@TOME V3
(Feb 2022)
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR3A2_ERb: (2019-08-20 )
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVNRETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGHNDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLHCAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDADSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMKCKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Atome Classification :
(68 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MDIKNSPSSLNSPSSYNCSQS
I
L
PLEHG
S
I
Y
I
P
S
S
YV
D
S
HHEYPA
M
T
F
YS
P
A
V
MNYSIPSNVTNLEGGPGRQTTSPNVLWPTPGH
L
S
P
L
V
V
H
R
Q
L
S
H
L
YAEPQKSPWCEARSLEHTLPV
N
R
E
T
L
K
R
KVSGNRCASPVTGPGSKRD
A
H
F
C
A
V
C
S
D
YASGYHYGVWS
C
E
G
C
K
A
F
F
K
R
SIQGHN
D
Y
ICPATN
Q
C
TIDKNRR
K
S
C
Q
A
C
R
L
R
K
C
Y
E
V
G
M
V
KCG
S
R
R
E
R
C
G
Y
R
L
V
R
R
QRSADE
Q
L
HCAGKAKRSGGH
A
P
R
V
R
E
L
L
L
D
AL
S
P
E
Q
L
V
L
T
L
LEAEPP
H
V
L
I
SRPSAPF
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
KIPG
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
RSIDHPG
K
L
I
FAPD
L
V
LDRDE
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
LNSSM
Y
P
L
V
T
ATQDAD
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
KSGI
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
HASNK
G
M
E
H
L
L
NMKCKNVV
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
G
C
K
SSITGSECSPAEDSKSKEGSQNPQSQ
64
Blastp_CBE
81.53
99%
-175
- C1 -
-
3OLL
1
ESR2_HUMAN
A:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
T
--
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
63
Blastp_CBE
80.25
99%
-180
- C1 -
-
3OLL
1
B:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
T
---
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
37
Blastp_CBE
76.42
100%
-176
- C1 -
-
4J24
1
ESR2_HUMAN
A:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
35
Blastp_CBE
75.16
100%
-180
- C1 -
-
4J24
1
ESR2_HUMAN
C:
[2-238]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
28
Blastp_CBE
74.82
99%
-176
- C1 -
-
5TOA
1
B:
[2-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
---------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
39
Blastp_CBE
73.09
100%
-178
- C1 -
-
3OMQ
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
34
Blastp_CBE
72.62
100%
-186
- C1 -
-
4J24
1
D:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
-------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
31
Blastp_CBE
71.84
100%
-180
- C1 -
-
1U3R
1
B:
[3-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
30
Blastp_CBE
71.62
100%
-181
- C1 -
-
1U9E
1
B:
[3-241]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-----------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
14
PsiBlast_PDB
70.06
100%
-178
- C1 -
-
1U3R
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
-------
Q
D
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
3
PsiBlast_PDB
70.00
100%
-178
- C1 -
-
1QKM
1
A:
[6-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-----
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
45
Blastp_CBE
69.50
100%
-175
- C1 -
-
3OLS
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
43
Blastp_CBE
68.13
100%
-175
- C1 -
-
3OMO
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
47
Blastp_CBE
67.97
100%
-178
- C1 -
-
2YJD
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
41
Blastp_CBE
67.68
100%
-175
- C1 -
-
3OMP
1
ESR2_HUMAN
A:
[4-237]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
-----
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
62
Blastp_CBE
66.63
99%
-188
- C1 -
-
2YLY
1
ESR2_HUMAN
A:
[2-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
------
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
36
Blastp_CBE
65.65
100%
-176
- C1 -
-
4J24
1
ESR2_HUMAN
B:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
4
PsiBlast_PDB
65.60
97%
-185
- C1 -
-
1L2J
1
ESR2_HUMAN
A:
[27-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
-----
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
----
L
V
T
A
T
Q
D
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
46
Blastp_CBE
65.39
100%
-178
- C1 -
-
2YJD
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
9
PsiBlast_PDB
64.95
99%
-175
- C1 -
-
4ZI1
1
A:
[2-242]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
-----------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
G
----------------------------
44
Blastp_CBE
64.93
100%
-181
- C1 -
-
3OLS
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
26
Blastp_CBE
64.88
100%
-186
- C1 -
-
2JJ3
1
B:
[12-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
--
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
15
PsiBlast_PDB
64.81
100%
-183
- C1 -
-
2GIU
1
A:
[1-241]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
-
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-----
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
----
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
53
Blastp_CBE
64.60
100%
-175
- C1 -
-
1U3S
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
--------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
10
PsiBlast_PDB
63.75
99%
-176
- C1 -
-
5TOA
1
ESR2_HUMAN
A:
[2-241]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
-
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
52
Blastp_CBE
62.88
100%
-175
- C1 -
-
1U3S
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
42
Blastp_CBE
62.76
100%
-180
- C1 -
-
3OMO
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
40
Blastp_CBE
62.68
100%
-181
* C1 *
-
3OMP
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
13
PsiBlast_PDB
61.57
100%
-177
- C1 -
-
1U9E
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
55
Blastp_CBE
61.54
100%
-179
- C1 -
-
1U3Q
1
ESR2_HUMAN
C:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
59
Blastp_CBE
61.28
99%
-177
- C1 -
-
1ZAF
1
B:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
A
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
38
Blastp_CBE
61.13
100%
-179
- C1 -
-
3OMQ
1
B:
[4-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
T
A
--------
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
-----------------------------------
20
PsiBlast_PDB
61.13
100%
-177
- C1 -
-
1U3Q
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
54
Blastp_CBE
60.36
100%
-179
- C1 -
-
1U3Q
1
D:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
---------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
33
Blastp_CBE
60.19
100%
-173
- C1 -
-
4J26
1
ESR2_HUMAN
A:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
----------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
2
PsiBlast_PDB
59.63
100%
-179
- C1 -
-
1YYE
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
18
PsiBlast_PDB
59.59
100%
-177
- C1 -
-
1X7B
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
32
Blastp_CBE
59.25
100%
-174
- C1 -
-
4J26
1
B:
[1-238]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
---------
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
58
Blastp_CBE
59.19
100%
-178
- C1 -
-
2NV7
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
22
Blastp_CBE
59.12
100%
-182
- C1 -
-
1YY4
1
B:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
19
PsiBlast_PDB
59.01
100%
-181
- C1 -
-
1X7J
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
11
PsiBlast_PDB
57.70
100%
-172
- C1 -
-
1NDE
1
A:
[15-254]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
--
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
----
A
T
Q
D
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
---
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
65
Blastp_CBE
56.68
92%
-180
- C1 -
-
2J7Y
7
A:
[8-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
S
-----
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
------
A
E
S
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
17
PsiBlast_PDB
56.52
100%
-176
- C1 -
-
1X78
1
ESR2_HUMAN
A:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
66
Blastp_CBE
56.10
92%
-178
- C1 -
-
2J7X
5
A:
[8-244]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
---
S
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
------
A
E
S
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
56
Blastp_CBE
55.63
100%
-180
- C1 -
-
1U3Q
1
ESR2_HUMAN
B:
[1-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
49
Blastp_CBE
55.42
100%
-175
- C1 -
-
1X7B
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
60
Blastp_CBE
54.27
99%
-173
- C1 -
-
1ZAF
1
ESR2_HUMAN
A:
[1-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
A
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
24
Blastp_CBE
53.75
100%
-181
- C1 -
-
2Z4B
1
B:
[12-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
48
Blastp_CBE
53.71
100%
-175
- C1 -
-
1X7J
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
16
PsiBlast_PDB
53.31
100%
-177
- C1 -
-
1X76
1
ESR2_HUMAN
A:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
25
Blastp_CBE
53.01
100%
-186
- C1 -
-
2QTU
1
B:
[12-252]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
------
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
6
PsiBlast_PDB
51.27
100%
-175
- C1 -
-
2JJ3
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
--
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
51
Blastp_CBE
50.98
100%
-174
- C1 -
-
1X76
1
B:
[3-237]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
5
PsiBlast_PDB
50.74
100%
-179
- C1 -
-
2I0G
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
50
Blastp_CBE
50.60
100%
-170
- C1 -
-
1X78
1
B:
[3-240]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
------------------------------
67
Blastp_CBE
49.93
91%
-182
- C1 -
-
1QKN
1
A:
[8-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
S
R
P
S
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
A
S
A
N
Q
E
A
E
S
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
--------
D
L
L
L
E
M
L
N
A
---------------------------------
57
Blastp_CBE
49.82
100%
-172
- C1 -
-
2NV7
1
B:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
27
Blastp_CBE
49.70
100%
-181
- C1 -
-
2I0G
1
B:
[12-250]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
61
Blastp_CBE
49.07
99%
-178
- C1 -
-
2YLY
1
B:
[1-238]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
------
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
------------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
23
Blastp_CBE
48.17
97%
-186
- C1 -
-
1L2J
1
ESR2_HUMAN
B:
[21-263]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
E
L
L
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
-------------
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
--
L
V
T
A
T
Q
D
A
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
-----
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
1
PsiBlast_PDB
47.86
100%
-175
- C1 -
-
1YY4
1
ESR2_HUMAN
A:
[1-235]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
---------------------------------
7
PsiBlast_PDB
47.67
100%
-180
- C1 -
-
2Z4B
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
----
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
21
Blastp_CBE
46.65
100%
-174
- C1 -
-
1YYE
1
B:
[1-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
----------
D
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
C
K
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
----------------------------------
8
PsiBlast_PDB
43.09
100%
-180
- C1 -
-
2QTU
1
ESR2_HUMAN
A:
[13-250]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
------
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
Y
P
L
V
-------
S
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
K
------
V
Y
D
L
L
L
E
M
L
N
A
H
--------------------------------
12
PsiBlast_PDB
41.33
98%
-173
- C1 -
-
2FSZ
2
ESR2_HUMAN
A:
[8-245]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
S
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
S
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
---
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
29
Blastp_CBE
39.44
99%
-172
- C1 -
-
2FSZ
2
B:
[4-245]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
A
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
H
V
L
I
S
R
P
S
A
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
S
W
A
K
K
I
P
G
F
V
E
L
S
L
F
D
Q
V
R
L
L
E
S
S
W
M
E
V
L
M
M
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
S
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
S
S
M
------------
S
R
K
L
A
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
M
R
L
A
N
L
L
M
L
L
S
H
V
R
H
A
S
N
K
G
M
E
H
L
L
N
M
---
N
V
V
P
V
Y
D
L
L
L
E
M
L
N
A
H
V
L
R
-----------------------------
68
Blastp_CBE
16.43
91%
-183
- C1 -
-
1HJ1
2
A:
[9-226]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
P
E
Q
L
V
L
T
L
L
E
A
E
P
P
N
V
L
V
S
R
P
S
M
P
F
T
E
A
S
M
M
M
S
L
T
K
L
A
D
K
E
L
V
H
M
I
G
W
A
K
K
I
P
G
F
V
E
L
S
L
L
D
Q
V
R
L
L
E
S
C
W
M
E
V
L
M
V
G
L
M
W
R
S
I
D
H
P
G
K
L
I
F
A
P
D
L
V
L
D
R
D
E
G
K
C
V
E
G
I
L
E
I
F
D
M
L
L
A
T
T
S
R
F
R
E
L
K
L
Q
H
K
E
Y
L
C
V
K
A
M
I
L
L
N
--------------
S
S
R
K
L
T
H
L
L
N
A
V
T
D
A
L
V
W
V
I
A
K
S
G
I
S
S
Q
Q
Q
S
V
R
L
A
N
L
L
M
L
L
S
H
V
R
H
I
S
N
K
G
M
E
H
L
L
S
M
K
--------------------------------------------------