@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : ST17B_HUMAN: (2020-09-22 )
MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSLPNPHELVSDLLC
Atome Classification :
(190 SA)
.........10........20..--......30.......-.40....---....50........60.-----------...------..-----.----.70------....---.-.---...80---........90........100.......110.......120.......--130.....---..140.......150........160..-..--...170..----.....180...--.-...190..-..-...200.....------.------.210...-....220.......230....-..-.240......-...250.......260.......270......-.280----...-----...---..-290.-......300.---......310.......320.......330.......340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MSRRRF
D
C
R
SISGLLTTTPQI
P
I
--
K
M
ENFN
N
F
Y
I
L
TSKE-LGR
G
K
F
A
---
V
V
R
Q
C
I
S
KST
G
Q
E
Y
A
A
K
-----------
F
L
K
------
K
R-----R----RG-------Q
D
C
R
---
A
-
E
---
I
L
H
E
I
---
A
V
L
E
L
A
K
SCP
R
V
I
N
L
H
E
V
YENTS
E
I
I
L
I
L
E
YAAGG
E
I
F
S
L
C
L
P
E
L
A
E
M
--VSE
N
D
V
I
R
---
L
I
K
Q
I
L
E
G
V
Y
Y
LH-QN
N
I
V
H
L
DLKPQ
N
I
-
L
L
--
S
SIYPLG
D
----
I
K
I
V
DFGMSRK--I-G
H
A
C
E
L
R
E
-
I
M-G
T
P
E
Y
L
A
P
E
IL------N------YDPITT
A
-
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
THTSPFV-GE-DN--Q
E
T
Y
L
N
-
I
S
Q
V
N
VDY
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
VKNP-EKR-----
P
T
A
-----
E
I
C
---
L
S
-
H
S
W
L
-
Q
QWD
F
E
NLFH---PEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIP
E
D
S
S
M
V
S
K
R
FRFDDSLP
N
P
H
E
L
V
S
D
LLC
395
HHSearch
97.52
100%
-155
- C1 -
-
6QF4
2
ST17B_HUMAN
A:
[22-306]
-------------------------
S
M
E
N
F
N
N
F
Y
I
L
T
S
K
E
-
L
G
R
G
K
F
A
---
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
-----------
F
L
K
------
K
R
-----
R
----
R
G
-------
Q
D
C
R
---
A
-
E
---
I
L
H
E
I
---
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
L
A
E
M
--
V
S
E
N
D
V
I
R
---
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
-
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
L
--
S
S
I
Y
P
L
G
D
----
I
K
I
V
D
F
G
M
S
R
K
--
I
-
G
H
A
C
-----
I
M
-
G
T
P
E
Y
L
A
P
E
I
L
------
N
------
Y
D
P
I
T
T
A
-
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
-
G
E
-
D
N
--
Q
E
T
Y
L
N
-
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
-
E
K
R
-----
P
T
A
-----
E
I
C
---
L
S
-
H
S
W
L
-
Q
Q
W
D
F
E
N
L
F
H
---
P
E
E
T
S
----------------------------------------------------------------
3
PsiBlast_PDB
97.39
100%
-157
- C1 -
-
6QF4
2
ST17B_HUMAN
A:
[23-306]
--------------------------
M
E
N
F
N
N
F
Y
I
L
T
S
K
E
-
L
G
R
G
K
F
A
---
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
-----------
F
L
K
------
K
R
-----
R
----
R
G
-------
Q
D
C
R
---
A
-
E
---
I
L
H
E
I
---
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
L
A
E
M
--
V
S
E
N
D
V
I
R
---
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
-
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
L
--
S
S
I
Y
P
L
G
D
----
I
K
I
V
D
F
G
M
S
R
K
--
I
-
G
H
A
C
-----
I
M
-
G
T
P
E
Y
L
A
P
E
I
L
------
N
------
Y
D
P
I
T
T
A
-
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
-
G
E
-
D
N
--
Q
E
T
Y
L
N
-
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
-
E
K
R
-----
P
T
A
-----
E
I
C
---
L
S
-
H
S
W
L
-
Q
Q
W
D
F
E
N
L
F
H
---
P
E
E
T
S
----------------------------------------------------------------
1
PsiBlast_PDB
94.38
100%
-151
- C1 -
-
3LM0
2
ST17B_HUMAN
A:
[23-302]
--------------------------
M
E
N
F
N
N
F
Y
I
L
T
S
K
E
-
L
G
R
G
K
F
A
---
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
-----------
F
L
K
------
K
R
-----
R
----
R
G
-------
Q
D
C
R
---
A
-
E
---
I
L
H
E
I
---
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
L
A
E
M
--
V
S
E
N
D
V
I
R
---
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
-
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
L
--
S
S
I
Y
P
L
G
D
----
I
K
I
V
D
F
G
M
S
R
K
-------------
I
M
-
G
T
P
E
Y
L
A
P
E
I
L
------
N
------
Y
D
P
I
T
T
A
-
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
-
G
E
-
D
N
--
Q
E
T
Y
L
N
-
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
-
E
K
R
-----
P
T
A
-----
E
I
C
---
L
S
-
H
S
W
L
-
Q
Q
W
D
F
E
N
L
F
H
---
P
--------------------------------------------------------------------
2
PsiBlast_PDB
93.67
100%
-151
- C1 -
-
3LM5
1
ST17B_HUMAN
A:
[23-299]
--------------------------
M
E
N
F
N
N
F
Y
I
L
T
S
K
E
-
L
G
R
G
K
F
A
---
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
-----------
F
L
K
------
K
R
-----
R
----
R
G
-------
Q
D
C
R
---
A
-
E
---
I
L
H
E
I
---
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
L
-
E
M
--
V
S
E
N
D
V
I
R
---
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
-
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
L
--
S
S
I
Y
P
L
G
D
----
I
K
I
V
D
F
G
M
S
R
K
-------------
I
M
-
G
T
P
E
Y
L
A
P
E
I
L
------
N
------
Y
D
P
I
T
T
A
-
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
-
G
E
-
D
N
--
Q
E
T
Y
L
N
-
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
-
E
K
R
-----
P
T
A
-----
E
I
C
---
L
S
-
H
S
W
L
-
Q
Q
W
D
F
E
N
L
--------------------------------------------------------------------------
396
HHSearch
93.37
100%
-149
- C1 -
-
3LM5
1
ST17B_HUMAN
A:
[22-299]
-------------------------
S
M
E
N
F
N
N
F
Y
I
L
T
S
K
E
-
L
G
R
G
K
F
A
---
V
V
R
Q
C
I
S
K
S
T
G
Q
E
Y
A
A
K
-----------
F
L
K
------
K
R
-----
R
----
R
G
-------
Q
D
C
R
---
A
-
E
---
I
L
H
E
I
---
A
V
L
E
L
A
K
S
C
P
R
V
I
N
L
H
E
V
Y
E
N
T
S
E
I
I
L
I
L
E
Y
A
A
G
G
E
I
F
S
L
C
L
P
E
L
-
E
M
--
V
S
E
N
D
V
I
R
---
L
I
K
Q
I
L
E
G
V
Y
Y
L
H
-
Q
N
N
I
V
H
L
D
L
K
P
Q
N
I
-
L
L
--
S
S
I
Y
P
L
G
D
----
I
K
I
V
D
F
G
M
S
R
K
-------------
I
M
-
G
T
P
E
Y
L
A
P
E
I
L
------
N
------
Y
D
P
I
T
T
A
-
T
D
M
W
N
I
G
I
I
A
Y
M
L
L
T
H
T
S
P
F
V
-
G
E
-
D
N
--
Q
E
T
Y
L
N
-
I
S
Q
V
N
V
D
Y
S
E
E
T
F
S
S
V
S
Q
L
A
T
D
F
I
Q
S
L
L
V
K
N
P
-
E
K
R
-----
P
T
A
-----
E
I
C
---
L
S
-
H
S
W
L
-
Q
Q
W
D
F
E
N
L
--------------------------------------------------------------------------
402
HHSearch
70.44
35%
-132
- C1 -
-
2BDW
-
KCC2D_CAEEL
B:
[9-274]
-----------------------------
F
S
D
N
Y
D
V
K
-
E
E
-
L
G
K
G
A
F
S
---
V
V
R
R
C
V
H
K
T
T
G
L
E
F
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
F
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
K
L
-
Q
H
P
N
I
V
R
L
H
D
S
I
Q
E
E
S
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
F
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
I
A
Y
C
H
-
S
N
G
I
V
H
R
N
L
K
P
E
N
L
-
L
L
--
A
S
K
A
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
-
N
D
S
E
A
W
H
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
K
------
K
D
P
Y
S
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
A
Q
-
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
S
L
I
D
S
M
L
T
V
N
P
-
K
K
R
-----
I
T
A
-----
D
Q
A
---
L
K
-
V
P
W
I
-
C
N
R
-------------------------------------------------------------------------------
415
Fugue
69.02
30%
-85
- C1 -
-
1KOB
1
?
A:
[23-374]
-
I
N
D
Y
D
K
F
Y
E
D
I
W
K
K
Y
V
P
Q
P
V
E
V
--
K
Q
G
S
V
Y
D
Y
Y
D
I
L
-
E
E
-
L
G
S
G
A
F
G
---
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
-----------
F
I
N
------
T
P
-----
Y
-------------
P
L
D
K
---
Y
-
T
---
V
K
N
E
I
---
S
I
M
N
Q
L
H
-
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
E
D
Y
K
M
---
S
E
A
E
V
I
N
---
Y
M
R
Q
A
C
E
G
L
K
H
M
H
-
E
H
S
I
V
H
L
D
I
K
P
E
N
I
-
M
C
--
E
T
-
K
K
A
S
S
----
V
K
I
I
D
F
G
L
A
T
K
--
L
-
N
P
D
E
I
V
K
V
-
T
T
-
A
T
A
E
F
A
A
P
E
I
V
------
D
------
R
E
P
V
G
F
Y
-
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
-
G
E
-
D
D
--
L
E
T
L
Q
N
-
V
K
R
C
D
W
E
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
-
R
K
R
-----
L
T
V
-----
H
D
A
---
L
E
-
H
P
W
L
-
K
G
D
H
S
N
L
T
S
R
---
I
P
S
S
R
Y
N
K
I
R
Q
K
I
K
E
K
Y
A
D
W
P
A
P
Q
P
A
I
G
R
I
A
N
F
S
S
L
R
K
H
R
P
Q
E
Y
Q
I
Y
D
S
Y
F
D
R
K
E
A
-------------
118
Blastp_CBE
66.56
36%
-102
- C1 -
-
2VZ6
1
KCC2A_HUMAN
A:
[20-282]
-----------------------------
F
Q
S
M
Y
Q
L
F
-
E
E
-
L
G
K
--
F
S
---
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
L
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
E
G
E
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
S
K
R
-----
I
T
A
-----
A
E
A
---
L
K
-
H
P
W
I
-----------------------------------------------------------------------------------
117
Blastp_CBE
66.23
36%
-100
* C1 *
-
2VZ6
3
KCC2A_HUMAN
B:
[20-282]
-----------------------------
F
Q
S
M
Y
Q
L
F
-
E
E
-
L
G
K
G
A
F
S
---
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
L
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
E
G
E
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
S
K
R
-----
I
T
A
-----
A
E
A
---
L
K
-
H
P
W
I
-----------------------------------------------------------------------------------
106
Blastp_CBE
66.23
36%
-80
- C1 -
-
6AYW
2
KCC2D_HUMAN
B:
[19-288]
--------------------------------------
E
E
-
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
S
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
S
E
A
---
L
K
-
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
397
HHSearch
65.65
35%
-132
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[19-281]
----------------------------
E
L
Y
E
K
Y
M
I
A
-
E
D
-
L
G
R
G
E
F
G
---
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
-----------
F
V
K
------
V
K
-----
G
----
T
----------
D
Q
---
V
-
L
---
V
K
K
E
I
---
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
-
A
F
E
--
L
N
E
R
E
I
V
S
---
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
-
S
H
N
I
G
H
F
D
I
R
P
E
N
I
-
I
Y
--
Q
T
R
R
-
S
S
T
----
I
K
I
I
E
F
G
Q
A
R
Q
--
L
-
K
P
G
D
N
F
R
L
-
L
F
-
T
A
P
E
Y
Y
A
P
E
V
H
------
Q
------
H
D
V
V
S
T
A
-
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
-
A
E
-
T
N
--
Q
Q
I
I
E
N
-
I
M
N
A
E
Y
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
-
K
S
R
-----
M
T
A
-----
S
E
A
---
L
Q
-
H
P
W
L
-
K
Q
K
-------------------------------------------------------------------------------
399
HHSearch
65.35
34%
-138
- C1 -
-
4JNW
-
TITIN_HUMAN
A:
[4-267]
---------------------------
K
E
L
Y
E
K
Y
M
I
A
-
E
D
-
L
G
R
G
E
F
G
---
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
-----------
F
V
K
------
V
K
-----
G
----
T
----------
D
Q
---
V
-
L
---
V
K
K
E
I
---
S
I
L
N
I
A
-
R
H
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
-
A
F
E
--
L
N
E
R
E
I
V
S
---
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
-
S
H
N
I
G
H
F
D
I
R
P
E
N
I
-
I
Y
--
Q
T
R
R
-
S
S
T
----
I
K
I
I
E
F
G
Q
A
R
Q
--
L
-
K
P
G
D
N
F
R
L
-
L
F
-
T
A
P
E
Y
Y
A
P
E
V
H
------
Q
------
H
D
V
V
S
T
A
-
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
-
A
E
-
T
N
--
Q
Q
I
I
E
N
-
I
M
N
A
E
Y
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
-
K
S
R
-----
M
T
A
-----
S
E
A
---
L
Q
-
H
P
W
L
-
K
Q
K
-------------------------------------------------------------------------------
105
Blastp_CBE
65.29
36%
-76
- C1 -
-
6BAB
2
KCC2D_MOUSE
A:
[19-288]
--------------------------------------
E
E
-
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
S
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
S
E
A
---
L
K
-
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
110
Blastp_CBE
65.24
36%
-91
- C1 -
-
2WEL
7
KCC2D_HUMAN
A:
[10-279]
--------------------------------------
E
E
-
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
S
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
S
E
A
---
L
K
-
H
P
W
I
C
Q
R
----
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
102
Blastp_CBE
64.94
36%
-75
- C1 -
-
6BAB
1
KCC2D_MOUSE
D:
[19-288]
--------------------------------------
E
E
-
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
S
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
S
E
A
---
L
K
-
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
107
Blastp_CBE
64.83
36%
-81
- C1 -
-
6AYW
2
KCC2D_HUMAN
A:
[19-288]
--------------------------------------
E
E
-
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
S
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
S
E
A
---
L
K
-
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
108
Blastp_CBE
64.82
36%
-77
- C1 -
-
5VLO
2
KCC2D_HUMAN
B:
[19-288]
--------------------------------------
E
E
-
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
S
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
S
E
A
---
L
K
-
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
416
Fugue
64.68
29%
-86
- C1 -
-
1TKI
-
TITIN_HUMAN
A:
[18-338]
---------------------------
K
E
L
Y
E
K
Y
M
-
I
A
E
D
-
L
G
R
G
E
F
G
---
I
V
H
R
C
V
E
T
S
S
K
K
T
Y
M
A
K
-----------
F
V
K
------
V
K
-----
G
--------------
T
D
Q
---
V
-
L
---
V
K
K
E
I
---
S
I
L
N
I
A
R
H
-
R
N
I
L
H
L
H
E
S
F
E
S
M
E
E
L
V
M
I
F
E
F
I
S
G
L
D
I
F
E
R
I
N
T
S
A
F
E
L
---
N
E
R
E
I
V
S
---
Y
V
H
Q
V
C
E
A
L
Q
F
L
H
-
S
H
N
I
G
H
F
D
I
R
P
E
N
I
-
I
Y
--
Q
T
-
R
R
S
S
T
----
I
K
I
I
E
F
G
Q
A
R
Q
--
L
-
K
P
G
D
N
F
R
L
-
L
F
-
T
A
P
E
Y
Y
A
P
E
V
H
------
Q
------
H
D
V
V
S
T
A
-
T
D
M
W
S
L
G
T
L
V
Y
V
L
L
S
G
I
N
P
F
L
-
A
E
-
T
N
--
Q
Q
I
I
E
N
-
I
M
N
A
E
Y
T
F
D
E
E
A
F
K
E
I
S
I
E
A
M
D
F
V
D
R
L
L
V
K
E
R
-
K
S
R
-----
M
T
A
-----
S
E
A
---
L
Q
-
H
P
W
L
-
K
Q
------
K
I
---
E
R
V
S
T
K
V
I
R
T
L
K
H
R
R
Y
Y
H
T
L
I
K
K
D
L
N
M
V
V
S
A
A
R
I
S
C
G
G
A
I
R
S
Q
K
G
V
S
V
A
K
V
K
V
A
S
I
-------------
119
Blastp_CBE
64.48
35%
-80
- C1 -
-
2V7O
3
KCC2G_HUMAN
A:
[37-306]
--------------------------------------
E
E
-
L
G
K
G
-
F
S
---
V
V
R
R
C
V
K
K
T
P
T
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
H
Q
I
L
E
S
V
N
H
I
H
-
Q
H
D
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
C
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
E
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
K
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
D
Q
A
---
L
K
-
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
92
Blastp_CBE
64.45
47%
-11
- C1 -
-
2A2A
3
DAPK2_HUMAN
D:
[4-280]
---------------------
P
F
--
K
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
-----------
F
I
K
------
K
R
QSRAS
R
----
R
G
-------
V
-
S
R
---
E
-
E
---
I
E
R
E
V
---
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
S
--
L
S
E
E
E
A
T
S
---
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
I
P
I
P
H
----
I
K
L
I
D
F
G
L
A
H
E
--
I
-
E
D
G
V
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
-
R
K
R
-----
L
T
I
-----
Q
E
A
---
L
R
-
H
P
W
I
-
T
P
V
D
------------------------------------------------------------------------------
145
Blastp_CBE
64.39
33%
-89
- C1 -
-
3BHH
1
KCC2B_HUMAN
A:
[10-279]
--------------------------------------
E
D
-
I
G
----
S
---
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
C
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
E
A
Y
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
K
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
H
E
A
---
L
K
-
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
104
Blastp_CBE
64.08
36%
-80
- C1 -
-
6BAB
2
KCC2D_MOUSE
B:
[19-288]
--------------------------------------
E
E
-
L
G
----
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
S
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
S
E
A
---
L
K
-
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
112
Blastp_CBE
64.07
36%
-77
- C1 -
-
2VN9
2
KCC2D_HUMAN
A:
[10-279]
--------------------------------------
E
E
-
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
S
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
S
E
A
---
L
K
-
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
89
Blastp_CBE
63.85
47%
-9
- C1 -
-
2CKE
1
DAPK2_HUMAN
C:
[4-280]
---------------------
P
F
--
K
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
-----------
F
I
K
------
K
R
QSRAS
R
----
R
G
-------
V
-
S
R
---
E
-
E
---
I
E
R
E
V
---
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
S
--
L
S
E
E
E
A
T
S
---
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
I
P
I
P
H
----
I
K
L
I
D
F
G
L
A
H
E
--
I
-
E
D
G
V
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
-
R
K
R
-----
L
T
I
-----
Q
E
A
---
L
R
-
H
P
W
I
-
T
P
V
D
------------------------------------------------------------------------------
144
Blastp_CBE
63.84
33%
-90
- C1 -
-
3BHH
1
KCC2B_HUMAN
B:
[10-279]
--------------------------------------
E
D
-
I
G
K
---
S
---
V
V
R
R
C
V
K
L
C
T
G
H
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
S
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
C
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
E
A
Y
G
K
P
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
K
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
H
E
A
---
L
K
-
H
P
W
V
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
90
Blastp_CBE
63.83
47%
-8
- C1 -
-
2CKE
1
DAPK2_HUMAN
B:
[4-280]
---------------------
P
F
--
K
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
-----------
F
I
K
------
K
R
QSRAS
R
----
R
G
-------
V
-
S
R
---
E
-
E
---
I
E
R
E
V
---
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
S
--
L
S
E
E
E
A
T
S
---
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
I
P
I
P
H
----
I
K
L
I
D
F
G
L
A
H
E
--
I
-
E
D
G
V
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
-
R
K
R
-----
L
T
I
-----
Q
E
A
---
L
R
-
H
P
W
I
-
T
P
V
D
------------------------------------------------------------------------------
91
Blastp_CBE
63.77
47%
-9
- C1 -
-
2CKE
1
DAPK2_HUMAN
A:
[4-280]
---------------------
P
F
--
K
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
-----------
F
I
K
------
K
R
QSRAS
R
----
R
G
-------
V
-
S
R
---
E
-
E
---
I
E
R
E
V
---
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
S
--
L
S
E
E
E
A
T
S
---
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
I
P
I
P
H
----
I
K
L
I
D
F
G
L
A
H
E
--
I
-
E
D
G
V
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
-
R
K
R
-----
L
T
I
-----
Q
E
A
---
L
R
-
H
P
W
I
-
T
P
V
D
------------------------------------------------------------------------------
63
Blastp_CBE
63.60
48%
-58
- C1 -
-
5VJA
2
DAPK3_HUMAN
A:
[10-270]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
-----------
F
I
K
------
K
R
----------
R
R
-------
G
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
A
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
T
I
-----
A
Q
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
111
Blastp_CBE
63.48
36%
-76
- C1 -
-
2VN9
1
KCC2D_HUMAN
B:
[10-279]
--------------------------------------
E
E
-
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
S
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
S
E
A
---
L
K
-
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
76
Blastp_CBE
63.46
47%
-7
- C1 -
-
2YAA
1
DAPK2_MOUSE
B:
[5-280]
----------------------
F
--
K
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
-----------
F
I
K
------
K
R
QSRAS
R
----
R
G
-------
V
-
C
R
---
E
-
E
---
I
E
R
E
V
---
S
I
L
R
Q
V
L
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
S
--
L
S
E
E
E
A
T
S
---
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
I
P
I
P
H
----
I
K
L
I
D
F
G
L
A
H
E
--
I
-
E
D
G
V
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
-
R
K
R
-----
L
T
I
-----
Q
E
A
---
L
R
-
H
P
W
I
-
T
P
V
D
------------------------------------------------------------------------------
103
Blastp_CBE
63.40
36%
-76
- C1 -
-
6BAB
2
KCC2D_MOUSE
C:
[19-288]
--------------------------------------
E
E
-
L
G
K
G
A
F
S
---
V
V
R
R
C
M
K
----
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
S
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
S
E
A
---
L
K
-
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
88
Blastp_CBE
63.25
47%
-7
- C1 -
-
2CKE
1
DAPK2_HUMAN
D:
[4-280]
---------------------
P
F
--
K
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
-----------
F
I
K
------
K
R
QSRAS
R
----
R
G
-------
V
-
S
R
---
E
-
E
---
I
E
R
E
V
---
S
I
L
R
Q
V
L
H
H
-
N
V
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
S
--
L
S
E
E
E
A
T
S
---
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
I
P
I
P
H
----
I
K
L
I
D
F
G
L
A
H
E
--
I
-
E
D
G
V
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
I
T
S
V
S
Y
D
F
D
E
E
F
F
S
H
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
-
R
K
R
-----
L
T
I
-----
Q
E
A
---
L
R
-
H
P
W
I
-
T
P
V
D
------------------------------------------------------------------------------
109
Blastp_CBE
63.17
36%
-79
- C1 -
-
5VLO
2
KCC2D_HUMAN
A:
[19-288]
--------------------------------------
E
E
-
L
G
---
F
S
---
V
V
R
R
C
M
K
I
P
T
G
Q
E
Y
A
A
K
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
F
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
L
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
S
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
M
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
A
K
R
-----
I
T
A
-----
S
E
A
---
L
K
-
H
P
W
I
C
Q
R
S
T
V
A
S
M
M
H
---
R
Q
E
T
-----------------------------------------------------------------
96
Blastp_CBE
63.11
40%
-49
- C1 -
-
2X4F
3
MYLK4_HUMAN
B:
[78-346]
--------------------
V
T
A
--
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
G
G
G
--
G
---
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
-----------
I
I
K
------
T
R
-----------
G
-------
M
K
D
K
---
E
-
E
---
V
K
N
E
I
---
S
V
M
N
Q
L
D
H
A
-
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
-
S
Y
N
--
L
T
E
L
D
T
I
L
---
F
M
K
Q
I
C
E
G
I
R
H
M
H
-
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
-
L
C
--
V
N
-
R
D
A
K
Q
----
I
K
I
I
D
F
G
L
A
R
R
--
Y
-
K
P
R
E
K
L
K
V
-
N
F
-
G
T
P
E
F
L
A
P
E
V
V
------
N
------
Y
D
F
V
S
F
P
-
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
-
G
D
-
N
D
--
A
E
T
L
N
N
-
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
-
S
W
R
-----
I
S
A
-----
S
E
A
---
L
K
-
H
P
W
L
-----------------------------------------------------------------------------------
62
Blastp_CBE
63.09
48%
-64
- C1 -
-
5VJA
2
DAPK3_HUMAN
B:
[10-270]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
-----------
F
I
K
------
K
-----------
R
R
-------
G
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
A
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
T
I
-----
A
Q
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
15
PsiBlast_PDB
62.74
48%
5
- C1 -
-
2YAK
1
DAPK1_HUMAN
A:
[4-278]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
-------------------------------------------------------------------------------
41
Blastp_CBE
62.64
49%
3
- C1 -
-
1JKL
1
DAPK1_HUMAN
A:
[3-291]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
77
Blastp_CBE
62.59
47%
-8
- C1 -
-
2YAA
1
DAPK2_MOUSE
A:
[5-280]
----------------------
F
--
K
Q
Q
K
V
E
D
F
Y
D
I
-
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
-----------
F
I
K
------
K
R
QSRAS
R
----
R
G
-------
V
-
C
R
---
E
-
E
---
I
E
R
E
V
---
S
I
L
R
Q
V
L
H
-
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
Q
K
--
E
S
--
L
S
E
E
E
A
T
S
---
F
I
K
Q
I
L
D
G
V
N
Y
L
H
-
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
I
P
I
P
H
----
I
K
L
I
D
F
G
L
A
H
E
--
I
-
E
D
G
V
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
I
T
A
V
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
-
R
K
R
-----
L
T
I
-----
Q
E
A
---
L
R
-
H
P
W
I
-
T
P
V
D
------------------------------------------------------------------------------
5
PsiBlast_PDB
62.43
48%
-1
- C1 -
-
3DFC
1
DAPK1_HUMAN
B:
[4-292]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
K
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
34
Blastp_CBE
62.21
49%
-7
- C1 -
-
5AUW
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
------
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
54
Blastp_CBE
62.14
49%
1
- C1 -
-
3GU6
1
DAPK1_HUMAN
A:
[4-292]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
V
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
11
PsiBlast_PDB
62.11
48%
9
- C1 -
-
6FHB
2
DAPK1_HUMAN
A:
[7-282]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
39
Blastp_CBE
62.06
49%
-4
- C1 -
-
3EHA
1
DAPK1_HUMAN
A:
[3-291]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
56
Blastp_CBE
62.03
49%
1
- C1 -
-
3GU4
1
DAPK1_HUMAN
A:
[4-292]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
V
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
31
Blastp_CBE
61.82
49%
-7
- C1 -
-
5AUZ
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
----
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
50
Blastp_CBE
61.76
49%
9
- C1 -
-
4TXC
7
DAPK1_HUMAN
A:
[23-296]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
36
Blastp_CBE
61.76
49%
2
- C1 -
-
4YPD
1
DAPK1_HUMAN
A:
[3-291]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
135
Blastp_CBE
61.66
35%
-92
- C1 -
-
3SOA
1
KCC2A_HUMAN
A:
[17-271]
--------------------------------------
E
E
-
L
G
K
G
--
S
---
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
-----------
I
I
N
------
T
K
-----
K
----
L
S
-------
A
R
D
H
---
Q
-
K
---
L
E
R
E
A
---
R
I
C
R
L
L
K
H
-
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
Y
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
A
V
L
H
C
H
-
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
-
L
L
--
A
S
K
L
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
E
G
E
Q
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
R
------
K
D
P
Y
G
K
P
-
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
Q
Q
-
I
K
A
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
-
S
K
R
-----
I
T
A
-----
A
E
A
---
L
K
-
H
P
W
I
-----------------------------------------------------------------------------------
26
Blastp_CBE
61.47
49%
-8
- C1 -
-
5AV4
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
----
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
55
Blastp_CBE
61.45
49%
4
- C1 -
-
3GU5
1
DAPK1_HUMAN
A:
[4-292]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
V
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
42
Blastp_CBE
61.39
49%
2
- C1 -
-
1JKK
1
DAPK1_HUMAN
A:
[3-292]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
-------------------------------------------------------------------------------
20
PsiBlast_PDB
61.34
48%
-9
- C1 -
-
5AUU
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
----
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
53
Blastp_CBE
61.24
49%
5
- C1 -
-
3GU7
1
DAPK1_HUMAN
A:
[4-292]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
V
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
58
Blastp_CBE
61.19
48%
3
- C1 -
-
3GUB
1
DAPK1_HUMAN
A:
[4-293]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
10
PsiBlast_PDB
61.19
48%
7
- C1 -
-
2W4K
1
DAPK1_HUMAN
A:
[4-279]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
35
Blastp_CBE
61.16
49%
-3
- C1 -
-
5AUV
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
44
Blastp_CBE
61.07
49%
4
- C1 -
-
3F5U
1
DAPK1_HUMAN
A:
[4-292]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
-
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
43
Blastp_CBE
61.06
49%
6
- C1 -
-
1IG1
1
DAPK1_HUMAN
A:
[3-291]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
27
Blastp_CBE
61.05
49%
-2
- C1 -
-
5AV3
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
40
Blastp_CBE
60.99
49%
-2
- C1 -
-
3EH9
1
DAPK1_HUMAN
A:
[3-291]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS-
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
38
Blastp_CBE
60.93
49%
-1
- C1 -
-
3F5G
1
DAPK1_HUMAN
A:
[3-291]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
37
Blastp_CBE
60.85
49%
1
- C1 -
-
4YO4
1
DAPK1_HUMAN
A:
[3-292]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
28
Blastp_CBE
60.75
49%
-2
- C1 -
-
5AV2
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
33
Blastp_CBE
60.65
49%
-1
- C1 -
-
5AUX
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
52
Blastp_CBE
60.58
49%
11
- C1 -
-
6QMO
7
DAPK1_HUMAN
A:
[7-282]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
59
Blastp_CBE
60.57
48%
11
- C1 -
-
3GU8
1
DAPK1_HUMAN
A:
[4-293]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
G
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
49
Blastp_CBE
60.48
49%
-1
- C1 -
-
4PF4
6
DAPK1_HUMAN
A:
[5-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
---------------------------------------------------------------------------------
18
PsiBlast_PDB
60.46
48%
5
- C1 -
-
6QN4
4
DAPK1_HUMAN
A:
[7-280]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
7
PsiBlast_PDB
60.44
48%
5
- C1 -
-
4B4L
3
DAPK1_HUMAN
A:
[7-281]
-------------------------
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
97
Blastp_CBE
60.43
40%
-48
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[78-346]
--------------------
V
T
A
--
K
Q
G
A
V
N
S
F
Y
T
V
S
K
T
E
I
L
-----
G
---
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
-----------
I
I
K
------
T
R
-----------
G
-------
M
K
D
K
---
E
-
E
---
V
K
N
E
I
---
S
V
M
N
Q
L
D
H
A
-
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
-
S
Y
N
--
L
T
E
L
D
T
I
L
---
F
M
K
Q
I
C
E
G
I
R
H
M
H
-
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
-
L
C
--
V
N
-
R
D
A
K
Q
----
I
K
I
I
D
F
G
L
A
R
R
--
Y
-
K
P
R
E
K
L
K
V
-
N
F
-
G
T
P
E
F
L
A
P
E
V
V
------
N
------
Y
D
F
V
S
F
P
-
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
-
G
D
-
N
D
--
A
E
T
L
N
N
-
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
-
S
W
R
-----
I
S
A
-----
S
E
A
---
L
K
-
H
P
W
L
-----------------------------------------------------------------------------------
57
Blastp_CBE
60.43
48%
9
- C1 -
-
2XUU
1
DAPK1_HUMAN
A:
[4-279]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
A
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
14
PsiBlast_PDB
60.39
48%
5
- C1 -
-
2Y0A
1
DAPK1_HUMAN
A:
[4-279]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
19
PsiBlast_PDB
60.34
48%
-2
- C1 -
-
5AUT
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
----
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
30
Blastp_CBE
60.30
49%
1
- C1 -
-
5AV0
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
48
Blastp_CBE
60.28
49%
-0
- C1 -
-
2W4J
1
DAPK1_HUMAN
A:
[4-276]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
---------------------------------------------------------------------------------
46
Blastp_CBE
59.95
49%
2
- C1 -
-
1WVY
1
DAPK1_HUMAN
A:
[4-276]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
---------------------------------------------------------------------------------
21
Blastp_CBE
59.93
49%
-88
- C1 -
-
3ZXT
1
DAPK1_HUMAN
D:
[7-276]
---------------------------
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
-----------------------------
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
--------
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
---------------------------------------------------------------------------------
272
Blastp_CBE
59.75
33%
-25
- C1 -
-
6C9H
2
AAPK1_HUMAN
A:
[16-339]
---------------------------------
Y
I
L
-
G
D
T
-
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
-----------
I
L
N
------
R
Q
-----
K
I---
R
S
-------
L
D
V
V
---
G
-
K
---
I
R
R
E
I
---
Q
N
L
K
L
F
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
R
--
L
D
E
K
E
S
R
R
---
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
--
D
A
H
M
---
N
----
A
K
I
A
D
F
G
L
S
N
M
--
M
-
S
D
G
E
F
L
R
T
-
S
C
-
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-
D
H
--
V
P
T
L
F
K
-
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
---
V
I
S
L
L
K
H
M
L
Q
V
D
P
-
M
K
R
-----
A
T
I
-----
K
D
I
---
R
E
-
H
E
W
F
-
K
Q
-
D
L
P
K
Y
L
F
---
P
E
D
P
S
Y
S
S
T
M
I
D
---------------------------------------------------------
32
Blastp_CBE
59.56
49%
3
- C1 -
-
5AUY
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
---
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
8
PsiBlast_PDB
59.40
48%
6
- C1 -
-
4UV0
1
DAPK1_HUMAN
A:
[5-281]
---------------------
V
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
113
Blastp_CBE
58.98
39%
-124
- C1 -
-
2W4O
1
KCC4_HUMAN
A:
[49-309]
---------------------------
D
A
L
S
D
F
F
E
V
E
S
-
E
-
L
G
R
G
A
T
S
---
I
V
Y
R
C
K
Q
K
G
T
Q
K
P
Y
A
L
K
-----------
V
L
K
------
K
---------------------------------
I
-------
G
V
L
-
L
R
L
S
H
P
N
I
I
K
L
K
E
I
F
E
T
P
T
E
I
S
L
V
L
E
L
V
T
G
G
E
L
F
D
R
I
V
E
K
--
G
Y
--
Y
S
E
R
D
A
A
D
---
A
V
K
Q
I
L
E
A
V
A
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
--
A
T
P
A
P
D
A
P
----
L
K
I
A
D
F
---------------------
G
T
P
G
Y
C
A
P
E
I
L
------
R
------
G
C
A
Y
G
P
E
-
V
D
M
W
S
V
G
I
I
T
Y
I
L
L
C
G
F
E
P
F
Y
-
D
E
R
G
D
--
Q
F
M
F
R
R
-
I
L
N
C
E
Y
Y
F
I
S
P
W
W
D
E
V
S
L
N
A
K
D
L
V
R
K
L
I
V
L
D
P
-
K
K
R
-----
L
T
T
-----
F
Q
A
---
L
Q
-
H
P
W
V
-----------------------------------------------------------------------------------
45
Blastp_CBE
58.56
49%
8
- C1 -
-
1P4F
1
DAPK1_HUMAN
A:
[3-292]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
-----------
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
--
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
K
D
------------------------------------------------------------------------------
202
Blastp_CBE
58.43
36%
-134
- C1 -
-
2JAM
3
KCC1G_HUMAN
A:
[17-265]
-----------------------------------------
L
G
S
G
A
F
S
---
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
-----------
C
I
K
------
K
----------------------
S
S
---
L
-
E
-----
N
E
I
---
A
V
L
K
K
I
K
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--
G
V
--
Y
T
E
K
D
A
S
L
---
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
--
L
T
P
E
E
N
S
K
----
I
M
I
T
D
F
G
L
S
-
K
--
M
-
E
Q
N
G
I
M
S
T
-
A
C
-
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
-
E
E
-
T
E
--
S
K
L
F
E
K
-
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
-
N
E
R
-----
Y
T
C
-----
E
K
A
---
L
S
-
H
P
W
I
-----------------------------------------------------------------------------------
256
Blastp_CBE
57.86
32%
-82
- C1 -
-
2CN5
1
CHK2_HUMAN
A:
[18-302]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
G
A
C
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
R
----------------------------
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
-
G
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
----------------------------------------------------------------
199
Blastp_CBE
57.39
34%
-72
- C1 -
-
4YSJ
1
?
A:
[38-298]
-----------------------------------------
L
G
K
G
S
F
G
---
E
V
I
L
C
K
D
K
V
T
G
Q
E
Y
A
V
K
-----------
V
I
S
------
K
R
---------------------------------
L
L
K
E
---
V
E
L
L
K
K
L
D
H
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
T
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
R
--
F
S
E
V
D
A
A
R
---
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
E
N
K
R
K
D
A
N
----
I
R
I
I
D
F
G
L
S
T
H
--
F
-
E
S
T
K
K
M
K
D
-
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
------
H
GT----
Y
D
E
---
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
-
G
A
-
N
E
--
F
D
I
L
K
K
-
V
E
K
G
K
F
T
F
D
L
P
Q
W
K
K
V
S
E
P
A
K
D
L
I
R
K
M
L
A
Y
V
P
-
T
M
R
-----
I
S
A
-----
R
D
A
---
L
E
-
H
E
W
L
-
K
T
T
D
------------------------------------------------------------------------------
247
Blastp_CBE
57.03
32%
-75
- C1 -
-
4A9R
2
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
----------------------
P
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
-
G
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
253
Blastp_CBE
56.98
32%
-78
- C1 -
-
2WTD
4
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
----------------------
P
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
---
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
218
Blastp_CBE
56.90
32%
-74
- C1 -
-
2YCR
1
CHK2_HUMAN
A:
[12-302]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
---
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
-----------------------------
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
-
G
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
K
P
Q
----------------------------------------------------------
245
Blastp_CBE
56.79
32%
-73
- C1 -
-
4A9T
4
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
---
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
----------------------
P
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
-
G
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
25
Blastp_CBE
56.79
49%
9
- C1 -
-
6AAR
1
DAPK1_HUMAN
A:
[4-277]
----------------------
F
--
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
-----------
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
F
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
P
--------------------------------------------------------------------------------
248
Blastp_CBE
56.51
32%
-70
- C1 -
-
2XM9
1
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
---
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
----------------------
P
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
-
G
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
246
Blastp_CBE
56.31
32%
-78
- C1 -
-
4A9S
1
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
----------------------
P
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
---
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
240
Blastp_CBE
56.14
32%
-82
- C1 -
-
4BDD
3
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
-----------------------------
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
---
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
201
Blastp_CBE
56.11
36%
-127
- C1 -
-
2JAM
3
KCC1G_HUMAN
B:
[17-265]
-----------------------------------------
L
G
S
G
A
F
S
---
E
V
F
L
V
K
Q
R
L
T
G
K
L
F
A
L
K
-----------
C
I
K
------
K
----------------------
S
S
---
L
-
E
-----
N
E
I
---
A
V
L
K
K
I
K
H
-
E
N
I
V
T
L
E
D
I
Y
E
S
T
T
H
Y
Y
L
V
M
Q
L
V
S
G
G
E
L
F
D
R
I
L
E
R
--
G
V
--
Y
T
E
K
D
A
S
L
---
V
I
Q
Q
V
L
S
A
V
K
Y
L
H
-
E
N
G
I
V
H
R
D
L
K
P
E
N
L
-
L
Y
--
L
T
P
E
E
N
S
K
----
I
M
I
T
D
F
G
L
S
-
K
--
M
-
E
Q
N
G
I
M
S
T
-
A
C
-
G
T
P
G
Y
V
A
P
E
V
L
------
A
------
Q
K
P
Y
S
K
A
-
V
D
C
W
S
I
G
V
I
T
Y
I
L
L
C
G
Y
P
P
F
Y
-
E
E
-
T
E
--
S
K
L
F
E
K
-
I
K
E
G
Y
Y
E
F
E
S
P
F
W
D
D
I
S
E
S
A
K
D
F
I
C
H
L
L
E
K
D
P
-
N
E
R
-----
Y
T
C
-----
E
K
A
---
L
S
-
H
P
W
I
-----------------------------------------------------------------------------------
250
Blastp_CBE
55.92
32%
-72
- C1 -
-
2XBJ
1
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
G
A
-
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
-----------------------
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
---
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
17
PsiBlast_PDB
55.77
48%
-43
- C1 -
-
3ZXT
1
DAPK1_HUMAN
A:
[7-276]
---------------------------
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
T---------------
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
-
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
--------------
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
---------------------------------------------------------------------------------
251
Blastp_CBE
55.70
32%
-79
- C1 -
-
2WTJ
5
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
----------------------
P
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
--
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
252
Blastp_CBE
55.49
32%
-75
- C1 -
-
2WTI
3
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
----------------------
P
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
--
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
244
Blastp_CBE
55.31
32%
-76
- C1 -
-
4A9U
10
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
---------------------
D
P
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
---
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
123
Blastp_CBE
55.19
35%
-28
- C1 -
-
5FG8
3
KCC2A_DROME
A:
[9-276]
--------------------------
C
T
R
F
S
D
N
Y
D
I
-
K
E
E
-
L
G
K
G
A
F
S
---
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
IINTKKLTARD
F
Q
K
------
L
E
-----
R
----
E
A
-------
R
I
C
R
---
K
------
L
H
H
-------------
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
F
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
A
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
H
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
K
------
K
E
P
Y
G
K
S
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
S
Q
-
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
-
N
K
R
-----
I
T
A
-----
A
E
A
---
L
K
-
H
P
W
I
-
C
Q
--------------------------------------------------------------------------------
242
Blastp_CBE
55.02
32%
-82
- C1 -
-
4BDB
10
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
---------------------------
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
--
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
61
Blastp_CBE
54.98
48%
1
- C1 -
-
5VJA
2
DAPK3_HUMAN
C:
[10-270]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
LSS----------
G
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
--
E
K
--
E
S
--
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
--
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
A
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
T
I
-----
A
Q
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
125
Blastp_CBE
54.97
35%
-69
- C1 -
-
4Y5Q
1
?
A:
[30-306]
-----------------------------------------
L
G
K
G
S
F
G
---
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
-----------
V
I
N
------
K
A
-----
S
----
A
K
-------
N
K
D
T
---
S
-
T
---
I
L
R
E
V
---
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
R
--
F
S
E
H
D
A
A
R
---
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
--
E
S
K
E
K
D
C
D
----
I
K
I
I
D
F
G
L
S
T
C
--
F
-
Q
Q
N
T
---
D
-
R
I
-
G
T
A
Y
Y
I
A
P
E
V
L
RG----
T
------
Y
D
E
---
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
-
G
K
-
N
E
--
Y
D
I
L
K
R
-
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
-
S
L
R
-----
I
T
A
-----
T
Q
C
---
L
E
-
H
P
W
I
-
Q
K
Y
S
S
E
----------------------------------------------------------------------------
228
Blastp_CBE
54.94
32%
-76
- C1 -
-
2YIQ
1
CHK2_HUMAN
A:
[12-302]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
----
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
---------------------------------
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
-
G
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
69
Blastp_CBE
54.92
48%
3
- C1 -
-
3BHY
1
DAPK3_HUMAN
A:
[10-270]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
LSSS
R
R
-------
G
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
---------
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
T
I
-----
A
Q
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
122
Blastp_CBE
54.79
35%
-28
- C1 -
-
5H9B
2
KCC2A_DROME
A:
[9-276]
--------------------------
C
T
R
F
S
D
N
Y
D
I
-
K
E
E
-
L
G
K
G
A
F
S
---
I
V
K
R
C
V
Q
K
S
T
G
F
E
F
A
A
K
IINTKKLTARD
F
Q
K
------
L
E
-----
R
----
E
A
-------
R
I
C
R
---
K
------
L
H
H
-------------
P
N
I
V
R
L
H
D
S
I
Q
E
E
N
Y
H
Y
L
V
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
R
--
E
F
--
Y
S
E
A
D
A
S
H
---
C
I
Q
Q
I
L
E
S
V
N
H
C
H
-
Q
N
G
V
V
H
R
D
L
K
P
E
N
L
-
L
L
--
A
S
K
A
K
G
A
A
----
V
K
L
A
D
F
G
L
A
I
E
--
V
Q
G
D
H
Q
A
W
F
G
-
F
A
-
G
T
P
G
Y
L
S
P
E
V
L
------
K
------
K
E
P
Y
G
K
S
-
V
D
I
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
-
D
E
-
D
Q
--
H
R
L
Y
S
Q
-
I
K
A
G
A
Y
D
Y
P
S
P
E
W
D
T
V
T
P
E
A
K
N
L
I
N
Q
M
L
T
V
N
P
-
N
K
R
-----
I
T
A
-----
A
E
A
---
L
K
-
H
P
W
I
-
C
Q
--------------------------------------------------------------------------------
236
Blastp_CBE
54.76
32%
-81
- C1 -
-
4BDH
4
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
-----------------------------
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
-
G
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
277
Blastp_CBE
54.63
33%
-29
- C1 -
-
6C9G
2
AAPK1_HUMAN
A:
[16-462]
---------------------------------
Y
I
L
-
G
D
T
-
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
-----------
I
L
N
------
R
Q
-----
K
I---
R
S
-------
L
D
V
V
---
G
-
K
---
I
R
R
E
I
---
Q
N
L
K
L
F
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
R
--
L
D
E
K
E
S
R
R
---
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
--
D
A
H
M
---
N
----
A
K
I
A
D
F
G
L
S
N
M
--
M
-
S
D
G
E
F
L
R
S
-
C
--
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-
D
H
--
V
P
T
L
F
K
-
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
---
V
I
S
L
L
K
H
M
L
Q
V
D
P
-
M
K
R
-----
A
T
I
-----
K
D
I
---
R
E
-
H
E
W
F
-
K
Q
-
D
L
P
K
Y
L
F
---
P
E
D
P
S
Y
S
S
T
M
I
D
---------------------------------------------------------
126
Blastp_CBE
54.41
35%
-72
- C1 -
-
3NCG
1
?
A:
[30-323]
-----------------------------------------
L
G
K
G
S
F
G
---
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
-----------
V
I
N
------
K
A
-----
S
----
A
K
-------
N
K
D
T
---
S
-
T
---
I
L
R
E
V
---
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
R
--
F
S
E
H
D
A
A
R
---
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
--
E
S
K
E
K
D
C
D
----
I
K
I
I
D
F
G
L
S
T
C
--
F
-
Q
Q
N
T
------
I
-
G
T
A
Y
Y
I
A
P
E
V
L
RG----
T
------
Y
D
E
---
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
-
G
K
-
N
E
--
Y
D
I
L
K
R
-
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
-
S
L
R
-----
I
T
A
-----
T
Q
C
---
L
E
-
H
P
W
I
-
Q
K
Y
S
S
E
----------------------------------------------------------------------------
254
Blastp_CBE
54.39
32%
-69
- C1 -
-
2WTC
1
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
----------------------
P
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
---
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
239
Blastp_CBE
54.18
32%
-82
- C1 -
-
4BDE
5
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
---------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
-----------------------
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
---
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
128
Blastp_CBE
54.03
35%
-70
- C1 -
-
3IGO
8
?
A:
[30-301]
-----------------------------------------
L
G
K
G
S
F
G
---
E
V
L
K
C
K
D
R
I
T
Q
Q
E
Y
A
V
K
-----------
V
I
N
------
K
A
-----
S
----
A
K
-------
N
K
-
T
---
S
-
T
---
I
L
R
E
V
---
E
L
L
K
-
K
L
D
H
P
N
I
M
K
L
F
E
I
L
E
D
S
S
S
F
Y
I
V
G
E
L
Y
T
G
G
E
L
F
D
E
I
I
K
R
--
K
R
--
F
S
E
H
D
A
A
R
---
I
I
K
Q
V
F
S
G
I
T
Y
M
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
--
E
S
K
E
K
D
C
D
----
I
K
I
I
D
F
G
L
S
T
C
--
F
-
Q
Q
N
T
---------
T
A
Y
Y
I
A
P
E
V
L
RG----
T
------
Y
D
E
---
K
-
C
D
V
W
S
A
G
V
I
L
Y
I
L
L
S
G
T
P
P
F
Y
-
G
K
-
N
E
--
Y
D
I
L
K
R
-
V
E
T
G
K
Y
A
F
D
L
P
Q
W
R
T
I
S
D
D
A
K
D
L
I
R
K
M
L
T
F
H
P
-
S
L
R
-----
I
T
A
-----
T
Q
C
---
L
E
-
H
P
W
I
-
Q
K
Y
S
S
E
----------------------------------------------------------------------------
65
Blastp_CBE
53.94
48%
8
- C1 -
-
5A6O
3
DAPK3_HUMAN
A:
[10-270]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
LSSS
R
R
-------
G
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
-----
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
T
I
-----
A
Q
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
276
Blastp_CBE
53.89
33%
-28
- C1 -
-
6C9J
2
AAPK1_HUMAN
A:
[16-462]
---------------------------------
Y
I
L
-
G
D
T
-
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
-----------
I
L
N
------
R
Q
-----
K
I---
R
S
-------
L
D
V
V
---
G
-
K
---
I
R
R
E
I
---
Q
N
L
K
L
F
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
R
--
L
D
E
K
E
S
R
R
---
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
--
D
A
H
M
---
N
----
A
K
I
A
D
F
G
L
S
N
M
--
M
-
S
D
G
E
F
L
R
S
-
C
--
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-
D
H
--
V
P
T
L
F
K
-
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
---
V
I
S
L
L
K
H
M
L
Q
V
D
P
-
M
K
R
-----
A
T
I
-----
K
D
I
---
R
E
-
H
E
W
F
-
K
Q
-
D
L
P
K
Y
L
F
---
P
E
D
P
S
Y
S
S
T
M
I
D
---------------------------------------------------------
233
Blastp_CBE
53.76
32%
-73
- C1 -
-
4BDK
4
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
----
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
-----------------------
A
---
L
-
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
-
G
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
67
Blastp_CBE
53.59
48%
9
- C1 -
-
5A6N
4
DAPK3_HUMAN
A:
[10-270]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
LSSS
R
R
-------
G
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
A
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
T
I
-----
A
Q
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
241
Blastp_CBE
53.41
32%
-75
- C1 -
-
4BDC
2
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
-----------------------------
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
--
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
68
Blastp_CBE
53.38
48%
5
- C1 -
-
3BQR
4
DAPK3_HUMAN
A:
[10-270]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
LSSS
R
R
-------
G
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
A
G
N
---
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
T
I
-----
A
Q
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
23
Blastp_CBE
53.32
49%
8
- C1 -
-
3ZXT
1
DAPK1_HUMAN
B:
[7-276]
---------------------------
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
G
S
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKS-
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
------
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
------------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
-
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
---
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
---------------------------------------------------------------------------------
22
Blastp_CBE
53.32
49%
5
- C1 -
-
3ZXT
1
DAPK1_HUMAN
C:
[5-276]
-------------------------
R
Q
E
N
V
D
D
Y
Y
D
-
T
G
E
E
-
L
--
G
Q
F
A
---
V
V
K
K
C
R
E
K
S
T
G
L
Q
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
TKSS
R
R
-------
G
V
S
R
---
E
-
D
---
I
E
R
E
V
---
S
I
L
K
E
I
Q
H
-
P
N
V
I
T
L
H
E
V
Y
E
N
K
T
D
V
I
L
I
L
E
L
V
A
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
E
E
A
T
E
---
F
L
K
Q
I
L
N
G
V
Y
Y
L
H
-
S
L
Q
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
R
N
V
P
K
P
R
----
I
K
I
I
D
F
G
L
A
H
K
--
I
-
D
-------------
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
D
-
T
K
--
Q
E
T
L
A
N
-
V
S
A
V
N
Y
E
F
E
D
E
Y
F
S
N
T
S
A
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
K
R
-----
M
T
I
-----
Q
D
S
---
L
Q
-
H
P
W
I
-
K
---------------------------------------------------------------------------------
147
Blastp_CBE
53.10
34%
1
- C1 -
-
1PHK
1
PHKG1_RABIT
A:
[25-291]
-----------------------------------------
L
G
R
G
V
S
S
---
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
-----------
I
I
D
------
V
T
-----
G
----
G
G
SFSAEEV
Q
E
L
R
---
E
-
A
---
T
L
K
E
V
---
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
T
----
L
S
E
K
E
T
R
K
---
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
--
D
D
D
M
---
N
----
I
K
L
T
D
F
G
F
S
C
Q
--
L
-
D
P
G
E
K
L
R
E
-
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
ECSMND
N
------
H
P
G
Y
G
K
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
-
H
R
-
K
Q
--
M
L
M
L
R
M
-
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
-
Q
K
R
-----
Y
T
A
-----
E
E
A
---
L
A
-
H
P
F
F
-
Q
Q
Y
V
------------------------------------------------------------------------------
243
Blastp_CBE
53.01
32%
-81
- C1 -
-
4BDA
8
CHK2_HUMAN
A:
[18-308]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
-----------------------------
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
--
E
T
S
L
M
R
T
-
L
C
-
G
T
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
E
S
T
A
L
P
Q
----------------------------------------------------------
64
Blastp_CBE
52.80
48%
10
- C1 -
-
5A6O
2
DAPK3_HUMAN
B:
[10-270]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
LSSS
R
R
-------
G
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
-----
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
T
I
-----
A
Q
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
60
Blastp_CBE
52.74
48%
11
- C1 -
-
5VJA
3
DAPK3_HUMAN
D:
[10-270]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
LS------------
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
---
E
K
--
E
S
--
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
--
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
A
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
T
I
-----
A
Q
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
292
Blastp_CBE
52.63
32%
-26
- C1 -
-
4RER
2
AAPK1_HUMAN
A:
[8-398]
---------------------------------
Y
I
L
-
G
D
T
-
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
-----------
I
L
N
------
R
Q
-----
K
I---
R
S
-------
L
D
V
V
---
G
-
K
---
I
R
R
E
I
---
Q
N
L
K
L
F
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
R
--
L
D
E
K
E
S
R
R
---
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
--
D
A
H
M
---
N
----
A
K
I
A
D
F
G
L
S
N
M
--
M
-
S
D
G
E
F
L
R
S
-
C
--
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-
D
H
--
V
P
T
L
F
K
-
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
---
V
I
S
L
L
K
H
M
L
Q
V
D
P
-
M
K
R
-----
A
S
I
-----
K
D
I
---
R
E
-
H
E
W
F
-
K
Q
-
D
L
P
K
Y
L
F
---
P
E
D
P
S
Y
S
S
T
M
I
D
---------------------------------------------------------
215
Blastp_CBE
52.62
32%
-17
- C1 -
-
2Y7J
1
PHKG2_HUMAN
A:
[102-365]
-----------------------------------------
I
G
R
G
V
S
S
---
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
-----------
I
M
E
VTAERL
S
P
-----
E
----
Q
L
-------
E
E
V
R
---
E
-
A
---
T
R
R
E
T
---
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
----
L
S
E
K
E
T
R
S
---
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
--
D
D
N
M
---
Q
----
I
R
L
S
D
F
G
F
S
C
H
--
L
-
E
P
G
E
K
L
R
E
-
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
------
K
CSMDET
H
P
G
Y
G
K
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
-
H
R
-
R
Q
--
I
L
M
L
R
M
-
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
-
E
A
R
-----
L
T
A
-----
E
Q
A
---
L
Q
-
H
P
F
F
-
E
R
--------------------------------------------------------------------------------
278
Blastp_CBE
52.51
33%
-28
- C1 -
-
6C9F
2
AAPK1_HUMAN
A:
[16-450]
---------------------------------
Y
I
L
-
G
D
T
-
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
-----------
I
L
N
------
R
Q
-----
K
I---
R
S
-------
L
D
V
V
---
G
-
K
---
I
R
R
E
I
---
Q
N
L
K
L
F
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
R
--
L
D
E
K
E
S
R
R
---
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
--
D
A
H
M
---
N
----
A
K
I
A
D
F
G
L
S
N
M
--
M
-
S
D
G
E
F
L
R
S
-
C
--
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-
D
H
--
V
P
T
L
F
K
-
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
---
V
I
S
L
L
K
H
M
L
Q
V
D
P
-
M
K
R
-----
A
T
I
-----
K
D
I
---
R
E
-
H
E
W
F
-
K
Q
-
D
L
P
K
Y
L
F
---
P
E
D
P
S
Y
S
S
T
M
I
D
---------------------------------------------------------
66
Blastp_CBE
52.44
48%
12
- C1 -
-
5A6N
1
DAPK3_HUMAN
B:
[10-270]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
LSSS
R
R
-------
G
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
-----
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
T
I
-----
A
Q
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
214
Blastp_CBE
52.22
32%
-17
- C1 -
-
2Y7J
1
PHKG2_HUMAN
B:
[102-365]
-----------------------------------------
I
G
R
G
V
S
S
---
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
-----------
I
M
E
VTA---
S
P
-----
E
----
Q
L
-------
E
E
V
R
---
E
-
A
---
T
R
R
E
T
---
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
----
L
S
E
K
E
T
R
S
---
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
--
D
D
N
M
---
Q
----
I
R
L
S
D
F
G
F
S
C
H
--
L
-
E
P
G
E
K
L
R
E
-
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
------
K
CSMDET
H
P
G
Y
G
K
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
-
H
R
-
R
Q
--
I
L
M
L
R
M
-
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
-
E
A
R
-----
L
T
A
-----
E
Q
A
---
L
Q
-
H
P
F
F
-
E
R
--------------------------------------------------------------------------------
200
Blastp_CBE
52.15
34%
1
- C1 -
-
1QL6
1
PHKG1_RABIT
A:
[25-291]
-----------------------------------------
L
G
R
G
V
S
S
---
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
-----------
I
I
D
------
V
T
-----
G
----
G
G
SFSAEEV
Q
E
L
R
---
E
-
A
---
T
L
K
E
V
---
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
T
----
L
S
E
K
E
T
R
K
---
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
--
D
D
D
M
---
N
----
I
K
L
T
D
F
G
F
S
C
Q
--
L
-
D
P
G
E
K
L
R
S
-
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
ECSMND
N
------
H
P
G
Y
G
K
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
-
H
R
-
K
Q
--
M
L
M
L
R
M
-
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
-
Q
K
R
-----
Y
T
A
-----
E
E
A
---
L
A
-
H
P
F
F
-
Q
Q
Y
V
------------------------------------------------------------------------------
279
Blastp_CBE
52.13
33%
-25
- C1 -
-
4CFH
1
AAPK1_RAT
A:
[35-367]
---------------------------------
Y
I
L
-
G
D
T
-
L
G
V
G
T
F
G
---
K
V
K
V
G
K
H
E
L
T
G
H
K
V
A
V
K
-----------
I
L
N
------
R
Q
-----
K
I---
R
S
-------
L
D
V
V
---
G
-
K
---
I
R
R
E
I
---
Q
N
L
K
L
F
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
N
--
G
R
--
L
D
E
K
E
S
R
R
---
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
--
D
A
H
M
---
N
----
A
K
I
A
D
F
G
L
S
N
M
--
M
-
S
D
G
E
F
L
R
S
-
C
--
G
S
P
N
Y
A
A
P
E
V
I
------
S
------
G
R
L
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
--
D
D
-
D
H
--
V
P
T
L
F
K
-
K
I
C
D
G
I
F
Y
T
P
Q
Y
L
N
P
S
---
V
I
S
L
L
K
H
M
L
Q
V
D
P
-
M
K
R
-----
A
T
I
-----
K
D
I
---
R
E
-
H
E
W
F
-
K
Q
-
D
L
P
K
Y
L
F
---
P
E
D
P
S
Y
S
S
T
M
I
D
---------------------------------------------------------
190
Blastp_CBE
52.04
34%
-32
- C1 -
-
5DVR
1
?
A:
[75-461]
-----------------------------------------
L
G
K
G
S
F
G
---
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
-----------
V
I
S
------
K
-----------
V
K
-------
Q
K
T
D
---
K
-
E
S--
L
L
R
E
V
---
Q
L
L
K
Q
L
D
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
R
--
F
S
E
V
D
A
A
R
---
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
E
S
K
S
K
D
A
N
----
I
R
I
I
D
F
G
L
S
T
H
--
F
-
E
A
-
K
K
M
K
D
-
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
------
H
GT----
Y
D
E
---
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
-
G
A
-
N
E
--
Y
D
I
L
K
K
-
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
S
A
-----
R
D
A
---
L
D
-
H
E
W
I
-
Q
T
Y
T
K
E
Q
I
--------------------------------------------------------------------------
191
Blastp_CBE
51.86
34%
3
- C1 -
-
2PHK
2
PHKG1_RABIT
A:
[12-277]
-----------------------------------------
L
G
R
G
V
S
S
---
V
V
R
R
C
I
H
K
P
T
C
K
E
Y
A
V
K
-----------
I
I
D
------
V
T
-----
G
----
G
G
SFSAEEV
Q
E
L
R
---
E
-
A
---
T
L
K
E
V
---
D
I
L
R
K
V
S
G
H
P
N
I
I
Q
L
K
D
T
Y
E
T
N
T
F
F
F
L
V
F
D
L
M
K
K
G
E
L
F
D
Y
L
T
E
K
V
T
----
L
S
E
K
E
T
R
K
---
I
M
R
A
L
L
E
V
I
C
A
L
H
-
K
L
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
--
D
D
D
M
---
N
----
I
K
L
T
D
F
G
F
S
C
Q
--
L
-
D
P
G
E
K
L
R
E
-
V
C
-
G
T
P
S
Y
L
A
P
E
I
I
ECSMND
N
------
H
P
G
Y
G
K
E
-
V
D
M
W
S
T
G
V
I
M
Y
T
L
L
A
G
S
P
P
F
W
-
H
R
-
K
Q
--
M
L
M
L
R
M
-
I
M
S
G
N
Y
Q
F
G
S
P
E
W
D
D
Y
S
D
T
V
K
D
L
V
S
R
F
L
V
V
Q
P
-
Q
K
R
-----
Y
T
A
-----
E
E
A
---
L
A
-
H
P
F
F
-
Q
Q
Y
-------------------------------------------------------------------------------
274
Blastp_CBE
51.53
31%
-36
- C1 -
-
3PFQ
1
KPCB_RAT
A:
[292-609]
----------------------
M
--
K
L
T
D
F
N
F
L
M
V
L
------
G
K
G
S
F
G
---
K
V
M
L
S
E
R
K
G
T
D
E
L
Y
A
V
K
-----------
I
L
K
------
K
D
-----
V
----
V
I
-------
Q
D
D
D
---
V
-
E
C--
T
M
V
E
K
---
R
V
L
A
L
P
G
K
P
P
F
L
T
Q
L
H
S
C
F
Q
T
M
D
R
L
Y
F
V
M
E
Y
V
N
G
G
D
L
M
Y
H
I
--
Q
Q
V
G
R
--
F
K
E
P
H
A
V
F
---
Y
A
A
E
I
A
I
G
L
F
F
L
Q
-
S
K
G
I
I
Y
R
D
L
K
L
D
N
V
-
M
L
--
D
S
---
E
G
H
----
I
K
I
A
D
F
G
M
C
K
E
--
N
-
I
W
D
G
V
T
T
K
-
F
C
-
G
T
P
D
Y
I
A
P
E
I
I
------
A
------
Y
Q
P
Y
G
K
S
-
V
D
W
W
A
F
G
V
L
L
Y
E
M
L
A
G
Q
A
P
F
E
-
G
E
-
D
E
--
D
E
L
F
Q
S
-
I
M
E
H
N
V
A
Y
P
K
----
S
M
S
K
E
A
V
A
I
C
K
G
L
M
T
K
H
P
-
G
K
R
LGCG-
P
E
G
-----
E
R
D
---
I
K
E
H
A
F
F
-
R
Y
I
D
W
E
K
L
--------------------------------------------------------------------------
172
Blastp_CBE
51.27
34%
-32
- C1 -
-
3I7B
4
?
A:
[34-296]
-----------------------------------------
L
G
K
G
S
F
G
---
E
V
I
L
C
K
D
K
I
T
G
Q
E
C
A
V
K
-----------
V
I
S
------
K
R
-----
Q
----
V
K
-------
Q
K
T
D
---
K
-
E
S--
L
L
R
E
V
---
Q
L
L
K
Q
L
D
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
G
Y
F
Y
L
V
G
E
V
Y
T
G
G
E
L
F
D
E
I
I
S
R
--
K
R
--
F
S
E
V
D
A
A
R
---
I
I
R
Q
V
L
S
G
I
T
Y
M
H
-
K
N
K
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
E
S
K
S
K
D
A
N
----
I
R
I
I
D
F
G
L
S
T
H
--
F
-
E
A
S
K
K
M
K
D
-
K
I
-
G
T
A
Y
Y
I
A
P
E
V
L
------
H
GT----
Y
D
E
---
K
-
C
D
V
W
S
T
G
V
I
L
Y
I
L
L
S
G
C
P
P
F
N
-
G
A
-
N
E
--
Y
D
I
L
K
K
-
V
E
K
G
K
Y
T
F
E
L
P
Q
W
K
K
V
S
E
S
A
K
D
L
I
R
K
M
L
T
Y
V
P
-
S
M
R
-----
I
S
A
-----
R
D
A
---
L
D
-
H
E
W
I
-
Q
T
Y
T
K
E
Q
I
--------------------------------------------------------------------------
205
Blastp_CBE
51.21
33%
-16
- C1 -
-
3Q5I
1
?
A:
[42-310]
--------------------------------------
R
K
-
L
G
S
--
Y
G
---
E
V
L
L
C
K
E
K
N
G
H
S
E
K
A
I
K
-----------
V
I
K
------
K
------------------------KFH
E
-
E
---
I
Y
N
E
I
---
S
L
L
K
-
S
L
D
H
P
N
I
I
K
L
F
D
V
F
E
D
K
K
Y
F
Y
L
V
T
E
F
Y
E
G
G
E
L
F
E
Q
I
I
N
R
--
H
K
--
F
D
E
C
D
A
A
N
---
I
M
K
Q
I
L
S
G
I
C
Y
L
H
-
K
H
N
I
V
H
R
D
I
K
P
E
N
I
-
L
L
--
E
N
K
N
S
L
L
N
----
I
K
I
V
D
F
G
L
S
S
F
--
F
-
S
K
D
Y
K
L
R
D
-
R
L
-
G
T
A
Y
Y
I
A
P
E
V
L
------
K
-------
K
K
Y
N
E
K
-
C
D
V
W
S
C
G
V
I
M
Y
I
L
L
C
G
Y
P
P
F
G
-
G
Q
-
N
D
--
Q
D
I
I
K
K
-
V
E
K
G
K
Y
Y
F
D
F
N
D
W
K
N
I
S
D
E
A
K
E
L
I
K
L
M
L
T
Y
D
Y
-
N
K
R
-----
C
T
A
-----
E
E
A
---
L
N
-
S
R
W
I
-
K
K
Y
-------------------------------------------------------------------------------
146
Blastp_CBE
51.02
34%
11
- C1 -
-
3LIJ
1
?
A:
[18-303]
------------
G
D
L
Q
A
T
P
G
M
F
I
TS
K
K
G
H
L
S
E
M
Y
Q
R
V
-
K
K
-
L
G
S
---
G
---
E
V
L
L
C
R
D
K
V
T
H
V
E
R
A
I
K
-----------
I
I
R
------
K
---------------------
S
S
N
---
S
-
K
---
L
L
E
E
V
---
A
V
L
K
L
L
D
H
-
P
N
I
M
K
L
Y
D
F
F
E
D
K
R
N
Y
Y
L
V
M
E
C
Y
K
G
G
E
L
F
D
E
I
I
H
R
M
K
----
F
N
E
V
D
A
A
V
---
I
I
K
Q
V
L
S
G
V
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
E
S
K
E
K
D
A
L
----
I
K
I
V
D
F
G
L
S
A
V
--
F
-
E
N
Q
K
K
M
K
E
-
R
L
-
G
T
A
Y
Y
I
A
P
E
V
L
RK----
K
------
Y
D
E
---
K
-
C
D
V
W
S
I
G
V
I
L
F
I
L
L
A
G
Y
P
P
F
G
-
G
Q
-
T
D
--
Q
E
I
L
R
K
-
V
E
K
G
K
Y
T
F
D
S
P
E
W
K
N
V
S
E
G
A
K
D
L
I
K
Q
M
L
Q
F
D
S
-
Q
R
R
-----
I
S
A
-----
Q
Q
A
---
L
E
-
H
P
W
I
-
K
E
--------------------------------------------------------------------------------
255
Blastp_CBE
50.94
32%
-80
- C1 -
-
2CN8
1
CHK2_HUMAN
A:
[18-301]
---------------------------------
Y
I
M
-
S
K
T
-
L
G
S
-------
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
I
S
------
K
-----------------------------
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
---
T
S
L
M
R
T
-
L
C
---
P
T
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
------
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
-----------------------------------------------------------------
259
Blastp_CBE
50.78
32%
-46
- C1 -
-
5JZJ
1
B:
[40-295]
------------------------------------
V
G
R
T
-
I
G
D
G
N
F
A
---
V
V
K
E
C
V
E
R
S
T
A
R
E
Y
A
L
K
-----------
I
I
K
------
K
S
-----
K
---------------
C
R
---
G
-
K
EHM
I
Q
N
E
V
---
S
I
L
R
R
V
K
H
-
P
N
I
V
L
L
I
E
E
M
D
V
P
T
E
L
Y
L
V
M
E
L
V
K
G
G
D
L
F
D
A
I
T
S
--
T
N
K
--
Y
T
E
R
D
A
S
G
---
M
L
Y
N
L
A
S
A
I
K
Y
L
H
-
S
L
N
I
V
H
R
D
I
K
P
E
N
L
-
L
-----
V
Y
E
H
Q
D
GSKS
L
K
L
G
D
F
G
L
A
T
I
--
V
-
D
G
P
--
L
Y
T
-
V
C
-
G
T
P
T
Y
V
A
P
E
I
I
------
A
------
E
T
G
Y
G
L
K
-
V
D
I
W
A
A
G
V
I
T
Y
I
L
L
C
G
F
P
P
F
R
---------
E
V
L
F
D
Q
I
L
M
G
Q
V
D
F
P
S
P
Y
W
D
N
V
S
D
S
A
K
E
L
I
T
M
M
L
L
V
D
V
-
D
Q
R
-----
F
S
A
-----
V
Q
V
---
L
E
-
H
P
W
V
-----------------------------------------------------------------------------------
213
Blastp_CBE
50.74
32%
-16
- C1 -
-
2Y7J
1
PHKG2_HUMAN
C:
[102-365]
-----------------------------------------
I
G
R
G
V
S
S
---
V
V
R
R
C
V
H
R
A
T
G
H
E
F
A
V
K
-----------
I
M
E
VTAERL
S
P
-----
E
----
Q
L
-------
E
E
V
R
---
E
-
A
---
T
R
R
E
T
---
H
I
L
R
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
L
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
K
V
A
----
L
S
E
K
E
T
R
S
---
I
M
R
S
L
L
E
A
V
S
F
L
H
-
A
N
N
I
V
H
R
D
L
K
P
E
N
I
-
L
L
--
D
D
N
M
---
Q
----
I
R
L
S
D
F
G
F
S
C
H
--
L
-
E
P
G
E
K
L
R
E
-
L
C
-
G
T
P
G
Y
L
A
P
E
I
L
------
K
CSMDET
H
P
G
Y
G
K
E
-
V
D
L
W
A
C
G
V
I
L
F
T
L
L
A
G
S
P
P
F
W
-
H
R
-
R
Q
--
I
L
M
L
R
M
-
I
M
E
G
Q
Y
Q
F
S
S
P
E
W
D
D
R
S
S
T
V
K
D
L
I
S
R
L
L
Q
V
D
P
-
E
A
R
-----
L
T
A
-----
E
Q
A
---
L
Q
-
H
P
F
F
-
E
R
--------------------------------------------------------------------------------
203
Blastp_CBE
50.69
36%
-43
- C1 -
-
3HZT
9
?
A:
[10-295]
--------------------------------------
K
K
-
L
G
S
G
A
Y
G
---
E
V
L
L
C
K
D
K
L
T
G
A
E
R
A
I
K
-----------
I
I
K
------
K
S
-----
S
----
V
T
-------
T
T
S
N
---
S
G
A
---
L
L
D
E
V
---
A
V
L
K
Q
L
D
H
-
P
N
I
M
K
L
Y
E
F
F
E
D
K
R
N
Y
Y
L
V
M
E
V
Y
R
G
G
E
L
F
D
E
I
I
--
L
R
Q
K
--
F
S
E
V
D
A
A
V
---
I
M
K
Q
V
L
S
G
T
T
Y
L
H
-
K
H
N
I
V
H
R
D
L
K
P
E
N
L
-
L
L
--
E
S
K
S
R
D
A
L
----
I
K
I
V
D
F
G
L
S
A
H
--
F
-
E
V
----------
G
T
A
Y
Y
I
A
P
E
V
L
RK----
K
------
Y
D
E
---
K
-
C
D
V
W
S
C
G
V
I
L
Y
I
L
L
C
G
Y
P
P
F
G
-
G
Q
-
T
D
--
Q
E
I
L
K
R
-
V
E
K
G
K
F
S
F
D
P
P
D
W
T
Q
V
S
D
E
A
K
Q
L
V
K
L
M
L
T
Y
E
P
-
S
K
R
-----
I
S
A
-----
E
E
A
---
L
N
-
H
P
W
I
-----------------------------------------------------------------------------------
346
Blastp_CBE
49.94
31%
-97
- C1 -
-
6GR9
1
AURKC_HUMAN
A:
[15-263]
-------------------------------------
G
R
P
-
L
G
K
G
K
F
G
---
N
V
Y
L
A
R
L
K
E
S
H
F
I
V
A
L
K
-----------
V
L
F
------
K
S
-----
Q
----
I
E
-------
K
E
G
L
---
E
-
H
---
Q
L
R
R
E
---
I
E
I
Q
A
H
L
Q
H
P
N
I
L
R
L
Y
N
Y
F
H
D
A
R
R
V
Y
L
I
L
E
Y
A
P
R
G
E
L
Y
K
E
L
--
Q
K
S
D
K
--
L
D
E
Q
R
T
A
T
---
I
I
E
E
L
A
D
A
L
T
Y
C
H
-
D
K
K
V
I
H
R
D
I
K
P
E
N
L
-
L
L
--
G
F
---
R
G
E
----
V
K
I
A
D
F
G
W
S
------
V
H
T
P
S
L
R
R
-
K
M
C
G
T
L
D
Y
L
P
P
E
M
I
------
E
------
G
R
T
Y
D
E
K
-
V
D
L
W
C
I
G
V
L
C
Y
E
L
L
V
G
Y
P
P
F
E
-
S
A
-
S
H
--
S
E
T
Y
R
R
-
I
L
K
V
D
V
R
F
P
----
L
S
M
P
L
G
A
R
D
L
I
S
R
L
L
R
Y
Q
P
L
E
R
L
-----
P
L
A
-----
Q
I
----
L
K
-
H
P
W
V
-
Q
---------------------------------------------------------------------------------
249
Blastp_CBE
49.85
32%
-88
- C1 -
-
2XM8
1
CHK2_HUMAN
A:
[18-301]
---------------------------------
Y
I
M
-
S
K
T
-
L
-----
G
---
E
V
K
L
A
F
E
R
K
T
C
K
K
V
A
I
K
-----------
I
--------------------------------------
N
---
V
E
T
E
I
---
E
I
L
K
K
L
N
H
-
P
C
I
I
K
I
K
N
F
F
-
D
A
E
D
Y
Y
I
V
L
E
L
M
E
G
G
E
L
F
D
K
V
V
G
N
--
K
R
--
L
K
E
A
T
C
K
L
---
Y
F
Y
Q
M
L
L
A
V
Q
Y
L
H
-
E
N
G
I
I
H
R
D
L
K
P
E
N
V
-
L
L
--
S
S
Q
E
E
D
C
L
----
I
K
I
T
D
F
G
H
S
K
I
--
L
---
T
S
L
M
R
T
-
L
C
-
G
---
Y
L
A
P
E
V
L
VSV---
G
------
T
A
G
Y
N
R
A
-
V
D
C
W
S
L
G
V
I
L
F
I
C
L
S
G
Y
P
P
F
S
-
E
H
-
R
T
--
Q
V
S
L
K
D
Q
I
T
S
G
K
Y
N
F
I
P
E
V
W
A
E
V
S
E
K
A
L
D
L
V
K
K
L
L
V
V
D
P
-
K
A
R
-----
F
T
T
-----
E
E
A
---
L
R
-
H
P
W
L
-
Q
D
E
D
M
K
R
K
F
Q
DLL
S
E
E
N
-----------------------------------------------------------------
269
Blastp_CBE
49.63
31%
-89
- C1 -
-
5O1S
2
A:
[50-307]
--------------------------------------
E
D
-
I
-----
S
---
V
C
K
R
C
I
H
K
A
T
N
M
E
F
A
V
K
-----------
I
I
D
------
K
S
-----
K
----
R
-----------------
D
---
P
T
E
E
I
---
E
I
L
L
R
Y
G
Q
H
P
N
I
I
T
L
K
D
V
Y
D
D
G
K
Y
V
Y
V
V
T
E
L
M
K
G
G
E
L
L
D
K
I
L
R
Q
--
K
F
--
F
S
E
R
E
A
S
A
---
V
L
F
T
I
T
K
T
V
E
Y
L
H
-
A
Q
G
V
V
H
R
D
L
K
P
S
N
I
-
L
Y
VD
E
S
G
N
P
-
E
S
----
I
R
I
C
D
F
G
F
A
K
Q
--
L
R
A
E
N
G
L
L
M
T
-
P
C
----
N
F
V
A
P
E
V
L
------
E
------
R
Q
G
Y
D
A
A
-
C
D
I
W
S
L
G
V
L
L
Y
T
M
L
T
G
Y
T
P
F
A
N
G
P
-
D
D
TP
E
E
I
L
A
R
-
I
G
S
G
K
F
S
L
S
G
G
Y
W
N
S
V
S
D
T
A
K
D
L
V
S
K
M
L
H
V
D
P
-
H
Q
R
-----
L
T
A
-----
A
L
V
---
L
R
-
H
P
W
I
-
V
H
W
D
------------------------------------------------------------------------------
333
Blastp_CBE
47.50
32%
-129
- C1 -
-
3A61
1
KS6B1_HUMAN
A:
[29-266]
------------------------------------------
G
Y
G
K
V
F
---
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
-----------
V
L
------------------------------------------
K
A
E
R
---
N
I
L
E
E
V
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
--
E
R
E
G
I
--
F
M
E
D
T
A
C
F
---
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
-
M
L
--
N
H
---
Q
G
H
----
V
K
L
T
D
F
G
--------------------
G
T
I
E
Y
M
A
P
E
I
L
------
M
------
R
S
G
H
N
R
A
-
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
-
G
E
-
N
R
--
K
K
T
I
D
K
-
I
L
K
C
K
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
-
A
S
R
-----
L
G
A
-----------------------------------------------------------------------------------------------------
330
Blastp_CBE
46.95
33%
-28
- C1 -
-
5F9E
1
B:
[16-294]
----------------------
L
--
K
I
E
D
F
E
-----
L
H
K
M
-
L
G
K
G
S
F
G
---
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
-----------
A
L
K
------
K
D
-----
V
----
V
L
-------
M
D
D
D
---
V
-
E
C--
T
M
V
E
K
---
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
-----
Q
S
--
C
H
K
F
D
L
S
R
ATF
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
-
L
L
--
D
K
D
---
G
H
----
I
K
I
A
D
F
G
M
C
K
E
NM
L
-
G
D
A
-
K
T
N
E
-
F
C
-
G
T
P
D
Y
I
A
P
E
I
L
------
L
------
G
Q
K
Y
N
H
S
-
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
-
G
Q
-
D
E
--
E
E
L
F
H
S
-
I
R
M
D
N
P
F
Y
P
----
R
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
-
E
K
R
-------------------------------------------------------------------------------------------------------------
319
Blastp_CBE
46.90
32%
-116
- C1 -
-
3A62
1
KS6B1_HUMAN
A:
[29-266]
------------------------------------------
G
Y
G
K
V
F
---
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
-----------
V
L
K
-----------------------------------------
K
A
E
R
---
N
I
L
E
E
V
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
--
E
R
E
G
I
--
F
M
E
D
T
A
C
F
---
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
-
M
L
--
N
H
---
Q
G
H
----
V
K
L
T
D
F
G
L
C
K
E
-------------
F
C
-
G
T
I
E
Y
M
A
P
E
I
L
------
M
------
R
S
G
H
N
R
A
-
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
-
G
E
-
N
R
--
K
K
T
I
D
K
-
I
L
K
C
K
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
-
A
S
R
-----
L
G
A
-----------------------------------------------------------------------------------------------------
289
Blastp_CBE
46.81
32%
-48
- C1 -
-
6BX6
1
AAPK2_HUMAN
A:
[13-274]
---------------------------------
Y
V
L
-
G
D
T
-
L
G
V
G
T
F
G
---
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
-----------
I
L
N
------
R
Q
-----
K
I---
R
S
-------
L
D
V
V
---
G
-
K
---
I
K
R
E
I
---
Q
N
L
K
L
F
R
H
-
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
H
--
G
R
--
V
E
E
M
E
A
R
R
---
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
-
R
H
M
V
V
H
R
D
L
K
P
E
N
V
-
L
L
--
D
A
H
M
---
N
----
A
K
I
A
D
F
G
L
S
---------------------
N
Y
A
A
P
E
------------------
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
-
D
E
-
H
V
--
P
T
L
F
K
K
-
I
R
G
G
V
F
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
----
D
P
-
L
K
R
-----
A
T
I
-----
K
D
I
---
R
E
-
H
E
W
F
-
K
Q
-
D
L
P
S
Y
L
F
------------------------------------------------------------------------
343
Blastp_CBE
46.76
32%
-23
- C1 -
-
4RA5
3
KPCT_HUMAN
A:
[2-248]
----------------------
L
--
K
I
E
D
F
E
-----
L
H
K
M
-
L
G
K
G
S
F
G
---
K
V
F
L
A
E
F
K
K
T
N
Q
F
F
A
I
K
-----------
A
L
K
------
K
D
-----
V
----
V
L
-------
M
D
D
D
---
V
-
E
C--
T
M
V
E
K
---
R
V
L
S
L
A
W
E
H
P
F
L
T
H
M
F
C
T
F
Q
T
K
E
N
L
F
F
V
M
E
Y
L
N
G
G
D
L
M
Y
H
I
-----
Q
S
--
C
H
K
F
D
L
S
R
ATF
Y
A
A
E
I
I
L
G
L
Q
F
L
H
-
S
K
G
I
V
Y
R
D
L
K
L
D
N
I
-
L
L
--
D
K
D
---
G
H
----
I
K
I
A
D
F
G
M
C
K
E
NM
L
-
G
D
A
-
K
T
N
E
-
F
C
-
G
T
P
D
Y
I
A
P
E
I
L
------
L
------
G
Q
K
Y
N
H
S
-
V
D
W
W
S
F
G
V
L
L
Y
E
M
L
I
G
Q
S
P
F
H
-
G
Q
-
D
E
--
E
E
L
F
H
S
-
I
R
M
D
N
P
F
Y
P
R
----
W
L
E
K
E
A
K
D
L
L
V
K
L
F
V
R
E
P
-
E
K
R
-------------------------------------------------------------------------------------------------------------
368
Blastp_CBE
44.18
31%
-30
- C1 -
-
3CQU
1
AKT1_HUMAN
A:
[16-269]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
378
Blastp_CBE
43.60
31%
-31
- C1 -
-
3QKK
1
AKT1_HUMAN
A:
[15-260]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
379
Blastp_CBE
43.14
31%
-29
- C1 -
-
3OW4
1
AKT1_HUMAN
B:
[15-269]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
367
Blastp_CBE
43.06
31%
-32
- C1 -
-
3CQW
1
AKT1_HUMAN
A:
[16-269]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
387
Blastp_CBE
43.05
31%
-47
- C1 -
-
3L9M
1
KAPCA_HUMAN
A:
[48-280]
--------------------------------------
K
T
-
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
-----------
I
L
D
------
K
Q
-----
K
----
V
V
-------
K
L
K
Q
---
I
-
E
H--
T
L
N
E
K
---
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
---
S
E
P
H
A
R
F
---
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
--
D
Q
---
Q
G
Y
----
I
K
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
L
----
C
-
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
K
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
-
A
D
-
Q
P
--
I
Q
I
Y
E
K
-
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-------------------------------------------------------------------------------------------------------------------
394
Blastp_CBE
43.01
31%
-42
- C1 -
-
6C0U
4
KAPCA_HUMAN
A:
[51-283]
--------------------------------------
K
T
-
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
-----------
I
L
D
------
K
Q
-----
K
----
V
V
-------
K
L
K
Q
---
I
-
E
H--
T
L
N
E
K
---
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
---
S
E
P
H
A
R
F
---
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
--
D
Q
---
Q
G
Y
----
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
L
----
C
-
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
K
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
-
A
D
-
Q
P
--
I
Q
I
Y
E
K
-
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-------------------------------------------------------------------------------------------------------------------
373
Blastp_CBE
43.01
31%
-27
- C1 -
-
4EKL
1
AKT1_HUMAN
A:
[15-257]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
366
Blastp_CBE
42.24
31%
-29
- C1 -
-
3MV5
1
AKT1_HUMAN
A:
[16-271]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
364
Blastp_CBE
42.13
31%
-31
- C1 -
-
4GV1
5
AKT1_HUMAN
A:
[14-256]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
375
Blastp_CBE
42.07
31%
-37
- C1 -
-
4EKK
1
AKT1_HUMAN
A:
[15-267]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
73
Blastp_CBE
42.03
49%
4
- C1 -
-
2J90
2
DAPK3_HUMAN
A:
[31-291]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
K
G
T
G
K
E
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
LSS-
R
R
-------
G
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
S
--
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
A
-----------
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
I
A
-----
Q
-
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
389
Blastp_CBE
41.95
31%
-44
- C1 -
-
3QAL
1
KAPCA_MOUSE
E:
[47-279]
--------------------------------------
K
T
-
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
-----------
I
L
D
------
K
Q
-----
K
----
V
V
-------
K
L
K
Q
---
I
-
E
H--
T
L
N
E
K
---
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
---
S
E
P
H
A
R
F
---
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
--
D
Q
---
Q
G
Y
----
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
L
----
C
-
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
K
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
-
A
D
-
Q
P
--
I
Q
I
Y
E
K
-
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-------------------------------------------------------------------------------------------------------------------
380
Blastp_CBE
41.93
31%
-24
- C1 -
-
3OW4
1
AKT1_HUMAN
A:
[15-269]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
386
Blastp_CBE
41.92
31%
-46
- C1 -
-
3L9M
1
KAPCA_HUMAN
B:
[48-280]
--------------------------------------
K
T
-
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
-----------
I
L
D
------
K
Q
-----
K
----
V
V
-------
K
L
K
Q
---
I
-
E
H--
T
L
N
E
K
---
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
---
S
E
P
H
A
R
F
---
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
--
D
Q
---
Q
G
Y
----
I
K
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
L
----
C
-
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
K
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
-
A
D
-
Q
P
--
I
Q
I
Y
E
K
-
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-------------------------------------------------------------------------------------------------------------------
374
Blastp_CBE
41.77
31%
-33
- C1 -
-
4EKK
1
AKT1_HUMAN
B:
[15-267]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
382
Blastp_CBE
41.76
31%
-26
- C1 -
-
3OCB
1
AKT1_HUMAN
A:
[15-271]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
365
Blastp_CBE
41.76
31%
-27
- C1 -
-
3MVH
1
AKT1_HUMAN
A:
[16-273]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
320
Blastp_CBE
41.76
31%
-10
- C1 -
-
2WTW
1
AURKA_HUMAN
A:
[18-265]
-------------------------------------
G
R
P
-
L
G
K
G
K
F
G
---
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
-----------
V
L
F
------
K
------------
A
-------
Q
L
E
K
---
A
-
G
---
V
E
H
Q
L
RRE
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
----
E
L
Q
K
L
SK
F
D
E
Q
R
T
A
T
---
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
-
L
L
--
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
S
------
V
H
A
P
S
-----
C
-
G
T
L
D
Y
L
P
P
E
M
I
------
E
------
G
R
M
H
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
-
A
N
-
T
Y
--
Q
E
T
Y
K
R
-
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
-
S
Q
R
-----
P
M
L
-----
R
E
V
---
L
E
-
H
P
W
I
-----------------------------------------------------------------------------------
388
Blastp_CBE
41.64
31%
-41
- C1 -
-
3FHI
1
KAPCA_MOUSE
A:
[47-279]
--------------------------------------
K
T
-
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
S
G
N
H
Y
A
M
K
-----------
I
L
D
------
K
Q
-----
K
----
V
V
-------
K
L
K
Q
---
I
-
E
H--
T
L
N
E
K
---
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
V
A
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
---
S
E
P
H
A
R
F
---
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
L
I
--
D
Q
---
Q
G
Y
----
I
Q
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
L
----
A
-
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
K
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
-
A
D
-
Q
P
--
I
Q
I
Y
E
K
-
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-------------------------------------------------------------------------------------------------------------------
381
Blastp_CBE
41.54
31%
-28
- C1 -
-
3OCB
1
AKT1_HUMAN
B:
[15-267]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
N
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
R
----
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
363
Blastp_CBE
41.18
31%
-28
- C1 -
-
6CCY
1
AKT1_HUMAN
A:
[14-268]
--------------------------------------
K
L
-
L
G
K
G
T
F
G
---
K
V
I
L
V
K
E
K
A
T
G
R
Y
Y
A
M
K
-----------
I
L
K
------
K
E
-----
V
I---
V
A
-------
K
D
E
V
---
A
-
H
---
T
L
T
E
S
---
R
V
L
Q
N
S
R
H
-
P
F
L
T
A
L
K
Y
S
F
Q
T
H
D
R
L
C
F
V
M
E
Y
A
N
G
G
E
L
F
F
H
L
S
R
E
--
R
V
--
F
S
E
D
R
A
R
F
---
Y
G
A
E
I
V
S
A
L
D
Y
L
H
S
E
K
N
V
V
Y
R
D
L
K
L
E
N
L
-
M
L
--
D
K
D
---
G
H
----
I
K
I
T
D
F
G
L
C
K
E
--
G
-
I
K
D
G
A
T
M
K
-
F
C
-
G
T
P
E
Y
L
A
P
E
V
L
------
E
------
D
N
D
Y
G
R
A
-
V
D
W
W
G
L
G
V
V
M
Y
E
M
M
C
G
R
L
P
F
Y
-
N
Q
-
D
H
--
E
K
L
F
E
L
-
I
L
M
E
E
I
R
F
P
----
R
T
L
G
P
E
A
K
S
L
L
S
G
L
L
K
K
D
P
-
K
Q
R
-------------------------------------------------------------------------------------------------------------
290
Blastp_CBE
41.01
31%
1
- C1 -
-
6G78
1
KS6A6_HUMAN
B:
[35-300]
--------------------------------------
K
V
-
L
G
Q
G
S
F
G
KVF
L
V
R
K
K
T
G
P
D
A
G
Q
L
Y
A
M
K
-----------
V
L
K
------
K
A
-----
S
----
L
K
-------
V
R
D
------------------
D
I
L
-
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
V
--
L
--
F
T
E
E
D
V
K
F
---
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
-
L
L
--
D
E
I
---
G
H
----
I
K
L
T
D
F
G
L
S
K
E
S-
V
-------------
G
T
V
E
Y
M
A
P
E
V
V
------
N
------
R
R
G
H
S
Q
S
-
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
-
G
K
-
D
R
--
N
E
T
M
N
M
-
I
L
K
A
K
L
G
M
P
Q
----
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
-
A
N
R
-----
L
G
S
-----
E
G
V
EEI
K
R
-
H
L
F
F
-
A
N
I
D
W
D
K
L
Y
K
---
R
E
-------------------------------------------------------------------
385
Blastp_CBE
40.89
31%
-49
- C1 -
-
3L9N
1
KAPCA_HUMAN
A:
[48-283]
--------------------------------------
K
T
-
L
G
T
G
S
F
G
---
R
V
M
L
V
K
H
K
E
T
G
N
H
Y
A
M
K
-----------
I
L
D
------
K
Q
-----
K
----
V
V
-------
K
L
K
Q
---
I
-
E
H--
T
L
N
E
K
---
R
I
L
Q
-
A
V
N
F
P
F
L
V
K
L
E
F
S
F
K
D
N
S
N
L
Y
M
V
M
E
Y
A
P
G
G
E
M
F
S
-
H
L
R
R
I
G
R
F
---
S
E
P
H
A
R
F
---
Y
A
A
Q
I
V
L
T
F
E
Y
L
H
-
S
L
D
L
I
Y
R
D
L
K
P
E
N
L
-
M
I
--
D
Q
---
Q
G
Y
----
I
K
V
T
D
F
G
F
A
K
R
--
V
-
K
G
R
T
W
L
----
C
-
G
T
P
E
Y
L
A
P
E
I
I
------
L
------
S
K
G
Y
N
K
A
-
V
D
W
W
A
L
G
V
L
I
Y
E
M
A
A
G
Y
P
P
F
F
-
A
D
-
Q
P
--
I
Q
I
Y
E
K
-
I
V
S
G
K
V
R
F
P
S
H
F
S
S
D
L
K
D
L
L
R
N
L
L
Q
V
D
L
T
K
-------------------------------------------------------------------------------------------------------------------
338
Blastp_CBE
40.89
32%
-118
- C1 -
-
4RLO
4
KS6B1_HUMAN
B:
[17-254]
------------------------------------------
G
Y
G
K
V
F
---
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
-----------
V
L
K
------
K
-----------------------------------------------
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
--
E
R
E
G
I
--
F
M
E
D
T
A
C
F
---
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
-
M
L
--
N
H
---
Q
G
H
----
V
K
L
T
D
F
G
L
C
K
E
--
S
-
I
------------
T
I
E
Y
M
A
P
E
I
L
------
M
------
R
S
G
H
N
R
A
-
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
-
G
E
-
N
R
--
K
K
T
I
D
K
-
I
L
K
C
K
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
-
A
S
R
-----
L
G
A
-----------------------------------------------------------------------------------------------------
72
Blastp_CBE
40.80
49%
7
- C1 -
-
2J90
3
DAPK3_HUMAN
B:
[31-291]
-------------------------------------
G
E
E
-
L
G
S
G
Q
F
A
---
I
V
R
K
C
R
Q
----
K
E
Y
A
A
K
-----------
F
I
K
------
K
R
-----
R
LSS-
R
R
-------
G
V
S
R
---
E
-
E
---
I
E
R
E
V
---
N
I
L
R
E
I
R
H
-
P
N
I
I
T
L
H
D
I
F
E
N
K
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
E
K
--
E
---
L
T
E
D
E
A
T
Q
---
F
L
K
Q
I
L
D
G
V
H
Y
L
H
-
S
K
R
I
A
H
F
D
L
K
P
E
N
I
M
L
L
--
D
K
N
V
P
N
P
R
----
I
K
L
I
D
F
G
I
A
H
K
--
I
-
E
A
G
N
E
F
K
N
-
I
F
-
G
T
P
E
F
V
A
P
E
I
V
------
N
------
Y
E
P
L
G
L
E
-
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
-
G
E
-
T
K
--
Q
E
T
L
T
N
-
I
S
A
V
N
Y
D
F
D
E
E
Y
F
S
N
T
S
E
L
A
K
D
F
I
R
R
L
L
V
K
D
P
-
K
R
R
-----
M
I
A
-----
Q
-
S
---
L
E
-
H
S
W
I
-
K
---------------------------------------------------------------------------------
293
Blastp_CBE
40.71
31%
-6
- C1 -
-
2Z7S
1
KS6A1_HUMAN
A:
[34-301]
--------------------------------------
K
V
-
L
G
Q
G
S
F
G
KVF
L
V
R
K
V
T
R
P
D
S
G
H
L
Y
A
M
K
-----------
V
L
K
-------------------------------------------------
I
L
A
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
--
M
--
F
T
E
E
D
V
K
F
---
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
-
L
L
--
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
------
N
------
R
Q
G
H
S
H
S
-
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
-
G
K
-
D
R
--
K
E
T
M
T
L
-
I
L
K
A
K
L
G
M
P
Q
----
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
-
A
N
R
LGSGP
D
G
A
-----
E
E
I
---
K
R
-
H
V
F
Y
-
S
T
I
D
W
N
K
L
Y
R
---
R
E
-------------------------------------------------------------------
327
Blastp_CBE
40.56
31%
-24
- C1 -
-
2XRU
1
AURKA_HUMAN
A:
[13-260]
-------------------------------------
G
R
P
-
L
G
K
G
K
F
G
---
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
-----------
V
L
F
------
K
------------
A
-------
Q
L
E
K
---
A
-
G
---
V
E
H
Q
L
RRE
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
----
E
L
Q
K
L
SK
F
D
E
Q
R
T
A
T
---
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
-
L
L
--
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
S
V
---------------
C
-
G
T
L
D
Y
L
P
P
E
M
I
------
E
------
G
R
M
H
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
-
A
N
-
T
Y
--
Q
E
T
Y
K
R
-
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
-
S
Q
R
-----
P
M
L
-----
R
E
V
---
L
E
-
H
P
W
I
-----------------------------------------------------------------------------------
341
Blastp_CBE
40.23
32%
-5
- C1 -
-
4L3J
1
KS6B1_HUMAN
A:
[30-267]
------------------------------------------
G
Y
G
K
V
F
---
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
-----------
V
L
K
------
K
A
MIV--
R
----
N
A
-------
K
D
T
----
A
-
H
---
T
K
A
E
R
---
N
I
L
E
E
V
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
--
E
R
E
G
I
--
F
M
E
D
T
A
C
F
---
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
-
M
L
--
N
H
---
Q
G
H
----
V
K
L
T
D
F
G
L
C
K
E
--
S
-
I
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
------
R
S
G
H
N
R
A
-
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
-
G
E
-
N
R
--
K
K
T
I
D
K
-
I
L
K
C
K
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
-
A
S
R
-----
L
G
A
-----------------------------------------------------------------------------------------------------
294
Blastp_CBE
40.20
31%
3
- C1 -
-
2Z7R
1
KS6A1_HUMAN
A:
[34-301]
--------------------------------------
K
V
-
L
G
Q
G
S
F
G
KVF
L
V
R
K
V
T
R
P
D
S
G
H
L
Y
A
M
K
-----------
V
L
K
------
K
A
-----
T
----
L
K
-------
V
---------------------
I
L
A
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
--
M
--
F
T
E
E
D
V
K
F
---
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
-
L
L
--
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
------
N
------
R
Q
G
H
S
H
S
-
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
-
G
K
-
D
R
--
K
E
T
M
T
L
-
I
L
K
A
K
L
G
M
P
Q
----
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
-
A
N
R
LGSGP
D
G
A
-----
E
E
I
---
K
R
-
H
V
F
Y
-
S
T
I
D
W
N
K
L
Y
R
---
R
E
-------------------------------------------------------------------
295
Blastp_CBE
39.89
31%
-7
- C1 -
-
2Z7Q
1
KS6A1_HUMAN
A:
[34-301]
--------------------------------------
K
V
-
L
G
Q
G
S
F
G
KVF
L
V
R
K
V
T
R
P
D
S
G
H
L
Y
A
M
K
-----------
V
L
--------------------------------------------------
I
L
A
D
V
-
N
H
P
F
V
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
--
M
--
F
T
E
E
D
V
K
F
---
Y
L
A
E
L
A
L
G
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
-
L
L
--
D
E
E
---
G
H
----
I
K
L
T
D
F
G
L
S
K
E
----------------
G
T
V
E
Y
M
A
P
E
V
V
------
N
------
R
Q
G
H
S
H
S
-
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
S
L
P
F
Q
-
G
K
-
D
R
--
K
E
T
M
T
L
-
I
L
K
A
K
L
G
M
P
Q
----
F
L
S
T
E
A
Q
S
L
L
R
A
L
F
K
R
N
P
-
A
N
R
LGSGP
D
G
A
-----
E
E
I
---
K
R
-
H
V
F
Y
-
S
T
I
D
W
N
K
L
Y
R
---
R
E
-------------------------------------------------------------------
291
Blastp_CBE
39.85
31%
5
- C1 -
-
6G78
1
KS6A6_HUMAN
A:
[35-300]
--------------------------------------
K
V
-
L
G
Q
G
S
F
G
KVF
L
V
R
K
K
T
G
P
D
A
G
Q
L
Y
A
M
K
-----------
V
L
K
------
K
A
-----
S
----
L
K
-------
V
R
D
------------------
D
I
L
-
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
V
F
T
R
L
S
K
E
V
--
L
--
F
T
E
E
D
V
K
F
---
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
Q
L
G
I
V
Y
R
D
L
K
P
E
N
I
-
L
L
--
D
E
I
---
G
H
----
I
K
L
T
D
F
G
L
S
K
E
S-
V
-
D
Q
----------
G
T
V
E
Y
M
A
P
E
V
V
------
N
------
R
R
G
H
S
Q
S
-
A
D
W
W
S
Y
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
-
G
K
-
D
R
--
N
E
T
M
N
M
-
I
L
K
A
K
L
G
M
P
Q
----
F
L
S
A
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
-
A
N
R
-----
L
G
S
-----
E
G
V
EEI
K
R
-
H
L
F
F
-
A
N
I
D
W
D
K
L
Y
K
---
R
E
-------------------------------------------------------------------
300
Blastp_CBE
39.79
31%
-23
- C1 -
-
3UBD
1
KS6A3_MOUSE
A:
[30-297]
--------------------------------------
K
V
-
L
G
Q
G
S
F
G
KVF
L
V
K
K
I
S
G
S
D
A
R
Q
L
Y
A
M
K
-----------
V
L
K
------
K
A
-----
T
----
L
K
-------
V
R
D
R
---
V
-------------
D
I
L
-
V
E
V
N
H
P
F
I
V
K
L
H
Y
A
F
Q
T
E
G
K
L
Y
L
I
L
D
F
L
R
G
G
D
L
F
T
R
L
S
K
E
V
--
M
--
F
T
E
E
D
V
K
F
---
Y
L
A
E
L
A
L
A
L
D
H
L
H
-
S
L
G
I
I
Y
R
D
L
K
P
E
N
I
-
L
L
--
D
E
---
E
G
H
----
I
K
L
T
D
F
G
L
S
K
-------
E
K
K
A
Y
S
-
F
C
-
G
T
V
E
Y
M
A
P
E
V
V
------
N
------
R
R
G
H
T
Q
S
-
A
D
W
W
S
F
G
V
L
M
F
E
M
L
T
G
T
L
P
F
Q
-
G
K
-
D
R
--
K
E
T
M
T
M
-
I
L
K
A
K
L
G
M
P
Q
----
F
L
S
P
E
A
Q
S
L
L
R
M
L
F
K
R
N
P
-
A
N
R
-----
L
G
A
GPDGV
E
E
I
---
K
R
-
H
S
F
F
-
S
T
I
D
W
N
K
L
Y
R
---
R
E
-------------------------------------------------------------------
340
Blastp_CBE
39.19
32%
-4
- C1 -
-
4L3L
1
KS6B1_HUMAN
A:
[30-267]
------------------------------------------
G
Y
G
K
V
F
---
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
-----------
V
L
K
------
K
A
MIV--
R
----
N
A
-------
K
D
T
----
A
-
H
---
T
K
A
E
R
---
N
I
L
E
E
V
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
--
E
R
E
G
I
--
F
M
E
D
T
A
C
F
---
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
-
M
L
--
N
H
---
Q
G
H
----
V
K
L
T
D
F
G
L
C
K
E
--
S
-
I
H
D
G
T
V
T
H
-
T
F
C
G
T
I
E
Y
M
A
P
E
I
L
------
M
------
R
S
G
H
N
R
A
-
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
-
G
E
-
N
R
--
K
K
T
I
D
K
-
I
L
K
C
K
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
-
A
S
R
-----
L
G
A
-----------------------------------------------------------------------------------------------------
334
Blastp_CBE
38.16
32%
-86
- C1 -
-
3A60
1
KS6B1_HUMAN
B:
[29-266]
------------------------------------------
G
Y
G
K
V
F
---
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
-----------
V
L
K
------
K
-----------------------------------------------
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
--
E
R
E
G
I
--
F
M
E
D
T
A
C
F
---
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
-
M
L
--
N
H
---
Q
G
H
----
V
K
L
T
D
F
G
L
C
K
E
--
S
------------C
G
T
I
E
Y
M
A
P
E
I
L
------
M
------
R
S
G
H
N
R
A
-
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
-
G
E
-
N
R
--
K
K
T
I
D
K
-
I
L
K
C
K
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
-
A
S
R
-----
L
G
A
-----------------------------------------------------------------------------------------------------
335
Blastp_CBE
38.05
32%
-42
- C1 -
-
3A60
1
KS6B1_HUMAN
A:
[29-266]
------------------------------------------
G
Y
G
K
V
F
---
Q
V
R
K
V
T
G
A
N
T
G
K
I
F
A
M
K
-----------
V
L
K
------
K
A
M--------------------------------
K
A
E
R
---
N
I
L
E
E
V
K
H
-
P
F
I
V
D
L
I
Y
A
F
Q
T
G
G
K
L
Y
L
I
L
E
Y
L
S
G
G
E
L
F
M
Q
L
--
E
R
E
G
I
--
F
M
E
D
T
A
C
F
---
Y
L
A
E
I
S
M
A
L
G
H
L
H
-
Q
K
G
I
I
Y
R
D
L
K
P
E
N
I
-
M
L
--
N
H
---
Q
G
H
----
V
K
L
T
D
F
G
L
C
K
E
-----------------
T
I
E
Y
M
A
P
E
I
L
------
M
------
R
S
G
H
N
R
A
-
V
D
W
W
S
L
G
A
L
M
Y
D
M
L
T
G
A
P
P
F
T
-
G
E
-
N
R
--
K
K
T
I
D
K
-
I
L
K
C
K
L
N
L
P
----
P
Y
L
T
Q
E
A
R
D
L
L
K
K
L
L
K
R
N
A
-
A
S
R
-----
L
G
A
-----------------------------------------------------------------------------------------------------
348
Blastp_CBE
37.89
31%
-16
- C1 -
-
2DWB
1
AURKA_HUMAN
A:
[18-265]
-------------------------------------
G
R
P
-
L
G
K
G
K
F
G
---
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
-----------
V
L
F
------
K
------------
A
-------
Q
L
E
K
---
A
-
G
---
V
E
H
Q
L
RRE
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
L
G
T
V
Y
R
----
E
L
Q
K
L
SK
F
D
E
Q
R
T
A
T
---
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
-
L
L
--
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
S
R
-T
L
C
-
G
T
L
D
Y
L
P
P
E
I
E
------
G
------
R
H
M
-
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
-
A
N
-
T
Y
--
Q
E
T
Y
K
R
-
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
-
S
Q
R
-----
P
L
R
-----
E
V
----
L
E
-
H
P
W
I
-----------------------------------------------------------------------------------
309
Blastp_CBE
34.97
31%
-16
- C1 -
-
2WTV
9
AURKA_HUMAN
B:
[18-265]
-------------------------------------
G
R
P
-
L
G
K
G
K
F
G
---
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
-----------
V
L
F
------
K
------------
A
-------
Q
L
E
K
---
A
-
G
---
V
E
H
Q
L
RRE
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
----
E
L
Q
K
L
SK
F
D
E
Q
R
T
A
T
---
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
-
L
L
--
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
S
R
R
--
L
-
G
T
L
D
Y
L
P
P
E
M
I
------
E
------
G
R
M
H
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
-
A
N
-
T
Y
--
Q
E
T
Y
K
R
-
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
-
S
Q
R
-----
P
M
L
-----
R
E
V
---
L
E
-
H
P
W
I
-----------------------------------------------------------------------------------
308
Blastp_CBE
34.50
31%
-14
- C1 -
-
2WTV
5
AURKA_HUMAN
C:
[18-265]
-------------------------------------
G
R
P
-
L
G
K
G
K
F
G
---
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
-----------
V
L
F
------
K
------------
A
-------
Q
L
E
K
---
A
-
G
---
V
E
H
Q
L
RRE
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
----
E
L
Q
K
L
SK
F
D
E
Q
R
T
A
T
---
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
-
L
L
--
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
S
R
R
--
L
-
G
T
L
D
Y
L
P
P
E
M
I
------
E
------
G
R
M
H
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
-
A
N
-
T
Y
--
Q
E
T
Y
K
R
-
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
-
S
Q
R
-----
P
M
L
-----
R
E
V
---
L
E
-
H
P
W
I
-----------------------------------------------------------------------------------
307
Blastp_CBE
33.06
31%
-6
- C1 -
-
2WTV
3
AURKA_HUMAN
D:
[18-265]
-------------------------------------
G
R
P
-
L
G
K
G
K
F
G
---
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
-----------
V
L
F
------
K
------------
A
-------
Q
L
E
K
---
A
-
G
---
V
E
H
Q
L
RRE
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
----
E
L
Q
K
L
SK
F
D
E
Q
R
T
A
T
---
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
-
L
L
--
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
S
R
R
--
L
-
G
T
L
D
Y
L
P
P
E
M
I
------
E
------
G
R
M
H
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
-
A
N
-
T
Y
--
Q
E
T
Y
K
R
-
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
-
S
Q
R
-----
P
M
L
-----
R
E
V
---
L
E
-
H
P
W
I
-----------------------------------------------------------------------------------
310
Blastp_CBE
32.94
31%
-7
- C1 -
-
2WTV
4
AURKA_HUMAN
A:
[18-265]
-------------------------------------
G
R
P
-
L
G
K
G
K
F
G
---
N
V
Y
L
A
R
E
K
Q
S
K
F
I
L
A
L
K
-----------
V
L
F
------
K
------------
A
-------
Q
L
E
K
---
A
-
G
---
V
E
H
Q
L
RRE
V
E
I
Q
S
H
L
R
H
P
N
I
L
R
L
Y
G
Y
F
H
D
A
T
R
V
Y
L
I
L
E
Y
A
P
R
G
E
V
Y
K
----
E
L
Q
K
L
SK
F
D
E
Q
R
T
A
T
---
Y
I
T
E
L
A
N
A
L
S
Y
C
H
-
S
K
R
V
I
H
R
D
I
K
P
E
N
L
-
L
L
--
G
S
A
---
G
E
----
L
K
I
A
D
F
G
W
S
V
------
H
A
P
S
S
R
R
--
L
-
G
T
L
D
Y
L
P
P
E
M
I
------
E
------
G
R
M
H
D
E
K
-
V
D
L
W
S
L
G
V
L
C
Y
E
F
L
V
G
K
P
P
F
E
-
A
N
-
T
Y
--
Q
E
T
Y
K
R
-
I
S
R
V
E
F
T
F
P
D
----
F
V
T
E
G
A
R
D
L
I
S
R
L
L
K
H
N
P
-
S
Q
R
-----
P
M
L
-----
R
E
V
---
L
E
-
H
P
W
I
-----------------------------------------------------------------------------------
401
HHSearch
31.00
39%
-10
- C1 -
-
2X4F
4
MYLK4_HUMAN
A:
[65-355]
--------------------------------------
E
I
-
L
G
G
G
R
F
G
---
Q
V
H
K
C
E
E
T
A
T
G
L
K
L
A
A
K
-----------
I
I
K
------
T
R
-----
G
----
M
K
---------
D
K
---
E
-
E
---
V
K
N
E
I
---
S
V
M
N
Q
L
-
D
H
A
N
L
I
Q
L
Y
D
A
F
E
S
K
N
D
I
V
L
V
M
E
Y
V
D
G
G
E
L
F
D
R
I
I
D
E
-
S
Y
N
--
L
T
E
L
D
T
I
L
---
F
M
K
Q
I
C
E
G
I
R
H
M
H
-
Q
M
Y
I
L
H
L
D
L
K
P
E
N
I
-
L
C
--
V
N
R
-
D
A
K
Q
----
I
K
I
I
D
F
G
L
A
R
R
--
Y
-
K
P
R
E
K
L
K
V
-
N
F
-
G
T
P
E
F
L
A
P
E
V
V
------
N
------
Y
D
F
V
S
F
P
-
T
D
M
W
S
V
G
V
I
A
Y
M
L
L
S
G
L
S
P
F
L
-
G
D
-
N
D
--
A
E
T
L
N
N
-
I
L
A
C
R
W
D
L
E
D
E
E
F
Q
D
I
S
E
E
A
K
E
F
I
S
K
L
L
I
K
E
K
-
S
W
R
-----
I
S
A
-----
S
E
A
---
L
K
-
H
P
W
L
-
S
D
H
K
L
H
S
R
L
-------------------------------------------------------------------------