@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : TYRO3_HUMAN: (2020-09-24 )
MALRRSMGRPGLPPLPLPPPPRLGLLLAALASLLLPESAAAGLKLMGAPVKLTVSQGQPVKLNCSVEGMEEPDIQWVKDGAVVQNLDQLYIPVSEQHWIGFLSLKSVERSDAGRYWCQVEDGGETEISQPVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIVWWRGTTKIGGPAPSPSVLNVTGVTQSTMFSCEAHNLKGLASSRTATVHLQALPAAPFNITVTKLSSSNASVAWMPGADGRALLQSCTVQVTQAPGGWEVLAVVVPVPPFTCLLRDLVPATNYSLRVRCANALGPSPYADWVPFQTKGLAPASAPQNLHAIRTDSGLILEWEEVIPEAPLEGPLGPYKLSWVQDNGTQDELTVEGTRANLTGWDPQKDLIVRVCVSNAVGCGPWSQPLVVSSHDRAGQQGPPHSRTSWVPVVLGVLTALVTAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLIRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVQSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEDVYDLMYQCWSADPKQRPSFTCLRMELENILGQLSVLSASQDPLYINIERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSDCRYILTPGGLAEQPGQAEHQPESPLNETQRLLLLQQGLLPHSSC
Atome Classification :
(378 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510....------...--520.........530...---..----..--540---.---.......550.......560.--......570...-.-...580.......590.......600.......610.......------------620----.--....----..--.630---......---...640.......650.......660.---.---....----.670.......680...--.--...690.......700.......710.......720......-.730.......740.....-------..750.......760.......770.......----780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
M
A
L
R
R
SMGRPGLPPLPLPPPP
R
L
G
L
L
L
A
A
L
A
S
LLLPESAAAG
L
K
LMGA
P
V
K
L
T
VSQGQ
P
V
K
L
N
C
SVEGMEEPD
I
Q
W
VKD
G
A
V
V
Q
N
L
D
Q
LYIPVSEQ
H
W
I
G
F
L
S
L
K
S
VERSDA
G
R
Y
W
C
QVEDGGETEISQ
P
V
W
L
T
VEG
V
P
F
F
T
VEPKDLAVPPNA
P
F
Q
L
S
CEAVGPPE
P
V
T
I
V
W
WRGTTKIGGPAPSP
S
V
L
N
V
TGVTQ
S
T
M
F
S
CEAHNLKGLASS
R
T
A
T
V
H
L
QALPAAP
F
N
I
T
V
T
K
LSSSNA
S
V
A
W
MPGA
D
G
R
A
L
L
Q
SC
T
V
Q
V
T
QAPGG
W
E
V
L
A
V
V
VPVP
P
F
T
C
L
L
R
D
LVPATN
Y
S
L
R
V
R
C
ANALGPSPYADWVPFQTKGLAPASAPQ
N
L
H
A
I
RTDS
G
L
I
L
E
W
E
E
VIPEAPLEGPLGP
Y
K
L
S
W
V
QDNGTQD
E
L
T
V
EGTRANLTGWDP
Q
K
D
L
I
V
R
V
C
V
SNAVGCGPWSQ
P
L
V
V
SSHDRAGQQGPPHSRT
S
W
V
P
V
V
L
G
V
L
T
A
L
V
T
A
A
A
L
A
L
I
L
L
R
K
R
RKETR
F
G
Q
A
F
D
S
V
M
ARGEP
A
V
H
F
R
A
A
R
SFNRE
R
P
E
R
I
E
A
T
L
D
SLGI
S
D
E
L
K
E
K
L
E
D
VLIP
E
Q
------
Q
F
T
--
L
--
G
R
MLGKGEFGS
V
R
E
A
---
Q
L----KQ--ED----G---
S
F
V
K
V
A
V
K
M
L
K
A
D
IIA
S
S
D
I
E
--
E
F
L
R
E
A
A
C
M
K
EF-D-H
P
H
V
A
K
L
V
G
V
S
L
R
SRAKGRLP
I
P
M
V
I
L
P
F
MKHG
D
L
H
A
F
L
L
A
S
R
------------IG-----E--NPFN----
L
P
--
L
Q
-----
T
L
I
R
F
M
---
V
D
I
A
C
G
M
E
Y
L
S
SR
N
F
I
H
R
D
L
A
ARNC
M
L
---
A
---
E
D
M
T
----
V
C
V
A
DFGLS
R
K
IYSG
D
Y
--
Y
--RQGCASKLP
V
K
W
L
A
L
E
S
LADN
L
Y
T
V
QS
D
V
W
A
F
G
V
T
M
W
E
I
M
TR-GQTPYAGIEN
A
E
I
Y
N
Y
L
IG-------GNRLKQ
P
P
E
C
M
E
D
V
Y
D
L
M
Y
Q
C
WSADPKQRPS
F
----
T
C
L
R
M
E
L
E
N
I
L
G
Q
L
S
VLSASQD
P
L
Y
I
N
I
ERAEEPTAGGSLELPGRDQPYSGAGDGSGMGAVGGTPSD
C
R
Y
I
LTPGGLAEQPGQAEHQPES
P
L
N
E
T
Q
R
L
L
L
L
Q
QGLLPHSSC
557
HHSearch
87.29
98%
-188
- C5 -
-
3QUP
1
A:
[16-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
P
---------
F
T
--
L
--
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
---
Q
L
--------------------
V
K
V
A
V
K
M
L
------
S
S
D
I
E
--
E
F
L
R
E
A
A
C
M
K
E
F
-
D
-
H
P
H
V
A
K
L
V
G
V
S
L
R
S
-------
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
------------
I
----------
P
F
N
----
L
P
--
L
Q
-----
T
L
V
R
F
M
---
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
---
A
---
E
D
M
T
----
V
C
V
A
D
F
G
L
---------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
-
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
----
T
C
L
R
M
E
L
E
N
I
L
G
H
--------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.07
97%
-188
- C5 -
-
3QUP
1
A:
[16-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
P
---------
F
T
--
L
--
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
---
Q
L
--------------------
V
K
V
A
V
K
M
L
------
S
S
D
I
E
--
E
F
L
R
E
A
A
C
M
K
E
F
-
D
-
H
P
H
V
A
K
L
V
G
V
S
L
R
S
-------
I
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
------------
I
----------
P
F
N
----
L
P
--
L
Q
-----
T
L
V
R
F
M
---
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
---
A
---
E
D
M
T
----
V
C
V
A
D
F
G
L
---------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
-
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
----
T
C
L
R
M
E
L
E
N
I
L
G
H
--------------------------------------------------------------------------------------------------
23
Blastp_CBE
83.72
63%
-151
- C5 -
-
5U6B
1
UFO_HUMAN
B:
[3-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
G
I
S
E
E
L
K
E
K
L
R
D
V
M
V
D
R
H
------
K
V
A
--
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
L
----
N
Q
------------
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
--
D
F
L
S
E
A
V
C
M
K
E
F
-
D
-
H
P
N
V
M
R
L
I
G
V
C
F
----
R
E
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
Y
S
R
------------
L
G
-----
D
--
Q
P
V
Y
----
L
P
--
T
Q
-----
M
L
V
K
F
M
---
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
---
N
---
E
N
M
S
----
V
C
V
A
D
F
G
L
S
K
K
I
Y
N
G
D
Y
--
Y
-----
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
----
T
E
L
R
E
D
L
E
N
T
L
K
A
L
-------------------------------------------------------------------------------------------------
21
Blastp_CBE
83.69
63%
-152
- C5 -
-
5U6B
1
D:
[3-299]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
G
I
S
E
E
L
K
E
K
L
R
D
V
M
V
D
R
H
------
K
V
A
--
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
L
----
N
Q
------------
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
--
D
F
L
S
E
A
V
C
M
K
E
F
-
D
-
H
P
N
V
M
R
L
I
G
V
C
F
----
R
E
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
Y
S
R
------------
L
G
-----
D
--
Q
P
V
Y
----
L
P
--
T
Q
-----
M
L
V
K
F
M
---
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
---
N
---
E
N
M
S
----
V
C
V
A
D
F
G
L
S
K
K
I
Y
N
G
D
Y
--
Y
-----
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
----
T
E
L
R
E
D
L
E
N
T
L
K
A
L
-------------------------------------------------------------------------------------------------
559
HHSearch
82.41
63%
-154
- C5 -
-
5U6B
1
UFO_HUMAN
B:
[11-300]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
K
L
R
D
V
M
V
D
R
H
------
K
V
A
--
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
L
----
N
Q
--------
S
----
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
--
D
F
L
S
E
A
V
C
M
K
E
F
-
D
-
H
P
N
V
M
R
L
I
G
V
C
F
----
R
E
S
F
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
Y
S
R
------------
L
G
-----
D
--
Q
P
V
Y
----
L
P
--
T
Q
-----
M
L
V
K
F
M
---
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
---
N
---
E
N
M
S
----
V
C
V
A
D
F
G
L
S
K
K
I
Y
N
G
D
Y
--
Y
-----
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
----
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
82.26
63%
-162
- C5 -
-
5U6C
1
MERTK_HUMAN
A:
[23-312]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
M
R
L
L
G
V
C
I
E
M
-----
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
567
HHSearch
81.85
63%
-165
- C5 -
-
3BRB
2
B:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
-
Q
G
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
32
Blastp_CBE
81.05
63%
-165
- C5 -
-
3BRB
2
B:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
560
HHSearch
81.02
63%
-156
- C5 -
-
5U6B
1
UFO_HUMAN
A:
[11-301]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
E
K
L
R
D
V
M
V
D
R
H
------
K
V
A
--
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
L
----
N
Q
--
D
D
----
S
----
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
--
D
F
L
S
E
A
V
C
M
K
E
F
-
D
-
H
P
N
V
M
R
L
I
G
V
C
F
Q
-------
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
Y
S
R
------------
L
G
-----
D
--
Q
P
V
Y
----
L
P
--
T
Q
-----
M
L
V
K
F
M
---
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
---
N
---
E
N
M
S
----
V
C
V
A
D
F
G
L
S
K
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
----
T
E
L
R
E
D
L
E
N
T
L
K
A
L
P
P
-----------------------------------------------------------------------------------------------
2
PsiBlast_PDB
80.87
97%
-172
- C5 -
-
4FEQ
1
A:
[22-300]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
------
Q
F
T
--
L
--
G
R
M
L
G
K
---
G
S
V
R
E
A
---
Q
L
----
K
----
D
----
G
---
S
F
V
K
V
A
V
K
M
L
--------------
F
L
R
E
A
A
C
M
K
E
F
-
D
-
H
P
H
V
A
K
L
V
G
V
S
-----------
P
M
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
------------
I
------------------
P
--
L
Q
-----
T
L
V
R
F
M
---
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
---
A
---
E
D
M
T
----
V
C
V
A
D
F
G
------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
-
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
----
T
C
L
R
M
E
L
E
N
I
L
G
H
L
-------------------------------------------------------------------------------------------------
22
Blastp_CBE
80.74
63%
-156
- C5 -
-
5U6B
1
UFO_HUMAN
C:
[10-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
K
L
R
D
V
M
V
D
R
H
------
K
V
A
--
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
L
----
N
Q
--
D
D
--------
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
--
D
F
L
S
E
A
V
C
M
K
E
F
-
D
-
H
P
N
V
M
R
L
I
G
V
C
F
Q
-------
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
Y
S
R
------------
L
G
-----
D
--
Q
P
V
Y
----
L
P
--
T
Q
-----
M
L
V
K
F
M
---
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
---
N
---
E
N
M
S
----
V
C
V
A
D
F
G
L
S
K
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
----
T
E
L
R
E
D
L
E
N
T
L
K
A
L
-------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
80.34
63%
-178
- C5 -
-
3BRB
2
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
---
N
S
S
Q
R
E
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
--------
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
S
--------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
565
HHSearch
80.33
63%
-178
- C5 -
-
3BRB
2
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
---
N
S
S
Q
R
E
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
--------
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
S
--------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
80.24
63%
-157
- C5 -
-
5U6B
1
UFO_HUMAN
A:
[10-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
K
L
R
D
V
M
V
D
R
H
------
K
V
A
--
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
L
----
N
Q
--
D
D
--------
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
E
--
D
F
L
S
E
A
V
C
M
K
E
F
-
D
-
H
P
N
V
M
R
L
I
G
V
C
F
Q
-------
P
A
P
V
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
L
Y
S
R
------------
L
G
-----
D
--
Q
P
V
Y
----
L
P
--
T
Q
-----
M
L
V
K
F
M
---
A
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
---
N
---
E
N
M
S
----
V
C
V
A
D
F
G
L
S
K
--------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
----
T
E
L
R
E
D
L
E
N
T
L
K
A
L
-------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
80.22
63%
-181
- C5 -
-
3TCP
1
MERTK_HUMAN
A:
[26-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
-----
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
-------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
24
Blastp_CBE
79.81
63%
-179
- C5 -
-
5U6C
1
B:
[26-312]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
---------
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
M
R
L
L
G
V
C
I
E
M
S
S
Q
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
-----------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
79.76
63%
-173
- C5 -
-
3BPR
1
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
------
R
E
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
79.71
63%
-173
- C5 -
-
5K0K
1
MERTK_HUMAN
A:
[26-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
-------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
34
Blastp_CBE
79.56
63%
-174
- C5 -
-
3BPR
1
MERTK_HUMAN
C:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
--------
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
------
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
33
Blastp_CBE
79.39
63%
-174
- C5 -
-
3BPR
1
D:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
--------
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.25
63%
-172
- C5 -
-
5K0X
1
MERTK_HUMAN
A:
[25-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
--
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
-------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
564
HHSearch
79.23
63%
-171
- C5 -
-
5K0X
1
MERTK_HUMAN
A:
[25-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
--
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
-------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------------------
35
Blastp_CBE
78.82
63%
-177
- C5 -
-
3BPR
1
MERTK_HUMAN
B:
[25-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
L
-------
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
--------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
31
Blastp_CBE
78.31
63%
-174
- C5 -
-
3TCP
1
B:
[25-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
----------------
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
-----------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
77.70
63%
-177
- C5 -
-
2P0C
2
MERTK_HUMAN
A:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
--
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
-------------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
--------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
77.68
63%
-172
- C5 -
-
6MEP
1
MERTK_HUMAN
A:
[25-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
--------------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
----------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
S
---------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
36
Blastp_CBE
77.41
63%
-175
- C5 -
-
2P0C
1
B:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
-------------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
--------
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
L
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
77.22
63%
-171
- C5 -
-
4MH7
1
MERTK_HUMAN
A:
[26-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
-------------------
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
26
Blastp_CBE
76.95
63%
-173
- C5 -
-
5K0X
1
B:
[24-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
--
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
--------------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
27
Blastp_CBE
76.76
63%
-172
- C5 -
-
5K0K
1
B:
[26-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
--
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
------------------
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
76.64
63%
-167
- C5 -
-
4MHA
1
MERTK_HUMAN
A:
[29-310]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
E
--
E
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
-------
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
30
Blastp_CBE
75.56
63%
-183
- C5 -
-
4M3Q
1
B:
[26-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
-----
G
S
V
M
E
G
---
N
L
----
K
--------------
S
L
K
V
A
V
K
T
M
--------------
F
L
S
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
---------
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
G
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
75.43
63%
-174
- C5 -
-
4M3Q
1
MERTK_HUMAN
A:
[27-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
---------------------
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
--
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
28
Blastp_CBE
75.28
63%
-168
- C5 -
-
4MHA
1
B:
[26-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
----------------------
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
I
E
M
S
S
Q
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
25
Blastp_CBE
75.12
63%
-175
- C5 -
-
6MEP
1
B:
[27-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
-------------------
E
A
A
C
M
K
D
F
-
S
-
H
P
N
V
I
R
L
L
G
V
C
-----------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
--
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
74.58
63%
-173
- C5 -
-
5TD2
1
MERTK_HUMAN
A:
[1-285]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
M
------------------
A
A
C
M
K
D
F
-
S
-
H
P
N
V
M
R
L
L
G
V
C
I
E
M
S
S
------
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
------------------------
P
V
K
W
I
A
I
E
S
L
----
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
161
Blastp_CBE
73.97
42%
-146
- C5 -
-
2Z60
1
ABL1_MOUSE
A:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
269
Blastp_CBE
73.90
42%
-147
- C5 -
-
2FO0
3
ABL1_HUMAN
A:
[220-479]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
208
Blastp_CBE
73.88
42%
-147
- C5 -
-
2G1T
1
ABL1_HUMAN
B:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
193
Blastp_CBE
73.84
42%
-142
- C5 -
-
2QOH
1
ABL1_MOUSE
A:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.73
63%
-170
- C5 -
-
5TC0
1
MERTK_HUMAN
A:
[28-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
V
I
D
R
N
------
L
L
I
--
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
L
----
K
Q
--
E
D
----
G
---
T
S
L
K
V
A
V
K
T
----------------------
M
K
D
F
-
S
-
H
P
N
V
M
R
L
L
G
V
C
I
E
M
S
S
Q
G
-
I
P
K
P
M
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
L
Y
S
R
------------
L
E
-----
T
--
G
P
K
H
----
I
P
--
L
Q
-----
T
L
L
K
F
M
---
V
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
---
R
---
D
D
M
T
----
V
C
V
A
D
F
-----------------------
M
P
V
K
W
I
A
I
E
-------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
----
S
V
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------------------
212
Blastp_CBE
73.26
42%
-141
- C5 -
-
2F4J
1
ABL1_HUMAN
A:
[17-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
215
Blastp_CBE
73.11
42%
-145
- C5 -
-
2G2H
1
ABL1_HUMAN
B:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
232
Blastp_CBE
73.08
42%
-148
- C5 -
-
3DK3
1
ABL1_MOUSE
A:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
-------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
F
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
216
Blastp_CBE
73.08
42%
-141
- C5 -
-
2G2H
1
ABL1_HUMAN
A:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
198
Blastp_CBE
73.05
42%
-144
- C5 -
-
4WA9
1
ABL1_HUMAN
B:
[17-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
196
Blastp_CBE
73.04
42%
-150
- C5 -
-
4ZOG
2
ABL1_HUMAN
B:
[15-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
265
Blastp_CBE
73.00
42%
-148
- C5 -
-
1OPK
3
ABL1_MOUSE
A:
[223-482]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
164
Blastp_CBE
72.90
42%
-149
- C5 -
-
4TWP
1
ABL1_HUMAN
B:
[11-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
206
Blastp_CBE
72.78
42%
-146
- C5 -
-
2G1T
1
ABL1_HUMAN
D:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
250
Blastp_CBE
72.70
42%
-144
- C5 -
-
2HZI
1
ABL1_HUMAN
A:
[20-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
181
Blastp_CBE
72.61
42%
-143
- C5 -
-
1M52
3
ABL1_MOUSE
B:
[21-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
159
Blastp_CBE
72.58
42%
-141
- C5 -
-
3IK3
1
ABL1_MOUSE
B:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
197
Blastp_CBE
72.57
42%
-144
- C5 -
-
4ZOG
5
ABL1_HUMAN
A:
[15-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------------------
190
Blastp_CBE
72.50
42%
-148
- C5 -
-
3KF4
1
ABL1_MOUSE
B:
[16-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------------------
279
Blastp_CBE
72.38
42%
-149
- C5 -
-
1OPL
2
ABL1_HUMAN
A:
[262-521]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------------
R
Q
-----
E
----------
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
366
Blastp_CBE
72.36
37%
-167
- C5 -
-
4D4V
2
B:
[5-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
------
R
I
E
--
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
---
I
Y
----
M
S
--
P
E
----
N
---
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
--
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
-
H
P
H
I
V
K
L
I
G
V
I
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------------------------
F
S
----
L
D
--
L
A
-----
S
L
I
L
Y
A
---
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
---
A
T
D
C
----
V
K
L
G
D
F
G
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
207
Blastp_CBE
72.34
42%
-144
- C5 -
-
2G1T
1
ABL1_HUMAN
C:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
209
Blastp_CBE
72.23
42%
-145
- C5 -
-
2G1T
1
ABL1_HUMAN
A:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
191
Blastp_CBE
72.23
42%
-144
- C5 -
-
3KF4
1
ABL1_MOUSE
A:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
--------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
192
Blastp_CBE
72.13
42%
-144
- C5 -
-
2QOH
1
ABL1_MOUSE
B:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
---
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
283
Blastp_CBE
72.10
39%
-138
- C5 -
-
3GVU
2
ABL2_HUMAN
A:
[15-289]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
E
N
L
Y
F
Q
S
M
D
K
W
E
M
E
R
T
------
D
I
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
------
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
E
E
----
V
T
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
V
----
V
K
V
A
D
F
G
L
S
R
----
G
D
T
--
Y
--
T
----
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-------
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----
A
E
T
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------------------
165
Blastp_CBE
72.10
42%
-151
- C5 -
-
4TWP
1
ABL1_HUMAN
A:
[11-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
--------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
282
Blastp_CBE
72.09
39%
-143
- C5 -
-
3HMI
1
ABL2_HUMAN
A:
[25-289]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
K
W
E
M
E
R
T
------
D
I
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
L
E
------
P
P
F
Y
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
E
E
----
V
T
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
V
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-------
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
----
A
E
T
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------------------
182
Blastp_CBE
72.06
42%
-141
- C5 -
-
1M52
1
ABL1_MOUSE
A:
[21-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
162
Blastp_CBE
72.06
42%
-135
- C5 -
-
3OY3
1
ABL1_MOUSE
B:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
189
Blastp_CBE
72.03
42%
-134
- C5 -
-
3KFA
1
ABL1_MOUSE
A:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
226
Blastp_CBE
71.96
42%
-145
- C5 -
-
3PYY
1
ABL1_HUMAN
A:
[29-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
-------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
-------------------------------------------------------------------------------------------------
179
Blastp_CBE
71.92
42%
-143
- C5 -
-
1OPJ
2
ABL1_MOUSE
B:
[21-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
220
Blastp_CBE
71.76
42%
-148
- C5 -
-
6NPV
2
ABL1_HUMAN
A:
[29-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
--------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
-------------------------------------------------------------------------------------------------
188
Blastp_CBE
71.76
42%
-132
- C5 -
-
3KFA
1
ABL1_MOUSE
B:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
248
Blastp_CBE
71.74
42%
-141
- C5 -
-
3CS9
1
ABL1_HUMAN
A:
[20-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
-------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
160
Blastp_CBE
71.72
42%
-144
- C5 -
-
3IK3
1
ABL1_MOUSE
A:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
-------
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
180
Blastp_CBE
71.58
42%
-141
- C5 -
-
1OPJ
2
ABL1_MOUSE
A:
[21-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
327
Blastp_CBE
71.48
37%
-165
- C5 -
-
2IJM
1
FAK1_HUMAN
A:
[6-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
------
R
I
E
--
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
---
I
Y
----
M
S
--
P
E
----
N
---
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
--
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
-
H
P
H
I
V
K
L
I
G
V
I
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------------------------
Y
S
----
L
D
--
L
A
-----
S
L
I
L
Y
A
---
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
---
S
N
D
C
----
V
K
L
G
D
F
G
L
S
--------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
231
Blastp_CBE
71.35
42%
-148
- C5 -
-
3DK3
1
ABL1_MOUSE
B:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
F
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
169
Blastp_CBE
71.31
42%
-145
- C5 -
-
6HD4
3
ABL1_MOUSE
A:
[21-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
-
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
224
Blastp_CBE
71.25
42%
-149
- C5 -
-
6NPE
2
ABL1_HUMAN
A:
[29-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
--------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
-------------------------------------------------------------------------------------------------
187
Blastp_CBE
71.18
42%
-150
- C5 -
-
3OXZ
1
ABL1_MOUSE
A:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
---------------
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
356
Blastp_CBE
71.11
37%
-164
- C5 -
-
6GCX
1
FAK1_CHICK
A:
[4-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
------
R
I
E
--
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
---
I
Y
----
M
S
--
P
E
----
N
---
P
A
M
A
V
A
I
K
T
C
K
-
N
--
S
D
S
V
R
E
--
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
-
H
P
H
I
V
K
L
I
G
V
I
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------------------------
F
S
----
L
D
--
L
A
-----
S
L
I
L
Y
A
---
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
---
A
T
D
C
----
V
K
L
G
D
F
G
L
S
R
-------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
237
Blastp_CBE
71.08
42%
-142
- C5 -
-
2HYY
1
ABL1_HUMAN
D:
[16-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
278
Blastp_CBE
71.06
42%
-146
- C5 -
-
1OPL
1
ABL1_HUMAN
B:
[262-518]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------------
R
Q
-----
E
----------
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
299
Blastp_CBE
71.05
36%
-162
- C5 -
-
4EBV
3
A:
[28-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
S
T
R
D
Y
E
I
Q
R
E
------
R
I
E
--
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
---
I
Y
----
M
S
--
P
E
----
N
---
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
--
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
-
H
P
H
I
V
K
L
I
G
V
I
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------------------------
Y
S
----
L
D
--
L
A
-----
S
L
I
L
Y
A
---
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
---
S
N
D
C
----
V
K
L
G
D
F
G
L
--------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
201
Blastp_CBE
71.05
42%
-132
- C5 -
-
2HIW
1
ABL1_HUMAN
A:
[18-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
174
Blastp_CBE
71.05
42%
-142
- C5 -
-
3MS9
2
ABL1_MOUSE
B:
[21-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
204
Blastp_CBE
71.04
42%
-147
- C5 -
-
3UE4
1
ABL1_HUMAN
B:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
167
Blastp_CBE
71.03
42%
-146
- C5 -
-
6HD6
2
ABL1_MOUSE
A:
[21-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
--
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
251
Blastp_CBE
71.00
42%
-145
- C5 -
-
3QRK
1
ABL1_HUMAN
A:
[21-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----------------------------------------------------------------------------------------------------
172
Blastp_CBE
70.91
42%
-145
- C5 -
-
3MSS
2
ABL1_MOUSE
B:
[21-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
298
Blastp_CBE
70.83
36%
-165
- C5 -
-
4EBW
1
A:
[29-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
R
D
Y
E
I
Q
R
E
------
R
I
E
--
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
---
I
Y
----
M
S
--------
N
---
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
--
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
-
H
P
H
I
V
K
L
I
G
V
I
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------------------------
Y
S
----
L
D
--
L
A
-----
S
L
I
L
Y
A
---
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
---
S
N
D
C
----
V
K
L
G
D
F
G
L
--------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
222
Blastp_CBE
70.79
42%
-148
- C5 -
-
6NPU
2
ABL1_HUMAN
A:
[29-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
--------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
-------------------------------------------------------------------------------------------------
185
Blastp_CBE
70.75
42%
-132
- C5 -
-
1FPU
1
ABL1_MOUSE
B:
[21-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
------
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
163
Blastp_CBE
70.66
42%
-134
- C5 -
-
3OY3
1
ABL1_MOUSE
A:
[16-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
211
Blastp_CBE
70.62
42%
-150
- C5 -
-
3QRJ
1
ABL1_HUMAN
A:
[21-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
--------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
-----------------------------------------------------------------------------------------------------
253
Blastp_CBE
70.59
42%
-141
- C5 -
-
3QRI
1
ABL1_HUMAN
A:
[21-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
170
Blastp_CBE
70.57
42%
-143
- C5 -
-
3MSS
2
ABL1_MOUSE
D:
[21-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
239
Blastp_CBE
70.50
42%
-137
- C5 -
-
2HYY
1
ABL1_HUMAN
B:
[16-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
-
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
249
Blastp_CBE
70.43
42%
-153
- C5 -
-
2HZI
1
ABL1_HUMAN
B:
[20-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
240
Blastp_CBE
70.43
42%
-134
- C5 -
-
2HYY
1
ABL1_HUMAN
A:
[16-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
-
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
228
Blastp_CBE
70.43
42%
-142
- C5 -
-
6BL8
1
ABL1_HUMAN
A:
[11-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
F
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
177
Blastp_CBE
70.34
42%
-144
- C5 -
-
3K5V
2
ABL1_MOUSE
A:
[21-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
-
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
238
Blastp_CBE
70.33
42%
-144
- C5 -
-
2HYY
1
ABL1_HUMAN
C:
[16-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
-
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
---
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
176
Blastp_CBE
70.21
42%
-143
- C5 -
-
3K5V
2
ABL1_MOUSE
B:
[21-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
---
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
168
Blastp_CBE
70.21
42%
-145
- C5 -
-
6HD4
2
ABL1_MOUSE
B:
[21-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
---
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
218
Blastp_CBE
70.16
42%
-137
- C5 -
-
2G2F
1
ABL1_HUMAN
A:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
171
Blastp_CBE
70.09
42%
-143
- C5 -
-
3MSS
2
ABL1_MOUSE
C:
[21-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
317
Blastp_CBE
70.07
37%
-168
- C5 -
-
4I4F
2
A:
[10-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
Q
R
E
------
R
I
E
--
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
---
I
Y
----
M
S
------------
P
A
L
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
--
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
-
H
P
H
I
V
K
L
I
G
V
I
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------------------------
Y
S
----
L
D
--
L
A
-----
S
L
I
L
Y
A
---
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
---
S
N
D
C
----
V
K
L
G
D
F
G
L
S
-------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
L
----------------------------------------------------------------------------------------------------
247
Blastp_CBE
70.03
42%
-163
- C5 -
-
3CS9
1
ABL1_HUMAN
B:
[20-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
252
Blastp_CBE
70.02
42%
-145
- C5 -
-
3QRI
1
ABL1_HUMAN
B:
[21-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
--------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
183
Blastp_CBE
69.99
42%
-135
- C5 -
-
1IEP
1
ABL1_MOUSE
B:
[21-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
210
Blastp_CBE
69.93
42%
-139
- C5 -
-
3QRJ
1
ABL1_HUMAN
B:
[21-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------------------
259
Blastp_CBE
69.90
42%
-166
- C5 -
-
5MO4
2
ABL1_HUMAN
A:
[223-482]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
-----
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
N
------------
R
Q
-----
E
----------
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
-----------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
257
Blastp_CBE
69.88
42%
-143
- C5 -
-
4XEY
1
ABL1_HUMAN
A:
[128-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
----
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
175
Blastp_CBE
69.86
42%
-140
- C5 -
-
3MS9
2
ABL1_MOUSE
A:
[21-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
--
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
245
Blastp_CBE
69.84
42%
-140
- C5 -
-
3CS9
1
ABL1_HUMAN
D:
[20-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
---------------------
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
173
Blastp_CBE
69.74
42%
-141
- C5 -
-
3MSS
2
ABL1_MOUSE
A:
[21-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
184
Blastp_CBE
69.71
42%
-139
- C5 -
-
1IEP
1
ABL1_MOUSE
A:
[21-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
186
Blastp_CBE
69.67
42%
-130
- C5 -
-
1FPU
1
ABL1_MOUSE
A:
[21-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
233
Blastp_CBE
69.62
42%
-137
- C5 -
-
5HU9
13
ABL1_HUMAN
A:
[20-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
-------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
195
Blastp_CBE
69.60
42%
-138
- C5 -
-
2E2B
1
ABL1_HUMAN
A:
[21-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
----
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
202
Blastp_CBE
69.55
42%
-153
- C5 -
-
4YC8
3
ABL1_HUMAN
B:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
------
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
246
Blastp_CBE
69.46
42%
-157
- C5 -
-
3CS9
1
ABL1_HUMAN
C:
[20-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
--------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
-----------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------------------
219
Blastp_CBE
69.42
42%
-156
- C5 -
-
6NPV
5
ABL1_HUMAN
B:
[29-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
--------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
214
Blastp_CBE
69.36
42%
-140
- C5 -
-
2G2I
1
ABL1_HUMAN
A:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
---
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
223
Blastp_CBE
69.26
42%
-157
- C5 -
-
6NPE
3
ABL1_HUMAN
B:
[29-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
205
Blastp_CBE
69.25
42%
-134
- C5 -
-
3UE4
1
ABL1_HUMAN
A:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
200
Blastp_CBE
69.20
42%
-132
- C5 -
-
2HIW
1
ABL1_HUMAN
B:
[18-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
108
Blastp_CBE
69.17
40%
-176
- C5 -
-
5HNI
1
MET_HUMAN
X:
[15-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
------------------------
G
C
V
Y
H
G
---
T
L
-------------------
K
I
H
C
A
V
K
S
----------
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
--------------------
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
166
Blastp_CBE
69.15
42%
-141
- C5 -
-
6HD6
1
ABL1_MOUSE
B:
[21-280]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
---
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
97
Blastp_CBE
69.08
42%
-39
- C5 -
-
3PLS
1
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
A
L
L
A
E
V
K
D
V
L
I
P
H
E
------
R
V
V
--
T
HS
D
R
V
I
G
K
G
H
F
G
V
V
Y
H
G
---
E
Y
----
I
D
--
Q
A
----
Q
---
N
R
I
Q
C
A
I
K
S
L
-
S
R
I
T
E
M
Q
Q
V
E
--
A
F
L
R
E
G
L
L
M
R
G
L
-
N
-
H
P
N
V
L
A
L
I
G
I
M
L
P
P
E
G
-----
L
P
H
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
R
S
P
Q
-------------------
R
--
N
P
-------
T
--
V
K
-----
D
L
I
S
F
G
---
L
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
S
F
T
----
V
K
V
A
D
F
G
L
A
R
D
I
L
D
R
E
Y
--
Y
SV
Q
Q
H
R
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
-
G
A
P
P
Y
R
H
I
D
P
F
D
L
T
H
F
L
A
Q
-------
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
----
R
V
L
V
G
E
V
E
Q
I
V
S
A
L
-------------------------------------------------------------------------------------------------
255
Blastp_CBE
69.07
42%
-128
- C5 -
-
2HZ0
1
ABL1_HUMAN
A:
[16-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------------------
107
Blastp_CBE
69.00
40%
-175
- C5 -
-
5HNI
1
Y:
[15-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
------------------------
G
C
V
Y
H
G
---
T
L
-------------------
K
I
H
C
A
V
K
S
----------
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
--------------------
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
113
Blastp_CBE
68.89
40%
-169
- C5 -
-
5HOR
1
A:
[16-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
------------------------
G
C
V
Y
H
G
---
T
L
-------------------
K
I
H
C
A
V
K
S
----------
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
-----------------
L
P
V
K
W
T
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
213
Blastp_CBE
68.75
42%
-139
- C5 -
-
2G2I
1
ABL1_HUMAN
B:
[18-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
----
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
-------------------------------------------------------------------------------------------------
225
Blastp_CBE
68.67
42%
-155
- C5 -
-
3PYY
3
ABL1_HUMAN
B:
[29-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
--------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
227
Blastp_CBE
68.62
42%
-144
- C5 -
-
6BL8
1
ABL1_HUMAN
B:
[11-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
---
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
F
--
T
A
H
-
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
235
Blastp_CBE
68.51
42%
-150
- C5 -
-
2HZ4
1
ABL1_HUMAN
B:
[16-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
-----
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------------------
256
Blastp_CBE
68.48
42%
-149
- C5 -
-
4XEY
1
ABL1_HUMAN
B:
[128-387]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
------
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
203
Blastp_CBE
68.45
42%
-153
- C5 -
-
4YC8
3
ABL1_HUMAN
A:
[18-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
------
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------------------
178
Blastp_CBE
68.42
42%
-134
- C5 -
-
2HZN
1
ABL1_MOUSE
A:
[21-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
---
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
--
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------------------
221
Blastp_CBE
68.15
42%
-158
- C5 -
-
6NPU
5
ABL1_HUMAN
B:
[29-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
---------
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
--------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
217
Blastp_CBE
67.86
42%
-138
- C5 -
-
2G2F
1
ABL1_HUMAN
B:
[18-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
-----
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
194
Blastp_CBE
67.83
42%
-138
- C5 -
-
2E2B
1
ABL1_HUMAN
B:
[21-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
--------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
-------
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------------------
54
Blastp_CBE
67.73
41%
-46
- C5 -
-
3RHK
1
MET_HUMAN
A:
[25-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
229
Blastp_CBE
67.68
41%
-142
- C5 -
-
4UEU
1
?
A:
[8-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
S
------
E
I
T
--
L
--
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
---
K
W
----
R
N
--
Y
N
----------
I
E
V
A
V
K
T
L
K
E
G
T
M
S
---
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
------
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
---
R
------------
D
C
-----
E
--
G
-
H
T
----
V
N
--
A
Q
-----
A
L
L
D
M
A
---
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
N
V
----
V
K
V
A
D
F
G
L
A
R
L
I
---------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
-------
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
----
A
E
T
L
H
A
L
E
T
M
F
----------------------------------------------------------------------------------------------------
230
Blastp_CBE
67.43
41%
-150
- C5 -
-
4CSV
1
?
A:
[8-268]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
R
S
------
E
I
T
--
L
--
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
---
K
W
----
R
N
--
Y
N
----------
I
E
V
A
V
K
T
L
K
E
G
T
M
S
---
V
E
--
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
-
H
P
N
L
V
Q
L
Y
G
V
C
T
K
E
------
P
P
I
Y
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
---
R
------------
D
C
----------------
V
N
--
A
Q
-----
A
L
L
D
M
A
---
A
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
N
V
----
V
K
V
A
D
F
G
----------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
-------
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
----
A
E
T
L
H
A
L
E
T
M
F
----------------------------------------------------------------------------------------------------
71
Blastp_CBE
67.35
41%
-36
- C5 -
-
5EOB
1
A:
[28-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV---
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
41
Blastp_CBE
67.35
41%
-50
- C5 -
-
5EYD
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
-------------------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
--
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
53
Blastp_CBE
67.33
41%
-39
- C5 -
-
3RHK
1
B:
[25-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
42
Blastp_CBE
67.22
41%
-47
- C5 -
-
5EYC
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
--------------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
111
Blastp_CBE
67.18
40%
-40
- C5 -
-
3DKC
1
A:
[8-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
DS
V
--
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
106
Blastp_CBE
66.99
40%
-173
- C5 -
-
5HO6
1
A:
[15-296]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
-------------------------
C
V
Y
H
G
---
T
L
--------------------
I
H
C
A
V
K
S
----------
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
----
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
-------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
44
Blastp_CBE
66.97
41%
-51
- C5 -
-
4XMO
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
-------------------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
51
Blastp_CBE
66.81
41%
-42
- C5 -
-
5DG5
1
B:
[25-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
72
Blastp_CBE
66.79
41%
-43
- C5 -
-
4MXC
1
A:
[26-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV-----
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
43
Blastp_CBE
66.77
41%
-44
- C5 -
-
4XYF
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
--------------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
46
Blastp_CBE
66.72
41%
-48
- C5 -
-
4DEH
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
-------------------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
--
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
86
Blastp_CBE
66.56
42%
-38
- C5 -
-
2WD1
3
A:
[7-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
84
Blastp_CBE
66.49
41%
-37
- C5 -
-
2WGJ
1
A:
[4-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
-------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
81
Blastp_CBE
66.43
41%
-41
- C5 -
-
3ZC5
1
A:
[4-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
-------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
422
Blastp_CBE
66.41
37%
-91
- C5 -
-
3L9P
4
A:
[68-351]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
----
S
G
------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
--
Y
--
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
87
Blastp_CBE
66.36
42%
-37
- C5 -
-
4R1V
4
A:
[7-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
--
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
47
Blastp_CBE
66.35
41%
-47
- C5 -
-
4DEG
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
-------------------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
52
Blastp_CBE
66.34
41%
-43
- C5 -
-
5DG5
1
MET_HUMAN
A:
[25-316]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
109
Blastp_CBE
66.31
40%
-35
- C5 -
-
1R0P
1
A:
[5-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
-------------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
DS
V
--
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
------
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
67
Blastp_CBE
66.24
41%
-49
- C5 -
-
6SDD
2
A:
[25-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
--
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
--------
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
V
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
199
Blastp_CBE
66.19
42%
-142
- C5 -
-
4WA9
1
ABL1_HUMAN
A:
[17-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
-------------------------
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
---
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
562
HHSearch
66.18
35%
-128
- C5 -
-
6BRJ
1
DDR1_HUMAN
A:
[568-873]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
S
------
R
L
R
--
F
--
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
---
E
V
--------------------
L
L
V
A
V
K
I
L
R
P
D
A
-
T
K
N
A
R
N
--
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
------
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
------------
L
E
-----
D
----
P
T
----
I
S
--
Y
P
-----
M
L
L
H
V
A
---
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
---
E
N
F
T
----
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
--
Y
--
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
FFRDQGR
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
----
S
Q
L
H
R
F
L
A
E
D
A
L
---------------------------------------------------------------------------------------------------
66
Blastp_CBE
66.17
41%
-43
- C5 -
-
3F66
4
MET_HUMAN
A:
[2-293]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
--------------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV-----
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
68
Blastp_CBE
66.09
41%
-48
- C5 -
-
6SDC
1
A:
[16-307]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
----
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
----
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
V
M
Y
D
K
E
Y
--
Y
SV-----
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
78
Blastp_CBE
65.89
41%
-30
- C5 -
-
3ZZE
1
A:
[10-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
397
Blastp_CBE
65.84
37%
-100
- C5 -
-
4CMU
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
254
Blastp_CBE
65.81
42%
-159
- C5 -
-
2HZ0
1
ABL1_HUMAN
B:
[16-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
------
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
----------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------------------
83
Blastp_CBE
65.52
41%
-35
- C5 -
-
2WKM
1
A:
[10-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
45
Blastp_CBE
65.50
41%
-38
- C5 -
-
4DEI
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
-------------
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
79
Blastp_CBE
65.48
41%
-38
- C5 -
-
3ZXZ
1
A:
[4-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
-------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
80
Blastp_CBE
65.46
41%
-39
- C5 -
-
3ZCL
1
A:
[4-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
-------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
70
Blastp_CBE
65.46
41%
-41
- C5 -
-
5HTI
1
A:
[26-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV-----
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
77
Blastp_CBE
65.42
41%
-37
- C5 -
-
4AOI
1
A:
[4-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
-------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
295
Blastp_CBE
65.38
37%
-98
- C5 -
-
5AA9
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
399
Blastp_CBE
65.24
37%
-96
- C5 -
-
4CMO
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
296
Blastp_CBE
65.23
37%
-97
- C5 -
-
5AAB
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
--
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
Y
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
297
Blastp_CBE
65.17
37%
-97
- C5 -
-
5AA8
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
Y
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
294
Blastp_CBE
65.17
37%
-97
- C5 -
-
5AAA
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
394
Blastp_CBE
65.14
37%
-98
- C5 -
-
4CTB
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
---
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
50
Blastp_CBE
65.14
41%
-43
- C5 -
-
3I5N
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
------
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
-----
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
60
Blastp_CBE
65.11
41%
-40
- C5 -
-
3CD8
1
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
-------------------
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
-----
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
-
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
280
Blastp_CBE
65.07
42%
-113
- C5 -
-
2GQG
2
ABL1_HUMAN
B:
[21-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
T
--
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
377
Blastp_CBE
65.00
37%
-97
- C5 -
-
5FTQ
2
A:
[19-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
-
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
406
Blastp_CBE
64.93
37%
-94
- C5 -
-
4FOD
2
A:
[34-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
----
S
-------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
400
Blastp_CBE
64.90
37%
-96
- C5 -
-
4CLI
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
392
Blastp_CBE
64.86
37%
-97
- C5 -
-
5A9U
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
Y
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
418
Blastp_CBE
64.78
37%
-95
- C5 -
-
4FOC
1
A:
[54-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
----
S
-------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
---
T
CPG
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
421
Blastp_CBE
64.72
37%
-92
- C5 -
-
4MKC
3
A:
[68-351]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
----
S
-------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
--
Y
--
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
82
Blastp_CBE
64.71
41%
-32
- C5 -
-
3ZBX
1
A:
[10-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
-------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
413
Blastp_CBE
64.68
36%
-96
- C5 -
-
4CLJ
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
401
Blastp_CBE
64.68
37%
-98
- C5 -
-
4CCU
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
391
Blastp_CBE
64.63
37%
-97
- C5 -
-
5AAC
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
Y
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
502
Blastp_CBE
64.62
37%
-105
- C5 -
-
2J0L
1
A:
[4-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
Q
R
E
------
R
I
E
--
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
---
I
Y
----
M
S
--
P
E
----
N
---
P
A
M
A
V
A
I
K
T
C
K
-
N
C
T
S
D
S
V
R
E
--
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
-
H
P
H
I
V
K
L
I
G
V
I
T
E
N
------
P
V
-
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
Q
V
R
K
------------------------
F
S
----
L
D
--
L
A
-----
S
L
I
L
Y
A
---
Y
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
---
S
---
S
N
D
C
----
V
K
L
G
D
F
G
L
S
R
Y
M
E
D
S
T
K
--
A
--
S
K
G
---
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
----
T
E
L
K
A
Q
L
S
T
I
L
E
E
--------------------------------------------------------------------------------------------------
395
Blastp_CBE
64.53
37%
-81
- C5 -
-
4CNH
2
B:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
---------
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
Y
---------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
398
Blastp_CBE
64.49
37%
-98
- C5 -
-
4CMT
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
---------
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
389
Blastp_CBE
64.37
37%
-94
- C5 -
-
5KZ0
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
393
Blastp_CBE
64.36
37%
-97
- C5 -
-
4CTC
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
----
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
76
Blastp_CBE
64.35
41%
-36
- C5 -
-
4AP7
1
A:
[4-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
-------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
61
Blastp_CBE
64.34
41%
-44
- C5 -
-
3CCN
1
A:
[9-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
-------------------
K
I
H
C
A
V
K
S
L
N
R
------
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
-
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
412
Blastp_CBE
64.31
37%
-94
- C5 -
-
3AOX
5
A:
[44-327]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
----
G
E
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
420
Blastp_CBE
64.28
36%
-94
- C5 -
-
4CD0
1
A:
[42-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
266
Blastp_CBE
64.24
42%
-110
- C5 -
-
2V7A
1
ABL1_HUMAN
B:
[17-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
T
--
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
75
Blastp_CBE
64.02
41%
-41
- C5 -
-
5UAD
1
A:
[12-327]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
---------------------
H
C
A
V
K
S
L
N
-----
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
375
Blastp_CBE
63.99
37%
-102
- C5 -
-
6MX8
1
A:
[18-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P--------
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
-----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
73
Blastp_CBE
63.94
41%
-38
- C5 -
-
4GG7
1
A:
[37-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
376
Blastp_CBE
63.91
37%
-98
- C5 -
-
4ANQ
1
A:
[42-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
405
Blastp_CBE
63.89
37%
-98
- C5 -
-
4ANS
1
A:
[42-325]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
3
PsiBlast_PDB
63.83
97%
-187
- C5 -
-
4FF8
1
A:
[80-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
-
D
-
H
P
H
V
A
K
L
-----------------
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
L
A
S
R
------------
I
------------------
P
--
L
Q
-----
T
L
V
R
F
M
---
V
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
---
A
---
E
D
M
T
----
V
C
V
A
---------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
-
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
--
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
----
T
C
L
R
M
E
L
E
N
I
L
----------------------------------------------------------------------------------------------------
402
Blastp_CBE
63.80
37%
-97
- C5 -
-
4CCB
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
---------
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
85
Blastp_CBE
63.70
42%
-45
- C5 -
-
4R1Y
3
A:
[8-290]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
---------------
I
H
C
A
V
K
S
L
N
---------
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
63.70
41%
-45
- C5 -
-
5UAB
2
A:
[12-327]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
---------------------
H
C
A
V
K
S
L
N
--------
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
74
Blastp_CBE
63.65
41%
-45
- C5 -
-
4GG5
1
A:
[37-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
------
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
69
Blastp_CBE
63.65
41%
-41
- C5 -
-
5YA5
1
A:
[30-317]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
-------------
K
K
I
H
C
A
V
K
S
L
N
R
--------
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
-----
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
381
Blastp_CBE
63.58
37%
-100
- C5 -
-
6EDL
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
V
----
S
-------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
--------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
88
Blastp_CBE
63.57
41%
-30
- C5 -
-
3LQ8
1
A:
[5-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
--
D
K
E
Y
--
Y
S------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
281
Blastp_CBE
63.56
42%
-112
- C5 -
-
2GQG
2
ABL1_HUMAN
A:
[21-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
T
--
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------------------
59
Blastp_CBE
63.54
41%
-22
- C5 -
-
3EFJ
1
MET_HUMAN
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
262
Blastp_CBE
63.51
42%
-115
- C5 -
-
3DK7
1
ABL1_MOUSE
A:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
-------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
T
--
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
380
Blastp_CBE
63.46
37%
-92
- C5 -
-
2XB7
1
A:
[19-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
------------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
419
Blastp_CBE
63.44
37%
-91
- C5 -
-
4FOB
1
A:
[54-337]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
----
S
-------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
---------
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
---
T
CPG
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
----------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
383
Blastp_CBE
63.42
37%
-96
- C5 -
-
6E0R
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
----
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
---------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
414
Blastp_CBE
63.36
36%
-96
- C5 -
-
2YFX
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
58
Blastp_CBE
63.34
41%
-16
- C5 -
-
3EFJ
1
B:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
-------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
63.32
41%
-30
- C5 -
-
3VW8
1
A:
[32-320]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
-----
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
404
Blastp_CBE
63.30
37%
-88
- C5 -
-
4TT7
5
A:
[18-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
----
G
E
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
---------
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
------
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
90
Blastp_CBE
63.29
42%
-41
- C5 -
-
4KNB
2
MET_HUMAN
C:
[2-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
--------------------
I
H
C
A
V
K
S
L
N
R
----
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
---------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
545
Blastp_CBE
63.18
39%
-12
- C5 -
-
4QRC
1
A:
[32-320]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
---
E
A
----
F
G
--
M
D
PARP
D
---
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
--
D
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
---
E
G
P
L
---
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
PPGPDLSPDGPR
S
S
-----
E
--
G
P
L
S
----
F
P
--
V
-------
L
V
S
C
A
---
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
--
Y
--
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
E
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
----
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------
92
Blastp_CBE
63.18
42%
-44
- C5 -
-
4KNB
3
MET_HUMAN
A:
[5-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
--------------
K
I
H
C
A
V
K
S
L
----
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
110
Blastp_CBE
63.10
40%
-20
- C5 -
-
3DKF
1
A:
[8-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
------------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
---------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
408
Blastp_CBE
63.00
37%
-93
- C5 -
-
4DCE
1
ALK_HUMAN
A:
[34-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
V
----
S
---------
P
---
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
390
Blastp_CBE
62.98
37%
-93
- C5 -
-
5IMX
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
----------
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
--------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
403
Blastp_CBE
62.97
37%
-94
- C5 -
-
2XP2
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
---
Q
V
-------------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
---------
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
410
Blastp_CBE
62.90
37%
-37
- C5 -
-
3LCT
3
A:
[45-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
----
S
G
MP
N
D
----
P
---
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
--
Y
--
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
63
Blastp_CBE
62.90
41%
-22
- C5 -
-
2RFN
1
B:
[10-298]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
----
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
-------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
48
Blastp_CBE
62.89
41%
-21
- C5 -
-
3U6I
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
379
Blastp_CBE
62.88
37%
-98
- C5 -
-
2XBA
1
A:
[19-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
-------
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
--------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
264
Blastp_CBE
62.87
42%
-119
- C5 -
-
3DK6
1
ABL1_MOUSE
A:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
--
G
Q
F
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
--------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
T
--
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
396
Blastp_CBE
62.81
37%
-96
- C5 -
-
4CNH
1
ALK_HUMAN
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
------
E
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
55
Blastp_CBE
62.70
41%
-26
- C5 -
-
4EEV
1
A:
[24-315]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
---------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
417
Blastp_CBE
62.66
37%
-92
- C5 -
-
4Z55
3
A:
[40-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
------------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P---------------
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
--
Y
---
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
96
Blastp_CBE
62.65
42%
-28
- C5 -
-
5HLW
1
A:
[5-288]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
V
Q
A
V
Q
H
V
V
I
G
-
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
-
H
F
G
C
V
Y
H
G
---
T
L
----
L
----
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
-
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
-----
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
H
D
K
E
Y
--
Y
SV-----
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
114
Blastp_CBE
62.62
40%
-167
- C5 -
-
5HOA
1
A:
[17-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
Q
H
V
V
-----------------------------
V
Y
H
G
---
T
L
-------------------
K
I
H
C
A
V
K
---------------
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
----------------
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
V
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
-------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
64
Blastp_CBE
62.57
41%
-19
- C5 -
-
2RFN
1
MET_HUMAN
A:
[11-298]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
----
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
-------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
56
Blastp_CBE
62.57
41%
-18
- C5 -
-
3EFK
1
B:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
563
HHSearch
62.50
35%
-77
- C5 -
-
6BSD
1
DDR1_HUMAN
A:
[567-873]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
P
R
S
------
R
L
R
--
F
--
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
---
E
V
----
D
S
-------------
P
L
L
V
A
V
K
I
L
R
P
D
A
-
T
K
N
A
R
N
--
D
F
L
K
E
V
K
I
M
S
R
L
-
K
-
D
P
N
I
I
R
L
L
G
V
C
V
Q
D
D
------
P
L
C
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
S
A
H
Q
------------
L
E
-----
D
KA-
G
P
T
----
I
S
--
Y
P
-----
M
L
L
H
V
A
---
A
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
---
G
---
E
N
F
T
----
I
K
I
A
D
F
G
--
R
N
L
Y
A
G
D
Y
--
Y
--
R
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
FFRDQGR
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
----
S
Q
L
H
R
F
L
A
E
D
A
L
---------------------------------------------------------------------------------------------------
568
HHSearch
62.41
40%
-15
- C5 -
-
5A46
2
B:
[33-326]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
R
W
E
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
---
E
A
----
I
G
--
L
-DKP-
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
G
------
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
------------
P
P
------HN
P
E
E
Q
----
L
S
--
S
K
-----
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
49
Blastp_CBE
62.37
41%
-24
- C5 -
-
3U6H
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
-----------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
65
Blastp_CBE
62.36
41%
-27
- C5 -
-
3F66
3
B:
[11-293]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
-------------
K
K
I
H
C
A
V
K
S
L
N
-------
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
---
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
62
Blastp_CBE
62.31
41%
-47
- C5 -
-
2RFS
1
A:
[21-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
-------------------
K
I
H
C
A
V
K
S
L
N
-----
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
261
Blastp_CBE
62.29
42%
-112
- C5 -
-
3DK7
1
ABL1_MOUSE
B:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
----
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
T
--
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
57
Blastp_CBE
62.28
41%
-14
- C5 -
-
3EFK
1
MET_HUMAN
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
535
Blastp_CBE
62.18
39%
-23
- C5 -
-
4UXQ
1
A:
[18-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
R
A
---
E
A
----
F
G
--
M
D
PARP
D
---
Q
A
S
T
V
A
V
K
M
L
K
-
D
N
A
S
D
K
D
L
A
--
D
L
V
S
E
M
E
V
M
K
L
I
-
G
R
H
K
N
I
I
N
L
L
G
V
C
T
Q
---
E
G
P
L
---
Y
V
I
V
E
C
A
A
K
G
N
L
R
E
F
L
R
A
R
R
PP--------------------
G
P
L
S
----
F
P
--
V
-------
L
V
S
C
A
---
Y
Q
V
A
R
G
M
Q
Y
L
E
S
R
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
G
V
H
H
I
D
Y
--
Y
--
K
K
T
S
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
I
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
S
L
L
R
E
-------
G
H
R
M
D
R
P
P
H
C
P
P
E
L
Y
G
L
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
----
K
Q
L
V
E
A
L
D
K
V
L
L
A
V
-------------------------------------------------------------------------------------------------
267
Blastp_CBE
62.11
42%
-108
- C5 -
-
2V7A
1
ABL1_HUMAN
A:
[17-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
N
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
T
--
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
134
Blastp_CBE
61.92
41%
-30
- C5 -
-
5HHW
2
?
A:
[15-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
39
Blastp_CBE
61.86
41%
-32
- C5 -
-
6SD9
1
MET_HUMAN
A:
[25-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
------
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
-----
E
Y
--
Y
S----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
388
Blastp_CBE
61.84
37%
-94
- C5 -
-
4FNZ
1
A:
[28-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
V
----
S
G
------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
-------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
147
Blastp_CBE
61.83
39%
-24
- C5 -
-
3QQU
1
IGF1R_HUMAN
C:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------
M
-----------
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
146
Blastp_CBE
61.80
39%
-24
- C5 -
-
3QQU
1
D:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------
M
------------
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
382
Blastp_CBE
61.67
37%
-89
- C5 -
-
6EBW
1
A:
[27-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
--
F
G
E
V
Y
E
G
---
Q
V
----
S
-------------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P--------
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
------------------
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
40
Blastp_CBE
61.61
41%
-29
- C5 -
-
5T3Q
1
?
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
--
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
148
Blastp_CBE
61.59
39%
-24
- C5 -
-
3QQU
1
IGF1R_HUMAN
B:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
--------------------------------PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
104
Blastp_CBE
61.43
40%
-18
- C5 -
-
3CTH
1
A:
[7-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
38
Blastp_CBE
61.42
41%
-37
- C5 -
-
6SDE
1
A:
[31-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
--------------
K
I
H
C
A
V
K
S
L
N
R
-
I
----
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
--
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
115
Blastp_CBE
61.22
40%
-25
- C5 -
-
3DKG
1
A:
[8-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
------
C
V
Y
H
G
---
T
L
----
L
D
------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
-------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
423
Blastp_CBE
61.15
36%
-99
- C5 -
-
4FNY
1
A:
[28-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
V
----
S
G
-------------
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----------
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
--------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
516
Blastp_CBE
61.10
39%
-5
- C5 -
-
3C4F
1
B:
[10-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P------------------------------
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
153
Blastp_CBE
60.99
40%
-24
- C5 -
-
3EKN
1
A:
[15-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
---
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
438
Blastp_CBE
60.97
39%
2
- C5 -
-
4UWC
9
FGFR1_HUMAN
A:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PPGLE-------
Y
S
-----
Y
---
P
S
H
----
N
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
263
Blastp_CBE
60.95
42%
-118
- C5 -
-
3DK6
1
ABL1_MOUSE
B:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
--
M
--
K
H
K
-------
E
V
Y
E
G
---
V
W
----
K
K
--
Y
S
----------
L
T
V
A
V
K
T
L
--------
E
V
E
--
E
F
L
K
E
A
A
V
M
K
E
I
-
K
-
H
P
N
L
V
Q
L
L
G
V
C
T
R
E
------
P
P
F
Y
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
R
E
C
-----------------------
N
R
Q
E
----
V
S
--
A
V
-----
V
L
L
Y
M
A
---
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
---
G
---
E
N
H
L
----
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
T
--
A
H
A
G
A
-
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
----
A
E
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------------------
517
Blastp_CBE
60.93
39%
-9
- C5 -
-
3C4F
1
FGFR1_HUMAN
A:
[10-299]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P------------------------------
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
99
Blastp_CBE
60.90
40%
-19
- C5 -
-
3QTI
1
MET_HUMAN
A:
[7-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
-------------
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
---
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
101
Blastp_CBE
60.85
40%
-15
- C5 -
-
3L8V
1
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
450
Blastp_CBE
60.80
39%
-19
- C5 -
-
4F64
3
FGFR1_HUMAN
A:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
-----
G
Q
V
V
L
A
---
E
A
IGL------
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P------------------------------
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
105
Blastp_CBE
60.79
40%
-22
- C5 -
-
3CE3
1
A:
[8-298]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
----------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
102
Blastp_CBE
60.77
40%
-28
- C5 -
-
3F82
1
A:
[9-298]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
--------------
K
I
H
C
A
V
K
S
L
N
R
-----
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
---------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
440
Blastp_CBE
60.75
39%
6
- C5 -
-
4UWB
4
FGFR1_HUMAN
A:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PPGLE-------
Y
S
---------
P
S
H
----
N
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
119
Blastp_CBE
60.74
38%
13
- C5 -
-
3I81
1
A:
[6-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
T
------
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE-----------
E
-----
N
--
N
P
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-----
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
K
----------------------------------------------------------------------------------------
456
Blastp_CBE
60.71
39%
-18
- C5 -
-
5Z0S
1
FGFR1_HUMAN
A:
[16-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGL--
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P------------------------------
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
117
Blastp_CBE
60.73
41%
-21
- C5 -
-
3ETA
1
INSR_HUMAN
A:
[13-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
-
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
455
Blastp_CBE
60.71
39%
-21
- C5 -
-
5Z0S
1
B:
[16-304]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGL------
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P------------------------------
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------
244
Blastp_CBE
60.67
40%
-15
- C5 -
-
2IVS
5
RET_HUMAN
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-----------
V
G
PGYL--------RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
Y
--
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
142
Blastp_CBE
60.66
39%
7
- C5 -
-
3NW6
1
A:
[7-306]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------
M
E
-----
N
--
N
P
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
112
Blastp_CBE
60.65
40%
-23
- C5 -
-
3C1X
1
A:
[66-357]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
-----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
140
Blastp_CBE
60.56
41%
-19
- C5 -
-
4IBM
1
?
A:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
426
Blastp_CBE
60.50
39%
-19
- C5 -
-
5O4A
2
FGFR1_HUMAN
A:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PPG-------------------------------
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
550
Blastp_CBE
60.46
38%
-5
- C5 -
-
5A46
2
B:
[37-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
---
E
A
IGL--
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PP-----------------------
H
----
N
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
----
L
T
S
N
Q
E
-----------------------------------------------------------------------------------------
411
Blastp_CBE
60.46
37%
-38
- C5 -
-
3LCS
3
A:
[45-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
----
S
G
MP
N
D
----
P
---
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
--
Y
--
R
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
442
Blastp_CBE
60.43
39%
-28
- C5 -
-
4NKS
1
FGFR1_HUMAN
A:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
-----
G
Q
V
V
L
A
---
E
A
I-------------
N
---
R
V
T
K
V
A
V
K
M
L
K
-
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PP----------------------------------QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
------
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
431
Blastp_CBE
60.38
39%
-6
- C5 -
-
4V05
3
B:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD-----
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PP---------------------------------
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
----
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
260
Blastp_CBE
60.39
38%
-24
- C5 -
-
3D94
1
A:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
--------------------------------PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
94
Blastp_CBE
60.38
41%
-44
- C5 -
-
3Q6W
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
S
--
V
--
H
N
K
T
----
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
149
Blastp_CBE
60.36
39%
-25
- C5 -
-
3QQU
1
IGF1R_HUMAN
A:
[9-300]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
-------------------------------
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
151
Blastp_CBE
60.33
39%
17
- C5 -
-
5FXS
1
A:
[7-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------
M
E
-----
N
--
N
P
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
A
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
E
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
549
Blastp_CBE
60.18
39%
-5
- C5 -
-
4K33
1
A:
[37-318]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
T
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
A
IGID
K
D
--
R
A
----
A
---
K
P
V
T
V
A
V
K
M
L
K
D
D
A
-
T
D
K
D
L
S
--
D
L
V
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
G
---
G
P
L
---
Y
V
L
V
E
Y
A
A
K
G
N
L
R
E
F
L
R
A
R
R
------------
P
P
GL---
D
--
Y
S
F
D
TSEQ
L
T
--
F
K
-----
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
V
H
N
L
D
Y
--
Y
--
K
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
H
D
L
Y
M
I
M
R
E
C
W
H
A
A
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
V
L
----------------------------------------------------------------------------------------------------
130
Blastp_CBE
60.09
39%
8
- C5 -
-
3LW0
4
IGF1R_HUMAN
B:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P------------------------------
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
409
Blastp_CBE
59.94
37%
-108
- C5 -
-
4JOA
1
A:
[45-328]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
------
V
Y
E
G
---
Q
V
----
S
---------------
L
Q
V
A
V
K
T
L
-
P
-----------
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
----------------
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
--------------
A
M
L
P
V
K
W
M
P
P
E
A
---
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
532
Blastp_CBE
59.84
38%
-12
- C5 -
-
3GQL
1
FGFR1_HUMAN
A:
[25-323]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PP---------------------------------
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
----------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
----
L
T
S
N
Q
E
Y
L
D
L
S
M
-----------------------------------------------------------------------------------
437
Blastp_CBE
59.84
39%
2
- C5 -
-
4UWC
9
B:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGL--
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PPGLE-------
Y
S
-----
Y
-----
H
----
N
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
542
Blastp_CBE
59.83
39%
8
- C5 -
-
5VND
10
FGFR1_HUMAN
A:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PPGLE-------
Y
S
-----
Y
--
N
P
S
H
----
N
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
378
Blastp_CBE
59.78
37%
-36
- C5 -
-
5FTO
1
A:
[19-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
P
R
K
------
N
I
T
--
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
V
----
S
G
M-----------
S
P
L
Q
V
A
V
K
T
L
-
P
E
V
C
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
-
H
Q
N
I
V
R
C
I
G
V
S
L
Q
S
L
P
R
------
F
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
R
E
T
R
------------
P
R
P----
S
--
Q
P
S
S
----
L
A
--
M
L
-----
D
L
L
H
V
A
---
R
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
TCP
G
---
P
G
R
V
----
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-----------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
----
A
I
I
L
E
R
I
E
---------
Y
C
T
Q
D
P
D
V
I
N
------------------------------------------------------------------------------------
242
Blastp_CBE
59.75
40%
-5
- C5 -
-
6NEC
3
RET_HUMAN
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-----------
V
G
PGYLG-----
D
E
RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
Y
--
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
143
Blastp_CBE
59.67
39%
11
- C5 -
-
3NW5
1
A:
[6-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------
M
E
-----
N
--
N
P
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
141
Blastp_CBE
59.65
39%
10
- C5 -
-
3NW7
1
A:
[8-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------
M
E
-----
N
--
N
P
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
129
Blastp_CBE
59.57
39%
7
- C5 -
-
3LW0
4
IGF1R_HUMAN
C:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P------------------------------
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
139
Blastp_CBE
59.49
41%
-16
- C5 -
-
4IBM
1
?
B:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
---
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
133
Blastp_CBE
59.45
41%
-36
- C5 -
-
5E1S
1
A:
[16-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
---------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
439
Blastp_CBE
59.40
39%
1
- C5 -
-
4UWB
3
B:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGL--
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PPGLE-------
Y
S
-----
Y
-----
H
----
N
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
91
Blastp_CBE
59.35
42%
-47
- C5 -
-
4KNB
2
MET_HUMAN
B:
[8-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
--------------
K
I
H
C
A
V
K
S
-------
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
-----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV-------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
128
Blastp_CBE
59.32
39%
8
- C5 -
-
3LW0
3
D:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P------------------------------
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
454
Blastp_CBE
59.31
39%
-8
- C5 -
-
6ITJ
1
?
A:
[16-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P------------------------------
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
93
Blastp_CBE
59.28
41%
-41
- C5 -
-
3R7O
1
A:
[6-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
S
--
V
--
H
N
K
T
----
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
131
Blastp_CBE
59.17
39%
6
- C5 -
-
3LW0
3
IGF1R_HUMAN
A:
[3-303]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P------------------------------
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
98
Blastp_CBE
59.06
40%
-28
- C5 -
-
3QTI
2
B:
[12-298]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
-------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
----------
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
----
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
152
Blastp_CBE
59.03
41%
-29
- C5 -
-
1I44
1
A:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
--------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
155
Blastp_CBE
58.99
39%
3
- C5 -
-
3LVP
2
D:
[36-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
----------
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------------------
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
558
HHSearch
58.94
41%
-12
- C5 -
-
5FM3
1
A:
[59-353]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
---
T
A
----
F
H
--
L
K
GR--
A
---
G
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
G
------
P
L
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
--------------------------
A
----
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
Y
--
V
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
V
K
--------------------------------------------------------------------------------------------------
157
Blastp_CBE
58.82
39%
9
- C5 -
-
3LVP
1
IGF1R_HUMAN
B:
[36-335]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------------------
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
116
Blastp_CBE
58.82
41%
-20
- C5 -
-
3ETA
1
B:
[13-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
138
Blastp_CBE
58.79
39%
16
- C5 -
-
1JQH
1
IGF1R_HUMAN
A:
[7-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------------------
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
-------
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
538
Blastp_CBE
58.77
39%
8
- C5 -
-
6P68
1
C:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P------------------------------
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
539
Blastp_CBE
58.74
39%
-3
- C5 -
-
6P68
1
FGFR1_HUMAN
B:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-------------------------------
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
100
Blastp_CBE
58.73
40%
-17
- C5 -
-
3A4P
3
A:
[22-303]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
------------
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
------------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
103
Blastp_CBE
58.71
40%
-22
- C5 -
-
3CTJ
1
A:
[7-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
-----------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
490
Blastp_CBE
58.60
39%
-12
- C5 -
-
5UR1
1
FGFR1_HUMAN
A:
[19-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PP-----------------
Y
--
N
P
S
H
----
N
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
----------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
145
Blastp_CBE
58.59
39%
7
- C5 -
-
5FXR
1
A:
[7-305]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
-
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------
M
E
-----
N
--
N
P
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
---
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
-------------------------------------------------------------------------------------------
154
Blastp_CBE
58.55
40%
-38
- C5 -
-
3EKK
1
A:
[15-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
----------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
551
Blastp_CBE
58.49
38%
8
- C5 -
-
5A46
4
FGFR1_HUMAN
A:
[37-329]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PPGL------------------------------
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
----
L
T
S
N
Q
E
-----------------------------------------------------------------------------------------
481
Blastp_CBE
58.35
39%
-26
- C5 -
-
6C1C
1
B:
[19-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
---
E
A
IGL--
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P-----------------------------------QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
--------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
488
Blastp_CBE
58.33
39%
-8
- C5 -
-
6C18
1
FGFR1_HUMAN
A:
[19-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
----
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PPG----------
S
-----
Y
--
N
P
S
H
----
N
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
----------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
136
Blastp_CBE
58.19
39%
15
- C5 -
-
1JQH
1
C:
[7-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------------------
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
-------
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
156
Blastp_CBE
58.16
39%
14
- C5 -
-
3LVP
1
IGF1R_HUMAN
C:
[37-335]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------------------
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
241
Blastp_CBE
58.07
40%
-9
- C5 -
-
6NEC
1
C:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-----------
V
------------
E
RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
-------------
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
137
Blastp_CBE
58.00
39%
10
- C5 -
-
1JQH
1
IGF1R_HUMAN
B:
[7-307]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
P------------------------------
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
-------
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
531
Blastp_CBE
57.99
38%
-7
- C5 -
-
3GQL
1
FGFR1_HUMAN
B:
[25-317]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PP-----------------------------
P
--
E
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
----
L
T
S
N
Q
E
-----------------------------------------------------------------------------------------
243
Blastp_CBE
57.90
40%
-9
- C5 -
-
2IVS
3
B:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-------------------------RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
---------------
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
522
Blastp_CBE
57.80
39%
-6
- C5 -
-
6NVL
1
FGFR1_HUMAN
A:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PP----------------------------------QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
--------
Y
--
Y
--
K
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
95
Blastp_CBE
57.82
41%
-85
- C5 -
-
4IWD
1
A:
[9-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
D
L
S
A
L
N
P
E
L
V
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--
N
D
----
G
---
K
K
I
H
C
A
V
K
S
L
N
R
-
I
T
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
E
G
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
S
--
V
--
H
N
K
T
----
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
89
Blastp_CBE
57.82
42%
-34
- C5 -
-
4KNB
1
D:
[5-285]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
A
V
Q
H
V
V
I
G
P
S
------
S
L
I
VH
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
L
----
L
D
--------
G
---
K
K
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
S
--
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
-
H
P
N
V
L
S
L
L
G
I
C
L
R
S
--
S
-----
P
L
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
-----------------
I
R
-----
N
--
E
T
H
N
----
P
T
--
V
K
-----
D
L
I
G
F
G
---
L
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
---
D
---
E
K
F
T
----
V
K
V
A
D
F
G
L
A
R
D
M
-------------------
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
--------
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
---
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
----
S
E
L
V
S
R
I
S
A
I
F
S
T
F
-------------------------------------------------------------------------------------------------
473
Blastp_CBE
57.80
39%
2
- C5 -
-
1FGI
1
B:
[18-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGL------
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
------------------------------------QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
------
D
Y
--
Y
--
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------
144
Blastp_CBE
57.69
39%
18
- C5 -
-
2OJ9
1
A:
[6-306]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
V
Y
V
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE-----------------------------
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
158
Blastp_CBE
57.55
39%
7
- C5 -
-
3LVP
2
IGF1R_HUMAN
A:
[39-335]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
D
E
WEVARE
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------
M
E
---------
P
V
L
----
A
P
PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
Y
-----------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
274
Blastp_CBE
57.12
39%
-16
- C5 -
-
2X2L
5
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-----------
V
-------------RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
464
Blastp_CBE
56.98
39%
-7
- C5 -
-
3RHX
2
B:
[14-302]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGL------
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
------------------------------------QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
------
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------
451
Blastp_CBE
56.64
39%
0
- C5 -
-
4F63
3
B:
[17-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
---
E
A
IGL------
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
------------------------------------QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
------
D
Y
--
Y
--
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------
441
Blastp_CBE
56.63
39%
3
- C5 -
-
4NKS
1
B:
[17-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
---
E
A
IGL------
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
------------------------------------QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
------
D
Y
--
Y
--
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------
530
Blastp_CBE
56.52
38%
-6
- C5 -
-
3GQL
1
C:
[25-318]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PP---------------------------------
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
R
--------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
----
L
T
S
N
Q
E
Y
----------------------------------------------------------------------------------------
435
Blastp_CBE
56.28
39%
2
- C5 -
-
4V01
6
B:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
--
G
Q
V
V
L
A
---
E
A
IGLD-----
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
P-----------------------------------QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
--------
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
436
Blastp_CBE
56.21
39%
-3
- C5 -
-
4V01
6
FGFR1_HUMAN
A:
[17-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
----
G
Q
V
V
L
A
---
E
A
IGL--
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
PP----------------------------------QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
--------
I
D
Y
--
Y
--
K
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
258
Blastp_CBE
56.15
41%
-18
- C5 -
-
6FEK
3
A:
[20-295]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-----------
V
G
-----
P
--
G
P
D
E
RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
F
--
V
--
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
275
Blastp_CBE
56.12
39%
-16
- C5 -
-
2X2K
4
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-----------
V
-------------RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
485
Blastp_CBE
56.04
39%
-13
- C5 -
-
6C19
1
B:
[19-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
---
G
Q
V
V
L
A
---
E
A
IGLD
K
D
--
K
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
-----------------------------------
E
QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
---------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
S
------------------------------------------------------------------------------------------------
277
Blastp_CBE
55.91
39%
-18
- C5 -
-
2IVT
3
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-----------
V
-------------RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
449
Blastp_CBE
55.90
39%
-1
- C5 -
-
4F64
3
B:
[17-305]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
R
D
------
R
L
V
--
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
A
IGL------
P
----
N
---
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
S
--
D
L
I
S
E
M
E
M
M
K
M
I
G
K
-
H
K
N
I
I
N
L
L
G
A
C
T
Q
D
---
G
P
L
---
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
Q
A
R
R
------------------------------------QLSSK
D
L
V
S
C
A
---
Y
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
---
T
---
E
D
N
V
----
M
K
I
A
D
F
G
L
A
------
D
Y
--
Y
--
K
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
----
K
Q
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------------------
276
Blastp_CBE
55.52
39%
-4
- C5 -
-
2IVU
3
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
--------------------------RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
270
Blastp_CBE
55.41
39%
-23
- C5 -
-
2IVV
3
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
------------------------------
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
S
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
271
Blastp_CBE
55.33
39%
-21
- C5 -
-
4CKJ
16
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-----------
V
-------------RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
293
Blastp_CBE
55.30
42%
-45
- C5 -
-
3ZBF
1
A:
[30-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
E
------
K
L
T
--
L
--
R
L
L
L
G
S
---
G
E
V
Y
E
G
---
T
A
----
V
D
--
I
L
----
G
VGS
G
E
I
K
V
A
V
K
T
L
K
K
---
G
S
T
D
Q
E
KI
E
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
P
Q
------
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
------------
M
A
---------
T
F
Y
----
G
P
--
L
L
-----
T
L
V
D
L
V
DLC
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
V--
K
D
Y
T
SPRI
V
K
I
G
D
F
G
L
A
R
D
I
Y
----------------
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
-
G
H
Q
P
Y
P
A
H
S
N
L
D
V
L
N
Y
V
Q
T
-------
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
----
H
R
I
Q
D
Q
L
Q
-------------------------------------------------------------------------------------------------------
416
Blastp_CBE
54.88
39%
-9
- C5 -
-
6NE7
2
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
A
S
L
R
G
F
L
R
E
S
R
K-----------
V
G
-----------
E
RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
V
--
K
--
R
--
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
300
Blastp_CBE
54.77
39%
-22
- C5 -
-
4XLV
1
?
A:
[36-308]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
-------
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
273
Blastp_CBE
54.77
39%
-14
- C5 -
-
2X2M
3
RET_HUMAN
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
--
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
---------------------------RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
331
Blastp_CBE
54.69
39%
-7
- C5 -
-
6NJA
2
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-----------
V
------------
E
RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
V
--
K
--
R
--
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
292
Blastp_CBE
54.63
42%
-32
- C5 -
-
4UXL
1
A:
[30-306]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
E
------
K
L
T
--
L
--
R
L
L
L
G
S
G
A
F
G
E
V
Y
E
G
---
T
A
----
V
D
--
I
L
----
G
VGS
G
E
I
K
V
A
V
K
T
L
K
K
---
G
S
T
D
Q
E
KI
E
F
L
K
E
A
H
L
M
S
K
F
-
N
-
H
P
N
I
L
K
Q
L
G
V
C
L
L
N
E
P
Q
------
Y
I
I
L
E
L
M
E
G
G
D
L
L
T
Y
L
R
K
A
R
------------
M
A
---------
T
F
Y
----
G
P
--
L
L
-----
T
L
V
D
L
V
DLC
V
D
I
S
K
G
C
V
Y
L
E
R
M
H
F
I
H
R
D
L
A
A
R
N
C
L
V
---
S
V--
K
D
Y
T
SPRI
V
K
I
G
D
F
G
L
A
R
D
I
Y
K
------------
E
G
L
L
P
V
R
W
M
A
P
E
S
L
M
D
G
I
F
T
T
Q
S
D
V
W
S
F
G
I
L
I
W
E
I
L
T
L
-
G
H
Q
P
Y
P
A
H
S
N
L
D
V
L
N
Y
V
Q
T
-------
G
G
R
L
E
P
P
R
N
C
P
D
D
L
W
N
L
M
T
Q
C
W
A
Q
E
P
D
Q
R
P
T
F
----
H
R
I
Q
D
Q
L
Q
-------------------------------------------------------------------------------------------------------
268
Blastp_CBE
54.48
41%
-6
- C5 -
-
5AMN
7
A:
[20-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-----------
V
----------
E
R
A
----
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
V
--
K
--
R
--
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
384
Blastp_CBE
54.47
39%
-12
- C5 -
-
4CKI
8
A:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
R
K-----------
V
-----------
D
E
RA--
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
V
--
K
--
R
--
S
Q
G
R
I
P
V
K
W
T
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
415
Blastp_CBE
54.17
37%
-17
- C5 -
-
1K3A
1
A:
[7-298]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
R
E
------
K
I
T
--
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
A
----
K
G
VV
K
D
----
E
---
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
E
F
-
N
-
C
H
H
V
V
R
L
L
G
V
V
S
Q
G
Q
P
------
T
L
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
R
S
L
R
PE----------
M
-------------------PS
L
S
-----
K
M
I
Q
M
A
---
G
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
E
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
-------
R
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
LEII
S
S
I
K
E
E
M
E
P
G
F
R
E
V
S
F
Y
Y
S
E
E
N
-----------------------------------------------------------------------------------------
288
Blastp_CBE
53.76
40%
-13
- C5 -
-
1IR3
1
A:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
-------
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
289
Blastp_CBE
53.46
40%
-13
- C5 -
-
1GAG
1
A:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
-------
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
307
Blastp_CBE
53.34
39%
-16
- C5 -
-
1RQQ
1
B:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
-------
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
272
Blastp_CBE
53.08
39%
-8
- C5 -
-
2X2M
4
B:
[20-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
P
R
K
------
N
L
V
--
L
--
G
K
T
L
G
E
----
K
V
V
K
A
TAF
H
L
----
K
G
--
R
A
----
G
----
Y
T
T
V
A
V
K
M
L
K
E
N
A
-
S
P
S
E
L
R
--
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
-
H
P
H
V
I
K
L
Y
G
A
C
S
Q
D
---
G
P
L
---
L
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
R
E
S
---------------------------A---
L
T
--
M
G
-----
D
L
I
S
F
A
---
W
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
---
A
---
E
G
R
K
----
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
R
-
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
----
A
D
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------------------
308
Blastp_CBE
53.00
39%
-13
- C5 -
-
1RQQ
1
INSR_HUMAN
A:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
-------
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
287
Blastp_CBE
51.93
40%
-15
- C5 -
-
2Z8C
1
A:
[11-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
-------
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------
302
Blastp_CBE
50.50
39%
-17
- C5 -
-
3BU5
1
A:
[14-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
R
E
------
K
I
T
--
L
--
L
R
E
L
G
Q
---
G
M
V
Y
E
G
---
N
A
----
R
D
II
K
G
----
E
---
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
E
---
F
L
N
E
A
S
V
M
K
G
F
-
T
-
C
H
H
V
V
R
L
L
G
V
V
S
K
G
Q
P
T
------
L
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
R
S
L
R
PE----------
A
E
-----
N
--
N
P
G
R
----
P
P
PT
L
Q
-----
E
M
I
Q
M
A
---
A
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
---
A
---
H
D
F
T
----
V
K
I
G
D
F
G
M
T
R
D
I
E
T
D
-------
R
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
--------
L
E
I
V
N
L
L
----------------------------------------------------------------------------------------------------