@TOME V3
(Feb 2022)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : STK16_HUMAN: (2020-09-22 )
MGHALCVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCLRERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTEDQILWLLLGICRGLEAIHAKGYAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALAVQNQLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEALQPPAPGQHTTQI
Atome Classification :
(20 SA)
.........10........20........30........40........50......-..60......-..70...-......80......--..90.-..------.....100.......110.......120.......130.......140...--......150.......160........170.......180--.........190.......200.......210.......220.......230.......240.......250.---.......260.......270.......280.......290.......300...
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MG
H
A
L
C
V
CSR
G
T
V
I
IDNK
R
Y
L
F
I
Q
KLGEGG
F
S
Y
V
D
L
V
E
G
LHDG
H
F
Y
A
L
K
R
I
LCHE
Q
Q
-
D
R
E
E
A
Q
R
E
A
D
-
M
H
R
-
L
FN-H
P
N
I
L
R
L
V
A
Y
C
L
R
E--RGAKH-
E
A
------
W
L
L
L
P
F
F
KRG
T
L
W
N
E
I
E
R
L
K
DKGNFL
T
E
D
Q
I
L
W
L
L
L
G
I
C
R
G
L
E
A
I
H--AKG--YAHRDLKPT
N
I
L
LGDEG-
Q
P
V
L
M
DLGSMN
Q
A
C
I
H
VEGS----R
Q
A
L
T
L
Q
D
WAAQ
R
C
T
I
S
YRAPELFSVQS
H
C
V
IDERT
D
V
W
S
L
G
C
V
L
Y
A
M
M
FGEG
P
Y
D
M
VFQKGD
S
V
A
L
A
V
QN-Q---LSIPQSPR
H
S
S
A
L
R
Q
L
L
N
S
M
MTVDPHQRP
H
I
P
L
L
L
S
Q
L
E
ALQPPAPGQHTTQI
39
HHSearch
99.86
99%
-149
* C1 *
-
2BUJ
2
STK16_HUMAN
A:
[24-310]
------------
V
I
I
D
N
K
H
Y
L
F
I
Q
K
L
G
E
--
F
S
Y
V
D
L
V
E
G
L
H
D
G
H
F
Y
A
L
K
R
I
L
C
H
E
Q
Q
-
D
R
E
E
A
Q
R
E
A
D
-
M
H
R
-
L
F
N
-
H
P
N
I
L
R
L
V
A
Y
C
L
R
E
--
R
G
A
K
H
-
E
A
------
W
L
L
L
P
F
F
K
R
G
T
L
W
N
E
I
E
R
L
K
D
K
G
N
F
L
T
E
D
Q
I
L
W
L
L
L
G
I
C
R
G
L
E
A
I
H
--
A
K
G
--
Y
A
H
R
D
L
K
P
T
N
I
L
L
G
D
E
G
-
Q
P
V
L
M
D
L
G
S
M
N
Q
A
C
I
H
V
E
G
S
----
R
Q
A
L
T
L
Q
D
W
A
A
Q
R
C
T
I
S
Y
R
A
P
E
L
F
S
V
Q
S
H
C
V
I
D
E
R
T
D
V
W
S
L
G
C
V
L
Y
A
M
M
F
G
E
G
P
Y
D
M
V
F
Q
K
G
D
S
V
A
L
A
V
Q
N
-
Q
-----
I
P
Q
S
P
R
H
S
S
A
L
W
Q
L
L
N
S
M
M
T
V
D
P
H
Q
R
P
H
I
P
L
L
L
S
Q
L
E
A
L
Q
P
P
A
P
G
------
1
PsiBlast_PDB
99.86
99%
-149
- C1 -
-
2BUJ
2
STK16_HUMAN
A:
[24-310]
------------
V
I
I
D
N
K
H
Y
L
F
I
Q
K
L
G
E
--
F
S
Y
V
D
L
V
E
G
L
H
D
G
H
F
Y
A
L
K
R
I
L
C
H
E
Q
Q
-
D
R
E
E
A
Q
R
E
A
D
-
M
H
R
-
L
F
N
-
H
P
N
I
L
R
L
V
A
Y
C
L
R
E
--
R
G
A
K
H
-
E
A
------
W
L
L
L
P
F
F
K
R
G
T
L
W
N
E
I
E
R
L
K
D
K
G
N
F
L
T
E
D
Q
I
L
W
L
L
L
G
I
C
R
G
L
E
A
I
H
--
A
K
G
--
Y
A
H
R
D
L
K
P
T
N
I
L
L
G
D
E
G
-
Q
P
V
L
M
D
L
G
S
M
N
Q
A
C
I
H
V
E
G
S
----
R
Q
A
L
T
L
Q
D
W
A
A
Q
R
C
T
I
S
Y
R
A
P
E
L
F
S
V
Q
S
H
C
V
I
D
E
R
T
D
V
W
S
L
G
C
V
L
Y
A
M
M
F
G
E
G
P
Y
D
M
V
F
Q
K
G
D
S
V
A
L
A
V
Q
N
-
Q
-----
I
P
Q
S
P
R
H
S
S
A
L
W
Q
L
L
N
S
M
M
T
V
D
P
H
Q
R
P
H
I
P
L
L
L
S
Q
L
E
A
L
Q
P
P
A
P
G
------
21
Blastp_CBE
96.87
99%
-151
- C1 -
-
2BUJ
2
STK16_HUMAN
B:
[24-308]
------------
V
I
I
D
N
K
H
Y
L
F
I
Q
K
L
G
E
G
G
F
S
Y
V
D
L
V
E
G
L
H
D
G
H
F
Y
A
L
K
R
I
L
C
H
E
Q
Q
-
D
R
E
E
A
Q
R
E
A
D
-
M
H
R
-
L
F
N
-
H
P
N
I
L
R
L
V
A
Y
C
L
R
E
------
H
-
E
A
------
W
L
L
L
P
F
F
K
R
G
T
L
W
N
E
I
E
R
L
K
D
K
G
N
F
L
T
E
D
Q
I
L
W
L
L
L
G
I
C
R
G
L
E
A
I
H
--
A
K
G
--
Y
A
H
R
D
L
K
P
T
N
I
L
L
G
D
E
G
-
Q
P
V
L
M
D
L
G
S
M
N
Q
A
C
I
H
V
E
G
S
----
R
Q
A
L
T
L
Q
D
W
A
A
Q
R
C
T
I
S
Y
R
A
P
E
L
F
S
V
Q
S
H
C
V
I
D
E
R
T
D
V
W
S
L
G
C
V
L
Y
A
M
M
F
G
E
G
P
Y
D
M
V
F
Q
K
G
D
S
V
A
L
A
V
Q
N
-
Q
---
L
----
S
P
R
H
S
S
A
L
W
Q
L
L
N
S
M
M
T
V
D
P
H
Q
R
P
H
I
P
L
L
L
S
Q
L
E
A
L
Q
P
P
A
--------
38
HHSearch
96.06
99%
-148
- C1 -
-
2BUJ
2
STK16_HUMAN
B:
[25-308]
-------------
I
I
D
N
K
H
Y
L
F
I
Q
K
L
G
E
G
G
F
S
Y
V
D
L
V
E
G
L
H
D
G
H
F
Y
A
L
K
R
I
L
C
H
E
Q
Q
-
D
R
E
E
A
Q
R
E
A
D
-
M
H
R
-
L
F
N
-
H
P
N
I
L
R
L
V
A
Y
C
L
R
E
------
H
-
E
A
------
W
L
L
L
P
F
F
K
R
G
T
L
W
N
E
I
E
R
L
K
D
K
G
N
F
L
T
E
D
Q
I
L
W
L
L
L
G
I
C
R
G
L
E
A
I
H
--
A
K
G
--
Y
A
H
R
D
L
K
P
T
N
I
L
L
G
D
E
G
-
Q
P
V
L
M
D
L
G
S
M
N
Q
A
C
I
H
V
E
G
S
----
R
Q
A
L
T
L
Q
D
W
A
A
Q
R
C
T
I
S
Y
R
A
P
E
L
F
S
V
Q
S
H
C
V
I
D
E
R
T
D
V
W
S
L
G
C
V
L
Y
A
M
M
F
G
E
G
P
Y
D
M
V
F
Q
K
G
D
S
V
A
L
A
V
Q
N
-
Q
---
L
----
S
P
R
H
S
S
A
L
W
Q
L
L
N
S
M
M
T
V
D
P
H
Q
R
P
H
I
P
L
L
L
S
Q
L
E
A
L
Q
P
P
A
--------
44
HHSearch
58.53
28%
-51
- C1 -
-
5TE0
10
AAK1_HUMAN
A:
[15-292]
-------------
G
I
G
R
Q
Q
V
T
V
D
E
V
L
A
E
G
G
F
A
I
V
F
L
V
R
T
S
-
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
-
D
L
Q
V
C
K
R
E
I
Q
-
I
M
R
-
D
L
S
G
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
--
V
--
V
W
-
E
V
------
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
--
Q
T
G
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
--
Q
C
K
TP
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
-
H
Y
V
L
C
D
F
G
S
A
T
N
K
F
Q
N
P
Q
T
-----
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
G
E
S
Q
V
A
I
------
C
D
G
-
N
---
F
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
Y
Q
V
S
Y
F
S
F
K
L
L
K
K
---------
6
PsiBlast_PDB
56.81
30%
-32
- C1 -
-
4C57
5
GAK_HUMAN
A:
[21-305]
-----------
T
V
E
L
G
E
L
R
L
R
V
R
R
V
L
A
E
G
G
F
A
F
V
Y
E
A
Q
D
V
G
S
G
R
E
Y
A
L
K
R
L
L
S
N
E
E
E
K
N
R
A
I
I
Q
E
V
C
F
-
M
K
K
-
L
S
G
-
H
P
N
I
---
V
Q
F
C
S
A
A
--
S
I
G
K
E
-
E
S
DTGQAE
F
L
L
L
T
E
L
C
K
G
Q
L
V
E
F
L
K
K
M
E
S
R
G
P
-
L
S
C
D
T
V
L
K
I
F
Y
Q
T
C
R
A
V
Q
H
M
H
--
R
Q
K
PP
I
I
H
R
D
L
K
V
E
N
L
L
L
S
N
Q
G
-
T
I
K
L
C
D
F
G
S
A
T
T
I
S
H
Y
P
D
Y
S
WSAQ
R
R
A
L
-
V
E
E
E
I
T
R
N
T
T
P
M
Y
R
T
P
E
I
I
D
L
Y
S
N
F
P
I
G
E
K
Q
D
I
W
A
L
G
C
I
L
Y
L
L
C
F
R
Q
H
P
F
E
------
D
G
A
K
L
R
I
V
N
G
K
---
Y
S
I
P
P
H
D
T
Q
Y
T
V
F
H
S
L
I
R
A
M
L
Q
V
N
P
E
E
R
L
S
I
A
E
V
V
H
Q
L
Q
E
I
------------
51
HHSearch
52.78
25%
-107
- C1 -
-
5J5T
1
M4K3_HUMAN
A:
[3-266]
----------------
Q
E
D
F
E
L
I
Q
R
I
G
S
G
T
Y
G
D
V
Y
K
A
R
N
V
N
T
G
E
L
A
A
I
K
V
I
K
L
E
P
G
E
-
D
F
A
V
V
Q
Q
E
I
I
-
M
M
K
-
D
C
K
-
H
P
N
I
V
A
Y
F
G
S
Y
L
R
------
R
D
-
K
L
------
W
I
C
M
E
F
C
G
G
G
S
L
Q
D
I
Y
H
V
T
----
G
P
L
S
E
L
Q
I
A
Y
V
S
R
E
T
L
Q
G
L
Y
Y
L
H
--
S
K
G
--
K
M
H
R
D
I
K
G
A
N
I
L
L
T
D
N
G
-
H
V
K
L
A
D
F
G
V
S
A
Q
I
T
A
T
I
-------------
A
---
A
F
I
G
T
P
Y
W
M
A
P
E
V
A
A
V
E
R
K
G
G
Y
N
Q
L
C
D
L
W
A
V
G
I
T
A
I
E
L
A
E
L
Q
P
P
M
F
D
L
H
P
M
R
-
A
L
F
L
M
T
K
S
-
N
FQP
P
K
L
K
D
K
M
K
W
S
N
S
F
H
H
F
V
K
M
A
L
T
K
N
P
K
K
R
P
T
A
E
K
L
L
Q
H
P
F
V
T
------------
2
PsiBlast_PDB
51.82
30%
-25
- C1 -
-
5Y7Z
1
GAK_HUMAN
A:
[24-294]
-------------------------
L
A
E
G
G
F
A
F
V
Y
E
A
Q
D
V
G
S
G
R
E
Y
A
L
K
R
L
L
S
N
E
E
E
K
N
R
A
I
I
Q
E
V
C
F
-
M
K
K
-
L
S
G
-
H
P
N
I
---
V
Q
F
C
S
A
A
--
S
I
G
K
E
-
E
S
DTGQAE
F
L
L
L
T
E
L
C
K
G
Q
L
V
E
F
L
K
K
M
E
S
R
G
P
-
L
S
C
D
T
V
L
K
I
F
Y
Q
T
C
R
A
V
Q
H
M
H
--
R
Q
K
PP
I
I
H
R
D
L
K
V
E
N
L
L
L
S
N
Q
G
-
T
I
K
L
C
D
F
G
S
A
T
T
I
S
H
Y
P
D
Y
S
WSAQ
R
R
A
L
-
V
E
E
E
I
T
R
N
T
T
P
M
Y
R
T
P
E
I
I
D
L
Y
S
N
F
P
I
G
E
K
Q
D
I
W
A
L
G
C
I
L
Y
L
L
C
F
R
Q
H
P
F
E
------
D
G
A
K
L
R
I
V
N
G
K
---
Y
S
I
P
P
H
D
T
Q
Y
T
V
F
H
S
L
I
R
A
M
L
Q
V
N
P
E
E
R
L
S
I
A
E
V
V
H
Q
L
Q
E
I
------------
56
HHSearch
50.80
23%
-120
- C1 -
-
6AO5
1
STK3_HUMAN
A:
[13-264]
--------------------
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
-----
V
V
A
I
K
Q
--------
D
L
Q
E
I
I
K
E
I
S
-
I
M
Q
-
Q
C
D
-
S
P
Y
V
V
K
Y
Y
G
S
Y
F
-----------
L
------
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
L
R
---
N
K
T
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
--
F
M
R
--
K
I
H
R
N
I
K
A
G
N
I
L
L
N
T
E
G
-
H
A
K
L
A
D
F
G
V
A
-------------------------
V
I
G
T
P
F
W
M
A
P
E
V
I
Q
E
---
I
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
-
A
I
F
M
I
P
T
N
P
P
---
P
T
F
R
K
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
P
F
I
K
------------
11
PsiBlast_PDB
50.79
29%
-51
- C1 -
-
4O38
1
GAK_HUMAN
A:
[23-307]
-----------
T
V
E
L
G
E
L
R
L
R
V
R
R
V
L
A
E
G
G
F
A
F
V
Y
E
A
Q
D
V
G
S
G
R
E
Y
A
L
K
R
L
L
S
N
E
E
E
K
N
R
A
I
I
Q
E
V
C
F
-
M
K
K
-
L
S
G
-
H
P
N
I
---
V
Q
F
C
S
A
A
--
S
I
G
K
E
-
E
S
DTGQAE
F
L
L
L
T
E
L
C
K
G
Q
L
V
E
F
L
K
K
M
E
S
R
G
P
-
L
S
C
D
T
V
L
K
I
F
Y
Q
T
C
R
A
V
Q
H
M
H
--
R
Q
K
PP
I
I
H
R
D
L
K
V
E
N
L
L
L
S
N
Q
G
-
T
I
K
L
C
D
F
G
S
A
T
T
I
S
H
Y
P
--------------------------------
L
Y
S
N
F
P
I
G
E
K
Q
D
I
W
A
L
G
C
I
L
Y
L
L
C
F
R
Q
H
P
F
---------------------
Y
S
I
P
P
H
D
T
Q
Y
T
V
F
H
S
L
I
R
A
M
L
Q
V
N
P
E
E
R
L
S
I
A
E
V
V
H
Q
L
Q
E
I
------------
9
PsiBlast_PDB
50.73
30%
-25
- C1 -
-
4WSQ
1
AAK1_HUMAN
A:
[24-276]
-------------------------
L
A
E
G
G
F
A
I
V
F
L
V
R
-
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
-
D
L
Q
V
C
K
R
E
I
Q
-
I
M
R
D
L
S
G
-
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
VS
S
G
D
V
W
-
E
V
------
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
--
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
QC
K
T
P
--
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
-
H
Y
V
L
C
D
F
G
S
A
T
N
K
-
F
Q
N
P
Q
T
----
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
------
G
E
S
Q
V
A
I
C
D
G
-
N
---
F
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
----------------------
12
PsiBlast_PDB
50.57
29%
-12
- C1 -
-
4W9W
7
BMP2K_HUMAN
A:
[17-270]
-----------------------
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
-
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
-
D
L
N
V
C
K
R
E
I
T
I
M
K
E
-
L
S
G
-
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
--
I
S
D
N
V
W
E
V
------
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
--
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
QC
K
T
P
--
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
-
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
----
G
V
N
V
-
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
------
G
E
S
Q
V
A
I
C
D
G
-
N
---
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
----------------------
46
HHSearch
50.44
21%
-83
- C1 -
-
6MYN
1
M3K14_MOUSE
B:
[72-334]
-----------------
H
W
M
T
H
Q
P
R
V
G
R
G
S
F
G
E
V
H
R
M
K
D
K
Q
T
G
F
Q
C
A
V
K
K
V
R
L
E
V
------
F
R
V
E
E
L
V
-
A
C
A
-
G
L
S
-
S
P
R
I
V
P
L
Y
G
A
V
R
E
------
G
P
-
W
V
------
N
I
F
M
E
L
L
E
G
G
S
L
G
Q
L
I
K
Q
M
----
G
C
L
P
E
D
R
A
L
Y
Y
L
G
Q
A
L
E
G
L
E
Y
L
H
--
T
R
R
--
I
L
H
G
D
V
K
A
D
N
V
L
L
S
S
D
G
S
R
A
A
L
C
D
F
G
H
A
L
C
L
Q
P
D
G
L
G
K
--------
S
L
L
T
G
D
Y
I
P
G
T
E
T
H
M
A
P
E
V
V
M
G
---
K
P
C
D
A
K
V
D
I
W
S
S
C
C
M
M
L
H
M
L
N
G
C
H
P
W
T
Q
Y
F
R
G
P
L
--
C
L
K
I
A
S
-
E
PP-
P
I
R
E
I
P
P
S
C
A
P
L
T
A
Q
A
I
Q
E
G
L
R
K
E
P
V
H
R
A
S
A
M
E
L
R
R
K
V
G
K
A
L
Q
E
V
G
G
------
3
PsiBlast_PDB
50.29
30%
-32
- C1 -
-
5Y80
2
GAK_HUMAN
A:
[24-294]
-------------------------
L
A
E
G
G
F
A
F
V
Y
E
A
Q
D
V
G
S
G
R
E
Y
A
L
K
R
L
L
S
N
E
E
E
K
N
R
A
I
I
Q
E
V
C
F
-
M
K
K
-
L
S
G
-
H
P
N
I
---
V
Q
F
C
S
A
A
--
S
I
G
K
E
-
E
S
DTGQAE
F
L
L
L
T
E
L
C
K
G
Q
L
V
E
F
L
K
K
M
---
G
P
-
L
S
C
D
T
V
L
K
I
F
Y
Q
T
C
R
A
V
Q
H
M
H
--
R
Q
K
PP
I
I
H
R
D
L
K
V
E
N
L
L
L
S
N
Q
G
-
T
I
K
L
C
D
F
G
S
A
T
T
I
S
H
Y
P
D
Y
S
WSAQ
R
R
A
L
-
V
E
E
E
I
T
R
N
T
T
P
M
Y
R
T
P
E
I
I
D
L
Y
S
N
F
P
I
G
E
K
Q
D
I
W
A
L
G
C
I
L
Y
L
L
C
F
R
Q
H
P
F
E
------
D
G
A
K
L
R
I
V
N
G
K
---
Y
S
I
P
P
H
D
T
Q
Y
T
V
F
H
S
L
I
R
A
M
L
Q
V
N
P
E
E
R
L
S
I
A
E
V
V
H
Q
L
Q
E
I
------------
15
PsiBlast_PDB
49.64
29%
-14
- C1 -
-
5I3O
1
BMP2K_HUMAN
A:
[14-267]
-----------------------
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
-
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
-
D
L
N
V
C
K
R
E
I
T
I
M
K
E
-
L
S
G
-
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
--
I
S
D
N
V
W
E
V
------
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
--
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
QC
K
T
P
--
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
-
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
----
G
V
N
V
-
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
------
G
E
S
Q
V
A
I
C
D
G
-
N
---
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
----------------------
14
PsiBlast_PDB
49.52
29%
-12
- C1 -
-
5IKW
1
BMP2K_HUMAN
A:
[20-273]
-----------------------
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
-
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
-
D
L
N
V
C
K
R
E
I
T
I
M
K
E
-
L
S
G
-
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
--
I
S
D
N
V
W
E
V
------
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
--
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
QC
K
T
P
--
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
-
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
----
G
V
N
V
-
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
------
G
E
S
Q
V
A
I
C
D
G
-
N
---
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
----------------------
7
PsiBlast_PDB
49.43
30%
-54
- C1 -
-
4Y8D
1
GAK_HUMAN
A:
[21-305]
-----------
T
V
E
L
G
E
L
R
L
R
V
R
R
V
L
A
E
G
G
F
A
F
V
Y
E
A
Q
D
V
G
S
G
R
E
Y
A
L
K
R
L
L
S
N
E
E
E
K
N
R
A
I
I
Q
E
V
C
F
-
M
K
K
-
L
S
G
-
H
P
N
I
---
V
Q
F
C
S
A
A
--
S
I
G
K
E
-
E
S
DTGQAE
F
L
L
L
T
E
L
C
K
G
Q
L
V
E
F
L
K
K
M
E
S
R
G
P
-
L
S
C
D
T
V
L
K
I
F
Y
Q
T
C
R
A
V
Q
H
M
H
--
R
Q
K
PP
I
I
H
R
D
L
K
V
E
N
L
L
L
S
N
Q
G
-
T
I
K
L
C
D
F
G
S
A
T
T
I
S
H
Y
P
---------------------------------
Y
S
N
F
P
I
G
E
K
Q
D
I
W
A
L
G
C
I
L
Y
L
L
C
F
R
Q
H
P
F
----------------------
S
I
P
P
H
D
T
Q
Y
T
V
F
H
S
L
I
R
A
M
L
Q
V
N
P
E
E
R
L
S
I
A
E
V
V
H
Q
L
Q
E
I
------------
8
PsiBlast_PDB
48.93
30%
-12
- C1 -
-
5TE0
10
AAK1_HUMAN
A:
[27-279]
-------------------------
L
A
E
G
G
F
A
I
V
F
L
V
R
-
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
-
D
L
Q
V
C
K
R
E
I
Q
-
I
M
R
D
L
S
G
-
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
V----
V
W
-
E
V
------
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
--
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
QC
K
T
P
--
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
-
H
Y
V
L
C
D
F
G
S
A
T
N
K
-
F
Q
N
P
Q
T
----
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
------
G
E
S
Q
V
A
I
C
D
G
-
N
---
F
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
----------------------
10
PsiBlast_PDB
48.74
30%
-23
- C1 -
-
5L4Q
2
AAK1_HUMAN
A:
[26-278]
-------------------------
L
A
E
G
G
F
A
I
V
F
L
V
R
-
T
S
N
G
M
K
C
A
L
K
R
M
F
V
N
N
E
H
-
D
L
Q
V
C
K
R
E
I
Q
-
I
M
R
D
L
S
G
-
H
K
N
I
V
G
Y
I
D
S
S
I
N
N
VS
S
G
D
V
W
-
E
V
------
L
I
L
M
D
F
C
R
G
G
Q
V
V
N
L
M
N
Q
R
L
Q
T
G
--
F
T
E
N
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
QC
K
T
P
--
I
I
H
R
D
L
K
V
E
N
I
L
L
H
D
R
G
-
H
Y
V
L
C
D
F
G
S
A
T
N
K
-
F
Q
N
P
Q
T
----
E
G
V
N
A
V
E
D
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
V
N
L
Y
S
G
K
I
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
Y
F
T
L
P
F
-----------------
N
---
F
T
I
P
D
N
S
R
Y
S
Q
D
M
H
C
L
I
R
Y
M
L
E
P
D
P
D
K
R
P
D
I
----------------------
16
PsiBlast_PDB
48.36
29%
-11
- C1 -
-
5I3R
1
BMP2K_HUMAN
A:
[14-267]
-----------------------
E
S
L
A
E
G
G
F
S
T
V
F
L
V
R
-
T
H
G
G
I
R
C
A
L
K
R
M
Y
V
N
N
M
P
-
D
L
N
V
C
K
R
E
I
T
I
M
K
E
-
L
S
G
-
H
K
N
I
V
G
Y
L
D
C
A
V
N
S
--
I
S
D
N
V
W
E
V
------
L
I
L
M
E
Y
C
R
A
G
Q
V
V
N
Q
M
N
K
K
L
Q
T
G
--
F
T
E
P
E
V
L
Q
I
F
C
D
T
C
E
A
V
A
R
L
H
QC
K
T
P
--
I
I
H
R
D
L
K
V
E
N
I
L
L
N
D
G
G
-
N
Y
V
L
C
D
F
G
S
A
T
N
K
F
L
N
P
Q
K
D
----
G
V
N
V
-
V
E
E
E
I
K
K
Y
T
T
L
S
Y
R
A
P
E
M
I
N
L
Y
G
G
K
P
I
T
T
K
A
D
I
W
A
L
G
C
L
L
Y
K
L
C
F
F
T
L
P
F
------
G
E
S
Q
V
A
I
C
D
G
-
N
---
F
T
I
P
D
N
S
R
Y
S
R
N
I
H
C
L
I
R
F
M
L
E
P
D
P
E
H
R
P
D
I
----------------------