HUMAN
B:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
512
Blastp_CBE
51.40
38%
-72
- C1 -
-
5HO8
1
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
--------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
537
Blastp_CBE
51.36
38%
-66
- C1 -
-
4AW0
4
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
K
S
S
-
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
274
Blastp_CBE
51.33
42%
-27
- C1 -
-
6EM7
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
296
Blastp_CBE
51.29
42%
-28
- C1 -
-
5OTG
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
199
Blastp_CBE
51.16
42%
-26
- C1 -
-
5JR7
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
219
Blastp_CBE
51.09
42%
-26
- C1 -
-
4IB1
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
229
Blastp_CBE
51.04
42%
-28
- C1 -
-
1L3R
3
KAPCA_MOUSE
E:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
202
Blastp_CBE
51.04
42%
-28
- C1 -
-
4DH8
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
216
Blastp_CBE
50.95
42%
-29
- C1 -
-
4XW5
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
316
Blastp_CBE
50.88
42%
-29
- C1 -
-
5N3F
3
KAPCA_CRIGR
A:
[33-336]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
--
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
-
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
300
Blastp_CBE
50.87
42%
-27
- C1 -
-
5O5M
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
--
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
489
Blastp_CBE
50.81
38%
-57
- C1 -
-
3RCJ
1
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
319
Blastp_CBE
50.81
42%
-24
- C1 -
-
5N3C
2
KAPCA_CRIGR
A:
[35-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
204
Blastp_CBE
50.78
42%
-27
- C1 -
-
4DH5
1
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
227
Blastp_CBE
50.77
42%
-25
- C1 -
-
4IAC
1
KAPCA_MOUSE
A:
[39-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
230
Blastp_CBE
50.73
42%
-27
- C1 -
-
4X6R
5
KAPCA_MOUSE
A:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
310
Blastp_CBE
50.69
42%
-20
- C1 -
-
5N3L
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
309
Blastp_CBE
50.61
42%
-24
- C1 -
-
5N3M
6
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
297
Blastp_CBE
50.61
42%
-31
- C1 -
-
5OT3
3
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
298
Blastp_CBE
50.58
42%
-25
- C1 -
-
5OL3
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
331
Blastp_CBE
50.52
42%
-21
- C1 -
-
5N1G
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
211
Blastp_CBE
50.47
42%
-26
- C1 -
-
3X2W
1
KAPCA_MOUSE
A:
[40-341]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
478
Blastp_CBE
50.44
38%
-77
- C1 -
-
5LVP
1
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
---------------
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
284
Blastp_CBE
50.41
42%
-27
- C1 -
-
6ERS
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
401
Blastp_CBE
50.38
42%
-34
- C1 -
-
3BWJ
2
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
288
Blastp_CBE
50.37
42%
-27
- C1 -
-
6EM6
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
281
Blastp_CBE
50.25
42%
-31
- C1 -
-
6ERW
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
----
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
273
Blastp_CBE
50.25
42%
-32
- C1 -
-
5NW8
2
KAPCA_CRIGR
A:
[34-335]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
228
Blastp_CBE
50.25
42%
-30
- C1 -
-
3TNQ
1
KAPCA_MOUSE
B:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
402
Blastp_CBE
50.20
42%
-34
- C1 -
-
1XH4
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
485
Blastp_CBE
50.19
38%
-58
- C1 -
-
4RQV
6
PDPK1_HUMAN
A:
[33-308]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
213
Blastp_CBE
50.14
42%
-33
- C1 -
-
3X2U
1
KAPCA_MOUSE
A:
[40-341]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
514
Blastp_CBE
50.05
38%
-74
- C1 -
-
5HNG
1
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
-------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
397
Blastp_CBE
50.03
42%
-31
- C1 -
-
4WB7
1
KAPCA_HUMAN
B:
[98-389]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
292
Blastp_CBE
50.02
42%
-26
- C1 -
-
6EGW
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
-
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
-
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
277
Blastp_CBE
49.99
42%
-28
- C1 -
-
6I2C
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
---
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
407
Blastp_CBE
49.92
42%
-34
- C1 -
-
2JDS
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
513
Blastp_CBE
49.93
38%
-76
- C1 -
-
5HO7
1
PDPK1_HUMAN
A:
[31-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
L
E
K
R
-
H
I
I
-
K
E
N
K
V
P
Y
V
T
R
E
R
D
V
M
---
S
-
R
L
-
D
H
P
F
F
V
K
L
Y
F
T
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
-------------
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
Y
---
L
I
F
Q
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
312
Blastp_CBE
49.92
42%
-22
- C1 -
-
5N3J
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
307
Blastp_CBE
49.90
42%
-20
- C1 -
-
5N3P
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
413
Blastp_CBE
49.87
42%
-36
- C1 -
-
1XH7
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
332
Blastp_CBE
49.86
42%
-22
- C1 -
-
5N1F
3
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
314
Blastp_CBE
49.83
42%
-20
- C1 -
-
5N3H
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
389
Blastp_CBE
49.76
41%
-31
- C1 -
-
4WB6
1
KAPCA_HUMAN
A:
[43-339]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
R
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
-
Y
E
E
E
E
I
R
V
S
I
-------------------------------------
280
Blastp_CBE
49.73
42%
-26
- C1 -
-
6ESA
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
311
Blastp_CBE
49.70
42%
-21
- C1 -
-
5N3K
5
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
198
Blastp_CBE
49.69
42%
-29
- C1 -
-
5JR7
1
KAPCA_MOUSE
C:
[33-334]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
308
Blastp_CBE
49.57
42%
-19
- C1 -
-
5N3O
6
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
442
Blastp_CBE
49.56
41%
-30
- C1 -
-
2UVY
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
291
Blastp_CBE
49.50
42%
-32
- C1 -
-
6EH2
2
KAPCA_CRIGR
A:
[36-340]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
----
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
--
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
315
Blastp_CBE
49.48
42%
-20
- C1 -
-
5N3G
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
330
Blastp_CBE
49.47
42%
-21
- C1 -
-
5N1H
3
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
306
Blastp_CBE
49.45
42%
-21
- C1 -
-
5N3Q
4
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
302
Blastp_CBE
49.40
42%
-25
- C1 -
-
5NTJ
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
---
Y
E
E
E
E
-------------------------------------------
285
Blastp_CBE
49.40
42%
-21
- C1 -
-
6EMD
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
276
Blastp_CBE
49.35
42%
-21
- C1 -
-
6I2D
1
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
304
Blastp_CBE
49.33
42%
-20
- C1 -
-
5N3S
5
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
409
Blastp_CBE
49.22
42%
-31
- C1 -
-
3ZO2
4
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
387
Blastp_CBE
49.22
42%
-32
- C1 -
-
4WB5
1
KAPCA_HUMAN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
212
Blastp_CBE
49.25
42%
-25
- C1 -
-
3X2V
1
KAPCA_MOUSE
A:
[40-341]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
Q
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
S
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
128
Blastp_CBE
49.22
45%
-23
- C1 -
-
6G76
2
KS6A6_HUMAN
A:
[22-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------
G
Y
E
K
A
D
-
P
A
Q
F
E
L
L
K
V
L
G
Q
G
-
S
F
G
K
V
F
L
V
R
---
K
K
T
---
G
PDA
G
----
Q
L
Y
A
M
K
V
L
-
K
K
-
A
S
L
-
K
V
R
D
--------
D
I
L
--
V
E
--
V
-
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
-
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
-
E
V
L
F
T
E
E
D
V
K
F
Y
L
A
E
L
A
L
A
L
D
H
L
H
Q
-
L
G
-
I
V
Y
R
D
L
K
P
E
N
I
L
L
D
E
I
-
G
H
I
K
L
T
D
F
G
L
S
K
E
----
S
V
D
-
Q
-
E
K
--
K
A
----
Y
F
C
G
T
V
E
Y
M
A
P
E
V
V
N
R
R
-----
G
-
H
S
Q
S
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
-
L
P
F
Q
G
K
D
R
N
---
E
T
M
N
M
---------
I
-
L
K
--
A
K
L
----
G
M
--
P
-----
Q
F
---
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
A
N
--
R
L
-
G
-
S
-----
E
-
G
V
E
-
E
--
I
K
R
H
L
F
F
A
N
I
D
---
W
D
K
L
Y
K
R
E
V
Q
P
P
F
K
P
-------------------------------------------------------------
289
Blastp_CBE
49.11
42%
-21
- C1 -
-
6EM2
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
278
Blastp_CBE
48.93
42%
-22
- C1 -
-
6I2B
2
KAPCA_CRIGR
A:
[36-337]
------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
Q
N
T
-
A
Q
-
L
D
H
F
D
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
--
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
398
Blastp_CBE
48.92
42%
-31
- C1 -
-
4WB7
1
DNJB1_HUMAN (first)
A:
[98-389]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
440
Blastp_CBE
48.74
41%
-27
- C1 -
-
2UW0
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
405
Blastp_CBE
48.72
42%
-30
- C1 -
-
3ZO3
9
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
443
Blastp_CBE
48.58
41%
-28
- C1 -
-
6FRX
1
KAPCA_HUMAN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
R
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
Q
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
K
V
A
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
-----
F
D
D
Y
E
E
E
E
-------------------------------------------
400
Blastp_CBE
48.56
42%
-31
- C1 -
-
3KKV
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
429
Blastp_CBE
48.53
41%
-36
- C1 -
-
4C38
4
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
435
Blastp_CBE
48.49
41%
-26
- C1 -
-
2VNW
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
434
Blastp_CBE
48.44
41%
-26
- C1 -
-
2VNY
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
403
Blastp_CBE
48.47
42%
-30
- C1 -
-
1Q8W
1
KAPCA_BOVIN
A:
[43-334]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
388
Blastp_CBE
48.44
42%
-30
- C1 -
-
4WB8
2
KAPCA_HUMAN
A:
[30-321]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
K
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
432
Blastp_CBE
48.30
41%
-27
- C1 -
-
2VO6
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
436
Blastp_CBE
48.25
41%
-31
- C1 -
-
2UW8
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
406
Blastp_CBE
48.21
42%
-32
- C1 -
-
3ZO1
7
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
426
Blastp_CBE
48.16
41%
-34
- C1 -
-
4C36
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
404
Blastp_CBE
47.96
42%
-33
- C1 -
-
5VHB
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
L
I
D
Q
Q
-
G
Y
I
Q
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
-----
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
427
Blastp_CBE
47.87
41%
-32
- C1 -
-
4C35
2
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
430
Blastp_CBE
47.83
41%
-34
- C1 -
-
4C37
2
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
441
Blastp_CBE
47.62
41%
-28
- C1 -
-
2UVZ
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
433
Blastp_CBE
47.61
41%
-29
- C1 -
-
2VO3
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
508
Blastp_CBE
47.47
37%
-9
- C1 -
-
5MRD
5
PDPK1_HUMAN
A:
[27-307]
------------------------------------------------------------------------------------------------------------------------------------------------------------
S
K
R
P
E
D
F
K
F
G
K
I
L
G
E
G
-
S
F
S
T
V
V
L
A
R
---
E
L
A
---
T
---
S
----
R
E
Y
A
I
K
I
V
E
K
R
-
H
V
N
-
K
E
N
K
I
P
Y
V
Q
R
E
K
D
V
M
--
S
R
--
L
-
D
H
P
F
F
V
K
L
Y
F
C
F
Q
D
D
E
-
K
L
Y
F
G
L
S
Y
A
K
N
G
E
L
L
K
Y
I
R
K
-
I
G
S
F
D
E
T
C
T
R
F
Y
T
A
E
I
V
S
A
L
E
Y
L
H
G
-
K
G
-
I
I
H
R
D
L
K
P
E
N
I
L
L
N
E
D
-
M
H
I
Q
I
T
D
F
G
T
A
K
V
----
L
S
P
E
S
K
Q
A
--
R
A
----
N
F
V
G
T
A
Q
Y
V
S
P
E
L
L
T
E
K
-----
S
-
A
C
K
S
S
D
L
W
A
L
G
C
I
I
Y
Q
L
V
A
G
L
-
P
P
F
R
A
G
N
E
G
---
L
I
F
A
K
---------
I
-
I
K
--
L
E
Y
----
D
F
--
P
-----
E
K
---
F
F
P
K
A
R
D
L
V
E
K
L
L
V
L
D
A
T
K
--
R
L
-
G
-
C
--
E
EM
E
-
G
Y
G
-
P
--
L
K
A
H
P
F
F
E
S
V
T
---
W
E
N
L
H
Q
Q
T
P
P
------------------------------------------------------------------
428
Blastp_CBE
47.41
41%
-36
- C1 -
-
4C34
3
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
Y
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
L
E
Y
L
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
-
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
438
Blastp_CBE
47.36
41%
-29
- C1 -
-
2UW5
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------
437
Blastp_CBE
46.07
41%
-28
- C1 -
-
2UW6
1
KAPCA_BOVIN
A:
[44-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
E
R
I
K
T
L
G
T
G
-
S
F
G
R
V
M
L
V
K
---
H
M
E
---
T
---
G
----
N
H
Y
A
M
K
I
L
D
K
Q
-
K
V
V
-
K
L
K
Q
I
E
H
T
L
N
E
K
R
I
L
---
Q
-
A
V
-
N
F
P
F
L
T
K
L
E
F
S
F
K
D
N
S
-
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
H
L
R
R
-
I
G
R
F
E
P
H
-
A
R
F
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
S
-
L
D
-
L
I
Y
R
D
L
K
P
E
N
L
M
I
D
Q
Q
-
G
Y
I
K
V
T
D
F
G
F
A
K
R
--------
V
-
K
G
--
R
T
----
W
L
C
G
T
P
E
Y
L
A
P
E
I
I
L
S
K
-----
G
-
Y
N
K
A
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
-
P
P
F
F
A
D
Q
P
I
---
Q
I
Y
E
K
---------
I
-
V
S
--
G
K
V
----
R
F
--
P
-----
S
H
---
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
--
R
F
-
G
N
L
--
K
--
N
-
G
V
N
-
D
--
I
K
N
H
K
W
F
A
T
T
D
---
W
I
A
I
Y
Q
R
K
V
E
A
P
F
I
P
K
F
K
G
P
G
D
T
S
N
F
D
D
Y
E
E
E
E
-------------------------------------------