@TOME V3
(Feb 2022)
Ref.
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
3D Alignment Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
3D Alignment Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
PDB Ligands
Affinity Score
Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
Sequence Alignment
Tab of Complexes
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : H_NR3C2_MCR: (2021-05-27 )
METKGYHSLPEGLDMERRWGQVSQAVERSSLGPTERTDENNYMEIVNVSCVSGAIPNNSTQGSSKEKQELLPCLQQDNNRPGILTSDIKTELESKELSATVAESMGLYMDSVRDADYSYEQQNQQGSMSPAKIYQNVEQLVKFYKGNGHRPSTLSCVNTPLRSFMSDSGSSVNGGVMRAIVKSPIMCHEKSPSVCSPLNMTSSVCSPAGINSVSSTTASFGSFPVHSPITQGTPLTCSPNAENRGSRSHSPAHASNVGSPLSSPLSSMKSSISSPPSHCSVKSPVSSPNNVTLRSSVSSPANINNSRCSVSSPSNTNNRSTLSSPAASTVGSICSPVNNAFSYTASGTSAGSSTLRDVVPSPDTQEKGAQEVPFPKTEEVESAISNGVTGQLNIVQYIKPEPDGAFSSSCLGGNSKINSDSSFSVPIKQESTKHSCSGTSFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGNCEGSGFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSARDQSFQHLSSFPPVNTLVESWKSHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGIHEEQPQQQQPPPPPPPPQSPEEGTTYIAPAKEPSVNTALVPQLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFHRK
Atome Classification :
(63 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760.......770.......780.......790.......800.......810.......820.......830.......840.......850.......860.......870.......880.......890.......900.......910.......920.......930.......940.......950.......960.......970.......980..
(Atome)
(Ident)
(Tito)
(Num)
(QMean)
(Ligand)
(Uniprot)
METKGYHSLPEGL
D
M
E
R
R
W
G
Q
V
S
Q
A
V
E
RSSLGPTERTDENN
Y
M
E
I
V
N
V
S
C
VSGAIPNNSTQGS
S
K
E
K
Q
E
L
L
P
C
L
Q
QDNNRP
G
I
L
T
S
D
I
K
T
E
L
E
S
K
E
L
S
A
T
V
A
E
S
M
G
L
Y
M
D
SVRDADYS
Y
E
Q
QNQQGSM
S
P
A
K
I
Y
Q
N
V
E
Q
L
V
K
F
Y
KGNGHRPS
T
L
S
C
V
N
T
P
L
R
S
F
M
S
DSGSSV
N
G
G
V
M
R
A
I
V
KSPIMCHEKSPSVCSPLN
M
T
S
SVCSPAGINSVSSTTASFGSFPVHSPITQGTP
L
T
CSPNAENRGSRSHSPAHASNVGS
P
L
S
S
P
L
S
S
M
K
S
S
ISSPPSHCSVKSPVSSPN
N
V
T
L
RSSVSSPANINNS
R
C
SVSSPSNTNNRSTLSSP
A
A
S
T
V
G
S
I
C
S
P
VNN
A
F
S
Y
TASGTSAG
S
S
T
L
R
DVVPSPDTQEKGAQEVPFP
K
T
E
E
V
E
S
A
I
SNGVTGQ
L
N
I
V
Q
Y
IKPEPDGAFSSSCLGGNSKINSDSSF
S
V
PIKQESTKHSCSGTSFKGNPTVNPFPFMDGSY
F
S
FMDDKDYYSLSGILGPPVPGFDGNCEGSG
F
P
VGIKQEPDDGSYYPEASIPS
S
A
I
V
G
VNSGG
Q
S
F
H
Y
R
IGA
Q
G
T
I
S
LSRSAR
D
Q
S
F
Q
H
L
SSFP
P
V
N
T
L
V
E
S
W
K
SHGDLSSRRSDGY
P
V
L
E
Y
IPENVSS
S
T
L
R
SVSTGSSRP
S
K
I
C
L
V
CGDEASG
C
H
Y
G
V
V
T
CG
S
C
K
V
F
F
K
R
A
VEGQH
N
Y
L
CAGRN
D
C
I
I
D
K
I
RRKNC
P
A
C
R
L
Q
K
C
L
Q
AGMNLG
A
R
K
S
K
KL
G
K
LKGIHEEQPQQQQPPPPPPPPQSPEEG
T
T
Y
I
APAKEPSVN
T
A
L
V
P
Q
L
S
T
I
S
RALTPS
P
V
M
V
L
ENIEP
E
I
V
Y
AGYDSSKP
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
VLPGFKNLPLED
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
SYKHTNS
Q
F
L
Y
FAPDLVF
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
TIPKDGL
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
KCPNNS
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
RES
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
QLPKVESGNAK
P
L
Y
FHRK
22
Blastp_CBE
84.29
99%
-139
- C1 -
-
2AB2
1
B:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
-
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
24
Blastp_CBE
84.26
99%
-137
- C1 -
-
2AA6
1
B:
[13-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
4
PsiBlast_PDB
83.42
99%
-136
- C1 -
-
2AA6
1
MCR_HUMAN
A:
[13-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
-
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
11
PsiBlast_PDB
82.85
98%
-139
- C1 -
-
3VHV
4
A:
[3-260]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
-----
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
K
5
PsiBlast_PDB
82.83
99%
-133
- C1 -
-
2AAX
-
MCR_HUMAN
A:
[13-274]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
-
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
3
PsiBlast_PDB
81.93
99%
-136
- C1 -
-
2AA7
3
A:
[18-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
----
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
7
PsiBlast_PDB
81.91
99%
-140
- C1 -
-
3VHU
1
A:
[38-292]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
------
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
36
Blastp_CBE
81.89
99%
-159
- C1 -
-
2OAX
1
MCR_HUMAN
B:
[11-254]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
-----------
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
6
PsiBlast_PDB
81.51
99%
-131
- C1 -
-
2AB2
1
MCR_HUMAN
A:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
-
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
1
PsiBlast_PDB
81.47
99%
-138
- C1 -
-
2AA2
4
A:
[18-274]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
-----
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
34
Blastp_CBE
80.38
99%
-159
- C1 -
-
2OAX
1
MCR_HUMAN
D:
[10-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
---
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
--------
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
21
Blastp_CBE
80.37
99%
-135
- C1 -
-
2AA5
1
B:
[14-273]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
-----
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
2
PsiBlast_PDB
80.06
99%
-129
- C1 -
-
2AA5
1
MCR_HUMAN
A:
[13-273]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
V
P
Q
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
13
PsiBlast_PDB
79.81
99%
-131
- C1 -
-
2A3I
1
A:
[1-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
32
Blastp_CBE
79.37
99%
-153
- C1 -
-
2OAX
1
F:
[10-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
---
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
----
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
8
PsiBlast_PDB
79.17
98%
-123
- C1 -
-
3WFF
1
A:
[18-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
I
S
R
A
L
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
K
12
PsiBlast_PDB
79.13
99%
-159
- C1 -
-
2ABI
1
MCR_HUMAN
A:
[9-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
-------
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
---------
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
35
Blastp_CBE
78.98
99%
-153
- C1 -
-
2OAX
1
MCR_HUMAN
C:
[10-254]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
---
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
---------
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
18
PsiBlast_PDB
78.55
99%
-147
- C1 -
-
4UDA
2
A:
[5-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
----
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
-
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
47
Blastp_CBE
77.58
99%
-141
- C1 -
-
5L7E
5
A:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
-----
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
15
PsiBlast_PDB
77.56
99%
-154
- C1 -
-
1YA3
1
MCR_HUMAN
A:
[8-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
-----
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
42
Blastp_CBE
77.32
99%
-134
- C1 -
-
4UDB
3
A:
[25-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
---
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
10
PsiBlast_PDB
77.12
98%
-125
- C1 -
-
4PF3
9
A:
[26-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
-
28
Blastp_CBE
76.96
99%
-154
- C1 -
-
1YA3
1
MCR_HUMAN
B:
[9-253]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
-------
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
9
PsiBlast_PDB
76.62
98%
-123
- C1 -
-
3WFG
14
A:
[26-274]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
C
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
V
K
P
L
Y
F
H
R
-
14
PsiBlast_PDB
76.36
99%
-149
- C1 -
-
1Y9R
1
MCR_HUMAN
A:
[8-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
26
Blastp_CBE
76.17
99%
-145
- C1 -
-
2ABI
1
MCR_HUMAN
B:
[9-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
----
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
29
Blastp_CBE
76.14
99%
-143
- C1 -
-
1Y9R
1
B:
[8-255]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
----------
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
27
Blastp_CBE
76.05
99%
-150
- C1 -
-
1YA3
1
C:
[8-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
---
V
Y
A
G
Y
D
S
---
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
46
Blastp_CBE
75.96
99%
-131
- C1 -
-
5L7G
2
A:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
-
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
20
PsiBlast_PDB
75.91
99%
-132
- C1 -
-
5MWY
1
A:
[19-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
------
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
31
Blastp_CBE
75.79
99%
-149
- C1 -
-
5HCV
1
MCR_HUMAN
B:
[11-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
----
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
---------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
25
Blastp_CBE
75.50
99%
-146
- C1 -
-
2ABI
1
C:
[9-254]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
----
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
C
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
--------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
43
Blastp_CBE
75.48
99%
-140
- C1 -
-
6GGG
1
A:
[37-271]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
Y
A
G
Y
D
--
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
-
41
Blastp_CBE
75.48
99%
-135
- C1 -
-
6GG8
2
A:
[25-272]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
45
Blastp_CBE
74.90
99%
-128
- C1 -
-
5L7H
2
A:
[19-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
-
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
17
PsiBlast_PDB
74.45
99%
-140
- C1 -
-
5HCV
1
MCR_HUMAN
A:
[11-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
----
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
-----
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
--
44
Blastp_CBE
74.41
99%
-119
- C1 -
-
6GEV
4
A:
[19-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
L
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
N
N
S
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
---
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
61
Blastp_CBE
73.61
63%
-148
- C1 -
-
6W9L
2
?
A:
[2-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
19
PsiBlast_PDB
73.60
99%
-127
- C1 -
-
5MWP
1
A:
[19-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
S
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
D
S
S
K
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
-------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
E
S
G
N
A
K
P
L
Y
F
H
R
K
49
Blastp_CBE
73.26
75%
-152
- C1 -
-
2Q1H
3
?
A:
[5-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
L
E
A
I
E
P
E
V
V
Y
A
G
Y
D
N
S
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
G
K
Q
M
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
R
Q
I
S
Q
E
F
V
R
L
Q
V
T
Y
E
E
F
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
R
R
A
I
A
---
N
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
D
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
K
-
57
Blastp_CBE
73.07
63%
-150
- C1 -
-
6W9K
2
?
A:
[2-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
65
Blastp_CBE
72.45
63%
-150
- C1 -
-
4E2J
2
?
A:
[4-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
-
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
63
Blastp_CBE
72.31
63%
-149
- C1 -
-
6NWK
6
?
A:
[2-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
66
Blastp_CBE
72.18
63%
-147
* C1 *
-
5UFS
1
?
B:
[2-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
64
Blastp_CBE
71.93
63%
-149
- C1 -
-
4E2J
3
?
B:
[4-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
30
Blastp_CBE
71.87
99%
-141
- C1 -
-
5HCV
1
C:
[11-255]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
V
M
V
L
E
N
I
E
P
E
I
V
Y
A
G
Y
----
P
D
T
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
F
N
E
E
K
M
H
Q
S
A
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
---------
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
F
R
E
S
H
A
L
K
V
E
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
---
N
A
K
P
L
Y
F
H
--
67
Blastp_CBE
71.79
63%
-146
- C1 -
-
5UFS
1
?
A:
[2-248]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
-
50
Blastp_CBE
71.68
74%
-150
- C1 -
-
2Q3Y
2
?
A:
[5-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
S
I
L
E
A
I
E
P
E
V
V
Y
A
G
Y
D
N
S
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
G
K
Q
M
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
R
Q
I
S
Q
E
F
V
R
L
Q
V
T
Y
E
E
F
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
R
R
A
I
---
E
N
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
D
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
K
-
62
Blastp_CBE
71.46
63%
-149
- C1 -
-
6NWL
6
?
A:
[2-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
52
Blastp_CBE
70.73
70%
-141
- C1 -
-
3RY9
3
?
B:
[2-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
M
I
S
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
--
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
E
S
K
T
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
-
58
Blastp_CBE
70.65
63%
-146
- C1 -
-
3GN8
1
?
B:
[2-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
60
Blastp_CBE
70.25
63%
-145
- C1 -
-
6W9M
3
?
A:
[4-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
V
-
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
53
Blastp_CBE
70.16
70%
-139
- C1 -
-
3RY9
2
?
A:
[2-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
M
I
S
I
L
E
A
I
E
P
D
V
I
Y
A
G
Y
D
S
T
L
P
D
T
T
N
R
L
L
S
S
L
N
R
L
G
G
R
Q
M
I
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
Q
H
T
N
G
N
M
L
Y
F
A
P
D
L
I
F
N
E
E
R
M
Q
Q
S
S
M
Y
E
L
C
K
G
M
H
K
I
S
L
E
F
V
R
L
Q
V
S
Y
E
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
A
F
D
E
I
R
M
S
Y
I
K
E
L
G
K
A
I
V
K
R
------
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
E
S
K
T
L
S
V
E
F
P
E
M
L
V
E
I
I
S
N
Q
L
P
K
V
M
A
G
M
A
K
P
L
L
F
H
Q
K
59
Blastp_CBE
70.11
63%
-146
- C1 -
-
3GN8
1
?
A:
[2-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
T
L
I
S
L
L
E
V
I
E
P
E
V
L
Y
S
G
Y
D
S
T
L
P
D
T
S
T
R
L
M
S
T
L
N
R
L
G
G
R
Q
V
V
S
A
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
L
Q
Y
S
W
M
S
L
M
A
F
S
L
G
W
R
S
Y
K
Q
S
N
G
N
M
L
C
F
A
P
D
L
V
I
N
E
E
R
M
Q
L
P
Y
M
Y
D
Q
C
Q
Q
M
L
K
I
S
S
E
F
V
R
L
Q
V
S
Y
D
E
Y
L
C
M
K
V
L
L
L
L
S
T
V
P
K
D
G
L
K
S
Q
A
V
F
D
E
I
R
M
T
Y
I
K
E
L
G
K
A
I
V
K
R
E
G
N
S
S
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
E
M
V
G
G
L
L
Q
F
C
F
Y
T
F
-
V
N
K
S
L
S
V
E
F
P
E
M
L
A
E
I
I
S
N
Q
L
P
K
F
K
A
G
S
V
K
P
L
L
F
H
Q
K
51
Blastp_CBE
69.80
71%
-142
- C1 -
-
4LTW
4
?
A:
[4-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
54
Blastp_CBE
68.11
71%
-136
- C1 -
-
4FNE
5
?
A:
[6-251]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
-
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
---
40
Blastp_CBE
66.82
99%
-180
- C1 -
-
6L88
1
MCR_HUMAN
A:
[30-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
Y
F
A
P
D
L
V
----------
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
N
--
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
------------
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
--
G
N
A
K
P
L
Y
F
H
R
-
56
Blastp_CBE
66.44
71%
-136
- C1 -
-
4FN9
6
?
A:
[6-253]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
K
-
55
Blastp_CBE
66.23
71%
-138
- C1 -
-
4FN9
3
?
B:
[6-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
L
I
S
I
L
Q
A
I
E
P
E
V
V
Y
A
G
Y
D
N
T
Q
P
D
T
T
N
Y
L
L
S
S
L
N
R
L
A
E
K
Q
L
V
S
V
V
K
W
A
K
A
L
P
G
F
R
N
L
H
L
D
D
Q
M
T
L
I
Q
Y
S
W
M
G
L
M
A
F
A
M
G
W
R
S
Y
K
H
T
N
G
Q
M
L
Y
F
A
P
D
L
I
F
N
E
Q
R
M
Q
Q
S
A
M
Y
D
L
C
Q
G
M
Q
Q
I
S
Q
E
F
V
R
L
Q
V
T
Q
E
E
F
L
C
M
K
A
L
L
L
L
S
T
V
P
K
E
G
L
K
S
Q
A
S
F
D
E
M
R
M
N
Y
I
K
E
L
N
R
A
I
A
K
K
E
N
N
S
A
Q
N
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
G
G
L
L
Q
F
C
F
Y
T
F
V
Q
S
Q
A
L
S
V
E
F
P
E
M
L
V
E
I
I
S
A
Q
L
P
K
V
L
A
G
M
A
K
P
L
L
F
H
--
38
Blastp_CBE
65.33
99%
-185
- C1 -
-
6L88
1
MCR_HUMAN
C:
[29-250]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
L
-----------------
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
N
--
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
-------------
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
--
G
N
A
K
P
L
Y
F
H
R
-
37
Blastp_CBE
64.97
99%
-182
- C1 -
-
6L88
1
D:
[30-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
F
------------------
M
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
N
--
G
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
F
Y
T
----------
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
--
G
N
A
K
P
L
Y
F
H
R
-
39
Blastp_CBE
60.53
99%
-177
- C1 -
-
6L88
1
MCR_HUMAN
B:
[30-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
L
L
S
T
L
N
R
L
A
G
K
Q
M
I
Q
V
V
K
W
A
K
V
L
P
G
F
K
N
L
P
L
E
D
Q
I
T
L
I
Q
Y
S
W
M
S
L
S
S
F
A
L
S
W
R
S
Y
K
H
T
N
S
Q
--------------------
Y
E
L
C
Q
G
M
H
Q
I
S
L
Q
F
V
R
L
Q
L
T
F
E
E
Y
T
I
M
K
V
L
L
L
L
S
T
I
P
K
D
G
L
K
S
Q
A
A
F
E
E
M
R
T
N
Y
I
K
E
L
R
K
M
V
T
K
S
P
N
---
Q
S
W
Q
R
F
Y
Q
L
T
K
L
L
D
S
M
H
D
L
V
S
D
L
L
E
F
C
-------------
F
P
A
M
L
V
E
I
I
S
D
Q
L
P
K
V
--
G
N
A
K
P
L
Y
F
H
R
-