@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : UFO_HUMAN: (2020-09-24 )
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSNDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
Atome Classification :
(422 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520........530-.......--.540.......550.---.---.-.---..---.----560.......570.......-580.......590-.......600...--....610.....-..620.......630--....-----.-.-----.--640.---------..--.-..---------.-----650..-.....660.......670.......680--........690.......700--.--.--.....710.......720.......730.......740...-....750.......760..-------.....770.......780.......790......----.800.......810.....-..820.......830.......840.......850.......860.......870.......880.......890..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MAWRCPRMGR
V
P
L
A
W
C
L
A
L
CGWACMAPRGTQAEESPFVGNPGNITGARGL
T
G
T
L
R
C
Q
L
Q
VQGEPP
E
V
H
WLRDG
Q
I
L
E
LADSTQTQVPLGEDEQD
D
W
I
V
V
S
Q
L
R
I
T
S
L
Q
LSDTG
Q
Y
Q
C
L
V
F
LG
H
Q
T
F
VSQPGYVGLEGL
P
Y
F
LEEPED
R
T
VAANTP
F
N
L
S
CQAQGPPEP
V
D
L
L
W
LQDAVPLATAPGHGPQRSLHVPGLNKTS
S
F
S
C
EAHNAKG
V
T
TS
R
T
A
T
I
T
VLPQQPR
N
L
H
L
VSRQP
T
E
L
E
V
A
WTPGLSGI
Y
P
L
T
H
C
T
L
Q
A
V
L
SNDGMGIQAGEPDPPEEPLTSQASV
P
P
H
Q
L
R
LGSLHPHT
P
Y
H
I
R
V
A
C
TSSQGPSSW
T
H
W
L
PVETPEGVPLGPPENISATRNG
S
Q
A
F
V
H
WQEPRAPLQG
T
L
L
G
Y
R
L
A
YQGQD
T
P
E
V
L
M
D
IGLR
Q
E
V
T
L
E
L
QGDGSV
S
N
L
T
V
C
V
A
A
Y
TAAGDGPWSLPV
P
L
EAWRPGQ
A
Q
P
V
H
Q
L
V
KEPSTPAFS
W
P
W
W
Y
V
L
L
G
A
V
V
A
A
A
C
V
L
I
L
A
L
F
L
V
H
RRKKETRYGEVFEPTVERG
E
L
V
V
R
Y
R
V
R
K
S
YSRRT
T
E
A
T
L
N
SLGI
S
E
-
E
L
K
E
K
L
R
D
V
M
V
--
D
R
H
K
V
A
L--GKTLGEGEF
G
A
VMEG---Q---L-N---QD---
D
----
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
-
E
D
F
L
S
E
A
V
C
M
K
EF-DH
P
N
V
M
R
L
I
G
V
CF--QGSERESFPA
P
V
-
V
I
L
P
FMKHG
D
L
H
S
F
L
--
L
Y
S
R-----L-G-----D--QPVY---------
L
P
--
T
-
Q
M
---------
L
-----
V
K
F
M
A
-
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
RNCMLN---ENM
S
V
C
VADFGLS
K
K
IYNG
D
Y
--Y--R--QGRIAKM
P
V
K
W
I
A
I
E
S
L
A
D
R
VYTSKSDV
W
S
FG
V
T
M
W
E
I
ATR-GQTPYPGVE
N
S
E
I
Y
D
Y
L
R
Q-------GNRLK
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
CWELNPQDRP
S
F
T
E
----
L
R
E
D
L
E
N
T
L
K
ALPPAQEPD-
E
I
L
Y
V
NMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCL
T
A
AEVHPA
G
R
Y
V
L
CPSTTPSPAQPADRGSPAAPGQEDGA
23
Blastp_CBE
91.06
100%
-142
- C5 -
-
5U6B
1
UFO_HUMAN
B:
[3-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
G
I
S
E
-
E
L
K
E
K
L
R
D
V
M
V
--
D
R
H
K
V
A
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
---
L
-
N
---
Q
---------
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
-
E
D
F
L
S
E
A
V
C
M
K
E
F
-
D
H
P
N
V
M
R
L
I
G
V
C
F
------
R
E
S
F
P
A
P
V
-
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
L
Y
S
R
-----
L
-
G
-----
D
--
Q
P
V
Y
---------
L
P
--
T
-
Q
M
---------
L
-----
V
K
F
M
A
-
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
M
S
V
C
V
A
D
F
G
L
S
K
K
I
Y
N
G
D
Y
--
Y
-------
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
----
L
R
E
D
L
E
N
T
L
K
A
L
P
------------------------------------------------------------------------------------
21
Blastp_CBE
90.98
100%
-142
- C5 -
-
5U6B
1
D:
[3-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
S
L
G
I
S
E
-
E
L
K
E
K
L
R
D
V
M
V
--
D
R
H
K
V
A
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
---
L
-
N
---
Q
---------
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
-
E
D
F
L
S
E
A
V
C
M
K
E
F
-
D
H
P
N
V
M
R
L
I
G
V
C
F
------
R
E
S
F
P
A
P
V
-
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
L
Y
S
R
-----
L
-
G
-----
D
--
Q
P
V
Y
---------
L
P
--
T
-
Q
M
---------
L
-----
V
K
F
M
A
-
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
M
S
V
C
V
A
D
F
G
L
S
K
K
I
Y
N
G
D
Y
--
Y
-------
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
----
L
R
E
D
L
E
N
T
L
K
A
L
P
------------------------------------------------------------------------------------
548
HHSearch
89.38
100%
-144
- C5 -
-
5U6B
1
UFO_HUMAN
B:
[12-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
L
R
D
V
M
V
--
D
R
H
K
V
A
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
---
L
-
N
---
Q
---------
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
-
E
D
F
L
S
E
A
V
C
M
K
E
F
-
D
H
P
N
V
M
R
L
I
G
V
C
F
------
R
E
S
F
P
A
P
V
-
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
L
Y
S
R
-----
L
-
G
-----
D
--
Q
P
V
Y
---------
L
P
--
T
-
Q
M
---------
L
-----
V
K
F
M
A
-
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
M
S
V
C
V
A
D
F
G
L
S
K
K
I
Y
N
G
D
Y
--
Y
-------
R
I
A
K
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
----
L
R
E
D
L
E
N
T
L
K
A
L
P
------------------------------------------------------------------------------------
1
PsiBlast_PDB
87.76
100%
-144
- C5 -
-
5U6B
1
UFO_HUMAN
A:
[10-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
K
L
R
D
V
M
V
--
D
R
H
K
V
A
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
---
L
-
N
---
Q
D
---
D
----
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
-
E
D
F
L
S
E
A
V
C
M
K
E
F
-
D
H
P
N
V
M
R
L
I
G
V
C
F
--
Q
-------
P
A
P
V
-
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
L
Y
S
R
-----
L
-
G
-----
D
--
Q
P
V
Y
---------
L
P
--
T
-
Q
M
---------
L
-----
V
K
F
M
A
-
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
M
S
V
C
V
A
D
F
G
L
S
K
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
----
L
R
E
D
L
E
N
T
L
K
A
L
P
P
A
----------------------------------------------------------------------------------
22
Blastp_CBE
87.64
100%
-144
- C5 -
-
5U6B
1
UFO_HUMAN
C:
[10-302]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
K
E
K
L
R
D
V
M
V
--
D
R
H
K
V
A
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
---
L
-
N
---
Q
D
---
D
----
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
-
E
D
F
L
S
E
A
V
C
M
K
E
F
-
D
H
P
N
V
M
R
L
I
G
V
C
F
--
Q
-------
P
A
P
V
-
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
L
Y
S
R
-----
L
-
G
-----
D
--
Q
P
V
Y
---------
L
P
--
T
-
Q
M
---------
L
-----
V
K
F
M
A
-
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
M
S
V
C
V
A
D
F
G
L
S
K
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
----
L
R
E
D
L
E
N
T
L
K
A
L
P
P
A
----------------------------------------------------------------------------------
549
HHSearch
87.14
100%
-144
- C5 -
-
5U6B
1
UFO_HUMAN
A:
[12-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
K
L
R
D
V
M
V
--
D
R
H
K
V
A
L
--
G
K
T
L
G
E
G
E
F
G
A
V
M
E
G
---
Q
---
L
-
N
---
Q
D
---
D
----
S
I
L
K
V
A
V
K
T
M
K
I
A
I
C
T
R
S
E
L
-
E
D
F
L
S
E
A
V
C
M
K
E
F
-
D
H
P
N
V
M
R
L
I
G
V
C
F
--
Q
-------
P
A
P
V
-
V
I
L
P
F
M
K
H
G
D
L
H
S
F
L
--
L
Y
S
R
-----
L
-
G
-----
D
--
Q
P
V
Y
---------
L
P
--
T
-
Q
M
---------
L
-----
V
K
F
M
A
-
D
I
A
S
G
M
E
Y
L
S
T
K
R
F
I
H
R
D
L
A
A
R
N
C
M
L
N
---
E
N
M
S
V
C
V
A
D
F
G
L
S
K
----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
S
F
G
V
T
M
W
E
I
A
T
R
-
G
Q
T
P
Y
P
G
V
E
N
S
E
I
Y
D
Y
L
R
Q
-------
G
N
R
L
K
Q
P
A
D
C
L
D
G
L
Y
A
L
M
S
R
C
W
E
L
N
P
Q
D
R
P
S
F
T
E
----
L
R
E
D
L
E
N
T
L
K
A
L
P
P
A
----------------------------------------------------------------------------------
552
HHSearch
74.62
62%
-177
- C5 -
-
3QUP
1
A:
[16-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
--
P
---
F
T
L
--
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
---
Q
---
L
-----------------
V
K
V
A
V
K
M
L
------
S
S
D
I
-
E
E
F
L
R
E
A
A
C
M
K
E
F
-
D
H
P
H
V
A
K
L
V
G
V
S
L
--
R
S
-------
I
P
M
-
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
--
L
A
S
R
-----
I
-----------
P
F
N
---------
L
P
--
L
-
Q
T
---------
L
-----
V
R
F
M
V
-
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
---
E
D
M
T
V
C
V
A
D
F
G
L
-----------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
-
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
----
L
R
M
E
L
E
N
I
L
G
H
--------------------------------------------------------------------------------------
30
Blastp_CBE
74.58
69%
-173
- C5 -
-
4M3Q
1
B:
[26-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
-----
G
S
V
M
E
G
---
N
---
L
-
K
--------------
S
L
K
V
A
V
K
T
M
-------------
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
-----------
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
15
PsiBlast_PDB
74.45
61%
-177
- C5 -
-
3QUP
1
A:
[16-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
L
I
--
P
---
F
T
L
--
G
R
M
L
G
K
G
E
F
G
S
V
R
E
A
---
Q
---
L
-----------------
V
K
V
A
V
K
M
L
------
S
S
D
I
-
E
E
F
L
R
E
A
A
C
M
K
E
F
-
D
H
P
H
V
A
K
L
V
G
V
S
L
--
R
S
-------
I
P
M
-
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
--
L
A
S
R
-----
I
-----------
P
F
N
---------
L
P
--
L
-
Q
T
---------
L
-----
V
R
F
M
V
-
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
---
E
D
M
T
V
C
V
A
D
F
G
L
-----------------------
L
P
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
-
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
----
L
R
M
E
L
E
N
I
L
G
H
--------------------------------------------------------------------------------------
3
PsiBlast_PDB
71.39
69%
-59
- C5 -
-
5U6C
1
MERTK_HUMAN
A:
[23-313]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
Q
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
M
R
L
L
G
V
C
I
--
E
M
-----
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
32
Blastp_CBE
70.96
69%
-64
- C5 -
-
3BRB
2
B:
[24-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
559
HHSearch
70.84
69%
-64
- C5 -
-
3BRB
2
B:
[24-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
Q
-
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
11
PsiBlast_PDB
70.08
69%
-68
- C5 -
-
5K0K
1
MERTK_HUMAN
A:
[26-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
-------
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
6
PsiBlast_PDB
69.99
69%
-67
- C5 -
-
3BPR
1
MERTK_HUMAN
A:
[24-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
------
R
E
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
------
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
34
Blastp_CBE
69.82
69%
-68
- C5 -
-
3BPR
1
MERTK_HUMAN
C:
[24-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
--------
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
------
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
33
Blastp_CBE
69.60
69%
-66
- C5 -
-
3BPR
1
D:
[24-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
--------
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
------
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
558
HHSearch
69.15
69%
-60
- C5 -
-
5K0X
1
MERTK_HUMAN
A:
[25-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
--
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
-------
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
12
PsiBlast_PDB
69.15
69%
-60
- C5 -
-
5K0X
1
MERTK_HUMAN
A:
[25-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
--
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
-------
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
5
PsiBlast_PDB
68.92
69%
-72
- C5 -
-
3BRB
2
MERTK_HUMAN
A:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
---
N
S
S
Q
R
E
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
--------
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
S
----------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
557
HHSearch
68.91
69%
-72
- C5 -
-
3BRB
2
MERTK_HUMAN
A:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
---
N
S
S
Q
R
E
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
--------
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
S
----------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
35
Blastp_CBE
68.90
69%
-72
- C5 -
-
3BPR
1
MERTK_HUMAN
B:
[25-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
-
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
L
-------
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
--------
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
24
Blastp_CBE
68.70
69%
-70
- C5 -
-
5U6C
1
B:
[26-313]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
---------
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
M
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
-------------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
4
PsiBlast_PDB
68.69
69%
-78
- C5 -
-
2P0C
2
MERTK_HUMAN
A:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
--
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
------------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
----------
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
7
PsiBlast_PDB
68.41
69%
-68
- C5 -
-
3TCP
1
MERTK_HUMAN
A:
[26-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
-----
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
-------
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
13
PsiBlast_PDB
67.64
69%
-68
- C5 -
-
6MEP
1
MERTK_HUMAN
A:
[25-311]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
-------------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
------------
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
S
-----------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
561
HHSearch
67.63
38%
-123
- C5 -
-
3BKB
7
A:
[110-375]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
L
--
N
H
E
D
L
V
L
--
G
E
Q
I
G
R
G
N
F
G
E
V
F
S
G
---
R
---
L
-
R
---
A
D
---
N
------
T
L
V
A
V
K
S
C
R
E
T
L
-
P
P
D
L
K
-
A
K
F
L
Q
E
A
R
I
L
K
Q
Y
-
S
H
P
N
I
V
R
L
I
G
V
C
T
--
Q
K
Q
------
P
I
Y
-
I
V
M
E
L
V
Q
G
G
D
F
L
T
F
L
--
R
T
E
G
------------------
A
R
---------
L
R
--
V
-
K
T
---------
L
-----
L
Q
M
V
G
-
D
A
A
A
G
M
E
Y
L
E
S
K
C
C
I
H
R
D
L
A
A
R
N
C
L
V
T
---
E
K
N
V
L
K
I
S
D
F
G
M
S
R
E
E
A
D
G
V
Y
--
A
--
A
--
S
G
G
L
R
Q
V
P
V
K
W
T
A
P
E
A
L
N
Y
G
R
Y
S
S
E
S
D
V
W
S
F
G
I
L
L
W
E
T
F
S
L
-
G
A
S
P
Y
P
N
L
S
N
Q
Q
T
R
E
F
V
E
K
-------
G
G
R
L
P
C
P
E
L
C
P
D
A
V
F
R
L
M
E
Q
C
W
A
Y
E
P
G
Q
R
P
S
F
S
T
----
I
Y
Q
E
L
Q
S
I
R
K
R
--------------------------------------------------------------------------------------
10
PsiBlast_PDB
67.48
69%
-68
- C5 -
-
4MHA
1
MERTK_HUMAN
A:
[29-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
L
D
N
S
S
Q
R
E
I
-
E
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
-------
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
-------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
31
Blastp_CBE
67.47
69%
-70
- C5 -
-
3TCP
1
B:
[25-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
K
---------------
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
-------------------------
M
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
36
Blastp_CBE
67.45
69%
-68
- C5 -
-
2P0C
1
B:
[24-310]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
---
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
------------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
----------
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
G
L
------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.10
69%
-68
- C5 -
-
4MH7
1
MERTK_HUMAN
A:
[26-310]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
------------------
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
27
Blastp_CBE
66.94
69%
-64
- C5 -
-
5K0K
1
B:
[26-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
--
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
-----------------
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
26
Blastp_CBE
65.98
69%
-61
- C5 -
-
5K0X
1
B:
[24-311]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
K
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
--
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
-------------
E
F
L
S
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
---------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
8
PsiBlast_PDB
65.22
69%
-67
- C5 -
-
4M3Q
1
MERTK_HUMAN
A:
[27-310]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
--------------------
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
--------------------------
P
V
K
W
I
A
I
E
S
L
--
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
28
Blastp_CBE
65.04
69%
-71
- C5 -
-
4MHA
1
B:
[26-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
---------------------
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
R
V
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
484
Blastp_CBE
64.84
40%
-142
- C5 -
-
4CSV
1
?
A:
[8-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
P
R
S
E
I
T
L
--
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
---
K
---
W
-
R
---
N
Y
---
N
------
I
E
V
A
V
K
T
L
K
E
G
T
M
S
---
V
-
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
--
K
E
------
P
P
I
Y
-
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
--
R
D
C
------------------------------
V
N
--
A
-
Q
A
---------
L
-----
L
D
M
A
A
-
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
V
V
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
-------
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
----
T
L
H
A
L
E
T
M
F
----------------------------------------------------------------------------------------
298
Blastp_CBE
64.79
43%
-80
- C5 -
-
3HMI
1
ABL2_HUMAN
A:
[29-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
--
L
E
------
P
P
F
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
E
E
V
--------------
T
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-------
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
----
T
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.73
69%
-72
- C5 -
-
5TD2
1
MERTK_HUMAN
A:
[1-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
M
-----------------
A
A
C
M
K
D
F
-
S
H
P
N
V
M
R
L
L
G
V
C
I
--
E
M
S
S
------
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
--------------------------
P
V
K
W
I
A
I
E
S
L
----
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
551
HHSearch
64.69
38%
-113
- C5 -
-
6BRJ
1
DDR1_HUMAN
A:
[568-873]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
--
P
R
S
R
L
R
F
--
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
---
E
---
V
-----------------
L
L
V
A
V
K
I
L
R
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
--
Q
D
D
------
P
L
C
-
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
--
S
A
H
Q
-----
L
-
E
-----
D
----
P
T
---------
I
S
--
Y
-
P
M
---------
L
-----
L
H
V
A
A
-
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
M
S
R
N
L
Y
A
G
D
Y
--
Y
--
R
--
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
FFRDQGR
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
----
L
H
R
F
L
A
E
D
A
L
---------------------------------------------------------------------------------------
245
Blastp_CBE
64.62
43%
-75
- C5 -
-
3DK3
1
ABL1_MOUSE
A:
[8-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
-------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
F
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
167
Blastp_CBE
64.58
43%
-62
- C5 -
-
2QOH
1
ABL1_MOUSE
B:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
---
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
483
Blastp_CBE
64.56
40%
-135
- C5 -
-
4UEU
1
?
A:
[8-268]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
--
P
R
S
E
I
T
L
--
E
R
K
L
G
S
G
Q
F
G
E
V
Y
E
G
---
K
---
W
-
R
---
N
Y
---
N
------
I
E
V
A
V
K
T
L
K
E
G
T
M
S
---
V
-
E
E
F
L
Q
E
A
Q
I
M
K
K
L
-
K
H
P
N
L
V
Q
L
Y
G
V
C
T
--
K
E
------
P
P
I
Y
-
I
I
T
E
Y
M
S
H
G
S
L
L
D
Y
L
--
R
D
C
-----------------
E
G
H
T
---------
V
N
--
A
-
Q
A
---------
L
-----
L
D
M
A
A
-
Q
V
A
S
G
M
A
Y
L
E
S
Q
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
N
V
V
K
V
A
D
F
G
L
A
R
L
I
-----------------
A
K
F
P
I
K
W
T
A
P
E
A
I
S
Y
N
R
F
S
I
K
S
D
V
W
A
F
G
I
L
L
W
E
I
F
T
Y
-
G
Q
V
P
Y
P
G
M
S
G
S
E
V
I
E
Q
V
E
R
-------
G
Y
R
M
P
R
P
Q
G
C
P
E
E
I
Y
E
L
M
L
Q
C
W
N
K
S
P
E
E
R
P
T
F
A
E
----
T
L
H
A
L
E
T
M
F
----------------------------------------------------------------------------------------
166
Blastp_CBE
64.48
43%
-65
- C5 -
-
3KF4
1
ABL1_MOUSE
A:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
--------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
288
Blastp_CBE
64.37
43%
-63
- C5 -
-
1OPK
3
ABL1_MOUSE
A:
[217-490]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
157
Blastp_CBE
64.10
43%
-66
- C5 -
-
2Z60
1
ABL1_MOUSE
A:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
------
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
200
Blastp_CBE
64.07
43%
-66
- C5 -
-
4WA9
1
ABL1_HUMAN
B:
[11-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
----------------------------------------------------------------------------
155
Blastp_CBE
64.07
43%
-66
- C5 -
-
3IK3
1
ABL1_MOUSE
B:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
233
Blastp_CBE
64.05
43%
-61
- C5 -
-
2F4J
1
ABL1_HUMAN
A:
[11-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
226
Blastp_CBE
63.93
43%
-72
- C5 -
-
6NPV
2
ABL1_HUMAN
A:
[23-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
--------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
-------------------------------------------------------------------------------------
422
Blastp_CBE
63.90
43%
-63
- C5 -
-
1OPL
2
ABL1_HUMAN
A:
[256-529]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
320
Blastp_CBE
63.89
43%
-65
- C5 -
-
2FO0
3
ABL1_HUMAN
A:
[214-487]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
210
Blastp_CBE
63.86
44%
-70
- C5 -
-
2HZI
1
ABL1_HUMAN
A:
[14-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
428
Blastp_CBE
63.83
39%
-76
- C5 -
-
4CD0
1
A:
[42-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
258
Blastp_CBE
63.79
40%
-82
- C5 -
-
5AA9
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
218
Blastp_CBE
63.77
43%
-69
- C5 -
-
2G1T
1
ABL1_HUMAN
C:
[12-282]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
------------------------------------------------------------------------------
237
Blastp_CBE
63.76
43%
-66
- C5 -
-
2G2H
1
ABL1_HUMAN
A:
[12-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
---------------------------------------------------------------------------------
405
Blastp_CBE
63.66
39%
-79
- C5 -
-
4CLJ
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
257
Blastp_CBE
63.64
40%
-79
- C5 -
-
5AAA
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
179
Blastp_CBE
63.56
43%
-64
- C5 -
-
3K5V
2
ABL1_MOUSE
B:
[15-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
---
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
168
Blastp_CBE
63.56
43%
-65
- C5 -
-
2QOH
1
ABL1_MOUSE
A:
[10-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
------
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------
184
Blastp_CBE
63.50
43%
-70
- C5 -
-
1M52
3
ABL1_MOUSE
B:
[15-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
----------------------------------------------------------------------------------
219
Blastp_CBE
63.49
43%
-69
- C5 -
-
2G1T
1
ABL1_HUMAN
B:
[12-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
232
Blastp_CBE
63.46
43%
-72
- C5 -
-
3PYY
1
ABL1_HUMAN
A:
[23-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
-------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
-------------------------------------------------------------------------------------
315
Blastp_CBE
63.39
40%
-80
- C5 -
-
4CMO
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
230
Blastp_CBE
63.39
43%
-73
- C5 -
-
6NPE
2
ABL1_HUMAN
A:
[23-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
--------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
-------------------------------------------------------------------------------------
25
Blastp_CBE
63.38
69%
-62
- C5 -
-
6MEP
1
B:
[27-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
------------------
E
A
A
C
M
K
D
F
-
S
H
P
N
V
I
R
L
L
G
V
C
-------------
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
--------------------------
P
V
K
W
I
A
I
E
S
L
A
D
--
Y
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
P
------------------------------------------------------------------------------------
154
Blastp_CBE
63.34
43%
-64
- C5 -
-
3OY3
1
ABL1_MOUSE
A:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
426
Blastp_CBE
63.25
40%
-74
- C5 -
-
4MKC
3
A:
[68-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
-
S
-------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
--
Y
--
R
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
313
Blastp_CBE
63.24
40%
-83
- C5 -
-
4CMU
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
418
Blastp_CBE
63.16
40%
-80
- C5 -
-
4FOC
1
A:
[54-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
-
S
-------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
165
Blastp_CBE
63.18
43%
-65
- C5 -
-
3KF4
1
ABL1_MOUSE
B:
[10-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------
244
Blastp_CBE
63.17
43%
-69
- C5 -
-
3DK3
1
ABL1_MOUSE
B:
[8-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
----
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
F
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
--------------------------------------------------------------------------------
307
Blastp_CBE
63.16
40%
-78
- C5 -
-
5KZ0
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
421
Blastp_CBE
63.08
43%
-65
- C5 -
-
1OPL
1
ABL1_HUMAN
B:
[256-518]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------
164
Blastp_CBE
63.10
43%
-63
- C5 -
-
3KFA
1
ABL1_MOUSE
A:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
2
PsiBlast_PDB
63.10
69%
-63
- C5 -
-
5TC0
1
MERTK_HUMAN
A:
[28-311]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
V
V
I
--
D
R
N
L
L
I
L
--
G
K
I
L
G
E
G
E
F
G
S
V
M
E
G
---
N
---
L
-
K
---
Q
E
---
D
G---
T
S
L
K
V
A
V
K
T
---------------------
M
K
D
F
-
S
H
P
N
V
M
R
L
L
G
V
C
I
--
E
M
S
S
-
Q
G
I
P
K
P
M
-
V
I
L
P
F
M
K
Y
G
D
L
H
T
Y
L
--
L
Y
S
R
-----
L
-
E
-----
T
--
G
P
K
H
---------
I
P
--
L
-
Q
T
---------
L
-----
L
K
F
M
V
-
D
I
A
L
G
M
E
Y
L
S
N
R
N
F
L
H
R
D
L
A
A
R
N
C
M
L
R
---
D
D
M
T
V
C
V
A
D
F
-------------------------
M
P
V
K
W
I
A
I
E
-------
T
S
K
S
D
V
W
A
F
G
V
T
M
W
E
I
A
T
R
-
G
M
T
P
Y
P
G
V
Q
N
H
E
M
Y
D
Y
L
L
H
-------
G
H
R
L
K
Q
P
E
D
C
L
D
E
L
Y
E
I
M
Y
S
C
W
R
T
D
P
L
D
R
P
T
F
S
V
----
L
R
L
Q
L
E
K
L
L
E
S
L
-------------------------------------------------------------------------------------
236
Blastp_CBE
63.08
43%
-63
- C5 -
-
2G2H
1
ABL1_HUMAN
B:
[12-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
---------------------------------------------------------------------------------
185
Blastp_CBE
63.06
43%
-69
- C5 -
-
1M52
1
ABL1_MOUSE
A:
[15-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
160
Blastp_CBE
63.06
44%
-66
- C5 -
-
3QRJ
1
ABL1_HUMAN
B:
[15-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
158
Blastp_CBE
63.04
44%
-71
- C5 -
-
4TWP
1
ABL1_HUMAN
B:
[5-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
217
Blastp_CBE
62.99
43%
-71
- C5 -
-
2G1T
1
ABL1_HUMAN
D:
[12-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
153
Blastp_CBE
62.99
43%
-63
- C5 -
-
3OY3
1
ABL1_MOUSE
B:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
228
Blastp_CBE
62.97
43%
-71
- C5 -
-
6NPU
2
ABL1_HUMAN
A:
[23-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
--------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
-------------------------------------------------------------------------------------
171
Blastp_CBE
62.97
43%
-63
- C5 -
-
6HD4
2
ABL1_MOUSE
B:
[15-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
---
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
292
Blastp_CBE
62.90
40%
-82
- C5 -
-
5FTQ
2
A:
[19-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
--------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
-
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
341
Blastp_CBE
62.85
40%
-79
- C5 -
-
4FOD
2
A:
[34-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
-
S
-------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
209
Blastp_CBE
62.82
44%
-74
- C5 -
-
2HZI
1
ABL1_HUMAN
B:
[14-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
----
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
311
Blastp_CBE
62.80
40%
-75
- C5 -
-
4CNH
2
B:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-----------
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
Y
-----------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
193
Blastp_CBE
62.78
44%
-67
- C5 -
-
2HYY
1
ABL1_HUMAN
D:
[10-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
--
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
156
Blastp_CBE
62.78
43%
-71
- C5 -
-
3IK3
1
ABL1_MOUSE
A:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
170
Blastp_CBE
62.77
43%
-68
- C5 -
-
6HD6
2
ABL1_MOUSE
A:
[15-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
--
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
420
Blastp_CBE
62.70
40%
-76
- C5 -
-
4Z55
3
A:
[40-322]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
---------------------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
--
Y
-----
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
163
Blastp_CBE
62.65
43%
-62
- C5 -
-
3KFA
1
ABL1_MOUSE
B:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
310
Blastp_CBE
62.64
40%
-81
* C5 *
-
4CTB
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
---
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
169
Blastp_CBE
62.60
43%
-59
- C5 -
-
6HD6
1
ABL1_MOUSE
B:
[15-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
---
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
208
Blastp_CBE
62.59
44%
-67
- C5 -
-
3CS9
1
ABL1_HUMAN
A:
[14-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
-------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
299
Blastp_CBE
62.58
43%
-80
- C5 -
-
3GVU
2
ABL2_HUMAN
A:
[29-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
--
L
E
------
P
P
F
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
E
E
V
--------------
T
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
----
G
D
T
--
Y
--
T
------
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-------
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
----
T
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
407
Blastp_CBE
62.54
40%
-77
- C5 -
-
3AOX
5
A:
[44-326]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
----
G
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
291
Blastp_CBE
62.57
40%
-90
- C5 -
-
6MX8
1
A:
[18-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
---------
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
-------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
182
Blastp_CBE
62.54
43%
-61
- C5 -
-
1OPJ
2
ABL1_MOUSE
B:
[15-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
300
Blastp_CBE
62.53
43%
-69
- C5 -
-
2XYN
4
ABL2_HUMAN
C:
[29-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
--
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
--
L
E
------
P
P
F
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
E
E
V
--------------
T
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-------
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
----
T
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
172
Blastp_CBE
62.55
43%
-63
- C5 -
-
6HD4
3
ABL1_MOUSE
A:
[15-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
-
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
180
Blastp_CBE
62.54
43%
-65
- C5 -
-
3K5V
2
ABL1_MOUSE
A:
[15-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
-
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
297
Blastp_CBE
62.53
40%
-80
- C5 -
-
5AA8
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
183
Blastp_CBE
62.52
43%
-63
- C5 -
-
1OPJ
2
ABL1_MOUSE
A:
[15-288]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
241
Blastp_CBE
62.49
44%
-70
- C5 -
-
6BL8
1
ABL1_HUMAN
A:
[5-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
F
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
316
Blastp_CBE
62.48
40%
-80
- C5 -
-
4CLI
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
215
Blastp_CBE
62.41
43%
-67
- C5 -
-
3UE4
1
ABL1_HUMAN
B:
[12-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
--
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
162
Blastp_CBE
62.36
43%
-72
- C5 -
-
3OXZ
1
ABL1_MOUSE
A:
[10-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
-----------------
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
317
Blastp_CBE
62.28
40%
-79
- C5 -
-
4CCU
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
161
Blastp_CBE
62.25
44%
-71
- C5 -
-
3QRJ
1
ABL1_HUMAN
A:
[15-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
--------
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
-----------------------------------------------------------------------------------------
301
Blastp_CBE
62.24
43%
-68
- C5 -
-
2XYN
4
ABL2_HUMAN
B:
[29-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
--
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
--
L
E
------
P
P
F
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
E
E
V
--------------
T
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-------
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
----
T
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
343
Blastp_CBE
62.18
40%
-75
- C5 -
-
4DCE
1
ALK_HUMAN
A:
[34-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
---
V
-
S
--------
P
----
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
--------------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
303
Blastp_CBE
62.18
40%
-90
- C5 -
-
6EDL
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
---
V
-
S
-------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
----------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
239
Blastp_CBE
62.18
43%
-64
- C5 -
-
2G2F
1
ABL1_HUMAN
A:
[12-281]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
-------------------------------------------------------------------------------
342
Blastp_CBE
62.16
40%
-84
- C5 -
-
4DCE
1
B:
[34-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
----
E
V
Y
E
G
---
Q
---
V
-
S
-------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
---------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
309
Blastp_CBE
62.10
40%
-80
- C5 -
-
4CTC
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
----
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
--------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
212
Blastp_CBE
62.10
43%
-66
- C5 -
-
4ZOG
5
ABL1_HUMAN
A:
[9-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------
151
Blastp_CBE
62.11
41%
-17
- C5 -
-
3PLS
1
A:
[3-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
S
-
A
L
L
A
E
V
K
D
V
L
I
--
P
H
E
R
V
V
T
HS
D
R
V
I
G
K
G
H
F
G
V
V
Y
H
G
---
E
Y--
I
-
D
---
Q
A
---
Q
----
N
R
I
Q
C
A
I
K
S
L
S
-
R
I
T
E
M
Q
Q
V
-
E
A
F
L
R
E
G
L
L
M
R
G
L
-
N
H
P
N
V
L
A
L
I
G
I
M
L
PP
E
G
-------
L
P
H
-
V
L
L
P
Y
M
C
H
G
D
L
L
Q
F
I
-------------------
R
--
S
P
Q
R
---------
N
P
--
T
V
K
D
---------
L
-----
I
S
F
G
L
-
Q
V
A
R
G
M
E
Y
L
A
E
Q
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
S
F
T
V
K
V
A
D
F
G
L
A
R
D
I
L
D
R
E
Y
--
Y
SV
Q
--
Q
H
R
H
A
R
L
P
V
K
W
T
A
L
E
S
L
Q
T
Y
R
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
L
T
R
-
G
A
P
P
Y
R
H
I
D
P
F
D
L
T
H
F
L
A
Q
-------
G
R
R
L
P
Q
P
E
Y
C
P
D
S
L
Y
Q
V
M
Q
Q
C
W
E
A
D
P
A
V
R
P
T
F
R
V
----
L
V
G
E
V
E
Q
I
V
S
A
L
-------------------------------------------------------------------------------------
159
Blastp_CBE
62.10
44%
-67
- C5 -
-
4TWP
1
ABL1_HUMAN
A:
[5-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
--------
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
318
Blastp_CBE
62.07
40%
-80
- C5 -
-
4CCB
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-----------
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
296
Blastp_CBE
62.02
40%
-81
- C5 -
-
5AAB
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
--
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
F
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
287
Blastp_CBE
62.01
40%
-82
- C5 -
-
4ANQ
1
A:
[42-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
286
Blastp_CBE
61.98
43%
-73
- C5 -
-
4XLI
1
ABL2_MOUSE
A:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
V
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
-------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
--
L
E
------
P
P
F
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
S
-----
R
--
E
E
V
--------------
T
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-------
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
----
T
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
222
Blastp_CBE
61.97
44%
-63
- C5 -
-
2HZ0
1
ABL1_HUMAN
A:
[10-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
214
Blastp_CBE
61.93
43%
-76
- C5 -
-
4YC8
3
ABL1_HUMAN
A:
[12-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
------
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
----
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------
430
Blastp_CBE
61.91
40%
-78
- C5 -
-
5A9U
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
197
Blastp_CBE
61.89
44%
-66
- C5 -
-
3QRK
1
ABL1_HUMAN
A:
[15-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
-----------------------------------------------------------------------------------------
213
Blastp_CBE
61.88
43%
-75
- C5 -
-
4YC8
3
ABL1_HUMAN
B:
[12-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
------
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
305
Blastp_CBE
61.84
40%
-81
- C5 -
-
6E0R
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
----
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
-----------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
419
Blastp_CBE
61.82
40%
-79
- C5 -
-
4FOB
1
A:
[54-336]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
-
S
-------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-----------
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
211
Blastp_CBE
61.79
43%
-68
- C5 -
-
4ZOG
2
ABL1_HUMAN
B:
[9-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
----
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
----------------------------------------------------------------------------------
285
Blastp_CBE
61.77
43%
-74
- C5 -
-
4XLI
1
B:
[5-265]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
----
G
E
V
Y
V
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
T
--
L
E
------
P
P
F
Y
-
I
V
T
E
Y
M
P
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
S
-----
R
--
E
E
V
--------------
T
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
V
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
T
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
D
L
L
E
K
-------
G
Y
R
M
E
Q
P
E
G
C
P
P
K
V
Y
E
L
M
R
A
C
W
K
W
S
P
A
D
R
P
S
F
A
E
----
T
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
429
Blastp_CBE
61.72
40%
-79
- C5 -
-
5AAC
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
E
V
Y
S
E
Q
D
E
L
--
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
314
Blastp_CBE
61.71
40%
-80
- C5 -
-
4CMT
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-----------
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
249
Blastp_CBE
61.72
43%
-72
- C5 -
-
4XEY
1
ABL1_HUMAN
B:
[122-389]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
------
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
---------------------------------------------------------------------------------
195
Blastp_CBE
61.71
44%
-62
- C5 -
-
2HYY
1
ABL1_HUMAN
B:
[10-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
-
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
295
Blastp_CBE
61.70
40%
-78
- C5 -
-
2XB7
1
A:
[19-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
--------------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
100
Blastp_CBE
61.67
42%
-71
- C5 -
-
3DKF
1
A:
[33-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
---------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
-----------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
--------------------------------------------------------------------
198
Blastp_CBE
61.65
44%
-71
- C5 -
-
3QRI
1
ABL1_HUMAN
B:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
--------
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
220
Blastp_CBE
61.62
43%
-67
- C5 -
-
2G1T
1
ABL1_HUMAN
A:
[12-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
196
Blastp_CBE
61.58
44%
-65
- C5 -
-
2HYY
1
ABL1_HUMAN
A:
[10-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
-
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
224
Blastp_CBE
61.55
43%
-69
- C5 -
-
2HIW
1
ABL1_HUMAN
A:
[12-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------
227
Blastp_CBE
61.52
43%
-80
- C5 -
-
6NPU
5
ABL1_HUMAN
B:
[23-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
----------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
216
Blastp_CBE
61.52
43%
-66
- C5 -
-
3UE4
1
ABL1_HUMAN
A:
[12-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
186
Blastp_CBE
61.41
43%
-64
- C5 -
-
1IEP
1
ABL1_MOUSE
B:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
327
Blastp_CBE
61.38
40%
-80
- C5 -
-
4ANS
1
A:
[42-324]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
A
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
406
Blastp_CBE
61.34
39%
-79
- C5 -
-
2YFX
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
M
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
------------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
294
Blastp_CBE
61.30
40%
-84
- C5 -
-
2XBA
1
A:
[19-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
-------
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
----------------
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
284
Blastp_CBE
61.27
43%
-77
- C5 -
-
5MO4
2
ABL1_HUMAN
A:
[217-490]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
-----
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
N
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
-------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
187
Blastp_CBE
61.27
43%
-65
- C5 -
-
1IEP
1
ABL1_MOUSE
A:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
189
Blastp_CBE
61.09
43%
-66
- C5 -
-
1FPU
1
ABL1_MOUSE
A:
[15-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------
225
Blastp_CBE
61.08
43%
-76
- C5 -
-
6NPV
5
ABL1_HUMAN
B:
[23-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
----------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
319
Blastp_CBE
61.02
40%
-81
- C5 -
-
2XP2
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
--
G
A
F
G
E
V
Y
E
G
---
Q
---
V
----------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-----------
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
199
Blastp_CBE
60.97
44%
-64
- C5 -
-
3QRI
1
ABL1_HUMAN
A:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
177
Blastp_CBE
60.94
43%
-63
- C5 -
-
3MS9
2
ABL1_MOUSE
B:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
250
Blastp_CBE
60.89
43%
-68
- C5 -
-
4XEY
1
ABL1_HUMAN
A:
[122-388]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
----
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
----------------------------------------------------------------------------------
188
Blastp_CBE
60.88
43%
-66
- C5 -
-
1FPU
1
ABL1_MOUSE
B:
[15-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
------
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------
328
Blastp_CBE
60.84
40%
-70
- C5 -
-
4TT7
5
A:
[18-300]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
----
G
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-----------
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
S
------
R
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
181
Blastp_CBE
60.82
43%
-65
- C5 -
-
2HZN
1
ABL1_MOUSE
A:
[15-279]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
---
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
--
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
------------------------------------------------------------------------------------
194
Blastp_CBE
60.76
44%
-66
- C5 -
-
2HYY
1
ABL1_HUMAN
C:
[10-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
-
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
---
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
206
Blastp_CBE
60.72
44%
-83
- C5 -
-
3CS9
1
ABL1_HUMAN
C:
[14-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
--------
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
312
Blastp_CBE
60.71
40%
-78
- C5 -
-
4CNH
1
ALK_HUMAN
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
------
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
----------------
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
229
Blastp_CBE
60.67
43%
-75
- C5 -
-
6NPE
3
ABL1_HUMAN
B:
[23-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
------------------------
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
231
Blastp_CBE
60.65
43%
-77
- C5 -
-
3PYY
3
ABL1_HUMAN
B:
[23-296]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
----------------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
E
-
K
E
L
--------------------------------------------------------------------------
204
Blastp_CBE
60.63
44%
-77
- C5 -
-
5HU9
14
ABL1_HUMAN
A:
[14-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
---------------
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
223
Blastp_CBE
60.61
43%
-61
- C5 -
-
2HIW
1
ABL1_HUMAN
B:
[12-274]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
--------------------------------------------------------------------------------------
175
Blastp_CBE
60.54
43%
-66
- C5 -
-
3MSS
2
ABL1_MOUSE
B:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
205
Blastp_CBE
60.46
44%
-66
- C5 -
-
3CS9
1
ABL1_HUMAN
D:
[14-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
------------------
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
173
Blastp_CBE
60.45
43%
-66
- C5 -
-
3MSS
2
ABL1_MOUSE
D:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
234
Blastp_CBE
60.42
43%
-62
- C5 -
-
2G2I
1
ABL1_HUMAN
B:
[12-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
----
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
-------------------------------------------------------------------------------------
308
Blastp_CBE
60.31
40%
-76
- C5 -
-
5IMX
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
-----------
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
----------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
202
Blastp_CBE
60.25
43%
-72
- C5 -
-
2E2B
1
ABL1_HUMAN
B:
[15-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
--------
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
-------
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
207
Blastp_CBE
60.14
44%
-81
- C5 -
-
3CS9
1
ABL1_HUMAN
B:
[14-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
-------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
174
Blastp_CBE
60.11
43%
-70
- C5 -
-
3MSS
2
ABL1_MOUSE
C:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
240
Blastp_CBE
60.04
44%
-70
- C5 -
-
6BL8
1
ABL1_HUMAN
B:
[5-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
---
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
F
--
T
--
A
H
-
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
178
Blastp_CBE
59.99
43%
-65
- C5 -
-
3MS9
2
ABL1_MOUSE
A:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
--
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
238
Blastp_CBE
59.92
43%
-60
- C5 -
-
2G2F
1
ABL1_HUMAN
B:
[12-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
-----
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
203
Blastp_CBE
59.82
43%
-65
- C5 -
-
2E2B
1
ABL1_HUMAN
A:
[15-280]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
----
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
----
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
323
Blastp_CBE
59.77
40%
-78
- C5 -
-
5IUG
1
A:
[28-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
----
G
E
V
Y
E
G
---
Q
---
V
---------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----------
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
176
Blastp_CBE
59.67
43%
-67
- C5 -
-
3MSS
2
ABL1_MOUSE
A:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
---------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
-
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
409
Blastp_CBE
59.44
40%
-19
- C5 -
-
3LCT
3
A:
[45-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
-
S
GMP
N
D
---
P
----
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
--
Y
--
R
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
235
Blastp_CBE
59.38
43%
-67
- C5 -
-
2G2I
1
ABL1_HUMAN
A:
[12-277]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
---
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
P
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
-----------------------------------------------------------------------------------
16
PsiBlast_PDB
59.33
61%
-68
- C5 -
-
4FEQ
1
A:
[22-300]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
Q
Q
F
T
L
--
G
R
M
L
G
K
---
G
S
V
R
E
A
---
Q
---
L
-
K
--------
D
G---
S
F
V
K
V
A
V
K
M
L
-------------
F
L
R
E
A
A
C
M
K
E
F
-
D
H
P
H
V
A
K
L
V
G
V
S
-------------
P
M
-
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
--
L
A
S
R
-----
I
------------------------
P
--
L
-
Q
T
---------
L
-----
V
R
F
M
V
-
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
---
E
D
M
T
V
C
V
A
D
F
G
--------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
-
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
E
E
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
----
L
R
M
E
L
E
N
I
L
G
H
L
-------------------------------------------------------------------------------------
553
HHSearch
59.07
38%
-57
- C5 -
-
6BSD
1
DDR1_HUMAN
A:
[567-873]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
--
P
R
S
R
L
R
F
--
K
E
K
L
G
E
G
Q
F
G
E
V
H
L
C
---
E
---
V
-
D
---
S
----------
P
L
L
V
A
V
K
I
L
R
P
D
A
-
T
K
N
A
R
-
N
D
F
L
K
E
V
K
I
M
S
R
L
-
K
D
P
N
I
I
R
L
L
G
V
C
V
--
Q
D
D
------
P
L
C
-
M
I
T
D
Y
M
E
N
G
D
L
N
Q
F
L
--
S
A
H
Q
-----
L
-
E
-----
D
KA-
G
P
T
---------
I
S
--
Y
-
P
M
---------
L
-----
L
H
V
A
A
-
Q
I
A
S
G
M
R
Y
L
A
T
L
N
F
V
H
R
D
L
A
T
R
N
C
L
V
G
---
E
N
F
T
I
K
I
A
D
F
G
--
R
N
L
Y
A
G
D
Y
--
Y
--
R
--
V
Q
G
R
A
V
L
P
I
R
W
M
A
W
E
C
I
L
M
G
K
F
T
T
A
S
D
V
W
A
F
G
V
T
L
W
E
V
L
M
L
C
R
A
Q
P
F
G
Q
L
T
D
E
Q
V
I
E
N
A
G
E
FFRDQGR
Q
V
Y
L
S
R
P
P
A
C
P
Q
G
L
Y
E
L
M
L
R
C
W
S
R
E
S
E
Q
R
P
P
F
S
Q
----
L
H
R
F
L
A
E
D
A
L
---------------------------------------------------------------------------------------
191
Blastp_CBE
59.05
44%
-65
- C5 -
-
2HZ4
1
ABL1_HUMAN
B:
[10-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
-----
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
101
Blastp_CBE
58.98
42%
-28
- C5 -
-
3DKC
1
A:
[33-317]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
DS
V
--
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
V
N
V
K
E
G
-------------------------------------------------------------------
410
Blastp_CBE
58.95
40%
-22
- C5 -
-
3LCS
3
A:
[45-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
-
S
GMP
N
D
---
P
----
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
--
Y
--
R
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
460
Blastp_CBE
58.94
39%
-49
- C5 -
-
2IJM
1
B:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
--
Q
R
E
R
I
E
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I--
Y
---
M
-
S
---
P
E
---
N
----
P
A
L
A
V
A
I
K
T
C
K
N
--
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
--
E
N
--------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
--
Q
V
R
K
-----
Y
-
S
---------------------
L
D
--
L
-
A
S
---------
L
-----
I
L
Y
A
Y
-
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
----
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
E
--------------------------------------------------------------------------------
427
Blastp_CBE
58.91
40%
-18
- C5 -
-
3L9P
4
A:
[68-350]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
-
S
G------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
G
Y
--
Y
--
R
--
K
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
56
Blastp_CBE
58.88
46%
-64
- C5 -
-
4XMO
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
----------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
321
Blastp_CBE
58.86
40%
-19
- C5 -
-
5IUI
1
A:
[28-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
-
S
G-------
P
----
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
A
-----------
G
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
58
Blastp_CBE
58.83
46%
-62
- C5 -
-
4DEH
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
----------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-------
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
542
Blastp_CBE
58.68
41%
-1
- C5 -
-
4J96
1
FGFR2_HUMAN
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
-----
M
--
E
Y
S
Y
DINRVPEEQ
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
221
Blastp_CBE
58.50
44%
-88
- C5 -
-
2HZ0
1
ABL1_HUMAN
B:
[10-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
------
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
----
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
------------------------
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
----------------------------------------------------------------------------------------
304
Blastp_CBE
58.44
40%
-76
- C5 -
-
6EBW
1
A:
[27-309]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
--
F
G
E
V
Y
E
G
---
Q
---
V
-
S
-------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
---------
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
--------------------
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
556
HHSearch
58.29
41%
-3
- C5 -
-
5A46
2
B:
[35-325]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
E
L
--
P
R
D
R
L
V
L
--
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
---
E
---
A
-
I
---
G
L
----DKPN
R
V
T
K
V
A
V
K
M
L
K
S
D
A
-
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
G
------
P
L
Y
-
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-----
P
-
P
------HN
P
E
E
Q
---------
L
S
--
S
-
K
D
---------
L
-----
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
A
L
T
-------------------------------------------------------------------------------------
532
Blastp_CBE
58.23
41%
-8
- C5 -
-
4J99
1
?
C:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
-----
M
--
E
Y
S
Y
DQ-------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
119
Blastp_CBE
58.23
42%
-10
- C5 -
-
5FXS
1
A:
[16-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
M
-
E
-----
N
--
N
P
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
A
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
E
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
IISS
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
293
Blastp_CBE
58.20
40%
-32
- C5 -
-
5FTO
1
A:
[19-301]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
G
A
F
G
E
V
Y
E
G
---
Q
---
V
-
S
GM-----------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
R
-------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
201
Blastp_CBE
58.12
43%
-58
- C5 -
-
4WA9
1
ABL1_HUMAN
A:
[11-278]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
------------------------
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
----
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
-
L
M
T
G
D
T
--
Y
--
T
--
A
H
A
G
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
---------------------------------------------------------------------------------
461
Blastp_CBE
58.07
39%
-48
- C5 -
-
2IJM
1
FAK1_HUMAN
A:
[6-280]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
E
I
--
Q
R
E
R
I
E
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I--
Y
---
M
-
S
---
P
E
---
N
----
P
A
L
A
V
A
I
K
T
C
K
N
--
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
--
E
N
--------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
--
Q
V
R
K
-----
Y
-
S
---------------------
L
D
--
L
-
A
S
---------
L
-----
I
L
Y
A
Y
-
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
S
----------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
----
L
K
A
Q
L
S
T
I
L
E
E
E
K
A
Q
Q
E
--------------------------------------------------------------------------------
59
Blastp_CBE
57.97
46%
-66
- C5 -
-
4DEG
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
----------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
444
Blastp_CBE
57.96
40%
7
- C5 -
-
5A46
2
B:
[22-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
V
S
E
Y
E
L
P
E
D
P
R
-
W
E
L
--
P
R
D
R
L
V
L
--
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
---
E
AIG
L
------
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-----
P
P----------------------------
H
N
PEEQLSSKD
L
-----
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
17
PsiBlast_PDB
57.90
61%
-169
- C5 -
-
4FF8
1
A:
[80-297]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
E
F
-
D
H
P
H
V
A
K
L
--------------------
V
I
L
P
F
M
K
H
G
D
L
H
A
F
L
--
L
A
S
R
-----
I
------------------------
P
--
L
-
Q
T
---------
L
-----
V
R
F
M
V
-
D
I
A
C
G
M
E
Y
L
S
S
R
N
F
I
H
R
D
L
A
A
R
N
C
M
L
A
---
E
D
M
T
V
C
V
A
-----------------------------
V
K
W
L
A
L
E
S
L
A
D
N
L
Y
T
V
H
S
D
V
W
A
F
G
V
T
M
W
E
I
M
T
R
-
G
Q
T
P
Y
A
G
I
E
N
A
E
I
Y
N
Y
L
I
G
-------
G
N
R
L
K
Q
P
P
E
C
M
--
V
Y
D
L
M
Y
Q
C
W
S
A
D
P
K
Q
R
P
S
F
T
C
----
L
R
M
E
L
E
N
I
L
----------------------------------------------------------------------------------------
251
Blastp_CBE
57.84
40%
-38
- C5 -
-
5E1S
1
A:
[16-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
S
R
E
K
I
T
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
ARD
I
-
I
---
K
G
---
E
----
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
G
Q
------
P
T
L
-
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
A
-
E
-----
N
--
N
P
G
R
---------
P
P
PT
L
-
Q
E
---------
M
-----
I
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
-----------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
----
I
V
N
L
L
K
D
D
L
----------------------------------------------------------------------------------------
125
Blastp_CBE
57.79
41%
-8
- C5 -
-
3NW5
1
A:
[15-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
M
-
E
-----
N
--
N
P
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
253
Blastp_CBE
57.62
40%
-22
- C5 -
-
3EKN
1
A:
[15-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
S
R
E
K
I
T
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
ARD
I
-
I
---
K
G
---
E
----
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
G
Q
------
P
T
L
-
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
A
-
E
-----
N
--
N
P
G
R
---------
P
P
PT
L
-
Q
E
---------
M
-----
I
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-----
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
----
I
V
N
L
L
K
D
D
L
----------------------------------------------------------------------------------------
408
Blastp_CBE
57.55
40%
-87
- C5 -
-
4JOA
1
A:
[45-327]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
------
V
Y
E
G
---
Q
---
V
-
S
---------------
L
Q
V
A
V
K
T
L
P
-----------
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-----------------------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
R
D
I
Y
----------------
A
M
L
P
V
K
W
M
P
P
E
A
---
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
128
Blastp_CBE
57.52
41%
-24
- C5 -
-
1JQH
1
C:
[16-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
------------------
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
-------
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
130
Blastp_CBE
57.48
41%
-24
- C5 -
-
1JQH
1
IGF1R_HUMAN
A:
[16-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
------------------
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
-------
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
53
Blastp_CBE
57.31
46%
-62
- C5 -
-
5EYD
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
----------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
--
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
46
Blastp_CBE
57.30
44%
-38
- C5 -
-
3VW8
1
A:
[32-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
L
N
P
-
E
L
V
Q
A
V
Q
H
V
V
I
GP
S
S
L
I
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S--------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
-----
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
131
Blastp_CBE
57.27
41%
-15
- C5 -
-
5FXR
1
A:
[16-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
-
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
M
-
E
-----
N
--
N
P
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
533
Blastp_CBE
57.26
41%
-8
- C5 -
-
4J99
1
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
-----
M
--
E
Y
S
Y
DQ-------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
T
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
248
Blastp_CBE
57.25
40%
-13
- C5 -
-
4IBM
1
?
A:
[14-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
S
R
E
K
I
T
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
ARD
I
-
I
---
K
G
---
E
----
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
G
Q
------
P
T
L
-
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
A
-
E
-----
N
--
N
P
G
R
---------
P
P
PT
L
-
Q
E
---------
M
-----
I
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
----
I
V
N
L
L
K
D
D
L
----------------------------------------------------------------------------------------
529
Blastp_CBE
57.22
41%
-1
- C5 -
-
5UI0
1
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
-----
M
--
E
Y
S
Y
DINRVPEEQ
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
M
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
124
Blastp_CBE
57.10
41%
-7
- C5 -
-
3NW6
1
A:
[15-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
M
-
E
-----
N
--
N
P
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
43
Blastp_CBE
57.07
46%
-60
- C5 -
-
4KNB
2
MET_HUMAN
C:
[19-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
-----------------
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
---------
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
539
Blastp_CBE
57.06
41%
-3
- C5 -
-
3RI1
1
?
A:
[23-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P-------------EQ-------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
538
Blastp_CBE
57.03
41%
-11
- C5 -
-
3RI1
1
FGFR2_HUMAN
B:
[23-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---------PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P-------------EQ-------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
492
Blastp_CBE
57.02
41%
-9
- C5 -
-
5UHN
1
FGFR2_HUMAN
A:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
--------------------EEQ------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
110
Blastp_CBE
57.00
41%
-9
- C5 -
-
3LW0
2
D:
[12-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P-----------------------------
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
247
Blastp_CBE
56.96
40%
-18
- C5 -
-
4IBM
1
?
B:
[14-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
S
R
E
K
I
T
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
ARD
I
-
I
---
K
G
---
E
----
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
-----------
P
T
L
-
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
A
-
E
-----
N
--
N
P
G
R
---------
P
P
PT
L
-
Q
E
---------
M
-----
I
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
----
I
V
N
L
L
K
D
D
L
----------------------------------------------------------------------------------------
537
Blastp_CBE
56.81
39%
-45
- C5 -
-
2JKM
1
A:
[3-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
I
--
Q
R
E
R
I
E
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I--
Y
---
M
-
S
---
P
E
---
N
----
P
A
M
A
V
A
I
K
T
C
K
N
--
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
--
E
N
--------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
--
Q
V
R
K
-----
Y
-
S
---------------------
L
D
--
L
-
A
S
---------
L
-----
I
L
Y
A
Y
-
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
S
R
---------------------
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
----
L
K
A
Q
L
S
T
I
L
E
---------------------------------------------------------------------------------------
87
Blastp_CBE
56.86
46%
-64
- C5 -
-
3CD8
1
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
----------------
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
------------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
---
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
113
Blastp_CBE
56.84
41%
-10
- C5 -
-
3LW0
2
IGF1R_HUMAN
A:
[12-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P-----------------------------
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
447
Blastp_CBE
56.81
40%
1
- C5 -
-
6P69
3
FGFR1_HUMAN
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-------P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
252
Blastp_CBE
56.76
40%
-21
- C5 -
-
5HHW
2
?
A:
[15-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
S
R
E
K
I
T
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
ARD
I
-
I
---
K
G
---
E
----
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
G
Q
------
P
T
L
-
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
A
-
E
-----
N
--
N
P
G
R
---------
P
P
PT
L
-
Q
E
---------
M
-----
I
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
----
I
V
N
L
L
K
D
D
L
----------------------------------------------------------------------------------------
528
Blastp_CBE
56.73
41%
2
- C5 -
-
5UGX
1
FGFR2_HUMAN
A:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
-----
M
--
E
Y
S
Y
DINRVPEEQ
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
440
Blastp_CBE
56.68
39%
1
- C5 -
-
6NEC
3
RET_HUMAN
A:
[22-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
K----
V
-
G
PGYLG-----
D
E
---------
R
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
Y
--
V
--
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
88
Blastp_CBE
56.68
46%
-67
- C5 -
-
3CCN
1
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
----------------
K
I
H
C
A
V
K
S
L
N
-
R
-----
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
---
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
111
Blastp_CBE
56.66
41%
-11
- C5 -
-
3LW0
3
IGF1R_HUMAN
C:
[12-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P-----------------------------
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
513
Blastp_CBE
56.64
39%
-40
- C5 -
-
4EBV
3
A:
[31-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
I
--
Q
R
E
R
I
E
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I--
Y
---
M
-
S
---
P
E
---
N
----
P
A
L
A
V
A
I
K
T
C
K
N
--
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
--
E
N
--------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
--
Q
V
R
K
-----
Y
-
S
---------------------
L
D
--
L
-
A
S
---------
L
-----
I
L
Y
A
Y
-
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
----------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
----
L
K
A
Q
L
S
T
I
L
E
---------------------------------------------------------------------------------------
123
Blastp_CBE
56.63
41%
-13
- C5 -
-
3NW7
1
A:
[15-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
M
-
E
-----
N
--
N
P
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
112
Blastp_CBE
56.61
41%
-10
- C5 -
-
3LW0
3
IGF1R_HUMAN
B:
[12-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
--
R
S
L
R
P-----------------------------
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
242
Blastp_CBE
56.60
40%
-13
- C5 -
-
3ETA
1
B:
[13-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
S
R
E
K
I
T
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
ARD
I
-
I
---
K
G
---
E
----
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
G
Q
------
P
T
L
-
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
A
-
E
-----
N
--
N
P
G
R
---------
P
P
PT
L
-
Q
E
---------
M
-----
I
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
--
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
----
I
V
N
L
L
K
D
D
L
----------------------------------------------------------------------------------------
324
Blastp_CBE
56.34
40%
-20
- C5 -
-
4FNZ
1
A:
[28-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
---
V
-
S
G------------
S
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----
S
--
Q
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
---------------------
G
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
550
HHSearch
56.31
41%
-14
- C5 -
-
5FM3
1
A:
[60-352]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
--
P
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
---
T
---
A
-
F
---
H
L
KGR
A
----
G
Y
T
T
V
A
V
K
M
L
K
E
N
-
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
--------------------
A
---------
L
T
--
M
-
G
D
---------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
Y
--
V
--
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
V
---------------------------------------------------------------------------------------
505
Blastp_CBE
56.30
41%
1
- C5 -
-
2PWL
1
FGFR2_HUMAN
A:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
--------------EQ-------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
137
Blastp_CBE
56.28
41%
-18
- C5 -
-
5FXQ
1
A:
[16-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
-
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
M
----------
N
P
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-----
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
536
Blastp_CBE
56.14
41%
2
- C5 -
-
5UGL
1
A:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
---------------------RVPEEQ---
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
442
Blastp_CBE
56.14
39%
-2
- C5 -
-
2IVS
5
RET_HUMAN
A:
[22-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
K----
V
-
G
PGYL-----------------
R
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
Y
--
V
--
K
R
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
261
Blastp_CBE
56.16
40%
-33
- C5 -
-
1I44
1
A:
[14-290]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
S
R
E
K
I
T
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
ARD
I
-
I
---
K
G
---
E
----
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
G
Q
------
P
T
L
-
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
A
-
E
-----
N
--
N
P
G
R
---------
P
P
PT
L
-
Q
E
---------
M
-----
I
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
----------------------
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
----
I
V
N
L
L
K
D
D
L
----------------------------------------------------------------------------------------
512
Blastp_CBE
56.15
39%
-41
- C5 -
-
4EBW
1
A:
[31-299]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
Y
E
I
--
Q
R
E
R
I
E
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I--
Y
---
M
-
S
--------
N
----
P
A
L
A
V
A
I
K
T
C
K
N
--
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
--
E
N
--------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
--
Q
V
R
K
-----
Y
-
S
---------------------
L
D
--
L
-
A
S
---------
L
-----
I
L
Y
A
Y
-
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
----------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
----
L
K
A
Q
L
S
T
I
L
E
---------------------------------------------------------------------------------------
129
Blastp_CBE
56.14
41%
-23
- C5 -
-
1JQH
1
IGF1R_HUMAN
B:
[16-293]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
-------------------------------
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
-------
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
468
Blastp_CBE
56.11
41%
5
- C5 -
-
4J98
1
FGFR2_HUMAN
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
-----
M
--
E
Y
S
Y
DINRVPEEQ
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
Q
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
368
Blastp_CBE
56.04
40%
6
- C5 -
-
4V05
3
B:
[19-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
-----P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PP---------------------------------
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
----
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
---------------------------------------------------------------------------------
254
Blastp_CBE
56.04
40%
-36
- C5 -
-
3EKK
1
A:
[15-291]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
S
R
E
K
I
T
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
ARD
I
-
I
---
K
G
---
E
----
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
G
Q
------
P
T
L
-
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
A
-
E
-----
N
--
N
P
G
R
---------
P
P
PT
L
-
Q
E
---------
M
-----
I
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
N
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
------------------------
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
N
M
R
P
T
F
L
E
----
I
V
N
L
L
K
D
D
L
----------------------------------------------------------------------------------------
95
Blastp_CBE
56.03
46%
-62
- C5 -
-
5UAB
2
A:
[61-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
------------------
H
C
A
V
K
S
L
N
--------
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
89
Blastp_CBE
56.03
46%
-67
- C5 -
-
2RFS
1
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
----------------
K
I
H
C
A
V
K
S
L
N
-----
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
-----------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
417
Blastp_CBE
56.00
40%
11
- C5 -
-
3JS2
1
FGFR1_HUMAN
A:
[27-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPGL---------------
H
---------
N
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
504
Blastp_CBE
55.97
41%
-4
- C5 -
-
2PWL
1
FGFR2_HUMAN
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
------------EQ-------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
114
Blastp_CBE
55.94
42%
-13
- C5 -
-
3QQU
1
D:
[9-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
M
-------------
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
IISS
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
94
Blastp_CBE
55.88
46%
-64
- C5 -
-
5UAD
1
A:
[61-316]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
------------------
H
C
A
V
K
S
L
N
-----
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
146
Blastp_CBE
55.76
42%
-14
- C5 -
-
3LVP
1
IGF1R_HUMAN
C:
[44-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
------------------
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
--
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
IISS
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
445
Blastp_CBE
55.73
40%
14
- C5 -
-
5A46
4
FGFR1_HUMAN
A:
[28-329]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
E
D
P
R
-
W
E
L
--
P
R
D
R
L
V
L
--
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-----
P
P
G
-----
L
-----------------------EEQLSSKD-
L
-----
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
73
Blastp_CBE
55.72
46%
-20
- C5 -
-
3RHK
1
MET_HUMAN
A:
[50-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
423
Blastp_CBE
55.71
41%
-7
- C5 -
-
3GQL
1
C:
[27-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-----
P
P-------------EQ-------
L
S
--
S
-
K
D
---------
L
-----
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
527
Blastp_CBE
55.65
41%
1
- C5 -
-
5UGX
1
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
-----
M
------INRVPEEQ-
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
----------------
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
425
Blastp_CBE
55.67
41%
-7
- C5 -
-
3GQL
1
FGFR1_HUMAN
A:
[27-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-----
P
P-------------EQ-------
L
S
--
S
-
K
D
---------
L
-----
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
------------------
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
243
Blastp_CBE
55.65
40%
-14
- C5 -
-
3ETA
1
INSR_HUMAN
A:
[13-289]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
S
R
E
K
I
T
L
--
L
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
N
ARD
I
-
I
---
K
G
---
E
----
A
E
T
R
V
A
V
K
T
V
N
E
S
A
S
L
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
G
F
-
T
C
H
H
V
V
R
L
L
G
V
V
S
--
K
G
Q
------
P
T
L
-
V
V
M
E
L
M
A
H
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
A
-
E
-----
N
--
N
P
G
R
---------
P
P
PT
L
-
Q
E
---------
M
-----
I
Q
M
A
A
-
E
I
A
D
G
M
A
Y
L
N
A
K
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
H
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
-
G
K
G
L
L
P
V
R
W
M
A
P
E
S
L
K
D
G
V
F
T
T
S
S
D
M
W
S
F
G
V
V
L
W
E
I
T
S
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
K
F
V
M
D
-------
G
G
Y
L
D
Q
P
D
N
C
P
E
R
V
T
D
L
M
R
M
C
W
Q
F
N
P
K
M
R
P
T
F
L
E
----
I
V
N
L
L
K
D
D
L
----------------------------------------------------------------------------------------
147
Blastp_CBE
55.62
42%
-12
- C5 -
-
3LVP
1
IGF1R_HUMAN
B:
[44-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
------------------
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
IISS
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
390
Blastp_CBE
55.57
41%
-1
- C5 -
-
3C4F
1
B:
[12-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-----
P
-------------------------------PEEQLSSKD
L
-----
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
424
Blastp_CBE
55.55
41%
-3
- C5 -
-
3GQL
1
FGFR1_HUMAN
B:
[27-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-----
P
P-------------PEEQ-----
L
S
--
S
-
K
D
---------
L
-----
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
----------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
437
Blastp_CBE
55.48
40%
-12
- C5 -
-
5ZV2
1
B:
[16-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-------------------------------------PEEQLSSKD
L
-----
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-------
D
Y
--
Y
--
K
--
K
T
---
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
----------------------------------------------------------------------------------------
391
Blastp_CBE
55.47
41%
-1
- C5 -
-
3C4F
1
FGFR1_HUMAN
A:
[12-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-----
P
-------------------------------PEEQLSSKD
L
-----
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
115
Blastp_CBE
55.44
42%
-13
- C5 -
-
3QQU
1
IGF1R_HUMAN
C:
[9-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
M
------------
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
IISS
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
126
Blastp_CBE
55.37
41%
-3
- C5 -
-
2OJ9
1
A:
[15-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
------------------------------
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
118
Blastp_CBE
55.32
42%
-7
- C5 -
-
3I81
1
A:
[15-292]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
-------
E
-----
N
--
N
P
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
-------
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
IISS
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
521
Blastp_CBE
55.24
41%
-2
- C5 -
-
4J95
1
FGFR2_HUMAN
A:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
--------------Q--------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
----
Y
--
Y
--
K
--
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
116
Blastp_CBE
55.22
42%
-9
- C5 -
-
3QQU
1
IGF1R_HUMAN
B:
[9-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
-----------------------------------
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
IISS
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
486
Blastp_CBE
55.17
39%
-39
- C5 -
-
4I4F
2
A:
[10-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
E
I
--
Q
R
E
R
I
E
L
--
G
R
C
I
G
E
G
Q
F
G
D
V
H
Q
G
I--
Y
---
M
-
S
-------------
P
A
L
A
V
A
I
K
T
C
K
N
--
C
T
S
D
S
V
R
E
K
F
L
Q
E
A
L
T
M
R
Q
F
-
D
H
P
H
I
V
K
L
I
G
V
I
T
--
E
N
--------
P
V
W
I
I
M
E
L
C
T
L
G
E
L
R
S
F
L
--
Q
V
R
K
-----
Y
-
S
---------------------
L
D
--
L
-
A
S
---------
L
-----
I
L
Y
A
Y
-
Q
L
S
T
A
L
A
Y
L
E
S
K
R
F
V
H
R
D
I
A
A
R
N
V
L
V
S
---
S
N
D
C
V
K
L
G
D
F
G
L
S
---------------------
K
L
P
I
K
W
M
A
P
E
S
I
N
F
R
R
F
T
S
A
S
D
V
W
M
F
G
V
C
M
W
E
I
L
M
H
-
G
V
K
P
F
Q
G
V
K
N
N
D
V
I
G
R
I
E
N
-------
G
E
R
L
P
M
P
P
N
C
P
P
T
L
Y
S
L
M
T
K
C
W
A
Y
D
P
S
R
R
P
R
F
T
E
----
L
K
A
Q
L
S
T
I
L
E
---------------------------------------------------------------------------------------
39
Blastp_CBE
55.17
46%
-16
- C5 -
-
4R1V
4
A:
[24-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
--
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
514
Blastp_CBE
55.15
41%
-7
- C5 -
-
2PZ5
1
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
------
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P-------------EQ-------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
465
Blastp_CBE
54.99
40%
15
- C5 -
-
3TT0
1
FGFR1_HUMAN
A:
[68-358]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPGLE
Y
-
S
-----
Y
--
N
P
S
H
---------
N
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
495
Blastp_CBE
54.93
41%
11
- C5 -
-
4J97
1
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
---
G
Q
V
V
M
A
---
E
AVG
I
-
D
-------------
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
------------INRVPEEQ-
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
41
Blastp_CBE
54.93
46%
-13
- C5 -
-
2WD1
3
A:
[24-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
152
Blastp_CBE
54.92
41%
-7
- C5 -
-
3D94
1
A:
[9-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
-----------------------------------
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
----
I
I
S
S
I
K
E
E
M
E
---------------------------------------------------------------------------------------
519
Blastp_CBE
54.89
41%
5
- C5 -
-
4J95
1
?
C:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
--------------------Q--------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
452
Blastp_CBE
54.85
40%
27
- C5 -
-
5VND
10
FGFR1_HUMAN
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPGLE
Y
-
S
-----
Y
--
N
P
S
H
---------
N
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
439
Blastp_CBE
54.80
39%
-9
- C5 -
-
6NEC
1
C:
[22-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
K----
V
-------------
E
---------
R
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
---------------
S
Q
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
380
Blastp_CBE
54.80
40%
6
- C5 -
-
4NKA
2
B:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
------
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PP---------------------------------
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
------
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
376
Blastp_CBE
54.63
40%
16
- C5 -
-
4UWB
3
B:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
------
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPGLE
Y
-
S
-----
Y
-----
H
---------
N
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
---
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
336
Blastp_CBE
54.63
40%
0
- C5 -
-
5Z0S
1
FGFR1_HUMAN
A:
[18-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
------
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
-----------------------------------------------------------------------------------
138
Blastp_CBE
54.62
45%
-84
- C5 -
-
5HO6
1
A:
[15-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
--
C
V
Y
H
G
---
T
---
L
-----------------
I
H
C
A
V
K
S
----------
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
-----------
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
72
Blastp_CBE
54.61
46%
-16
- C5 -
-
3RHK
1
B:
[50-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
374
Blastp_CBE
54.60
40%
20
- C5 -
-
4UWC
9
B:
[19-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
------
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPGLE
Y
-
S
-----
Y
-----
H
---------
N
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
---------------------------------------------------------------------------------
364
Blastp_CBE
54.59
40%
15
- C5 -
-
5O49
1
B:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
-----P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPG--------------------------------
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
520
Blastp_CBE
54.56
41%
6
- C5 -
-
4J95
1
?
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
--------------Q--------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
N
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
531
Blastp_CBE
54.55
41%
7
- C5 -
-
4J99
1
?
D:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
--------------------Q--------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
T
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
441
Blastp_CBE
54.50
39%
-6
- C5 -
-
2IVS
3
B:
[22-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
K----------------------------
R
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
-----------------
G
R
I
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
145
Blastp_CBE
54.50
42%
-11
- C5 -
-
3LVP
2
D:
[44-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
-----------
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
------------------
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
---
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
IISS
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
117
Blastp_CBE
54.49
42%
-7
- C5 -
-
3QQU
1
IGF1R_HUMAN
A:
[9-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
--------------------------------
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
E
T
D
Y
--
Y
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
IISS
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
143
Blastp_CBE
54.48
45%
-85
- C5 -
-
5HOR
1
A:
[17-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
---
C
V
Y
H
G
---
T
---
L
----------------
K
I
H
C
A
V
K
S
----------
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
-------------------
L
P
V
K
W
T
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
540
Blastp_CBE
54.47
41%
-7
- C5 -
-
1OEC
1
A:
[26-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
C
F
G
Q
V
V
M
A
---
E
AVG
I
----------
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
--------------------EQ-------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
534
Blastp_CBE
54.45
41%
1
- C5 -
-
4J99
1
FGFR2_HUMAN
A:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
--------------Q--------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
--
D
Y
--
Y
--
K
----
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
322
Blastp_CBE
54.44
40%
-24
- C5 -
-
5IUH
1
A:
[28-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
-----
G
E
V
Y
E
G
---
Q
---
V
-
S
G-------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-----------
P
S
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
G
M
A
-------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
81
Blastp_CBE
54.40
46%
-15
- C5 -
-
2WKM
1
A:
[29-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
375
Blastp_CBE
54.37
40%
27
- C5 -
-
4UWC
9
FGFR1_HUMAN
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPGLE
Y
-
S
-----
Y
---
P
S
H
---------
N
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
348
Blastp_CBE
54.36
40%
-23
- C5 -
-
6C1C
1
B:
[21-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
---
E
AIG
L
------
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
----------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
----------------------------------------------------------------------------------
400
Blastp_CBE
54.19
40%
2
- C5 -
-
1FGI
1
FGFR1_HUMAN
A:
[20-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-------P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
-----------------------------------------------------------------------------------
67
Blastp_CBE
54.20
46%
-21
- C5 -
-
4MXC
1
A:
[51-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV-------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
76
Blastp_CBE
54.19
46%
-9
- C5 -
-
3ZZE
1
A:
[29-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
71
Blastp_CBE
54.14
46%
-17
- C5 -
-
5DG5
1
MET_HUMAN
A:
[50-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
70
Blastp_CBE
54.14
46%
-16
- C5 -
-
5DG5
1
B:
[50-305]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
335
Blastp_CBE
54.13
40%
6
- C5 -
-
5Z0S
1
B:
[18-304]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-------P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
------------------------------------------------------------------------------------
366
Blastp_CBE
54.12
40%
10
- C5 -
-
5EW8
1
B:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PP---------------------------------
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
--
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
334
Blastp_CBE
54.03
40%
10
- C5 -
-
6ITJ
1
?
A:
[18-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
93
Blastp_CBE
54.03
46%
-28
- C5 -
-
6SDC
1
A:
[41-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L-----
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
--
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
V
M
Y
D
K
E
Y
--
Y
SV-------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
370
Blastp_CBE
54.02
40%
7
- C5 -
-
4V04
6
B:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PP---------------------------------
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
77
Blastp_CBE
53.98
46%
-15
- C5 -
-
3ZXZ
1
A:
[29-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L--------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
148
Blastp_CBE
53.95
42%
-15
- C5 -
-
3LVP
2
IGF1R_HUMAN
A:
[44-321]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
M
-
E
---------
P
V
L
---------
A
P
--
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
-------------
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
F
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
IISS
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
494
Blastp_CBE
53.94
41%
8
- C5 -
-
4J97
1
?
C:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
---
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
-------------
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P-------------INRVPEEQ-
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
E
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
140
Blastp_CBE
53.93
45%
-88
- C5 -
-
5HNI
1
MET_HUMAN
X:
[15-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
-
G
C
V
Y
H
G
---
T
---
L
----------------
K
I
H
C
A
V
K
S
----------
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
----------------------
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
289
Blastp_CBE
53.92
43%
-43
- C5 -
-
2GQG
2
ABL1_HUMAN
B:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
T
--
A
--
H
--
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
524
Blastp_CBE
53.82
41%
3
- C5 -
-
2PVY
1
?
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
------
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
------------DINRVPEEQ
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
--
Y
--
Y
--
K
------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
371
Blastp_CBE
53.82
40%
6
- C5 -
-
4V04
6
FGFR1_HUMAN
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
---
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPGLE
Y
-
S
---------
P
S
H
---------
N
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
399
Blastp_CBE
53.83
40%
-4
- C5 -
-
1FGI
1
B:
[20-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-------P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
------------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
--
Y
--
K
--
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
------------------------------------------------------------------------------------
82
Blastp_CBE
53.82
46%
-11
- C5 -
-
2WGJ
1
A:
[29-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L--------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
80
Blastp_CBE
53.82
46%
-14
- C5 -
-
3ZBX
1
A:
[29-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L--------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
48
Blastp_CBE
53.78
46%
-15
- C5 -
-
3F66
4
MET_HUMAN
A:
[27-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L---------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV-------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
75
Blastp_CBE
53.76
46%
-15
- C5 -
-
4AOI
1
A:
[29-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L--------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
139
Blastp_CBE
53.75
45%
-88
- C5 -
-
5HNI
1
Y:
[15-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
-
G
C
V
Y
H
G
---
T
---
L
----------------
K
I
H
C
A
V
K
S
----------
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
----------------------
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
434
Blastp_CBE
53.61
40%
-0
- C5 -
-
6NVL
1
FGFR1_HUMAN
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
C
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PP----------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
--------
Y
--
Y
--
K
--
K
-
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
384
Blastp_CBE
53.59
40%
9
- C5 -
-
4F65
4
B:
[19-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
-----P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
-------
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
----------------------------------------------------------------------------------
74
Blastp_CBE
53.55
46%
-16
- C5 -
-
4AP7
1
A:
[29-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L--------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
387
Blastp_CBE
53.51
40%
-0
- C5 -
-
4F64
3
FGFR1_HUMAN
A:
[19-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
-----
G
Q
V
V
L
A
---
E
AIG
L
-------P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
-----------------------------------------------------------------------------------
79
Blastp_CBE
53.53
46%
-14
- C5 -
-
3ZC5
1
A:
[29-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L--------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
256
Blastp_CBE
53.51
43%
-47
- C5 -
-
3DK7
1
ABL1_MOUSE
A:
[8-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
-------
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
T
--
A
--
H
--
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
383
Blastp_CBE
53.49
40%
7
- C5 -
-
4NK9
5
FGFR1_HUMAN
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
----
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PP---------------------------------
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
535
Blastp_CBE
53.40
41%
-3
- C5 -
-
5UGL
1
?
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
-----------------------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
V
I
-----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
78
Blastp_CBE
53.39
46%
-14
- C5 -
-
3ZCL
1
A:
[29-284]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L--------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
66
Blastp_CBE
53.37
46%
-19
- C5 -
-
5EOB
1
A:
[51-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV-----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
332
Blastp_CBE
53.33
40%
6
- C5 -
-
3RHX
5
FGFR1_HUMAN
A:
[16-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
---------------------------------------------------------------------------------
290
Blastp_CBE
53.31
43%
-44
- C5 -
-
2GQG
2
ABL1_HUMAN
A:
[15-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
T
--
A
--
H
--
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
65
Blastp_CBE
53.25
46%
-18
- C5 -
-
5HTI
1
A:
[51-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV-------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
367
Blastp_CBE
53.24
40%
23
- C5 -
-
5EW8
1
FGFR1_HUMAN
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPG------------------------------
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
508
Blastp_CBE
53.20
41%
8
- C5 -
-
2PZP
1
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
------
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
E
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
------------EEQ------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
339
Blastp_CBE
53.19
40%
-12
- C5 -
-
4FNY
1
A:
[28-310]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
P
R
K
N
I
T
L
--
I
R
G
L
G
H
---
G
E
V
Y
E
G
---
Q
---
V
-
S
G-------------
P
L
Q
V
A
V
K
T
L
P
-
E
V
C
S
E
Q
D
E
-
L
D
F
L
M
E
A
L
I
I
S
K
F
-
N
H
Q
N
I
V
R
C
I
G
V
S
L
--
Q
S
L
P
R
------
F
-
I
L
L
E
L
M
A
G
G
D
L
K
S
F
L
--
R
E
T
R
P----
R
-
P
-----------
S
---------
L
A
--
M
-
L
D
---------
L
-----
L
H
V
A
R
-
D
I
A
C
G
C
Q
Y
L
E
E
N
H
F
I
H
R
D
I
A
A
R
N
C
L
L
T
CPG
P
G
R
V
A
K
I
G
D
F
----------------------
C
A
M
L
P
V
K
W
M
P
P
E
A
F
M
E
G
I
F
T
S
K
T
D
T
W
S
F
G
V
L
L
W
E
I
F
S
L
-
G
Y
M
P
Y
P
S
K
S
N
Q
E
V
L
E
F
V
T
S
-------
G
G
R
M
D
P
P
K
N
C
P
G
P
V
Y
R
I
M
T
Q
C
W
Q
H
Q
P
E
D
R
P
N
F
A
I
----
I
L
E
R
I
E
Y
C
------
T
Q
D
P
D
-
V
I
---------------------------------------------------------------------------
92
Blastp_CBE
53.18
46%
-21
- C5 -
-
6SDD
2
A:
[41-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
--
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
--------
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
V
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
331
Blastp_CBE
53.15
40%
-5
- C5 -
-
3RHX
2
B:
[16-302]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-------P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
------------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
------------------------------------------------------------------------------------
54
Blastp_CBE
53.12
46%
-14
- C5 -
-
5EYC
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L---------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
516
Blastp_CBE
53.07
41%
13
- C5 -
-
2PY3
1
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
----
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
-----
P
P
G
------------EEQ------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
55
Blastp_CBE
53.02
46%
-15
- C5 -
-
4XYF
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L---------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
344
Blastp_CBE
52.98
40%
-9
- C5 -
-
6MZQ
1
B:
[21-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
---
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
-----------------------------------------------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
------------------------------------------------------------------------------------
377
Blastp_CBE
52.95
40%
26
- C5 -
-
4UWB
4
FGFR1_HUMAN
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPGLE
Y
-
S
---------
P
S
H
---------
N
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
-
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
491
Blastp_CBE
52.82
41%
3
- C5 -
-
5UHN
2
B:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
H
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
A
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
--------------------Q--------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
60
Blastp_CBE
52.82
46%
-7
- C5 -
-
3U6I
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
518
Blastp_CBE
52.77
41%
3
- C5 -
-
4J95
2
?
D:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
--------------------Q--------
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
-----------------
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
438
Blastp_CBE
52.75
40%
11
- C5 -
-
5ZV2
1
FGFR1_HUMAN
A:
[16-299]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-----
P
-------------------------------EQLSSKD--
L
-----
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
--
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
----------------------------------------------------------------------------------------
51
Blastp_CBE
52.74
46%
-20
- C5 -
-
3LQ8
1
A:
[30-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
-----------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
--
D
K
E
Y
--
Y
S--------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
449
Blastp_CBE
52.68
40%
11
- C5 -
-
6P68
1
FGFR1_HUMAN
B:
[19-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
C
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
------------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
---
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
----------------------------------------------------------------------------------
352
Blastp_CBE
52.56
40%
-14
- C5 -
-
6C19
1
B:
[21-308]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
---
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
-----------------------------------
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
-----------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
-----------------------------------------------------------------------------------
357
Blastp_CBE
52.51
40%
14
- C5 -
-
5UR1
1
FGFR1_HUMAN
A:
[21-311]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
-
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PP-----------
Y
--
N
P
S
H
---------
N
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
------------------------
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
61
Blastp_CBE
52.51
46%
-13
- C5 -
-
3U6H
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
-------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
372
Blastp_CBE
52.35
40%
1
- C5 -
-
4V01
6
B:
[19-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
--
G
Q
V
V
L
A
---
E
AIG
L
-
D
-----P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
----------------------------------------------------------------------------------
517
Blastp_CBE
52.34
41%
6
- C5 -
-
2PY3
1
FGFR2_HUMAN
A:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
----
F
G
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
G
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
--------------------PEEQ-----
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
50
Blastp_CBE
52.32
46%
-23
- C5 -
-
6SD9
1
MET_HUMAN
A:
[41-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
-----
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
-----
E
Y
--
Y
S------
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
141
Blastp_CBE
52.27
45%
-12
- C5 -
-
1R0P
1
A:
[30-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
--------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
DS
V
--
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
------
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
388
Blastp_CBE
52.22
40%
-2
- C5 -
-
4F63
3
B:
[19-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
---
E
AIG
L
-------P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
------------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
--
Y
--
K
--
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
------------------------------------------------------------------------------------
464
Blastp_CBE
52.19
40%
-12
- C5 -
-
3TT0
4
B:
[68-356]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
------------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
-----------------------
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
----------------------------------------------------------------------------------
330
Blastp_CBE
52.17
40%
14
- C5 -
-
5AM7
1
FGFR1_HUMAN
A:
[20-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
---
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPG---------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
---------------------------------------------------------------------------------
68
Blastp_CBE
52.08
46%
-13
- C5 -
-
4GG7
1
A:
[51-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
150
Blastp_CBE
52.07
42%
-6
- C5 -
-
3DKG
1
A:
[33-311]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
------
C
V
Y
H
G
---
T
---
L
L
D
-------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
V
S
R
I
S
A
I
F
S
T
F
I
G
E
H
Y
V
H
V
N
A
T
Y
-------------------------------------------------------------------------
515
Blastp_CBE
52.00
41%
11
- C5 -
-
2PZ5
1
FGFR2_HUMAN
A:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
------
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
K
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
T
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
--------------------PEEQ-----
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
395
Blastp_CBE
51.98
40%
23
- C5 -
-
5AM6
1
FGFR1_HUMAN
A:
[20-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
---
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPG------------------------------
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
62
Blastp_CBE
52.01
46%
-17
- C5 -
-
3I5N
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
-----
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
-------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
260
Blastp_CBE
52.00
43%
-45
- C5 -
-
3DK6
1
ABL1_MOUSE
A:
[8-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
--
G
Q
F
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
--------
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
T
--
A
--
H
--
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
----------------------------------------------------------------------------------
63
Blastp_CBE
51.99
46%
-8
- C5 -
-
4EEV
1
A:
[49-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
-----------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
373
Blastp_CBE
51.95
40%
5
- C5 -
-
4V01
6
FGFR1_HUMAN
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
----
G
Q
V
V
L
A
---
E
AIG
L
------
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PP----------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
--------
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
44
Blastp_CBE
51.98
46%
-22
- C5 -
-
4KNB
2
MET_HUMAN
B:
[19-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L---------------
K
I
H
C
A
V
K
S
-------
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
-------------
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV---------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
84
Blastp_CBE
51.95
46%
-8
- C5 -
-
3EFK
1
MET_HUMAN
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
--------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
57
Blastp_CBE
51.95
46%
-10
- C5 -
-
4DEI
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
--------------
K
I
H
C
A
V
K
S
L
N
-
R
---
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
386
Blastp_CBE
51.92
40%
-2
- C5 -
-
4F64
3
B:
[19-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
-------P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
------------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
--
Y
--
K
--
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
------------------------------------------------------------------------------------
389
Blastp_CBE
51.84
40%
3
- C5 -
-
4F63
3
FGFR1_HUMAN
A:
[19-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
-----
G
Q
V
V
L
A
---
E
AIG
L
-------P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
D
I
H
H
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
-----------------------------------------------------------------------------------
282
Blastp_CBE
51.82
42%
-40
- C5 -
-
2V7A
1
ABL1_HUMAN
B:
[11-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
T
--
A
--
H
--
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
----------------------------------------------------------------------------------
255
Blastp_CBE
51.79
43%
-43
- C5 -
-
3DK7
1
ABL1_MOUSE
B:
[8-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
----
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
T
--
A
--
H
--
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
---------------------------------------------------------------------------------------
283
Blastp_CBE
51.75
42%
-39
- C5 -
-
2V7A
1
ABL1_HUMAN
A:
[11-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
L
G
G
G
Q
Y
G
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
K
E
D
T
M
---
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
I
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
N
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
T
--
A
--
H
--
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
L
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
----------------------------------------------------------------------------------
385
Blastp_CBE
51.65
40%
1
- C5 -
-
4F65
5
FGFR1_HUMAN
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
F
G
Q
V
V
L
A
---
E
AIG
L
------
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PP----------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
----------
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
259
Blastp_CBE
51.64
43%
-37
- C5 -
-
3DK6
1
ABL1_MOUSE
B:
[8-276]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
--
E
R
T
D
I
T
M
--
K
H
K
-------
E
V
Y
E
G
---
V
---
W
-
K
---
K
Y
---
S
------
L
T
V
A
V
K
T
L
--------
E
V
-
E
E
F
L
K
E
A
A
V
M
K
E
I
-
K
H
P
N
L
V
Q
L
L
G
V
C
------
T
R
E
--
P
P
F
Y
-
I
I
T
E
F
M
T
Y
G
N
L
L
D
Y
L
----
R
E
-----
C
-
N
-----
R
--
Q
E
V
--------------
S
-
A
V
---------
V
-----
L
L
Y
M
A
T
Q
I
S
S
A
M
E
Y
L
E
K
K
N
F
I
H
R
D
L
A
A
R
N
C
L
V
G
---
E
N
H
L
V
K
V
A
D
F
G
L
S
R
L
M
T
G
D
T
T
--
A
--
H
--
A
G
--
A
K
F
P
I
K
W
T
A
P
E
S
L
A
Y
N
K
F
S
I
K
S
D
V
W
A
F
G
V
L
L
W
E
I
A
T
Y
-
G
M
S
P
Y
P
G
I
D
P
S
Q
V
Y
E
L
L
E
K
-------
D
Y
R
M
E
R
P
E
G
C
P
E
K
V
Y
E
L
M
R
A
C
W
Q
W
N
P
S
D
R
P
S
F
A
E
----
I
H
Q
A
F
E
T
M
F
Q
E
S
S
I
S
D
E
V
-------------------------------------------------------------------------------
509
Blastp_CBE
51.63
41%
11
- C5 -
-
2PZP
1
FGFR2_HUMAN
A:
[34-317]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
K
L
T
L
--
G
K
P
L
------
Q
V
V
M
A
---
E
AVG
I
-
D
---
K
D
---
K
PK--
E
A
V
T
V
A
V
K
M
L
K
D
D
-
A
T
E
E
D
L
-
S
D
L
V
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
R
A
R
R
--------------------PEEQ-----
M
T
--
F
-
K
D
---------
L
-----
V
S
C
T
Y
-
Q
L
A
R
G
M
E
Y
L
A
S
Q
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
N
N
V
M
K
I
A
D
F
G
L
A
R
D
I
N
N
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
V
Y
T
H
Q
S
D
V
W
S
F
G
V
L
M
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
I
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
A
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
L
----------------------------------------------------------------------------------------
45
Blastp_CBE
51.61
46%
-15
- C5 -
-
4KNB
3
MET_HUMAN
A:
[19-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L---------------
K
I
H
C
A
V
K
S
L
----
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
329
Blastp_CBE
51.48
40%
15
- C5 -
-
5AM7
1
B:
[20-307]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
---
G
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
M
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PPG---------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
R
-----
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
-----------------------------------------------------------------------------------
136
Blastp_CBE
51.45
45%
-10
- C5 -
-
3CE3
1
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
502
Blastp_CBE
51.41
40%
1
- C5 -
-
2IVU
3
A:
[22-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
-----------------------------
R
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
RS
Q
G
R
I
---
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
142
Blastp_CBE
51.39
45%
-10
- C5 -
-
3A4P
3
A:
[37-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
-------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
--------------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
52
Blastp_CBE
51.38
46%
-11
- C5 -
-
5T3Q
1
?
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
--
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
--------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
83
Blastp_CBE
51.16
46%
-11
- C5 -
-
3EFK
1
B:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
--------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
69
Blastp_CBE
51.16
46%
-14
- C5 -
-
4GG5
1
A:
[51-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
-----
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
381
Blastp_CBE
51.13
40%
4
- C5 -
-
4NKA
3
FGFR1_HUMAN
A:
[19-309]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
----
Q
V
V
L
A
---
E
AIG
L
-
D
---
K
D
KP-
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
P-----------------------------
P
--
E
-
E
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
-------
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
N
Q
E
--------------------------------------------------------------------------------
378
Blastp_CBE
51.11
40%
1
- C5 -
-
4NKS
1
B:
[19-305]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
G
E
G
A
-
G
Q
V
V
L
A
---
E
AIG
L
-------P--
N
----
R
V
T
K
V
A
V
K
M
L
K
-
S
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
------------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
A
------
D
Y
--
Y
--
K
--
K
---
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
------------------------------------------------------------------------------------
121
Blastp_CBE
51.10
45%
-3
- C5 -
-
3QTI
1
MET_HUMAN
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
--------------
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
--------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
---
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
85
Blastp_CBE
51.09
46%
-6
- C5 -
-
3EFJ
1
B:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
49
Blastp_CBE
51.09
46%
-9
- C5 -
-
6SDE
1
A:
[41-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L---------------
K
I
H
C
A
V
K
S
L
N
-
R
I
----
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
--
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
86
Blastp_CBE
51.08
46%
-7
- C5 -
-
3EFJ
1
MET_HUMAN
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
--------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
135
Blastp_CBE
50.84
45%
-4
- C5 -
-
3CTH
1
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
64
Blastp_CBE
50.82
46%
-15
- C5 -
-
5YA5
1
A:
[51-306]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L--------------
K
K
I
H
C
A
V
K
S
L
N
-
R
--------
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
------------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
--
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
47
Blastp_CBE
50.82
46%
-13
- C5 -
-
3F66
3
B:
[27-282]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L--------------
K
K
I
H
C
A
V
K
S
L
N
-------
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
--------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
S--------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
379
Blastp_CBE
50.80
40%
6
- C5 -
-
4NKS
1
FGFR1_HUMAN
A:
[19-306]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
D
R
L
V
L
--
G
K
P
L
-----
G
Q
V
V
L
A
---
E
AI------------
N
----
R
V
T
K
V
A
V
K
M
L
K
--
D
A
T
E
K
D
L
-
S
D
L
I
S
E
M
E
M
M
K
M
I
G
K
H
K
N
I
I
N
L
L
G
A
C
T
--
Q
D
-------
G
P
L
Y
V
I
V
E
Y
A
S
K
G
N
L
R
E
Y
L
--
Q
A
R
R
PP----------------------------------
Q
---------
L
SSKDL
V
S
C
A
Y
-
Q
V
A
R
G
M
E
Y
L
A
S
K
K
C
I
H
R
D
L
A
A
R
N
V
L
V
T
---
E
D
N
V
M
K
I
A
D
F
G
L
------
I
D
Y
--
Y
--
K
--
K
T
T
N
G
R
L
P
V
K
W
M
A
P
E
A
L
F
D
R
I
Y
T
H
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
F
T
L
-
G
G
S
P
Y
P
G
V
P
V
E
E
L
F
K
L
L
K
E
-------
G
H
R
M
D
K
P
S
N
C
T
N
E
L
Y
M
M
M
R
D
C
W
H
A
V
P
S
Q
R
P
T
F
K
Q
----
L
V
E
D
L
D
R
I
V
-
A
L
T
S
-----------------------------------------------------------------------------------
144
Blastp_CBE
50.73
44%
-79
- C5 -
-
5HOA
1
A:
[17-285]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
F
--
N
E
V
I
-------
V
Y
H
G
---
T
---
L
----------------
K
I
H
C
A
V
K
--------------
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
-------------------
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
V
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
---------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
132
Blastp_CBE
50.65
45%
-1
- C5 -
-
3L8V
1
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
------------------
N
K
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
91
Blastp_CBE
50.65
46%
-7
- C5 -
-
2RFN
1
MET_HUMAN
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
----
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
40
Blastp_CBE
50.58
46%
-15
- C5 -
-
4R1Y
3
A:
[24-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L----------------
I
H
C
A
V
K
S
L
N
----------
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
-----------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
Y
--
Y
SV
H
----
T
G
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
99
Blastp_CBE
50.41
46%
-10
- C5 -
-
5HLW
1
A:
[22-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
-
H
F
G
C
V
Y
H
G
---
T
---
L
L-----
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
-
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
------------
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
H
D
K
E
Y
--
Y
SV-------
A
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
503
Blastp_CBE
50.26
40%
3
- C5 -
-
2IVT
3
A:
[22-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
K----
V
-----------------------
R
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
RS
Q
G
R
I
---
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
149
Blastp_CBE
50.23
45%
-8
- C5 -
-
3C1X
1
A:
[91-346]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
-------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
497
Blastp_CBE
50.04
40%
0
- C5 -
-
4CKJ
16
A:
[22-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
K----
V
-----------------------
R
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
RS
Q
G
R
I
---
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
120
Blastp_CBE
49.89
45%
-3
- C5 -
-
3QTI
1
B:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L--------------
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
------------
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
F
--------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
----
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
90
Blastp_CBE
49.78
46%
-4
- C5 -
-
2RFN
1
B:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
----
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
---------------------------
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
133
Blastp_CBE
49.50
45%
-7
- C5 -
-
3F82
1
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L---------------
K
I
H
C
A
V
K
S
L
N
-
R
----
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
-----------------------
K
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
306
Blastp_CBE
49.45
41%
-6
- C5 -
-
1K3A
1
A:
[7-284]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
--
A
R
E
K
I
T
M
--
S
R
E
L
G
Q
G
S
F
G
M
V
Y
E
G
---
V
---
A
-
K
GVV
K
D
---
E
----
P
E
T
R
V
A
I
K
T
V
N
E
A
A
S
M
R
E
R
I
-
E
-
F
L
N
E
A
S
V
M
K
E
F
-
N
C
H
H
V
V
R
L
L
G
V
V
S
--
Q
G
Q
------
P
T
L
-
V
I
M
E
L
M
T
R
G
D
L
K
S
Y
L
RS
L
R
P
E
-----
M
---------------------------
P
-
S
L
SK-------
M
-----
I
Q
M
A
G
-
E
I
A
D
G
M
A
Y
L
N
A
N
K
F
V
H
R
D
L
A
A
R
N
C
M
V
A
---
E
D
F
T
V
K
I
G
D
F
G
M
T
R
D
I
Y
--
E
T
--
D
--
R
--
K
G
G
K
G
L
L
P
V
R
W
M
S
P
E
S
L
K
D
G
V
F
T
T
Y
S
D
V
W
S
F
G
V
V
L
W
E
I
A
T
L
-
A
E
Q
P
Y
Q
G
L
S
N
E
Q
V
L
R
F
V
M
E
-------
G
G
L
L
D
K
P
D
N
C
P
D
M
L
L
E
L
M
R
M
C
W
Q
Y
N
P
K
M
R
P
S
F
L
E
IISS
I
K
E
E
M
E
-------------------------------------------------------------------------------------------
134
Blastp_CBE
49.43
45%
-12
- C5 -
-
3CTJ
1
A:
[32-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
F
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
-------------------------
L
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
501
Blastp_CBE
49.31
40%
5
- C5 -
-
2X2K
4
A:
[22-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
K----
V
-----------------------
R
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
RS
Q
G
R
I
---
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
467
Blastp_CBE
48.87
41%
3
- C5 -
-
6FEK
3
A:
[22-295]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
K----
V
-
G
-----
P
--
G
P
D
E
---------
R
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
F
V
--
K
--
R
S-
Q
G
R
I
---
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
500
Blastp_CBE
48.63
40%
11
- C5 -
-
2X2L
5
A:
[22-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
K----
V
-----------------------
R
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
RS
Q
G
R
I
---
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
499
Blastp_CBE
48.58
40%
-5
- C5 -
-
2X2M
3
RET_HUMAN
A:
[22-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
--
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
------------------------------
R
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
RS
Q
G
R
I
---
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
498
Blastp_CBE
48.22
40%
-4
- C5 -
-
2X2M
4
B:
[22-310]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
----
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
-------------------------------
A
--
L
-
T
M
GD-------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
Y
E
E
D
S
--
V
--
K
RS
Q
G
R
I
---
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
96
Blastp_CBE
47.77
45%
-40
- C5 -
-
4IWD
1
A:
[34-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
S
--
V
--
H
--
N
K
T
----
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
98
Blastp_CBE
47.63
45%
-16
- C5 -
-
3Q6W
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
S
--
V
--
H
--
N
K
T
----
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
97
Blastp_CBE
47.63
45%
-17
- C5 -
-
3R7O
1
A:
[31-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L
D
---
N
D
---
G
----
K
K
I
H
C
A
V
K
S
L
N
-
R
I
T
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
E
G
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
Y
D
K
E
S
--
V
--
H
--
N
K
T
----
P
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
Y
P
D
V
N
T
F
D
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
P
E
Y
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------
482
Blastp_CBE
46.93
41%
11
- C5 -
-
5AMN
7
A:
[22-296]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
K
N
L
V
L
--
G
K
T
L
G
E
G
E
F
G
K
V
V
K
A
TAF
H
---
L
-
K
---
G
R
---
A
----
G
Y
T
T
V
A
V
K
M
L
K
-
E
N
A
S
P
S
E
L
-
R
D
L
L
S
E
F
N
V
L
K
Q
V
-
N
H
P
H
V
I
K
L
Y
G
A
C
S
--
Q
D
G
------
P
L
L
-
L
I
V
E
Y
A
K
Y
G
S
L
R
G
F
L
--
R
E
S
R
-------
K
-----
V
------ERA------
L
T
--
M
-
G
D
---------
L
-----
I
S
F
A
W
-
Q
I
S
Q
G
M
Q
Y
L
A
E
M
K
L
V
H
R
D
L
A
A
R
N
I
L
V
A
---
E
G
R
K
M
K
I
S
D
F
G
L
S
R
D
V
E
E
D
S
V
--
K
--
R
S-
Q
G
R
I
---
P
V
K
W
M
A
I
E
S
L
F
D
H
I
Y
T
T
Q
S
D
V
W
S
F
G
V
L
L
W
E
I
V
T
L
-
G
G
N
P
Y
P
G
I
P
P
E
R
L
F
N
L
L
K
T
-------
G
H
R
M
E
R
P
D
N
C
S
E
E
M
Y
R
L
M
L
Q
C
W
K
Q
E
P
D
K
R
P
V
F
A
D
----
I
S
K
D
L
E
K
M
M
----------------------------------------------------------------------------------------
42
Blastp_CBE
45.94
46%
-9
- C5 -
-
4KNB
1
D:
[19-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
H
F
--
N
E
V
I
G
R
G
H
F
G
C
V
Y
H
G
---
T
---
L
L-----
D
---
G
----
K
K
I
H
C
A
V
K
S
L
-----
D
I
G
E
V
-
S
Q
F
L
T
E
G
I
I
M
K
D
F
-
S
H
P
N
V
L
S
L
L
G
I
C
L
--
R
-----
S
--
S
P
L
-
V
V
L
P
Y
M
K
H
G
D
L
R
N
F
I
-------------------
R
--
N
E
T
H
---------
N
P
--
T
V
K
D
---------
L
-----
I
G
F
G
L
-
Q
V
A
K
G
M
K
Y
L
A
S
K
K
F
V
H
R
D
L
A
A
R
N
C
M
L
D
---
E
K
F
T
V
K
V
A
D
F
G
L
A
R
D
M
---------------------
V
K
W
M
A
L
E
S
L
Q
T
Q
K
F
T
T
K
S
D
V
W
S
F
G
V
L
L
W
E
L
M
T
R
-
G
A
P
P
--------
I
T
V
Y
L
L
Q
-------
G
R
R
L
L
Q
---
C
P
D
P
L
Y
E
V
M
L
K
C
W
H
P
K
A
E
M
R
P
S
F
S
E
----
L
------------------------------------------------------------------------------------------------