@TOME V3
(Feb 2022)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR1C2_PPARb: (2021-05-27 )
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
Atome Classification :
(349 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
MEQP
Q
E
EAP
E
V
R
E
E
E
E
K
E
E
V
A
EAEGAPELNGGPQHALPSSSYTDLSRSSS
P
P
S
L
L
D
Q
L
Q
MGCDGASCGSL
N
M
E
C
R
V
CGDKASGF
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
M
K
L
E
Y
E
K
C
E
R
SCKIQKKNR
N
K
C
Q
Y
C
R
F
Q
K
C
L
A
LGMSHNAIRFGRMP
E
A
E
K
R
K
L
V
A
G
L
TANEGSQYNP
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
NFN
M
T
K
K
K
A
R
S
I
LTGKASHTA
P
F
V
I
H
D
I
E
T
L
W
Q
AEK
G
L
V
W
K
Q
L
VNGLPPY
K
E
I
S
V
H
V
F
Y
R
C
QC
T
T
V
E
T
V
R
E
L
T
E
F
A
K
SIP
S
F
S
S
L
F
LND
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
VNKD
G
L
L
V
ANGS
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
IEP
K
F
E
F
A
V
K
F
N
A
L
ELDD
S
D
L
A
L
F
I
A
A
I
I
LCGDRPGLMNVP
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
LQANHP
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
KTETE
T
S
L
H
P
L
L
Q
E
I
Y
K
DMY
82
Blastp_CBE
86.90
63%
-147
- C1 -
-
3E00
1
PPARG_HUMAN
D:
[49-419]
---------------------------------------------------------------------
M
A
I
E
C
R
V
C
G
D
K
A
S
G
F
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
D
R
C
D
L
N
C
R
I
H
K
K
S
R
N
K
C
Q
Y
C
R
F
Q
K
C
L
A
V
G
M
S
H
N
A
I
R
F
G
R
M
P
Q
A
E
K
E
K
L
L
A
E
I
S
S
D
-
I
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
--------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
74
Blastp_CBE
82.73
100%
-172
- C1 -
-
3SP9
1
PPARD_HUMAN
A:
[13-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
84
Blastp_CBE
81.81
63%
-149
- C1 -
-
3DZU
1
PPARG_HUMAN
D:
[50-419]
----------------------------------------------------------------------
A
I
E
C
R
V
C
G
D
K
A
S
G
F
H
Y
G
V
H
A
C
E
G
C
K
G
F
F
R
R
T
I
R
L
K
L
I
Y
D
R
C
D
L
N
C
R
I
H
K
K
S
R
N
K
C
Q
Y
C
R
F
Q
K
C
L
A
V
G
M
S
H
N
A
I
R
F
G
R
M
P
Q
A
E
K
E
K
L
L
A
E
I
S
S
D
-
I
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
72
Blastp_CBE
81.09
99%
-160
- C1 -
-
5U3T
10
PPARD_HUMAN
A:
[1-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
12
PsiBlast_PDB
80.98
100%
-164
- C1 -
-
5U3R
12
PPARD_HUMAN
A:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
20
PsiBlast_PDB
80.94
100%
-157
- C1 -
-
5U42
8
PPARD_HUMAN
A:
[1-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
51
Blastp_CBE
80.93
100%
-164
- C1 -
-
3GWX
1
PPARD_HUMAN
A:
[1-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
62
Blastp_CBE
80.83
100%
-171
- C1 -
-
3TKM
2
PPARD_HUMAN
A:
[5-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
13
PsiBlast_PDB
80.65
100%
-158
- C1 -
-
5U3S
7
PPARD_HUMAN
A:
[1-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
65
Blastp_CBE
80.11
100%
-167
- C1 -
-
6A6P
4
PPARD_HUMAN
B:
[1-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
---
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
50
Blastp_CBE
80.06
100%
-157
- C1 -
-
3GWX
1
PPARD_HUMAN
B:
[1-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
17
PsiBlast_PDB
79.99
100%
-159
- C1 -
-
5U3Z
11
PPARD_HUMAN
A:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
69
Blastp_CBE
79.96
99%
-165
- C1 -
-
5U3V
8
PPARD_HUMAN
B:
[1-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
---
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
11
PsiBlast_PDB
79.82
100%
-157
- C1 -
-
5U3Q
10
PPARD_HUMAN
B:
[1-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
-
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
73
Blastp_CBE
79.80
100%
-167
- C1 -
-
3SP9
1
PPARD_HUMAN
B:
[13-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
--
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
66
Blastp_CBE
79.66
100%
-170
- C1 -
-
6A6P
4
PPARD_HUMAN
A:
[1-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
----
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
16
PsiBlast_PDB
79.61
100%
-170
- C1 -
-
5U3Y
8
PPARD_HUMAN
A:
[2-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
63
Blastp_CBE
79.19
99%
-170
- C1 -
-
2B50
3
PPARD_HUMAN
B:
[1-271]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
---
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
-----
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
4
PsiBlast_PDB
79.03
99%
-166
- C1 -
-
3ET2
4
PPARD_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
---
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
21
Blastp_CBE
78.91
99%
-166
- C1 -
-
3ET2
3
PPARD_HUMAN
B:
[19-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
--
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
46
Blastp_CBE
78.84
100%
-165
- C1 -
-
5U3Q
11
PPARD_HUMAN
A:
[4-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
----
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
36
Blastp_CBE
78.68
100%
-158
- C1 -
-
5U43
7
PPARD_HUMAN
A:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
31
Blastp_CBE
78.27
100%
-160
- C1 -
-
5U45
8
PPARD_HUMAN
B:
[4-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
--
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
71
Blastp_CBE
77.85
99%
-161
- C1 -
-
5U3T
13
PPARD_HUMAN
B:
[4-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
---
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
44
Blastp_CBE
77.83
100%
-166
- C1 -
-
5U3S
7
PPARD_HUMAN
B:
[4-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
29
Blastp_CBE
77.83
100%
-165
- C1 -
-
5U46
4
PPARD_HUMAN
B:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
68
Blastp_CBE
77.64
99%
-159
- C1 -
-
5U3W
7
PPARD_HUMAN
A:
[1-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
64
Blastp_CBE
77.58
99%
-171
- C1 -
-
2B50
3
PPARD_HUMAN
A:
[7-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
-----
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
15
PsiBlast_PDB
77.56
100%
-165
- C1 -
-
5U3X
6
PPARD_HUMAN
A:
[4-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
58
Blastp_CBE
77.53
100%
-166
- C1 -
-
5Y7X
3
PPARD_HUMAN
B:
[24-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
--
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
9
PsiBlast_PDB
77.42
100%
-165
- C1 -
-
2ZNQ
3
PPARD_HUMAN
A:
[9-276]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
30
Blastp_CBE
77.07
100%
-164
- C1 -
-
5U46
6
PPARD_HUMAN
A:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
53
Blastp_CBE
76.99
100%
-179
- C1 -
-
3DY6
1
PPARD_HUMAN
A:
[2-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
37
Blastp_CBE
76.80
100%
-162
- C1 -
-
5U42
8
PPARD_HUMAN
B:
[4-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
6
PsiBlast_PDB
76.79
100%
-165
- C1 -
-
2XYW
2
PPARD_HUMAN
A:
[21-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
35
Blastp_CBE
76.78
100%
-163
- C1 -
-
5U43
7
PPARD_HUMAN
B:
[5-271]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
24
Blastp_CBE
76.56
100%
-158
- C1 -
-
2XYX
2
PPARD_HUMAN
B:
[21-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
10
PsiBlast_PDB
76.56
100%
-168
- C1 -
-
1Y0S
2
PPARD_HUMAN
A:
[1-270]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
33
Blastp_CBE
76.46
100%
-163
- C1 -
-
5U44
4
PPARD_HUMAN
B:
[3-269]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
-------
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
28
Blastp_CBE
76.28
100%
-165
- C1 -
-
2ZNP
3
PPARD_HUMAN
B:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
---
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
67
Blastp_CBE
76.03
99%
-167
- C1 -
-
5U3W
4
PPARD_HUMAN
B:
[5-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
5
PsiBlast_PDB
76.03
100%
-153
- C1 -
-
2XYJ
4
PPARD_HUMAN
A:
[20-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
--
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
---
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
25
Blastp_CBE
75.91
100%
-163
- C1 -
-
2XYW
2
PPARD_HUMAN
B:
[21-287]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
59
Blastp_CBE
75.90
100%
-169
- C1 -
-
5Y7X
4
PPARD_HUMAN
A:
[24-290]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
---
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
26
Blastp_CBE
75.85
100%
-166
- C1 -
-
2XYJ
4
PPARD_HUMAN
B:
[20-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
----
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
7
PsiBlast_PDB
75.81
100%
-164
- C1 -
-
2XYX
2
PPARD_HUMAN
A:
[23-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
27
Blastp_CBE
75.79
100%
-165
- C1 -
-
2ZNQ
3
PPARD_HUMAN
B:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
52
Blastp_CBE
75.58
100%
-178
- C1 -
-
3DY6
1
PPARD_HUMAN
B:
[4-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
34
Blastp_CBE
75.40
100%
-169
- C1 -
-
5U44
5
PPARD_HUMAN
A:
[5-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
--------
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
39
Blastp_CBE
75.24
100%
-163
- C1 -
-
5U40
7
PPARD_HUMAN
B:
[5-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
8
PsiBlast_PDB
75.24
100%
-169
- C1 -
-
2ZNP
3
PPARD_HUMAN
A:
[10-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
-------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
61
Blastp_CBE
75.21
100%
-173
- C1 -
-
5XMX
1
PPARD_HUMAN
A:
[6-272]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
32
Blastp_CBE
75.21
100%
-161
- C1 -
-
5U45
6
PPARD_HUMAN
A:
[5-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
70
Blastp_CBE
75.11
99%
-160
- C1 -
-
5U3V
7
PPARD_HUMAN
A:
[4-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
48
Blastp_CBE
75.11
100%
-176
- C1 -
-
3PEQ
2
PPARD_HUMAN
B:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
38
Blastp_CBE
75.09
100%
-162
- C1 -
-
5U41
5
PPARD_HUMAN
B:
[4-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
14
PsiBlast_PDB
74.89
100%
-171
- C1 -
-
5U3U
5
PPARD_HUMAN
A:
[3-270]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
--
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
45
Blastp_CBE
74.79
100%
-169
- C1 -
-
5U3R
11
PPARD_HUMAN
B:
[4-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
--
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
40
Blastp_CBE
74.76
100%
-159
- C1 -
-
5U3Z
9
PPARD_HUMAN
B:
[5-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
47
Blastp_CBE
74.43
100%
-167
- C1 -
-
1Y0S
2
PPARD_HUMAN
B:
[4-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
19
PsiBlast_PDB
74.32
100%
-161
- C1 -
-
5U41
10
PPARD_HUMAN
A:
[5-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
49
Blastp_CBE
74.26
100%
-172
- C1 -
-
3PEQ
3
PPARD_HUMAN
A:
[3-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
41
Blastp_CBE
73.97
100%
-172
- C1 -
-
5U3Y
8
PPARD_HUMAN
B:
[4-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
18
PsiBlast_PDB
73.69
100%
-172
- C1 -
-
5U40
8
PPARD_HUMAN
A:
[5-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
--
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
3
PsiBlast_PDB
73.65
99%
-171
- C1 -
-
3OZ0
1
PPARD_HUMAN
A:
[19-284]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
K
Q
L
V
N
G
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
57
Blastp_CBE
73.43
100%
-175
- C1 -
-
5ZXI
1
PPARD_HUMAN
A:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
V
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
------
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
---------
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
78
Blastp_CBE
72.78
99%
-172
- C1 -
-
3D5F
1
PPARD_HUMAN
B:
[1-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
-------
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
79
Blastp_CBE
72.60
99%
-168
- C1 -
-
3D5F
1
PPARD_HUMAN
A:
[1-266]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
------
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
77
Blastp_CBE
72.43
99%
-172
- C1 -
-
2AWH
3
PPARD_HUMAN
A:
[1-268]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
----
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
----------
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
76
Blastp_CBE
71.93
99%
-177
- C1 -
-
2AWH
3
PPARD_HUMAN
B:
[1-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----------
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
-
2
PsiBlast_PDB
71.34
99%
-168
- C1 -
-
2J14
1
PPARD_HUMAN
A:
[18-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
---
S
H
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
----------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
81
Blastp_CBE
71.13
99%
-173
- C1 -
-
2BAW
3
PPARD_HUMAN
A:
[1-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
-----
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
----------
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
--
42
Blastp_CBE
70.27
100%
-168
- C1 -
-
5U3X
8
PPARD_HUMAN
B:
[5-269]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
--------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
80
Blastp_CBE
70.01
99%
-178
- C1 -
-
2BAW
3
PPARD_HUMAN
B:
[1-267]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
-------
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
------------
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Q
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
D
M
Y
93
Blastp_CBE
68.53
70%
-169
- C1 -
-
3KDU
1
PPARA_HUMAN
B:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
-
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
---
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
23
Blastp_CBE
68.10
99%
-160
- C1 -
-
2J14
1
PPARD_HUMAN
B:
[19-282]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
-----
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
--------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
60
Blastp_CBE
67.03
100%
-172
- C1 -
-
5XMX
1
PPARD_HUMAN
B:
[10-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
------
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
-----------
L
P
P
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
----
102
Blastp_CBE
66.77
69%
-161
- C1 -
-
3SP6
1
PPARA_HUMAN
A:
[13-285]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
-
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
---
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
131
Blastp_CBE
66.70
71%
-158
- C1 -
-
6L38
3
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
133
Blastp_CBE
66.51
71%
-160
- C1 -
-
6L37
6
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
94
Blastp_CBE
66.51
70%
-171
- C1 -
-
3KDU
1
PPARA_HUMAN
A:
[7-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
------
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
146
Blastp_CBE
66.49
71%
-167
- C1 -
-
6KB2
2
PPARA_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
96
Blastp_CBE
66.47
70%
-175
- C1 -
-
3KDT
1
PPARA_HUMAN
A:
[7-276]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
------
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
134
Blastp_CBE
66.44
71%
-161
- C1 -
-
6L36
4
PPARA_HUMAN
B:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
114
Blastp_CBE
66.44
71%
-164
- C1 -
-
7BQ0
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
56
Blastp_CBE
66.37
100%
-168
- C1 -
-
5ZXI
1
PPARD_HUMAN
B:
[10-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
-------
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
-------------
Y
K
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
E
T
E
T
S
L
H
P
L
L
Q
E
I
Y
K
---
132
Blastp_CBE
66.32
71%
-163
- C1 -
-
6L37
4
PPARA_HUMAN
B:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
157
Blastp_CBE
66.25
71%
-165
- C1 -
-
2P54
1
PPARA_HUMAN
A:
[1-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
154
Blastp_CBE
66.21
70%
-159
- C1 -
-
3ET1
1
PPARA_HUMAN
B:
[22-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
158
Blastp_CBE
66.09
70%
-166
- C1 -
-
2NPA
1
PPARA_HUMAN
C:
[199-468]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
A
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
---
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
95
Blastp_CBE
66.06
70%
-166
- C1 -
-
3KDT
1
PPARA_HUMAN
B:
[6-276]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
-
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
---
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
137
Blastp_CBE
65.95
71%
-159
- C1 -
-
6KYP
5
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
129
Blastp_CBE
65.87
71%
-159
- C1 -
-
6LX4
3
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
118
Blastp_CBE
65.86
71%
-160
- C1 -
-
7BPY
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
127
Blastp_CBE
65.72
71%
-158
- C1 -
-
6LX5
4
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
126
Blastp_CBE
65.71
71%
-158
- C1 -
-
6LX5
3
PPARA_HUMAN
B:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
122
Blastp_CBE
65.63
71%
-159
- C1 -
-
6LX9
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
113
Blastp_CBE
65.57
71%
-161
- C1 -
-
7BQ0
2
PPARA_HUMAN
C:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
128
Blastp_CBE
65.54
71%
-164
- C1 -
-
6LX4
2
PPARA_HUMAN
B:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
--
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
135
Blastp_CBE
65.48
71%
-158
- C1 -
-
6L36
6
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
147
Blastp_CBE
65.11
71%
-161
- C1 -
-
6KB1
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
-
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
130
Blastp_CBE
64.99
71%
-158
- C1 -
-
6L38
2
PPARA_HUMAN
B:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
124
Blastp_CBE
64.99
71%
-164
- C1 -
-
6LX7
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
--
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
121
Blastp_CBE
64.97
71%
-162
- C1 -
-
6LXA
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
-
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
138
Blastp_CBE
64.81
71%
-164
- C1 -
-
6KBA
2
PPARA_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
--
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
139
Blastp_CBE
64.69
71%
-162
- C1 -
-
6KB9
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
--
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
141
Blastp_CBE
64.67
71%
-168
- C1 -
-
6KB7
2
PPARA_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
---
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
117
Blastp_CBE
64.41
71%
-158
- C1 -
-
7BPY
2
PPARA_HUMAN
C:
[8-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
136
Blastp_CBE
64.28
71%
-155
- C1 -
-
6KYP
4
PPARA_HUMAN
B:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
144
Blastp_CBE
64.12
71%
-160
- C1 -
-
6KB4
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
--
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
142
Blastp_CBE
64.04
71%
-160
- C1 -
-
6KB6
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
--
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
143
Blastp_CBE
63.53
71%
-159
- C1 -
-
6KB5
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
----
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
89
Blastp_CBE
63.49
70%
-165
- C1 -
-
4BCR
3
PPARA_HUMAN
B:
[3-273]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
S
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
159
Blastp_CBE
63.46
70%
-151
- C1 -
-
2NPA
1
PPARA_HUMAN
A:
[199-467]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
A
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
97
Blastp_CBE
63.30
70%
-176
- C1 -
-
2REW
2
PPARA_HUMAN
A:
[8-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
-----
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
---------
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
148
Blastp_CBE
63.18
71%
-159
- C1 -
-
6KB0
2
PPARA_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
---
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
151
Blastp_CBE
62.90
71%
-160
- C1 -
-
6KAX
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
----
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
123
Blastp_CBE
62.87
71%
-161
- C1 -
-
6LX8
2
PPARA_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
---
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
155
Blastp_CBE
62.86
70%
-159
- C1 -
-
3ET1
1
PPARA_HUMAN
A:
[22-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
-------
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
112
Blastp_CBE
62.85
71%
-163
- C1 -
-
7BQ1
2
PPARA_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
---
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
---
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
149
Blastp_CBE
62.83
71%
-165
- C1 -
-
6KAZ
2
PPARA_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
-----
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
87
Blastp_CBE
62.73
70%
-167
- C1 -
-
1I7G
2
PPARA_HUMAN
A:
[18-287]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
T
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
--
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
---------
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
86
Blastp_CBE
62.60
70%
-162
- C1 -
-
6KXX
1
PPARA_HUMAN
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
125
Blastp_CBE
62.48
71%
-158
- C1 -
-
6LX6
2
PPARA_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
---
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
90
Blastp_CBE
62.41
70%
-160
- C1 -
-
4BCR
3
PPARA_HUMAN
A:
[10-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
--
140
Blastp_CBE
62.40
71%
-166
- C1 -
-
6KB8
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
----
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
92
Blastp_CBE
62.23
70%
-183
- C1 -
-
6L96
1
PPARA_HUMAN
A:
[9-274]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
------------
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
111
Blastp_CBE
62.10
71%
-164
- C1 -
-
7BQ2
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
-----
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
----
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
109
Blastp_CBE
62.01
71%
-162
- C1 -
-
7BQ4
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
-----
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
---
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
119
Blastp_CBE
61.93
71%
-168
- C1 -
-
6LXC
1
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
-----
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
--------
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
120
Blastp_CBE
61.62
71%
-171
- C1 -
-
6LXB
1
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
-----
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
---------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
247
Blastp_CBE
61.60
63%
-158
- C1 -
-
6FZG
1
PPARG_HUMAN
A:
[2-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
M
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
145
Blastp_CBE
61.59
71%
-166
- C1 -
-
6KB3
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
329
Blastp_CBE
61.53
62%
-150
- C1 -
-
6FZF
1
PPARG_HUMAN
B:
[5-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
M
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
150
Blastp_CBE
61.52
71%
-167
- C1 -
-
6KAY
2
PPARA_HUMAN
A:
[6-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
------
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
------
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
267
Blastp_CBE
61.42
63%
-155
- C1 -
-
6D8X
2
PPARG_HUMAN
A:
[23-297]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
91
Blastp_CBE
61.01
70%
-176
- C1 -
-
6L96
1
PPARA_HUMAN
B:
[10-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
------------
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
330
Blastp_CBE
60.87
62%
-152
- C1 -
-
6FZF
1
PPARG_HUMAN
A:
[9-279]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
M
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
360
Blastp_CBE
60.65
61%
-152
- C1 -
-
2ZK2
1
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
196
Blastp_CBE
60.64
61%
-159
- C1 -
-
3ADW
2
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
152
Blastp_CBE
60.55
71%
-159
- C1 -
-
3VI8
1
PPARA_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
--
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
110
Blastp_CBE
60.47
71%
-163
- C1 -
-
7BQ3
1
PPARA_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
-----
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
-------
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
22
Blastp_CBE
60.45
99%
-178
- C1 -
-
2Q5G
1
PPARD_HUMAN
B:
[15-265]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
-----
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----------
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
T
------------------
103
Blastp_CBE
60.36
70%
-170
- C1 -
-
3G8I
1
PPARA_HUMAN
A:
[4-270]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
------
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
--------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
168
Blastp_CBE
60.31
63%
-153
- C1 -
-
6FZJ
1
PPARG_HUMAN
B:
[3-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
I
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
---
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
161
Blastp_CBE
60.28
70%
-168
- C1 -
-
5AZT
1
PPARA_HUMAN
A:
[5-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
----
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
L
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
376
Blastp_CBE
60.24
62%
-155
- C1 -
-
6T1S
1
?
A:
[5-279]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
--
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
S
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
194
Blastp_CBE
60.17
61%
-153
- C1 -
-
3ADX
2
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
386
Blastp_CBE
60.16
63%
-149
- C1 -
-
5TWO
1
PPARG_HUMAN
A:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
153
Blastp_CBE
60.13
71%
-159
- C1 -
-
2ZNN
1
PPARA_HUMAN
A:
[7-273]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
--
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
346
Blastp_CBE
60.04
61%
-156
- C1 -
-
3CDP
1
PPARG_HUMAN
A:
[17-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
362
Blastp_CBE
60.00
61%
-153
- C1 -
-
2ZK1
1
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
104
Blastp_CBE
59.85
70%
-166
- C1 -
-
5HYK
1
PPARA_HUMAN
A:
[6-272]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
-----
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
353
Blastp_CBE
59.83
61%
-153
- C1 -
-
2ZK6
1
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
266
Blastp_CBE
59.69
63%
-147
- C1 -
-
6D94
1
PPARG_HUMAN
A:
[27-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
431
Blastp_CBE
59.60
63%
-155
- C1 -
-
5UGM
3
PPARG_HUMAN
B:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
177
Blastp_CBE
59.48
61%
-165
- C1 -
-
5DVC
1
PPARG_HUMAN
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
107
Blastp_CBE
59.44
71%
-162
- C1 -
-
1KKQ
1
PPARA_HUMAN
B:
[2-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
421
Blastp_CBE
59.33
61%
-154
- C1 -
-
2ZVT
1
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
S
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
363
Blastp_CBE
59.23
61%
-151
- C1 -
-
2I4Z
1
PPARG_HUMAN
A:
[17-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
207
Blastp_CBE
59.18
63%
-154
- C1 -
-
7AWD
6
PPARG_HUMAN
A:
[3-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
106
Blastp_CBE
59.12
71%
-162
- C1 -
-
1KKQ
1
PPARA_HUMAN
C:
[2-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
105
Blastp_CBE
59.04
71%
-155
- C1 -
-
1KKQ
1
PPARA_HUMAN
D:
[2-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
85
Blastp_CBE
59.01
70%
-168
- C1 -
-
6KXY
1
PPARA_HUMAN
A:
[9-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
---
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
-------
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
365
Blastp_CBE
58.97
61%
-153
- C1 -
-
2I4J
1
PPARG_HUMAN
A:
[17-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
342
Blastp_CBE
58.84
61%
-155
- C1 -
-
3HOD
1
PPARG_HUMAN
A:
[17-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
1
PsiBlast_PDB
58.83
99%
-156
- C1 -
-
2Q5G
1
PPARD_HUMAN
A:
[16-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
A
F
S
K
H
I
Y
N
A
Y
L
K
N
F
N
M
T
K
K
K
A
R
S
I
L
T
G
K
A
--
T
A
P
F
V
I
H
D
I
E
T
L
W
Q
A
E
K
G
L
V
W
-----------
E
I
S
V
H
V
F
Y
R
C
Q
C
T
T
V
E
T
V
R
E
L
T
E
F
A
K
S
I
P
S
F
S
S
L
F
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
A
I
F
A
M
L
A
S
I
V
N
K
D
G
L
L
V
A
N
G
S
G
F
V
T
R
E
F
L
R
S
L
R
K
P
F
S
D
I
I
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
L
F
I
A
A
I
I
L
C
G
D
R
P
G
L
M
N
V
P
R
V
E
A
I
Q
D
T
I
L
R
A
L
E
F
H
L
Q
A
N
H
P
D
A
Q
Y
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
M
M
Q
R
I
K
K
--------
P
L
L
Q
E
I
Y
K
---
88
Blastp_CBE
58.72
70%
-176
- C1 -
-
4CI4
1
PPARA_HUMAN
A:
[10-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
------
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
-----------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
-
449
Blastp_CBE
58.63
63%
-154
- C1 -
-
2G0G
1
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
310
Blastp_CBE
58.62
63%
-161
- C1 -
-
6IJS
1
PPARG_HUMAN
A:
[2-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
265
Blastp_CBE
58.59
63%
-154
- C1 -
-
6DBH
1
PPARG_HUMAN
A:
[25-295]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
334
Blastp_CBE
58.48
62%
-150
- C1 -
-
6T1V
1
?
A:
[12-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
Y
P
L
L
Q
E
I
Y
K
D
L
Y
108
Blastp_CBE
58.43
71%
-160
- C1 -
-
1KKQ
1
PPARA_HUMAN
A:
[2-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
N
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
V
A
K
L
V
A
N
G
I
Q
N
-
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
343
Blastp_CBE
58.32
61%
-153
- C1 -
-
3HO0
1
PPARG_HUMAN
A:
[17-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
243
Blastp_CBE
58.32
63%
-169
- C1 -
-
6DGO
1
PPARG_HUMAN
A:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
435
Blastp_CBE
58.24
63%
-151
- C1 -
-
3NOA
1
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
364
Blastp_CBE
58.24
61%
-150
- C1 -
-
2I4P
1
PPARG_HUMAN
A:
[17-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
191
Blastp_CBE
58.24
61%
-158
- C1 -
-
4A4V
1
PPARG_HUMAN
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
169
Blastp_CBE
58.22
63%
-151
- C1 -
-
6FZJ
1
PPARG_HUMAN
A:
[7-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
I
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
--
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
415
Blastp_CBE
58.21
63%
-160
- C1 -
-
3V9Y
1
PPARG_HUMAN
A:
[13-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
453
Blastp_CBE
58.15
63%
-151
- C1 -
-
2ATH
1
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
432
Blastp_CBE
58.10
63%
-150
- C1 -
-
5UGM
3
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
223
Blastp_CBE
58.05
61%
-151
- C1 -
-
5GTN
1
PPARG_HUMAN
A:
[8-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
-----
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
447
Blastp_CBE
58.03
63%
-151
- C1 -
-
2G0H
1
PPARG_HUMAN
B:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
345
Blastp_CBE
58.00
61%
-155
- C1 -
-
3CDS
1
PPARG_HUMAN
A:
[17-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
222
Blastp_CBE
57.99
61%
-155
- C1 -
-
5GTO
3
PPARG_HUMAN
A:
[13-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
419
Blastp_CBE
57.81
63%
-161
- C1 -
-
3B1M
1
PPARG_HUMAN
A:
[12-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
372
Blastp_CBE
57.81
62%
-159
- C1 -
-
3B0R
1
PPARG_HUMAN
A:
[1-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
359
Blastp_CBE
57.76
61%
-144
- C1 -
-
2ZK3
1
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
160
Blastp_CBE
57.75
70%
-164
- C1 -
-
5AZT
1
PPARA_HUMAN
B:
[5-267]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
G
K
A
S
-
N
P
P
F
V
I
H
D
M
E
T
L
C
M
A
E
K
T
L
------------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
L
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
--
347
Blastp_CBE
57.74
61%
-151
- C1 -
-
3B3K
1
PPARG_HUMAN
A:
[17-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
338
Blastp_CBE
57.73
61%
-157
- C1 -
-
3VSP
1
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
403
Blastp_CBE
57.71
63%
-143
- C1 -
-
2HFP
2
PPARG_HUMAN
A:
[11-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
366
Blastp_CBE
57.67
61%
-166
- C1 -
-
3OSW
2
PPARG_HUMAN
A:
[14-285]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
171
Blastp_CBE
57.43
61%
-160
- C1 -
-
6L89
1
PPARG_HUMAN
A:
[15-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
341
Blastp_CBE
57.42
61%
-159
- C1 -
-
3VJH
1
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
203
Blastp_CBE
57.33
61%
-159
- C1 -
-
3ADS
2
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
166
Blastp_CBE
57.27
63%
-157
- C1 -
-
1ZEO
1
PPARG_HUMAN
A:
[7-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
--------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
257
Blastp_CBE
57.23
63%
-164
- C1 -
-
1I7I
1
PPARG_HUMAN
A:
[22-291]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
318
Blastp_CBE
57.21
63%
-157
- C1 -
-
4XUM
2
PPARG_HUMAN
A:
[8-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
339
Blastp_CBE
57.17
61%
-158
- C1 -
-
3VSO
1
PPARG_HUMAN
A:
[15-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
388
Blastp_CBE
57.16
63%
-156
- C1 -
-
4CI5
1
PPARG_HUMAN
A:
[1-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
414
Blastp_CBE
57.13
63%
-159
- C1 -
-
4F9M
1
PPARG_HUMAN
A:
[13-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
320
Blastp_CBE
57.13
63%
-153
- C1 -
-
4XUH
2
PPARG_HUMAN
A:
[8-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
-------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
448
Blastp_CBE
57.05
63%
-147
- C1 -
-
2G0H
1
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
417
Blastp_CBE
56.99
63%
-163
- C1 -
-
3V9T
1
PPARG_HUMAN
A:
[12-282]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
349
Blastp_CBE
56.93
61%
-155
- C1 -
-
3AN3
1
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
416
Blastp_CBE
56.79
63%
-163
- C1 -
-
3V9V
1
PPARG_HUMAN
A:
[13-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
444
Blastp_CBE
56.72
63%
-166
- C1 -
-
2HWR
1
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
221
Blastp_CBE
56.73
61%
-157
- C1 -
-
5GTP
2
PPARG_HUMAN
A:
[13-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
189
Blastp_CBE
56.73
61%
-157
- C1 -
-
4A4W
1
PPARG_HUMAN
A:
[13-287]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
337
Blastp_CBE
56.72
61%
-154
- C1 -
-
3WMH
1
PPARG_HUMAN
A:
[15-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
390
Blastp_CBE
56.69
63%
-158
- C1 -
-
3KMG
1
PPARG_HUMAN
A:
[4-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
--------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
167
Blastp_CBE
56.67
61%
-157
- C1 -
-
6KTN
1
PPARG_HUMAN
A:
[12-283]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
A
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
187
Blastp_CBE
56.59
61%
-148
- C1 -
-
4E4K
2
PPARG_HUMAN
A:
[17-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
369
Blastp_CBE
56.57
62%
-152
- C1 -
-
6C1I
2
PPARG_HUMAN
A:
[6-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
-------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
180
Blastp_CBE
56.57
61%
-159
- C1 -
-
5DV3
1
PPARG_HUMAN
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
348
Blastp_CBE
56.56
61%
-158
- C1 -
-
3AN4
1
PPARG_HUMAN
A:
[15-286]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
452
Blastp_CBE
56.55
63%
-142
- C1 -
-
2ATH
1
PPARG_HUMAN
B:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
280
Blastp_CBE
56.54
63%
-159
- C1 -
-
5AZV
1
PPARG_HUMAN
A:
[6-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
293
Blastp_CBE
56.52
63%
-162
- C1 -
-
2VST
1
PPARG_HUMAN
A:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
250
Blastp_CBE
56.49
63%
-155
- C1 -
-
6DGL
1
PPARG_HUMAN
A:
[6-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
156
Blastp_CBE
56.49
71%
-172
- C1 -
-
3FEI
1
PPARA_HUMAN
A:
[1-267]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
K
S
L
A
K
R
I
Y
E
A
Y
L
K
N
F
N
M
N
K
V
K
A
R
V
I
L
S
-------
P
F
V
I
H
D
M
E
T
L
C
M
A
E
---------------
K
E
A
E
V
R
I
F
H
C
C
Q
C
T
S
V
E
T
V
T
E
L
T
E
F
A
K
A
I
P
G
F
A
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
Y
E
A
I
F
A
M
L
S
S
V
M
N
K
D
G
M
L
V
A
Y
G
N
G
F
I
T
R
E
F
L
K
S
L
R
K
P
F
C
D
I
M
E
P
K
F
D
F
A
M
K
F
N
A
L
E
L
D
D
S
D
I
S
L
F
V
A
A
I
I
C
C
G
D
R
P
G
L
L
N
V
G
H
I
E
K
M
Q
E
G
I
V
H
V
L
R
L
H
L
Q
S
N
H
P
D
D
I
F
L
F
P
K
L
L
Q
K
M
A
D
L
R
Q
L
V
T
E
H
A
Q
L
V
Q
I
I
K
K
T
E
S
D
A
A
L
H
P
L
L
Q
E
I
Y
R
D
M
Y
298
Blastp_CBE
56.41
63%
-157
- C1 -
-
5TTO
1
PPARG_HUMAN
A:
[2-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
200
Blastp_CBE
56.41
61%
-164
- C1 -
-
3ADU
2
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
242
Blastp_CBE
56.37
63%
-162
- C1 -
-
6FZP
1
PPARG_HUMAN
A:
[5-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
--
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
439
Blastp_CBE
56.32
63%
-164
- C1 -
-
3G9E
1
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
206
Blastp_CBE
56.24
61%
-157
- C1 -
-
3VN2
1
PPARG_HUMAN
A:
[15-285]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
----------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
252
Blastp_CBE
56.23
63%
-162
- C1 -
-
6AVI
2
PPARG_HUMAN
A:
[6-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
295
Blastp_CBE
56.21
63%
-159
- C1 -
-
2VSR
2
PPARG_HUMAN
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
446
Blastp_CBE
56.11
63%
-160
- C1 -
-
2GTK
1
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
296
Blastp_CBE
56.10
63%
-161
- C1 -
-
5U5L
1
PPARG_HUMAN
A:
[1-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
324
Blastp_CBE
55.95
63%
-156
- C1 -
-
3SZ1
2
PPARG_HUMAN
A:
[8-277]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
198
Blastp_CBE
55.92
61%
-157
- C1 -
-
3ADV
2
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
407
Blastp_CBE
55.91
62%
-157
- C1 -
-
5Y2O
1
PPARG_HUMAN
A:
[24-294]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
---------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
269
Blastp_CBE
55.87
63%
-155
- C1 -
-
3BC5
1
PPARG_HUMAN
A:
[22-296]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
---
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
--
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
201
Blastp_CBE
55.81
61%
-161
- C1 -
-
3ADT
2
PPARG_HUMAN
A:
[13-286]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
179
Blastp_CBE
55.75
61%
-155
- C1 -
-
5DV6
1
PPARG_HUMAN
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
465
Blastp_CBE
55.71
63%
-159
- C1 -
-
3ET3
1
PPARG_HUMAN
A:
[24-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
383
Blastp_CBE
55.68
62%
-147
- C1 -
-
6MS7
2
PPARG_HUMAN
A:
[2-272]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-------
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
275
Blastp_CBE
55.68
63%
-160
- C1 -
-
6JEY
2
PPARG_HUMAN
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
291
Blastp_CBE
55.61
63%
-156
- C1 -
-
2VV0
1
PPARG_HUMAN
A:
[4-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
316
Blastp_CBE
55.59
63%
-157
- C1 -
-
7LOT
1
?
A:
[8-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
210
Blastp_CBE
55.57
63%
-160
- C1 -
-
6TSG
1
PPARG_HUMAN
A:
[3-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
440
Blastp_CBE
55.54
63%
-161
- C1 -
-
3FEJ
1
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
260
Blastp_CBE
55.51
61%
-159
- C1 -
-
6F2L
1
PPARG_HUMAN
A:
[34-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
396
Blastp_CBE
55.45
63%
-161
- C1 -
-
2POB
1
PPARG_HUMAN
A:
[2-270]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
261
Blastp_CBE
55.41
61%
-163
- C1 -
-
5LSG
1
PPARG_HUMAN
A:
[34-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
241
Blastp_CBE
55.37
63%
-161
- C1 -
-
6MCZ
1
PPARG_HUMAN
A:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
445
Blastp_CBE
55.34
63%
-156
- C1 -
-
2HWQ
1
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
286
Blastp_CBE
55.30
63%
-157
- C1 -
-
2VV3
1
PPARG_HUMAN
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
254
Blastp_CBE
55.28
63%
-160
- C1 -
-
6AUG
2
PPARG_HUMAN
A:
[6-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
190
Blastp_CBE
55.28
61%
-157
- C1 -
-
4A4V
1
PPARG_HUMAN
B:
[16-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
289
Blastp_CBE
55.12
63%
-157
- C1 -
-
2VV1
1
PPARG_HUMAN
A:
[5-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
273
Blastp_CBE
55.08
63%
-158
- C1 -
-
6JF0
1
PPARG_HUMAN
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
394
Blastp_CBE
55.09
63%
-161
- C1 -
-
3FUR
1
PPARG_HUMAN
A:
[1-272]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
251
Blastp_CBE
55.08
63%
-162
- C1 -
-
6AVI
3
PPARG_HUMAN
B:
[6-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
-
476
Blastp_CBE
55.02
63%
-149
- C1 -
-
4FGY
1
PPARG_HUMAN
A:
[3-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-----
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
479
Blastp_CBE
54.99
63%
-156
- C1 -
-
6D3E
1
PPARG_HUMAN
A:
[13-280]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
----------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
456
Blastp_CBE
54.97
63%
-152
- C1 -
-
4EM9
4
PPARG_HUMAN
A:
[7-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
245
Blastp_CBE
54.88
63%
-154
- C1 -
-
4R2U
1
PPARG_HUMAN
A:
[3-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
284
Blastp_CBE
54.78
63%
-162
- C1 -
-
3X1H
1
PPARG_HUMAN
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
424
Blastp_CBE
54.75
63%
-150
- C1 -
-
3CWD
1
PPARG_HUMAN
B:
[2-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
---------
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
450
Blastp_CBE
54.72
63%
-158
- C1 -
-
2FVJ
2
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
319
Blastp_CBE
54.71
63%
-159
- C1 -
-
4XUH
2
PPARG_HUMAN
B:
[8-278]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
Y
181
Blastp_CBE
54.62
61%
-159
- C1 -
-
5DSH
1
PPARG_HUMAN
A:
[16-287]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
235
Blastp_CBE
54.55
63%
-162
- C1 -
-
6MD2
2
PPARG_HUMAN
A:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
477
Blastp_CBE
54.54
63%
-154
- C1 -
-
4Y29
1
PPARG_HUMAN
A:
[2-269]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
239
Blastp_CBE
54.53
63%
-161
- C1 -
-
6MD0
1
PPARG_HUMAN
A:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
246
Blastp_CBE
54.51
62%
-154
- C1 -
-
1NYX
1
PPARG_HUMAN
A:
[1-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
---------------
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
429
Blastp_CBE
54.45
63%
-166
- C1 -
-
6DHA
3
PPARG_HUMAN
A:
[3-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
389
Blastp_CBE
54.43
63%
-155
- C1 -
-
3KMG
1
PPARG_HUMAN
D:
[3-271]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
304
Blastp_CBE
54.42
63%
-157
- C1 -
-
2Q61
1
PPARG_HUMAN
A:
[6-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
211
Blastp_CBE
54.37
63%
-156
- C1 -
-
6T6B
1
PPARG_HUMAN
A:
[3-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
263
Blastp_CBE
54.33
63%
-153
- C1 -
-
6DGR
1
PPARG_HUMAN
A:
[27-296]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
---------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
188
Blastp_CBE
54.32
61%
-158
- C1 -
-
4A4W
1
PPARG_HUMAN
B:
[16-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
461
Blastp_CBE
54.27
63%
-158
- C1 -
-
3WJ5
1
PPARG_HUMAN
A:
[8-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
308
Blastp_CBE
54.25
63%
-157
- C1 -
-
2Q5P
1
PPARG_HUMAN
A:
[4-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
209
Blastp_CBE
54.22
63%
-158
- C1 -
-
6Y3U
1
PPARG_HUMAN
A:
[3-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
433
Blastp_CBE
54.02
63%
-142
- C1 -
-
3QT0
1
PPARG_HUMAN
A:
[3-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
204
Blastp_CBE
53.94
61%
-153
- C1 -
-
2YFE
1
PPARG_HUMAN
B:
[16-284]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
----
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
-
L
H
P
L
L
Q
E
I
Y
K
---
457
Blastp_CBE
53.93
63%
-167
- C1 -
-
4HEE
1
PPARG_HUMAN
X:
[14-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
234
Blastp_CBE
53.90
63%
-164
- C1 -
-
6MD2
2
PPARG_HUMAN
B:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
463
Blastp_CBE
53.89
63%
-158
* C1 *
-
3WJ4
1
PPARG_HUMAN
A:
[8-273]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
278
Blastp_CBE
53.82
63%
-155
- C1 -
-
5WQX
1
PPARG_HUMAN
A:
[6-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
226
Blastp_CBE
53.82
63%
-161
- C1 -
-
6VZL
1
?
A:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
--
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
430
Blastp_CBE
53.79
63%
-156
- C1 -
-
6DH9
2
PPARG_HUMAN
A:
[3-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
402
Blastp_CBE
53.77
63%
-165
- C1 -
-
3S9S
1
PPARG_HUMAN
A:
[15-283]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
385
Blastp_CBE
53.73
63%
-160
- C1 -
-
6ICJ
2
PPARG_HUMAN
A:
[1-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
---------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
391
Blastp_CBE
53.69
63%
-150
- C1 -
-
3K8S
2
PPARG_HUMAN
B:
[2-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
253
Blastp_CBE
53.66
63%
-156
- C1 -
-
6AUG
1
PPARG_HUMAN
B:
[6-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
-
425
Blastp_CBE
53.40
63%
-152
- C1 -
-
3CWD
1
PPARG_HUMAN
A:
[2-270]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
-------------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
236
Blastp_CBE
53.38
63%
-158
- C1 -
-
6MD1
2
PPARG_HUMAN
B:
[5-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
--
358
Blastp_CBE
53.20
61%
-154
- C1 -
-
2ZK3
1
PPARG_HUMAN
B:
[17-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
299
Blastp_CBE
53.19
63%
-160
- C1 -
-
4R06
1
PPARG_HUMAN
A:
[2-271]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
--
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
224
Blastp_CBE
52.89
61%
-159
- C1 -
-
6ENQ
1
PPARG_HUMAN
A:
[9-280]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
441
Blastp_CBE
52.83
63%
-160
- C1 -
-
2Q8S
1
PPARG_HUMAN
A:
[3-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
301
Blastp_CBE
52.68
63%
-153
- C1 -
-
2Q6R
1
PPARG_HUMAN
B:
[4-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
-----
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
255
Blastp_CBE
52.63
61%
-157
- C1 -
-
6ZLY
1
PPARG_HUMAN
A:
[30-297]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
240
Blastp_CBE
52.60
63%
-161
- C1 -
-
6MCZ
1
PPARG_HUMAN
B:
[5-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
174
Blastp_CBE
52.59
61%
-167
- C1 -
-
5HZC
1
PPARG_HUMAN
A:
[17-284]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
437
Blastp_CBE
52.58
63%
-154
- C1 -
-
3IA6
1
PPARG_HUMAN
A:
[3-268]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
287
Blastp_CBE
52.53
63%
-157
- C1 -
-
2VV2
2
PPARG_HUMAN
B:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
----
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
-----
P
L
L
Q
E
I
Y
K
---
258
Blastp_CBE
52.53
61%
-162
- C1 -
-
6T9C
1
PPARG_HUMAN
A:
[34-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
361
Blastp_CBE
52.42
61%
-154
- C1 -
-
2ZK1
1
PPARG_HUMAN
B:
[17-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
297
Blastp_CBE
52.38
63%
-158
- C1 -
-
5TTO
1
PPARG_HUMAN
B:
[3-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
-------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
--
248
Blastp_CBE
52.30
63%
-161
- C1 -
-
6DGQ
1
PPARG_HUMAN
A:
[6-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
-
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
259
Blastp_CBE
52.18
61%
-161
- C1 -
-
6QJ5
1
PPARG_HUMAN
A:
[34-301]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
---
311
Blastp_CBE
52.14
63%
-160
- C1 -
-
3R5N
2
PPARG_HUMAN
A:
[4-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
--
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
---------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
----
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
290
Blastp_CBE
52.02
63%
-165
- C1 -
-
2VV0
1
PPARG_HUMAN
B:
[7-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
-----------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
-
462
Blastp_CBE
52.01
63%
-161
- C1 -
-
3WJ4
1
PPARG_HUMAN
B:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
---
H
P
L
L
Q
E
I
Y
K
D
--
172
Blastp_CBE
51.93
61%
-153
- C1 -
-
6AD9
1
PPARG_HUMAN
A:
[18-286]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
-
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
244
Blastp_CBE
51.65
63%
-158
- C1 -
-
4R2U
1
PPARG_HUMAN
D:
[6-273]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
--
309
Blastp_CBE
51.60
63%
-160
- C1 -
-
2Q59
1
PPARG_HUMAN
B:
[4-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
---------
H
P
L
L
Q
E
I
Y
K
D
--
384
Blastp_CBE
51.59
63%
-176
- C1 -
-
6ILQ
1
PPARG_HUMAN
A:
[2-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
--
S
P
F
V
I
Y
D
M
N
S
L
M
M
-------------------
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
356
Blastp_CBE
51.34
61%
-146
- C1 -
-
2ZK4
1
PPARG_HUMAN
B:
[17-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
256
Blastp_CBE
51.09
63%
-154
- C1 -
-
1I7I
1
PPARG_HUMAN
B:
[22-288]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
----
227
Blastp_CBE
51.02
63%
-159
- C1 -
-
6PDZ
1
PPARG_HUMAN
B:
[1-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
-------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
382
Blastp_CBE
50.99
62%
-162
- C1 -
-
7JQG
1
?
A:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
---
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
---------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
E
K
---
225
Blastp_CBE
50.65
63%
-164
- C1 -
-
6VZL
1
?
B:
[5-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
-----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
L
-
315
Blastp_CBE
50.45
63%
-153
- C1 -
-
7LOT
1
?
B:
[8-276]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
-------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
K
D
--
230
Blastp_CBE
50.41
63%
-161
- C1 -
-
6ONI
1
PPARG_HUMAN
B:
[1-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
460
Blastp_CBE
50.24
63%
-156
- C1 -
-
3WJ5
1
PPARG_HUMAN
B:
[8-274]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
--------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
--
459
Blastp_CBE
50.23
63%
-155
- C1 -
-
3R8A
1
PPARG_HUMAN
A:
[14-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-----------
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
-------
199
Blastp_CBE
49.68
61%
-150
- C1 -
-
3ADU
3
PPARG_HUMAN
B:
[17-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
--
S
L
H
P
L
L
Q
E
I
Y
----
371
Blastp_CBE
49.24
62%
-168
- C1 -
-
3B0R
1
PPARG_HUMAN
B:
[5-271]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
---
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
-------
H
P
L
L
Q
E
I
Y
----
469
Blastp_CBE
49.03
62%
-152
- C1 -
-
4L98
2
PPARG_HUMAN
B:
[7-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
213
Blastp_CBE
48.65
61%
-162
- C1 -
-
3PO9
5
PPARG_HUMAN
B:
[16-286]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
-----
H
P
L
L
Q
E
I
Y
K
D
L
Y
464
Blastp_CBE
48.49
63%
-159
- C1 -
-
6TDC
2
PPARG_HUMAN
A:
[24-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
279
Blastp_CBE
48.36
63%
-164
- C1 -
-
5AZV
1
PPARG_HUMAN
B:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
-------
P
L
L
Q
E
I
Y
K
---
471
Blastp_CBE
47.90
62%
-148
- C1 -
-
4L96
1
PPARG_HUMAN
A:
[7-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
-----------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
228
Blastp_CBE
47.87
63%
-160
- C1 -
-
6PDZ
1
PPARG_HUMAN
A:
[5-275]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
----------
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
-----
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
292
Blastp_CBE
47.86
63%
-167
- C1 -
-
2VST
1
PPARG_HUMAN
B:
[6-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
----
K
H
I
T
------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
------
H
P
L
L
Q
E
I
Y
K
---
193
Blastp_CBE
47.79
61%
-156
- C1 -
-
3ADX
1
PPARG_HUMAN
B:
[17-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
---
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
---------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
----
H
P
L
L
Q
E
I
Y
----
165
Blastp_CBE
47.20
63%
-158
- C1 -
-
2P4Y
2
PPARG_HUMAN
A:
[5-277]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
-----
K
S
P
F
V
I
Y
D
M
N
S
------------------------
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
270
Blastp_CBE
45.88
63%
-164
- C1 -
-
6DCU
1
PPARG_HUMAN
B:
[26-289]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
-------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
--------
173
Blastp_CBE
45.64
61%
-161
- C1 -
-
5HZC
1
PPARG_HUMAN
B:
[17-283]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
----------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
-
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
----
455
Blastp_CBE
45.39
63%
-173
- C1 -
-
4EM9
4
PPARG_HUMAN
B:
[7-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
-----
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
---
F
K
H
I
--------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
---------
L
H
P
L
L
Q
E
I
Y
K
---
307
Blastp_CBE
44.45
63%
-164
- C1 -
-
2Q5P
1
PPARG_HUMAN
B:
[4-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
----
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
----
F
K
H
I
T
--------
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
--------
L
H
P
L
L
Q
E
I
Y
K
D
--
370
Blastp_CBE
44.33
62%
-172
- C1 -
-
2VV1
1
PPARG_HUMAN
B:
[8-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
--
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
-----------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
-------
P
L
L
Q
E
I
Y
----
470
Blastp_CBE
40.25
62%
-149
- C1 -
-
4L98
2
PPARG_HUMAN
A:
[7-275]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
--------------------------
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
L
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
164
Blastp_CBE
37.66
63%
-171
- C1 -
-
2P4Y
1
PPARG_HUMAN
B:
[9-277]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
-------
S
P
F
V
I
Y
D
M
N
S
-----------------------
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
------------
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
302
Blastp_CBE
35.99
63%
-157
- C1 -
-
2Q6R
1
PPARG_HUMAN
A:
[4-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
Q
G
C
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
----
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
-----------------
H
P
L
L
Q
E
I
Y
K
D
L
-
422
Blastp_CBE
28.90
61%
-69
- C1 -
-
6K0T
1
PPARG_HUMAN
C:
[15-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
-----
K
E
V
A
I
R
I
F
-
Q
G
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
423
Blastp_CBE
27.20
61%
-74
- C1 -
-
6K0T
1
PPARG_HUMAN
A:
[15-287]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
P
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
-
Q
G
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
483
Blastp_CBE
24.85
62%
-73
- C1 -
-
3ET0
1
PPARG_HUMAN
A:
[24-292]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
------------
K
E
V
A
I
R
I
F
-
Q
G
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
481
Blastp_CBE
23.64
62%
-72
- C1 -
-
6C5T
1
PPARG_HUMAN
A:
[8-276]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
-----
Q
S
K
E
V
A
I
R
I
F
-
Q
G
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
-
L
H
P
L
L
Q
E
I
Y
K
D
L
Y
466
Blastp_CBE
22.95
62%
-69
- C1 -
-
2Q59
1
PPARG_HUMAN
A:
[4-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
S
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
--------------
K
E
V
A
I
R
I
F
-
Q
G
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
-
480
Blastp_CBE
22.16
62%
-64
- C1 -
-
6C5Q
2
PPARG_HUMAN
A:
[13-281]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
D
L
R
A
L
A
K
H
L
Y
D
S
Y
I
K
S
F
P
L
T
K
A
K
A
R
A
I
L
T
G
K
T
T
D
K
S
P
F
V
I
Y
D
M
N
S
L
M
M
G
E
D
K
I
K
F
K
H
I
T
P
L
Q
E
Q
S
K
E
V
A
I
R
I
F
-
Q
G
Q
F
R
S
V
E
A
V
Q
E
I
T
E
Y
A
K
S
I
P
G
F
V
N
L
D
L
N
D
Q
V
T
L
L
K
Y
G
V
H
E
I
I
Y
T
M
L
A
S
L
M
N
K
D
G
V
L
I
S
E
G
Q
G
F
M
T
R
E
F
L
K
S
L
R
K
P
F
G
D
F
M
E
P
K
F
E
F
A
V
K
F
N
A
L
E
L
D
D
S
D
L
A
I
F
I
A
V
I
I
L
S
G
D
R
P
G
L
L
N
V
K
P
I
E
D
I
Q
D
N
L
L
Q
A
L
E
L
Q
L
K
L
N
H
P
E
S
S
Q
L
F
A
K
L
L
Q
K
M
T
D
L
R
Q
I
V
T
E
H
V
Q
L
L
Q
V
I
K
K
T
E
T
D
M
S
L
H
P
L
L
Q
E
I
Y
K
D
L
Y